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Leslie Benet, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address533 Parnassus Ave, UC Hall
San Francisco CA 94143
Phone415-476-3853
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1965 Graduate Division (Pharmaceutical Chemistry)
    Collapse Awards and Honors
    American Pharmacists Association Academy of Pharmaceutical Research and Science (APhA-APRS),20132013 APhA-APRS Ebert Prize
    American Association of Pharmaceutical Scientists2013AAPS Journal Manuscript Award for the Most Outstanding Manuscript
    International Pharmaceutical Federation, The Netherlands2012Honorary Member
    University of Michigan2011Doctor of Science, honoris causa
    National Research Council 2011Named “National Associate”
    American College of Clinical Pharmacology, 40th Annual Meeting, Chicago, IL 2011Distinguished Investigator Award
    Controlled Release Society 2010Elected Fellow
    Catholic University of Leuven, Leuven, Belgium 2010Doctor of Philosophy, honoris causa
    American Society for Clinical Pharmacology and Therapeutics 111th Annual Meeting, Atlanta, Georgia 2010Oscar B. Hunter Memorial Award in Therapeutics
    100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich, Nürnberg, Germany2008Paul Ehrlich Magic-Bullet Award 2008 Lifetime Achievement
    University of California San Francisco2007UCSF 7th Distinguished Clinical Research Lecturer
    Institute for Scientific Information2003ISI Highly Cited Researcher
    of Medical Countermeasures Against Biological Warfare Agents 2002  - 2004Chair, IOM/NRC Committee on Accelerating the Research, Development and Acquisition
    International Pharmaceutical Federation2001Høst-Madsen Medal
    Sichuan University, Sichuan Province, China2014  - 2019Guest Professorship
    Zhengzhou University, Henan Province, China2012Visiting Professor of the First Clinical Medical College of Zhengzhou University, and the Institute
    University of Wisconsin2013Busse Lecture
    NRPB – AAPS Workshop on Clinical and Diagnostic Biomarkers, Taipei, Taiwan2012Invited Keynote Lecture
    Texas Tech University Health Science Center School of Pharmacy Research Days, Texas Tech University2012Invited Keynote Lecture
    Chinese Society of Clinical Pharmacy, Zhengzhou, China2012Honorary Member
    CPSA Shanghai 2012: From Bench to Decision Making – From Basics to Applications, Shanghai, China 2012Invited Plenary Lecture
    International Symposium on Past, Present and Future Molecular Pharmacokinetics, Tokyo, Japan 2012Invited Plenary Lecture
    Horace Rackham School of Graduate Studies, University of Michigan2011Inaugural Albert B. Prescott Distinguished Lecture
    State University of New York at Buffalo2011Gerhard Levy Distinguished Lectureship in Pharmaceutical Sciences
    Biomedical Centre, Uppsala University, Uppsala, Sweden 2011Invited Plenary Lecture, Symposium
    AstraZeneca Research & Development Mölndal, Sweden 2011The AstraZeneca Drug Hunting Lecture
    Thompson Reuters Highly Cited Researcher20141 of 16 pharmacologists worldwide to be listed in both 2001 and 2014 compilations
    2010 Pharmaceutical Sciences World Congress and the AAPS Annual Meeting and Exposition, New Orleans,2010Invited Plenary Lecture
    The 42nd Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), The Ohio State University2010Invited Keynote Lecture
    18th International Symposium on Microsomes and Drug Oxidations, Beijing, China 2010Invited Plenary Lecture
    129th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Japan 2009Invited Plenary Lecture
    University of Athens, Greece 2005Doctor of Philosophy, honoris causa
    9th International Symposium of the Controlled Release Society Indian Chapter, Mumbai, India2009Invited Plenary Lecture
    100th Anniversary of School of Pharmacy, NDMC; 2008 PST & TSHP Joint International Conference2008Invited Keynote Speaker
    2008National Defense Medical Center, Taipei
    2008Nagai Foundation Tokyo Distinguished Lectureship 2008
    28th Annual Meeting of the Japanese Society for Drug Delivery Systems, Tokyo, Japan2008Invited Plenary Lecture
    Modified Release Forum, West Point, PA 2008Invited Plenary Lecture
    109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics2008Invited Featured Speaker
