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Arnold Kriegstein, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentNeurology
Address35 Medical Center way
San Fancisco CA 94143
Phone415-476-0766
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    Other Positions
    TitleDirector, Developmental and Stem Cell Biology Program


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    Collapse Overview
    Dr. Kriegstein received BA from Yale University and his MD and PhD degrees from New York University in 1977 where his thesis advisor was Dr. Eric Kandel. He subsequently completed Residency training in Neurology at the Brigham and Women’s Hospital, Children’s Hospital, and Beth Israel Hospital in Boston. He has held academic appointments at Stanford University, Yale University, and Columbia University. In 2004 he joined the Neurology Department at the University of California, San Francisco. He is currently the John Bowes Distinguished Professor in Stem Cell and Tissue Biology and Founding Director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF. Dr. Kriegstein’s own research focuses on the way in which neural stem and progenitor cells in the embryonic brain produce neurons, and ways in which this information can be used for cell based therapies to treat diseases of the nervous system. His lab found that radial glial cells are neuronal stem cells in the developing brain, and also identified a second type of precursor cell produced by radial glial cells that is responsible for generating specific neuronal subtypes. He has recently begun to characterize the progenitor cells within the developing human brain, to determine the genetic profiles of specific progenitor populations, and to explore how these cells contribute to the huge expansion of neuron number that characterizes human cerebral cortex.


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    A Cellular Resolution Census of the Developing Human Brain
    NIH/NIMH U01MH114825Sep 15, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Development and Expansion of the Human Cerebral Cortex
    NIH/NINDS R35NS097305Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Mapping the Developing Human Neocortex by Massively Parallel Single Cell Analysis
    NIH/NIMH U01MH105989Sep 26, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Regulation of Cellular Pathwaysin Human Brain Development
    NIH/NINDS P01NS083513Jul 1, 2014 - Jun 30, 2019
    Role: Co-Investigator
    Stem Cells of the Developing Human Neocortex
    NIH/NINDS R01NS075998Apr 1, 2011 - Mar 31, 2017
    Role: Principal Investigator
    Molecular and cellular mechanism of Microcephaly
    NIH/NINDS R01NS072630Sep 1, 2010 - Jul 31, 2015
    Role: Principal Investigator
    Spinal cord injury: Targeting local inhibition to improve outcome
    NIH/NINDS RC1NS068200Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Neurobiology of Disease Workshop -- Teaching Workshop
    NIH/NINDS R25NS054767May 1, 2006 - Jan 31, 2016
    Role: Co-Principal Investigator
    Proliferation, Specification &Brain Function
    NIH P01NS048120Apr 1, 2004 - Jun 30, 2016
    Role: Co-Investigator
    BIORAD 2-PHOTON LASER SCANNING MICROSCOPY SYSTEM
    NIH/NCRR S10RR013701Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    GLYCINE RECEPTORS AND DISORDERS OF CORTICOGENESIS
    NIH/NINDS R37NS038658Apr 5, 1999 - Mar 31, 2006
    Role: Principal Investigator
    The Physiology of Radial Units in Corticogenesis
    NIH/NINDS R37NS035710Apr 1, 1997 - Jul 31, 2016
    Role: Principal Investigator
    The Physiology of Radial Units in Corticogenesis
    NIH/NINDS R01NS035710Apr 1, 1997 - Aug 31, 2011
    Role: Principal Investigator
    Intercellular Signaling in Neocortical Development
    NIH/NINDS R01NS021223Dec 1, 1984 - Aug 31, 2012
    Role: Principal Investigator
    ONTOGENESIS OF CORTICAL INHIBITION
    NIH/NINDS K07NS000887Jul 1, 1984 - Dec 31, 1989
    Role: Principal Investigator
    Neurobiology of Disease -- Teaching Workshop
    NIH/NINDS R13NS020032Aug 1, 1983 - Oct 31, 2006
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Werling DM, Brand H, An JY, Stone MR, Zhu L, Glessner JT, Collins RL, Dong S, Layer RM, Markenscoff-Papadimitriou E, Farrell A, Schwartz GB, Wang HZ, Currall BB, Zhao X, Dea J, Duhn C, Erdman CA, Gilson MC, Yadav R, Handsaker RE, Kashin S, Klei L, Mandell JD, Nowakowski TJ, Liu Y, Pochareddy S, Smith L, Walker MF, Waterman MJ, He X, Kriegstein A, Rubenstein JL, Sestan N, McCarroll SA, Neale BM, Coon H, Willsey AJ, Buxbaum JD, Daly MJ, State MW, Quinlan AR, Marth GT, Roeder K, Devlin B, Talkowski ME, Sanders SJ. An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. Nat Genet. 2018 Apr 26. PMID: 29700473.
