Michael Alexanian, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street
San Francisco CA 94158
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression. Am J Physiol Heart Circ Physiol. 2025 Feb 01; 328(2):H294-H309. Schuetze KB, Stratton MS, Bagchi RA, Hobby ARH, Felisbino MB, Rubino M, Toni LS, Reges C, Cavasin MA, McMahan RH, Alexanian M, Vagnozzi RJ, McKinsey TA. PMID: 39716819.
      View in: PubMed   Mentions:    Fields:    
    2. Chromatin remodelling drives immune cell-fibroblast communication in heart failure. Nature. 2024 Nov; 635(8038):434-443. Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, Gardner Z, Li L, Costa MW, Jain R, Charo I, Combes AJ, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. PMID: 39443808; PMCID: PMC11698514.
      View in: PubMed   Mentions: 2     Fields:    
    3. A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nat Cardiovasc Res. 2024 03; 3(3):317-331. Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU, Jain M, Haldar SM, Srivastava D, Jain R. PMID: 39196112; PMCID: PMC11361716.
      View in: PubMed   Mentions: 1  Translation:HumansAnimalsCells
    4. Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes. Nat Cardiovasc Res. 2023 Dec; 2(12):1190-1203. Nishino T, Ranade SS, Pelonero A, van Soldt BJ, Ye L, Alexanian M, Koback F, Huang Y, Sadagopan N, Lam A, Zholudeva LV, Li F, Padmanabhan A, Thomas R, van Bemmel JG, Gifford CA, Costa MW, Srivastava D. PMID: 39183978; PMCID: PMC11343316.
      View in: PubMed   Mentions: 1  Translation:AnimalsCells
    5. Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis. bioRxiv. 2023 Jan 07. Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. PMID: 36711864; PMCID: PMC9881961.
      View in: PubMed   Mentions: 1  
    6. Transcriptional plasticity of fibroblasts in heart disease. Biochem Soc Trans. 2022 10 31; 50(5):1247-1255. Micheletti R, Alexanian M. PMID: 36281993; PMCID: PMC9704531.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Targeting transcription in heart failure via CDK7/12/13 inhibition. Nat Commun. 2022 07 27; 13(1):4345. Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM. PMID: 35896549; PMCID: PMC9329381.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. Sci Adv. 2022 Mar 11; 8(10):eabj2917. Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM. PMID: 35263131; PMCID: PMC8906731.
      View in: PubMed   Mentions: 5     Fields:    
    9. Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022 03 03; 185(5):794-814.e30. Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. PMID: 35182466; PMCID: PMC8923057.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    10. Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids. Cell Stem Cell. 2021 12 02; 28(12):2137-2152.e6. Silva AC, Matthys OB, Joy DA, Kauss MA, Natarajan V, Lai MH, Turaga D, Blair AP, Alexanian M, Bruneau BG, McDevitt TC. PMID: 34861147.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    11. A transcriptional switch governs fibroblast activation in heart disease. Nature. 2021 07; 595(7867):438-443. Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. PMID: 34163071; PMCID: PMC8341289.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    12. Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Syst. 2020 12 16; 11(6):625-639.e13. Shim WJ, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, Shen S, Sun Y, Balderson B, Boix C, Peng G, Jing N, Wang Y, Kellis M, Tam PPL, Smith A, Piper M, Christiaen L, Nguyen Q, Bodén M, Palpant NJ. PMID: 33278344; PMCID: PMC7781436.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    13. Long Noncoding RNAs in Cardiac Development. Cold Spring Harb Perspect Biol. 2020 11 02; 12(11). Alexanian M, Ounzain S. PMID: 31932317; PMCID: PMC7605224.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    14. BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation. 2020 12 15; 142(24):2338-2355. Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. PMID: 33094644; PMCID: PMC7736290.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    15. BETs that cover the spread from acquired to heritable heart failure. J Clin Invest. 2020 09 01; 130(9):4536-4539. Alexanian M, Haldar SM. PMID: 32773407; PMCID: PMC7456232.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    16. Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Circ Res. 2019 09 13; 125(7):662-677. Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. PMID: 31409188; PMCID: PMC7310347.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    17. Epigenetic therapies in heart failure. J Mol Cell Cardiol. 2019 05; 130:197-204. Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM. PMID: 30991033; PMCID: PMC6850768.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. The Cardiac Myofibroblast. Circ Res. 2018 12 07; 123(12):1258-1260. Alexanian M, Haldar SM. PMID: 30566054; PMCID: PMC6453134.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. A transcribed enhancer dictates mesendoderm specification in pluripotency. Nat Commun. 2017 11 27; 8(1):1806. Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T. PMID: 29180618; PMCID: PMC5703900.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    20. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Sci Transl Med. 2017 06 21; 9(395). Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, González A, Ounzain S, Pedrazzini T. PMID: 28637928; PMCID: PMC5643582.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansCells
    21. New Lncs to mesendoderm specification. J Thorac Dis. 2017 Mar; 9(Suppl 1):S5-S8. Alexanian M, Pedrazzini T, Ounzain S. PMID: 28446963; PMCID: PMC5383557.
      View in: PubMed   Mentions: 1  
    22. CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. J Mol Cell Cardiol. 2015 Dec; 89(Pt A):98-112. Ounzain S, Micheletti R, Arnan C, Plaisance I, Cecchi D, Schroen B, Reverter F, Alexanian M, Gonzales C, Ng SY, Bussotti G, Pezzuto I, Notredame C, Heymans S, Guigó R, Johnson R, Pedrazzini T. PMID: 26423156.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    23. Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease. J Mol Cell Cardiol. 2014 Nov; 76:55-70. Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M, Gonzales C, Sarre A, Alexanian M, Blow MJ, May D, Johnson R, Dauvillier J, Pennacchio LA, Pedrazzini T. PMID: 25149110; PMCID: PMC4445080.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    24. Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs. Eur Heart J. 2015 Feb 07; 36(6):353-68a. Ounzain S, Micheletti R, Beckmann T, Schroen B, Alexanian M, Pezzuto I, Crippa S, Nemir M, Sarre A, Johnson R, Dauvillier J, Burdet F, Ibberson M, Guigó R, Xenarios I, Heymans S, Pedrazzini T. PMID: 24786300; PMCID: PMC4320320.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
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