Leslie Benet, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address513 Parnassus Avenue, MSB
San Francisco CA 94117
Phone415-476-3853
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1965 Graduate Division (Pharmaceutical Chemistry)
    Collapse Awards and Honors
    American Pharmacists Association Academy of Pharmaceutical Research and Science (APhA-APRS),20132013 APhA-APRS Ebert Prize
    American Association of Pharmaceutical Scientists2013AAPS Journal Manuscript Award for the Most Outstanding Manuscript
    International Pharmaceutical Federation, The Netherlands2012Honorary Member
    University of Michigan2011Doctor of Science, honoris causa
    National Research Council 2011Named “National Associate”
    American College of Clinical Pharmacology, 40th Annual Meeting, Chicago, IL 2011Distinguished Investigator Award
    Controlled Release Society 2010Elected Fellow
    Catholic University of Leuven, Leuven, Belgium 2010Doctor of Philosophy, honoris causa
    American Society for Clinical Pharmacology and Therapeutics 111th Annual Meeting, Atlanta, Georgia 2010Oscar B. Hunter Memorial Award in Therapeutics
    100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich, Nürnberg, Germany2008Paul Ehrlich Magic-Bullet Award 2008 Lifetime Achievement
    University of California San Francisco2007UCSF 7th Distinguished Clinical Research Lecturer
    Institute for Scientific Information2003ISI Highly Cited Researcher
    of Medical Countermeasures Against Biological Warfare Agents 2002  - 2004Chair, IOM/NRC Committee on Accelerating the Research, Development and Acquisition
    International Pharmaceutical Federation2001Høst-Madsen Medal
    Sichuan University, Sichuan Province, China2014  - 2019Guest Professorship
    Zhengzhou University, Henan Province, China2012Visiting Professor of the First Clinical Medical College of Zhengzhou University, and the Institute
    University of Wisconsin2013Busse Lecture
    NRPB – AAPS Workshop on Clinical and Diagnostic Biomarkers, Taipei, Taiwan2012Invited Keynote Lecture
    Texas Tech University Health Science Center School of Pharmacy Research Days, Texas Tech University2012Invited Keynote Lecture
    Chinese Society of Clinical Pharmacy, Zhengzhou, China2012Honorary Member
    CPSA Shanghai 2012: From Bench to Decision Making – From Basics to Applications, Shanghai, China 2012Invited Plenary Lecture
    International Symposium on Past, Present and Future Molecular Pharmacokinetics, Tokyo, Japan 2012Invited Plenary Lecture
    Horace Rackham School of Graduate Studies, University of Michigan2011Inaugural Albert B. Prescott Distinguished Lecture
    State University of New York at Buffalo2011Gerhard Levy Distinguished Lectureship in Pharmaceutical Sciences
    Biomedical Centre, Uppsala University, Uppsala, Sweden 2011Invited Plenary Lecture, Symposium
    AstraZeneca Research & Development Mölndal, Sweden 2011The AstraZeneca Drug Hunting Lecture
    Thompson Reuters Highly Cited Researcher20141 of 16 pharmacologists worldwide to be listed in both 2001 and 2014 compilations
    2010 Pharmaceutical Sciences World Congress and the AAPS Annual Meeting and Exposition, New Orleans,2010Invited Plenary Lecture
    The 42nd Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), The Ohio State University2010Invited Keynote Lecture
    18th International Symposium on Microsomes and Drug Oxidations, Beijing, China 2010Invited Plenary Lecture
    129th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Japan 2009Invited Plenary Lecture
    University of Athens, Greece 2005Doctor of Philosophy, honoris causa
    9th International Symposium of the Controlled Release Society Indian Chapter, Mumbai, India2009Invited Plenary Lecture
    100th Anniversary of School of Pharmacy, NDMC; 2008 PST & TSHP Joint International Conference2008Invited Keynote Speaker
    2008National Defense Medical Center, Taipei
    2008Nagai Foundation Tokyo Distinguished Lectureship 2008
    28th Annual Meeting of the Japanese Society for Drug Delivery Systems, Tokyo, Japan2008Invited Plenary Lecture
    Modified Release Forum, West Point, PA 2008Invited Plenary Lecture
    109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics2008Invited Featured Speaker
    iMED.UL (Research Institute for Medicines and Pharmaceutical Sciences) University of Lisbon, Portuga2008Chair, Scientific Advisory Board
    8th International Symposium on Advances in Technology & Business Potential of New Drug Delivery Syst2008Keynote Lecture
    Japan Society for the Study of Xenobiotics, Sendai, Japan 2007International Honorary Member
    University of Michigan College of Pharmacy, Ann Arbor, MI 2007Graduation Speaker
    Division of Biocomputing, School of Medicine, University of New Mexico2007Keynote Lecture, Biocomputing Day
    Meeting of the European Drug Absorption Network, Leuven, Belgium 2007Keynote Lecture
    7th International Symposium on Advances in Technology and Business Potential of New Drug Delivery Sy2007Plenary Lecture
    4th International COE Symposium, Target Validation, Lead Optimization & Clinical Development, Tokyo2006Plenary Lecture
    16th International Symposium on Microsomes and Drug Oxidation, Budapest2006Plenary Lecture
    Gordon Research Conference on Drug Metabolism, Plymouth, NH 2006Chair
    Great Lakes Symposium 2006, Buffalo, NY 2006Keynote Address
    Journees Galeniques de Saint-Remy de Provence, Saint-Remy, France 2006Plenary Lecture
    Canadian Society for Pharmaceutical Sciences 9th Annual International Symposium on Pharmaceutical Sc2006Plenary Lecture
    Analytica Conference 2006, Munich, Germany 2006Plenary Lecture
    British Pharmaceutical Conference, Manchester, UK 2005Keynote Address
    2nd International Symposium on Scientific & Regulatory Aspects of Dissolution & Bioequivalence2005Plenary Lecture
    9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology2005Plenary Lecture
    Controlled Release Society 2004 Annual Meeting & Exposition2004Career Achievement Award in Oral Drug Delivery
    Pharmaceutical Sciences World Congress 2004, Kyoto2004Research Achievement Award in Pharmaceutical Sciences
    Romanian Academy of Medical Sciences2003Invested as a “Member of Honour”
    First Congress of the Portuguese Society for Pharmaceutical Sciences2003Opening Plenary Lecture
    International Pharmaceutical Technology Symposium 2002, Istanbul, Turkey 2002Plenary Lecture
    Academia de Ciencias Farmacéuticas de Chile, Santiago, Chile 2002Invested as a “Miembro Honorario”
    10th International Conference on Pharmaceutical Technology, Florence, Italy 2002Plenary Lecture
    American Association of Indian Pharmaceutical Scientists2001Elected Fellow
    FDA/CDER and ASCPT2015William B. Abrams Lectureship
    Medical Technology Schools2015Listed among "25 Top Pharmacy Professors" in the U.S.A.
