Arun Wiita, MD, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
Address185 Berry Street Bldg B
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Princeton UniversityA.B.2002Chemistry
    Columbia UniversityMD/PhD2009Medicine/Biophysics
    UCSFResidency2012Laboratory Medicine
    UCSFPost-doc2014Pharmaceutical Chemistry
    Collapse Awards and Honors
    Gabrielle's Angels Foundation for Cancer Research2017Janet Rowley Memorial Medical Research Award
    NIH Director's Common Fund2016New Innovator Award (DP2)
    Doris Duke Charitable Foundation2016Clinical Scientist Development Award
    Damon Runyon Cancer Research Foundation2015Dale Frey Breakthrough Award
    UCSF-American Cancer Society2015Individual Research Award
    NIH-NCI2014  - 2019K08 Mentored Clinical Scientist Award
    Damon Runyon Cancer Research Foundation2012  - 2014Post-doctoral Fellowship
    Columbia University2008Dean's Award for Excellence in Research (top PhD thesis prize)

    Collapse Overview 
    Collapse Overview
    My research laboratory spans a number of areas within genomics, proteomics, and hematologic malignancies. One major area of research involves the use of targeted, quantitative proteomics to answer important biological questions in myeloma and B-cell leukemia. We are particularly interested in questions related to translational regulation after cancer therapy as well as how clinically-relevant genomic alterations result in phenotypic changes at the level of the proteome. Furthermore, my group includes the UCSF Stephen and Nancy Grand Multiple Myeloma Translational Initiative Laboratory. In this role, we collaborate with industry and academic partners to advance preclinical evaluation of novel myeloma therapeutics using a suite of in vitro and in vivo approaches.

    In my clinical work, I am Assistant Director of the UCSF Clinical Cytogenetics laboratory. In this role, I interpret molecular genetic testing for the prenatal and postnatal diagnosis of microdeletion and microduplication syndromes. In this area we have translational interests in emerging technologies for determination of DNA copy number variation, integration of single-nucleotide variants and CNV interpretation, and cell-free DNA for prenatal testing. In my research laboratory we are also using quantitative proteomics to evaluate the role of protein homeostasis in determining the phenotypic effects of CNVs, as well using CRISPR/Cas9 genome engineering to generate new functional models of syndromic CNVs.

    Collapse Research 
    Collapse Research Activities and Funding
    Structural Surfaceomics: A Strategy for Immunotherapy Target Discovery
    NIH R21CA263229Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Immuno Oncology Product for Multiple Myeloma: g-NK Cellular Therapy to Optimize Monoclonal Antibody Efficacy in Treating Multiple
    NIH R43CA235786May 15, 2019 - Feb 29, 2020
    Role: Co-Principal Investigator
    Exploiting myeloma proteome remodeling to extend proteasome inhibitor efficacy
    NIH R01CA226851Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    In vivo monitoring of oxidative protein folding through time-resolved quantitative mass spectrometry
    NIH DP2GM123500Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Global Assessment of Myeloma Response to Chemotherapy
    NIH K08CA184116Sep 16, 2014 - Aug 31, 2019
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL. Cancer Discov. 2021 Mar 16. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera J, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann B, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. PMID: 33727310.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2021 Mar 12. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33712811.
      View in: PubMed   Mentions: 1     Fields:    
    3. A Guide to Using ClinTAD for Interpretation of DNA Copy Number Variants in the Context of Topologically Associated Domains. Curr Protoc Hum Genet. 2020 12; 108(1):e106. Spector JD, Wiita AP. PMID: 33170544.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Phase II Study of Daratumumab in Combination with Azacitidine and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Daratumumab: Darazadex. Blood. 2020 Nov 5; 136(Supplement 1):27-28. Swetha Kambhampati, Sandy W. Wong, Thomas Martin, Jeffrey L. Wolf, Priya Choudhry, William Karlon, Arun P. Wiita, Nina Shah. .
      View in: Publisher Site   Mentions:
    5. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2020 12; 588(7838):491-497. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33149299.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 33093202.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    7. MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309. August Dietrich, Cassandra Burnett, Thomas Martin, Arun Wiita, Kole Roybal, Justin Eyquem. .
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    8. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 01. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586.
      View in: PubMed   Mentions:
    9. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 07; 583(7818):845-851. Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. PMID: 32699415.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi. Am J Surg Pathol. 2020 06; 44(6):849-858. Han LM, Grenert JP, Wiita AP, Quinn M, Fujimoto VY, Rabban JT. PMID: 32205485.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):e20547-e20547. Swetha Kambhampati, Kwun Wah Wen, Victoria Sung, Sandy Wai Kuan Wong, Thomas G. Martin, Jeffrey Lee Wolf, Nina Shah, Arun Wiita. .
