Deanna Kroetz, PhD

Title(s)Professor Emeritus, Bioengineering
SchoolSchool of Pharmacy
Address1550 4th Street, Bldg 19B, #584E
San Francisco CA 94158
Phone415-476-1159
ORCID ORCID Icon0000-0001-5997-270X Additional info
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    Collapse Biography 
    Collapse Education and Training
    Ohio State University, Columbus, OHBS06/1985Pharmacy
    University of Washington, Seattle, WAPhD08/1990Pharmaceutics
    National Cancer Institute, Bethesda, MS06/1993Drug Metabolism
    Collapse Awards and Honors
    National Pharmaceutical Council 1984  - 1984National Pharmaceutical Council Internship Mortar Board Honor Society Rho Chi National Pharmacy Ho
    Cum Laude Graduate Ohio State University College of Pharmacy1985  - 1985Ohio State University Presidential Scholar Eli Lilly Company Achievement Award
    National Institute of Health Training1987  - 1990National Institute of Health Training Grant Trainee
    Pharmacology Research Associate Training1991  - 1993Pharmacology Research Associate Training (PRAT) Fellowship
    Ohio State University College of Pharmacy1995  - 1995Josephine S. Failer Alumni Award
    American Association of Pharmaceutical Scientists 1996  - 1996American Association of Pharmaceutical Scientists Young Investigator Award in Pharmacokinetics, Phar
    American Society for Clinical Pharmacology and Therapeutics2002  - 2002Leon I. Goldberg Young Investigator Award
    American Heart Association2002  - 2002Elected Fellow, High Blood Pressure Research Council of the American Heart Association
    American Association of Pharmaceutical Scientists2008  - 2008Elected Fellow, American Association of Pharmaceutical Scientists
    Pharmacology2008  - 2008Named to Faculty of 1000, Pharmacology
    UCSF School of Pharmacy 2009  - 2009Deans Apple Award for Teaching
    UCSF School of Pharmacy 2011  - 2011Deans Apple Award for Teaching
    Northern California Association for Women in Science 2014  - 2014Judith Pool Award for Mentoring
    UCSF School of Pharmacy2016  - 2016Deans Apple Award for Teaching
    UCSF School of Pharmacy2018  - 2018Deans Apple Award for Teaching
    American Association for the Advancement of Science2018  - 2018Elected Fellow
    University of Washington School of Pharmacy 2018  - 2018Distinguished Alumnus Award for Excellence in Pharmaceutical Sciences and Research
    UCSF School of Pharmacy2019  - 2019Deans Apple Award for Teaching
    American Society for Clinical Pharmacology and Therapeutics 2019  - 2019Mentor Award
    American College of Clinical Pharmacology2020  - 2020Bristol-Myers Squibb Mentorship in Clinical Pharmacology Award
    Advancement of Pharmacy2020  - 2020Jere E. Goyan Presidential Chair
    UCSF School of Pharmacy2020  - 2020Deans Apple Award for Teaching
    American Society for Clinical Pharmacology & Therapeutics ASCPT 2022  - 2022Rawls-Palmer Progress in Medicine Award

    Collapse Overview 
    Collapse Overview
    The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
    NIH R01CA261068Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Targeting MRP4-Mediated PGE2 Efflux to Improve Sensitivity to Immunotherapy
    The Cancer League Cancer CenterJun 1, 2020 - May 31, 2021
    Role: Principal Investigator
    Description: The goal of these pilot studies is to demonstrate that inhibition of MRP4-mediated efflux of PGE2 from tumor cells improves the response to immunotherapy.
    The Role of Genomics in Postoperative Delirium and Sedation
    NIH/NINR R01 NR017622Oct 1, 2019 - Sep 30, 2022
    Role: Co-investigator leading the genomic analyses
    Description: The goal of these studies is to identify genomic predictors of delirium and sedation in response to opiates following surgery in elderly patients. A predictive model will be developed to identify at risk patients prior to surgery and to modify opiate treatment to reduce risk of cognitive decline.
    Individualized Therapy for Recurrent Glioblastoma
    Private FoundationApr 1, 2018 - Mar 31, 2021
    Role: Co-investigator for pharmacology
    Description: The goal of these pilot studies is to use tumor sequencing to individualize therapy for patients with receurrent glioblastoma. The main outcome of this pilot study is the feasibility of exome sequencing for personalized therapy.
    Developing Silastic-Silicone for the Local Delivery of Hormonal Therapy to Prevent and Treat Breast Cancer
    NIH/NCI R01 CA220131Jul 1, 2017 - Jun 30, 2022
    Role: Co-Investigator
    Description: To develop a novel drug delivery tool to deliver high concentrations of approved and effective anti-estrogen directly to the breast parenchyma with minimal systemic exposure.
