Deanna Kroetz, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-476-1159
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    Collapse Biography 
    Collapse Education and Training
    Ohio State University, Columbus, OHBS06/1985Pharmacy
    University of Washington, Seattle, WAPhD08/1990Pharmaceutics
    National Cancer Institute, Bethesda, MS06/1993Drug Metabolism
    Collapse Awards and Honors
    National Pharmaceutical Council 1984  - 1984National Pharmaceutical Council Internship Mortar Board Honor Society Rho Chi National Pharmacy Ho
    Cum Laude Graduate Ohio State University College of Pharmacy1985  - 1985Ohio State University Presidential Scholar Eli Lilly Company Achievement Award
    National Institute of Health Training1987  - 1990National Institute of Health Training Grant Trainee
    Pharmacology Research Associate Training1991  - 1993Pharmacology Research Associate Training (PRAT) Fellowship
    Ohio State University College of Pharmacy1995  - 1995Josephine S. Failer Alumni Award
    American Association of Pharmaceutical Scientists 1996  - 1996American Association of Pharmaceutical Scientists Young Investigator Award in Pharmacokinetics, Phar
    American Society for Clinical Pharmacology and Therapeutics2002  - 2002Leon I. Goldberg Young Investigator Award
    American Heart Association2002  - 2002Elected Fellow, High Blood Pressure Research Council of the American Heart Association
    American Association of Pharmaceutical Scientists2008  - 2008Elected Fellow, American Association of Pharmaceutical Scientists
    Pharmacology2008  - 2008Named to Faculty of 1000, Pharmacology
    UCSF School of Pharmacy 2009  - 2009Deans Apple Award for Teaching
    UCSF School of Pharmacy 2011  - 2011Deans Apple Award for Teaching
    Northern California Association for Women in Science 2014  - 2014Judith Pool Award for Mentoring
    UCSF School of Pharmacy2016  - 2016Deans Apple Award for Teaching
    UCSF School of Pharmacy2018  - 2018Deans Apple Award for Teaching
    American Association for the Advancement of Science2018  - 2018Elected Fellow
    University of Washington School of Pharmacy 2018  - 2018Distinguished Alumnus Award for Excellence in Pharmaceutical Sciences and Research
    UCSF School of Pharmacy2019  - 2019Deans Apple Award for Teaching
    American Society for Clinical Pharmacology and Therapeutics 2019  - 2019Mentor Award
    American College of Clinical Pharmacology2020  - 2020Bristol-Myers Squibb Mentorship in Clinical Pharmacology Award
    Advancement of Pharmacy2020  - 2020Jere E. Goyan Presidential Chair
    UCSF School of Pharmacy2020  - 2020Deans Apple Award for Teaching

    Collapse Overview 
    Collapse Overview
    The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
    NIH R01CA261068Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Targeting MRP4-Mediated PGE2 Efflux to Improve Sensitivity to Immunotherapy
    The Cancer League Cancer CenterJun 1, 2020 - May 31, 2021
    Role: Principal Investigator
    Role Description: The goal of these pilot studies is to demonstrate that inhibition of MRP4-mediated efflux of PGE2 from tumor cells improves the response to immunotherapy.
    The Role of Genomics in Postoperative Delirium and Sedation
    NIH/NINR R01 NR017622Oct 1, 2019 - Sep 30, 2022
    Role: Co-investigator leading the genomic analyses
    Role Description: The goal of these studies is to identify genomic predictors of delirium and sedation in response to opiates following surgery in elderly patients. A predictive model will be developed to identify at risk patients prior to surgery and to modify opiate treatment to reduce risk of cognitive decline.
    Individualized Therapy for Recurrent Glioblastoma
    Private FoundationApr 1, 2018 - Mar 31, 2021
    Role: Co-investigator for pharmacology
    Role Description: The goal of these pilot studies is to use tumor sequencing to individualize therapy for patients with receurrent glioblastoma. The main outcome of this pilot study is the feasibility of exome sequencing for personalized therapy.