      View in: PubMed
    2. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein A, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15; 555(7696):377-381. PMID: 29513649.
      View in: PubMed
    3. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein A, Lim DA, Aghi M, Okada H, Diaz A. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Genome Biol. 2017 Dec 20; 18(1):234. PMID: 29262845.
      View in: PubMed
    4. Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein A. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science. 2017 12 08; 358(6368):1318-1323. PMID: 29217575.
      View in: PubMed
    5. Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N. The Human Cell Atlas. Elife. 2017 12 05; 6. PMID: 29206104.
      View in: PubMed
    6. Ecker JR, Geschwind DH, Kriegstein A, Ngai J, Osten P, Polioudakis D, Regev A, Sestan N, Wickersham IR, Zeng H. The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas. Neuron. 2017 Nov 01; 96(3):542-557. PMID: 29096072.
      View in: PubMed
    7. Di Lullo E, Kriegstein A. The use of brain organoids to investigate neural development and disease. Nat Rev Neurosci. 2017 10; 18(10):573-584. PMID: 28878372.
      View in: PubMed
    8. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Oldham MC. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2017 Apr 26; 1-13. PMID: 28449024.
      View in: PubMed
    9. Subramanian L, Bershteyn M, Paredes MF, Kriegstein A. Dynamic behaviour of human neuroepithelial cells in the developing forebrain. Nat Commun. 2017 Jan 31; 8:14167. PMID: 28139695.
      View in: PubMed
    10. Bershteyn M, Nowakowski TJ, Pollen AA, Di Lullo E, Nene A, Wynshaw-Boris A, Kriegstein A. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia. Cell Stem Cell. 2017 04 06; 20(4):435-449.e4. PMID: 28111201.
      View in: PubMed
    11. Ostrem B, Di Lullo E, Kriegstein A. oRGs and mitotic somal translocation - a role in development and disease. Curr Opin Neurobiol. 2017 02; 42:61-67. PMID: 27978479.
      View in: PubMed
    12. Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein A, DeRisi JL. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14408-14413. PMID: 27911847.
      View in: PubMed
    13. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein A, Lim DA, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889. PMID: 27888226.
      View in: PubMed
    14. Pollen AA, Kriegstein A. Primate Neurons Flex Their Musclin. Neuron. 2016 Nov 23; 92(4):681-683. PMID: 27883900.
      View in: PubMed
    15. Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein A. Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury. Cell Stem Cell. 2016 10 06; 19(4):544-557. PMID: 27666009.
      View in: PubMed
    16. Nowakowski TJ, Pollen AA, Sandoval-Espinosa C, Kriegstein A. Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development. Neuron. 2016 Sep 21; 91(6):1219-1227. PMID: 27657449.
      View in: PubMed
    17. Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein A, Kosik KS. A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA. Neuron. 2016 06 15; 90(6):1174-1188. PMID: 27263970; PMCID: PMC4911262 [Available on 06/15/17].
    18. Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A. SCell: integrated analysis of single-cell RNA-seq data. Bioinformatics. 2016 07 15; 32(14):2219-20. PMID: 27153637; PMCID: PMC4937196 [Available on 07/15/17].
    19. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein A, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67. PMID: 27081004; PMCID: PMC4831157.
    20. Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Kriegstein A. Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell Stem Cell. 2016 05 05; 18(5):591-6. PMID: 27038591.
      View in: PubMed
    21. Gertz CC, Kriegstein A. Neuronal Migration Dynamics in the Developing Ferret Cortex. J Neurosci. 2015 Oct 21; 35(42):14307-15. PMID: 26490868; PMCID: PMC4683689.
    22. Chen J, Kriegstein A. A GABAergic projection from the zona incerta to cortex promotes cortical neuron development. Science. 2015 Oct 30; 350(6260):554-8. PMID: 26429884.
      View in: PubMed
    23. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein A. Molecular identity of human outer radial glia during cortical development. Cell. 2015 Sep 24; 163(1):55-67. PMID: 26406371; PMCID: PMC4583716.
    24. Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein A. Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Neuron. 2015 Sep 02; 87(5):999-1007. PMID: 26299474; PMCID: PMC4581718.