    iMED.UL (Research Institute for Medicines and Pharmaceutical Sciences) University of Lisbon, Portuga2008Chair, Scientific Advisory Board
    8th International Symposium on Advances in Technology & Business Potential of New Drug Delivery Syst2008Keynote Lecture
    Japan Society for the Study of Xenobiotics, Sendai, Japan 2007International Honorary Member
    University of Michigan College of Pharmacy, Ann Arbor, MI 2007Graduation Speaker
    Division of Biocomputing, School of Medicine, University of New Mexico2007Keynote Lecture, Biocomputing Day
    Meeting of the European Drug Absorption Network, Leuven, Belgium 2007Keynote Lecture
    7th International Symposium on Advances in Technology and Business Potential of New Drug Delivery Sy2007Plenary Lecture
    4th International COE Symposium, Target Validation, Lead Optimization & Clinical Development, Tokyo2006Plenary Lecture
    16th International Symposium on Microsomes and Drug Oxidation, Budapest2006Plenary Lecture
    Gordon Research Conference on Drug Metabolism, Plymouth, NH 2006Chair
    Great Lakes Symposium 2006, Buffalo, NY 2006Keynote Address
    Journees Galeniques de Saint-Remy de Provence, Saint-Remy, France 2006Plenary Lecture
    Canadian Society for Pharmaceutical Sciences 9th Annual International Symposium on Pharmaceutical Sc2006Plenary Lecture
    Analytica Conference 2006, Munich, Germany 2006Plenary Lecture
    British Pharmaceutical Conference, Manchester, UK 2005Keynote Address
    2nd International Symposium on Scientific & Regulatory Aspects of Dissolution & Bioequivalence2005Plenary Lecture
    9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology2005Plenary Lecture
    Controlled Release Society 2004 Annual Meeting & Exposition2004Career Achievement Award in Oral Drug Delivery
    Pharmaceutical Sciences World Congress 2004, Kyoto2004Research Achievement Award in Pharmaceutical Sciences
    Romanian Academy of Medical Sciences2003Invested as a “Member of Honour”
    First Congress of the Portuguese Society for Pharmaceutical Sciences2003Opening Plenary Lecture
    International Pharmaceutical Technology Symposium 2002, Istanbul, Turkey 2002Plenary Lecture
    Academia de Ciencias Farmacéuticas de Chile, Santiago, Chile 2002Invested as a “Miembro Honorario”
    10th International Conference on Pharmaceutical Technology, Florence, Italy 2002Plenary Lecture
    American Association of Indian Pharmaceutical Scientists2001Elected Fellow
    FDA/CDER and ASCPT2015William B. Abrams Lectureship
    Medical Technology Schools2015Listed among "25 Top Pharmacy Professors" in the U.S.A.
    Thomson Reuters2014Highly cited Researcher-Pharmacology
    Medical Technology Schools2015"25 Top Pharmacy Professors" in USA
    FDA/CDER and American Society for Clinical Pharmacology and Therapeutics2015William B. Abrams Lectureship
    International Society for the Study of Xenobiotics2015North American Scientific Achievement Award
    American Pharamacists Association2016Remington Honor Medal
    University of Lisbon, Portugal2016Doctor of Philosophy, honoris causa

    Collapse Overview 
    Collapse Overview
    Dr. Benet, Professor and former Chairman (1978-1998), Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, received his A.B. (English), B.S. (Pharmacy), M.S. from the University of Michigan and Ph.D. from the University of California. He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and Universidade de Lisboa, Lisbon, Portugal (Ph.D., 2016). His research interests, more than 570 publications, 6 books and 11 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Thompson Reuters as one of the most highly cited pharmacologists worldwide, with his published peer-reviewed papers cited more than 20,000 times. His most recent work has addressed the interplay of metabolic enzymes and transport proteins as related to oral bioavailability and hepatic elimination, and the development of the Biopharmaceutics Drug Disposition Classification System (BDDCS). Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY, CHEMICAL AND PHARMACEUTICAL BULLETIN, AAPS JOURNAL and ARCHIVES OF DRUG INFORMATION. He is a Fellow of the Academy of Pharmaceutical Sciences and Research, the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP), the Controlled Release Society (CRS) and the American Association for the Advancement of Science. In 1982, Dr. Benet received the American Pharmacists Association (APhA) Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the Institute of Medicine (IOM) of the National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the initial AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) and delivered the American College of Clinical Pharmacy “Therapeutic Frontiers Lecture”. In 1996, he received the AAPS Distinguished Service Award, and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award. In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer and is still the only non-MD so honored. In 2010, he received the ASCPT Hunter Memorial Award in Therapeutics and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor under the title “50 Years of Scientific Excellence and Still Going Strong” and he was made an honorary member of FIP. In March 2013, he was awarded the APhA Ebert Prize and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated IOM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and as a member of the FDA Generic Drugs Advisory Committee, the FDA Science Board and the NRC Biodefense Standing Committee. From 2007-2012 he served as Chair of the FIP Foundation for Education and Research. He presently serves on the Boards of Directors of the American Foundation for Pharmaceutical Education, Impax Laboratories, and Medicines360, of which the latter, he chairs. SEPTEMBER 2013

    Collapse Research 
    Collapse Research Activities and Funding
    A novel mechanistic modeling platform for predicting drug clearance and disposition mediated by transporters and enzymes
    NIH/NIGMS R43GM113597Jan 15, 2015 - Oct 14, 2015
    Role: Co-Principal Investigator
    A Transporter-Based Predictive ADME Platform
    NIH/NCRR R43RR031474May 15, 2010 - May 14, 2011
    Role: Principal Investigator
    Transporter-Enzyme Interplay Evaluation via Microfluidiic HTS Cell Culture Device
    NIH/NIGMS R21GM075900Jun 2, 2006 - May 31, 2009
    Role: Principal Investigator
    GENDER EFFECTS ON HIV BIOLOGY
    NIH/NICHD P01HD040543Apr 23, 2001 - Mar 31, 2008
    Role: Co-Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 1, 1998 - Nov 30, 2002
    Role: Co-Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH/NIGMS R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Principal Investigator
    SCIENTIFIC REVIEW AND EVALUATION AWARD - PHARMACOLOGICAL
    NIH/NIGMS U09GM007709Aug 1, 1989 - Oct 31, 1987
    Role: Co-Principal Investigator
    ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    NIH/NIGMS R01GM036633Apr 1, 1986 - Nov 30, 1994
    Role: Principal Investigator
    NITROGLYCERIN DINITRATE METABOLITES--KINETICS/DYNAMICS
    NIH/NHLBI R01HL032243Apr 1, 1984 - Mar 31, 1987
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH/NIGMS P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Sep 29, 2006
    Role: Co-Investigator

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    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. Pharm Res. 2020 Sep 29; 37(10):208. Sodhi JK, Liu S, Benet LZ. PMID: 32996065.
      View in: PubMed   Mentions:    Fields:    
    2. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. AAPS J. 2020 Sep 10; 22(5):120. Benet LZ, Sodhi JK. PMID: 32914238.
      View in: PubMed   Mentions:    Fields:    
    3. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. AAPS J. 2020 Aug 17; 22(5):111. Sodhi JK, Benet LZ. PMID: 32808084.
      View in: PubMed   Mentions:    Fields:    
    4. The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem. 2020 Aug 02. Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K. PMID: 32743945.
      View in: PubMed   Mentions:    Fields:    
    5. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clin Pharmacokinet. 2020 Jul 28. Sodhi JK, Huang CH, Benet LZ. PMID: 32725383.
      View in: PubMed   Mentions:    Fields:    
    6. A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clin Pharmacol Ther. 2020 Aug; 108(2):306-315. Sodhi JK, Benet LZ. PMID: 32150643.
      View in: PubMed   Mentions: 1     Fields:    
    7. Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Drug Metab Dispos. 2020 Jul; 48(7):537-543. Sodhi JK, Wang HJ, Benet LZ. PMID: 32305951.
      View in: PubMed   Mentions:    Fields:    
    8. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System. Pharmacotherapy. 2020 04; 40(4):274-290. Liu W, Yan T, Chen K, Yang L, Benet LZ, Zhai S. PMID: 32100890.
