Arun Padmanabhan, MD, PhD
| Title(s) | Sanchita and Dipten Deb Endowed Professor in Cardiovascular Genetics |
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Biography
| University of California San Francisco | | 2017 | Cardiovascular Disease Fellowship |
| Massachusetts General Hospital, Harvard Medical School | | 2014 | Internal Medicine Residency |
| University of Pennsylvania | M.D. | 2012 | |
| University of Pennsylvania | Ph.D. | 2010 | Cell & Developmental Biology |
| Washington University in St. Louis | A.B. | 2003 | Biochemistry & Molecular Biology |
Overview
CLINICAL INTERESTS: Dr. Padmanabhan is a cardiologist specializing in general cardiology. His specific interests include preventive cardiology, lamin A/C gene (LMNA) associated cardiomyopathies, and right heart disease in athletes.
RESEARCH INTERESTS: Dr. Padmanabhan’s research focuses on understanding the gene-regulatory and epigenetic pathways that govern cell fate decisions during early cardiac development and cell state transitions in the pathophysiology of heart failure.
Bibliographic
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery. bioRxiv. 2025 Jul 26.
Amrute JM, Zhu A, Pai YL, Hector-Greene M, An Y, Kim KR, Sheth MU, Padmanabhan A, Lee CY, Yamawaki T, Sicklinger F, Hartman N, Bredemeyer A, Lee CJM, Xu V, Bell L, Harmon T, Shin H, Parvathaneni A, Liu L, Dutta AK, Pruitt D, Barreda J, Chen J, Shroff UN, Nadadur R, Nigro J, Weinheimer C, Kovacs A, Cui J, Wang C, Li CM, Kreisel D, Liu Y, Foo RS, Schneider RK, Engreitz JM, Mann DL, Rulifson I, Jackson S, Ason B, Kramann R, Drakos SG, Leuschner F, Alexanian M, Lavine KJ. PMID: 40777284; PMCID: PMC12330724.
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Insights Into Recovery From Acute Fulminant Myocarditis Following Successful Treatment With Ruxolitinib by Comprehensive Single-Cell Profiling. Circulation. 2025 Jun 24; 151(25):1814-1817.
Qin J, Aras MA, Song EJ, Connolly AJ, Zhou L, O'Brien C, Salem JE, Padmanabhan A, Moslehi JJ. PMID: 40549846; PMCID: PMC12191800.
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ALPK3 Heterozygous Truncating Variants Cause Late-Onset Hypertrophic Cardiomyopathy With Frequent Apical Involvement and Apical Aneurysm. Circ Genom Precis Med. 2025 Aug; 18(4):e005186.
Busse L, Huth EA, Abraham MR, Abraham T, Padmanabhan A, Wojciak J, Wright G, Aatre R, Campagna R, Jackson E, Kreykes S, Lane K, Sawyer L, Pappas C, Thomas M, VanDyke R, Vedantham V, Higgs EJ. PMID: 40469041.
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Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart. medRxiv. 2024 Nov 22.
Ma XR, Conley SD, Kosicki M, Bredikhin D, Cui R, Tran S, Sheth MU, Qiu WL, Chen S, Kundu S, Kang HY, Amgalan D, Munger CJ, Duan L, Dang K, Rubio OM, Kany S, Zamirpour S, DePaolo J, Padmanabhan A, Birth Defects Research Laboratory, Olgin J, Damrauer S, Andersson R, Gu M, Priest JR, Quertermous T, Qiu X, Rabinovitch M, Visel A, Pennacchio L, Kundaje A, Glass IA, Gifford CA, Pirruccello JP, Goodyer WR, Engreitz JM. PMID: 39606363; PMCID: PMC11601760.
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Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias. JACC Clin Electrophysiol. 2025 Jan; 11(1):143-155.
Caudal A, Liu Y, Pang PD, Maison DP, Nakasuka K, Feng J, Schwarzer-Sperber HS, Schwarzer R, Moffatt E, Henrich TJ, Padmanabhan A, Connolly AJ, Wu JC, Tseng ZH. PMID: 39545913; PMCID: PMC11809765.
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1 Fields:
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HumansCells
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Chromatin remodelling drives immune cell-fibroblast communication in heart failure. Nature. 2024 Nov; 635(8038):434-443.
Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, Gardner Z, Li L, Costa MW, Jain R, Charo I, Combes AJ, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. PMID: 39443808; PMCID: PMC11698514.
