Arun Wiita, MD, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-514-6238
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    Collapse Biography 
    Collapse Education and Training
    Princeton UniversityA.B.2002Chemistry
    Columbia UniversityMD/PhD2009Medicine/Biophysics
    UCSFResidency2012Laboratory Medicine
    UCSFPost-doc2014Pharmaceutical Chemistry
    Collapse Awards and Honors
    Gabrielle's Angels Foundation for Cancer Research2017Janet Rowley Memorial Medical Research Award
    NIH Director's Common Fund2016New Innovator Award (DP2)
    Doris Duke Charitable Foundation2016Clinical Scientist Development Award
    Damon Runyon Cancer Research Foundation2015Dale Frey Breakthrough Award
    UCSF-American Cancer Society2015Individual Research Award
    NIH-NCI2014  - 2019K08 Mentored Clinical Scientist Award
    Damon Runyon Cancer Research Foundation2012  - 2014Post-doctoral Fellowship
    Columbia University2008Dean's Award for Excellence in Research (top PhD thesis prize)

    Collapse Overview 
    Collapse Overview
    My research laboratory spans a number of areas within genomics, proteomics, and hematologic malignancies. One major area of research involves the use of targeted, quantitative proteomics to answer important biological questions in myeloma and B-cell leukemia. We are particularly interested in questions related to translational regulation after cancer therapy as well as how clinically-relevant genomic alterations result in phenotypic changes at the level of the proteome. Furthermore, my group includes the UCSF Stephen and Nancy Grand Multiple Myeloma Translational Initiative Laboratory. In this role, we collaborate with industry and academic partners to advance preclinical evaluation of novel myeloma therapeutics using a suite of in vitro and in vivo approaches.

    In my clinical work, I am Assistant Director of the UCSF Clinical Cytogenetics laboratory. In this role, I interpret molecular genetic testing for the prenatal and postnatal diagnosis of microdeletion and microduplication syndromes. In this area we have translational interests in emerging technologies for determination of DNA copy number variation, integration of single-nucleotide variants and CNV interpretation, and cell-free DNA for prenatal testing. In my research laboratory we are also using quantitative proteomics to evaluate the role of protein homeostasis in determining the phenotypic effects of CNVs, as well using CRISPR/Cas9 genome engineering to generate new functional models of syndromic CNVs.

    Collapse Research 
    Collapse Research Activities and Funding
    ClinTAD: A Tool for Improving Clinical CNV Interpretation
    NIH R03HD105804Aug 3, 2021 - Jul 31, 2023
    Role: Principal Investigator
    Structural Surfaceomics: A Strategy for Immunotherapy Target Discovery
    NIH R21CA263229Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Immuno Oncology Product for Multiple Myeloma: g-NK Cellular Therapy to Optimize Monoclonal Antibody Efficacy in Treating Multiple
    NIH R43CA235786May 15, 2019 - Feb 29, 2020
    Role: Co-Principal Investigator
    Exploiting myeloma proteome remodeling to extend proteasome inhibitor efficacy
    NIH R01CA226851Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    In vivo monitoring of oxidative protein folding through time-resolved quantitative mass spectrometry
    NIH DP2GM123500Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Global Assessment of Myeloma Response to Chemotherapy
    NIH K08CA184116Sep 16, 2014 - Aug 31, 2019
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network. Biol Open. 2021 Sep 17. Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J. PMID: 34533192.
      View in: PubMed   Mentions:
    2. FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma. Blood Adv. 2021 08 10; 5(15):3021-3031. Bigley AB, Spade S, Agha NH, Biswas S, Tang S, Malik MH, Dai L, Masoumi S, Patiño-Escobar B, Hale M, DiPierro G, Martell R, Hann B, Shah N, Wiita AP, Liu X. PMID: 34357379.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2021 Apr; 592(7852):E3. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33712811.
      View in: PubMed   Mentions: 1     Fields:    
    4. Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. Cancer Discov. 2021 Aug; 11(8):2032-2049. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. PMID: 33727310.
      View in: PubMed   Mentions: 2     Fields:    
    5. A Guide to Using ClinTAD for Interpretation of DNA Copy Number Variants in the Context of Topologically Associated Domains. Curr Protoc Hum Genet. 2020 12; 108(1):e106. Spector JD, Wiita AP. PMID: 33170544.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Phase II Study of Daratumumab in Combination with Azacitidine and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Daratumumab: Darazadex. Blood. 2020 Nov 5; 136(Supplement 1):27-28. Kambhampati KS, Wong WS, Martin MT, Wolf WJ, Choudhry CP, Karlon KW, Wiita WA, Shah SN. .
