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Jon Levine, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentOral & Maxillofacial Surgery
Address513 Parnassus Ave, Med Sci
San Francisco CA 94122
Phone415-476-5108
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1978 Medicine
    University of California, San FranciscoM.S.1976 Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Vascular Pain Mechanisms
    NIH/NINDS R01NS085831Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Nociceptor mechanisms in the transition from acute to chronic pain
    NIH/NINDS R01NS084545Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Acute-to-Chronic Transition in Ergonomic Muscle Pain: Nociceptor Mechanisms
    NIH/NIAMS R01AR063312Mar 5, 2013 - Jan 31, 2023
    Role: Principal Investigator
    Mechanisms of Interactions of Alcohol Abuse HIV Neuropathogenesis
    NIH/NIAAA R01AA017384Sep 15, 2008 - May 31, 2014
    Role: Principal Investigator
    Receptors and Second Messengers for Pain and Analgesia
    NIH/NINDS P01NS053709Sep 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Mechanisms and Risk Factors in Musculoskeletal Pain
    NIH/NIAMS R01AR054635Aug 1, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Modeling Kappa Opioid Analgesic Mechanisms in Chronic Orofacial Pain Disorders
    NIH/NIDCR R01DE018526Aug 1, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Integrin family of proteins in acute and chronic pain
    NIH/NINDS R01NS053880May 17, 2006 - Feb 28, 2011
    Role: Principal Investigator
    Sex dimorphism in neuroendocrine control of inflammation
    NIH/NIAMS R01AR052106May 16, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Ethanol-induced symptomatic peripheral neuropathy
    NIH/NIAAA R01AA013875Aug 1, 2004 - May 31, 2010
    Role: Principal Investigator
    Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    NIH/NIAMS R01AR048821Jul 1, 2002 - Aug 31, 2014
    Role: Principal Investigator
    Antiviral Nucleoside-Induced Neuropathic Pain Mechanisms
    NIH/NINDS R01NS042546Sep 30, 2001 - Jul 31, 2005
    Role: Principal Investigator
    SEX DIFFERENCES IN INFLAMMATORY PAIN
    NIH/NINR R01NR004880Aug 15, 1998 - May 31, 2004
    Role: Principal Investigator
    Gender and Sex Hormones and Opioid Analgesia
    NIH/NINR R01NR003923Sep 30, 1994 - Jan 31, 2008
    Role: Principal Investigator
    Trigeminal Pain, Mechanisms and Control
    NIH/NIDCR P01DE008973Sep 1, 1990 - Aug 31, 2007
    Role: Principal Investigator
    TRIGEMINAL PAIN--MECHANISMS AND CONTROL
    NIH/NIDCR P50DE008973Sep 1, 1990 - Feb 29, 1996
    Role: Principal Investigator
    NEURAL MECHANISMS OF PAIN AND HYPERALGESIA
    NIH/NINDS R01NS021647Jul 1, 1985 - Mar 31, 2003
    Role: Principal Investigator
    MECHANISMS OF PAIN AND ANALGESIA
    NIH/NINDS P50NS021445Jan 1, 1985 - Dec 31, 2005
    Role: Co-Investigator
    NEURAL/ENDOCRINE MEDIATED AUTOREGULATION OF INFLAMMATION
    NIH/NIAMS R01AR032634Aug 1, 1983 - Mar 31, 2006
    Role: Principal Investigator
    NEURONAL MODULATION OF ARTHRITIC JOINT INJURY
    NIH/NIAMS R55AR032634Aug 1, 1983 - Aug 31, 1995
    Role: Principal Investigator
    SYNOVIAL NOCICEPTORS IN EXPERIMENTAL ARTHRITIS
    NIH/NIADDK R01AM032634Aug 1, 1983 - Jul 31, 1987
    Role: Principal Investigator
    FACTORS AFFECTING DENTAL POSTOPERATIVE PAIN
    NIH/NIDCR R01DE005369Jul 1, 1979 - Jun 30, 1990
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Singh KP, Kober KM, Dhruva AA, Flowers E, Paul SM, Hammer MJ, Cartwright F, Wright F, Conley YP, Levine J, Miaskowski C. Risk Factors Associated With Chemotherapy-Induced Nausea in the Week Prior to the Next Cycle and Impact of Nausea on Quality of Life Outcomes. J Pain Symptom Manage. 2018 May 29. PMID: 29857180.
      View in: PubMed
    2. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine J, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 May 15. PMID: 29765159.
      View in: PubMed
    3. Knisely MR, Conley YP, Kober KM, Smoot B, Paul SM, Levine J, Miaskowski C. Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes Following Breast Cancer Surgery. J Pain. 2018 Apr 30. PMID: 29723560.
      View in: PubMed
    4. Tantoy IY, Cooper BA, Dhruva A, Cataldo J, Paul SM, Conley YP, Hammer M, Kober KM, Levine J, Miaskowski C. Quality of life of patients with gastrointestinal cancers undergoing chemotherapy. Qual Life Res. 2018 Apr 21. PMID: 29679368.
      View in: PubMed
    5. Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine J. Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors. J Pain Symptom Manage. 2018 Mar 07. PMID: 29524582.
      View in: PubMed
    6. Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine J, Wu C. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 Apr 04; 38(14):3394-3413. PMID: 29483280.
      View in: PubMed
    7. Alvarez P, Green PG, Levine J. Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats. J Pain. 2018 Feb 09. PMID: 29432863.
      View in: PubMed
    8. Araldi D, Khomula EV, Ferrari LF, Levine J. Fentanyl Induces Rapid Onset Hyperalgesic Priming: Type I at Peripheral and Type II at Central Nociceptor Terminals. J Neurosci. 2018 Feb 28; 38(9):2226-2245. PMID: 29431655.
      View in: PubMed
    9. Araldi D, Ferrari LF, Levine J. Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II). Pain. 2018 Jan 11. PMID: 29447132.
      View in: PubMed
    10. Mazor M, Cataldo JK, Lee K, Dhruva A, Cooper B, Paul SM, Topp K, Smoot BJ, Dunn LB, Levine J, Conley YP, Miaskowski C. Differences in symptom clusters before and twelve months after breast cancer surgery. Eur J Oncol Nurs. 2018 Feb; 32:63-72. PMID: 29353634.
      View in: PubMed
    11. Mazor M, Lee K, Dhruva A, Cataldo JK, Paul SM, Melisko M, Smoot BJ, Levine J, Elboim C, Conley YP, Miaskowksi C. Menopausal-Related Symptoms in Women One Year After Breast Cancer Surgery. J Pain Symptom Manage. 2018 Apr; 55(4):1138-1151.e1. PMID: 29221848.
      View in: PubMed
    12. Ferrari LF, Khomula EV, Araldi D, Levine J. CD44 Signaling Mediates High Molecular Weight Hyaluronan-Induced Antihyperalgesia. J Neurosci. 2018 Jan 10; 38(2):308-321. PMID: 29175954.
      View in: PubMed
    13. Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine J. Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life. J Cancer Surviv. 2017 Nov 20. PMID: 29159795.
      View in: PubMed
    14. Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine J. Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs. 2018 Feb; 32:1-11. PMID: 29353626.
      View in: PubMed
    15. Jeffery ND, Harcourt-Brown TR, Barker AK, Levine J. Choices and Decisions in Decompressive Surgery for Thoracolumbar Intervertebral Disk Herniation. Vet Clin North Am Small Anim Pract. 2018 Jan; 48(1):169-186. PMID: 29074335.
      View in: PubMed
    16. Tantoy IY, Cooper BA, Dhruva A, Cataldo J, Paul SM, Conley YP, Hammer M, Wright F, Dunn LB, Levine J, Miaskowski C. Changes in the Occurrence, Severity, and Distress of Symptoms in Patients With Gastrointestinal Cancers Receiving Chemotherapy. J Pain Symptom Manage. 2018 Mar; 55(3):808-834. PMID: 29051114.
      View in: PubMed
    17. Moran EV, Reid A, Levine J. Population genetics and adaptation to climate along elevation gradients in invasive Solidago canadensis. PLoS One. 2017; 12(9):e0185539. PMID: 28957402.
      View in: PubMed
    18. Flowers E, Miaskowski C, Conley Y, Hammer MJ, Levine J, Mastick J, Paul S, Wright F, Kober K. Differential expression of genes and differentially perturbed pathways associated with very high evening fatigue in oncology patients receiving chemotherapy. Support Care Cancer. 2018 Mar; 26(3):739-750. PMID: 28944404.
      View in: PubMed
    19. Mazor M, Cataldo JK, Lee K, Dhruva A, Paul SM, Smoot BJ, Dunn LB, Levine J, Mastick J, Conley YP, Miaskowski C. Influence of Menopausal Status on the Symptom Experience of Women Before Breast Cancer Surgery. Cancer Nurs. 2017 Sep 23. PMID: 28945634.
      View in: PubMed
    20. Alexander K, Conley YP, Levine J, Cooper BA, Paul SM, Mastick J, West C, Miaskowski C. Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer. J Pain Symptom Manage. 2017 Sep 23. PMID: 28947144.
