John Chorba, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
ORCID ORCID Icon0000-0002-6397-6348 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.2007
    Massachusetts General HospitalInternal Medicine Residency2010
    University of California, San FranciscoCardiology Fellowship2014
    University of California, San Francisco2022Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    American Heart Association2011Laennec Young Clinician Award
    NIH/NHLBI2012  - 2014Ruth L. Kirschstein F32 National Research Service Award
    NIH/NHLBI2013  - 2017Loan Repayment Program
    Gilead Sciences2013  - 2016Research Scholar in Cardiovascular Disease Award
    NIH/NHLBI2015  - 2020K08 Mentored Clinical Scientist Development Award
    UCSF CTSI2015  - 2016Catalyst Award
    UCSF Academic Senate2015  - 2017Pilot Investigator Award
    Hellman Fellows Fund2015  - 2017Hellman Fellowship
    Pfizer2015  - 2018ASPIRE Cardiovascular Award
    Northwestern Young Cardiovascular Investigators Forum2019Jeremiah Stamler Distinguished Young Investigator Research Award
    American Society for Clinical Investigation2020Young Physician Scientist Award
    Harrington Discovery Institute2021Harrington Scholar Innovator Award

    Collapse Overview 
    Collapse Overview
    My interests lie in using chemical tools to probe biological mechanisms of disease, with the ultimate goal of developing a better understanding of heart disease to develop novel therapeutics. Currently, my work focuses on the processing mechanisms of PCSK9, a protein that causes elevated cholesterol levels, so as to develop new drug targets against atherosclerosis.

    Collapse Research 
    Collapse Research Activities and Funding
    CSDE1 as a Post Transcriptional Regulator of the LDLR
    NIH R01HL159457Jul 15, 2021 - Jun 30, 2025
    Role: Principal Investigator
    Chemical Biology to Modulate PCSK9 and Treat Atherosclerosis
    NIH R01HL146404Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Sequence Specific Inhibition of Protein Translation
    NIH R21GM141609Apr 1, 2021 - Mar 31, 2023
    Role: Principal Investigator
    Mediators of PCSK9 Secretion as Targets Against Atherosclerosis
    NIH R03HL145259Sep 15, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Deep Learning for Automated Aortic Stenosis and Valvular Heart Disease Detection Using a Digital Stethoscope
    NIH R43HL144297Jul 1, 2018 - Dec 31, 2019
    Role: Co-Principal Investigator
    Probing the multiple roles of the PCSK9 active site using chemical biology
    NIH K08HL124068Jul 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Targeting the serine protease PCSK9 via covalent complementarity
    NIH F32HL116189Aug 9, 2012 - Aug 8, 2015
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Collaboration Interests
    Collapse Student Projects

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture. Bio Protoc. 2023 Jan 20; 13(2). Chorba JS, Xia VQ, Smith GA, Padmanabhan A. PMID: 36789164; PMCID: PMC9901452.
      View in: PubMed   Mentions:
    2. Heparin Does Not Regulate Circulating Human PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) in a General Population-Brief Report. Arterioscler Thromb Vasc Biol. 2023 02; 43(2):352-358. Xia VQ, Ong CM, Zier LS, MacGregor JS, Wu AHB, Chorba JS. PMID: 36475702.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Sci Transl Med. 2022 09 14; 14(662):eabj8670. Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. PMID: 36103516.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Physical Maneuvers and Recent Tools to Break the Silence of Clinically Undetectable Heart Sounds. JAMA Intern Med. 2022 05 01; 182(5):574-575. Maidens J, Chorba JS, Thomas JD. PMID: 35377403.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Deep Learning Algorithm for Automated Cardiac Murmur Detection via a Digital Stethoscope Platform. J Am Heart Assoc. 2021 05 04; 10(9):e019905. Chorba JS, Shapiro AM, Le L, Maidens J, Prince J, Pham S, Kanzawa MM, Barbosa DN, Currie C, Brooks C, White BE, Huskin A, Paek J, Geocaris J, Elnathan D, Ronquillo R, Kim R, Alam ZH, Mahadevan VS, Fuller SG, Stalker GW, Bravo SA, Jean D, Lee JJ, Gjergjindreaj M, Mihos CG, Forman ST, Venkatraman S, McCarthy PM, Thomas JD. PMID: 33899504; PMCID: PMC8200722.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    6. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, H?ttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, Garc?a-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 1955     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    7. Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake. J Lipid Res. 2019 01; 60(1):71-84. Galvan AM, Chorba JS. PMID: 30463987; PMCID: PMC6314249.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. J Vis Exp. 2018 08 28; (138). Chorba JS, Galvan AM, Shokat KM. PMID: 30222160; PMCID: PMC6231911.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 05 04; 293(18):6692. Chorba JS, Galvan AM, Shokat KM. PMID: 29728531; PMCID: PMC5936806.
      View in: PubMed   Mentions:    Fields:    
    10. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 02 09; 293(6):1875-1886. Chorba JS, Galvan AM, Shokat KM. PMID: 29259136; PMCID: PMC5808750.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service. Am J Med. 2017 Jan; 130(1):47-53. Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. PMID: 27619354; PMCID: PMC6598201.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43. Chorba JS, Shokat KM. PMID: 25210046; PMCID: PMC4200258.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    13. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb; 43(2):441-5. Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. PMID: 22116811; PMCID: PMC3265658.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    14. Sustained ventricular fibrillation in a conscious patient. Arch Intern Med. 2011 Jun 13; 171(11):973, 974-5. Dewland TA, Chorba JS, Goldschlager N, Marcus GM. PMID: 21670368.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15. Li J, Chorba JS, Whelan SP. PMID: 17301155; PMCID: PMC1866143.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):543-6. Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. PMID: 12565968.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):547-51. Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. PMID: 12565969.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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