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John Chorba, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.2007
    Massachusetts General HospitalInternal Medicine Residency2010
    University of California, San FranciscoCardiology Fellowship2014
    Collapse Awards and Honors
    American Heart Association2011Laennec Young Clinician Award
    NIH/NHLBI2012  - 2014Ruth L. Kirschstein F32 National Research Service Award
    NIH/NHLBI2013  - 2017Loan Repayment Program
    Gilead Sciences2013  - 2016Research Scholar in Cardiovascular Disease Award
    NIH/NHLBI2015  - 2020K08 Mentored Clinical Scientist Development Award
    UCSF CTSI2015  - 2016Catalyst Award
    UCSF Academic Senate2015  - 2017Pilot Investigator Award
    Hellman Fellows Fund2015  - 2017Hellman Fellowship
    Pfizer2015  - 2018ASPIRE Cardiovascular Award

    Collapse Overview 
    Collapse Overview
    My interests lie in using chemical tools to probe biological mechanisms of disease, with the ultimate goal of developing a better understanding of heart disease to develop novel therapeutics. Currently, my work focuses on the processing mechanisms of PCSK9, a protein that causes elevated cholesterol levels, so as to develop new drug targets against atherosclerosis.

    Collapse Research 
    Collapse Research Activities and Funding
    Mediators of PCSK9 Secretion as Targets Against Atherosclerosis
    NIH/NHLBI R03HL145259Sep 15, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Deep Learning for Automated Aortic Stenosis and Valvular Heart Disease Detection Using a Digital Stethoscope
    NIH/NHLBI R43HL144297Jul 1, 2018 - Dec 31, 2018
    Role: Co-Principal Investigator
    Probing the multiple roles of the PCSK9 active site using chemical biology
    NIH/NHLBI K08HL124068Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Targeting the serine protease PCSK9 via covalent complementarity
    NIH/NHLBI F32HL116189Aug 9, 2012 - Aug 8, 2015
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Student Projects
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Apr 30. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 27     Fields:    
    2. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329.
      View in: PubMed   Mentions:
    3. Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake. J Lipid Res. 2019 01; 60(1):71-84. Galvan AM, Chorba JS. PMID: 30463987.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. J Vis Exp. 2018 08 28; (138). Chorba JS, Galvan AM, Shokat KM. PMID: 30222160.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 05 04; 293(18):6692. Chorba JS, Galvan AM, Shokat KM. PMID: 29728531.
      View in: PubMed   Mentions:    Fields:    
    6. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 02 09; 293(6):1875-1886. Chorba JS, Galvan AM, Shokat KM. PMID: 29259136.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service. Am J Med. 2017 Jan; 130(1):47-53. Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. PMID: 27619354.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43. Chorba JS, Shokat KM. PMID: 25210046.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    9. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb; 43(2):441-5. Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. PMID: 22116811.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    10. Sustained ventricular fibrillation in a conscious patient. Arch Intern Med. 2011 Jun 13; 171(11):973, 974-5. Dewland TA, Chorba JS, Goldschlager N, Marcus GM. PMID: 21670368.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15. Li J, Chorba JS, Whelan SP. PMID: 17301155.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):543-6. Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. PMID: 12565968.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):547-51. Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. PMID: 12565969.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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