Arun Wiita, MD, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
Address1450 Third Street, #265
San Francisco CA 94158
Phone415-514-6238
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    Collapse Biography 
    Collapse Education and Training
    Princeton UniversityA.B.2002Chemistry
    Columbia UniversityMD/PhD2009Medicine/Biophysics
    UCSFResidency2012Laboratory Medicine
    UCSFPost-doc2014Pharmaceutical Chemistry
    Collapse Awards and Honors
    Gabrielle's Angels Foundation for Cancer Research2017Janet Rowley Memorial Medical Research Award
    NIH Director's Common Fund2016New Innovator Award (DP2)
    Doris Duke Charitable Foundation2016Clinical Scientist Development Award
    Damon Runyon Cancer Research Foundation2015Dale Frey Breakthrough Award
    UCSF-American Cancer Society2015Individual Research Award
    NIH-NCI2014  - 2019K08 Mentored Clinical Scientist Award
    Damon Runyon Cancer Research Foundation2012  - 2014Post-doctoral Fellowship
    Columbia University2008Dean's Award for Excellence in Research (top PhD thesis prize)

    Collapse Overview 
    Collapse Overview
    My research laboratory spans a number of areas within genomics, proteomics, and hematologic malignancies. One major area of research involves the use of targeted, quantitative proteomics to answer important biological questions in myeloma and B-cell leukemia. We are particularly interested in questions related to translational regulation after cancer therapy as well as how clinically-relevant genomic alterations result in phenotypic changes at the level of the proteome. Furthermore, my group includes the UCSF Stephen and Nancy Grand Multiple Myeloma Translational Initiative Laboratory. In this role, we collaborate with industry and academic partners to advance preclinical evaluation of novel myeloma therapeutics using a suite of in vitro and in vivo approaches.

    In my clinical work, I am Assistant Director of the UCSF Clinical Cytogenetics laboratory. In this role, I interpret molecular genetic testing for the prenatal and postnatal diagnosis of microdeletion and microduplication syndromes. In this area we have translational interests in emerging technologies for determination of DNA copy number variation, integration of single-nucleotide variants and CNV interpretation, and cell-free DNA for prenatal testing. In my research laboratory we are also using quantitative proteomics to evaluate the role of protein homeostasis in determining the phenotypic effects of CNVs, as well using CRISPR/Cas9 genome engineering to generate new functional models of syndromic CNVs.

    Collapse Research 
    Collapse Research Activities and Funding
    ClinTAD: A Tool for Improving Clinical CNV Interpretation
    NIH R03HD105804Aug 3, 2021 - Jul 31, 2023
    Role: Principal Investigator
    Structural Surfaceomics: A Strategy for Immunotherapy Target Discovery
    NIH R21CA263229Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Immuno Oncology Product for Multiple Myeloma: g-NK Cellular Therapy to Optimize Monoclonal Antibody Efficacy in Treating Multiple
    NIH R43CA235786May 15, 2019 - Feb 29, 2020
    Role: Co-Principal Investigator
    Exploiting myeloma proteome remodeling to extend proteasome inhibitor efficacy
    NIH R01CA226851Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    In vivo monitoring of oxidative protein folding through time-resolved quantitative mass spectrometry
    NIH DP2GM123500Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Global Assessment of Myeloma Response to Chemotherapy
    NIH K08CA184116Sep 16, 2014 - Aug 31, 2019
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abstract PR008: Modulating the PPAR? pathway to augment NECTIN4-targeting chimeric antigen receptor (CAR) T cell therapy. Clinical Cancer Research. 2024 May 17; 30(10_Supplement):pr008-pr008. Chang CK, Delavan DH, Zhu ZJ, Kasap KC, Yip YE, Lodha LR, Liao LS, Porten PS, Friedlander FT, Koshkin KV, Feng FF, Wiita WA, Lee LJ, Chu CC, Chou CJ. .
      View in: Publisher Site   Mentions:
    2. MP65-18 IDENTIFICATION OF MOLECULAR TARGETS IN BLADDER CANCER VARIANTS USING SINGLE-CELL ANALYSIS. Journal of Urology. 2024 May 1; 211(5S):e1084. Yang YH, Song SH, Allegakoen AP, Lu LK, Yip YE, Hui HK, Chang CK, Kasap KC, Gayle GJ, Stohr SB, Meng MM, Wiita WA, Ding DC, Chou CJ, Porten PS, Huang HF. .