      View in: PubMed
    21. Sullivan CW, Leutwyler H, Dunn LB, Cooper BA, Paul SM, Levine J, Hammer M, Conley YP, Miaskowski CA. Stability of Symptom Clusters in Patients With Breast Cancer Receiving Chemotherapy. J Pain Symptom Manage. 2018 Jan; 55(1):39-55. PMID: 28838866.
      View in: PubMed
    22. Papachristou N, Barnaghi P, Cooper BA, Hu X, Maguire R, Apostolidis K, Armes J, Conley YP, Hammer M, Katsaragakis S, Kober KM, Levine J, McCann L, Patiraki E, Paul SM, Ream E, Wright F, Miaskowski C. Congruence Between Latent Class and K-Modes Analyses in the Identification of Oncology Patients With Distinct Symptom Experiences. J Pain Symptom Manage. 2018 Feb; 55(2):318-333.e4. PMID: 28859882.
      View in: PubMed
    23. Langford DJ, Cooper B, Paul S, Humphreys J, Keagy C, Conley YP, Hammer MJ, Levine J, Wright F, Melisko M, Miaskowski C, Dunn LB. Evaluation of coping as a mediator of the relationship between stressful life events and cancer-related distress. Health Psychol. 2017 12; 36(12):1147-1160. PMID: 28825498.
      View in: PubMed
    24. Miaskowski C, Conley YP, Mastick J, Paul SM, Cooper BA, Levine J, Knisely M, Kober KM. Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy. J Pain Symptom Manage. 2017 Sep; 54(3):305-316.e3. PMID: 28797847.
      View in: PubMed
    25. Alvarez P, Bogen O, Green PG, Levine J. Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat. Pain. 2017 Aug; 158(8):1481-1488. PMID: 28628078.
      View in: PubMed
    26. Stephens KE, Levine J, Aouizerat BE, Paul SM, Abrams G, Conley YP, Miaskowski C. Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery. Cytokine. 2017 11; 99:203-213. PMID: 28764974.
      View in: PubMed
    27. Levine J, Cohen ND, Fandel TM, Levine GJ, Mankin J, Griffin JF, Kerwin SC, Boudreau CE, Trivedi A, Noble-Haeusslein LJ. Early Blockade of Matrix Metalloproteinases in Spinal-Cord-Injured Dogs Results in a Long-Term Increase in Bladder Compliance. J Neurotrauma. 2017 Sep 15; 34(18):2656-2667. PMID: 28520505.
      View in: PubMed
    28. Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Oh SP, Karas RH, Kapur NK. Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure. Cardiovasc Pathol. 2017 Nov - Dec; 31:26-33. PMID: 28820968.
      View in: PubMed
    29. Ferrari LF, Araldi D, Green P, Levine J. Age-dependent sexual dimorphism in susceptibility to develop chronic pain in the rat. Neuroscience. 2017 Jul 01. PMID: 28676241.
      View in: PubMed
    30. Araldi D, Ferrari LF, Levine J. Hyperalgesic priming (type II) induced by repeated opioid exposure: maintenance mechanisms. Pain. 2017 Jul; 158(7):1204-1216. PMID: 28306605.
      View in: PubMed
    31. Morgan S, Cooper B, Paul S, Hammer MJ, Conley YP, Levine J, Miaskowski C, Dunn LB. Association of Personality Profiles with Depressive, Anxiety, and Cancer-related Symptoms in Patients Undergoing Chemotherapy. Pers Individ Dif. 2017 Oct 15; 117:130-138. PMID: 29479128.
      View in: PubMed
    32. Wong ML, Cooper BA, Paul SM, Levine J, Conley YP, Wright F, Hammer M, Miaskowski C. Differences in Symptom Clusters Identified Using Ratings of Symptom Occurrence vs. Severity in Lung Cancer Patients Receiving Chemotherapy. J Pain Symptom Manage. 2017 Aug; 54(2):194-203. PMID: 28533161.
      View in: PubMed
    33. Wright F, Cooper BA, Conley YP, Hammer MJ, Chen LM, Paul SM, Levine J, Miaskowski C, Kober KM. Distinct Evening Fatigue Profiles in Oncology Outpatients Receiving Chemotherapy. Fatigue. 2017; 5(3):131-144. PMID: 29725554.
      View in: PubMed
    34. Ward Sullivan C, Leutwyler H, Dunn LB, Cooper BA, Paul SM, Conley YP, Levine J, Miaskowski CA. Differences in symptom clusters identified using symptom occurrence rates versus severity ratings in patients with breast cancer undergoing chemotherapy. Eur J Oncol Nurs. 2017 Jun; 28:122-132. PMID: 28478849.
      View in: PubMed
    35. Masciarelli AE, Griffin JF, Fosgate GT, Hecht S, Mankin JM, Holmes SP, Platt SR, Kent M, Pancotto TE, Chen AV, Levine J. Evaluation of magnetic resonance imaging for the differentiation of inflammatory, neoplastic, and vascular intradural spinal cord diseases in the dog. Vet Radiol Ultrasound. 2017 Jul; 58(4):444-453. PMID: 28421647.
      View in: PubMed
    36. Mark S, Cataldo J, Dhruva A, Paul SM, Chen LM, Hammer MJ, Levine J, Wright F, Melisko M, Lee K, Conley YP, Miaskowski C. Modifiable and non-modifiable characteristics associated with sleep disturbance in oncology outpatients during chemotherapy. Support Care Cancer. 2017 08; 25(8):2485-2494. PMID: 28281049.
      View in: PubMed
    37. Smoot B, Kober KM, Paul SM, Levine J, Abrams G, Mastick J, Topp K, Conley YP, Miaskowski CA. Potassium Channel Candidate Genes Predict the Development of Secondary Lymphedema Following Breast Cancer Surgery. Nurs Res. 2017 Mar/Apr; 66(2):85-94. PMID: 28252570.
      View in: PubMed
    38. Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Karas RH, Oh SP, Kapur NK. Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling. Heart Vessels. 2017 May; 32(5):628-636. PMID: 28213819.
      View in: PubMed
    39. Wong ML, Paul SM, Cooper BA, Dunn LB, Hammer MJ, Conley YP, Wright F, Levine J, Walter LC, Cartwright F, Miaskowski C. Predictors of the multidimensional symptom experience of lung cancer patients receiving chemotherapy. Support Care Cancer. 2017 06; 25(6):1931-1939. PMID: 28160076.
      View in: PubMed
    40. Tantoy IY, Dhruva A, Cataldo J, Venook A, Cooper BA, Paul SM, Levine J, Conley YP, Cartwright F, Lee K, Wright F, Miaskowski C. Differences in symptom occurrence, severity, and distress ratings between patients with gastrointestinal cancers who received chemotherapy alone or chemotherapy with targeted therapy. J Gastrointest Oncol. 2017 Feb; 8(1):109-126. PMID: 28280616.
      View in: PubMed
    41. Khomula EV, Ferrari LF, Araldi D, Levine J. Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming. J Neurosci. 2017 Feb 22; 37(8):2032-2044. PMID: 28115480.
      View in: PubMed
    42. Wright F, Hammer M, Paul SM, Aouizerat BE, Kober KM, Conley YP, Cooper BA, Dunn LB, Levine J, DEramo Melkus G, Miaskowski C. Inflammatory pathway genes associated with inter-individual variability in the trajectories of morning and evening fatigue in patients receiving chemotherapy. Cytokine. 2017 03; 91:187-210. PMID: 28110208.
      View in: PubMed
    43. Ferrari LF, Araldi D, Levine J. Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor a in the Rat. J Pain. 2017 May; 18(5):574-582. PMID: 28089711.
      View in: PubMed
    44. Abid H, Kober KM, Smoot B, Paul SM, Hammer M, Levine J, Lee K, Wright F, Cooper BA, Conley YP, Miaskowski C. Common and Distinct Characteristics Associated With Trajectories of Morning and Evening Energy in Oncology Patients Receiving Chemotherapy. J Pain Symptom Manage. 2017 May; 53(5):887-900.e2. PMID: 28063861.
      View in: PubMed
    45. Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine J. Chemotherapy-Induced Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2017 Aug; 54(2):204-218.e2. PMID: 28063866.
      View in: PubMed
    46. Araldi D, Ferrari LF, Green P, Levine J. Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan. Neuroscience. 2017 Mar 06; 344:394-405. PMID: 28040566.
      View in: PubMed
    47. Shih J, Leutwyler H, Ritchie C, Paul SM, Levine J, Cooper B, Wright F, Conley YP, Miaskowski C. Characteristics associated with inter-individual differences in the trajectories of self-reported attentional function in oncology outpatients receiving chemotherapy. Support Care Cancer. 2017 03; 25(3):783-793. PMID: 27766422.
      View in: PubMed
    48. Colley A, Halpern J, Paul S, Micco G, Lahiff M, Wright F, Levine J, Mastick J, Hammer MJ, Miaskowski C, Dunn LB. Factors associated with oncology patients' involvement in shared decision making during chemotherapy. Psychooncology. 2017 Nov; 26(11):1972-1979. PMID: 27649058.
      View in: PubMed
    49. Eshragh J, Dhruva A, Paul SM, Cooper BA, Mastick J, Hamolsky D, Levine J, Miaskowski C, Kober KM. Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery. J Pain Symptom Manage. 2017 01; 53(1):67-84.e7. PMID: 27720787.