    Thomson Reuters2014Highly cited Researcher-Pharmacology
    Medical Technology Schools2015"25 Top Pharmacy Professors" in USA
    FDA/CDER and American Society for Clinical Pharmacology and Therapeutics2015William B. Abrams Lectureship
    International Society for the Study of Xenobiotics2015North American Scientific Achievement Award
    American Pharmacists Association2016Remington Honor Medal
    University of Lisbon, Portugal2016Doctor of Philosophy, honoris causa

    Collapse Overview 
    Collapse Overview
    Dr. Benet, Professor and former Chairman (1978-1998), Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, received his A.B. (English), B.S. (Pharmacy), M.S. from the University of Michigan and Ph.D. from the University of California. He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and Universidade de Lisboa, Lisbon, Portugal (Ph.D., 2016). His research interests, more than 570 publications, 6 books and 11 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Thompson Reuters as one of the most highly cited pharmacologists worldwide, with his published peer-reviewed papers cited more than 20,000 times. His most recent work has addressed the interplay of metabolic enzymes and transport proteins as related to oral bioavailability and hepatic elimination, and the development of the Biopharmaceutics Drug Disposition Classification System (BDDCS). Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY, CHEMICAL AND PHARMACEUTICAL BULLETIN, AAPS JOURNAL and ARCHIVES OF DRUG INFORMATION. He is a Fellow of the Academy of Pharmaceutical Sciences and Research, the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP), the Controlled Release Society (CRS) and the American Association for the Advancement of Science. In 1982, Dr. Benet received the American Pharmacists Association (APhA) Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the Institute of Medicine (IOM) of the National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the initial AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) and delivered the American College of Clinical Pharmacy “Therapeutic Frontiers Lecture”. In 1996, he received the AAPS Distinguished Service Award, and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award. In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer and is still the only non-MD so honored. In 2010, he received the ASCPT Hunter Memorial Award in Therapeutics and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor under the title “50 Years of Scientific Excellence and Still Going Strong” and he was made an honorary member of FIP. In March 2013, he was awarded the APhA Ebert Prize and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated IOM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and as a member of the FDA Generic Drugs Advisory Committee, the FDA Science Board and the NRC Biodefense Standing Committee. From 2007-2012 he served as Chair of the FIP Foundation for Education and Research. He presently serves on the Boards of Directors of the American Foundation for Pharmaceutical Education, Impax Laboratories, and Medicines360, of which the latter, he chairs. SEPTEMBER 2013
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    Collapse Research 
    Collapse Research Activities and Funding
    A novel mechanistic modeling platform for predicting drug clearance and disposition mediated by transporters and enzymes
    NIH R43GM113597Jan 15, 2015 - Oct 14, 2015
    Role: Co-Principal Investigator
    A Transporter-Based Predictive ADME Platform
    NIH R43RR031474May 15, 2010 - May 14, 2011
    Role: Principal Investigator
    Transporter-Enzyme Interplay Evaluation via Microfluidiic HTS Cell Culture Device
    NIH R21GM075900Jun 2, 2006 - May 31, 2009
    Role: Principal Investigator
    GENDER EFFECTS ON HIV BIOLOGY
    NIH P01HD040543Apr 23, 2001 - Mar 31, 2008
    Role: Co-Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH P01CA072006Jun 10, 1997 - Jun 30, 2010
    Role: Co-Investigator
    ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    NIH R01GM036633Apr 1, 1986 - Mar 31, 2004
    Role: Principal Investigator
    SCIENTIFIC REVIEW AND EVALUATION AWARD - PHARMACOLOGICAL
    NIH U09GM007709Nov 1, 1984 - Jul 31, 1991
    Role: Co-Principal Investigator
    NITROGLYCERIN DINITRATE METABOLITES--KINETICS/DYNAMICS
    NIH R01HL032243Apr 1, 1984 - Dec 31, 1991
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Can In Vitro In Vivo Extrapolation (IVIVE) Be Successful? Recognizing the Incorrect Clearance Assumptions. Clin Pharmacol Ther. 2021 Nov 03. Benet LZ, Sodhi JK. PMID: 34731496.
      View in: PubMed   Mentions:
    2. Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies. Pharm Res. 2021 Oct; 38(10):1639-1644. Liu S, Sodhi JK, Benet LZ. PMID: 34729703.
      View in: PubMed   Mentions:
    3. Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing. AAPS PharmSciTech. 2021 Aug 19; 22(7):224. Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ. PMID: 34410534.
      View in: PubMed   Mentions: 1     Fields:    
    4. Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharm Res. 2021 Jul; 38(7):1139-1156. Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. PMID: 34254223.
      View in: PubMed   Mentions:    Fields:    
    5. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clin Pharmacol Ther. 2021 08; 110(2):480-485. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. PMID: 33880760.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions. AAPS J. 2021 05 10; 23(3):67. Benet LZ, Sodhi JK, Makrygiorgos G, Mesbah A. PMID: 33973074.
      View in: PubMed   Mentions:    Fields:    
    7. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug Test Anal. 2021 Jul; 13(7):1354-1370. Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. PMID: 33742745.
      View in: PubMed   Mentions: 1  
    8. Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption. Pharm Res. 2021 May; 38(5):795-801. Kou W, Sodhi JK, Wu X, Benet LZ. PMID: 33847849.
      View in: PubMed   Mentions:    Fields:    
    9. Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing. J Clin Pharmacol. 2021 06; 61(6):734-735. Benet LZ. PMID: 33742720.