      View in: Publisher Site   Mentions:
    3. Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy. Neurol Genet. 2024 Apr; 10(2):e200142. Leng K, Cadwell CR, Devine WP, Tihan T, Qi Z, Singhal NS, Glenn OA, Kamiya S, Wiita AP, Berger AC, Shieh JT, Titus EW, Paredes MF, Upadhyay V. PMID: 38586598; PMCID: PMC10997208.
      View in: PubMed   Mentions:
    4. Abstract 3907: Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types. Cancer Research. 2024 Mar 22; 84(6_Supplement):3907-3907. Kwok KD, Stevers SN, Nejo NT, Chen CL, Etxeberria EI, Jung JJ, Okada OK, Cove CM, Lakshmanachetty LS, Gallus GM, Barpanda BA, Hong HC, Chan CG, Wu WS, Ramos RE, Yamamichi YA, Liu LJ, Watchmaker WP, Ogino OH, Saijo SA, Du DA, Grishanina GN, Woo WJ, Diaz DA, Chang CS, Phillips PJ, Wiita WA, Klebanoff KC, Costello CJ, Okada OH. .
      View in: Publisher Site   Mentions:
    5. Abstract 6405: Identification of molecular targets in bladder cancer variants using single-cell analysis. Cancer Research. 2024 Mar 22; 84(6_Supplement):6405-6405. Yang YH, Song SH, Allegakoen AP, Lu LK, Yip YE, Hui HK, Chang CK, Kasap KC, Gayle GJ, Stohr SB, Wiita WA, Ding DC, Meng MM, Chou CJ, Porten PS, Huang HF. .
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    6. Abstract 4653: Unraveling the vulnerabilities of targeted therapy-tolerant persister cells in NSCLC. Cancer Research. 2024 Mar 22; 84(6_Supplement):4653-4653. Kim KD, Kuchenov KD, Zaman ZA, Bennett BN, Ramos RE, Nakamura NK, Wiita WA, Bandyopadhyay BS, Bivona BT. .
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    7. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Sci Rep. 2024 03 16; 14(1):6362. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 38493204; PMCID: PMC10944514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Alternative target recognition elements for chimeric antigen receptor (CAR) T cells: beyond standard antibody fragments. Cytotherapy. 2024 Mar 02. Nix MA, Wiita AP. PMID: 38466264.
      View in: PubMed   Mentions: 1     Fields:    
    9. CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma. Clin Cancer Res. 2024 03 01; 30(5):1009-1021. Wadhwa A, Wang S, Patiño-Escobar B, Bidkar AP, Bobba KN, Chan E, Meher N, Bidlingmaier S, Su Y, Dhrona S, Geng H, Sarin V, VanBrocklin HF, Wilson DM, He J, Zhang L, Steri V, Wong SW, Martin TG, Seo Y, Liu B, Wiita AP, Flavell RR. PMID: 38109209; PMCID: PMC10905524.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells. bioRxiv. 2024 Feb 28. Kasap C, Izgutdina A, Patiño-Escobar B, Kang A, Chilakapati N, Akagi N, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alós D, Sobh A, Dupéré-Richer D, Wicaksono G, Kawehi Kelii KM, Dalal R, Ramos E, Vijayanarayanan A, Salangsang F, Phojanakong P, Serrano JAC, Zakraoui O, Tariq I, Steri V, Shanmugam M, Boise LH, Kortemme T, Stieglitz E, Licht JD, Karlon WJ, Barwick BG, Wiita AP. PMID: 38463958; PMCID: PMC10925123.
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    11. Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Cell Stem Cell. 2024 03 07; 31(3):421-432.e8. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ. PMID: 38382530; PMCID: PMC10939828.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Preclinical Development and Characterization of Humanized Anti-CD72 Nanobody Chimeric Antigen Receptor T Cells for B Cell Malignancies. Transplantation and Cellular Therapy. 2024 Feb 1; 30(2):s174-s175. Temple TW, Izgutdina IA, Nix NM, Huang HB, Phojanakong PP, Serrano SJ, Salangsang SF, Steri SV, Xirenayi XS, Stieglitz SE, Wiita WA. .
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    13. Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy. bioRxiv. 2024 Jan 25. Leng K, Cadwell CR, Patrick Devine W, Tihan T, Qi Z, Singhal N, Glenn O, Kamiya S, Wiita A, Berger A, Shieh JT, Titus EW, Paredes MF, Upadhyay V. PMID: 38328093; PMCID: PMC10849466.