    Pharmacogenomics of Microtubule Targeting Agents
    NIH R01 CA192156-01A1Jul 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Description: The major goal of this study is to identify genetic predictors of microtubule targeting agent induced sensory peripheral neuropathy. Exome sequencing of samples from CALGB 40502 will be coupled with functional genomics studies to understand the molecular basis of this dose-limiting toxicity for paclitaxel and other microtubule targeting agents.
    Pharmaceutical Sciences and Pharmacogenomics
    NIH/NIGMS T32 GM007175-41Jul 1, 1982 - Jun 30, 2022
    Role: Principal Investigator
    Description: The goal of the PSPG graduate program is to educate and train Ph.D. students to conceptualize, design and execute innovative scientific research in the interdisciplinary scientific areas encompassed by modern pharmaceutical sciences.

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Modeling mechanisms of chemotherapy-induced peripheral neuropathy and chemotherapy transport using induced pluripotent stem cell-derived sensory neurons. Neuropharmacology. 2024 Jul 05; 258:110062. Mortensen C, Thomsen MT, Chua KC, Hammer HS, Nielsen F, Pötz O, Svenningsen AF, Kroetz DL, Stage TB. PMID: 38972371.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters. Pharmaceutics. 2024 May 10; 16(5). Kulkarni CP, Yang J, Koleske ML, Lara G, Alam K, Raw A, Rege B, Zhao L, Lu D, Zhang L, Yu LX, Lionberger RA, Giacomini KM, Kroetz DL, Yee SW. PMID: 38794309; PMCID: PMC11124870.
      View in: PubMed   Mentions:
    3. Structural basis of prostaglandin efflux by MRP4. Nat Struct Mol Biol. 2024 Apr; 31(4):621-632. Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM. PMID: 38216659; PMCID: PMC11145372.
      View in: PubMed   Mentions:    Fields:    
    4. Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size. AIDS. 2023 03 01; 37(3):477-488. Siegel DA, Thanh C, Wan E, Hoh R, Hobbs K, Pan T, Gibson EA, Kroetz DL, Martin J, Hecht F, Pilcher C, Martin M, Carrington M, Pillai S, Busch MP, Stone M, Levy CN, Huang ML, Roychoudhury P, Hladik F, Jerome KR, Kiem HP, Henrich TJ, Deeks SG, Lee SA. PMID: 36695358; PMCID: PMC9894159.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. Clin Pharmacol Ther. 2022 09; 112(3):540-561. Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. PMID: 35488474; PMCID: PMC9398938.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    6. Correction: Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients. Br J Cancer. 2022 Jan; 126(1):162. Quintanilha JCF, Wang J, Sibley AB, Jiang C, Etheridge AS, Shen F, Jiang G, Mulkey F, Patel JN, Hertz DL, Dees EC, McLeod HL, Bertagnolli M, Rugo H, Kindler HL, Kelly WK, Ratain MJ, Kroetz DL, Owzar K, Schneider BP, Lin D, Innocenti F. PMID: 34853435; PMCID: PMC8727676.
      View in: PubMed   Mentions:    Fields:    
    7. Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients. Br J Cancer. 2022 02; 126(2):265-274. Quintanilha JCF, Wang J, Sibley AB, Jiang C, Etheridge AS, Shen F, Jiang G, Mulkey F, Patel JN, Hertz DL, Dees EC, McLeod HL, Bertagnolli M, Rugo H, Kindler HL, Kelly WK, Ratain MJ, Kroetz DL, Owzar K, Schneider BP, Lin D, Innocenti F. PMID: 34616010; PMCID: PMC8770703.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    8. Mechanistic insights into the pathogenesis of microtubule-targeting agent-induced peripheral neuropathy from pharmacogenetic and functional studies. Basic Clin Pharmacol Toxicol. 2022 Jan; 130 Suppl 1:60-74. Chua KC, El-Haj N, Priotti J, Kroetz DL. PMID: 34481421; PMCID: PMC8716520.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein. AAPS J. 2021 09 15; 23(5):106. Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL. PMID: 34528148; PMCID: PMC9148196.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. In-depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry. Anal Chim Acta. 2021 Nov 01; 1184:339023. Cabruja M, Priotti J, Domizi P, Papsdorf K, Kroetz DL, Brunet A, Contrepois K, Snyder MP. PMID: 34625255; PMCID: PMC8502232.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel. Clin Transl Sci. 2021 03; 14(2):568-581. Xiong C, Chua KC, Stage TB, Priotti J, Kim J, Altman-Merino A, Chan D, Saraf K, Canato Ferracini A, Fattahi F, Kroetz DL. PMID: 33340242; PMCID: PMC7993321.