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    13. Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Nat Commun. 2020 04 22; 11(1):1931. Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP. PMID: 32321912.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020 03; 579(7799):427-432. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. PMID: 32132707.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    15. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Leukemia. 2020 10; 34(10):2754-2765. Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP. PMID: 32123307.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    17. Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancer. Adv Exp Med Biol. 2020; 1243:147-162. Kambhampati S, Wiita AP. PMID: 32297217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. X-linked duplication copy number variation in a familial overgrowth condition. Am J Med Genet C Semin Med Genet. 2019 12; 181(4):644-649. Ha TK, Mardy AH, Beleford D, Spanier A, Wayman BV, Penon-Portmann M, Wiita AP, Shieh JT. PMID: 31762227.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology. Blood. 2019 Nov 13; 134(Supplement_1):1803-1803. Ian Ferguson, Yu-Hsiu T. Lin, Sami Tuomivaara, Jeffrey L. Wolf, Thomas G. Martin, Sandy W. Wong, Nina D. Shah, Christoph Driessen, Brian G. Van Ness, Arun P. Wiita. .
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    20. Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation. Blood. 2019 Nov 13; 134(Supplement_1):3944-3944. Lai N Chan, Mark A. Murakami, Rebecca Caesar, Christian Hurtz, Kohei Kume, Teresa Sadras, Seyedmehdi Shojaee, Petri Pölönen, Amol Ugale, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Merja Heinäniemi, Olli Lohi, Arun P. Wiita, Shai Izraeli, David M Weinstock, Markus Müschen. .
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    21. In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies. Blood. 2019 Nov 13; 134(Supplement_1):1337-1337. Matthew Nix, Yu-Hsiu T. Lin, Huimin Geng, Makeba Marcoulis, Paul Phojanakong, Donghui Wang, Veronica Steri, Jeffrey Whitman, Sagar Bapat, Elliot Stieglitz, Anne Deucher, Kristie L White, Byron C Hann, Arun P. Wiita. .
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    22. Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis. Blood. 2019 Nov 13; 134(Supplement_1):2782-2782. Jaewoong Lee, Gang Xiao, Kadriye Nehir Nehir Cosgun, Huimin Geng, Ning Ma, Lai N Chan, Kohei Kume, Matthew Nix, Zhengshan Chen, Chun-Wei David Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Michael S. Diamond, Jae U Jung, Nagarajan Vaidehi, Markus Müschen. .
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    23. Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Blood Adv. 2019 11 12; 3(21):3214-3227. Lin YT, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP. PMID: 31698452.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia. 2020 03; 34(3):938-941. Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP. PMID: 31595037.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e76. Vishesh Sarin, Katharine Yu, Marina Sirota, Arun Wiita. .
      View in: Publisher Site   Mentions:
    26. DNA methyltransferase inhibitors upregulate CD38 expression and enhance daratumumab efficacy in multiple myeloma. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e144-e145. Priya Choudhry, Margarette Mariano, Huimin Geng, Arun Wiita. .
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    27. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. PMID: 31182586.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. MAbs. 2019 May/Jun; 11(4):639-652. Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S. PMID: 30698484.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains. J Hum Genet. 2019 May; 64(5):437-443. Spector JD, Wiita AP. PMID: 30765865.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. 880: Variants of uncertain significance in prenatal microarrays. American Journal of Obstetrics and Gynecology. 2019 Jan 1; 220(1):s572-s573. Anne H. Mardy, Teresa N. Sparks, Arun P. Wiita, Kathryn Drexler, Brette V. Wayman, Allan Nadel, Mary E. Norton. .
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    31. Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001. Oncotarget. 2018 Dec 28; 9(102):37700-37714. Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A. PMID: 30701025.
      View in: PubMed   Mentions: 6     Fields:    
    32. IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation. Blood. 2018 Nov 29; 132(Supplement 1):552-552. Jae-Woong Lee, Huimin Geng, Derek S Dinson, Gang Xiao, Kadriye Nehir Cosgun, Lai N Chan, Zhengshan Chen, Michael Farzan, Jae U Jung, Arun P Wiita, Markus Muschen. .
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    33. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):3212-3212. Ian Ferguson, Christine Lam, Margarette C. Mariano, Donghui Wang, Paul Phojanakong, Sami Toumivaara, Hao Shao, Byron C Hann, Jason Gestwicki, Arun P Wiita. .