    Developing Silastic-Silicone for the Local Delivery of Hormonal Therapy to Prevent and Treat Breast Cancer
    NIH/NCI R01 CA220131Jul 1, 2017 - Jun 30, 2022
    Role: Co-Investigator
    Role Description: To develop a novel drug delivery tool to deliver high concentrations of approved and effective anti-estrogen directly to the breast parenchyma with minimal systemic exposure.
    Pharmacogenomics of Microtubule Targeting Agents
    NIH R01 CA192156-01A1Jul 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Role Description: The major goal of this study is to identify genetic predictors of microtubule targeting agent induced sensory peripheral neuropathy. Exome sequencing of samples from CALGB 40502 will be coupled with functional genomics studies to understand the molecular basis of this dose-limiting toxicity for paclitaxel and other microtubule targeting agents.
    Pharmaceutical Sciences and Pharmacogenomics
    NIH/NIGMS T32 GM007175-41Jul 1, 1982 - Jun 30, 2022
    Role: Principal Investigator
    Role Description: The goal of the PSPG graduate program is to educate and train Ph.D. students to conceptualize, design and execute innovative scientific research in the interdisciplinary scientific areas encompassed by modern pharmaceutical sciences.

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Student Projects
    Collapse Academic Senate

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel. Clin Transl Sci. 2021 03; 14(2):568-581. Xiong C, Chua KC, Stage TB, Priotti J, Kim J, Altman-Merino A, Chan D, Saraf K, Canato Ferracini A, Fattahi F, Kroetz DL. PMID: 33340242.
      View in: PubMed   Mentions:    Fields:    
    2. GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer. Clin Transl Sci. 2021 03; 14(2):720-728. Ferracini AC, Lopes-Aguiar L, Lourenço GJ, Yoshida A, Lima CSP, Sarian LO, Derchain S, Kroetz DL, Mazzola PG. PMID: 33326171.
      View in: PubMed   Mentions:    Fields:    
    3. Role for Drug Transporters in Chemotherapy-Induced Peripheral Neuropathy. Clin Transl Sci. 2021 03; 14(2):460-467. Stage TB, Hu S, Sparreboom A, Kroetz DL. PMID: 33142018.
      View in: PubMed   Mentions: 2     Fields:    
    4. Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy. Clin Pharmacol Ther. 2020 09; 108(3):625-634. Chua KC, Xiong C, Ho C, Mushiroda T, Jiang C, Mulkey F, Lai D, Schneider BP, Rashkin SR, Witte JS, Friedman PN, Ratain MJ, McLeod HL, Rugo HS, Shulman LN, Kubo M, Owzar K, Kroetz DL. PMID: 32562552.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer. Clin Pharmacol Ther. 2020 09; 108(3):671-680. Stage TB, Mortensen C, Khalaf S, Steffensen V, Hammer HS, Xiong C, Nielsen F, Poetz O, Svenningsen ÅF, Rodriguez-Antona C, Kroetz DL. PMID: 32275773.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Reversible inhibition of efflux transporters by hydrogel microdevices. Eur J Pharm Biopharm. 2019 Dec; 145:76-84. Levy ES, Samy KE, Lamson NG, Whitehead KA, Kroetz DL, Desai TA. PMID: 31639417.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Efficient estimation of grouped survival models. BMC Bioinformatics. 2019 May 28; 20(1):269. Li Z, Lin J, Sibley AB, Truong T, Chua KC, Jiang Y, McCarthy J, Kroetz DL, Allen A, Owzar K. PMID: 31138120.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clin Transl Sci. 2019 07; 12(4):388-399. Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM. PMID: 30982223.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing. J Pharmacol Exp Ther. 2019 06; 369(3):523-530. Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S. PMID: 30910922.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service. J Am Coll Clin Pharm. 2019 Jun; 2(3):214-221. Zakinova A, Long-Boyle JR, French D, Croci R, Wilson L, Phillips KA, Kroetz DL, Shin J, Tamraz B. PMID: 32391517.