    25. Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein A, Lim DA. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):439-447. PMID: 25800779; PMCID: PMC4388801.
    26. Clinton BK, Cunningham CL, Kriegstein A, Noctor SC, Martínez-Cerdeño V. Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans. Neurogenesis (Austin). 2014; 1(1):e970905. PMID: 27504470; PMCID: PMC4973586.
    27. Lui JH, Nowakowski TJ, Pollen AA, Javaherian A, Kriegstein A, Oldham MC. Radial glia require PDGFD-PDGFRß signalling in human but not mouse neocortex. Nature. 2014 Nov 13; 515(7526):264-8. PMID: 25391964; PMCID: PMC4231536.
    28. Kriegstein A. Yoshiki Sasai (1962–2014). Neuron. 2014 Sep 17; 83(6):1237-8. PMID: 25364807.
      View in: PubMed
    29. Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein A, Lim DA. The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation. J Neurosci. 2014 Sep 10; 34(37):12560-7. PMID: 25209293; PMCID: PMC4160784.
    30. Kriegstein A. Yoshiki Sasai (1962–2014). Cell Stem Cell. 2014 Sep 04; 15(3):265-6. PMID: 25333080.
      View in: PubMed
    31. Pollen AA, Nowakowski TJ, Shuga J, Wang X, Leyrat AA, Lui JH, Li N, Szpankowski L, Fowler B, Chen P, Ramalingam N, Sun G, Thu M, Norris M, Lebofsky R, Toppani D, Kemp DW, Wong M, Clerkson B, Jones BN, Wu S, Knutsson L, Alvarado B, Wang J, Weaver LS, May AP, Jones RC, Unger MA, Kriegstein A, West JA. Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex. Nat Biotechnol. 2014 Oct; 32(10):1053-8. PMID: 25086649; PMCID: PMC4191988.
    32. Ostrem BE, Lui JH, Gertz CC, Kriegstein A. Control of outer radial glial stem cell mitosis in the human brain. Cell Rep. 2014 Aug 07; 8(3):656-64. PMID: 25088420; PMCID: PMC4127493.
    33. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein A, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. PMID: 24723614; PMCID: PMC4056344.
    34. Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A. Axonal control of the adult neural stem cell niche. Cell Stem Cell. 2014 Apr 03; 14(4):500-11. PMID: 24561083; PMCID: PMC4080817.
    35. Gertz CC, Lui JH, LaMonica BE, Wang X, Kriegstein A. Diverse behaviors of outer radial glia in developing ferret and human cortex. J Neurosci. 2014 Feb 12; 34(7):2559-70. PMID: 24523546; PMCID: PMC3921426.
    36. Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein A, Yamanaka S, Wynshaw-Boris A. Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature. 2014 Mar 06; 507(7490):99-103. PMID: 24413397; PMCID: PMC4030630.
    37. Wu Q, Liu J, Fang A, Li R, Bai Y, Kriegstein A, Wang X. The dynamics of neuronal migration. Adv Exp Med Biol. 2014; 800:25-36. PMID: 24243098.
      View in: PubMed
    38. Hansen DV, Lui JH, Flandin P, Yoshikawa K, Rubenstein JL, Alvarez-Buylla A, Kriegstein A. Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat Neurosci. 2013 Nov; 16(11):1576-87. PMID: 24097039; PMCID: PMC4191718.
    39. Bershteyn M, Kriegstein A. Cerebral organoids in a dish: progress and prospects. Cell. 2013 Sep 26; 155(1):19-20. PMID: 24074857.
      View in: PubMed
    40. Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein A. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell. 2013 May 02; 12(5):573-86. PMID: 23642366; PMCID: PMC3699205.
    41. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein A, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956. PMID: 23658702; PMCID: PMC3641041.
    42. Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Kaplan T, Kriegstein A, Rubin EM, Ovcharenko I, Pennacchio LA, Rubenstein JL. A high-resolution enhancer atlas of the developing telencephalon. Cell. 2013 Feb 14; 152(4):895-908. PMID: 23375746; PMCID: PMC3660042.
    43. LaMonica BE, Lui JH, Hansen DV, Kriegstein A. Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex. Nat Commun. 2013; 4:1665. PMID: 23575669; PMCID: PMC3625970.
    44. Woodworth MB, Custo Greig L, Kriegstein A, Macklis JD. SnapShot: cortical development. Cell. 2012 Nov 09; 151(4):918-918.e1. PMID: 23141546; PMCID: PMC3694327.