      View in: PubMed   Mentions:    Fields:    
    9. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions. Pharm Res. 2020 Mar 25; 37(4):73. Sodhi JK, Liu S, Benet LZ. PMID: 32215750.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology. 2020; 105(3-4):145-163. Sun A, Benet LZ. PMID: 31910414.
      View in: PubMed   Mentions: 2     Fields:    
    11. Can BDDCS illuminate targets in drug design? Drug Discov Today. 2019 12; 24(12):2299-2306. Bocci G, Benet LZ, Oprea TI. PMID: 31585170.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    12. Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation. Drug Metab Dispos. 2019 12; 47(12):1397-1402. Wang HJ, Benet LZ. PMID: 31563869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug Metab Dispos. 2019 12; 47(12):1368-1371. Bowman CM, Benet LZ. PMID: 31551322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharm Res. 2019 Sep 04; 36(11):155. Surofchy DD, Frassetto LA, Benet LZ. PMID: 31485804.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. How Transporters Have Changed Basic Pharmacokinetic Understanding. AAPS J. 2019 09 03; 21(6):103. Benet LZ, Bowman CM, Sodhi JK. PMID: 31482335.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    16. The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats. Drug Metab Dispos. 2019 09; 47(9):1004-1012. Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. PMID: 31201213.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharm Res. 2019 May 31; 36(8):113. Bowman CM, Benet LZ. PMID: 31152241.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. J Pharmacokinet Pharmacodyn. 2019 04; 46(2):155-163. Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. PMID: 30911879.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction. J Pharm Sci. 2019 07; 108(7):2500-2504. Bowman CM, Benet LZ. PMID: 30817922.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Characterization of Fasiglifam-Related Liver Toxicity in Dogs. Drug Metab Dispos. 2019 05; 47(5):525-534. Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. PMID: 30765394.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    21. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug Metab Dispos. 2019 04; 47(4):358-363. Bowman CM, Okochi H, Benet LZ. PMID: 30674616.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 02; 105(2):411-416. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. PMID: 30652304.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    23. Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clin Pharmacol Ther. 2019 02; 105(2):326-328. Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E. PMID: 30652313.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    25. The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharm Res. 2018 Oct 22; 35(12):242. Benet LZ, Bowman CM, Liu S, Sodhi JK. PMID: 30349948.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox Biol. 2019 01; 20:349-353. Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. PMID: 30391827.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    27. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine. 2018 Aug-Sep; 2-3:22-28. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. PMID: 30906930.
      View in: PubMed   Mentions:
    28. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. Eur J Pharm Sci. 2018 Oct 15; 123:502-514. Bowman CM, Benet LZ. PMID: 30098391.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification. Toxicol Res (Camb). 2018 May 08; 7(3):358-370. Chan R, Benet LZ. PMID: 29785262.
      View in: PubMed   Mentions:
    30. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. J Clin Pharmacol. 2018 Apr 17. Benet LZ. PMID: 29663413.
      View in: PubMed   Mentions: 2     Fields:    
    31. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Toxicol Sci. 2018 04 01; 162(2):499-508. Chan R, Benet LZ. PMID: 29272540.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clin Ther. 2018 04; 40(4):660-662. Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. PMID: 29551534.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2018 Mar 15; 32(5):431-441. Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. PMID: 29315954.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    34. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. AAPS J. 2018 03 13; 20(3):46. Parasrampuria DA, Benet LZ, Sharma A. PMID: 29536211.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Sci Rep. 2018 01 08; 8(1):92. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. PMID: 29311658.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    36. Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States. Clin Infect Dis. 2018 01 06; 66(2):213-219. Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. PMID: 29020194.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansPHPublic Health
    37. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2018 03; 103(3):521-525. Benet LZ, Liu S, Wolfe AR. PMID: 28762489.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-ß-D-Glucuronide". Clin Transl Sci. 2017 07; 10(4):240-241. Morrissey KM, Benet LZ, Ware JA. PMID: 28664655.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    39. Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics. J Pharm Sci. 2017 09; 106(9):2231-2233. Benet LZ, Wu HF. PMID: 28502797.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 09; 106(9):2895-2898. Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. PMID: 28385546.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    41. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. PMID: 28385543.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    42. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chem Res Toxicol. 2017 04 17; 30(4):1017-1029. Chan R, Benet LZ. PMID: 28257576.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS Res Hum Retroviruses. 2017 08; 33(8):778-783. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. PMID: 28253024.