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    12. GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer. Clin Transl Sci. 2021 03; 14(2):720-728. Ferracini AC, Lopes-Aguiar L, Lourenço GJ, Yoshida A, Lima CSP, Sarian LO, Derchain S, Kroetz DL, Mazzola PG. PMID: 33326171; PMCID: PMC7993324.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    13. Role for Drug Transporters in Chemotherapy-Induced Peripheral Neuropathy. Clin Transl Sci. 2021 03; 14(2):460-467. Stage TB, Hu S, Sparreboom A, Kroetz DL. PMID: 33142018; PMCID: PMC7993259.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy. Clin Pharmacol Ther. 2020 09; 108(3):625-634. Chua KC, Xiong C, Ho C, Mushiroda T, Jiang C, Mulkey F, Lai D, Schneider BP, Rashkin SR, Witte JS, Friedman PN, Ratain MJ, McLeod HL, Rugo HS, Shulman LN, Kubo M, Owzar K, Kroetz DL. PMID: 32562552; PMCID: PMC7718413.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer. Clin Pharmacol Ther. 2020 09; 108(3):671-680. Stage TB, Mortensen C, Khalaf S, Steffensen V, Hammer HS, Xiong C, Nielsen F, Poetz O, Svenningsen ÅF, Rodriguez-Antona C, Kroetz DL. PMID: 32275773; PMCID: PMC8135112.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Reversible inhibition of efflux transporters by hydrogel microdevices. Eur J Pharm Biopharm. 2019 Dec; 145:76-84. Levy ES, Samy KE, Lamson NG, Whitehead KA, Kroetz DL, Desai TA. PMID: 31639417; PMCID: PMC6919324.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Efficient estimation of grouped survival models. BMC Bioinformatics. 2019 May 28; 20(1):269. Li Z, Lin J, Sibley AB, Truong T, Chua KC, Jiang Y, McCarthy J, Kroetz DL, Allen A, Owzar K. PMID: 31138120; PMCID: PMC6540566.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clin Transl Sci. 2019 07; 12(4):388-399. Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM. PMID: 30982223; PMCID: PMC6662551.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    19. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing. J Pharmacol Exp Ther. 2019 06; 369(3):523-530. Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S. PMID: 30910922; PMCID: PMC11047058.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service. J Am Coll Clin Pharm. 2019 Jun; 2(3):214-221. Zakinova A, Long-Boyle JR, French D, Croci R, Wilson L, Phillips KA, Kroetz DL, Shin J, Tamraz B. PMID: 32391517; PMCID: PMC7207007.
      View in: PubMed   Mentions: 4  
    21. A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance). Clin Pharmacol Ther. 2019 03; 105(3):738-745. Rashkin SR, Chua KC, Ho C, Mulkey F, Jiang C, Mushiroda T, Kubo M, Friedman PN, Rugo HS, McLeod HL, Ratain MJ, Castillos F, Naughton M, Overmoyer B, Toppmeyer D, Witte JS, Owzar K, Kroetz DL. PMID: 30260474; PMCID: PMC6379108.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    22. Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle. Clin Pharmacol Ther. 2019 07; 106(1):148-163. Bartelink IH, Jones EF, Shahidi-Latham SK, Lee PRE, Zheng Y, Vicini P, van 't Veer L, Wolf D, Iagaru A, Kroetz DL, Prideaux B, Cilliers C, Thurber GM, Wimana Z, Gebhart G. PMID: 30107040; PMCID: PMC6617978.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    23. CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies. AIDS Res Hum Retroviruses. 2018 11; 34(11):982-992. Chang JL, Lee SA, Tsai AC, Musinguzi N, Muzoora C, Bwana B, Boum Y, Haberer JE, Hunt PW, Martin J, Bangsberg DR, Kroetz DL, Siedner MJ. PMID: 29973058; PMCID: PMC6238612.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance). Clin Cancer Res. 2018 10 01; 24(19):4734-4744. Li M, Mulkey F, Jiang C, O'Neil BH, Schneider BP, Shen F, Friedman PN, Momozawa Y, Kubo M, Niedzwiecki D, Hochster HS, Lenz HJ, Atkins JN, Rugo HS, Halabi S, Kelly WK, McLeod HL, Innocenti F, Ratain MJ, Venook AP, Owzar K, Kroetz DL. PMID: 29871907; PMCID: PMC6168379.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    25. Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity. Drug Metab Dispos. 2018 05; 46(5):636-642. Eclov RJ, Kim MJ, Smith R, Ahituv N, Kroetz DL. PMID: 29467213; PMCID: PMC5896364.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci. Pharmacogenet Genomics. 2018 02; 28(2):49-55. Sucheston-Campbell LE, Clay-Gilmour AI, Barlow WE, Budd GT, Stram DO, Haiman CA, Sheng X, Yan L, Zirpoli G, Yao S, Jiang C, Owzar K, Hershman D, Albain KS, Hayes DF, Moore HC, Hobday TJ, Stewart JA, Rizvi A, Isaacs C, Salim M, Gralow JR, Hortobagyi GN, Livingston RB, Kroetz DL, Ambrosone CB. PMID: 29278617; PMCID: PMC5824720.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    27. Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. Br J Clin Pharmacol. 2018 03; 84(3):510-519. Stage TB, Graff M, Wong S, Rasmussen LL, Nielsen F, Pottegård A, Brøsen K, Kroetz DL, Khojasteh SC, Damkier P. PMID: 29105855; PMCID: PMC5809358.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review. Clin Pharmacokinet. 2018 01; 57(1):7-19. Stage TB, Bergmann TK, Kroetz DL. PMID: 28612269; PMCID: PMC8572663.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    29. ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression. Pharmacogenet Genomics. 2017 Dec; 27(12):454-463. Eclov RJ, Kim MJ, Chhibber A, Smith RP, Ahituv N, Kroetz DL. PMID: 28930109; PMCID: PMC5678922.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    30. Bevacizumab-induced hypertension: Clinical presentation and molecular understanding. Pharmacol Ther. 2018 02; 182:152-160. Li M, Kroetz DL. PMID: 28882537; PMCID: PMC5785435.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    31. Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy. Clin Pharmacol Ther. 2017 04; 101(4):450-452. Chua KC, Kroetz DL. PMID: 27981569; PMCID: PMC5359049.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    32. In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus. Drug Metab Dispos. 2017 02; 45(2):208-215. Eclov RJ, Kim MJ, Smith RP, Liang X, Ahituv N, Kroetz DL. PMID: 27856528; PMCID: PMC5267518.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    33. ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia. Pharmacogenomics J. 2018 01; 18(1):35-42. Li M, Seiser EL, Baldwin RM, Ramirez J, Ratain MJ, Innocenti F, Kroetz DL. PMID: 27845419; PMCID: PMC5432414.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    34. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Nov; 100(5):524-536. Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. PMID: 27447836; PMCID: PMC6365106.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCellsCTClinical Trials
    35. Best Practices for Clinical and Translational Research and Implementation. Clin Transl Sci. 2016 Oct; 9(5):231-232. Kroetz DL. PMID: 27546282; PMCID: PMC5350994.
      View in: PubMed   Mentions: 1     Fields:    
    36. Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS. 2016 07 17; 30(11):1807-15. Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL. PMID: 27088321; PMCID: PMC4925250.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Clin Cancer Res. 2016 Oct 01; 22(19):4890-4900. Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel J, Halabi S, Furukawa Y, Wheeler HE, Sibley AB, Lassiter C, Weisman L, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz DL, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL. PMID: 27143689; PMCID: PMC5050068.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCTClinical Trials
    38. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2017 03; 17(2):137-145. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. PMID: 26856248; PMCID: PMC4980276.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    39. Transforming Translation: Impact of Clinical and Translational Science. Clin Transl Sci. 2016 Feb; 9(1):3-5. Wagner JA, Kroetz DL. PMID: 26678255; PMCID: PMC5351317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Multidrug resistance-associated protein 4 is a determinant of arsenite resistance. Oncol Rep. 2016 Jan; 35(1):147-54. Yuan B, Yoshino Y, Fukushima H, Markova S, Takagi N, Toyoda H, Kroetz DL. PMID: 26497925; PMCID: PMC6918809.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    41. Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy. Clin Cancer Res. 2015 Oct 01; 21(19):4337-46. Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, Gorsic LK, Takahashi A, Kubo M, Kroetz DL, Zhang W, Nakamura Y, Dolan ME. PMID: 26015512; PMCID: PMC4592389.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    42. PharmGKB summary: very important pharmacogene information for human leukocyte antigen B. Pharmacogenet Genomics. 2015 Apr; 25(4):205-21. Barbarino JM, Kroetz DL, Klein TE, Altman RB. PMID: 25647431; PMCID: PMC4356642.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients. Neurobiol Dis. 2015 May; 77:127-40. Haenisch S, Zhao Y, Chhibber A, Kaiboriboon K, Do LV, Vogelgesang S, Barbaro NM, Alldredge BK, Lowenstein DH, Cascorbi I, Kroetz DL. PMID: 25766675; PMCID: PMC4404495.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics. 2014 Dec; 15(16):2025-48. Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA. PMID: 25521360; PMCID: PMC4308414.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    45. PharmGKB summary: abacavir pathway. Pharmacogenet Genomics. 2014 May; 24(5):276-82. Barbarino JM, Kroetz DL, Altman RB, Klein TE. PMID: 24625462; PMCID: PMC4074515.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update. Clin Pharmacol Ther. 2014 May; 95(5):499-500. Martin MA, Hoffman JM, Freimuth RR, Klein TE, Dong BJ, Pirmohamed M, Hicks JK, Wilkinson MR, Haas DW, Kroetz DL, Clinical Pharmacogenetics Implementation Consortium. PMID: 24561393; PMCID: PMC3994233.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    47. Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). Pharmacogenomics J. 2014 Aug; 14(4):336-42. Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, Kroetz DL. PMID: 24513692; PMCID: PMC4111770.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCellsCTClinical Trials
    48. Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. J Clin Pharmacol. 2014 May; 54(5):574-83. Nicol MR, Fedoriw Y, Mathews M, Prince HM, Patterson KB, Geller E, Mollan K, Mathews S, Kroetz DL, Kashuba AD. PMID: 24343710; PMCID: PMC4061289.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    49. Response to "CYP2C9 polymorphism is not a major determinant of bosentan exposure in healthy volunteers". Clin Pharmacol Ther. 2014 Mar; 95(3):252. Markova SM, Schwartz JB, Kroetz DL. PMID: 24346422.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes? Pharmacogenet Genomics. 2013 Nov; 23(11):591-6. Micheli JE, Chinn LW, Shugarts SB, Patel A, Martin JN, Bangsberg DR, Kroetz DL. PMID: 23982262; PMCID: PMC4048019.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. ABCC4 is regulated by microRNA-124a and microRNA-506. Biochem Pharmacol. 2014 Feb 01; 87(3):515-22. Markova SM, Kroetz DL. PMID: 24184504; PMCID: PMC3927324.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    52. Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway. Mol Pharmacol. 2013 Dec; 84(6):925-34. Liu Y, Lu X, Nguyen S, Olson JL, Webb HK, Kroetz DL. PMID: 24092818; PMCID: PMC3834146.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    53. Genome-wide association studies in pharmacogenomics: successes and lessons. Pharmacogenet Genomics. 2013 Aug; 23(8):383-94. Motsinger-Reif AA, Jorgenson E, Relling MV, Kroetz DL, Weinshilboum R, Cox NJ, Roden DM. PMID: 20639796; PMCID: PMC3003940.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    54. Association of CYP2C9*2 with bosentan-induced liver injury. Clin Pharmacol Ther. 2013 Dec; 94(6):678-86. Markova SM, De Marco T, Bendjilali N, Kobashigawa EA, Mefford J, Sodhi J, Le H, Zhang C, Halladay J, Rettie AE, Khojasteh C, McGlothlin D, Wu AH, Hsueh WC, Witte JS, Schwartz JB, Kroetz DL. PMID: 23863877; PMCID: PMC3834031.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet Genomics. 2013 Jul; 23(7):355-64. Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY. PMID: 23652407; PMCID: PMC3894639.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    56. Abacavir pharmacogenetics--from initial reports to standard of care. Pharmacotherapy. 2013 Jul; 33(7):765-75. Martin MA, Kroetz DL. PMID: 23649914; PMCID: PMC3700656.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    57. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Pharmacogenet Genomics. 2013 Jan; 23(1):29-33. Lewis LD, Miller AA, Owzar K, Bies RR, Markova S, Jiang C, Kroetz DL, Egorin MJ, McLeod HL, Ratain MJ, Alliance for Clinical Trials in Oncology. PMID: 23188068; PMCID: PMC3647228.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    58. Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. Clin Cancer Res. 2013 Jan 15; 19(2):491-9. Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer EP, Hudis CA, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cancer and Leukemia Group B, Cox NJ, Dolan ME. PMID: 23204130; PMCID: PMC3549006.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    59. Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial. J Natl Cancer Inst. 2012 Aug 22; 104(16):1264; author reply 1266-8. Nakamura Y, Ratain MJ, Cox NJ, McLeod HL, Kroetz DL, Flockhart DA. PMID: 22851270.
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    60. A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. Clin Cancer Res. 2012 Sep 15; 18(18):5099-109. Baldwin RM, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL. PMID: 22843789; PMCID: PMC3445665.