      View in: PubMed   Mentions:
    11. A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance). Clin Pharmacol Ther. 2019 03; 105(3):738-745. Rashkin SR, Chua KC, Ho C, Mulkey F, Jiang C, Mushiroda T, Kubo M, Friedman PN, Rugo HS, McLeod HL, Ratain MJ, Castillos F, Naughton M, Overmoyer B, Toppmeyer D, Witte JS, Owzar K, Kroetz DL. PMID: 30260474.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    12. Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle. Clin Pharmacol Ther. 2019 07; 106(1):148-163. Bartelink IH, Jones EF, Shahidi-Latham SK, Lee PRE, Zheng Y, Vicini P, van 't Veer L, Wolf D, Iagaru A, Kroetz DL, Prideaux B, Cilliers C, Thurber GM, Wimana Z, Gebhart G. PMID: 30107040.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    13. CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies. AIDS Res Hum Retroviruses. 2018 11; 34(11):982-992. Chang JL, Lee SA, Tsai AC, Musinguzi N, Muzoora C, Bwana B, Boum Y, Haberer JE, Hunt PW, Martin J, Bangsberg DR, Kroetz DL, Siedner MJ. PMID: 29973058.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance). Clin Cancer Res. 2018 10 01; 24(19):4734-4744. Li M, Mulkey F, Jiang C, O'Neil BH, Schneider BP, Shen F, Friedman PN, Momozawa Y, Kubo M, Niedzwiecki D, Hochster HS, Lenz HJ, Atkins JN, Rugo HS, Halabi S, Kelly WK, McLeod HL, Innocenti F, Ratain MJ, Venook AP, Owzar K, Kroetz DL. PMID: 29871907.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity. Drug Metab Dispos. 2018 05; 46(5):636-642. Eclov RJ, Kim MJ, Smith R, Ahituv N, Kroetz DL. PMID: 29467213.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci. Pharmacogenet Genomics. 2018 02; 28(2):49-55. Sucheston-Campbell LE, Clay-Gilmour AI, Barlow WE, Budd GT, Stram DO, Haiman CA, Sheng X, Yan L, Zirpoli G, Yao S, Jiang C, Owzar K, Hershman D, Albain KS, Hayes DF, Moore HC, Hobday TJ, Stewart JA, Rizvi A, Isaacs C, Salim M, Gralow JR, Hortobagyi GN, Livingston RB, Kroetz DL, Ambrosone CB. PMID: 29278617.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. Br J Clin Pharmacol. 2018 03; 84(3):510-519. Stage TB, Graff M, Wong S, Rasmussen LL, Nielsen F, Pottegård A, Brøsen K, Kroetz DL, Khojasteh SC, Damkier P. PMID: 29105855.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review. Clin Pharmacokinet. 2018 01; 57(1):7-19. Stage TB, Bergmann TK, Kroetz DL. PMID: 28612269.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    19. ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression. Pharmacogenet Genomics. 2017 Dec; 27(12):454-463. Eclov RJ, Kim MJ, Chhibber A, Smith RP, Ahituv N, Kroetz DL. PMID: 28930109.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Bevacizumab-induced hypertension: Clinical presentation and molecular understanding. Pharmacol Ther. 2018 02; 182:152-160. Li M, Kroetz DL. PMID: 28882537.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    21. In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus. Drug Metab Dispos. 2017 02; 45(2):208-215. Eclov RJ, Kim MJ, Smith RP, Liang X, Ahituv N, Kroetz DL. PMID: 27856528.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS. 2016 07 17; 30(11):1807-15. Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL. PMID: 27088321.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Clin Cancer Res. 2016 Oct 01; 22(19):4890-4900. Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel J, Halabi S, Furukawa Y, Wheeler HE, Sibley AB, Lassiter C, Weisman L, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz DL, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL. PMID: 27143689.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCTClinical Trials
