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James Grenert, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPathology
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-502-3252
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    Collapse Biography 
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    MayoM.D.2000School of Medicine

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wen KW, Grenert J, Joseph NM, Shafizadeh N, Huang A, Hosseini M, Kakar S. Genomic Profile of Appendiceal Goblet Cell Carcinoid Is Distinct Compared to Appendiceal Neuroendocrine Tumor and Conventional Adenocarcinoma. Hum Pathol. 2018 Apr 07. PMID: 29634977.
      View in: PubMed
    2. Yan Z, Grenert J, Joseph NM, Xu C, Chen X, Shafizadeh N, Kakar S. Hepatic Angiomyolipoma: Mutation Analysis and Immunohistochemical Pitfalls in Diagnosis. Histopathology. 2018 Mar 07. PMID: 29512829.
      View in: PubMed
    3. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert J, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. PMID: 29476136.
      View in: PubMed
    4. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert J, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 Apr; 135(4):635-638. PMID: 29435664.
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    5. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert J, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2017 Nov 17. PMID: 29148537.
      View in: PubMed
    6. Sirohi D, Garg K, Simko JP, Grenert J. Renal NUT carcinoma: a case report. Histopathology. 2018 Feb; 72(3):528-530. PMID: 28837236.
      View in: PubMed
    7. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert J, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673. PMID: 28776091.
      View in: PubMed
    8. Foley N, Van Ziffle J, Yu J, Qi Z, Grenert J, Yeh I, Bastian B, Kogan S, Mannis GN. Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation? Cancer Genet. 2017 Oct; 216-217:74-78. PMID: 29025598.
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    9. Can NT, Grenert J, Vohra P. Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver. Pathol Res Pract. 2017 Oct; 213(10):1306-1309. PMID: 28756985.
      View in: PubMed
    10. Krings G, Joseph NM, Bean GR, Solomon D, Onodera C, Talevich E, Yeh I, Grenert J, Hosfield E, Crawford ED, Jordan RC, van Zante A, Zaloudek C, Shin SJ, Chen YY. Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. Mod Pathol. 2017 Aug; 30(8):1086-1099. PMID: 28548128.
      View in: PubMed
    11. Kline CN, Joseph NM, Grenert J, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. PMID: 28453743.
      View in: PubMed
    12. Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert J, Cho SJ, Maher JJ. Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):223-236. PMID: 28649594.
      View in: PubMed
    13. DeParis SW, Bloomer M, Han Y, Vagefi MR, Shieh JTC, Solomon DA, Grenert J, de Alba Campomanes AG. Uveal Ganglioneuroma due to Germline PTEN Mutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma. Ocul Oncol Pathol. 2017 Jul; 3(2):122-128. PMID: 28868283.
      View in: PubMed
    14. Kim SM, Grenert J, Patterson C, Correia MA. CHIP(-/-)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications. Sci Rep. 2016 Jul 12; 6:29423. PMID: 27406999; PMCID: PMC4942616.
      View in: PubMed, PubMed Central
    15. Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert J, Bastian BC, Chen YY, Krings G. Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity. Mod Pathol. 2016 09; 29(9):1012-27. PMID: 27255162.
      View in: PubMed
    16. Desai SS, Tung JC, Zhou VX, Grenert J, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. Hepatology. 2016 07; 64(1):261-75. PMID: 26755329.
      View in: PubMed
    17. Kline CN, Joseph NM, Grenert J, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 05; 18(5):752-3. PMID: 26902849; PMCID: PMC4827050 [Available on 05/01/17].
      View in: PubMed, PubMed Central
    18. Pierce AA, Duwaerts CC, Soon RK, Siao K, Grenert J, Fitch M, Hellerstein MK, Beysen C, Turner SM, Maher JJ. Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury. J Nutr Biochem. 2016 Mar; 29:12-20. PMID: 26895660; PMCID: PMC4761406 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    19. Pierce AA, Pickens MK, Siao K, Grenert J, Maher JJ. Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis. BMC Gastroenterol. 2015 Jun 24; 15:72. PMID: 26103964; PMCID: PMC4479079.
      View in: PubMed, PubMed Central
    20. Rabban JT, Calkins SM, Karnezis AN, Grenert J, Blanco A, Crawford B, Chen LM. Association of tumor morphology with mismatch-repair protein status in older endometrial cancer patients: implications for universal versus selective screening strategies for Lynch syndrome. Am J Surg Pathol. 2014 Jun; 38(6):793-800. PMID: 24503759.
      View in: PubMed
    21. Davis JL, Grenert J, Horvai AE. Loss of heterozygosity and microsatellite instability are rare in sporadic dedifferentiated liposarcoma: a study of 43 well-characterized cases. Arch Pathol Lab Med. 2014 Jun; 138(6):823-7. PMID: 24878023.
      View in: PubMed
    22. Kakar S, Grenert J, Paradis V, Pote N, Jakate S, Ferrell LD. Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor. Mod Pathol. 2014 Nov; 27(11):1499-1509. PMID: 24743216; PMCID: PMC4803443.
      View in: PubMed, PubMed Central
    23. Gouveia C, Can NT, Bostrom A, Grenert J, van Zante A, Orloff LA. Lack of association of BRAF mutation with negative prognostic indicators in papillary thyroid carcinoma: the University of California, San Francisco, experience. JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11):1164-70. PMID: 24030686.
      View in: PubMed
    24. Handorf CR, Kulkarni A, Grenert J, Weiss LM, Rogers WM, Kim OS, Monzon FA, Halks-Miller M, Anderson GG, Walker MG, Pillai R, Henner WD. A multicenter study directly comparing the diagnostic accuracy of gene expression profiling and immunohistochemistry for primary site identification in metastatic tumors. Am J Surg Pathol. 2013 Jul; 37(7):1067-75. PMID: 23648464.
      View in: PubMed
    25. Reis GF, Bloomer MM, Perry A, Phillips JJ, Grenert J, Karnezis AN, Tihan T. Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system. Mod Pathol. 2013 Oct; 26(10):1279-87. PMID: 23702730.
      View in: PubMed
    26. Siao D, Thoeni R, Grenert J, Day LW. A rare presentation of abdominal pain: idiopathic mesenteric phlebosclerosis. Am J Gastroenterol. 2012 Nov; 107(11):1759-60. PMID: 23160302.
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    27. Evason KJ, Grenert J, Ferrell LD, Kakar S. Atypical hepatocellular adenoma-like neoplasms with ß-catenin activation show cytogenetic alterations similar to well-differentiated hepatocellular carcinomas. Hum Pathol. 2013 May; 44(5):750-8. PMID: 23084586.
      View in: PubMed
    28. Aysal A, Karnezis A, Medhi I, Grenert J, Zaloudek CJ, Rabban JT. Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability. Am J Surg Pathol. 2012 Feb; 36(2):163-72. PMID: 22189970.
      View in: PubMed
    29. Grenert J, Smith A, Ruan W, Pillai R, Wu AH. Gene expression profiling from formalin-fixed, paraffin-embedded tissue for tumor diagnosis. Clin Chim Acta. 2011 Jul 15; 412(15-16):1462-4. PMID: 21497155.
      View in: PubMed
    30. Soon RK, Yan JS, Grenert J, Maher JJ. Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology. 2010 Nov; 139(5):1730-9, 1739.e1. PMID: 20682321; PMCID: PMC2967598.
      View in: PubMed, PubMed Central
    31. Pickens MK, Ogata H, Soon RK, Grenert J, Maher JJ. Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet. Liver Int. 2010 Sep; 30(8):1229-39. PMID: 20536716; PMCID: PMC3592570.
      View in: PubMed, PubMed Central
    32. Shah S, Sanford UR, Vargas JC, Xu H, Groen A, Paulusma CC, Grenert J, Pawlikowska L, Sen S, Elferink RP, Bull LN. Strain background modifies phenotypes in the ATP8B1-deficient mouse. PLoS One. 2010 Feb 01; 5(2):e8984. PMID: 20126555; PMCID: PMC2813882.
      View in: PubMed, PubMed Central
    33. Rabban JT, McAlhany S, Lerwill MF, Grenert J, Zaloudek CJ. PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. Am J Surg Pathol. 2010 Feb; 34(2):137-46. PMID: 20061933.
      View in: PubMed
    34. Shafizadeh N, Grenert J, Sahai V, Kakar S. Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder. Hum Pathol. 2010 Apr; 41(4):485-92. PMID: 20040392.
      View in: PubMed
    35. de Alba Campomanes AG, Rutar T, Crawford JB, Seiff S, Goodman D, Grenert J. Crystal-storing histiocytosis and crystalline keratopathy caused by monoclonal gammopathy of undetermined significance. Cornea. 2009 Oct; 28(9):1081-4. PMID: 19724196.
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    36. Carter JT, Grenert J, Rubenstein L, Stewart L, Way LW. Neuroendocrine tumors of the ampulla of Vater: biological behavior and surgical management. Arch Surg. 2009 Jun; 144(6):527-31. PMID: 19528385.
      View in: PubMed
    37. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert J, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31. PMID: 19375390; PMCID: PMC2800791.
      View in: PubMed, PubMed Central
    38. Pickens MK, Yan JS, Ng RK, Ogata H, Grenert J, Beysen C, Turner SM, Maher JJ. Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis. J Lipid Res. 2009 Oct; 50(10):2072-82. PMID: 19295183; PMCID: PMC2739762.
      View in: PubMed, PubMed Central
    39. Hwang HS, Glastonbury CM, Grenert J, Lustig LR. Expansile bone cyst and cholesteatoma of the temporal bone. Otol Neurotol. 2009 Feb; 30(2):170-3. PMID: 19092715.
      View in: PubMed
    40. Rabban JT, Lerwill MF, McCluggage WG, Grenert J, Zaloudek CJ. Primary ovarian carcinoid tumors may express CDX-2: a potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol. 2009 Jan; 28(1):41-8. PMID: 19047909.
      View in: PubMed
    41. Carter JT, Grenert J, Rubenstein L, Stewart L, Way LW. Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg. 2008 Aug; 207(2):210-8. PMID: 18656049.
      View in: PubMed
    42. Somsouk M, Shergill AK, Grenert J, Harris H, Cello JP, Shah JN. Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA. Gastrointest Endosc. 2008 Jul; 68(1):186-7. PMID: 18291393.
      View in: PubMed
    43. Kanwar B, Gao DW, Hwang AB, Grenert J, Williams SP, Franc B, McCune JM. In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis. J Immunol Methods. 2008 Jan 01; 329(1-2):21-30. PMID: 17964595; PMCID: PMC2683264.
      View in: PubMed, PubMed Central
    44. Modica R, Emery H, Lam W, Hermiston M, Grenert J, Wirt M, von Scheven E. Epstein-Barr virus-associated B cell lymphoproliferative disease in a child with neonatal-onset multisystem inflammatory disease. Arthritis Rheum. 2006 Oct 15; 55(5):823-5. PMID: 17013844.
      View in: PubMed
    45. Rajpal S, Warren RS, Alexander M, Yeh BM, Grenert J, Hintzen S, Ljung BM, Bergsland EK. Pancreatoblastoma in an adult: case report and review of the literature. J Gastrointest Surg. 2006 Jun; 10(6):829-36. PMID: 16769539.
      View in: PubMed
    46. Bitton A, Etzell J, Grenert J, Wang E. Erythrophagocytosis in Gaucher cells. Arch Pathol Lab Med. 2004 Oct; 128(10):1191-2. PMID: 15387692.
      View in: PubMed
    47. Grenert J, Johnson BD, Toft DO. The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes. J Biol Chem. 1999 Jun 18; 274(25):17525-33. PMID: 10364185.
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    48. Grenert J, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO. The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. J Biol Chem. 1997 Sep 19; 272(38):23843-50. PMID: 9295332.
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    49. Moraghan T, Antoniucci DM, Grenert J, Sieck GC, Johnson C, Miller VM, Fitzpatrick LA. Differential response in cell proliferation to beta estradiol in coronary arterial vascular smooth muscle cells obtained from mature female versus male animals. Endocrinology. 1996 Nov; 137(11):5174-7. PMID: 8895395.
      View in: PubMed
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