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    61. In vitro metabolism of piperaquine is primarily mediated by CYP3A4. Xenobiotica. 2012 Nov; 42(11):1088-95. Lee TM, Huang L, Johnson MK, Lizak P, Kroetz D, Aweeka F, Parikh S. PMID: 22671777; PMCID: PMC5087332.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    62. Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression. Pharmacogenomics J. 2013 Oct; 13(5):396-402. Nguyen TD, Markova S, Liu W, Gow JM, Baldwin RM, Habashian M, Relling MV, Ratain MJ, Kroetz DL. PMID: 22664480; PMCID: PMC3435480.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    63. Ethical aspects of participation in the database of genotypes and phenotypes of the National Center for Biotechnology Information: the Cancer and Leukemia Group B Experience. Cancer. 2012 Oct 15; 118(20):5060-8. Peppercorn J, Shapira I, Deshields T, Kroetz D, Friedman P, Spears P, Collyar DE, Shulman LN, Dressler L, Bertagnolli MM. PMID: 22415847.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    64. Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling. J Pharmacol Exp Ther. 2012 Jun; 341(3):725-34. Liu Y, Webb HK, Fukushima H, Micheli J, Markova S, Olson JL, Kroetz DL. PMID: 22414856; PMCID: PMC3362876.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    65. Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing. Clin Pharmacol Ther. 2012 Apr; 91(4):734-8. Martin MA, Klein TE, Dong BJ, Pirmohamed M, Haas DW, Kroetz DL, Clinical Pharmacogenetics Implementation Consortium. PMID: 22378157; PMCID: PMC3374459.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    66. Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes. Toxicol Appl Pharmacol. 2011 Dec 01; 257(2):198-208. Yoshino Y, Yuan B, Kaise T, Takeichi M, Tanaka S, Hirano T, Kroetz DL, Toyoda H. PMID: 21945491; PMCID: PMC3470788.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    67. Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011 May; 21(5):280-8. Marciante KD, Durda JP, Heckbert SR, Lumley T, Rice K, McKnight B, Totah RA, Tamraz B, Kroetz DL, Fukushima H, Kaspera R, Bis JC, Glazer NL, Li G, Austin TR, Taylor KD, Rotter JI, Jaquish CE, Kwok PY, Tracy RP, Psaty BM. PMID: 21386754; PMCID: PMC3076530.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    68. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Pharmacogenomics J. 2012 Jun; 12(3):214-26. Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM. PMID: 21383772; PMCID: PMC3325368.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    69. Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther. 2011 Apr; 89(4):571-8. Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. PMID: 21368754; PMCID: PMC3227682.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    70. Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Pharmacogenet Genomics. 2011 Mar; 21(3):152-61. Hodges LM, Markova SM, Chinn LW, Gow JM, Kroetz DL, Klein TE, Altman RB. PMID: 20216335; PMCID: PMC3098758.
      View in: PubMed   Mentions: 178     Fields:    Translation:Humans
    71. Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine. Genome Biol. 2011; 12(1):301. Hoppe R, Brauch H, Kroetz DL, Esteller M. PMID: 21241526; PMCID: PMC3091296.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    72. Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains. Protein Sci. 2010 Nov; 19(11):2110-21. Kelly L, Fukushima H, Karchin R, Gow JM, Chinn LW, Pieper U, Segal MR, Kroetz DL, Sali A. PMID: 20799350; PMCID: PMC3005782.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    73. Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability. Pharmacogenet Genomics. 2010 Jan; 20(1):45-57. Ho RH, Leake BF, Kilkenny DM, Meyer Zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB. PMID: 20010382; PMCID: PMC2883163.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    74. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clin Pharmacol Ther. 2010 Jan; 87(1):109-16. Kroetz DL, Yee SW, Giacomini KM. PMID: 19940846; PMCID: PMC2923224.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    75. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. PMID: 19842929; PMCID: PMC2923222.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    76. A survey of integral alpha-helical membrane proteins. J Struct Funct Genomics. 2009 Dec; 10(4):269-80. Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A. PMID: 19760129; PMCID: PMC2780624.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    77. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One. 2009 Sep 09; 4(9):e6942. Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. PMID: 19742321; PMCID: PMC2735003.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    78. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. J Clin Oncol. 2009 Jun 01; 27(16):2604-14. Innocenti F, Kroetz DL, Schuetz E, Dolan ME, Ramírez J, Relling M, Chen P, Das S, Rosner GL, Ratain MJ. PMID: 19349540; PMCID: PMC2690389.
      View in: PubMed   Mentions: 108     Fields:    Translation:Humans
    79. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009 Mar 18; 29(11):3538-50. Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton RJ. PMID: 19295159; PMCID: PMC3040577.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    80. Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults. PLoS One. 2008; 3(12):e3981. Byakika-Tusiime J, Chinn LW, Oyugi JH, Obua C, Bangsberg DR, Kroetz DL. PMID: 19096711; PMCID: PMC2602850.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    81. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther. 2008 Dec; 327(3):707-15. Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. PMID: 18815352; PMCID: PMC2761654.