      View in: PubMed   Mentions:    Fields:    
    10. Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. J Med Chem. 2021 04 08; 64(7):3546-3559. Sodhi JK, Benet LZ. PMID: 33765384.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clin Pharmacokinet. 2021 02; 60(2):205-222. Sodhi JK, Huang CH, Benet LZ. PMID: 32725383.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. Pharm Res. 2020 Sep 29; 37(10):208. Sodhi JK, Liu S, Benet LZ. PMID: 32996065.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem. 2020 10 19; 15(20):1862-1874. Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K. PMID: 32743945.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. AAPS J. 2020 09 10; 22(5):120. Benet LZ, Sodhi JK. PMID: 32914238.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. AAPS J. 2020 08 17; 22(5):111. Sodhi JK, Benet LZ. PMID: 32808084.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clin Pharmacol Ther. 2020 08; 108(2):306-315. Sodhi JK, Benet LZ. PMID: 32150643.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Drug Metab Dispos. 2020 07; 48(7):537-543. Sodhi JK, Wang HJ, Benet LZ. PMID: 32305951.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System. Pharmacotherapy. 2020 04; 40(4):274-290. Liu W, Yan T, Chen K, Yang L, Benet LZ, Zhai S. PMID: 32100890.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions. Pharm Res. 2020 Mar 25; 37(4):73. Sodhi JK, Liu S, Benet LZ. PMID: 32215750.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology. 2020; 105(3-4):145-163. Sun A, Benet LZ. PMID: 31910414.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    21. Can BDDCS illuminate targets in drug design? Drug Discov Today. 2019 12; 24(12):2299-2306. Bocci G, Benet LZ, Oprea TI. PMID: 31585170.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    22. Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation. Drug Metab Dispos. 2019 12; 47(12):1397-1402. Wang HJ, Benet LZ. PMID: 31563869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug Metab Dispos. 2019 12; 47(12):1368-1371. Bowman CM, Benet LZ. PMID: 31551322.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharm Res. 2019 Sep 04; 36(11):155. Surofchy DD, Frassetto LA, Benet LZ. PMID: 31485804.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. How Transporters Have Changed Basic Pharmacokinetic Understanding. AAPS J. 2019 09 03; 21(6):103. Benet LZ, Bowman CM, Sodhi JK. PMID: 31482335.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    26. The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats. Drug Metab Dispos. 2019 09; 47(9):1004-1012. Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. PMID: 31201213.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    27. Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharm Res. 2019 May 31; 36(8):113. Bowman CM, Benet LZ. PMID: 31152241.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. J Pharmacokinet Pharmacodyn. 2019 04; 46(2):155-163. Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. PMID: 30911879.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction. J Pharm Sci. 2019 07; 108(7):2500-2504. Bowman CM, Benet LZ. PMID: 30817922.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Characterization of Fasiglifam-Related Liver Toxicity in Dogs. Drug Metab Dispos. 2019 05; 47(5):525-534. Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. PMID: 30765394.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug Metab Dispos. 2019 04; 47(4):358-363. Bowman CM, Okochi H, Benet LZ. PMID: 30674616.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 02; 105(2):411-416. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. PMID: 30652304.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    33. Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clin Pharmacol Ther. 2019 02; 105(2):326-328. Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E. PMID: 30652313.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharm Res. 2018 Oct 22; 35(12):242. Benet LZ, Bowman CM, Liu S, Sodhi JK. PMID: 30349948.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    36. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox Biol. 2019 01; 20:349-353. Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. PMID: 30391827.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    37. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine. 2018 Aug-Sep; 2-3:22-28. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. PMID: 30906930.
      View in: PubMed   Mentions: 21  
    38. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. Eur J Pharm Sci. 2018 Oct 15; 123:502-514. Bowman CM, Benet LZ. PMID: 30098391.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification. Toxicol Res (Camb). 2018 May 08; 7(3):358-370. Chan R, Benet LZ. PMID: 29785262.
      View in: PubMed   Mentions: 3  
    40. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. J Clin Pharmacol. 2018 Aug; 58(8):979-989. Benet LZ. PMID: 29663413.
      View in: PubMed   Mentions: 2     Fields:    
    41. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Toxicol Sci. 2018 04 01; 162(2):499-508. Chan R, Benet LZ. PMID: 29272540.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clin Ther. 2018 04; 40(4):660-662. Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. PMID: 29551534.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2018 Mar 15; 32(5):431-441. Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. PMID: 29315954.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. AAPS J. 2018 03 13; 20(3):46. Parasrampuria DA, Benet LZ, Sharma A. PMID: 29536211.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    45. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Sci Rep. 2018 01 08; 8(1):92. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. PMID: 29311658.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    46. Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States. Clin Infect Dis. 2018 01 06; 66(2):213-219. Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. PMID: 29020194.
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    47. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2018 03; 103(3):521-525. Benet LZ, Liu S, Wolfe AR. PMID: 28762489.
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    48. Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide". Clin Transl Sci. 2017 07; 10(4):240-241. Morrissey KM, Benet LZ, Ware JA. PMID: 28664655.
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    49. Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics. J Pharm Sci. 2017 09; 106(9):2231-2233. Benet LZ, Wu HF. PMID: 28502797.
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    50. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 09; 106(9):2895-2898. Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. PMID: 28385546.
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    51. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. PMID: 28385543.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    52. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chem Res Toxicol. 2017 04 17; 30(4):1017-1029. Chan R, Benet LZ. PMID: 28257576.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    53. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS Res Hum Retroviruses. 2017 08; 33(8):778-783. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. PMID: 28253024.
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    54. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. PMID: 28028768.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chin J Nat Med. 2016 Dec; 14(12):888-897. Li J, Larregieu CA, Benet LZ. PMID: 28262115.
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    56. Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial. Clin Pharmacol Ther. 2017 03; 101(3):331-340. Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B. PMID: 27727445.
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    57. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV. 2016 11; 3(11):e521-e528. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. PMID: 27658870.
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    58. Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System. Drug Metab Dispos. 2016 11; 44(11):1731-1735. Bowman CM, Benet LZ, Bowman CM, Benet LZ. PMID: 27519549.
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    59. 2016 Remington Honor Medal Address: Science for the profession. J Am Pharm Assoc (2003). 2016 Jul-Aug; 56(4):365-8. Benet LZ. PMID: 27450136.
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    60. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Int J Tuberc Lung Dis. 2016 06; 20(6):844-7. Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M, Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. PMID: 27155191; PMCID: PMC4889729.