    24. Multidrug resistance-associated protein 4 is a determinant of arsenite resistance. Oncol Rep. 2016 Jan; 35(1):147-54. Yuan B, Yoshino Y, Fukushima H, Markova S, Takagi N, Toyoda H, Kroetz DL. PMID: 26497925.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy. Clin Cancer Res. 2015 Oct 01; 21(19):4337-46. Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, Gorsic LK, Takahashi A, Kubo M, Kroetz DL, Zhang W, Nakamura Y, Dolan ME. PMID: 26015512.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. PharmGKB summary: very important pharmacogene information for human leukocyte antigen B. Pharmacogenet Genomics. 2015 Apr; 25(4):205-21. Barbarino JM, Kroetz DL, Klein TE, Altman RB. PMID: 25647431.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiol Dis. 2015 May; 77:127-40. Haenisch S, Zhao Y, Chhibber A, Kaiboriboon K, Do LV, Vogelgesang S, Barbaro NM, Alldredge BK, Lowenstein DH, Cascorbi I, Kroetz DL. PMID: 25766675.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics. 2014 Dec; 15(16):2025-48. Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA. PMID: 25521360.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    29. PharmGKB summary: abacavir pathway. Pharmacogenet Genomics. 2014 May; 24(5):276-82. Barbarino JM, Kroetz DL, Altman RB, Klein TE. PMID: 24625462.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. J Clin Pharmacol. 2014 May; 54(5):574-83. Nicol MR, Fedoriw Y, Mathews M, Prince HM, Patterson KB, Geller E, Mollan K, Mathews S, Kroetz DL, Kashuba AD. PMID: 24343710.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    31. Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes? Pharmacogenet Genomics. 2013 Nov; 23(11):591-6. Micheli JE, Chinn LW, Shugarts SB, Patel A, Martin JN, Bangsberg DR, Kroetz DL. PMID: 23982262.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. ABCC4 is regulated by microRNA-124a and microRNA-506. Biochem Pharmacol. 2014 Feb 01; 87(3):515-22. Markova SM, Kroetz DL. PMID: 24184504.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    33. Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway. Mol Pharmacol. 2013 Dec; 84(6):925-34. Liu Y, Lu X, Nguyen S, Olson JL, Webb HK, Kroetz DL. PMID: 24092818.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. Genome-wide association studies in pharmacogenomics: successes and lessons. Pharmacogenet Genomics. 2013 Aug; 23(8):383-94. Motsinger-Reif AA, Jorgenson E, Relling MV, Kroetz DL, Weinshilboum R, Cox NJ, Roden DM. PMID: 20639796.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    35. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet Genomics. 2013 Jul; 23(7):355-64. Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY. PMID: 23652407.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    36. Abacavir pharmacogenetics--from initial reports to standard of care. Pharmacotherapy. 2013 Jul; 33(7):765-75. Martin MA, Kroetz DL. PMID: 23649914.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Pharmacogenet Genomics. 2013 Jan; 23(1):29-33. Lewis LD, Miller AA, Owzar K, Bies RR, Markova S, Jiang C, Kroetz DL, Egorin MJ, McLeod HL, Ratain MJ, Alliance for Clinical Trials in Oncology . PMID: 23188068.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    38. Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. Clin Cancer Res. 2013 Jan 15; 19(2):491-9. Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer EP, Hudis CA, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cancer and Leukemia Group B , Cox NJ, Dolan ME. PMID: 23204130.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    39. Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial. J Natl Cancer Inst. 2012 Aug 22; 104(16):1264; author reply 1266-8. Nakamura Y, Ratain MJ, Cox NJ, McLeod HL, Kroetz DL, Flockhart DA. PMID: 22851270.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    40. A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. Clin Cancer Res. 2012 Sep 15; 18(18):5099-109. Baldwin RM, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL. PMID: 22843789.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    41. In vitro metabolism of piperaquine is primarily mediated by CYP3A4. Xenobiotica. 2012 Nov; 42(11):1088-95. Lee TM, Huang L, Johnson MK, Lizak P, Kroetz D, Aweeka F, Parikh S. PMID: 22671777.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    42. Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression. Pharmacogenomics J. 2013 Oct; 13(5):396-402. Nguyen TD, Markova S, Liu W, Gow JM, Baldwin RM, Habashian M, Relling MV, Ratain MJ, Kroetz DL. PMID: 22664480.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    43. Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor ?B signaling. J Pharmacol Exp Ther. 2012 Jun; 341(3):725-34. Liu Y, Webb HK, Fukushima H, Micheli J, Markova S, Olson JL, Kroetz DL. PMID: 22414856.