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    34. DNA Methyltransferase Inhibitors Increase Expression of CD38 and Enhance Daratumumab Efficacy in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):5618-5618. Priya Choudhry, Margarette C. Mariano, Arun P Wiita. .
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    35. Integrating Phosphoproteomics and Transcriptional Classifiers Reveals "Hidden Signaling" in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects. Blood. 2018 Nov 29; 132(Supplement 1):469-469. Yu-Hsiu T. Lin, Gergory P. Way, Margarette C. Mariano, Makeba Marcoulis, Ian Ferguson, Casey S. Greene, Arun P Wiita. .
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    36. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann. .
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    37. Fine Needle Aspiration is an Effective Method for Cell Surface Proteomics: Towards a Personalized Cancer Surfaceome. Journal of the American Society of Cytopathology. 2018 Sep 1; 7(5):s86-s87. Jeffrey Whitman, Dianna Ng, Matthew Nix, Kevin Leung, Ronald Balassanian, Arun Wiita. .
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    38. Seeking Convergence and Cure with New Myeloma Therapies. Trends Cancer. 2018 08; 4(8):567-582. Choudhry P, Galligan D, Wiita AP. PMID: 30064664.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):8034-8034. Ben Buelow, Priya Choudry, Starlynn Clarke, Kevin Dang, Laura Davison, Shelley Force Aldred, Katherine Harris, Payal Pratap, Duy Pham, Udaya Rangaswamy, Ute Schellenberger, Nina Shah, Nathan Trinklein, Harshad Ugamraj, Arun Wiita, Wim Van Schooten. .
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    40. Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. 2018 07; 103(7):1218-1228. Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. PMID: 29622655.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    41. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. PMID: 29476136.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    42. Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 2018 Feb 10; 36(5_suppl):60-60. Ben Buelow, Priya Choudhry, Starlynn Clarke, Kevin Dang, Laura Davison, Shelley Force Aldred, Katherine Harris, Duy Pham, Payal Pratap, Udaya Rangaswamy, Ute Schellenberger, Nina Shah, Nathan Trinklein, Harshad Ugamraj, Arun Wiita, Wim Van Schooten. .
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    43. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. PMID: 29212016.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    44. The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma. . 2017 11; 16(11):2375-2386. Le Moigne R, Aftab BT, Djakovic S, Dhimolea E, Valle E, Murnane M, King EM, Soriano F, Menon MK, Wu ZY, Wong ST, Lee GJ, Yao B, Wiita AP, Lam C, Rice J, Wang J, Chesi M, Bergsagel PL, Kraus M, Driessen C, Kiss von Soly S, Yakes FM, Wustrow D, Shawver L, Zhou HJ, Martin TG, Wolf JL, Mitsiades CS, Anderson DJ, Rolfe M. PMID: 28878026.
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    45. Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics. Cell Syst. 2017 06 28; 4(6):636-644.e9. Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP. PMID: 28578850.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    46. Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 2017 May 20; 35(15_suppl):8017-8017. Ben Buelow, Duy Pham, Starlynn Clarke, Shelley Force Aldred, Kevin Dang, Payal Pratap, Harshad Ugamraj, Katherine Harris, Nathan Trinklein, Ute Schellenberger, Arun Wiita, Wim Van Schooten, Ben Buelow. .
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    47. False negative fetal cell free DNA screening for microdeletion syndromes in the presence of an unbalanced translocation involving monosomy 4p. Prenat Diagn. 2017 04; 37(4):420-422. Qi Z, Madaan S, Chetty S, Yu J, Wiita AP. PMID: 28207935.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Hijacking Myeloma Metabolism to Target Cytotoxic Chemotherapy to Malignant Plasma Cells With Decreased Bone Marrow Toxicity. Clinical Lymphoma Myeloma & Leukemia. 2017 Feb 1; 17(1):e53. Arun Wiita, Hui Liu, Christine Lam, Bernd Jandeleit, Wolf-Nicolas Fischer, Kerry Koller, Byron Hann. .
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    49. CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate. Blood. 2016 Dec 2; 128(22):384-384. Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun P. Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, Bin Liu. .
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    50. Tofacitinib Reverses Growth Promoting Effects of the Bone Marrow Stromal Environment Though Inhibition of JAK1/STAT3 Signaling in Multiple Myeloma. Blood. 2016 Dec 2; 128(22):2098-2098. Christine Lam, Megan Murnane, Geoffrey A. Smith, Jack Taunton, Blake T. Aftab, Arun P. Wiita. .