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    82. Nicotine metabolism in pregnant and nonpregnant rabbits. Nicotine Tob Res. 2008 Aug; 10(8):1385-90. Tutka P, Dempsey DA, Jacob P, Benowitz NL, Kroetz DL. PMID: 18686186; PMCID: PMC2923225.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    83. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. J Pharmacol Exp Ther. 2008 Jun; 325(3):859-68. Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL. PMID: 18364470; PMCID: PMC2612728.
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    84. Substrate-dependent effects of human ABCB1 coding polymorphisms. J Pharmacol Exp Ther. 2008 May; 325(2):435-42. Gow JM, Hodges LM, Chinn LW, Kroetz DL. PMID: 18287207; PMCID: PMC2612726.
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    85. The effects of ABCB1 3'-untranslated region variants on mRNA stability. Drug Metab Dispos. 2008 Jan; 36(1):10-5. Gow JM, Chinn LW, Kroetz DL. PMID: 17940136.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    86. Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein. J Antimicrob Chemother. 2007 Jul; 60(1):61-7. Chinn LW, Gow JM, Tse MM, Becker SL, Kroetz DL. PMID: 17510066.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    87. Adherence-resistance relationships to combination HIV antiretroviral therapy. Curr HIV/AIDS Rep. 2007 May; 4(2):65-72. Bangsberg DR, Kroetz DL, Deeks SG. PMID: 17547827.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    88. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos. 2007 Jul; 35(7):1126-34. Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL. PMID: 17431031.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    89. Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy. Epilepsia. 2007 Apr; 48(4):674-83. Soranzo N, Kelly L, Martinian L, Burley MW, Thom M, Sali A, Kroetz DL, Goldstein DB, Sisodiya SM. PMID: 17437410.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    90. Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug; 82(2):197-203. Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL. PMID: 17361129.
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    91. Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay. PLoS Genet. 2007 Mar 09; 3(3):e39. Jeong H, Herskowitz I, Kroetz DL, Rine J. PMID: 17352537; PMCID: PMC1817653.
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    92. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007 Mar; 81(3):328-45. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I, Pharmacogenetics Research Network. PMID: 17339863; PMCID: PMC5006950.
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    93. ABCB1 pharmacogenetics: progress, pitfalls, and promise. Clin Pharmacol Ther. 2007 Feb; 81(2):265-9. Chinn LW, Kroetz DL. PMID: 17259950.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    94. Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther. 2007 Jan; 81(1):42-9. de Jong FA, Scott-Horton TJ, Kroetz DL, McLeod HL, Friberg LE, Mathijssen RH, Verweij J, Marsh S, Sparreboom A. PMID: 17185998.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    95. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2462-8. Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. PMID: 16917105; PMCID: PMC1904341.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    96. Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity. J Clin Oncol. 2006 Sep 10; 24(26):4225-7. Kroetz DL. PMID: 16895999.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    97. CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease. J Pharmacol Exp Ther. 2006 Aug; 318(2):835-9. Xu F, Ng VY, Kroetz DL, de Montellano PR. PMID: 16707724.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    98. MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. Drug Metab Pharmacokinet. 2006 Apr; 21(2):126-32. Komoto C, Nakamura T, Sakaeda T, Kroetz DL, Yamada T, Omatsu H, Koyama T, Okamura N, Miki I, Tamura T, Aoyama N, Kasuga M, Okumura K. PMID: 16702732.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    99. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):5-6. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507879.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    100. PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):1-2. Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL. PMID: 16507877.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    101. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacol Rev. 2006 Mar; 58(1):3-4. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PMID: 16507878.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    102. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. J Pharmacol Exp Ther. 2006 May; 317(2):732-8. Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL. PMID: 16421287.
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    103. Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests. Clin Pharmacol Ther. 2005 Dec; 78(6):559-81. Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K. PMID: 16338273.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    104. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics. 2005 Oct; 15(10):693-704. Wang D, Johnson AD, Papp AC, Kroetz DL, Sadée W. PMID: 16141795.
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    105. Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2005 Sep; 289(3):F552-61. Seubert JM, Xu F, Graves JP, Collins JB, Sieber SO, Paules RS, Kroetz DL, Zeldin DC. PMID: 15798089.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    106. Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. Annu Rev Pharmacol Toxicol. 2005; 45:413-38. Kroetz DL, Xu F. PMID: 15822183.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    107. Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1). Pharm Res. 2004 Jun; 21(6):904-13. Pauli-Magnus C, Kroetz DL. PMID: 15212152.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    108. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F720-6. Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. PMID: 14665429.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    109. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. J Pharmacol Exp Ther. 2004 Mar; 308(3):887-95. Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL. PMID: 14634044.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    110. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. PMID: 14586389.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    111. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics. 2003 Aug; 13(8):481-94. Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG, Pharmacogenetics of Membrane Transporters Investigators. PMID: 12893986.