      View in: PubMed   Mentions:
    14. Affinity Matured CD72 CAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models. Blood. 2023 Nov 28; 142(Supplement 1):2068. Izgutdina IA, Temple TW, Nix NM, Geng GH, Ramos RE, Naik NA, Larson LR, Salangsang SF, Phojanakong PP, Serrano SJ, Zakraoui ZO, Tariq TI, Maus MM, Steri SV, Wiita WA. .
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    15. Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma. Blood. 2023 Nov 28; 142(Supplement 1):465. Kasap KC, Izgutdina IA, Escobar EB, Lin LY, Geng GH, Wicaksono WG, Dupere-Richer DD, Ramos RE, Barpanda BA, Vijayanarayanan VA, Salangsang SF, Phojanakong PP, Serrano SJ, Steri SV, Karlon KW, Shanmugam SM, Boise BL, Barwick BB, Licht LJ, Wiita WA. .
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    16. Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies. J Immunother Cancer. 2023 11 24; 11(11). Temple WC, Nix MA, Naik A, Izgutdina A, Huang BJ, Wicaksono G, Phojanakong P, Serrano JAC, Young EP, Ramos E, Salangsang F, Steri V, Xirenayi S, Hermiston M, Logan AC, Stieglitz E, Wiita AP. PMID: 38007238; PMCID: PMC10680002.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. IMMU-16. PUBLIC TUMOR-WIDE NEOANTIGENS DERIVED FROM CLONAL ABERRANT SPLICING EVENTS DRIVE TUMOR-SPECIFIC T-CELL RESPONSES. Neuro-Oncology. 2023 Nov 10; 25(Supplement_5):v144-v145. Kwok KD, Stevers SN, Nejo NT, Jung JJ, Chen CL, Lakshmanachetty LS, Etxeberria EI, Gallus GM, Yamamichi YA, Ramos RE, Hong HC, Colton CM, Chan CG, Du DA, Woo WJ, Wiita WA, Klebanoff KC, Costello CJ, Okada OH. .
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    18. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. bioRxiv. 2023 Nov 02. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 37961484; PMCID: PMC10634890.
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    19. O-77 Molecular imaging and radiopharmaceutical therapy of Multiple Myeloma targeting CD46 using 89Zr and 225Ac-YS5. Nuclear Medicine and Biology. 2023 Nov 1; 126:108473. Wadhwa WA, Wang WS, Escobar EB, Bidkar BA, Bobba BK, Meher MN, Dhrona DS, Wong WS, Wilson WD, VanBrocklin VH, Seo SY, Liu LB, Wiita WA, Flavell FR. .
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    20. Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target. Nat Cancer. 2023 Nov; 4(11):1592-1609. Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano JAC, Salangsang F, Phojanakong P, McMillan M, Gavallos V, Leavitt AD, Logan AC, Rooney CM, Eyquem J, Sinz A, Huang BJ, Stieglitz E, Smith CC, Moritz RL, Sidhu SS, Huang L, Wiita AP. PMID: 37904046; PMCID: PMC10663162.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens. bioRxiv. 2023 Oct 20. Kwok DW, Stevers NO, Nejo T, Chen LH, Etxeberria I, Jung J, Okada K, Cove MC, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Wu SH, Ramos E, Yamamichi A, Liu J, Watchmaker P, Ogino H, Saijo A, Du A, Grishanina N, Woo J, Diaz A, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. PMID: 37904942; PMCID: PMC10614978.
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    22. Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells. Nat Struct Mol Biol. 2023 10; 30(10):1561-1570. Gökbuget D, Lenshoek K, Boileau RM, Bayerl J, Huang H, Wiita AP, Laird DJ, Blelloch R. PMID: 37696959.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. P985: CLL-1 IS AN ADOPTIVE IMMUNOTHERAPY TARGET IN JUVENILE MYELOMONOCYTIC LEUKEMIA. HemaSphere. 2023 Aug 1; 7(Suppl):e40333db. Huebner HJ, Xirenayi XS, Rivera RJ, Escobar EB, Lee LA, Mandal MK, Diaz-Flores DE, Wiita WA, Stieglitz SE. .