      View in: PubMed   Mentions: 26     Fields:    
    44. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. PMID: 28028768.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    45. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chin J Nat Med. 2016 Dec; 14(12):888-897. Li J, Larregieu CA, Benet LZ. PMID: 28262115.
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    47. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV. 2016 11; 3(11):e521-e528. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. PMID: 27658870.
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    49. 2016 Remington Honor Medal Address: Science for the profession. J Am Pharm Assoc (2003). 2016 Jul-Aug; 56(4):365-8. Benet LZ. PMID: 27450136.
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    50. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Int J Tuberc Lung Dis. 2016 06; 20(6):844-7. Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. PMID: 27155191.
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    53. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. AAPS J. 2016 05; 18(3):757-66. Chan R, Wei CY, Chen YT, Benet LZ. PMID: 26951484.
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    54. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clin Pharmacokinet. 2016 Feb; 55(2):143-67. Zheng Y, Chen X, Benet LZ. PMID: 26293617.
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    58. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharm Res. 2015 Aug; 32(8):2516-26. Zheng Y, Benet LZ, Okochi H, Chen X. PMID: 25690341.
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    59. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. PMID: 25776193.
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    61. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. PMID: 25274610.
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    62. Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J. 2014 Sep; 16(5):1085-96. Hosey CM, Broccatelli F, Benet LZ. PMID: 25004821.
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    65. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. PMID: 24572354.
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    131. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Nephrology (Carlton). 2005 Aug; 10(4):393-9. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. PMID: 16109088.
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    132. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 16003227.
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    133. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. J Clin Pharmacol. 2005 Apr; 45(4):411-21. Putnam WS, Woo JM, Huang Y, Benet LZ. PMID: 15778422.
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    137. Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Pharm Res. 2005 Jan; 22(1):79-85. Mohri K, Okada K, Benet LZ. PMID: 15771233.
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    138. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metab Dispos. 2004 Nov; 32(11):1311-6. Lam JL, Benet LZ. PMID: 15483198.
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    139. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit. 2004 Oct; 26(5):546-62. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. PMID: 15385839.
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    140. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Catheter Cardiovasc Interv. 2004 Oct; 63(2):222-30. Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. PMID: 15390346.
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    141. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. PMID: 15339861.
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    142. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov; 32(11):1239-46. Sun H, Huang Y, Frassetto L, Benet LZ. PMID: 15286055.
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    143. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul; 21(7):1284-93. Kim WY, Benet LZ. PMID: 15290871.
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    145. Pharmacogenomics and transplantation: where are we? Am J Transplant. 2004 Jun; 4(6):843. Frassetto LA, Benet LZ. PMID: 15147415.
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    146. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107. Serkova NJ, Christians U, Benet LZ. PMID: 15087483.
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    147. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther. 2004 Mar; 308(3):1040-5. Lau YY, Wu CY, Okochi H, Benet LZ. PMID: 14634033.
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    148. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metab Dispos. 2003 Nov; 31(11):1292-5. Wu CY, Benet LZ. PMID: 14570757.
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    149. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan; 308(1):143-55. Cummins CL, Jacobsen W, Christians U, Benet LZ. PMID: 14569063.
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    150. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab. 2003 Oct; 4(5):393-8. Benet LZ, Cummins CL, Wu CY. PMID: 14529371.
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    151. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Drug Metab Dispos. 2003 Jun; 31(6):727-30. Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. PMID: 12756204.
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    153. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther. 2003 Apr; 305(1):306-14. Cummins CL, Salphati L, Reid MJ, Benet LZ. PMID: 12649383.
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    154. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Toxicol Appl Pharmacol. 2003 Mar 01; 187(2):101-9. Li C, Grillo MP, Benet LZ. PMID: 12649042.
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    155. Pharmacokinetics of cyclosporine pre- and post-liver transplantation. J Clin Pharmacol. 2003 Jan; 43(1):38-42. Hebert MF, Wacher VJ, Roberts JP, Benet LZ. PMID: 12520626.
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    156. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. PMID: 15618725.