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    44. Ethical aspects of participation in the database of genotypes and phenotypes of the National Center for Biotechnology Information: the Cancer and Leukemia Group B Experience. Cancer. 2012 Oct 15; 118(20):5060-8. Peppercorn J, Shapira I, Deshields T, Kroetz D, Friedman P, Spears P, Collyar DE, Shulman LN, Dressler L, Bertagnolli MM. PMID: 22415847.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    45. Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes. Toxicol Appl Pharmacol. 2011 Dec 01; 257(2):198-208. Yoshino Y, Yuan B, Kaise T, Takeichi M, Tanaka S, Hirano T, Kroetz DL, Toyoda H. PMID: 21945491.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011 May; 21(5):280-8. Marciante KD, Durda JP, Heckbert SR, Lumley T, Rice K, McKnight B, Totah RA, Tamraz B, Kroetz DL, Fukushima H, Kaspera R, Bis JC, Glazer NL, Li G, Austin TR, Taylor KD, Rotter JI, Jaquish CE, Kwok PY, Tracy RP, Psaty BM. PMID: 21386754.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    47. Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Pharmacogenet Genomics. 2011 Mar; 21(3):152-61. Hodges LM, Markova SM, Chinn LW, Gow JM, Kroetz DL, Klein TE, Altman RB. PMID: 20216335.
      View in: PubMed   Mentions: 109     Fields:    Translation:Humans
    48. Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine. Genome Biol. 2011; 12(1):301. Hoppe R, Brauch H, Kroetz DL, Esteller M. PMID: 21241526.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    49. Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains. Protein Sci. 2010 Nov; 19(11):2110-21. Kelly L, Fukushima H, Karchin R, Gow JM, Chinn LW, Pieper U, Segal MR, Kroetz DL, Sali A. PMID: 20799350.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    50. Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability. Pharmacogenet Genomics. 2010 Jan; 20(1):45-57. Ho RH, Leake BF, Kilkenny DM, Meyer Zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB. PMID: 20010382.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    51. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. PMID: 19842929.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    52. A survey of integral alpha-helical membrane proteins. J Struct Funct Genomics. 2009 Dec; 10(4):269-80. Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A. PMID: 19760129.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    53. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One. 2009 Sep 09; 4(9):e6942. Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. PMID: 19742321.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    54. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. J Clin Oncol. 2009 Jun 01; 27(16):2604-14. Innocenti F, Kroetz DL, Schuetz E, Dolan ME, Ramírez J, Relling M, Chen P, Das S, Rosner GL, Ratain MJ. PMID: 19349540.
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    55. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009 Mar 18; 29(11):3538-50. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton RJ. PMID: 19295159.
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    56. Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults. PLoS One. 2008; 3(12):e3981. Byakika-Tusiime J, Chinn LW, Oyugi JH, Obua C, Bangsberg DR, Kroetz DL. PMID: 19096711.
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    57. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008 Dec; 327(3):707-15. Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. PMID: 18815352.
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    58. Nicotine metabolism in pregnant and nonpregnant rabbits. Nicotine Tob Res. 2008 Aug; 10(8):1385-90. Tutka P, Dempsey DA, Jacob P, Benowitz NL, Kroetz DL. PMID: 18686186.
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    59. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. J Pharmacol Exp Ther. 2008 Jun; 325(3):859-68. Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL. PMID: 18364470.
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    60. Substrate-dependent effects of human ABCB1 coding polymorphisms. J Pharmacol Exp Ther. 2008 May; 325(2):435-42. Gow JM, Hodges LM, Chinn LW, Kroetz DL. PMID: 18287207.
