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Interstitial macrophages are a focus of viral takeover and inflammation in COVID-19 initiation in human lung. J Exp Med. 2024 Jun 03; 221(6).
Wu TT, Travaglini KJ, Rustagi A, Xu D, Zhang Y, Andronov L, Jang S, Gillich A, Dehghannasiri R, Martínez-Colón GJ, Beck A, Liu DD, Wilk AJ, Morri M, Trope WL, Bierman R, Weissman IL, Shrager JB, Quake SR, Kuo CS, Salzman J, Moerner WE, Kim PS, Blish CA, Krasnow MA. PMID: 38597954.
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An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med. 2024 Mar 13; 16(738):eadi0979.
Westberg M, Su Y, Zou X, Huang P, Rustagi A, Garhyan J, Patel PB, Fernandez D, Wu Y, Hao C, Lo CW, Karim M, Ning L, Beck A, Saenkham-Huntsinger P, Tat V, Drelich A, Peng BH, Einav S, Tseng CK, Blish C, Lin MZ. PMID: 38478629.
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HumansCells
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Vaccine-Boosted CCP Decreases Virus Replication and Hastens Resolution of Infection Despite Transiently Enhancing Disease in SARS-CoV-2-Infected Hamsters. J Infect Dis. 2024 Jan 12.
Carroll TD, Wong T, Morris MK, Di Germanio C, Ma ZM, Stone M, Ball E, Fritts L, Rustagi A, Simmons G, Busch M, Miller CJ. PMID: 38213276.
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Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection. Res Sq. 2023 May 05.
Choi SS, van Unen V, Zhang H, Rustagi A, Alwahabi SA, Santos AJM, Chan JE, Lam B, Solis D, Mah J, Röltgen K, Trope W, Guh-Siesel A, Lin Z, Beck A, Edwards C, Mallajosyula V, Martin BA, Dunn JCY, Shrager J, Baric RA, Pinsky B, Boyd SD, Blish CA, Davis MM, Kuo CJ. PMID: 37205380; PMCID: PMC10187413.
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Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report. Ann N Y Acad Sci. 2023 Mar; 1521(1):32-45.
Cable J, Balachandran S, Daley-Bauer LP, Rustagi A, Antony F, Frere JJ, Strampe J, Kedzierska K, Cannon JL, McGargill MA, Weiskopf D, Mettelman RC, Niessl J, Thomas PG, Briney B, Valkenburg SA, Bloom JD, Bjorkman PJ, Iketani S, Rappazzo CG, Crooks CM, Crofts KF, Pöhlmann S, Krammer F, Sant AJ, Nabel GJ, Schultz-Cherry S. PMID: 36718537.
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SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D. Cell Rep. 2022 Dec 27; 41(13):111892.
Lee MJ, Leong MW, Rustagi A, Beck A, Zeng L, Holmes S, Qi LS, Blish CA. PMID: 36543165; PMCID: PMC9742201.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages. Sci Transl Med. 2022 Dec 07; 14(674):eabm9151.
Martínez-Colón GJ, Ratnasiri K, Chen H, Jiang S, Zanley E, Rustagi A, Verma R, Chen H, Andrews JR, Mertz KD, Tzankov A, Azagury D, Boyd J, Nolan GP, Schürch CM, Matter MS, Blish CA, McLaughlin TL. PMID: 36137009; PMCID: PMC9529056.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Using a 29-mRNA Host Response Classifier To Detect Bacterial Coinfections and Predict Outcomes in COVID-19 Patients Presenting to the Emergency Department. Microbiol Spectr. 2022 Dec 21; 10(6):e0230522.
Ram-Mohan N, Rogers AJ, Blish CA, Nadeau KC, Zudock EJ, Kim D, Quinn JV, Sun L, Liesenfeld O, Stanford COVID-19 Biobank Study Group, Yang S. PMID: 36250865; PMCID: PMC9769905.
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1 Fields:
Translation:
HumansCells
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The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 Oct 07; 378(6615):eabn5648.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. PMID: 36074821; PMCID: PMC9547973.