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    61. BDDCS, the Rule of 5 and drugability. Adv Drug Deliv Rev. 2016 06 01; 101:89-98. Benet LZ, Hosey CM, Ursu O, Oprea TI. PMID: 27182629.
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    62. Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial. Clin Pharmacol Ther. 2016 Sep; 100(3):223-31. Burmeister Getz E, Carroll KJ, Jones B, Benet LZ, Burmeister Getz E, Carroll KJ, Jones B, Benet LZ. PMID: 27037630; PMCID: PMC5102576.
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    63. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. AAPS J. 2016 05; 18(3):757-66. Chan R, Wei CY, Chen YT, Benet LZ, Chan R, Wei CY, Chen YT, Benet LZ. PMID: 26951484; PMCID: PMC5256615.
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    64. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clin Pharmacokinet. 2016 Feb; 55(2):143-67. Zheng Y, Chen X, Benet LZ, Zheng Y, Chen X, Benet LZ. PMID: 26293617; PMCID: PMC5674979.
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    65. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. AAPS J. 2016 Jan; 18(1):251-60. Hosey CM, Chan R, Benet LZ, Hosey CM, Chan R, Benet LZ. PMID: 26589308; PMCID: PMC4706282.
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    66. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. J Pharm Sci. 2015 Sep; 104(9):3229-35. Garrison KL, Sahin S, Benet LZ, Garrison KL, Sahin S, Benet LZ. PMID: 26010239; PMCID: PMC4536115.
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    67. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Mol Pharm. 2015 May 04; 12(5):1456-66. Hosey CM, Benet LZ, Hosey CM, Benet LZ. PMID: 25816851; PMCID: PMC4666302.
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    68. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharm Res. 2015 Aug; 32(8):2516-26. Zheng Y, Benet LZ, Okochi H, Chen X, Zheng Y, Benet LZ, Okochi H, Chen X. PMID: 25690341; PMCID: PMC4891189.
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    69. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG, Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. PMID: 25776193.
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    70. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Basic Clin Pharmacol Toxicol. 2015 Jul; 117(1):44-51. Parasrampuria DA, Benet LZ, Parasrampuria DA, Benet LZ. PMID: 25406995.
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    71. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA, Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. PMID: 25274610; PMCID: PMC4389759.
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    72. Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J. 2014 Sep; 16(5):1085-96. Hosey CM, Broccatelli F, Benet LZ, Hosey CM, Broccatelli F, Benet LZ. PMID: 25004821; PMCID: PMC4147063.
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    73. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Mol Pharm. 2014 Apr 07; 11(4):1335-44. Larregieu CA, Benet LZ, Larregieu CA, Benet LZ. PMID: 24628254; PMCID: PMC3983369.
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    74. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ, Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. PMID: 24389906; PMCID: PMC4018220.
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    75. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S, Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. PMID: 24572354; PMCID: PMC4161230.
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    76. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Mol Pharm. 2013 Nov 04; 10(11):4055-62. Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA, Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. PMID: 24044612.
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    77. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Mol Pharm. 2013 Nov 04; 10(11):4038-45. Estudante M, Maya M, Morais JG, Soveral G, Benet LZ, Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. PMID: 24044638.
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    78. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L, Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. PMID: 24030928; PMCID: PMC4018225.
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    79. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 04; 10(11):4032-7. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ, Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. PMID: 23980906; PMCID: PMC3946491.
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    80. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metab Dispos. 2013 Nov; 41(11):1923-33. Horng H, Benet LZ, Horng H, Benet LZ. PMID: 23975029; PMCID: PMC3807055.
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    81. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chem Res Toxicol. 2013 Mar 18; 26(3):465-76. Horng H, Benet LZ, Horng H, Benet LZ. PMID: 23402341; PMCID: PMC3626286.
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    82. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB, Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. PMID: 23417511; PMCID: PMC3640342.
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    83. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. AAPS J. 2013 Apr; 15(2):483-97. Larregieu CA, Benet LZ, Larregieu CA, Benet LZ. PMID: 23344793; PMCID: PMC3675726.
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    84. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci. 2013 Jan; 102(1):34-42. Benet LZ, Benet LZ. PMID: 23147500; PMCID: PMC3684558.
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    85. A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates. Clin Pharmacol Ther. 2012 Nov; 92(5):551-2. Benet LZ, Benet LZ. PMID: 23085879.
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    86. Intestinal drug transporters: an overview. Adv Drug Deliv Rev. 2013 Oct; 65(10):1340-56. Estudante M, Morais JG, Soveral G, Benet LZ, Estudante M, Morais JG, Soveral G, Benet LZ. PMID: 23041352.
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    87. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy? Clin Pharmacol Ther. 2012 Aug; 92(2):203-13. Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA, Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. PMID: 22739140.
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    88. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. AAPS J. 2012 Jun; 14(2):164-7. Benet LZ, Benet LZ. PMID: 22302585; PMCID: PMC3326156.
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    89. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharm Res. 2012 Jul; 29(7):1768-74. Liu W, Okochi H, Benet LZ, Zhai SD, Liu W, Okochi H, Benet LZ, Zhai SD. PMID: 22350803; PMCID: PMC4167886.
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    90. BDDCS class prediction for new molecular entities. Mol Pharm. 2012 Mar 05; 9(3):570-80. Broccatelli F, Cruciani G, Benet LZ, Oprea TI, Broccatelli F, Cruciani G, Benet LZ, Oprea TI. PMID: 22224483; PMCID: PMC3295927.
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    91. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan; 64(1):95-109. Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ, Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. PMID: 22261306; PMCID: PMC3496430.
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    92. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Pharmacotherapy. 2011 Sep; 31(9):871-6. Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL, Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. PMID: 21923588; PMCID: PMC3727161.
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    93. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metab Dispos. 2011 Nov; 39(11):2017-9. Grover A, Frassetto LA, Benet LZ, Chakkera HA, Grover A, Frassetto LA, Benet LZ, Chakkera HA. PMID: 21849516; PMCID: PMC3198899.
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    94. BDDCS applied to over 900 drugs. AAPS J. 2011 Dec; 13(4):519-47. Benet LZ, Broccatelli F, Oprea TI, Benet LZ, Broccatelli F, Oprea TI. PMID: 21818695; PMCID: PMC3231854.