      View in: PubMed
    50. Kober KM, Smoot B, Paul SM, Cooper BA, Levine J, Miaskowski C. Polymorphisms in Cytokine Genes Are Associated With Higher Levels of Fatigue and Lower Levels of Energy in Women After Breast Cancer Surgery. J Pain Symptom Manage. 2016 11; 52(5):695-708.e4. PMID: 27664835.
      View in: PubMed
    51. Ferrari LF, Bogen O, Green P, Levine J. Contribution of Piezo2 to Endothelium-Dependent Pain. Mol Pain. 2015 01; 11. PMID: 27655920.
      View in: PubMed
    52. Smoot B, Paul SM, Aouizerat BE, Dunn L, Elboim C, Schmidt B, Hamolsky D, Levine J, Abrams G, Mastick J, Topp K, Miaskowski C. Predictors of Altered Upper Extremity Function During the First Year After Breast Cancer Treatment. Am J Phys Med Rehabil. 2016 Sep; 95(9):639-55. PMID: 26829093; PMCID: PMC4967035 [Available on 09/01/17].
    53. Stout Steele MW, Hodshon AW, Hopkins AL, Tracy GM, Cohen ND, Kerwin SC, Boudreau CE, Thomas WB, Mankin JM, Levine J. Multi-Center Retrospective Evaluation of Screw and Polymethylmethacrylate Constructs for Atlantoaxial Fixation in Dogs. Vet Surg. 2016 Oct; 45(7):909-915. PMID: 27580972.
      View in: PubMed
    54. Ferrari LF, Khomula EV, Araldi D, Levine J. Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat. Sci Rep. 2016 08 08; 6:31221. PMID: 27499186.
      View in: PubMed
    55. Araldi D, Ferrari LF, Levine J. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain. 2016 08; 157(8):1773-82. PMID: 27075428.
      View in: PubMed
    56. Bischel LE, Ritchie C, Kober KM, Paul SM, Cooper BA, Chen LM, Levine J, Hammer M, Wright F, Miaskowski C. Age differences in fatigue, decrements in energy, and sleep disturbance in oncology patients receiving chemotherapy. Eur J Oncol Nurs. 2016 Aug; 23:115-23. PMID: 27456383; PMCID: PMC4968953 [Available on 08/01/17].
    57. Kurian JR, Louis S, Keen KL, Wolfe A, Terasawa E, Levine J. The Methylcytosine Dioxygenase Ten-Eleven Translocase-2 (tet2) Enables Elevated GnRH Gene Expression and Maintenance of Male Reproductive Function. Endocrinology. 2016 09; 157(9):3588-603. PMID: 27384303; PMCID: PMC5007894 [Available on 09/01/17].
    58. Russell RL, Levine J, Jeffery ND, Young C, Mondragon A, Lee B, Boudreau CE, Welsh CJ, Levine GJ. Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury. BMC Neurosci. 2016 06 10; 17(1):31. PMID: 27287721; PMCID: PMC4901514.
    59. LeBlanc AK, Mazcko C, Brown DE, Koehler JW, Miller AD, Miller CR, Bentley RT, Packer RA, Breen M, Boudreau CE, Levine J, Simpson RM, Halsey C, Kisseberth W, Rossmeisl JH, Dickinson PJ, Fan TM, Corps K, Aldape K, Puduvalli V, Pluhar GE, Gilbert MR. Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients. Neuro Oncol. 2016 09; 18(9):1209-18. PMID: 27179361; PMCID: PMC4999002 [Available on 09/01/17].
    60. Posternak V, Dunn LB, Dhruva A, Paul SM, Luce J, Mastick J, Levine J, Aouizerat BE, Hammer M, Wright F, Miaskowski C. Differences in demographic, clinical, and symptom characteristics and quality of life outcomes among oncology patients with different types of pain. Pain. 2016 Apr; 157(4):892-900. PMID: 26683234; PMCID: PMC4939771 [Available on 04/01/17].
    61. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. 2016 Apr; 157(4):901-9. PMID: 26683237.
      View in: PubMed
    62. Kober KM, Dunn L, Mastick J, Cooper B, Langford D, Melisko M, Venook A, Chen LM, Wright F, Hammer M, Schmidt BL, Levine J, Miaskowski C, Aouizerat BE. Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer. Biol Res Nurs. 2016 07; 18(4):370-85. PMID: 26957308.
      View in: PubMed
    63. Araldi D, Ferrari LF, Levine J. Adenosine-A1 receptor agonist induced hyperalgesic priming type II. Pain. 2016 Mar; 157(3):698-709. PMID: 26588695.
      View in: PubMed
    64. Dubois SL, Wolfe A, Radovick S, Boehm U, Levine J. Estradiol Restrains Prepubertal Gonadotropin Secretion in Female Mice via Activation of ERa in Kisspeptin Neurons. Endocrinology. 2016 Apr; 157(4):1546-54. PMID: 26824364; PMCID: PMC4816723 [Available on 04/01/17].
    65. Cikla U, Chanana V, Kintner DB, Udho E, Eickhoff J, Sun W, Marquez S, Covert L, Otles A, Shapiro RA, Ferrazzano P, Vemuganti R, Levine J, Cengiz P. ERa Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy(1,2,3). eNeuro. 2016 Jan-Feb; 3(1). PMID: 26839918.
      View in: PubMed
    66. Conner LB, Alvarez P, Bogen O, Levine J. Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat. J Pain. 2016 Apr; 17(4):444-50. PMID: 26721612; PMCID: PMC4818681 [Available on 04/01/17].
    67. Smoot B, Cooper BA, Conley Y, Kober K, Levine J, Mastick J, Topp K, Miaskowski C. Differences in limb volume trajectories after breast cancer treatment. J Cancer Surviv. 2016 08; 10(4):772-82. PMID: 26678895; PMCID: PMC4912957 [Available on 08/01/17].
    68. Ferrari LF, Bogen O, Green P, Levine J. Contribution of Piezo2 to endothelium-dependent pain. Mol Pain. 2015 Oct 24; 11:65. PMID: 26497944; PMCID: PMC4619430.
    69. Kober KM, Cooper BA, Paul SM, Dunn LB, Levine J, Wright F, Hammer MJ, Mastick J, Venook A, Aouizerat BE, Miaskowski C. Subgroups of chemotherapy patients with distinct morning and evening fatigue trajectories. Support Care Cancer. 2016 Apr; 24(4):1473-85. PMID: 26361758.
      View in: PubMed
    70. Araldi D, Ferrari LF, Levine J. Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain. J Neurosci. 2015 Sep 09; 35(36):12502-17. PMID: 26354917; PMCID: PMC4563038.
    71. Gold M, Dunn LB, Phoenix B, Paul SM, Hamolsky D, Levine J, Miaskowski C. Co-occurrence of anxiety and depressive symptoms following breast cancer surgery and its impact on quality of life. Eur J Oncol Nurs. 2016 Feb; 20:97-105. PMID: 26187660.
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    72. Langford DJ, Paul SM, Cooper B, Kober KM, Mastick J, Melisko M, Levine J, Wright F, Hammer MJ, Cartwright F, Lee KA, Aouizerat BE, Miaskowski C. Comparison of subgroups of breast cancer patients on pain and co-occurring symptoms following chemotherapy. Support Care Cancer. 2016 Feb; 24(2):605-614. PMID: 26142303.
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    73. Green PG, Alvarez P, Levine J. Topical Tetrodotoxin Attenuates Photophobia Induced by Corneal Injury in the Rat. J Pain. 2015 Sep; 16(9):881-6. PMID: 26086898; PMCID: PMC4664153.
    74. Rissi DR, Levine J, Eden KB, Watson VE, Griffin JF, Edwards JF, Porter BF. Cerebral oligodendroglioma mimicking intraventricular neoplasia in three dogs. J Vet Diagn Invest. 2015 May; 27(3):396-400. PMID: 25943126.
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    75. Burakoff R, Pabby V, Onyewadume L, Odze R, Adackapara C, Wang W, Friedman S, Hamilton M, Korzenik J, Levine J, Makrauer F, Cheng C, Smith HC, Liew CC, Chao S. Blood-based biomarkers used to predict disease activity in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2015 May; 21(5):1132-40. PMID: 25895006.
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    76. Bogen O, Bender O, Löwe J, Blenau W, Thevis B, Schröder W, Margolis RU, Levine J, Hucho F. Neuronally produced versican V2 renders C-fiber nociceptors IB4 -positive. J Neurochem. 2015 Jul; 134(1):147-55. PMID: 25845936; PMCID: PMC4472531.
    77. Ferrari LF, Araldi D, Levine J. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci. 2015 Apr 15; 35(15):6107-16. PMID: 25878283; PMCID: PMC4397607.
    78. Wright F, D'Eramo Melkus G, Hammer M, Schmidt BL, Knobf MT, Paul SM, Cartwright F, Mastick J, Cooper BA, Chen LM, Melisko M, Levine J, Kober K, Aouizerat BE, Miaskowski C. Trajectories of Evening Fatigue in Oncology Outpatients Receiving Chemotherapy. J Pain Symptom Manage. 2015 Aug; 50(2):163-75. PMID: 25828560; PMCID: PMC4526403.