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    112. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5896-901. Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM, Pharmacogenetics Of Membrane Transporters Investigators. PMID: 12719533; PMCID: PMC156298.
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    113. Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity. Am J Physiol Regul Integr Comp Physiol. 2002 Sep; 283(3):R710-20. Xu F, Straub WO, Pak W, Su P, Maier KG, Yu M, Roman RJ, Ortiz De Montellano PR, Kroetz DL. PMID: 12185006.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    114. MDR1 reference sequence and reference function. Clin Pharmacol Ther. 2002 Jul; 72(1):100-1. Pauli-Magnus C, Kroetz DL. PMID: 12152008.
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    115. Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol. 2002 Jun; 13(3):273-83. Kroetz DL, Zeldin DC. PMID: 12045397.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    116. Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. Biochemistry. 2002 May 07; 41(18):5931-7. LeBrun LA, Xu F, Kroetz DL, Ortiz de Montellano PR. PMID: 11980497.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    117. Candidate gene approach for pharmacogenetic studies. Pharmacogenomics. 2002 Jan; 3(1):47-56. Ring HZ, Kroetz DL. PMID: 11966402.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    118. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res. 2000 Nov 24; 87(11):992-8. Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL. PMID: 11090543.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    119. Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Mol Pharmacol. 2000 May; 57(5):1011-20. Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, Kroetz DL. PMID: 10779386.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    120. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar; 28(3):329-34. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM. PMID: 10681378.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    121. Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid. Pharm Res. 2000 Feb; 17(2):216-21. Spiegelstein O, Kroetz DL, Levy RH, Yagen B, Hurst SI, Levi M, Haj-Yehia A, Bialer M. PMID: 10751038.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    122. Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. Arch Biochem Biophys. 2000 Jan 01; 373(1):63-71. Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR. PMID: 10620324.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    123. The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1999 Nov; 61(5):289-95. Engler MM, Engler MB, Kroetz DL, Boswell KD, Neeley E, Krassner SM. PMID: 10670690.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    124. Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. Proc Soc Exp Biol Med. 1999 May; 221(1):32-8. Engler MM, Engler MB, Goodfriend TL, Ball DL, Yu Z, Su P, Kroetz DL. PMID: 10320629.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    125. Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J Biol Chem. 1998 Nov 20; 273(47):31581-9. Kroetz DL, Yook P, Costet P, Bianchi P, Pineau T. PMID: 9813074.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    126. Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe. Biochemistry. 1998 Sep 08; 37(36):12536-45. Wang H, Dick R, Yin H, Licad-Coles E, Kroetz DL, Szklarz G, Harlow G, Halpert JR, Correia MA. PMID: 9730826.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    127. Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. Am J Physiol. 1998 08; 275(2):R426-38. Su P, Kaushal KM, Kroetz DL. PMID: 9688677.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    128. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Mol Pharmacol. 1997 Sep; 52(3):362-72. Kroetz DL, Huse LM, Thuresson A, Grillo MP. PMID: 9281597.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    129. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 1995 Jun; 15(6):3012-22. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ. PMID: 7539101; PMCID: PMC230532.
      View in: PubMed   Mentions: 416     Fields:    Translation:AnimalsCells
    130. Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem Pharmacol. 1994 Jun 01; 47(11):1969-79. Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FJ, Levy RH. PMID: 8010982.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    131. Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms. Biochemistry. 1993 Nov 02; 32(43):11606-17. Kroetz DL, McBride OW, Gonzalez FJ. PMID: 8218228.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    132. In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide. Clin Pharmacol Ther. 1993 Nov; 54(5):485-97. Kroetz DL, Loiseau P, Guyot M, Levy RH. PMID: 8222491.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    133. Carbamazepine-valnoctamide interaction in epileptic patients: in vitro/in vivo correlation. Epilepsia. 1993 Sep-Oct; 34(5):954-9. Pisani F, Haj-Yehia A, Fazio A, Artesi C, Oteri G, Perucca E, Kroetz DL, Levy RH, Bialer M. PMID: 8104783.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    134. Measurement of in vivo microsomal epoxide hydrolase activity in white subjects. Clin Pharmacol Ther. 1993 Mar; 53(3):306-15. Kroetz DL, Kerr BM, McFarland LV, Loiseau P, Wilensky AJ, Levy RH. PMID: 8453849.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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