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    95. Lead PK commentary: predicting human pharmacokinetics. J Pharm Sci. 2011 Oct; 100(10):4047-9. Rowland M, Benet LZ, Rowland M, Benet LZ. PMID: 21630278.
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    96. Professor Akira Tsuji: scientist, educator, and leader. J Pharm Sci. 2011 Sep; 100(9):3541-6. Terasaki T, Sugiyama Y, Benet LZ, Terasaki T, Sugiyama Y, Benet LZ. PMID: 21630279.
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    97. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. J Pharm Sci. 2011 Sep; 100(9):3831-42. Reyes M, Benet LZ, Reyes M, Benet LZ. PMID: 21618544; PMCID: PMC3581075.
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    98. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. J Pharmacokinet Pharmacodyn. 2011 Jun; 38(3):369-83. Grover A, Benet LZ, Grover A, Benet LZ. PMID: 21499748; PMCID: PMC3677834.
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    99. The BCS, BDDCS, and regulatory guidances. Pharm Res. 2011 Jul; 28(7):1774-8. Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX, Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. PMID: 21491148.
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    100. Is Ciprofloxacin a Substrate of P-glycoprotein? Arch Drug Inf. 2011 Mar; 4(1):1-9. Park MS, Okochi H, Benet LZ, Park MS, Okochi H, Benet LZ. PMID: 21572514; PMCID: PMC3084506.
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    101. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):525-7. Aarons L, Benet LZ, Aarons L, Benet LZ. PMID: 21069561.
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    102. Clearance (née Rowland) concepts: a downdate and an update. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):529-39. Benet LZ, Benet LZ. PMID: 21113650; PMCID: PMC3005114.
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    103. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ, Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. PMID: 21075140.
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    104. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Clin Pharmacol Ther. 2010 Oct; 88(4):540-7. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ, Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. PMID: 20703222; PMCID: PMC3091944.
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    105. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clin Pharmacol Ther. 2010 Sep; 88(3):405-7. Benet LZ, Larregieu CA, Benet LZ, Larregieu CA. PMID: 20668447; PMCID: PMC4169211.
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    106. Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar; 9(3):215-36. International Transporter Consortium , Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L, International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. PMID: 20190787; PMCID: PMC3326076.
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    107. Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation. Clin Ther. 2010 Mar; 32(3):534-42. Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B, Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B. PMID: 20399990; PMCID: PMC3097025.
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    108. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Clin Pharmacol Ther. 2010 Apr; 87(4):465-72. Sun H, Frassetto LA, Huang Y, Benet LZ, Sun H, Frassetto LA, Huang Y, Benet LZ. PMID: 20090676; PMCID: PMC3581054.
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    109. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metab Dispos. 2010 Jan; 38(1):133-42. Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ, Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. PMID: 19786506; PMCID: PMC2802421.
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    111. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. J Pharm Sci. 2009 Nov; 98(11):4413-9. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, de Souza J, Benet LZ, Huang Y, Storpirtis S. PMID: 19472342.
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    112. The drug transporter-metabolism alliance: uncovering and defining the interplay. Mol Pharm. 2009 Nov-Dec; 6(6):1631-43. Benet LZ, Benet LZ. PMID: 19874004; PMCID: PMC2796475.
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    115. Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate. Pediatr Infect Dis J. 2009 May; 28(5):398-402. Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ, Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ. PMID: 19295465; PMCID: PMC3101254.
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    116. Effects of drug transporters on volume of distribution. AAPS J. 2009 Jun; 11(2):250-61. Grover A, Benet LZ, Grover A, Benet LZ. PMID: 19399628; PMCID: PMC2691462.
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    117. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. J Acquir Immune Defic Syndr. 2009 Apr 15; 50(5):482-91. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM, Women's Interagency HIV Study , Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM, Women's Interagency HIV Study. PMID: 19408353; PMCID: PMC2700138.
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    118. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Pharm Res. 2008 Dec; 25(12):2869-77. Sahin S, Benet LZ, Sahin S, Benet LZ. PMID: 19015955; PMCID: PMC3581066.
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    119. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther. 2009 Jan; 85(1):78-85. Zheng HX, Huang Y, Frassetto LA, Benet LZ, Zheng HX, Huang Y, Frassetto LA, Benet LZ. PMID: 18843263; PMCID: PMC3582657.
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    120. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2008 Oct 01; 2(5):379-83. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J, Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. PMID: 19745507; PMCID: PMC5385924.
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    121. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol. 2008 Oct; 21(10):1933-8. Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA, Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. PMID: 18693772.
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    122. The use of BDDCS in classifying the permeability of marketed drugs. Pharm Res. 2008 Mar; 25(3):483-8. Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX, Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. PMID: 18236138; PMCID: PMC3580995.
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    123. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metab Dispos. 2008 Apr; 36(4):682-7. Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ, Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. PMID: 18187563.
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    124. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant. 2008 Feb; 8(2):355-65. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG, Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. PMID: 18093266.
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    125. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev. 2008 Mar 17; 60(6):717-33. Custodio JM, Wu CY, Benet LZ, Custodio JM, Wu CY, Benet LZ. PMID: 18199522; PMCID: PMC2292816.
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    126. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ, Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 17949460.
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    127. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. J Mass Spectrom. 2007 Jun; 42(6):793-802. Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U, Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. PMID: 17511017.
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    128. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Clin Pharmacol Ther. 2007 Jun; 81(6):828-32. Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ, Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. PMID: 17361125.
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    129. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Drug Metab Dispos. 2007 May; 35(5):758-64. Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH, Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. PMID: 17303625.
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    130. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther. 2007 Feb; 81(2):194-204. Lau YY, Huang Y, Frassetto L, Benet LZ, Lau YY, Huang Y, Frassetto L, Benet LZ. PMID: 17192770.
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    131. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. J Pharmacol Exp Ther. 2006 Nov; 319(2):864-70. Lam JL, Shugarts SB, Okochi H, Benet LZ, Lam JL, Shugarts SB, Okochi H, Benet LZ. PMID: 16905688.
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    132. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metab Dispos. 2006 Aug; 34(8):1336-44. Lam JL, Okochi H, Huang Y, Benet LZ, Lam JL, Okochi H, Huang Y, Benet LZ. PMID: 16698890.