    79. Wright F, D'Eramo Melkus G, Hammer M, Schmidt BL, Knobf MT, Paul SM, Cartwright F, Mastick J, Cooper BA, Chen LM, Melisko M, Levine J, Kober K, Aouizerat BE, Miaskowski C. Predictors and Trajectories of Morning Fatigue Are Distinct From Evening Fatigue. J Pain Symptom Manage. 2015 Aug; 50(2):176-89. PMID: 25828559; PMCID: PMC4526314.
    80. Langford DJ, Paul SM, West CM, Dunn LB, Levine J, Kober KM, Dodd MJ, Miaskowski C, Aouizerat BE. Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery. Pain. 2015 Mar; 156(3):371-80. PMID: 25599232.
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    81. Alvarez P, Levine J, Green PG. Neonatal handling (resilience) attenuates water-avoidance stress induced enhancement of chronic mechanical hyperalgesia in the rat. Neurosci Lett. 2015 Mar 30; 591:207-11. PMID: 25637700; PMCID: PMC4711809.
    82. Ferrari LF, Bogen O, Reichling DB, Levine J. Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms. J Neurosci. 2015 Jan 14; 35(2):495-507. PMID: 25589745; PMCID: PMC4293406.
    83. Dubois SL, Acosta-Martínez M, DeJoseph MR, Wolfe A, Radovick S, Boehm U, Urban JH, Levine J. Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor a in kisspeptin neurons. Endocrinology. 2015 Mar; 156(3):1111-20. PMID: 25545386; PMCID: PMC4330313.
    84. Miaskowski C, Elboim C, Paul SM, Mastick J, Cooper BA, Levine J, Aouizerat BE. Polymorphisms in Tumor Necrosis Factor-a Are Associated With Higher Anxiety Levels in Women After Breast Cancer Surgery. Clin Breast Cancer. 2016 Feb; 16(1):63-71.e3. PMID: 25813148.
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    85. Bethea CL, Reddy AP, Flowers M, Shapiro RA, Colman RJ, Abbott DH, Levine J. High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 03; 58:71-80. PMID: 25542371; PMCID: PMC4339406.
    86. Langford DJ, Schmidt B, Levine J, Abrams G, Elboim C, Esserman L, Hamolsky D, Mastick J, Paul SM, Cooper B, Kober K, Dodd M, Dunn L, Aouizerat B, Miaskowski C. Preoperative Breast Pain Predicts Persistent Breast Pain and Disability After Breast Cancer Surgery. J Pain Symptom Manage. 2015 Jun; 49(6):981-94. PMID: 25527442; PMCID: PMC4470873.
    87. Langford DJ, Paul SM, West C, Abrams G, Elboim C, Levine J, Hamolsky D, Luce JA, Kober KM, Neuhaus JM, Cooper BA, Aouizerat BE, Miaskowski C. Persistent arm pain is distinct from persistent breast pain following breast cancer surgery. J Pain. 2014 Dec; 15(12):1238-47. PMID: 25439319.
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    88. Langford DJ, Paul SM, West C, Levine J, Hamolsky D, Elboim C, Schmidt BL, Cooper BA, Abrams G, Aouizerat BE, Miaskowski C. Persistent breast pain following breast cancer surgery is associated with persistent sensory changes, pain interference, and functional impairments. J Pain. 2014 Dec; 15(12):1227-37. PMID: 25439318.
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    89. Young BD, Mankin JM, Griffin JF, Fosgate GT, Fowler JL, Levine J. Comparison of two fat-suppressed magnetic resonance imaging pulse sequences to standard t2-weighted images for brain parenchymal contrast and lesion detection in dogs with inflammatory intracranial disease. Vet Radiol Ultrasound. 2015 Mar-Apr; 56(2):204-11. PMID: 25395066.
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    91. Alvarez P, Bogen O, Levine J. Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain. Pain. 2014 Dec; 155(12):2680-6. PMID: 25280432; PMCID: PMC4250399.
    92. Yelenik SG, Colman BP, Levine J, HilleRisLambers J. A mechanistic study of plant and microbial controls over R* for nitrogen in an annual grassland. PLoS One. 2014; 9(8):e106059. PMID: 25170943.
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    93. Rinz CJ, Levine J, Minor KM, Humphries HD, Lara R, Starr-Moss AN, Guo LT, Williams DC, Shelton GD, Clark LA. A COLQ missense mutation in Labrador Retrievers having congenital myasthenic syndrome. PLoS One. 2014; 9(8):e106425. PMID: 25166616; PMCID: PMC4148433.
    94. Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014 Jul 11; 3(4). PMID: 25015075; PMCID: PMC4310384.
    95. Taylor AR, Welsh CJ, Young C, Spoor E, Kerwin SC, Griffin JF, Levine GJ, Cohen ND, Levine J. Cerebrospinal fluid inflammatory cytokines and chemokines in naturally occurring canine spinal cord injury. J Neurotrauma. 2014 Sep 15; 31(18):1561-9. PMID: 24786364; PMCID: PMC4161168.
    96. Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine J, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst. 2014 Aug; 106(8). PMID: 24974128; PMCID: PMC4271080.
    97. Levine GJ, Cook JR, Kerwin SC, Mankin J, Griffin JF, Fosgate GT, Levine J. Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation. Vet Clin Pathol. 2014 Sep; 43(3):437-46. PMID: 24976308.
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    98. Smoot B, Paul SM, Aouizerat BE, Elboim C, Levine J, Abrams G, Hamolsky D, Neuhaus J, Schmidt B, West C, Topp K, Miaskowski C. Side of cancer does not influence limb volumes in women prior to breast cancer surgery. Lymphat Res Biol. 2014 Sep; 12(3):189-93. PMID: 24834791; PMCID: PMC4171111.
    99. Joseph EK, Green PG, Levine J. ATP release mechanisms of endothelial cell-mediated stimulus-dependent hyperalgesia. J Pain. 2014 Jul; 15(7):771-7. PMID: 24793242.
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    100. Levine J, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One. 2014; 9(5):e96408. PMID: 24788791; PMCID: PMC4006832.
    101. Chen X, Green PG, Levine J. Does the antihyperalgesic disruptor of endothelial cells, octoxynol-9, alter nociceptor function? J Neurophysiol. 2014 Jul 15; 112(2):463-6. PMID: 24790171; PMCID: PMC4064416.
    102. Godoy O, Kraft NJ, Levine J. Phylogenetic relatedness and the determinants of competitive outcomes. Ecol Lett. 2014 Jul; 17(7):836-44. PMID: 24766326.
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    103. Alvarez P, Levine J. Screening the role of pronociceptive molecules in a rodent model of endometriosis pain. J Pain. 2014 Jul; 15(7):726-33. PMID: 24755283; PMCID: PMC4119016.
    104. Slagelse C, Petersen KL, Dahl JB, Finnerup K, Greene K, Leong SP, Levine J, Rowbotham M, Werner MU, Finnerup NB. Persistent postoperative pain and sensory changes following lymph node excision in melanoma patients: a topical review. Melanoma Res. 2014 Apr; 24(2):93-8. PMID: 24346167.
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    105. Alvarez P, Green PG, Levine J. Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat. Pain. 2014 Jun; 155(6):1161-7. PMID: 24637038; PMCID: PMC4303347.
    106. Miaskowski C, Paul SM, Cooper B, West C, Levine J, Elboim C, Hamolsky D, Abrams G, Luce J, Dhruva A, Langford DJ, Merriman JD, Kober K, Baggott C, Leutwyler H, Aouizerat BE. Identification of patient subgroups and risk factors for persistent arm/shoulder pain following breast cancer surgery. Eur J Oncol Nurs. 2014 Jun; 18(3):242-53. PMID: 24485012.
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    107. Young BD, Fosgate GT, Holmes SP, Wolff CA, Chen-Allen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, Levine J. Evaluation of standard magnetic resonance characteristics used to differentiate neoplastic, inflammatory, and vascular brain lesions in dogs. Vet Radiol Ultrasound. 2014 Jul-Aug; 55(4):399-406. PMID: 24467341.
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    108. Ferrari LF, Bogen O, Levine J. Second messengers mediating the expression of neuroplasticity in a model of chronic pain in the rat. J Pain. 2014 Mar; 15(3):312-20. PMID: 24407022; PMCID: PMC3987850.
    109. Langford DJ, West C, Elboim C, Cooper BA, Abrams G, Paul SM, Schmidt BL, Levine J, Merriman JD, Dhruva A, Neuhaus J, Leutwyler H, Baggott C, Sullivan CW, Aouizerat BE, Miaskowski C. Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery. J Neurogenet. 2014 Mar-Jun; 28(1-2):122-35. PMID: 24392765; PMCID: PMC4035357.
    110. Reichling DB, Green PG, Levine J. The fundamental unit of pain is the cell. Pain. 2013 Dec; 154 Suppl 1. PMID: 24347805.
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    111. Stephens K, Cooper BA, West C, Paul SM, Baggott CR, Merriman JD, Dhruva A, Kober KM, Langford DJ, Leutwyler H, Luce JA, Schmidt BL, Abrams GM, Elboim C, Hamolsky D, Levine J, Miaskowski C, Aouizerat BE. Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery. J Pain. 2014 Feb; 15(2):169-80. PMID: 24411993.