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16 Fields:
Translation:
HumansAnimalsCells
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Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2. Nat Med. 2022 Sep; 28(9):1944-1955.
Hagey RJ, Elazar M, Pham EA, Tian S, Ben-Avi L, Bernardin-Souibgui C, Yee MF, Moreira FR, Rabinovitch MV, Meganck RM, Fram B, Beck A, Gibson SA, Lam G, Devera J, Kladwang W, Nguyen K, Xiong A, Schaffert S, Avisar T, Liu P, Rustagi A, Fichtenbaum CJ, Pang PS, Khatri P, Tseng CT, Taubenberger JK, Blish CA, Hurst BL, Sheahan TP, Das R, Glenn JS. PMID: 35982307; PMCID: PMC10132811.
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11 Fields:
Translation:
AnimalsCells
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An intranasal ASO therapeutic targeting SARS-CoV-2. Nat Commun. 2022 08 03; 13(1):4503.
Zhu C, Lee JY, Woo JZ, Xu L, Nguyenla X, Yamashiro LH, Ji F, Biering SB, Van Dis E, Gonzalez F, Fox D, Wehri E, Rustagi A, Pinsky BA, Schaletzky J, Blish CA, Chiu C, Harris E, Sadreyev RI, Stanley S, Kauppinen S, Rouskin S, Näär AM. PMID: 35922434; PMCID: PMC9349213.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Nat Genet. 2022 08; 54(8):1078-1089.
Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. PMID: 35879412; PMCID: PMC9355872.
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42 Fields:
Translation:
HumansAnimalsCells
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Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome. JCI Insight. 2022 07 08; 7(13).
Jia X, Cao S, Lee AS, Manohar M, Sindher SB, Ahuja N, Artandi M, Blish CA, Blomkalns AL, Chang I, Collins WJ, Desai M, Din HN, Do E, Fernandes A, Geng LN, Rosenberg-Hasson Y, Mahoney MR, Glascock AL, Chan LY, Fong SY, CLIAHUB Consortium, Chan Zuckerberg Biohub, Phelps M, Raeber O, Stanford COVID-19 Biobank Study Group, Purington N, Röltgen K, Rogers AJ, Snow T, Wang TT, Solis D, Vaughan L, Verghese M, Maecker H, Wittman R, Puri R, Kistler A, Yang S, Boyd SD, Pinsky BA, Chinthrajah S, Nadeau KC. PMID: 35801588; PMCID: PMC9310538.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections. JCI Insight. 2022 06 22; 7(12).
Kratochvil MJ, Kaber G, Demirdjian S, Cai PC, Burgener EB, Nagy N, Barlow GL, Popescu M, Nicolls MR, Ozawa MG, Regula DP, Pacheco-Navarro AE, Yang S, de Jesus Perez VA, Karmouty-Quintana H, Peters AM, Zhao B, Buja ML, Johnson PY, Vernon RB, Wight TN, Stanford COVID-19 Biobank Study Group, Milla CE, Rogers AJ, Spakowitz AJ, Heilshorn SC, Bollyky PL. PMID: 35730564; PMCID: PMC9309048.
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5 Fields:
Translation:
HumansCells
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Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro. Nat Commun. 2022 May 19; 13(1):2766.
Zeng L, Liu Y, Nguyenla XH, Abbott TR, Han M, Zhu Y, Chemparathy A, Lin X, Chen X, Wang H, Rane DA, Spatz JM, Jain S, Rustagi A, Pinsky B, Zepeda AE, Kadina AP, Walker JA, Holden K, Temperton N, Cochran JR, Barron AE, Connolly MD, Blish CA, Lewis DB, Stanley SA, La Russa MF, Qi LS. PMID: 35589813; PMCID: PMC9119983.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Facile discovery of surrogate cytokine agonists. Cell. 2022 Apr 14; 185(8):1414-1430.e19.
Yen M, Ren J, Liu Q, Glassman CR, Sheahan TP, Picton LK, Moreira FR, Rustagi A, Jude KM, Zhao X, Blish CA, Baric RS, Su LL, Garcia KC. PMID: 35325595; PMCID: PMC9021867.