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    133. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Drug Metab Dispos. 2006 Jul; 34(7):1175-81. Lau YY, Okochi H, Huang Y, Benet LZ, Lau YY, Okochi H, Huang Y, Benet LZ. PMID: 16624870.
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    134. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul; 34(7):1136-44. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET, Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. PMID: 16581945.
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    135. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET, Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. PMID: 16628600.
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    136. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH, Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. PMID: 16304193; PMCID: PMC1315979.
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    137. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chem Res Toxicol. 2005 Nov; 18(11):1729-36. Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ, Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. PMID: 16300382.
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    138. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther. 2006 Feb; 316(2):762-71. Lau YY, Okochi H, Huang Y, Benet LZ, Lau YY, Okochi H, Huang Y, Benet LZ. PMID: 16258024.
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    139. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Mol Pharm. 2005 Sep-Oct; 2(5):428-34. Chang JH, Benet LZ, Chang JH, Benet LZ. PMID: 16196496.
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    140. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006 Jan; 109(1-2):1-11. Sun H, Frassetto L, Benet LZ, Sun H, Frassetto L, Benet LZ. PMID: 16085315.
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    141. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Nephrology (Carlton). 2005 Aug; 10(4):393-9. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L, Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. PMID: 16109088.
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    142. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ, Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 16003227.
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    143. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. J Clin Pharmacol. 2005 Apr; 45(4):411-21. Putnam WS, Woo JM, Huang Y, Benet LZ, Putnam WS, Woo JM, Huang Y, Benet LZ. PMID: 15778422.
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    144. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Mol Interv. 2005 Apr; 5(2):79-83. Benet LZ, Benet LZ. PMID: 15821156.
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    145. Basic pharmacological interactions and how they may impact on one another. . 2005 Mar; 38 Suppl 1:S22-3. Benet L, Benet L. PMID: 15867606.
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    146. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 2005 Jan; 22(1):11-23. Wu CY, Benet LZ, Wu CY, Benet LZ. PMID: 15771225.
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    147. Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Pharm Res. 2005 Jan; 22(1):79-85. Mohri K, Okada K, Benet LZ, Mohri K, Okada K, Benet LZ. PMID: 15771233.
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    148. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metab Dispos. 2004 Nov; 32(11):1311-6. Lam JL, Benet LZ, Lam JL, Benet LZ. PMID: 15483198.
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    149. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit. 2004 Oct; 26(5):546-62. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U, Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. PMID: 15385839.
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    150. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Catheter Cardiovasc Interv. 2004 Oct; 63(2):222-30. Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M, Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. PMID: 15390346.
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    151. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N, Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. PMID: 15339861; PMCID: PMC1575349.
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    152. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov; 32(11):1239-46. Sun H, Huang Y, Frassetto L, Benet LZ, Sun H, Huang Y, Frassetto L, Benet LZ. PMID: 15286055.
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    153. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul; 21(7):1284-93. Kim WY, Benet LZ, Kim WY, Benet LZ. PMID: 15290871.
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    154. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm. 2004 Jun 11; 277(1-2):3-9. Benet LZ, Cummins CL, Wu CY, Benet LZ, Cummins CL, Wu CY. PMID: 15158963.
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    155. Pharmacogenomics and transplantation: where are we? Am J Transplant. 2004 Jun; 4(6):843. Frassetto LA, Benet LZ, Frassetto LA, Benet LZ. PMID: 15147415.
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    156. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107. Serkova NJ, Christians U, Benet LZ, Serkova NJ, Christians U, Benet LZ. PMID: 15087483.
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    157. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther. 2004 Mar; 308(3):1040-5. Lau YY, Wu CY, Okochi H, Benet LZ, Lau YY, Wu CY, Okochi H, Benet LZ. PMID: 14634033.
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    158. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metab Dispos. 2003 Nov; 31(11):1292-5. Wu CY, Benet LZ, Wu CY, Benet LZ. PMID: 14570757.
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    159. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan; 308(1):143-55. Cummins CL, Jacobsen W, Christians U, Benet LZ, Cummins CL, Jacobsen W, Christians U, Benet LZ. PMID: 14569063.
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    160. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab. 2003 Oct; 4(5):393-8. Benet LZ, Cummins CL, Wu CY, Benet LZ, Cummins CL, Wu CY. PMID: 14529371.
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    161. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Drug Metab Dispos. 2003 Jun; 31(6):727-30. Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ, Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. PMID: 12756204.
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    162. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. J Pharmacol Exp Ther. 2003 Apr; 305(1):250-6. Li C, Grillo MP, Benet LZ, Li C, Grillo MP, Benet LZ. PMID: 12649376.
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    163. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther. 2003 Apr; 305(1):306-14. Cummins CL, Salphati L, Reid MJ, Benet LZ, Cummins CL, Salphati L, Reid MJ, Benet LZ. PMID: 12649383.
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    164. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Toxicol Appl Pharmacol. 2003 Mar 01; 187(2):101-9. Li C, Grillo MP, Benet LZ, Li C, Grillo MP, Benet LZ. PMID: 12649042.
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    165. Pharmacokinetics of cyclosporine pre- and post-liver transplantation. J Clin Pharmacol. 2003 Jan; 43(1):38-42. Hebert MF, Wacher VJ, Roberts JP, Benet LZ, Hebert MF, Wacher VJ, Roberts JP, Benet LZ. PMID: 12520626.
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    166. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC, Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. PMID: 15618725.
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    168. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. J Pharm Sci. 2002 Dec; 91(12):2622-35. Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ, Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. PMID: 12434407.
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    172. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J Pharmacol Exp Ther. 2002 Sep; 302(3):1123-8. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N, Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. PMID: 12183671.
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    173. Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells. J Pharm Sci. 2002 Apr; 91(4):1169-77. Flanagan SD, Takahashi LH, Liu X, Benet LZ, Flanagan SD, Takahashi LH, Liu X, Benet LZ. PMID: 11948555.
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    174. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res. 2002 Apr; 19(4):457-62. Susanto M, Benet LZ, Susanto M, Benet LZ. PMID: 12033380.
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    177. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. J Clin Pharmacol. 2002 Mar; 42(3):304-11. Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ, Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. PMID: 11865967.
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    179. Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 15; 767(2):245-53. Unger M, Jacobsen W, Holzgrabe U, Benet LZ, Unger M, Jacobsen W, Holzgrabe U, Benet LZ. PMID: 11885853.