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    112. Cooper JJ, Young BD, Griffin JF, Fosgate GT, Levine J. Comparison between noncontrast computed tomography and magnetic resonance imaging for detection and characterization of thoracolumbar myelopathy caused by intervertebral disk herniation in dogs. Vet Radiol Ultrasound. 2014 Mar-Apr; 55(2):182-9. PMID: 24118546.
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    113. Apkarian AV, Neugebauer V, Koob G, Edwards S, Levine J, Ferrari L, Egli M, Regunathan S. Neural mechanisms of pain and alcohol dependence. Pharmacol Biochem Behav. 2013 Nov; 112:34-41. PMID: 24095683; PMCID: PMC4887744.
    114. Andres C, Hasenauer J, Ahn HS, Joseph EK, Isensee J, Theis FJ, Allgöwer F, Levine J, Dib-Hajj SD, Waxman SG, Hucho T. Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia. Pain. 2013 Oct; 154(10):2216-26. PMID: 23867734.
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    115. Hendrich J, Alvarez P, Joseph EK, Chen X, Bogen O, Levine J. Electrophysiological correlates of hyperalgesic priming in vitro and in vivo. Pain. 2013 Oct; 154(10):2207-15. PMID: 23831864; PMCID: PMC3838101.
    116. Ferrari LF, Bogen O, Levine J. Role of nociceptor aCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats. J Neurosci. 2013 Jul 03; 33(27):11002-11. PMID: 23825405; PMCID: PMC3718370.
    117. Reichling DB, Green PG, Levine J. The fundamental unit of pain is the cell. Pain. 2013 Dec; 154 Suppl 1:S2-9. PMID: 23711480.
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    118. Alvarez P, Green PG, Levine J. Stress in the adult rat exacerbates muscle pain induced by early-life stress. Biol Psychiatry. 2013 Nov 01; 74(9):688-95. PMID: 23706525; PMCID: PMC3760993.
    119. Ferrari LF, Bogen O, Chu C, Levine J. Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat. J Pain. 2013 Jul; 14(7):731-8. PMID: 23664545; PMCID: PMC3700567.
    120. Lin Y, Chen Y, Wang Y, Yang J, Zhu VF, Liu Y, Cui X, Chen L, Yan W, Jiang T, Hergenroeder GW, Fletcher SA, Levine J, Kim DH, Tandon N, Zhu JJ, Li M. ZIP4 is a novel molecular marker for glioma. Neuro Oncol. 2013 Aug; 15(8):1008-16. PMID: 23595627; PMCID: PMC3714151.
    121. Taylor AR, Cohen ND, Fletcher S, Griffin JF, Levine J. Application and machine accuracy of a new frameless computed tomography-guided stereotactic brain biopsy system in dogs. Vet Radiol Ultrasound. 2013 Jul-Aug; 54(4):332-342. PMID: 23551960.
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    122. Joseph EK, Green PG, Bogen O, Alvarez P, Levine J. Vascular endothelial cells mediate mechanical stimulation-induced enhancement of endothelin hyperalgesia via activation of P2X2/3 receptors on nociceptors. J Neurosci. 2013 Feb 13; 33(7):2849-59. PMID: 23407944; PMCID: PMC3711399.
    123. Ferrari LF, Levine E, Levine J. Role of a novel nociceptor autocrine mechanism in chronic pain. Eur J Neurosci. 2013 May; 37(10):1705-13. PMID: 23379641.
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    124. Griffin JF, Cohen ND, Young BD, Eichelberger BM, Padua A, Purdy D, Levine J. Thoracic and lumbar spinal cord diffusion tensor imaging in dogs. J Magn Reson Imaging. 2013 Mar; 37(3):632-41. PMID: 23348907.
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    125. Gear R, Becerra L, Upadhyay J, Bishop J, Wallin D, Pendse G, Levine J, Borsook D. Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI. PLoS One. 2013; 8(1):e50169. PMID: 23341872; PMCID: PMC3540048.
    126. Miaskowski C, Cooper B, Paul SM, West C, Langford D, Levine J, Abrams G, Hamolsky D, Dunn L, Dodd M, Neuhaus J, Baggott C, Dhruva A, Schmidt B, Cataldo J, Merriman J, Aouizerat BE. Identification of patient subgroups and risk factors for persistent breast pain following breast cancer surgery. J Pain. 2012 Dec; 13(12):1172-87. PMID: 23182226.
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    127. Hendrich J, Alvarez P, Joseph EK, Ferrari LF, Chen X, Levine J. In vivo and in vitro comparison of female and male nociceptors. J Pain. 2012 Dec; 13(12):1224-31. PMID: 23146406; PMCID: PMC3508307.
    128. Hucho T, Suckow V, Joseph EK, Kuhn J, Schmoranzer J, Dina OA, Chen X, Karst M, Bernateck M, Levine J, Ropers HH. Ca++/CaMKII switches nociceptor-sensitizing stimuli into desensitizing stimuli. J Neurochem. 2012 Nov; 123(4):589-601. PMID: 22891703.
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    129. Alvarez P, Chen X, Bogen O, Green PG, Levine J. IB4(+) nociceptors mediate persistent muscle pain induced by GDNF. J Neurophysiol. 2012 Nov; 108(9):2545-53. PMID: 22914655; PMCID: PMC3545184.
    130. Stephens KE, Miaskowski CA, Levine J, Pullinger CR, Aouizerat BE. Epigenetic regulation and measurement of epigenetic changes. Biol Res Nurs. 2013 Oct; 15(4):373-81. PMID: 22661641.
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    131. McCann B, Miaskowski C, Koetters T, Baggott C, West C, Levine J, Elboim C, Abrams G, Hamolsky D, Dunn L, Rugo H, Dodd M, Paul SM, Neuhaus J, Cooper B, Schmidt B, Langford D, Cataldo J, Aouizerat BE. Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery. J Pain. 2012 May; 13(5):425-37. PMID: 22515947; PMCID: PMC3348353.
    132. Illi J, Miaskowski C, Cooper B, Levine J, Dunn L, West C, Dodd M, Dhruva A, Paul SM, Baggott C, Cataldo J, Langford D, Schmidt B, Aouizerat BE. Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression. Cytokine. 2012 Jun; 58(3):437-47. PMID: 22450224; PMCID: PMC3340525.
    133. Witsberger TH, Levine J, Fosgate GT, Slater MR, Kerwin SC, Russell KE, Levine GJ. Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation. J Am Vet Med Assoc. 2012 Mar 01; 240(5):555-62. PMID: 22332624.
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    134. Oaklander AL, Wilson PR, Moskovitz PA, Manning DC, Lubenow T, Levine J, Harden RN, Galer BS, Cooper MS, Bruehl S, Broatch J, Berde C, Bennett GJ. Response to "A new definition of neuropathic pain". Pain. 2012 Apr; 153(4):934-5; author reply 935-6. PMID: 22342073.
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    135. Bogen O, Alessandri-Haber N, Chu C, Gear RW, Levine J. Generation of a pain memory in the primary afferent nociceptor triggered by PKCe activation of CPEB. J Neurosci. 2012 Feb 08; 32(6):2018-26. PMID: 22323716; PMCID: PMC3305286.
    136. Fulkerson CV, Young BD, Jackson ND, Porter B, Levine J. MRI characteristics of cerebral microbleeds in four dogs. Vet Radiol Ultrasound. 2012 Jul-Aug; 53(4):389-93. PMID: 22235951.
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    137. Alvarez P, Gear RW, Green PG, Levine J. IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat. Exp Neurol. 2012 Feb; 233(2):859-65. PMID: 22206923; PMCID: PMC3272112.
    138. Joseph EK, Levine J. Sexual dimorphism in endothelin-1 induced mechanical hyperalgesia in the rat. Exp Neurol. 2012 Jan; 233(1):505-12. PMID: 22155617; PMCID: PMC3856663.
    139. Hettlich BF, Kerwin SC, Levine J. Early reherniation of disk material in eleven dogs with surgically treated thoracolumbar intervertebral disk extrusion. Vet Surg. 2012 Feb; 41(2):215-20. PMID: 22103469.
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    140. Vasseur DA, Amarasekare P, Rudolf VH, Levine J. Eco-Evolutionary dynamics enable coexistence via neighbor-dependent selection. Am Nat. 2011 Nov; 178(5):E96-E109. PMID: 22030739.
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    142. Ferrari LF, Chum A, Bogen O, Reichling DB, Levine J. Role of Drp1, a key mitochondrial fission protein, in neuropathic pain. J Neurosci. 2011 Aug 03; 31(31):11404-10. PMID: 21813700; PMCID: PMC3157245.
    143. Alvarez P, Ferrari LF, Levine J. Muscle pain in models of chemotherapy-induced and alcohol-induced peripheral neuropathy. Ann Neurol. 2011 Jul; 70(1):101-9. PMID: 21786301; PMCID: PMC3145965.
    144. Goswami C, Kuhn J, Dina OA, Fernández-Ballester G, Levine J, Ferrer-Montiel A, Hucho T. Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway. J Neurochem. 2011 Jun; 117(6):995-1008. PMID: 21480900.
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    145. Chu C, Levine E, Gear RW, Bogen O, Levine J. Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesia. Pain. 2011 Aug; 152(8):1832-7. PMID: 21570183; PMCID: PMC3161405.