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    24. Overcoming proteasome inhibitor resistance in the immunotherapy era. Trends Pharmacol Sci. 2023 08; 44(8):507-518. Patiño-Escobar B, Talbot A, Wiita AP. PMID: 37344251.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion. Sci Rep. 2023 05 11; 13(1):7689. Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP. PMID: 37169815; PMCID: PMC10175260.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    26. SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling. bioRxiv. 2023 Mar 26. Tuomivaara ST, Teo CF, Jan YN, Jan LY, Wiita AP. PMID: 36993417; PMCID: PMC10055316.
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    27. "Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome. J Vis Exp. 2023 03 24; (193). Naik A, Srivastava S, Wiita AP. PMID: 37036222.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. Cytomegalovirus seropositivity is associated with improved responses to CD38 monoclonal antibody therapies in multiple myeloma: A single-centre retrospective study. Br J Haematol. 2023 06; 201(5):935-939. Ge AY, Huang CY, Banerjee R, Knoche J, Chung A, Arora S, Martin TG, Wolf J, Wong SW, Wiita AP, Shah N. PMID: 36846905.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-ß2 As an Immunotherapeutic Target. Blood. 2022 Nov 15; 140(Supplement 1):867-868. Mandal MK, Wicaksono WG, Yu YC, Adams AJ, Hoopmann HM, Temple TW, Escobar EB, Gorelik GM, Ihling IC, Nix NM, Naik NA, Ramos RE, Kasap KC, Steri SV, Serrano SJ, Salangsang SF, Phojanakong PP, McMillan MM, Gavallos GV, Leavitt LA, Sinz SA, Huang HB, Stieglitz SE, Smith SC, Moritz MR, Sidhu SS, Huang HL, Wiita WA. .
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    30. Integrating Transcriptomics and Proteomics for the Discovery of Novel Antigen Targets on Surface of Malignant Plasma Cells Amenable for Chimeric Antigen Receptor-T (CAR-T) Cell Approach in the Treatment of Patients with Relapsed/Refractory Multiple Myeloma. Blood. 2022 Nov 15; 140(Supplement 1):7094-7095. Talbot TA, Weill WS, Fox FE, Meunier ML, Appé AG, Marijon MC, Behdenna BA, Wiita WA, Nordor NA, Eyquem EJ. .
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    31. Humanized Nanobody Anti-CD72 CAR-T Cells Efficiently Eliminate B-Cell Malignancies Via Improved Affinity for CD72 but Induce Persistent Antigen Downregulation In Vivo. Blood. 2022 Nov 15; 140(Supplement 1):7394-7395. Temple TW, Wicaksono WG, Naik NA, Izgutdina IA, Nix NM, Young YE, Phojanakong PP, Serrano SJ, Steri SV, Salangsang SF, Wiita WA. .
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    32. Profiling the Cell Surface of MPN Blast Phase Suggests Unique Biology and Therapeutic Targets. Blood. 2022 Nov 15; 140(Supplement 1):6735-6736. Ramos RE, Wiita WA. .
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    33. Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance. Cell Stress. 2022 Nov; 6(11):89-92. Patiño-Escobar B, Ferguson ID, Wiita AP. PMID: 36311892; PMCID: PMC9558132.
      View in: PubMed   Mentions: 2  
    34. 010 CD72 NANOBODY CAR-T CELLS HAVE POTENT ANTITUMOR EFFICACY IN B CELL MALIGNANCIES. Leukemia Research. 2022 Oct 1; 121:s8. Temple TW, Nix NM, Wicaksono WG, Wang WD, Phojanakong PP, Steri SV, Hann HB, Hermiston HM, Wiita WA. .
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    35. Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma. Sci Adv. 2022 09 30; 8(39):eabq5575. Sharma A, Nair R, Achreja A, Mittal A, Gupta P, Balakrishnan K, Edgar CL, Animasahun O, Dwivedi B, Barwick BG, Gupta VA, Matulis SM, Bhasin M, Lonial S, Nooka AK, Wiita AP, Boise LH, Nagrath D, Shanmugam M. PMID: 36170375; PMCID: PMC9519052.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. P-100: Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma. Clinical Lymphoma Myeloma & Leukemia. 2022 Aug 1; 22:s90. Ferguson FI, Lin LT, Lam LC, Shao SH, Tharp TK, Van Ness VB, Gestwicki GJ, Wiita WA. .