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    180. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet. 2002; 41(11):813-51. Christians U, Jacobsen W, Benet LZ, Lampen A, Christians U, Jacobsen W, Benet LZ, Lampen A. PMID: 12190331.
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    181. Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro. Drug Metab Dispos. 2002 Jan; 30(1):55-62. Grillo MP, Benet LZ, Grillo MP, Benet LZ. PMID: 11744612.
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    182. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002; 64(3):126-34. Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ, Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. PMID: 11834888.
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    183. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharm Res. 2002 Jan; 19(1):27-33. Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ, Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. PMID: 11837697.
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    184. Red wine decreases cyclosporine bioavailability. Clin Pharmacol Ther. 2001 Nov; 70(5):462-7. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A, Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. PMID: 11719733.
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    186. Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats. Drug Metab Dispos. 2001 Sep; 29(9):1210-5. Grillo MP, Chiellini G, Tonelli M, Benet LZ, Grillo MP, Chiellini G, Tonelli M, Benet LZ. PMID: 11502730.
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    187. Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol. 2001 Aug; 14(8):1033-40. Grillo MP, Benet LZ, Grillo MP, Benet LZ. PMID: 11511177.
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    188. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res. 2001 Aug; 18(8):1102-9. Cummins CL, Mangravite LM, Benet LZ, Cummins CL, Mangravite LM, Benet LZ. PMID: 11587480.
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    198. Chiral bioequivalence: effect of absorption rate on racemic etodolac. Clin Pharmacokinet. 2000 Dec; 39(6):459-69. Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ, Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ. PMID: 11192477.
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    200. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov; 28(11):1343-51. Jacobsen W, Christians U, Benet LZ, Jacobsen W, Christians U, Benet LZ. PMID: 11038163.
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    203. Recommendations for bioequivalence testing of cyclosporine generics revisited. Ther Drug Monit. 2000 Jun; 22(3):330-45. Christians U, First MR, Benet LZ, Christians U, First MR, Benet LZ. PMID: 10850403.
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    204. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar; 129(6):1235-43. Soldner A, Benet LZ, Mutschler E, Christians U, Soldner A, Benet LZ, Mutschler E, Christians U. PMID: 10725273; PMCID: PMC1571937.
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    215. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr; 16(4):478-85. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ, Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. PMID: 10227700.
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    253. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica. 1996 Apr; 26(4):381-94. Berg-Candolfi M, Candolfi E, Benet LZ, Berg-Candolfi M, Candolfi E, Benet LZ. PMID: 9173679.
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    255. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica. 1996 Mar; 26(3):275-84. Jaeger W, Benet LZ, Bornheim LM, Jaeger W, Benet LZ, Bornheim LM. PMID: 8730919.
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    261. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct; 23(10):1099-103. Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ, Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ. PMID: 8654198.
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    262. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos. 1995 Sep; 23(9):900-3. Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ, Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ. PMID: 8565778.
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    264. Gender effects in pharmacokinetics and pharmacodynamics. Drugs. 1995 Aug; 50(2):222-39. Harris RZ, Benet LZ, Schwartz JB, Harris RZ, Benet LZ, Schwartz JB. PMID: 8521756.
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    266. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995 Jul; 13(3):129-34. Wacher VJ, Wu CY, Benet LZ, Wacher VJ, Wu CY, Benet LZ. PMID: 7619215.
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    267. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther. 1995 Jul; 58(1):15-9. Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ, Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. PMID: 7628178.
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    269. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharm Drug Dispos. 1995 May; 16(4):303-12. Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ, Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. PMID: 7548779.
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    270. 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 07; 666(1):45-53. Haj-Yehia AI, Benet LZ, Haj-Yehia AI, Benet LZ. PMID: 7655620.
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    276. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nat Med. 1995 Jan; 1(1):2-4. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ, Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. PMID: 7584944.
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    281. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharm Res. 1994 Jun; 11(6):844-7. Perotti BY, Prueksaritanont T, Benet LZ, Perotti BY, Prueksaritanont T, Benet LZ. PMID: 7524055.
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    287. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. J Clin Pharmacol. 1994 Jan; 34(1):60-7. Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ, Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. PMID: 8132853.
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    288. Pharmacokinetics--a relevant factor for the choice of a drug? Aliment Pharmacol Ther. 1994; 8 Suppl 1:25-32. Benet LZ, Zech K, Benet LZ, Zech K. PMID: 8180291.
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    293. Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers. J Pharmacokinet Biopharm. 1993 Oct; 21(5):515-32. Gumbleton M, Benet LZ, Gumbleton M, Benet LZ. PMID: 8145129.
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    327. Stereoselective disposition of ketoprofen in rats. Drug Metab Dispos. 1991 May-Jun; 19(3):717-8. Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET, Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET. PMID: 1680643.
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    328. Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist. DICP. 1991 Apr; 25(4):427-30. Benet LZ, Benet LZ. PMID: 1926916.
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    387. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives. Clin Pharmacol Ther. 1986 Apr; 39(4):425-9. Legler UF, Benet LZ, Legler UF, Benet LZ. PMID: 3956058.
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    393. The macromolecular binding of prednisone in plasma of healthy volunteers including pregnant women and oral contraceptive users. J Pharmacokinet Biopharm. 1985 Dec; 13(6):561-9. Gustavson LE, Benet LZ, Gustavson LE, Benet LZ. PMID: 3834071.
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    398. Peptides and proteins as drugs. Pharm Res. 1985 Jul; 2(4):151-6. Ferraiolo BL, Benet LZ, Ferraiolo BL, Benet LZ. PMID: 24272804.
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    400. Pharmacokinetics and metabolism of bepridil. Am J Cardiol. 1985 Mar 15; 55(7):8C-13C. Benet LZ, Benet LZ. PMID: 3872057.
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    403. Immunosuppressive activity of prednisone and prednisolone and their metabolic interconversion in the mixed lymphocyte reaction. Int J Immunopharmacol. 1985; 7(5):731-7. Tsang SY, Garovoy MR, Benet LZ, Tsang SY, Garovoy MR, Benet LZ. PMID: 2931388.
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    405. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. J Pharmacokinet Biopharm. 1984 Dec; 12(6):575-86. Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ, Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ. PMID: 6533293.
