Xin Duan, PhD

Title(s)Associate Professor, Ophthalmology
SchoolSchool of Medicine
Address1550 Fourth Street, #448C
San Francisco CA 94158
Phone415-476-4233
ORCID ORCID Icon0000-0001-5260-8972 Additional info
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    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAPostdoc12/2016Neuroscience
    Johns Hopkins University, Baltimore, MDPh.D.12/2008Neuroscience
    Tsinghua University, BeijingB.S.07/2002Biological Sciences
    Collapse awards and honors
    Research to Prevent Blindness2025  - 2028Stein Innovation Award
    Kavli Institute for Fundamental Neuroscience2020  - 2021Kavli Neuroscience Institute Collaborative Award
    Glaucoma Research Foundation 2019  - 2028Catalyst for a Cure Team Award (CFC3)
    The Klingenstein Foundation2018  - 2021Klingenstein-Simons Neuroscience Fellowship
    Whitehall Foundation2018  - 2021Whitehall Neuroscience Scholarship
    Research to Prevent Blindness2017  - 2020Career Development Award
    UCSF Weill Institute of Neuroscience2017  - 2018Trailblazer Award in Neuroscience
    Life Science Research Foundation2010  - 2013HHMI-LSRF Fellowship
    Johns Hopkins University School of Medicine2008Young Investigator Award
    Tsinghua University2002Graduation with Highest Honor

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    BRAIN CONNECTS: Scalable Approaches for Bidirectional Brain-wide Trans-Neuronal Connectivity Mapping of Defined Cell Types
    NIH U01NS136405Aug 15, 2024 - Jul 31, 2027
    Role: Principal Investigator
    MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORS
    NIH R01NS123912Aug 15, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal Circuits
    NIH R01EY030138Jan 1, 2020 - Dec 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular and cellular dynamics of the developing human neocortex. Nature. 2025 Jan 08. Wang L, Wang C, Moriano JA, Chen S, Zuo G, Cebrián-Silla A, Zhang S, Mukhtar T, Wang S, Song M, de Oliveira LG, Bi Q, Augustin JJ, Ge X, Paredes MF, Huang EJ, Alvarez-Buylla A, Duan X, Li J, Kriegstein AR. PMID: 39779846.
      View in: PubMed   Mentions: 7     Fields:    
    2. Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers. bioRxiv. 2024 Dec 25. Lum MR, Patel SH, Graham HK, Zhao M, Yi Y, Li L, Yao M, La Torre A, Santina LD, Han Y, Hu Y, Welsbie DS, Duan X. PMID: 39763956; PMCID: PMC11703203.
      View in: PubMed   Mentions:
    3. Molecular and spatial analysis of ganglion cells on retinal flatmounts: diversity, topography, and perivascularity. bioRxiv. 2024 Dec 17. Tsai NY, Nimkar K, Zhao M, Lum MR, Yi Y, Garrett TR, Wang Y, Toma K, Caval-Holme F, Reddy N, Ehrlich AT, Kriegstein AR, Do MTH, Sivyer B, Shekhar K, Duan X. PMID: 39763751; PMCID: PMC11702564.
      View in: PubMed   Mentions:
    4. Endogenous opioid signalling regulates spinal ependymal cell proliferation. Nature. 2024 Oct; 634(8033):407-414. Yue WWS, Touhara KK, Toma K, Duan X, Julius D. PMID: 39294372.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact. Cell. 2024 May 23; 187(11):2767-2784.e23. Toma K, Zhao M, Zhang S, Wang F, Graham HK, Zou J, Modgil S, Shang WH, Tsai NY, Cai Z, Liu L, Hong G, Kriegstein AR, Hu Y, Körbelin J, Zhang R, Liao YJ, Kim TN, Ye X, Duan X. PMID: 38733989; PMCID: PMC11223890.