    45. Plath K, Srivastava D, Alvarez-Buylla A, Tanaka EM, Kriegstein A. Stem cells in the land of the rising sun: ISSCR 2012. Cell Stem Cell. 2012 Nov 02; 11(5):607-14. PMID: 23122288.
      View in: PubMed
    46. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron. 2012 May 24; 74(4):663-75. PMID: 22632725; PMCID: PMC3361692.
    47. LaMonica BE, Lui JH, Wang X, Kriegstein A. OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease. Curr Opin Neurobiol. 2012 Oct; 22(5):747-53. PMID: 22487088; PMCID: PMC3402619.
    48. Harwell CC, Parker PR, Gee SM, Okada A, McConnell SK, Kreitzer AC, Kriegstein A. Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron. 2012 Mar 22; 73(6):1116-26. PMID: 22445340; PMCID: PMC3551478.
    49. Wang X, Lui JH, Kriegstein A. Orienting fate: spatial regulation of neurogenic divisions. Neuron. 2011 Oct 20; 72(2):191-3. PMID: 22017981; PMCID: PMC3220621.
    50. Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein A, Alvarez-Buylla A. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Neuron. 2011 Jul 28; 71(2):250-62. PMID: 21791285; PMCID: PMC3346180.
    51. Lui JH, Hansen DV, Kriegstein A. Development and evolution of the human neocortex. Cell. 2011 Jul 08; 146(1):18-36. PMID: 21729779; PMCID: PMC3610574.
    52. Hansen DV, Rubenstein JL, Kriegstein A. Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron. 2011 May 26; 70(4):645-60. PMID: 21609822; PMCID: PMC3124445.
    53. Wang X, Tsai JW, LaMonica B, Kriegstein A. A new subtype of progenitor cell in the mouse embryonic neocortex. Nat Neurosci. 2011 May; 14(5):555-61. PMID: 21478886; PMCID: PMC3083489.
    54. Rowitch DH, Kriegstein A. Developmental genetics of vertebrate glial-cell specification. Nature. 2010 Nov 11; 468(7321):214-22. PMID: 21068830.
      View in: PubMed
    55. Tsai JW, Lian WN, Kemal S, Kriegstein A, Vallee RB. Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells. Nat Neurosci. 2010 Dec; 13(12):1463-71. PMID: 21037580; PMCID: PMC3059207.
    56. Wang DD, Kriegstein A. Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits. Cereb Cortex. 2011 Mar; 21(3):574-87. PMID: 20624842; PMCID: PMC3041010.
    57. Elias LA, Turmaine M, Parnavelas JG, Kriegstein A. Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons. J Neurosci. 2010 May 19; 30(20):7072-7. PMID: 20484649; PMCID: PMC2883285.
    58. Hansen DV, Lui JH, Parker PR, Kriegstein A. Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature. 2010 Mar 25; 464(7288):554-561. PMID: 20154730.
      View in: PubMed
    59. Martínez-Cerdeño V, Noctor SC, Espinosa A, Ariza J, Parker P, Orasji S, Daadi MM, Bankiewicz K, Alvarez-Buylla A, Kriegstein A. Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats. Cell Stem Cell. 2010 Mar 05; 6(3):238-50. PMID: 20207227; PMCID: PMC4075336.
    60. Nicholas CR, Kriegstein A. Regenerative medicine: Cell reprogramming gets direct. Nature. 2010 Feb 25; 463(7284):1031-2. PMID: 20182502.
      View in: PubMed
    61. Lo B, Parham L, Cedars M, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Rao R, Roberts C, Wagner R. Research ethics. NIH guidelines for stem cell research and gamete donors. Science. 2010 Feb 19; 327(5968):962-3. PMID: 20167773; PMCID: PMC2892655.
    62. Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R. Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning. Cell Stem Cell. 2010 Jan 08; 6(1):16-20. PMID: 20085739; PMCID: PMC4035242.
    63. Bultje RS, Castaneda-Castellanos DR, Jan LY, Jan YN, Kriegstein A, Shi SH. Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 2009 Jul 30; 63(2):189-202. PMID: 19640478; PMCID: PMC2736606.
    64. Javaherian A, Kriegstein A. A stem cell niche for intermediate progenitor cells of the embryonic cortex. Cereb Cortex. 2009 Jul; 19 Suppl 1:i70-7. PMID: 19346271; PMCID: PMC2693531.