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22 Fields:
Translation:
HumansCells
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The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters. PLoS Pathog. 2022 02; 18(2):e1009914.
Carroll T, Fox D, van Doremalen N, Ball E, Morris MK, Sotomayor-Gonzalez A, Servellita V, Rustagi A, Yinda CK, Fritts L, Port JR, Ma ZM, Holbrook MG, Schulz J, Blish CA, Hanson C, Chiu CY, Munster V, Stanley S, Miller CJ. PMID: 35143587; PMCID: PMC8865701.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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SARS-CoV-2 RNAemia Predicts Clinical Deterioration and Extrapulmonary Complications from COVID-19. Clin Infect Dis. 2022 Jan 29; 74(2):218-226.
Ram-Mohan N, Kim D, Zudock EJ, Hashemi MM, Tjandra KC, Rogers AJ, Blish CA, Nadeau KC, Newberry JA, Quinn JV, O'Hara R, Ashley E, Nguyen H, Jiang L, Hung P, Blomkalns AL, Yang S, Stanford COVID-19 Biobank Study Group. PMID: 33949665; PMCID: PMC8135992.
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34 Fields:
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19. J Exp Med. 2021 Aug 02; 218(8).
Wilk AJ, Lee MJ, Wei B, Parks B, Pi R, Martínez-Colón GJ, Ranganath T, Zhao NQ, Taylor S, Becker W, Stanford COVID-19 Biobank, Jimenez-Morales D, Blomkalns AL, O'Hara R, Ashley EA, Nadeau KC, Yang S, Holmes S, Rabinovitch M, Rogers AJ, Greenleaf WJ, Blish CA. PMID: 34128959; PMCID: PMC8210586.
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92 Fields:
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SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples. Open Forum Infect Dis. 2021 Jul; 8(7):ofab310.
Verma R, Kim E, Martínez-Colón GJ, Jagannathan P, Rustagi A, Parsonnet J, Bonilla H, Khosla C, Holubar M, Subramanian A, Singh U, Maldonado Y, Blish CA, Andrews JR. PMID: 34295944; PMCID: PMC8291522.
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14
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Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19. ACS Cent Sci. 2021 Apr 28; 7(4):650-657.
Delaveris CS, Wilk AJ, Riley NM, Stark JC, Yang SS, Rogers AJ, Ranganath T, Nadeau KC, Stanford COVID-19 Biobank, Blish CA, Bertozzi CR. PMID: 34056095; PMCID: PMC8009098.
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PubMed Mentions:
22
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Occurrence and Timing of Subsequent Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-transcription Polymerase Chain Reaction Positivity Among Initially Negative Patients. Clin Infect Dis. 2021 Jan 27; 72(2):323-326.
Long DR, Gombar S, Hogan CA, Greninger AL, O'Reilly-Shah V, Bryson-Cahn C, Stevens B, Rustagi A, Jerome KR, Kong CS, Zehnder J, Shah NH, Weiss NS, Pinsky BA, Sunshine JE. PMID: 33501950; PMCID: PMC7314163.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome. Sci Immunol. 2020 Dec 07; 5(54).
Röltgen K, Powell AE, Wirz OF, Stevens BA, Hogan CA, Najeeb J, Hunter M, Wang H, Sahoo MK, Huang C, Yamamoto F, Manohar M, Manalac J, Otrelo-Cardoso AR, Pham TD, Rustagi A, Rogers AJ, Shah NH, Blish CA, Cochran JR, Jardetzky TS, Zehnder JL, Wang TT, Narasimhan B, Gombar S, Tibshirani R, Nadeau KC, Kim PS, Pinsky BA, Boyd SD. PMID: 33288645; PMCID: PMC7857392.
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PubMed Mentions:
272 Fields:
Translation:
HumansCells
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Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature. 2020 12; 588(7839):670-675.
Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ. PMID: 33238290; PMCID: PMC8003326.
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PubMed Mentions:
172 Fields:
Translation:
HumansCells
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Profiling of the Human Natural Killer Cell Receptor-Ligand Repertoire. J Vis Exp. 2020 Nov 19; (165).