      View in: Publisher Site   Mentions:
    7. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2020 12; 588(7838):491-497. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33149299.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 33093202.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    9. MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309. Dietrich DA, Burnett BC, Martin MT, Wiita WA, Roybal RK, Eyquem EJ. .
      View in: Publisher Site   Mentions:
    10. Variants of uncertain significance in prenatal microarrays: a retrospective cohort study. BJOG. 2021 01; 128(2):431-438. Mardy AH, Wiita AP, Wayman BV, Drexler K, Sparks TN, Norton ME. PMID: 32702189.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 04. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586.
      View in: PubMed   Mentions:
    12. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 07; 583(7818):845-851. Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. PMID: 32699415.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi. Am J Surg Pathol. 2020 06; 44(6):849-858. Han LM, Grenert JP, Wiita AP, Quinn M, Fujimoto VY, Rabban JT. PMID: 32205485.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):e20547-e20547. Kambhampati KS, Wen WK, Sung SV, Wong WS, Martin MT, Wolf WJ, Shah SN, Wiita WA. .
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    16. Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Nat Commun. 2020 04 22; 11(1):1931. Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP. PMID: 32321912.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020 03; 579(7799):427-432. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. PMID: 32132707.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    18. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Leukemia. 2020 10; 34(10):2754-2765. Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP. PMID: 32123307.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    20. Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancer. Adv Exp Med Biol. 2020; 1243:147-162. Kambhampati S, Wiita AP. PMID: 32297217.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. X-linked duplication copy number variation in a familial overgrowth condition. Am J Med Genet C Semin Med Genet. 2019 12; 181(4):644-649. Ha TK, Mardy AH, Beleford D, Spanier A, Wayman BV, Penon-Portmann M, Wiita AP, Shieh JT. PMID: 31762227.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology. Blood. 2019 Nov 13; 134(Supplement_1):1803-1803. Ferguson FI, Lin LY, Tuomivaara TS, Wolf WJ, Martin MT, Wong WS, Shah SN, Driessen DC, Van Ness VB, Wiita WA. .
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    23. Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation. Blood. 2019 Nov 13; 134(Supplement_1):3944-3944. Chan CL, Murakami MM, Caesar CR, Hurtz HC, Kume KK, Sadras ST, Shojaee SS, Pölönen PP, Ugale UA, Lee LJ, Cosgun CK, Geng GH, Heinäniemi HM, Lohi LO, Wiita WA, Izraeli IS, Weinstock WD, Müschen MM. .
      View in: Publisher Site   Mentions:
    24. In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies. Blood. 2019 Nov 13; 134(Supplement_1):1337-1337. Nix NM, Lin LY, Geng GH, Marcoulis MM, Phojanakong PP, Wang WD, Steri SV, Whitman WJ, Bapat BS, Stieglitz SE, Deucher DA, White WK, Hann HB, Wiita WA. .
      View in: Publisher Site   Mentions:
    25. Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis. Blood. 2019 Nov 13; 134(Supplement_1):2782-2782. Lee LJ, Xiao XG, Cosgun CK, Geng GH, Ma MN, Chan CL, Kume KK, Nix NM, Chen CZ, Chen CC, Chen CJ, Khairnar KV, Wiita WA, Thomas-Tikhonenko TA, Farzan FM, Diamond DM, Jung JJ, Vaidehi VN, Müschen MM. .
      View in: Publisher Site   Mentions:
    26. Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Blood Adv. 2019 11 12; 3(21):3214-3227. Lin YT, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP. PMID: 31698452.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    27. DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia. 2020 03; 34(3):938-941. Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP. PMID: 31595037.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e76. Sarin SV, Yu YK, Sirota SM, Wiita WA. .
      View in: Publisher Site   Mentions:
    29. DNA methyltransferase inhibitors upregulate CD38 expression and enhance daratumumab efficacy in multiple myeloma. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e144-e145. Choudhry CP, Mariano MM, Geng GH, Wiita WA. .
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    30. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. PMID: 31182586.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    31. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. MAbs. 2019 May/Jun; 11(4):639-652. Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S. PMID: 30698484.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains. J Hum Genet. 2019 May; 64(5):437-443. Spector JD, Wiita AP. PMID: 30765865.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. 880: Variants of uncertain significance in prenatal microarrays. American Journal of Obstetrics and Gynecology. 2019 Jan 1; 220(1):s572-s573. Mardy MA, Sparks ST, Wiita WA, Drexler DK, Wayman WB, Nadel NA, Norton NM. .
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    34. Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001. Oncotarget. 2018 Dec 28; 9(102):37700-37714. Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A. PMID: 30701025.
      View in: PubMed   Mentions: 7     Fields:    
    35. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Ramkumar RP, Leong LJ, Seyler SM, Georgoulis GS, Hyrenius Wittsten HA, Choudhry CP, Roybal RK, Wiita WA, Kampmann KM. .
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    36. IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation. Blood. 2018 Nov 29; 132(Supplement 1):552-552. Lee LJ, Geng GH, Dinson DD, Xiao XG, Cosgun CK, Chan CL, Chen CZ, Farzan FM, Jung JJ, Wiita WA, Muschen MM. .
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    37. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):3212-3212. Ferguson FI, Lam LC, Mariano MM, Wang WD, Phojanakong PP, Toumivaara TS, Shao SH, Hann HB, Gestwicki GJ, Wiita WA. .
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    38. DNA Methyltransferase Inhibitors Increase Expression of CD38 and Enhance Daratumumab Efficacy in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):5618-5618. Choudhry CP, Mariano MM, Wiita WA. .
      View in: Publisher Site   Mentions:
    39. Integrating Phosphoproteomics and Transcriptional Classifiers Reveals "Hidden Signaling" in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects. Blood. 2018 Nov 29; 132(Supplement 1):469-469. Lin LY, Way WG, Mariano MM, Marcoulis MM, Ferguson FI, Greene GC, Wiita WA. .
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    40. Fine Needle Aspiration is an Effective Method for Cell Surface Proteomics: Towards a Personalized Cancer Surfaceome. Journal of the American Society of Cytopathology. 2018 Sep 1; 7(5):s86-s87. Whitman WJ, Ng ND, Nix NM, Leung LK, Balassanian BR, Wiita WA. .
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    41. Seeking Convergence and Cure with New Myeloma Therapies. Trends Cancer. 2018 08; 4(8):567-582. Choudhry P, Galligan D, Wiita AP. PMID: 30064664.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):8034-8034. Buelow BB, Choudry CP, Clarke CS, Dang DK, Davison DL, Force Aldred FS, Harris HK, Pratap PP, Pham PD, Rangaswamy RU, Schellenberger SU, Shah SN, Trinklein TN, Ugamraj UH, Wiita WA, Van Schooten VW. .
      View in: Publisher Site   Mentions:
    43. Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. 2018 07; 103(7):1218-1228. Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. PMID: 29622655.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. PMID: 29476136.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    45. Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 2018 Feb 10; 36(5_suppl):60-60. Buelow BB, Choudhry CP, Clarke CS, Dang DK, Davison DL, Force Aldred FS, Harris HK, Pham PD, Pratap PP, Rangaswamy RU, Schellenberger SU, Shah SN, Trinklein TN, Ugamraj UH, Wiita WA, Van Schooten VW. .
      View in: Publisher Site   Mentions:
    46. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. PMID: 29212016.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    47. The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma. . 2017 11; 16(11):2375-2386. Le Moigne R, Aftab BT, Djakovic S, Dhimolea E, Valle E, Murnane M, King EM, Soriano F, Menon MK, Wu ZY, Wong ST, Lee GJ, Yao B, Wiita AP, Lam C, Rice J, Wang J, Chesi M, Bergsagel PL, Kraus M, Driessen C, Kiss von Soly S, Yakes FM, Wustrow D, Shawver L, Zhou HJ, Martin TG, Wolf JL, Mitsiades CS, Anderson DJ, Rolfe M. PMID: 28878026.
      View in: PubMed   Mentions:
    48. Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics. Cell Syst. 2017 06 28; 4(6):636-644.e9. Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP. PMID: 28578850.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    49. Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 2017 May 20; 35(15_suppl):8017-8017. Buelow BB, Pham PD, Clarke CS, Force Aldred FS, Dang DK, Pratap PP, Ugamraj UH, Harris HK, Trinklein TN, Schellenberger SU, Wiita WA, Van Schooten VW, Buelow BB. .
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    50. False negative fetal cell free DNA screening for microdeletion syndromes in the presence of an unbalanced translocation involving monosomy 4p. Prenat Diagn. 2017 04; 37(4):420-422. Qi Z, Madaan S, Chetty S, Yu J, Wiita AP. PMID: 28207935.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Hijacking Myeloma Metabolism to Target Cytotoxic Chemotherapy to Malignant Plasma Cells With Decreased Bone Marrow Toxicity. Clinical Lymphoma Myeloma & Leukemia. 2017 Feb 1; 17(1):e53. Wiita WA, Liu LH, Lam LC, Jandeleit JB, Fischer FW, Koller KK, Hann HB. .
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    52. CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate. Blood. 2016 Dec 2; 128(22):384-384. Sherbenou SD, Aftab AB, Su SY, Behrens BC, Wiita WA, Logan LA, Acosta-Alvear AD, Hann HB, Walter WP, Wu WX, Atkinson AJ, Wolf WJ, Martin MT, Liu LB. .
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    53. Tofacitinib Reverses Growth Promoting Effects of the Bone Marrow Stromal Environment Though Inhibition of JAK1/STAT3 Signaling in Multiple Myeloma. Blood. 2016 Dec 2; 128(22):2098-2098. Lam LC, Murnane MM, Smith SG, Taunton TJ, Aftab AB, Wiita WA. .
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    54. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 12 01; 126(12):4640-4653. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. PMID: 27841764.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    55. False positive cell free DNA screening for microdeletions due to non-pathogenic copy number variants. Prenat Diagn. 2016 Jun; 36(6):584-6. Mather CA, Qi Z, Wiita AP. PMID: 27061292.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    57. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500.
      View in: PubMed   Mentions: 36     Fields:    
    58. Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma. Blood. 2015 Dec 3; 126(23):503-503. Murnane MM, Dhimolea DE, Li LR, Bariteau BM, Wheeler WD, Akhurst AR, Logan LA, Munster MP, Wiita WA, Martin MT, Wolf WJ, Liu LJ, Mitsiades MC, Aftab AB. .
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    59. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7594-9. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. PMID: 24821784.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    60. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. PMID: 24443746.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimals
    61. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods Enzymol. 2014; 544:327-58. Wiita AP, Seaman JE, Wells JA. PMID: 24974296.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    62. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    63. Evaluation of Glutamate Dehydrogenase Immunoassay Screening with Toxin Confirmation for the Diagnosis of Clostridium difficile Infection. Lab Medicine. 2013 Aug 1; 44(3):e65-e71. Miller MS, Wiita WA, Wright WC, Reyes RH, Liu LC. .
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    64. Longitudinal management with crossmatch-compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes (CME). Transfusion. 2012 Oct; 52(10):2146-54. Wiita AP, Nambiar A. PMID: 23113654.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    65. Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis. Transpl Infect Dis. 2012 Jun; 14(3):248-58. Wiita AP, Roubinian N, Khan Y, Chin-Hong PV, Singer JP, Golden JA, Miller S. PMID: 22385394.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    66. Clinical application of high throughput molecular screening techniques for pharmacogenomics. Pharmgenomics Pers Med. 2011; 4:109-21. Wiita AP, Schrijver I. PMID: 23226057.
      View in: PubMed   Mentions:
    67. Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology. 2009 Dec 1; 16(12):1331-1331. Perez-Jimenez PR, Li LJ, Kosuri KP, Sanchez-Romero SI, Wiita WA, Rodriguez-Larrea RD, Chueca CA, Holmgren HA, Miranda-Vizuete MA, Becker BK, Cho CS, Beckwith BJ, Gelhaye GE, Jacquot JJ, Gaucher GE, Sanchez-Ruiz SJ, Berne BB, Fernandez FJ. .
      View in: Publisher Site   Mentions:
    68. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol. 2009 Aug; 16(8):890-6. Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Gaucher E, Sanchez-Ruiz JM, Berne BJ, Fernandez JM. PMID: 19597482.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    69. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. J Biol Chem. 2008 Oct 03; 283(40):27121-9. Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM. PMID: 18687682.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    70. Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. J Am Chem Soc. 2008 May 21; 130(20):6479-87. Koti Ainavarapu SR, Wiita AP, Dougan L, Uggerud E, Fernandez JM. PMID: 18433129.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    71. A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding. J Am Chem Soc. 2008 Jan 16; 130(2):436-7. Ainavarapu SR, Wiita AP, Huang HH, Fernandez JM. PMID: 18088123.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    72. Dwell time analysis of a single-molecule mechanochemical reaction. Langmuir. 2008 Feb 19; 24(4):1356-64. Szoszkiewicz R, Ainavarapu SR, Wiita AP, Perez-Jimenez R, Sanchez-Ruiz JM, Fernandez JM. PMID: 17999545.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    73. Probing the chemistry of thioredoxin catalysis with force. Nature. 2007 Nov 01; 450(7166):124-7. Wiita AP, Perez-Jimenez R, Walther KA, Gräter F, Berne BJ, Holmgren A, Sanchez-Ruiz JM, Fernandez JM. PMID: 17972886.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    74. Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys J. 2007 Jan 01; 92(1):225-33. Ainavarapu SR, Brujic J, Huang HH, Wiita AP, Lu H, Li L, Walther KA, Carrion-Vazquez M, Li H, Fernandez JM. PMID: 17028145.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    75. Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7222-7. Wiita AP, Ainavarapu SR, Huang HH, Fernandez JM. PMID: 16645035.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    76. Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners. Biochemistry. 2002 Jun 11; 41(23):7344-9. Kipp RA, Case MA, Wist AD, Cresson CM, Carrell M, Griner E, Wiita A, Albiniak PA, Chai J, Shi Y, Semmelhack MF, McLendon GL. PMID: 12044166.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
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