    65. Kriegstein A, Pitkänen A. Commentary: the prospect of cell-based therapy for epilepsy. Neurotherapeutics. 2009 Apr; 6(2):295-9. PMID: 19332322.
      View in: PubMed
    66. Lo B, Parham L, Broom C, Cedars M, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Oberman M, Roberts C, Wagner R. Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns. Cell Stem Cell. 2009 Feb 06; 4(2):115-23. PMID: 19200800.
      View in: PubMed
    67. Wang DD, Kriegstein A. Defining the role of GABA in cortical development. J Physiol. 2009 May 01; 587(Pt 9):1873-9. PMID: 19153158; PMCID: PMC2689328.
    68. Kriegstein A, Alvarez-Buylla A. The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci. 2009; 32:149-84. PMID: 19555289; PMCID: PMC3086722.
    69. Elias LA, Potter GB, Kriegstein A. A time and a place for nkx2-1 in interneuron specification and migration. Neuron. 2008 Sep 11; 59(5):679-82. PMID: 18786351; PMCID: PMC2632973.
    70. Wang DD, Kriegstein A, Ben-Ari Y. GABA regulates stem cell proliferation before nervous system formation. Epilepsy Curr. 2008 Sep-Oct; 8(5):137-9. PMID: 18852839; PMCID: PMC2566617.
    71. Milosevic A, Noctor SC, Martinez-Cerdeno V, Kriegstein A, Goldman JE. Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation. Mol Cell Neurosci. 2008 Nov; 39(3):324-34. PMID: 18718868; PMCID: PMC2593080.
    72. Wang DD, Kriegstein A. GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation. J Neurosci. 2008 May 21; 28(21):5547-58. PMID: 18495889; PMCID: PMC2684685.
    73. LoTurco JJ, Kriegstein A. Manipulating midbrain stem cell self-renewal. Cell Stem Cell. 2008 May 08; 2(5):405-6. PMID: 18462687; PMCID: PMC2601722.
    74. Noctor SC, Martínez-Cerdeño V, Kriegstein A. Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis. J Comp Neurol. 2008 May 01; 508(1):28-44. PMID: 18288691; PMCID: PMC2635107.
    75. Elias LA, Kriegstein A. Gap junctions: multifaceted regulators of embryonic cortical development. Trends Neurosci. 2008 May; 31(5):243-50. PMID: 18403031; PMCID: PMC2610634.
    76. Lo B, Kriegstein A, Grady D. Clinical trials in stem cell transplantation: guidelines for scientific and ethical review. Clin Trials. 2008; 5(5):517-22. PMID: 18827044.
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    77. Elias LA, Wang DD, Kriegstein A. Gap junction adhesion is necessary for radial migration in the neocortex. Nature. 2007 Aug 23; 448(7156):901-7. PMID: 17713529.
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    78. Walantus W, Castaneda D, Elias L, Kriegstein A. In utero intraventricular injection and electroporation of E15 mouse embryos. J Vis Exp. 2007; (6):239. PMID: 18997887; PMCID: PMC2557118.
    79. Kriegstein A. Cortical neurogenesis: transitioning from advances in the laboratory to cell-based therapies. J Vis Exp. 2007; (6):241. PMID: 18997889; PMCID: PMC2557109.
    80. Walantus W, Elias L, Kriegstein A. In utero intraventricular injection and electroporation of E16 rat embryos. J Vis Exp. 2007; (6):236. PMID: 18997884; PMCID: PMC2557119.
    81. Elias L, Kriegstein A. Organotypic slice culture of E18 rat brains. J Vis Exp. 2007; (6):235. PMID: 18997883; PMCID: PMC2557113.
    82. Noctor SC, Martínez-Cerdeño V, Kriegstein A. Contribution of intermediate progenitor cells to cortical histogenesis. Arch Neurol. 2007 May; 64(5):639-42. PMID: 17502462.
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    83. Noctor SC, Martinez-Cerdeño V, Kriegstein A. Neural stem and progenitor cells in cortical development. Novartis Found Symp. 2007; 288:59-73; discussion 73-8, 96-8. PMID: 18494252.
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    84. Martínez-Cerdeño V, Noctor SC, Kriegstein A. Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex. Eur J Neurosci. 2006 Dec; 24(12):3475-88. PMID: 17229096.
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    85. Kriegstein A, Noctor S, Martínez-Cerdeño V. Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion. Nat Rev Neurosci. 2006 Nov; 7(11):883-90. PMID: 17033683.