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    61. The effects of ABCB1 3'-untranslated region variants on mRNA stability. Drug Metab Dispos. 2008 Jan; 36(1):10-5. Gow JM, Chinn LW, Kroetz DL. PMID: 17940136.
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    62. Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein. J Antimicrob Chemother. 2007 Jul; 60(1):61-7. Chinn LW, Gow JM, Tse MM, Becker SL, Kroetz DL. PMID: 17510066.
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    63. Adherence-resistance relationships to combination HIV antiretroviral therapy. Curr HIV/AIDS Rep. 2007 May; 4(2):65-72. Bangsberg DR, Kroetz DL, Deeks SG. PMID: 17547827.
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    64. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos. 2007 Jul; 35(7):1126-34. Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL. PMID: 17431031.
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    65. Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy. Epilepsia. 2007 Apr; 48(4):674-83. Soranzo N, Kelly L, Martinian L, Burley MW, Thom M, Sali A, Kroetz DL, Goldstein DB, Sisodiya SM. PMID: 17437410.
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    66. Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay. PLoS Genet. 2007 Mar 09; 3(3):e39. Jeong H, Herskowitz I, Kroetz DL, Rine J. PMID: 17352537.
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    67. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2462-8. Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. PMID: 16917105.
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    68. Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity. J Clin Oncol. 2006 Sep 10; 24(26):4225-7. Kroetz DL. PMID: 16895999.
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    69. CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease. J Pharmacol Exp Ther. 2006 Aug; 318(2):835-9. Xu F, Ng VY, Kroetz DL, de Montellano PR. PMID: 16707724.
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    70. MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. Drug Metab Pharmacokinet. 2006 Apr; 21(2):126-32. Komoto C, Nakamura T, Sakaeda T, Kroetz DL, Yamada T, Omatsu H, Koyama T, Okamura N, Miki I, Tamura T, Aoyama N, Kasuga M, Okumura K. PMID: 16702732.
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    71. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacol Rev. 2006 Mar; 58(1):3-4. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507878.
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    72. PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):1-2. Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL. PMID: 16507877.
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    73. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):5-6. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507879.
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    74. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. J Pharmacol Exp Ther. 2006 May; 317(2):732-8. Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL. PMID: 16421287.
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    75. Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests. Clin Pharmacol Ther. 2005 Dec; 78(6):559-81. Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K. PMID: 16338273.
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    76. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics. 2005 Oct; 15(10):693-704. Wang D, Johnson AD, Papp AC, Kroetz DL, Sadée W. PMID: 16141795.
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    77. Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. Annu Rev Pharmacol Toxicol. 2005; 45:413-38. Kroetz DL, Xu F. PMID: 15822183.
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    78. Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1). Pharm Res. 2004 Jun; 21(6):904-13. Pauli-Magnus C, Kroetz DL. PMID: 15212152.
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    79. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F720-6. Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. PMID: 14665429.
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    80. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. J Pharmacol Exp Ther. 2004 Mar; 308(3):887-95. Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL. PMID: 14634044.
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    81. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. PMID: 14586389.
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    82. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics. 2003 Aug; 13(8):481-94. Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG, Pharmacogenetics of Membrane Transporters Investigators . PMID: 12893986.
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    83. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5896-901. Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM, Pharmacogenetics Of Membrane Transporters Investigators . PMID: 12719533.
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    84. Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity. . 2002 Sep; 283(3):R710-20. Xu F, Straub WO, Pak W, Su P, Maier KG, Yu M, Roman RJ, Ortiz De Montellano PR, Kroetz DL. PMID: 12185006.
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    86. Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol. 2002 Jun; 13(3):273-83. Kroetz DL, Zeldin DC. PMID: 12045397.
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    87. Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. Biochemistry. 2002 May 07; 41(18):5931-7. LeBrun LA, Xu F, Kroetz DL, Ortiz de Montellano PR. PMID: 11980497.
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    88. Candidate gene approach for pharmacogenetic studies. Pharmacogenomics. 2002 Jan; 3(1):47-56. Ring HZ, Kroetz DL. PMID: 11966402.
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