    146. Chen X, Green PG, Levine J. Abnormal muscle afferent function in a model of Taxol chemotherapy-induced painful neuropathy. J Neurophysiol. 2011 Jul; 106(1):274-9. PMID: 21562188; PMCID: PMC3129739.
    147. Green PG, Alvarez P, Gear RW, Mendoza D, Levine J. Further validation of a model of fibromyalgia syndrome in the rat. J Pain. 2011 Jul; 12(7):811-8. PMID: 21481648; PMCID: PMC3130888.
    148. Gear RW, Levine J. Nucleus accumbens facilitates nociception. Exp Neurol. 2011 Jun; 229(2):502-6. PMID: 21458450; PMCID: PMC3100434.
    149. Levine J, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ. Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J Neurotrauma. 2011 Apr; 28(4):675-88. PMID: 21438715; PMCID: PMC3070145.
    150. Dina OA, Levine J, Green PG. Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress. Eur J Pain. 2011 Sep; 15(8):796-800. PMID: 21419675; PMCID: PMC3123688.
    151. Bolnick DI, Amarasekare P, Araújo MS, Bürger R, Levine J, Novak M, Rudolf VH, Schreiber SJ, Urban MC, Vasseur DA. Why intraspecific trait variation matters in community ecology. Trends Ecol Evol. 2011 Apr; 26(4):183-92. PMID: 21367482; PMCID: PMC3088364.
    152. Blair WH, Levine J, Kerwin SC, Spaulding KA, Young BD, Pool RR. Imaging diagnosis-synovial myxoma of lumbar vertebrae articular process joint. Vet Radiol Ultrasound. 2011 May-Jun; 52(3):309-12. PMID: 21554479.
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    153. Reichling DB, Levine J. Pain and death: neurodegenerative disease mechanisms in the nociceptor. Ann Neurol. 2011 Jan; 69(1):13-21. PMID: 21280072.
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    154. Andres C, Meyer S, Dina OA, Levine J, Hucho T. Quantitative automated microscopy (QuAM) elucidates growth factor specific signalling in pain sensitization. Mol Pain. 2010 Dec 27; 6:98. PMID: 21187008; PMCID: PMC3023724.
    155. Cooper JJ, Young BD, Hoffman A, Bratton G, Hicks DG, Tidwell A, Levine J. Intracranial magnetic resonance imaging artifacts and pseudolesions in dogs and cats. Vet Radiol Ultrasound. 2010 Nov-Dec; 51(6):587-95. PMID: 21158228.
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    156. Ferrari LF, Gear RW, Levine J. Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat. J Neurosci. 2010 Oct 13; 30(41):13699-706. PMID: 20943910; PMCID: PMC2970511.
    157. Levine J, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credille BC, Tennent-Brown B, Cohen ND. Multicenter case-control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation-malarticulation in horses. J Am Vet Med Assoc. 2010 Oct 01; 237(7):812-22. PMID: 20919847.
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    158. Chen X, Green PG, Levine J. Neuropathic pain-like alterations in muscle nociceptor function associated with vibration-induced muscle pain. Pain. 2010 Nov; 151(2):460-6. PMID: 20800357; PMCID: PMC2932645.
    159. Ferrari LF, Levine J. Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms. Eur J Neurosci. 2010 Sep; 32(5):811-8. PMID: 20726883; PMCID: PMC2974761.
    160. Alvarez P, Levine J, Green PG. Eccentric exercise induces chronic alterations in musculoskeletal nociception in the rat. Eur J Neurosci. 2010 Sep; 32(5):819-25. PMID: 20726881; PMCID: PMC2974795.
    161. Hettlich BF, Fosgate GT, Levine J, Young BD, Kerwin SC, Walker M, Griffin J, Maierl J. Accuracy of conventional radiography and computed tomography in predicting implant position in relation to the vertebral canal in dogs. Vet Surg. 2010 Aug; 39(6):680-7. PMID: 20459486.
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    162. Joseph EK, Levine J. Multiple PKCe-dependent mechanisms mediating mechanical hyperalgesia. Pain. 2010 Jul; 150(1):17-21. PMID: 20456866; PMCID: PMC2916056.
    163. Joseph EK, Reichling DB, Levine J. Shared mechanisms for opioid tolerance and a transition to chronic pain. J Neurosci. 2010 Mar 31; 30(13):4660-6. PMID: 20357116; PMCID: PMC2857996.
    164. Dewey CW, Cerda-Gonzalez S, Fletcher DJ, Harb-Hauser MF, Levine J, Badgley BL, Olby NJ, Shelton GD. Mycophenolate mofetil treatment in dogs with serologically diagnosed acquired myasthenia gravis: 27 cases (1999-2008). J Am Vet Med Assoc. 2010 Mar 15; 236(6):664-8. PMID: 20225980.
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    165. Snyder K, Saunders AB, Levine J, Clubb FJ. Arrhythmias and elevated troponin I in a dog with steroid-responsive meningitis-arteritis. J Am Anim Hosp Assoc. 2010 Jan-Feb; 46(1):61-5. PMID: 20045839.
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    166. Cooper JJ, Levine J, Young BD, Hicks DG, Hoffman A, Bratton G. Imaging diagnosis--magnetic resonance imaging pseudolesion associated with the petrous temporal bone. Vet Radiol Ultrasound. 2010 Jan-Feb; 51(1):39-41. PMID: 20166391.
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    167. Dewey CW, Cerda-Gonzalez S, Levine J, Badgley BL, Ducoté JM, Silver GM, Cooper JJ, Packer RA, Lavely JA. Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy. J Am Vet Med Assoc. 2009 Dec 15; 235(12):1442-9. PMID: 20001779.
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    168. Dina OA, Joseph EK, Levine J, Green PG. Mechanisms mediating vibration-induced chronic musculoskeletal pain analyzed in the rat. J Pain. 2010 Apr; 11(4):369-77. PMID: 19962353; PMCID: PMC2847637.
    169. Reichling DB, Levine J. Critical role of nociceptor plasticity in chronic pain. Trends Neurosci. 2009 Dec; 32(12):611-8. PMID: 19781793; PMCID: PMC2787756.
    170. Gear RW, Levine J. Rostral ventral medulla cholinergic mechanism in pain-induced analgesia. Neurosci Lett. 2009 Oct 30; 464(3):170-2. PMID: 19699268; PMCID: PMC2756415.
    171. Gottsch ML, Navarro VM, Zhao Z, Glidewell-Kenney C, Weiss J, Jameson JL, Clifton DK, Levine J, Steiner RA. Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci. 2009 Jul 22; 29(29):9390-5. PMID: 19625529; PMCID: PMC2819182.
    172. Khasar SG, Dina OA, Green PG, Levine J. Sound stress-induced long-term enhancement of mechanical hyperalgesia in rats is maintained by sympathoadrenal catecholamines. J Pain. 2009 Oct; 10(10):1073-7. PMID: 19576859; PMCID: PMC2757466.
    173. Alessandri-Haber N, Dina OA, Chen X, Levine J. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009 May 13; 29(19):6217-28. PMID: 19439599; PMCID: PMC2726836.
    174. Israel SK, Levine J, Kerwin SC, Levine GJ, Fosgate GT. The relative sensitivity of computed tomography and myelography for identification of thoracolumbar intervertebral disk herniations in dogs. Vet Radiol Ultrasound. 2009 May-Jun; 50(3):247-52. PMID: 19507385.
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    175. Tambeli CH, Levine J, Gear RW. Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord. Pain. 2009 Jun; 143(3):228-32. PMID: 19375225; PMCID: PMC2693265.
    176. Levine GJ, Levine J, Budke CM, Kerwin SC, Au J, Vinayak A, Hettlich BF, Slater MR. Description and repeatability of a newly developed spinal cord injury scale for dogs. Prev Vet Med. 2009 May 01; 89(1-2):121-7. PMID: 19303151.
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    177. Griffin JF, Young BD, Levine J. Imaging diagnosis--chronic canine distemper meningoencephalitis. Vet Radiol Ultrasound. 2009 Mar-Apr; 50(2):182-4. PMID: 19400465.
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    178. Joseph EK, Levine J. Comparison of oxaliplatin- and cisplatin-induced painful peripheral neuropathy in the rat. J Pain. 2009 May; 10(5):534-41. PMID: 19231296; PMCID: PMC2741410.
    179. Levine J, Ngheim PP, Levine GJ, Cohen ND. Associations of sex, breed, and age with cervical vertebral compressive myelopathy in horses: 811 cases (1974-2007). J Am Vet Med Assoc. 2008 Nov 01; 233(9):1453-8. PMID: 18980501.
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    180. Brown AS, Levine J, Green PG. Sexual dimorphism in the effect of sound stress on neutrophil function. J Neuroimmunol. 2008 Dec 15; 205(1-2):25-31. PMID: 18838177.
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    181. McDevitt MA, Thorsness RJ, Levine J. A role for ATP-sensitive potassium channels in male sexual behavior. Horm Behav. 2009 Feb; 55(2):366-74. PMID: 18950632.
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    182. Levine J, Budke CM, Levine GJ, Kerwin SC, Hettlich BF, Slater MR. Owner-perceived, weighted quality-of-life assessments in dogs with spinal cord injuries. J Am Vet Med Assoc. 2008 Sep 15; 233(6):931-5. PMID: 18795855.
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    183. Budke CM, Levine J, Kerwin SC, Levine GJ, Hettlich BF, Slater MR. Evaluation of a questionnaire for obtaining owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries. J Am Vet Med Assoc. 2008 Sep 15; 233(6):925-30. PMID: 18795853.
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    184. Dina OA, Khasar SG, Alessandri-Haber N, Bogen O, Chen X, Green PG, Reichling DB, Messing RO, Levine J. Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy. Eur J Neurosci. 2008 Sep; 28(6):1180-90. PMID: 18783367; PMCID: PMC2746092.
    185. Bogen O, Joseph EK, Chen X, Levine J. GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci. 2008 Jul; 28(1):12-9. PMID: 18616564; PMCID: PMC2660608.
    186. Baltzer WI, McMichael MA, Hosgood GL, Kerwin SC, Levine J, Steiner JM, Ruaux CG. Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. Spine (Phila Pa 1976). 2008 Jun 01; 33(13):1397-402. PMID: 18520934.
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    187. Khasar SG, Burkham J, Dina OA, Brown AS, Bogen O, Alessandri-Haber N, Green PG, Reichling DB, Levine J. Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain. J Neurosci. 2008 May 28; 28(22):5721-30. PMID: 18509033; PMCID: PMC2518401.
    188. Kuhn J, Dina OA, Goswami C, Suckow V, Levine J, Hucho T. GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat. Eur J Neurosci. 2008 Apr; 27(7):1700-9. PMID: 18371086.
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    189. Joseph EK, Chen X, Bogen O, Levine J. Oxaliplatin acts on IB4-positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy. J Pain. 2008 May; 9(5):463-72. PMID: 18359667.
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    190. Dina OA, Levine J, Green PG. Muscle inflammation induces a protein kinase Cepsilon-dependent chronic-latent muscle pain. J Pain. 2008 May; 9(5):457-62. PMID: 18342576; PMCID: PMC2424185.
    191. Sughrue ME, Levine J, Barbaro NM. Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions. J Brachial Plex Peripher Nerve Inj. 2008 Feb 29; 3:6. PMID: 18312658; PMCID: PMC2291052.
    192. Huang W, Acosta-Martínez M, Levine J. Ovarian steroids stimulate adenosine triphosphate-sensitive potassium (KATP) channel subunit gene expression and confer responsiveness of the gonadotropin-releasing hormone pulse generator to KATP channel modulation. Endocrinology. 2008 May; 149(5):2423-32. PMID: 18258681; PMCID: PMC2329280.
    193. Levine J, Levine GJ, Boozer L, Schatzberg SJ, Platt SR, Kent M, Kerwin SC, Fosgate GT. Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006). J Am Vet Med Assoc. 2008 Feb 01; 232(3):411-7. PMID: 18241109.
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    194. Alessandri-Haber N, Dina OA, Joseph EK, Reichling DB, Levine J. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J Neurosci. 2008 Jan 30; 28(5):1046-57. PMID: 18234883.
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    195. Gear RW, Gordon NC, Hossaini-Zadeh M, Lee JS, Miaskowski C, Paul SM, Levine J. A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain. J Pain. 2008 Apr; 9(4):337-41. PMID: 18201935; PMCID: PMC2364600.
    196. Dina OA, Khasar SG, Alessandri-Haber N, Green PG, Messing RO, Levine J. Alcohol-induced stress in painful alcoholic neuropathy. Eur J Neurosci. 2008 Jan; 27(1):83-92. PMID: 18093169.
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    197. Chen X, Alessandri-Haber N, Levine J. Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice. Mol Pain. 2007 Oct 29; 3:31. PMID: 17967183; PMCID: PMC2173885.
    198. Zhang C, Bosch MA, Levine J, Rønnekleiv OK, Kelly MJ. Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J Neurosci. 2007 Sep 19; 27(38):10153-64. PMID: 17881521.
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    199. Gordon AT, Levine J, Dubois MY, D'Angelo R, Conlon AM, Levacic D, Lebovits A. Open-label exploration of an intravenous nalbuphine and naloxone mixture as an analgesic agent following gynecologic surgery. Pain Med. 2007 Sep; 8(6):525-30. PMID: 17716327.
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    200. Summer GJ, Dina OA, Levine J. Enhanced inflammatory hyperalgesia after recovery from burn injury. Burns. 2007 Dec; 33(8):1021-6. PMID: 17707592.
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    201. McDevitt MA, Glidewell-Kenney C, Weiss J, Chambon P, Jameson JL, Levine J. Estrogen response element-independent estrogen receptor (ER)-alpha signaling does not rescue sexual behavior but restores normal testosterone secretion in male ERalpha knockout mice. Endocrinology. 2007 Nov; 148(11):5288-94. PMID: 17673514.
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    202. Hucho T, Levine J. Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron. 2007 Aug 02; 55(3):365-76. PMID: 17678851.
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    203. Levine J, Adam E, MacKay RJ, Walker MA, Frederick JD, Cohen ND. Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992-2004). J Vet Intern Med. 2007 Jul-Aug; 21(4):812-9. PMID: 17708404.
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    204. Levine J, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT. Evaluation of the success of medical management for presumptive cervical intervertebral disk herniation in dogs. Vet Surg. 2007 Jul; 36(5):492-9. PMID: 17614931.
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    205. Levine J, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT. Evaluation of the success of medical management for presumptive thoracolumbar intervertebral disk herniation in dogs. Vet Surg. 2007 Jul; 36(5):482-91. PMID: 17614930.
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    206. Summer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine J. Proinflammatory cytokines mediating burn-injury pain. Pain. 2008 Mar; 135(1-2):98-107. PMID: 17590515.
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    207. de Coupade C, Brown AS, Dazin PF, Levine J, Green PG. beta(2)-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration. J Neuroimmunol. 2007 May; 186(1-2):54-62. PMID: 17442405; PMCID: PMC1994158.
    208. Summer GJ, Puntillo KA, Miaskowski C, Green PG, Levine J. Burn injury pain: the continuing challenge. J Pain. 2007 Jul; 8(7):533-48. PMID: 17434800.
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    209. Joseph EK, Bogen O, Alessandri-Haber N, Levine J. PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia. Pain. 2007 Nov; 132(1-2):67-73. PMID: 17350763.
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    210. Chen X, Levine J. Mechanically-evoked C-fiber activity in painful alcohol and AIDS therapy neuropathy in the rat. Mol Pain. 2007 Feb 23; 3:5. PMID: 17319957; PMCID: PMC1819368.
    211. Levine J, Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim Biophys Acta. 2007 Aug; 1772(8):989-1003. PMID: 17321113.
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    212. Summer GJ, Puntillo KA, Miaskowski C, Dina OA, Green PG, Levine J. TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat. J Pain. 2006 Dec; 7(12):884-91. PMID: 17157774.
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    213. Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine J, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol. 2007 Feb 01; 578(Pt 3):715-33. PMID: 17124270; PMCID: PMC2151332.
    214. Levine GJ, Bissett WT, Cole RC, Janke JJ, Nunes J, Porter B, Levine J. Imaging diagnosis--bacterial diskospondylitis in a goat. Vet Radiol Ultrasound. 2006 Oct-Nov; 47(6):585-8. PMID: 17153069.
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    215. Paredes J, Szeto A, Levine J, Zaias J, Gonzales JA, Mendez AJ, Llabre MM, Schneiderman N, McCabe PM. Social experience influences hypothalamic oxytocin in the WHHL rabbit. Psychoneuroendocrinology. 2006 Oct; 31(9):1062-75. PMID: 16963189.
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    216. McCarter GC, Levine J. Ionic basis of a mechanotransduction current in adult rat dorsal root ganglion neurons. Mol Pain. 2006 Aug 21; 2:28. PMID: 16923187; PMCID: PMC1563451.
    217. Levine J, Levine GJ, Kerwin SC, Hettlich BF, Fosgate GT. Association between various physical factors and acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds. J Am Vet Med Assoc. 2006 Aug 01; 229(3):370-5. PMID: 16881827.
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    218. Hucho TB, Dina OA, Kuhn J, Levine J. Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons. Eur J Neurosci. 2006 Jul; 24(2):527-34. PMID: 16836642.
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    219. Dina OA, Messing RO, Levine J. Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon. Eur J Neurosci. 2006 Jul; 24(1):197-204. PMID: 16800864.
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    220. Levine J, Khasar SG, Green PG. Neurogenic inflammation and arthritis. Ann N Y Acad Sci. 2006 Jun; 1069:155-67. PMID: 16855143.
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    221. Alessandri-Haber N, Dina OA, Joseph EK, Reichling D, Levine J. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci. 2006 Apr 05; 26(14):3864-74. PMID: 16597741.
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    222. Gear RW, Lee JS, Miaskowski C, Gordon NC, Paul SM, Levine J. Neuroleptics antagonize nalbuphine antianalgesia. J Pain. 2006 Mar; 7(3):187-91. PMID: 16516824.
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    223. Joseph EK, Levine J. Mitochondrial electron transport in models of neuropathic and inflammatory pain. Pain. 2006 Mar; 121(1-2):105-14. PMID: 16472913.