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    51. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 12 01; 126(12):4640-4653. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. PMID: 27841764.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    52. False positive cell free DNA screening for microdeletions due to non-pathogenic copy number variants. Prenat Diagn. 2016 Jun; 36(6):584-6. Mather CA, Qi Z, Wiita AP. PMID: 27061292.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    54. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500.
      View in: PubMed   Mentions: 32     Fields:    
    55. Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma. Blood. 2015 Dec 3; 126(23):503-503. Megan Murnane, Eugen Dhimolea, Ruojing Li, Megan A. Bariteau, Diamond D. Wheeler, Rosemary J. Akhurst, Aaron C. Logan, Pamela Munster, Arun Wiita, Thomas G. Martin, Jeffrey L. Wolf, Jun O. Liu, Constantine S. Mitsiades, Blake T. Aftab. .
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    56. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7594-9. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. PMID: 24821784.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    57. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. PMID: 24443746.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimals
    58. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods Enzymol. 2014; 544:327-58. Wiita AP, Seaman JE, Wells JA. PMID: 24974296.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    59. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    60. Evaluation of Glutamate Dehydrogenase Immunoassay Screening with Toxin Confirmation for the Diagnosis of Clostridium difficile Infection. Lab Medicine. 2013 Aug 1; 44(3):e65-e71. Steve Miller, Arun Wiita, Carolyn Wright, Helen Reyes, Catherine Liu. .
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    61. Longitudinal management with crossmatch-compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes (CME). Transfusion. 2012 Oct; 52(10):2146-54. Wiita AP, Nambiar A. PMID: 23113654.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    62. Clinical application of high throughput molecular screening techniques for pharmacogenomics. Pharmgenomics Pers Med. 2011; 4:109-21. Wiita AP, Schrijver I. PMID: 23226057.
      View in: PubMed   Mentions:
    63. Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology. 2009 Dec 1; 16(12):1331-1331. Raul Perez-Jimenez, Jingyuan Li, Pallav Kosuri, Inmaculada Sanchez-Romero, Arun P Wiita, David Rodriguez-Larrea, Ana Chueca, Arne Holmgren, Antonio Miranda-Vizuete, Katja Becker, Seung-Hyun Cho, Jon Beckwith, Eric Gelhaye, Jean P Jacquot, Eric A Gaucher, Jose M Sanchez-Ruiz, Bruce J Berne, Julio M Fernandez. .
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    64. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol. 2009 Aug; 16(8):890-6. Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Gaucher E, Sanchez-Ruiz JM, Berne BJ, Fernandez JM. PMID: 19597482.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    65. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. J Biol Chem. 2008 Oct 03; 283(40):27121-9. Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM. PMID: 18687682.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    66. Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. J Am Chem Soc. 2008 May 21; 130(20):6479-87. Koti Ainavarapu SR, Wiita AP, Dougan L, Uggerud E, Fernandez JM. PMID: 18433129.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    67. A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding. J Am Chem Soc. 2008 Jan 16; 130(2):436-7. Ainavarapu SR, Wiita AP, Huang HH, Fernandez JM. PMID: 18088123.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    68. Dwell time analysis of a single-molecule mechanochemical reaction. Langmuir. 2008 Feb 19; 24(4):1356-64. Szoszkiewicz R, Ainavarapu SR, Wiita AP, Perez-Jimenez R, Sanchez-Ruiz JM, Fernandez JM. PMID: 17999545.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    69. Probing the chemistry of thioredoxin catalysis with force. Nature. 2007 Nov 01; 450(7166):124-7. Wiita AP, Perez-Jimenez R, Walther KA, Gräter F, Berne BJ, Holmgren A, Sanchez-Ruiz JM, Fernandez JM. PMID: 17972886.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    70. Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys J. 2007 Jan 01; 92(1):225-33. Ainavarapu SR, Brujic J, Huang HH, Wiita AP, Lu H, Li L, Walther KA, Carrion-Vazquez M, Li H, Fernandez JM. PMID: 17028145.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    71. Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7222-7. Wiita AP, Ainavarapu SR, Huang HH, Fernandez JM. PMID: 16645035.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    72. Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners. Biochemistry. 2002 Jun 11; 41(23):7344-9. Kipp RA, Case MA, Wist AD, Cresson CM, Carrell M, Griner E, Wiita A, Albiniak PA, Chai J, Shi Y, Semmelhack MF, McLendon GL. PMID: 12044166.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
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