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    157. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Med. 2002 Dec; 68(12):1055-8. Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. PMID: 12494328.
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    158. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. J Pharm Sci. 2002 Dec; 91(12):2622-35. Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. PMID: 12434407.
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    159. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. Chem Res Toxicol. 2002 Nov; 15(11):1480-7. Li C, Benet LZ, Grillo MP. PMID: 12437340.
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    160. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther. 2002 Nov; 72(5):474-89. Cummins CL, Wu CY, Benet LZ. PMID: 12426511.
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    161. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. Chem Res Toxicol. 2002 Oct; 15(10):1309-17. Li C, Benet LZ, Grillo MP. PMID: 12387630.
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    162. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J Pharmacol Exp Ther. 2002 Sep; 302(3):1123-8. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. PMID: 12183671.
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    163. Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells. J Pharm Sci. 2002 Apr; 91(4):1169-77. Flanagan SD, Takahashi LH, Liu X, Benet LZ. PMID: 11948555.
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    164. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res. 2002 Apr; 19(4):457-62. Susanto M, Benet LZ. PMID: 12033380.
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    165. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. PMID: 11891440.
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    166. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther. 2002 Mar; 71(3):115-21. Benet LZ, Hoener BA. PMID: 11907485.
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    167. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. J Clin Pharmacol. 2002 Mar; 42(3):304-11. Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. PMID: 11865967.
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    168. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002 Mar; 300(3):1036-45. Cummins CL, Jacobsen W, Benet LZ. PMID: 11861813.
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    169. Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 15; 767(2):245-53. Unger M, Jacobsen W, Holzgrabe U, Benet LZ. PMID: 11885853.
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    170. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet. 2002; 41(11):813-51. Christians U, Jacobsen W, Benet LZ, Lampen A. PMID: 12190331.
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    171. Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro. Drug Metab Dispos. 2002 Jan; 30(1):55-62. Grillo MP, Benet LZ. PMID: 11744612.
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    172. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002; 64(3):126-34. Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. PMID: 11834888.
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    173. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharm Res. 2002 Jan; 19(1):27-33. Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. PMID: 11837697.
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    174. Red wine decreases cyclosporine bioavailability. Clin Pharmacol Ther. 2001 Nov; 70(5):462-7. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. PMID: 11719733.
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    175. The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev. 2001 Oct 01; 50 Suppl 1:S3-11. Benet LZ, Cummins CL. PMID: 11576692.
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    176. Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats. Drug Metab Dispos. 2001 Sep; 29(9):1210-5. Grillo MP, Chiellini G, Tonelli M, Benet LZ. PMID: 11502730.
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    178. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res. 2001 Aug; 18(8):1102-9. Cummins CL, Mangravite LM, Benet LZ. PMID: 11587480.
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    180. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J Med Chem. 2001 Jun 07; 44(12):2027-34. Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. PMID: 11384247.
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    182. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc. 2001 Feb-Mar; 33(1-2):514-5. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. PMID: 11266932.
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    183. Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers. J Heart Lung Transplant. 2001 Feb; 20(2):234-235. Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L. PMID: 11250452.
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    186. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry. Adv Exp Med Biol. 2001; 500:663-73. Qiu Y, Benet LZ, Burlingame AL. PMID: 11765013.
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    187. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharm Res. 2001 Jan; 18(1):39-44. Parasrampuria DA, Lantz MV, Benet LZ. PMID: 11336351.
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    189. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos. 2000 Nov; 28(11):1369-78. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. PMID: 11038166.
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    190. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov; 28(11):1343-51. Jacobsen W, Christians U, Benet LZ. PMID: 11038163.
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    191. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl. 2000 Oct 01; 748(1):41-53. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. PMID: 11092585.
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    194. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar; 129(6):1235-43. Soldner A, Benet LZ, Mutschler E, Christians U. PMID: 10725273.
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    197. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos. 1999 Dec; 27(12):1505-11. Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ. PMID: 10570034.
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    199. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. J Pharmacol Exp Ther. 1999 Oct; 291(1):131-9. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. PMID: 10490896.
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    200. Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin. Br J Clin Pharmacol. 1999 Jul; 48(1):79-87. Mizuma T, McDonagh AF, Lin ET, Benet LZ. PMID: 10383564.