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    224. Levine J, Ruaux CG, Bergman RL, Coates JR, Steiner JM, Williams DA. Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease. Am J Vet Res. 2006 Feb; 67(2):283-7. PMID: 16454634.
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    225. Levine GJ, Levine J, Walker MA, Pool RR, Fosgate GT. Evaluation of the association between spondylosis deformans and clinical signs of intervertebral disk disease in dogs: 172 cases (1999-2000). J Am Vet Med Assoc. 2006 Jan 01; 228(1):96-100. PMID: 16426177.
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    226. Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine J. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain. 2005 Nov; 118(1-2):70-9. PMID: 16213085.
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    227. Foecking EM, Levine J. Effects of experimental hyperandrogenemia on the female rat reproductive axis: suppression of progesterone-receptor messenger RNA expression in the brain and blockade of luteinizing hormone surges. Gend Med. 2005 Sep; 2(3):155-65. PMID: 16290888.
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    228. Levine J, Reichling DB. Fibromyalgia: the nerve of that disease. J Rheumatol Suppl. 2005 Aug; 75:29-37. PMID: 16078358.
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    229. Barker LA, Dazin PF, Levine J, Green PG. Sympathoadrenal-dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat. Br J Pharmacol. 2005 Aug; 145(7):872-9. PMID: 15912135; PMCID: PMC1576213.
    230. Khasar SG, Green PG, Levine J. Repeated sound stress enhances inflammatory pain in the rat. Pain. 2005 Jul; 116(1-2):79-86. PMID: 15936144.
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    231. Chen X, Levine J. Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors. J Pain. 2005 Jul; 6(7):439-46. PMID: 15993822.
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    232. Hucho TB, Dina OA, Levine J. Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci. 2005 Jun 29; 25(26):6119-26. PMID: 15987941.
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    233. Malik-Hall M, Dina OA, Levine J. Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia. Eur J Neurosci. 2005 Jun; 21(12):3387-94. PMID: 16026476.
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    234. Khasar SG, Dina OA, Green PG, Levine J. Estrogen regulates adrenal medullary function producing sexual dimorphism in nociceptive threshold and beta-adrenergic receptor-mediated hyperalgesia in the rat. Eur J Neurosci. 2005 Jun; 21(12):3379-86. PMID: 16026475.
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    235. Dina OA, Hucho T, Yeh J, Malik-Hall M, Reichling DB, Levine J. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Pain. 2005 May; 115(1-2):191-203. PMID: 15836982.
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    236. Foecking EM, Szabo M, Schwartz NB, Levine J. Neuroendocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator. Biol Reprod. 2005 Jun; 72(6):1475-83. PMID: 15744016.
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    237. Green PG, Levine J. Sexual dimorphism in the effect of nonhabituating stress on neurogenic plasma extravasation. Eur J Neurosci. 2005 Jan; 21(2):486-92. PMID: 15673447.
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    238. Joseph EK, Levine J. Caspase signalling in neuropathic and inflammatory pain in the rat. Eur J Neurosci. 2004 Dec; 20(11):2896-902. PMID: 15579143.
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    239. Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine J, Schumacher MA. Isolation of an mRNA binding protein homologue that is expressed in nociceptors. Eur J Neurosci. 2004 Nov; 20(9):2283-93. PMID: 15525270.
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    240. de Coupade C, Gear RW, Dazin PF, Sroussi HY, Green PG, Levine J. Beta 2-adrenergic receptor regulation of human neutrophil function is sexually dimorphic. Br J Pharmacol. 2004 Dec; 143(8):1033-41. PMID: 15477226; PMCID: PMC1575953.
    241. Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, Levine J. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci. 2004 May 05; 24(18):4444-52. PMID: 15128858.
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    242. Dina OA, Parada CA, Yeh J, Chen X, McCarter GC, Levine J. Integrin signaling in inflammatory and neuropathic pain in the rat. Eur J Neurosci. 2004 Feb; 19(3):634-42. PMID: 14984413.
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    243. Hill JW, Urban JH, Xu M, Levine J. Estrogen Induces Neuropeptide Y (NPY) Y1 receptor gene expression and responsiveness to NPY in gonadotrope-enriched pituitary cell cultures. Endocrinology. 2004 May; 145(5):2283-90. PMID: 14726443.
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    244. Miao FJ, Green PG, Levine J. Mechanosensitive duodenal afferents contribute to vagal modulation of inflammation in the rat. J Physiol. 2004 Jan 01; 554(Pt 1):227-35. PMID: 14678504; PMCID: PMC1664747.
    245. Joseph EK, Chen X, Khasar SG, Levine J. Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. Pain. 2004 Jan; 107(1-2):147-58. PMID: 14715401.
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    246. Gear RW, Gordon NC, Miaskowski C, Paul SM, Heller PH, Levine J. Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans. Neurosci Lett. 2003 Nov 06; 351(1):5-8. PMID: 14550900.
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    247. Tambeli CH, Young A, Levine J, Gear RW. Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation. Pain. 2003 Nov; 106(1-2):173-9. PMID: 14581125.
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    248. Miao FJ, Green P, Benowitz N, Levine J. Vagal modulation of spinal nicotine-induced inhibition of the inflammatory response mediated by descending antinociceptive controls. Neuropharmacology. 2003 Oct; 45(5):605-11. PMID: 12941374.
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    249. Joseph EK, Parada CA, Levine J. Hyperalgesic priming in the rat demonstrates marked sexual dimorphism. Pain. 2003 Sep; 105(1-2):143-50. PMID: 14499430.
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    250. Dina OA, McCarter GC, de Coupade C, Levine J. Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain. Neuron. 2003 Aug 14; 39(4):613-24. PMID: 12925276.
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    251. de Coupade C, Solito E, Levine J. Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937. Br J Pharmacol. 2003 Sep; 140(1):133-45. PMID: 12967943; PMCID: PMC1574011.
    252. Alessandri-Haber N, Yeh JJ, Boyd AE, Parada CA, Chen X, Reichling DB, Levine J. Hypotonicity induces TRPV4-mediated nociception in rat. Neuron. 2003 Jul 31; 39(3):497-511. PMID: 12895423.
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    253. Khasar SG, Gear RW, Levine J. Absence of nalbuphine anti-analgesia in the rat. Neurosci Lett. 2003 Jul 24; 345(3):165-8. PMID: 12842282.
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    254. Schmidt BL, Gear RW, Levine J. Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humans. Neurosci Lett. 2003 Jun 05; 343(2):144-6. PMID: 12759184.
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    255. Khasar SG, Miao FJ, Gear RW, Green PG, Levine J. Vagal modulation of bradykinin-induced mechanical hyperalgesia in the female rat. J Pain. 2003 Jun; 4(5):278-83. PMID: 14622697.
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    256. Parada CA, Yeh JJ, Joseph EK, Levine J. Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur J Neurosci. 2003 May; 17(9):1847-52. PMID: 12752784.
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    257. Khasar SG, Green PG, Gear RW, Isenberg W, Levine J. Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat. J Pain. 2003 May; 4(4):190-6. PMID: 14622703.
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    258. Schmidt BL, Tambeli CH, Levine J, Gear RW. Adaptations in nucleus accumbens circuitry during opioid withdrawal associated with persistence of noxious stimulus-induced antinociception in the rat. J Pain. 2003 Apr; 4(3):141-7. PMID: 14622711.
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    259. Gear RW, Gordon NC, Miaskowski C, Paul SM, Heller PH, Levine J. Sexual dimorphism in very low dose nalbuphine postoperative analgesia. Neurosci Lett. 2003 Mar 13; 339(1):1-4. PMID: 12618286.
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    260. Strausbaugh HJ, Green PG, Dallman MF, Levine J. Repeated, non-habituating stress suppresses inflammatory plasma extravasation by a novel, sympathoadrenal dependent mechanism. Eur J Neurosci. 2003 Feb; 17(4):805-12. PMID: 12603270.
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    261. Khasar SG, Green PG, Miao FJ, Levine J. Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat. Eur J Neurosci. 2003 Feb; 17(4):909-15. PMID: 12603283.
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    262. Harris GC, Levine J. Pubertal acceleration of pulsatile gonadotropin-releasing hormone release in male rats as revealed by microdialysis. Endocrinology. 2003 Jan; 144(1):163-71. PMID: 12488342.
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    263. Aley O, Levine J. Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat. Exp Brain Res. 2003 Feb; 148(4):482-7. PMID: 12582831.
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    264. Tambeli CH, Parada CA, Levine J, Gear RW. Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat. Eur J Neurosci. 2002 Oct; 16(8):1547-53. PMID: 12405969.
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    265. Levine J, Rees M. Coexistence and relative abundance in annual plant assemblages: the roles of competition and colonization. Am Nat. 2002 Oct; 160(4):452-67. PMID: 18707522.
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    266. Khasar SG, Miao FJ, Gear RW, Green PG, Isenberg WM, Levine J. Sympathetic-independent bradykinin mechanical hyperalgesia induced by subdiaphragmatic vagotomy in the rat. J Pain. 2002 Oct; 3(5):369-76. PMID: 14622740.
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    267. Schmidt BL, Tambeli CH, Barletta J, Luo L, Green P, Levine J, Gear RW. Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats. J Neurosci. 2002 Aug 01; 22(15):6773-80. PMID: 12151557.
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