Xin Duan, PhD

Title(s)Associate Professor, Ophthalmology
SchoolSchool of Medicine
Address1550 Fourth St, #484C
San Francisco CA 94158
Phone415-476-4233
ORCID ORCID Icon0000-0001-5260-8972 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard University, Cambridge, MAPostdoc12/2016Neuroscience
    Johns Hopkins University, Baltimore, MDPh.D.12/2008Neuroscience
    Tsinghua University, BeijingB.S.07/2002Biological Sciences
    UCSF, San Francisco, CA06/2022Diversity, Equity and Inclusion Training
    Collapse Awards and Honors
    Glaucoma Research Foundation 2019  - 2025Catalyst for a Cure Team Award (CFC3)
    Kavli Institute for Fundamental Neuroscience2020  - 2021Kavli Neuroscience Institute Collaborative Award
    The Klingenstein Foundation2018  - 2021Klingenstein-Simons Neuroscience Fellowship
    Whitehall Foundation2018  - 2021Whitehall Neuroscience Scholarship
    Research to Prevent Blindness2017  - 2020Career Development Award
    UCSF Weill Institute of Neuroscience2017  - 2018Trailblazer Award in Neuroscience
    Life Science Research Foundation2010  - 2013HHMI-LSRF Fellowship
    Johns Hopkins University School of Medicine2008Young Investigator Award
    Tsinghua University2002Graduation with Highest Honor

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    MAPPING RETINOTECTAL CIRCUITS FOR VISUAL-EVOKED INNATE BEHAVIORS
    NIH R01NS123912Aug 15, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal Circuits
    NIH R01EY030138Jan 1, 2020 - Dec 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions. J Neurosci. 2024 Jan 31; 44(5). Matcham AC, Toma K, Tsai NY, Sze CJ, Lin PY, Stewart IF, Duan X. PMID: 38123991; PMCID: PMC10860569.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy. Cell Rep. 2023 09 26; 42(9):113038. Zhao M, Toma K, Kinde B, Li L, Patel AK, Wu KY, Lum MR, Tan C, Hooper JE, Kriegstein AR, La Torre A, Liao YJ, Welsbie DS, Hu Y, Han Y, Duan X. PMID: 37624696; PMCID: PMC10591811.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Postsynaptic neuronal activity promotes regeneration of retinal axons. Cell Rep. 2023 05 30; 42(5):112476. Varadarajan SG, Wang F, Dhande OS, Le P, Duan X, Huberman AD. PMID: 37141093; PMCID: PMC10247459.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Coordinated cadherin functions sculpt respiratory motor circuit connectivity. Elife. 2022 12 30; 11. Vagnozzi AN, Moore MT, Lin M, Brozost EM, Kc R, Agarwal A, Schwarz LA, Duan X, Zampieri N, Landmesser LT, Philippidou P. PMID: 36583530; PMCID: PMC9910829.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. Longitudinal in vivo Ca2+ imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level. Proc Natl Acad Sci U S A. 2022 11 29; 119(48):e2206829119. Li L, Feng X, Fang F, Miller DA, Zhang S, Zhuang P, Huang H, Liu P, Liu J, Sredar N, Liu L, Sun Y, Duan X, Goldberg JL, Zhang HF, Hu Y. PMID: 36409915; PMCID: PMC9889883.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Live, die, or regenerate? New insights from multi-omic analyses. Neuron. 2022 08 17; 110(16):2516-2519. Tsai NY, Welsbie DS, Duan X. PMID: 35981522; PMCID: PMC9521179.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin. Nat Neurosci. 2022 05; 25(5):659-674. Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X. PMID: 35524141; PMCID: PMC9172271.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    8. Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener. 2022 03 21; 17(1):23. Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Bovenkamp DE, Calkins DJ. PMID: 35313950; PMCID: PMC8935795.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    9. Oestrogen engages brain MC4R signalling to drive physical activity in female mice. Nature. 2021 11; 599(7883):131-135. Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA. PMID: 34646010; PMCID: PMC9113400.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    10. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33597-33607. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207; PMCID: PMC7777023.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. Molecular mechanisms regulating synaptic specificity and retinal circuit formation. Wiley Interdiscip Rev Dev Biol. 2021 01; 10(1):e379. Graham HK, Duan X. PMID: 32267095; PMCID: PMC7541429.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes. Front Mol Neurosci. 2018; 11:385. Laboulaye MA, Duan X, Qiao M, Whitney IE, Sanes JR. PMID: 30405348; PMCID: PMC6206269.
      View in: PubMed   Mentions: 25  
    13. Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold. Neuron. 2018 09 19; 99(6):1145-1154.e6. Duan X, Krishnaswamy A, Laboulaye MA, Liu J, Peng YR, Yamagata M, Toma K, Sanes JR. PMID: 30197236; PMCID: PMC6284407.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    14. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation. Front Mol Neurosci. 2018; 11:142. Yamagata M, Duan X, Sanes JR. PMID: 29760652; PMCID: PMC5936767.
      View in: PubMed   Mentions: 27  
    15. Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Neuron. 2017 Sep 27; 96(1):160-176.e8. Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, Williams ME. PMID: 28957665; PMCID: PMC5634529.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    16. Diverse Central Projection Patterns of Retinal Ganglion Cells. Cell Rep. 2017 02 21; 18(8):2058-2072. Martersteck EM, Hirokawa KE, Evarts M, Bernard A, Duan X, Li Y, Ng L, Oh SW, Ouellette B, Royall JJ, Stoecklin M, Wang Q, Zeng H, Sanes JR, Harris JA. PMID: 28228269; PMCID: PMC5357325.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    17. Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015 Aug 27; 524(7566):466-470. Krishnaswamy A, Yamagata M, Duan X, Hong YK, Sanes JR. PMID: 26287463; PMCID: PMC4552609.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    18. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18; 85(6):1244-56. Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. PMID: 25754821; PMCID: PMC4391013.
      View in: PubMed   Mentions: 259     Fields:    Translation:AnimalsCells
    19. Type II cadherins guide assembly of a direction-selective retinal circuit. Cell. 2014 Aug 14; 158(4):793-807. Duan X, Krishnaswamy A, De la Huerta I, Sanes JR. PMID: 25126785.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    20. Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell. 2012 Mar 02; 148(5):1051-64. Kim JY, Liu CY, Zhang F, Duan X, Wen Z, Song J, Feighery E, Lu B, Rujescu D, St Clair D, Christian K, Callicott JH, Weinberger DR, Song H, Ming GL. PMID: 22385968; PMCID: PMC3294278.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    21. Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron. 2011 Nov 17; 72(4):559-71. Kang E, Burdick KE, Kim JY, Duan X, Guo JU, Sailor KA, Jung DE, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra AK, Song H, Ming GL. PMID: 22099459; PMCID: PMC3222865.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    22. Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3175-9. Kim PM, Duan X, Huang AS, Liu CY, Ming GL, Song H, Snyder SH. PMID: 20133766; PMCID: PMC2840285.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    23. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009 Sep 24; 63(6):761-73. Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL. PMID: 19778506; PMCID: PMC3075620.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    24. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14157-62. Faulkner RL, Jang MH, Liu XB, Duan X, Sailor KA, Kim JY, Ge S, Jones EG, Ming GL, Song H, Cheng HJ. PMID: 18780780; PMCID: PMC2544594.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    25. Development of neural stem cell in the adult brain. Curr Opin Neurobiol. 2008 Feb; 18(1):108-15. Duan X, Kang E, Liu CY, Ming GL, Song H. PMID: 18514504; PMCID: PMC2464621.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    26. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007 Sep 21; 130(6):1146-58. Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H. PMID: 17825401; PMCID: PMC2002573.
      View in: PubMed   Mentions: 318     Fields:    Translation:AnimalsCells
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