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26 Fields:
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HumansAnimalsCells
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Automated Assessment of Right Atrial Pressure From Ultrasound Videos Using Machine Learning. JACC Adv. 2024 Sep; 3(9):101192.
Yurk D, Barrios JP, Labrecque Langlais E, Avram R, Aras MA, Abu-Mostafa Y, Padmanabhan A, Tison GH. PMID: 39372459; PMCID: PMC11450965.
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Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts. bioRxiv. 2024 Apr 24.
Thottakara T, Padmanabhan A, Tanriverdi T, Thambidurai T, Diaz-Rg JA, Amonkar SR, Olgin JE, Long CS, Roselle Abraham M. PMID: 38903075; PMCID: PMC11188105.
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A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nat Cardiovasc Res. 2024 03; 3(3):317-331.
Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU, Jain M, Haldar SM, Srivastava D, Jain R. PMID: 39196112; PMCID: PMC11361716.
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5 Fields:
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HumansAnimalsCells
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Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes. Nat Cardiovasc Res. 2023 Dec; 2(12):1190-1203.
Nishino T, Ranade SS, Pelonero A, van Soldt BJ, Ye L, Alexanian M, Koback F, Huang Y, Sadagopan N, Lam A, Zholudeva LV, Li F, Padmanabhan A, Thomas R, van Bemmel JG, Gifford CA, Costa MW, Srivastava D. PMID: 39183978; PMCID: PMC11343316.
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4 Fields:
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AnimalsCells
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Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture. Bio Protoc. 2023 Jan 20; 13(2).
Chorba JS, Xia VQ, Smith GA, Padmanabhan A. PMID: 36789164; PMCID: PMC9901452.
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Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis. bioRxiv. 2023 Jan 07.
Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. PMID: 36711864; PMCID: PMC9881961.
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Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Sci Transl Med. 2022 09 14; 14(662):eabj8670.
Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. PMID: 36103516; PMCID: PMC10174261.
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9 Fields:
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HumansAnimalsCells
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Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation. 2022 09 06; 146(10):770-787.
Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D. PMID: 35938400; PMCID: PMC9452483.
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14 Fields:
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HumansAnimalsCells
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Targeting transcription in heart failure via CDK7/12/13 inhibition. Nat Commun. 2022 07 27; 13(1):4345.
Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM. PMID: 35896549; PMCID: PMC9329381.
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6 Fields:
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HumansAnimalsCells
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Prospective Comparison of Geriatric Assessment and Provider's Assessment of Older Adults With Metastatic Breast Cancer in the Community. Oncologist. 2022 03 04; 27(2):e133-e141.
Seedor RS, Meeker CR, Lewis B, Handorf EA, Filchner KA, Varadarajan R, Hensold J, Padmanabhan A, Negin B, Blankstein K, Chawla NR, Song WF, Epstein J, Winn J, Goldstein LJ, Dotan E. PMID: 35641214; PMCID: PMC8895742.
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1 Fields:
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HumansPHPublic Health
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Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022 03 03; 185(5):794-814.e30.
Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. PMID: 35182466; PMCID: PMC8923057.
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36 Fields:
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Animals
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Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021 Dec; 53(12):1723.
Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. PMID: 34725478.
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1 Fields:
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BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021 10; 53(10):1480-1492.
Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. PMID: 34611363; PMCID: PMC8500624.
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43 Fields:
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HumansAnimalsCells
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Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell Syst. 2021 09 22; 12(9):885-899.e8.
Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Pérez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A. PMID: 34352221; PMCID: PMC8522198.
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13 Fields:
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HumansCells
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A transcriptional switch governs fibroblast activation in heart disease. Nature. 2021 07; 595(7867):438-443.
Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. PMID: 34163071; PMCID: PMC8341289.
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100 Fields:
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HumansAnimalsCells
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BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation. 2020 12 15; 142(24):2338-2355.
Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. PMID: 33094644; PMCID: PMC7736290.
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32 Fields:
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HumansAnimalsCells
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Drugging transcription in heart failure. J Physiol. 2020 07; 598(14):3005-3014.
Padmanabhan A, Haldar SM. PMID: 30927446.
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5 Fields:
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HumansCells
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Epigenetic therapies in heart failure. J Mol Cell Cardiol. 2019 05; 130:197-204.
Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM. PMID: 30991033; PMCID: PMC6850768.
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14 Fields:
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HumansAnimalsCells
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A Wide Complex Tachycardia in a Woman During Exercise: Did She Tread Into Dangerous Territory? JAMA Intern Med. 2019 Jan 01; 179(1):101-103.
Muniyappa A, Padmanabhan A, Goldschlager N. PMID: 30419135.
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Humans
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Unusual transcription factor protects against heart failure. Science. 2018 12 21; 362(6421):1359-1360.
Padmanabhan A, Haldar SM. PMID: 30573617.
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2 Fields:
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Humans
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Electrical Alternans in Disguise-A Curious Case of Atrial Flutter. JAMA Intern Med. 2018 Dec 01; 178(12):1704-1705.
Cedarbaum ER, Padmanabhan A, Goldschlager N. PMID: 30383080.
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Humans
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Not Your Typical ST-Elevation Myocardial Infarction. JAMA Intern Med. 2018 02 01; 178(2):283-285.
Morehead-Gee A, Padmanabhan A, Goldschlager N. PMID: 29159403.
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Humans
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Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform. Circ Heart Fail. 2018 02; 11(2):e004793.
Padmanabhan A, Haldar SM. PMID: 29438983; PMCID: PMC5813833.
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1 Fields:
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Humans
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Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife. 2015 Oct 13; 4:e07780.
Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA. PMID: 26460546; PMCID: PMC4714971.
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11 Fields:
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Animals
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HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science. 2015 Jun 26; 348(6242):aaa6071.
Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA. PMID: 26113728; PMCID: PMC4806339.
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81 Fields:
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AnimalsCells
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Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun. 2015 Apr 13; 6:6727.
Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BLM, Epstein JA. PMID: 25865356; PMCID: PMC4396689.
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165 Fields:
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HumansAnimalsCells
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Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production. Proc (Bayl Univ Med Cent). 2015 Jan; 28(1):46-9.
Vaduganathan M, Nagarur A, Kerr DA, Lauter KB, Padmanabhan A, Raghavan S, Pallais JC, Fenves AZ. PMID: 25552797; PMCID: PMC4264709.
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Neuroprotection in ischemic stroke: AhR we making progress? Circulation. 2014 Dec 02; 130(23):2002-4.
Padmanabhan A, Haldar SM. PMID: 25359167.
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3 Fields:
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HumansAnimalsCells
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Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development. 2013 Apr; 140(8):1655-64.
Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA. PMID: 23487314; PMCID: PMC3621484.
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47 Fields:
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AnimalsCells
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Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech. 2012 Nov; 5(6):881-94.
Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT. PMID: 22773753; PMCID: PMC3484870.
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60 Fields:
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AnimalsCells
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Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development. 2011 Oct; 138(20):4555-64.
Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA. PMID: 21937602; PMCID: PMC3177320.
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56 Fields:
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AnimalsCells
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Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet. 2010 Dec 01; 19(23):4643-53.
Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT. PMID: 20858602; PMCID: PMC3999377.
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30 Fields:
Translation:
AnimalsCells
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 2010 Aug 26; 466(7310):1069-75.
Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD. PMID: 20740007; PMCID: PMC2965417.
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708 Fields:
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HumansAnimalsCells
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Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging. 2010 May; 3(3):314-22.
Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. PMID: 20190279; PMCID: PMC3059892.
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146 Fields:
Translation:
Animals
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Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15; 339(2):519-27.
Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA. PMID: 20045680; PMCID: PMC2830354.
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36 Fields:
Translation:
AnimalsCells
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Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22305-10.
Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA. PMID: 19966217; PMCID: PMC2799742.
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16 Fields:
Translation:
HumansAnimalsCells
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Investigating magnetically aligned phospholipid bilayers with various lanthanide ions for X-band spin-label EPR studies. Biochim Biophys Acta. 2003 May 02; 1612(1):52-8.
Caporini MA, Padmanabhan A, Cardon TB, Lorigan GA. PMID: 12729929.
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3 Fields:
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Magnetically aligned phospholipid bilayers at the parallel and perpendicular orientations for X-band spin-label EPR studies. J Am Chem Soc. 2001 Mar 28; 123(12):2913-4.
Cardon TB, Tiburu EK, Padmanabhan A, Howard KP, Lorigan GA. PMID: 11456991.
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PubMed Mentions:
10 Fields:
This graph shows the total number of publications by year. To see the data as text,
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| Year | Publications |
|---|
| 2001 | 1 |
| 2003 | 1 |
| 2009 | 1 |
| 2010 | 4 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 4 |
| 2018 | 4 |
| 2019 | 3 |
| 2020 | 1 |
| 2021 | 4 |
| 2022 | 5 |
| 2023 | 3 |
| 2024 | 6 |
| 2025 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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