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    408. Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine. J Pharm Sci. 1984 Jun; 73(6):831-3. Sörgel F, Lin ET, Hasegawa J, Benet LZ, Sörgel F, Lin ET, Hasegawa J, Benet LZ. PMID: 6737274.
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    409. Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. J Chromatogr. 1984 May 11; 307(2):371-9. Langendijk PN, Smith PC, Hasegawa J, Benet LZ, Langendijk PN, Smith PC, Hasegawa J, Benet LZ. PMID: 6610684.
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    410. High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine. J Chromatogr. 1984 Mar 09; 306:315-21. Smith PC, Benet LZ, Smith PC, Benet LZ. PMID: 6715469.
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    412. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology. 1984; 28(2):90-4. Meister W, Benowitz NL, Benet LZ, Meister W, Benowitz NL, Benet LZ. PMID: 6709691.
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    413. Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies. Pharmacology. 1984; 28(4):181-7. Chiang CW, Benet LZ, Chiang CW, Benet LZ. PMID: 6728896.
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    414. Oral bioavailability and intravenous pharmacokinetics of amrinone in humans. J Pharm Sci. 1983 Jul; 72(7):817-9. Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J, Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J. PMID: 6886991.
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    415. Dose-dependent bioavailability of prazosin in beagle dogs. J Cardiovasc Pharmacol. 1983 Jul-Aug; 5(4):613-7. Baughman RA, Sorgel F, Mico BA, Benet LZ, Baughman RA, Sorgel F, Mico BA, Benet LZ. PMID: 6193359.
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    416. Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases. J Dent Res. 1983 May; 62(5):575-7. Lozada F, Frey FJ, Benet LZ, Lozada F, Frey FJ, Benet LZ. PMID: 6573375.
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    417. Furosemide assays and disposition in healthy volunteers and renal transplant patients. Fed Proc. 1983 Apr; 42(6):1695-8. Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG, Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG. PMID: 6339277.
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    418. The bioavailability and disposition of tiodazosin levulinate in beagle dogs with a comparison to prazosin hydrochloride. Drug Metab Dispos. 1983 Mar-Apr; 11(2):143-6. Baughman RA, Mico BA, Benet LZ, Baughman RA, Mico BA, Benet LZ. PMID: 6133719.
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    420. Plasma protein binding of furosemide in kidney transplant patients. J Pharmacokinet Biopharm. 1982 Dec; 10(6):663-74. Smith DE, Benet LZ, Smith DE, Benet LZ. PMID: 6763626.
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    421. Endogenous and exogenous glucocorticoids in cushingoid patients. Drug Intell Clin Pharm. 1982 Nov; 16(11):863-8. Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM. PMID: 6756849.
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    422. Prednisolone clearance at steady state in man. J Clin Endocrinol Metab. 1982 Oct; 55(4):762-7. Legler UF, Frey FJ, Benet LZ, Legler UF, Frey FJ, Benet LZ. PMID: 7107818.
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    423. Pharmacokinetics of triamterene and its metabolite in man. J Pharmacokinet Biopharm. 1982 Oct; 10(5):507-23. Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ, Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ. PMID: 7166735.
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    424. Disposition of zomepirac sodium in man. J Clin Pharmacol. 1982 Oct; 22(10):470-6. O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ, O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ. PMID: 7174855.
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    425. Apparent intramolecular acyl migration of zomepirac glucuronide. Drug Metab Dispos. 1982 Sep-Oct; 10(5):469-73. Hasegawa J, Smith PC, Benet LZ, Hasegawa J, Smith PC, Benet LZ. PMID: 6128195.
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    426. Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography. J Chromatogr. 1982 Jul 09; 230(2):454-60. Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ, Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ. PMID: 6213630.
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    427. Determination of tiodazosin in plasma and whole blood by high-performance liquid chromatography. J Chromatogr. 1982 Jun 11; 230(1):203-6. Mico BA, Baughman RA, Benet LZ, Mico BA, Baughman RA, Benet LZ. PMID: 7107763.
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    429. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. J Pharm Sci. 1982 May; 71(5):533-5. Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ, Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ. PMID: 7097499.
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    430. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. J Clin Pharmacol. 1982 Jan; 22(1):32-41. Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ, Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ. PMID: 7061724.
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    431. Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. Eur J Clin Pharmacol. 1982; 23(1):65-74. Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ, Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ. PMID: 6751835.
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    433. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. J Clin Pharmacol. 1981 Nov-Dec; 21(11):493-500. Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ, Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ. PMID: 7037867.
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    434. Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica. J Neurochem. 1981 Sep; 37(3):768-74. Mamelok RD, Macrae DR, Benet LZ, Prusiner SB, Mamelok RD, Macrae DR, Benet LZ, Prusiner SB. PMID: 6115891.
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    436. Furosemide kinetics and dynamics after kidney transplant. Clin Pharmacol Ther. 1981 Jul; 30(1):105-13. Smith DE, Gambertoglio JG, Vincenti F, Benet LZ, Smith DE, Gambertoglio JG, Vincenti F, Benet LZ. PMID: 7016396.
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    437. A standard approach to compiling clinical pharmacokinetic data. J Pharmacokinet Biopharm. 1981 Feb; 9(1):59-127. Sheiner LB, Benet LZ, Pagliaro LA, Sheiner LB, Benet LZ, Pagliaro LA. PMID: 7014827.
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    438. Dose-dependent kinetics of probenecid in rhesus monkeys-intravenous bolus studies. Pharmacology. 1981; 23(6):326-36. Chiang CW, Benet LZ, Chiang CW, Benet LZ. PMID: 7312942.
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    442. Prednisolone clearance at steady state in dogs. J Pharmacol Exp Ther. 1980 Nov; 215(2):287-91. Frey FJ, Frey BM, Greither A, Benet LZ, Frey FJ, Frey BM, Greither A, Benet LZ. PMID: 7441495.
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    449. Inhibition by indomethacin of the glycemic response to arginine in man. . 1980 Feb; 163(2):237-9. Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH, Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH. PMID: 6987677.
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    450. Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review. J Pharmacokinet Biopharm. 1980 Feb; 8(1):1-52. Gambertoglio JG, Amend WJ, Benet LZ, Gambertoglio JG, Amend WJ, Benet LZ. PMID: 6991663.
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    454. Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug Metab Dispos. 1979 Nov-Dec; 7(6):373-7. Ding TL, Benet LZ, Ding TL, Benet LZ. PMID: 43222.
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