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    37. ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells. EMBO J. 2022 09 01; 41(17):e109205. Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM. PMID: 35880301; PMCID: PMC9434103.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    38. Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma. Cell Chem Biol. 2022 08 18; 29(8):1288-1302.e7. Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, Hann B, Driessen C, Van Ness B, Gestwicki JE, Wiita AP. PMID: 35853457; PMCID: PMC9434701.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nat Commun. 2022 07 15; 13(1):4121. Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD, Mullins RD, Eyquem J, Wells JA, Wiita AP. PMID: 35840578; PMCID: PMC9287322.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    40. Secretory autophagy maintains proteostasis upon lysosome inhibition. J Cell Biol. 2022 06 06; 221(6). Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J, Leidal AM. PMID: 35446347; PMCID: PMC9036093.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    41. Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma. Blood. 2021 Nov 5; 138(Supplement 1):2648-2648. Choudhry CP, Gugliemini GO, Geng GH, Sarin SV, Sarah SL, Lin LY, Paranjape PN, Ramkumar RP, Marcoulis MM, Wang WD, Phojanakong PP, Steri SV, Hann HB, Kampmann KM, Wiita WA. .
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    42. Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma. Blood. 2021 Nov 5; 138(Supplement 1):1611-1611. Sharma SA, Achreja AA, Nair NR, Gupta GP, Edgar EC, Animasahun AO, Mittal MA, Dwivedi DB, Bhasin BM, Gupta GV, Barwick BB, Matulis MS, Lonial LS, Boise BL, Jaye JD, Wiita WA, Nooka NA, Nagrath ND, Shanmugam SM. .
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    43. CD72 Nanobody-Based CAR-T Cells Have Potent Anti-Tumor Efficacy in B Cell Malignancies. Blood. 2021 Nov 5; 138(Supplement 1):1717-1717. Nix NM, Temple TW, Karlon KW, Wang WD, Phojanakong PP, Steri SV, Hann HB, Wiita WA. .
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    44. GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network. Biol Open. 2021 10 15; 10(10). Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J. PMID: 34533192; PMCID: PMC8524720.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. P-103: Profiling the myeloma cell surface proteome reveals CCR10 as a potential immunotherapeutic target. Clinical Lymphoma Myeloma & Leukemia. 2021 Oct 1; 21:s94-s95. Patino-Escobar PB, Kasap KC, Ferguson FI, Hale HM, Wiita WA. .
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    46. FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma. Blood Adv. 2021 08 10; 5(15):3021-3031. Bigley AB, Spade S, Agha NH, Biswas S, Tang S, Malik MH, Dai L, Masoumi S, Patiño-Escobar B, Hale M, DiPierro G, Martell R, Hann B, Shah N, Wiita AP, Liu X. PMID: 34357379; PMCID: PMC8361460.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    47. Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2021 Apr; 592(7852):E3. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33712811.
      View in: PubMed   Mentions:    Fields:    
    48. Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. Cancer Discov. 2021 08; 11(8):2032-2049. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP. PMID: 33727310; PMCID: PMC8338785.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    49. A Guide to Using ClinTAD for Interpretation of DNA Copy Number Variants in the Context of Topologically Associated Domains. Curr Protoc Hum Genet. 2020 12; 108(1):e106. Spector JD, Wiita AP. PMID: 33170544.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Phase II Study of Daratumumab in Combination with Azacitidine and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Daratumumab: Darazadex. Blood. 2020 Nov 5; 136(Supplement 1):27-28. Kambhampati KS, Wong WS, Martin MT, Wolf WJ, Choudhry CP, Karlon KW, Wiita WA, Shah SN. .
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    51. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature. 2020 12; 588(7838):491-497. Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. PMID: 33149299; PMCID: PMC8087162.
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    52. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 33093202; PMCID: PMC7668070.
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    53. MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309. Dietrich DA, Burnett BC, Martin MT, Wiita WA, Roybal RK, Eyquem EJ. .
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    54. Variants of uncertain significance in prenatal microarrays: a retrospective cohort study. BJOG. 2021 01; 128(2):431-438. Mardy AH, Wiita AP, Wayman BV, Drexler K, Sparks TN, Norton ME. PMID: 32702189; PMCID: PMC7856034.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    55. Abstract 1630: FceR1g negative NK-cells (g-NK) enhance antibody-dependent cellular cytotoxicity and in vivo efficacy of therapeutic monoclonal antibodies against hematologic malignanices. Cancer Research. 2020 Aug 15; 80(16_Supplement):1630-1630. Bigley BA, Agha AN, Spade SS, Dipierro DG, Martell MR, Hann HB, Shah SN, Wiita WA. .
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    56. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 04. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586; PMCID: PMC7402043.
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    57. Signalling input from divergent pathways subverts B cell transformation. Nature. 2020 07; 583(7818):845-851. Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. PMID: 32699415; PMCID: PMC7394729.
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    58. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729; PMCID: PMC7362346.
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    59. Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi. Am J Surg Pathol. 2020 06; 44(6):849-858. Han LM, Grenert JP, Wiita AP, Quinn M, Fujimoto VY, Rabban JT. PMID: 32205485.
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    60. Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):e20547-e20547. Kambhampati KS, Wen WK, Sung SV, Wong WS, Martin MT, Wolf WJ, Shah SN, Wiita WA. .
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    61. Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Nat Commun. 2020 04 22; 11(1):1931. Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP. PMID: 32321912; PMCID: PMC7176739.
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    62. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020 03; 579(7799):427-432. Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. PMID: 32132707; PMCID: PMC7147832.
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    63. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Leukemia. 2020 10; 34(10):2754-2765. Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP. PMID: 32123307; PMCID: PMC7483300.
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    64. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738; PMCID: PMC7007875.
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    65. Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancer. Adv Exp Med Biol. 2020; 1243:147-162. Kambhampati S, Wiita AP. PMID: 32297217.
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    66. X-linked duplication copy number variation in a familial overgrowth condition. Am J Med Genet C Semin Med Genet. 2019 12; 181(4):644-649. Ha TK, Mardy AH, Beleford D, Spanier A, Wayman BV, Penon-Portmann M, Wiita AP, Shieh JT. PMID: 31762227.
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    67. Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology. Blood. 2019 Nov 13; 134(Supplement_1):1803-1803. Ferguson FI, Lin LY, Tuomivaara TS, Wolf WJ, Martin MT, Wong WS, Shah SN, Driessen DC, Van Ness VB, Wiita WA. .
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    68. Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation. Blood. 2019 Nov 13; 134(Supplement_1):3944-3944. Chan CL, Murakami MM, Caesar CR, Hurtz HC, Kume KK, Sadras ST, Shojaee SS, Pölönen PP, Ugale UA, Lee LJ, Cosgun CK, Geng GH, Heinäniemi HM, Lohi LO, Wiita WA, Izraeli IS, Weinstock WD, Müschen MM. .
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    69. In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies. Blood. 2019 Nov 13; 134(Supplement_1):1337-1337. Nix NM, Lin LY, Geng GH, Marcoulis MM, Phojanakong PP, Wang WD, Steri SV, Whitman WJ, Bapat BS, Stieglitz SE, Deucher DA, White WK, Hann HB, Wiita WA. .
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    70. Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis. Blood. 2019 Nov 13; 134(Supplement_1):2782-2782. Lee LJ, Xiao XG, Cosgun CK, Geng GH, Ma MN, Chan CL, Kume KK, Nix NM, Chen CZ, Chen CC, Chen CJ, Khairnar KV, Wiita WA, Thomas-Tikhonenko TA, Farzan FM, Diamond DM, Jung JJ, Vaidehi VN, Müschen MM. .
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    71. Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Blood Adv. 2019 11 12; 3(21):3214-3227. Lin YT, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP. PMID: 31698452; PMCID: PMC6855123.
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    72. DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia. 2020 03; 34(3):938-941. Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP. PMID: 31595037; PMCID: PMC7214267.
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    73. Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e76. Sarin SV, Yu YK, Sirota SM, Wiita WA. .
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    74. DNA methyltransferase inhibitors upregulate CD38 expression and enhance daratumumab efficacy in multiple myeloma. Clinical Lymphoma Myeloma & Leukemia. 2019 Oct 1; 19(10):e144-e145. Choudhry CP, Mariano MM, Geng GH, Wiita WA. .
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    75. Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies. Immunology. 2019 Jul 1; 1554-1554. Lorentsen LK, Sankaran SP, Trinklein TN, Pham PD, Schellenberger SU, Buelow BB, Boudreau BA, Choudhry CP, Clarke CS, Dang DK, Harris HK, Iyer IS, Jorgensen JB, Pratap PP, Rangaswamy RU, Ugamraj UH, Vafa VO, Wiita WA, Schooten SW, Buelow BR, Aldred AS. .
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    76. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. PMID: 31182586; PMCID: PMC6600921.
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    77. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. MAbs. 2019 May/Jun; 11(4):639-652. Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S. PMID: 30698484; PMCID: PMC6601548.
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    78. ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains. J Hum Genet. 2019 May; 64(5):437-443. Spector JD, Wiita AP. PMID: 30765865.
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    79. 880: Variants of uncertain significance in prenatal microarrays. American Journal of Obstetrics and Gynecology. 2019 Jan 1; 220(1):s572-s573. Mardy MA, Sparks ST, Wiita WA, Drexler DK, Wayman WB, Nadel NA, Norton NM. .
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    80. Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001. Oncotarget. 2018 Dec 28; 9(102):37700-37714. Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A. PMID: 30701025; PMCID: PMC6340874.
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    81. IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation. Blood. 2018 Nov 29; 132(Supplement 1):552-552. Lee LJ, Geng GH, Dinson DD, Xiao XG, Cosgun CK, Chan CL, Chen CZ, Farzan FM, Jung JJ, Wiita WA, Muschen MM. .
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    82. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):3212-3212. Ferguson FI, Lam LC, Mariano MM, Wang WD, Phojanakong PP, Toumivaara TS, Shao SH, Hann HB, Gestwicki GJ, Wiita WA. .
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    83. DNA Methyltransferase Inhibitors Increase Expression of CD38 and Enhance Daratumumab Efficacy in Multiple Myeloma. Blood. 2018 Nov 29; 132(Supplement 1):5618-5618. Choudhry CP, Mariano MM, Wiita WA. .
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    84. Integrating Phosphoproteomics and Transcriptional Classifiers Reveals "Hidden Signaling" in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects. Blood. 2018 Nov 29; 132(Supplement 1):469-469. Lin LY, Way WG, Mariano MM, Marcoulis MM, Ferguson FI, Greene GC, Wiita WA. .
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    85. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics. Blood. 2018 Nov 29; 132(Supplement 1):1926-1926. Ramkumar RP, Leong LJ, Seyler SM, Georgoulis GS, Hyrenius Wittsten HA, Choudhry CP, Roybal RK, Wiita WA, Kampmann KM. .
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    86. Fine Needle Aspiration is an Effective Method for Cell Surface Proteomics: Towards a Personalized Cancer Surfaceome. Journal of the American Society of Cytopathology. 2018 Sep 1; 7(5):s86-s87. Whitman WJ, Ng ND, Nix NM, Leung LK, Balassanian BR, Wiita WA. .
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    87. Seeking Convergence and Cure with New Myeloma Therapies. Trends Cancer. 2018 08; 4(8):567-582. Choudhry P, Galligan D, Wiita AP. PMID: 30064664; PMCID: PMC6083854.
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    88. Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):8034-8034. Buelow BB, Choudry CP, Clarke CS, Dang DK, Davison DL, Force Aldred FS, Harris HK, Pratap PP, Pham PD, Rangaswamy RU, Schellenberger SU, Shah SN, Trinklein TN, Ugamraj UH, Wiita WA, Van Schooten VW. .
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    89. Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. 2018 07; 103(7):1218-1228. Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. PMID: 29622655; PMCID: PMC6029548.
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    90. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. PMID: 29476136; PMCID: PMC5824822.
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    91. Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 2018 Feb 10; 36(5_suppl):60-60. Buelow BB, Choudhry CP, Clarke CS, Dang DK, Davison DL, Force Aldred FS, Harris HK, Pham PD, Pratap PP, Rangaswamy RU, Schellenberger SU, Shah SN, Trinklein TN, Ugamraj UH, Wiita WA, Van Schooten VW. .
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    92. Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Rep. 2017 Dec 05; 21(10):2678-2687. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA. PMID: 29212016; PMCID: PMC5730067.
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    93. The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma. Mol Cancer Ther. 2017 11; 16(11):2375-2386. Le Moigne R, Aftab BT, Djakovic S, Dhimolea E, Valle E, Murnane M, King EM, Soriano F, Menon MK, Wu ZY, Wong ST, Lee GJ, Yao B, Wiita AP, Lam C, Rice J, Wang J, Chesi M, Bergsagel PL, Kraus M, Driessen C, Kiss von Soly S, Yakes FM, Wustrow D, Shawver L, Zhou HJ, Martin TG, Wolf JL, Mitsiades CS, Anderson DJ, Rolfe M. PMID: 28878026.
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    94. Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics. Cell Syst. 2017 06 28; 4(6):636-644.e9. Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP. PMID: 28578850; PMCID: PMC5546878.
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    95. Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 2017 May 20; 35(15_suppl):8017-8017. Buelow BB, Pham PD, Clarke CS, Force Aldred FS, Dang DK, Pratap PP, Ugamraj UH, Harris HK, Trinklein TN, Schellenberger SU, Wiita WA, Van Schooten VW, Buelow BB. .
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    96. False negative fetal cell free DNA screening for microdeletion syndromes in the presence of an unbalanced translocation involving monosomy 4p. Prenat Diagn. 2017 04; 37(4):420-422. Qi Z, Madaan S, Chetty S, Yu J, Wiita AP. PMID: 28207935.
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    97. Hijacking Myeloma Metabolism to Target Cytotoxic Chemotherapy to Malignant Plasma Cells With Decreased Bone Marrow Toxicity. Clinical Lymphoma Myeloma & Leukemia. 2017 Feb 1; 17(1):e53. Wiita WA, Liu LH, Lam LC, Jandeleit JB, Fischer FW, Koller KK, Hann HB. .
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    98. CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate. Blood. 2016 Dec 2; 128(22):384-384. Sherbenou SD, Aftab AB, Su SY, Behrens BC, Wiita WA, Logan LA, Acosta-Alvear AD, Hann HB, Walter WP, Wu WX, Atkinson AJ, Wolf WJ, Martin MT, Liu LB. .
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    99. Tofacitinib Reverses Growth Promoting Effects of the Bone Marrow Stromal Environment Though Inhibition of JAK1/STAT3 Signaling in Multiple Myeloma. Blood. 2016 Dec 2; 128(22):2098-2098. Lam LC, Murnane MM, Smith SG, Taunton TJ, Aftab AB, Wiita WA. .
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    100. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 12 01; 126(12):4640-4653. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. PMID: 27841764; PMCID: PMC5127683.
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    101. False positive cell free DNA screening for microdeletions due to non-pathogenic copy number variants. Prenat Diagn. 2016 Jun; 36(6):584-6. Mather CA, Qi Z, Wiita AP. PMID: 27061292.
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    102. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. PMID: 27112495; PMCID: PMC4860041.
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    103. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500; PMCID: PMC4833263.
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    104. Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma. Blood. 2015 Dec 3; 126(23):503-503. Murnane MM, Dhimolea DE, Li LR, Bariteau BM, Wheeler WD, Akhurst AR, Logan LA, Munster MP, Wiita WA, Martin MT, Wolf WJ, Liu LJ, Mitsiades MC, Aftab AB. .
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    105. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7594-9. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. PMID: 24821784; PMCID: PMC4040605.
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    106. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. PMID: 24443746; PMCID: PMC3945918.
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    107. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods Enzymol. 2014; 544:327-58. Wiita AP, Seaman JE, Wells JA. PMID: 24974296; PMCID: PMC4260929.
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    108. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104; PMCID: PMC3808542.
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    109. Evaluation of Glutamate Dehydrogenase Immunoassay Screening with Toxin Confirmation for the Diagnosis of Clostridium difficile Infection. Lab Medicine. 2013 Aug 1; 44(3):e65-e71. Miller MS, Wiita WA, Wright WC, Reyes RH, Liu LC. .
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    110. Longitudinal management with crossmatch-compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes (CME). Transfusion. 2012 Oct; 52(10):2146-54. Wiita AP, Nambiar A. PMID: 23113654.
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    111. Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis. Transpl Infect Dis. 2012 Jun; 14(3):248-58. Wiita AP, Roubinian N, Khan Y, Chin-Hong PV, Singer JP, Golden JA, Miller S. PMID: 22385394.
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    112. Clinical application of high throughput molecular screening techniques for pharmacogenomics. Pharmgenomics Pers Med. 2011; 4:109-21. Wiita AP, Schrijver I. PMID: 23226057; PMCID: PMC3513223.
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    113. Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology. 2009 Dec 1; 16(12):1331-1331. Perez-Jimenez PR, Li LJ, Kosuri KP, Sanchez-Romero SI, Wiita WA, Rodriguez-Larrea RD, Chueca CA, Holmgren HA, Miranda-Vizuete MA, Becker BK, Cho CS, Beckwith BJ, Gelhaye GE, Jacquot JJ, Gaucher GE, Sanchez-Ruiz SJ, Berne BB, Fernandez FJ. .
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