      View in: PubMed   Mentions: 6     Fields:    
    6. Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions. J Neurosci. 2024 01 31; 44(5). Matcham AC, Toma K, Tsai NY, Sze CJ, Lin PY, Stewart IF, Duan X. PMID: 38123991; PMCID: PMC10860569.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy. Cell Rep. 2023 09 26; 42(9):113038. Zhao M, Toma K, Kinde B, Li L, Patel AK, Wu KY, Lum MR, Tan C, Hooper JE, Kriegstein AR, La Torre A, Liao YJ, Welsbie DS, Hu Y, Han Y, Duan X. PMID: 37624696; PMCID: PMC10591811.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    8. Postsynaptic neuronal activity promotes regeneration of retinal axons. Cell Rep. 2023 05 30; 42(5):112476. Varadarajan SG, Wang F, Dhande OS, Le P, Duan X, Huberman AD. PMID: 37141093; PMCID: PMC10247459.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Coordinated cadherin functions sculpt respiratory motor circuit connectivity. Elife. 2022 12 30; 11. Vagnozzi AN, Moore MT, Lin M, Brozost EM, Kc R, Agarwal A, Schwarz LA, Duan X, Zampieri N, Landmesser LT, Philippidou P. PMID: 36583530; PMCID: PMC9910829.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Longitudinal in vivo Ca2+ imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2206829119. Li L, Feng X, Fang F, Miller DA, Zhang S, Zhuang P, Huang H, Liu P, Liu J, Sredar N, Liu L, Sun Y, Duan X, Goldberg JL, Zhang HF, Hu Y. PMID: 36409915; PMCID: PMC9889883.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Live, die, or regenerate? New insights from multi-omic analyses. Neuron. 2022 08 17; 110(16):2516-2519. Tsai NY, Welsbie DS, Duan X. PMID: 35981522; PMCID: PMC9521179.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin. Nat Neurosci. 2022 05; 25(5):659-674. Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X. PMID: 35524141; PMCID: PMC9172271.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    13. Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener. 2022 03 21; 17(1):23. Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Bovenkamp DE, Calkins DJ. PMID: 35313950; PMCID: PMC8935795.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    14. Oestrogen engages brain MC4R signalling to drive physical activity in female mice. Nature. 2021 11; 599(7883):131-135. Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA. PMID: 34646010; PMCID: PMC9113400.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    15. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33597-33607. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207; PMCID: PMC7777023.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Molecular mechanisms regulating synaptic specificity and retinal circuit formation. Wiley Interdiscip Rev Dev Biol. 2021 01; 10(1):e379. Graham HK, Duan X. PMID: 32267095; PMCID: PMC7541429.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes. Front Mol Neurosci. 2018; 11:385. Laboulaye MA, Duan X, Qiao M, Whitney IE, Sanes JR. PMID: 30405348; PMCID: PMC6206269.
      View in: PubMed   Mentions: 26  
    18. Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold. Neuron. 2018 09 19; 99(6):1145-1154.e6. Duan X, Krishnaswamy A, Laboulaye MA, Liu J, Peng YR, Yamagata M, Toma K, Sanes JR. PMID: 30197236; PMCID: PMC6284407.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    19. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation. Front Mol Neurosci. 2018; 11:142. Yamagata M, Duan X, Sanes JR. PMID: 29760652; PMCID: PMC5936767.
      View in: PubMed   Mentions: 30  
    20. Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Neuron. 2017 Sep 27; 96(1):160-176.e8. Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, Williams ME. PMID: 28957665; PMCID: PMC5634529.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    21. Diverse Central Projection Patterns of Retinal Ganglion Cells. Cell Rep. 2017 02 21; 18(8):2058-2072. Martersteck EM, Hirokawa KE, Evarts M, Bernard A, Duan X, Li Y, Ng L, Oh SW, Ouellette B, Royall JJ, Stoecklin M, Wang Q, Zeng H, Sanes JR, Harris JA. PMID: 28228269; PMCID: PMC5357325.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    22. Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015 Aug 27; 524(7566):466-470. Krishnaswamy A, Yamagata M, Duan X, Hong YK, Sanes JR. PMID: 26287463; PMCID: PMC4552609.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    23. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18; 85(6):1244-56. Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. PMID: 25754821; PMCID: PMC4391013.
      View in: PubMed   Mentions: 286     Fields:    Translation:AnimalsCells
    24. Type II cadherins guide assembly of a direction-selective retinal circuit. Cell. 2014 Aug 14; 158(4):793-807. Duan X, Krishnaswamy A, De la Huerta I, Sanes JR. PMID: 25126785.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    25. Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell. 2012 Mar 02; 148(5):1051-64. Kim JY, Liu CY, Zhang F, Duan X, Wen Z, Song J, Feighery E, Lu B, Rujescu D, St Clair D, Christian K, Callicott JH, Weinberger DR, Song H, Ming GL. PMID: 22385968; PMCID: PMC3294278.
      View in: PubMed   Mentions: 114     Fields:    
    26. Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron. 2011 Nov 17; 72(4):559-71. Kang E, Burdick KE, Kim JY, Duan X, Guo JU, Sailor KA, Jung DE, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra AK, Song H, Ming GL. PMID: 22099459; PMCID: PMC3222865.
      View in: PubMed   Mentions: 55     Fields:    
    27. Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3175-9. Kim PM, Duan X, Huang AS, Liu CY, Ming GL, Song H, Snyder SH. PMID: 20133766; PMCID: PMC2840285.
      View in: PubMed   Mentions: 44     Fields:    
    28. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009 Sep 24; 63(6):761-73. Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL. PMID: 19778506; PMCID: PMC3075620.
      View in: PubMed   Mentions: 159     Fields:    
    29. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14157-62. Faulkner RL, Jang MH, Liu XB, Duan X, Sailor KA, Kim JY, Ge S, Jones EG, Ming GL, Song H, Cheng HJ. PMID: 18780780; PMCID: PMC2544594.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    30. Development of neural stem cell in the adult brain. Curr Opin Neurobiol. 2008 Feb; 18(1):108-15. Duan X, Kang E, Liu CY, Ming GL, Song H. PMID: 18514504; PMCID: PMC2464621.
      View in: PubMed   Mentions: 109     Fields:    
    31. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007 Sep 21; 130(6):1146-58. Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H. PMID: 17825401; PMCID: PMC2002573.
      View in: PubMed   Mentions: 247     Fields:    
    32. Crystal structure of human coactosin-like protein at 1.9 A resolution. Protein Sci. 2004 Nov; 13(11):2845-51. Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z. PMID: 15459340; PMCID: PMC2286586.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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