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    86. Kriegstein A, Parnavelas JG. Progress in corticogenesis. Cereb Cortex. 2006 Jul; 16 Suppl 1:i1-2. PMID: 16766695.
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    87. Martínez-Cerdeño V, Noctor SC, Kriegstein A. The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex. Cereb Cortex. 2006 Jul; 16 Suppl 1:i152-61. PMID: 16766701.
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    88. Castañeda-Castellanos DR, Flint AC, Kriegstein A. Blind patch clamp recordings in embryonic and adult mammalian brain slices. Nat Protoc. 2006; 1(2):532-42. PMID: 17406279.
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    89. Butt SJ, Fuccillo M, Nery S, Noctor S, Kriegstein A, Corbin JG, Fishell G. The temporal and spatial origins of cortical interneurons predict their physiological subtype. Neuron. 2005 Nov 23; 48(4):591-604. PMID: 16301176.
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    90. Lo B, Zettler P, Cedars MI, Gates E, Kriegstein A, Oberman M, Reijo Pera R, Wagner RM, Wuerth MT, Wolf LE, Yamamoto KR. A new era in the ethics of human embryonic stem cell research. Stem Cells. 2005 Nov-Dec; 23(10):1454-9. PMID: 16293581.
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    91. Tsai JW, Chen Y, Kriegstein A, Vallee RB. LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages. J Cell Biol. 2005 Sep 12; 170(6):935-45. PMID: 16144905; PMCID: PMC2171430.
    92. Kriegstein A. GABA puts the brake on stem cells. Nat Neurosci. 2005 Sep; 8(9):1132-3. PMID: 16127444.
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    93. Fishell G, Kriegstein A. Cortical development: new concepts. Neuron. 2005 May 05; 46(3):361-2. PMID: 15882631.
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    94. Kriegstein A. Constructing circuits: neurogenesis and migration in the developing neocortex. Epilepsia. 2005; 46 Suppl 7:15-21. PMID: 16201991.
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    95. Weissman TA, Riquelme PA, Ivic L, Flint AC, Kriegstein A. Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex. Neuron. 2004 Sep 02; 43(5):647-61. PMID: 15339647.
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    96. Castañeda-Castellanos DR, Kriegstein A. Controlling neuron number: does Numb do the math? Nat Neurosci. 2004 Aug; 7(8):793-4. PMID: 15280888.
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    97. Kriegstein A, Noctor SC. Patterns of neuronal migration in the embryonic cortex. Trends Neurosci. 2004 Jul; 27(7):392-9. PMID: 15219738.
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    98. Noctor SC, Martínez-Cerdeño V, Ivic L, Kriegstein A. Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nat Neurosci. 2004 Feb; 7(2):136-44. PMID: 14703572.
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    99. Ivic L, Sands TT, Fishkin N, Nakanishi K, Kriegstein A, Strømgaard K. Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J Biol Chem. 2003 Dec 05; 278(49):49279-85. PMID: 14504293.
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    100. Kriegstein A, Götz M. Radial glia diversity: a matter of cell fate. Glia. 2003 Jul; 43(1):37-43. PMID: 12761864.
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    101. Kriegstein A, Parnavelas JG. Changing concepts of cortical development. Cereb Cortex. 2003 Jun; 13(6):541. PMID: 12764026.
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    102. Weissman T, Noctor SC, Clinton BK, Honig LS, Kriegstein A. Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration. Cereb Cortex. 2003 Jun; 13(6):550-9. PMID: 12764028.
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    103. Fishell G, Kriegstein A. Neurons from radial glia: the consequences of asymmetric inheritance. Curr Opin Neurobiol. 2003 Feb; 13(1):34-41. PMID: 12593980.
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    104. Owens DF, Kriegstein A. Developmental neurotransmitters? Neuron. 2002 Dec 19; 36(6):989-91. PMID: 12495613.
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    105. Owens DF, Kriegstein A. Is there more to GABA than synaptic inhibition? Nat Rev Neurosci. 2002 Sep; 3(9):715-27. PMID: 12209120.
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    106. Benardete EA, Kriegstein A. Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex. Epilepsia. 2002 Sep; 43(9):970-82. PMID: 12199722.
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    107. Noctor SC, Flint AC, Weissman TA, Wong WS, Clinton BK, Kriegstein A. Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J Neurosci. 2002 Apr 15; 22(8):3161-73. PMID: 11943818.
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