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    209. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb; 27(2):173-9. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. PMID: 9929499.
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    212. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. J Chromatogr B Biomed Sci Appl. 1998 Dec 11; 720(1-2):179-87. Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. PMID: 9892080.
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    217. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers. Pharm Res. 1998 Oct; 15(10):1520-4. Zhang Y, Benet LZ. PMID: 9794492.
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    218. Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation. Transplant Proc. 1998 Aug; 30(5):1650-1. Benet LZ. PMID: 9723227.
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    219. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem. 1998 Jul 10; 273(28):17940-53. Qiu Y, Benet LZ, Burlingame AL. PMID: 9651401.
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    220. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther. 1998 Jun; 285(3):1104-12. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. PMID: 9618413.
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    222. Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide. Drug Metab Dispos. 1998 Apr; 26(4):332-7. Mohri K, Okada K, Benet LZ. PMID: 9531520.
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    229. Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. Drug Metab Dispos. 1997 Oct; 25(10):1119-22. Jang GR, Benet LZ. PMID: 9321513.
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    230. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther. 1997 Sep; 62(3):248-60. Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. PMID: 9333100.
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    231. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clin Pharmacol Ther. 1997 Jul; 62(1):41-9. Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF. PMID: 9246018.
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    232. Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo. J Pharmacol Exp Ther. 1997 Jun; 281(3):1499-505. Yuan R, Sumi M, Benet LZ. PMID: 9190888.
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    233. Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):133-40. Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET. PMID: 9187392.
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    234. Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):149-56. Wu ST, Benet LZ, Lin ET. PMID: 9187394.
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    239. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochem Pharmacol. 1996 Sep 13; 52(5):753-61. Jang GR, Wrighton SA, Benet LZ. PMID: 8765473.
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    241. Acute dose-dependent disposition studies of nicotinic acid in rats. Drug Metab Dispos. 1996 Jul; 24(7):773-9. Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ. PMID: 8818575.
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    243. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica. 1996 Apr; 26(4):381-94. Berg-Candolfi M, Candolfi E, Benet LZ. PMID: 9173679.
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    245. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica. 1996 Mar; 26(3):275-84. Jaeger W, Benet LZ, Bornheim LM. PMID: 8730919.
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    251. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct; 23(10):1099-103. Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ. PMID: 8654198.
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    252. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos. 1995 Sep; 23(9):900-3. Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ. PMID: 8565778.
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    254. Gender effects in pharmacokinetics and pharmacodynamics. Drugs. 1995 Aug; 50(2):222-39. Harris RZ, Benet LZ, Schwartz JB. PMID: 8521756.
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    256. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995 Jul; 13(3):129-34. Wacher VJ, Wu CY, Benet LZ. PMID: 7619215.
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    257. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther. 1995 Jul; 58(1):15-9. Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. PMID: 7628178.
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    259. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharm Drug Dispos. 1995 May; 16(4):303-12. Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. PMID: 7548779.
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    260. 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 07; 666(1):45-53. Haj-Yehia AI, Benet LZ. PMID: 7655620.
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    261. Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats. J Pharmacol Exp Ther. 1995 Apr; 273(1):94-100. Haj-Yehia AI, Benet LZ. PMID: 7714819.
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    262. Biliary excretion of furosemide glucuronide in rabbits. Biol Pharm Bull. 1995 Mar; 18(3):447-53. Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ. PMID: 7550101.
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    263. Basic principles of pharmacokinetics. Toxicol Pathol. 1995 Mar-Apr; 23(2):115-23. Benet LZ, Zia-Amirhosseini P. PMID: 7569664.
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    266. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nat Med. 1995 Jan; 1(1):2-4. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. PMID: 7584944.
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    267. Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole. Pharm Res. 1995 Jan; 12(1):155-60. Haj-Yehia AI, Benet LZ. PMID: 7724479.
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    268. Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase. Biochem Pharmacol. 1994 Dec 16; 48(12):2231-5. Kenkare SR, Han C, Benet LZ. PMID: 7811305.
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    269. Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction. J Chromatogr B Biomed Appl. 1994 Nov 04; 661(1):154-8. Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ. PMID: 7866544.
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