Vendrame E, McKechnie JL, Ranganath T, Zhao NQ, Rustagi A, Vergara R, Ivison GT, Kronstad LM, Simpson LJ, Blish CA. PMID: 33283785; PMCID: PMC7935321.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis. JCI Insight. 2020 Sep 03; 5(17).
Wilson JG, Simpson LJ, Ferreira AM, Rustagi A, Roque J, Asuni A, Ranganath T, Grant PM, Subramanian A, Rosenberg-Hasson Y, Maecker HT, Holmes SP, Levitt JE, Blish CA, Rogers AJ. PMID: 32706339; PMCID: PMC7526438.
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PubMed Mentions:
146 Fields:
Translation:
HumansPHPublic Health
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Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2. Cell Host Microbe. 2020 Oct 07; 28(4):516-525.e5.
Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Jean GH, Stevens BA, Lee JY, Rustagi A, Rogers AJ, Powell AE, Hunter M, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Nadeau KC, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD. PMID: 32941787; PMCID: PMC7470783.
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PubMed Mentions:
140 Fields:
Translation:
HumansCellsPHPublic Health
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A single-cell atlas of the peripheral immune response in patients with severe COVID-19. Nat Med. 2020 Jul; 26(7):1070-1076.
Wilk AJ, Rustagi A, Zhao NQ, Roque J, Martínez-Colón GJ, McKechnie JL, Ivison GT, Ranganath T, Vergara R, Hollis T, Simpson LJ, Grant P, Subramanian A, Rogers AJ, Blish CA. PMID: 32514174; PMCID: PMC7382903.
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PubMed Mentions:
841 Fields:
Translation:
HumansCellsPHPublic Health
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Eremothecium coryli bloodstream infection in a patient with acute myeloid leukemia: first case report of human infection. Diagn Microbiol Infect Dis. 2019 Sep; 95(1):77-79.
Multani A, Rustagi A, Epstein DJ, Gomez CA, Budvytiene I, Banaei N, Brown JM, Liu AY. PMID: 31005402.
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Translation:
HumansAnimals
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Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):E3071-E3080.
Luo D, de Morree A, Boutet S, Quach N, Natu V, Rustagi A, Rando TA. PMID: 28351977; PMCID: PMC5393251.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Innate antiviral immune signaling, viral evasion and modulation by HIV-1. J Mol Biol. 2014 Mar 20; 426(6):1161-77.
Rustagi A, Gale M. PMID: 24326250; PMCID: PMC7425209.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Two new monoclonal antibodies for biochemical and flow cytometric analyses of human interferon regulatory factor-3 activation, turnover, and depletion. Methods. 2013 Feb; 59(2):225-32.
Rustagi A, Doehle BP, McElrath MJ, Gale M. PMID: 22705311; PMCID: PMC3568209.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism. J Virol. 2012 Aug; 86(16):8367-74.
Doehle BP, Chang K, Rustagi A, McNevin J, McElrath MJ, Gale M. PMID: 22593165; PMCID: PMC3421752.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. Blood. 2011 Jul 14; 118(2):298-308.
Harman AN, Lai J, Turville S, Samarajiwa S, Gray L, Marsden V, Mercier SK, Jones K, Nasr N, Rustagi A, Cumming H, Donaghy H, Mak J, Gale M, Churchill M, Hertzog P, Cunningham AL. PMID: 21411754; PMCID: PMC4123420.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides. Nucleic Acids Res. 2009 Dec; 37(22):7468-82.
Bertoni C, Rustagi A, Rando TA. PMID: 19854937; PMCID: PMC2794159.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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An inwardly rectifying potassium channel in apical membrane of Calu-3 cells. J Biol Chem. 2004 Nov 05; 279(45):46558-65.
Wu JV, Krouse ME, Rustagi A, Joo NS, Wine JJ. PMID: 15328350.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells. J Biol Chem. 2004 Sep 10; 279(37):38854-60.
Joo NS, Lee DJ, Winges KM, Rustagi A, Wine JJ. PMID: 15234967.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells