John Chorba, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.2007
    Massachusetts General HospitalInternal Medicine Residency2010
    University of California, San FranciscoCardiology Fellowship2014
    Collapse Awards and Honors
    American Heart Association2011Laennec Young Clinician Award
    NIH/NHLBI2012  - 2014Ruth L. Kirschstein F32 National Research Service Award
    NIH/NHLBI2013  - 2017Loan Repayment Program
    Gilead Sciences2013  - 2016Research Scholar in Cardiovascular Disease Award
    NIH/NHLBI2015  - 2020K08 Mentored Clinical Scientist Development Award
    UCSF CTSI2015  - 2016Catalyst Award
    UCSF Academic Senate2015  - 2017Pilot Investigator Award
    Hellman Fellows Fund2015  - 2017Hellman Fellowship
    Pfizer2015  - 2018ASPIRE Cardiovascular Award

    Collapse Overview 
    Collapse Overview
    My interests lie in using chemical tools to probe biological mechanisms of disease, with the ultimate goal of developing a better understanding of heart disease to develop novel therapeutics. Currently, my work focuses on the processing mechanisms of PCSK9, a protein that causes elevated cholesterol levels, so as to develop new drug targets against atherosclerosis.

    Collapse Research 
    Collapse Research Activities and Funding
    Mediators of PCSK9 Secretion as Targets Against Atherosclerosis
    NIH/NHLBI R03HL145259Sep 15, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Deep Learning for Automated Aortic Stenosis and Valvular Heart Disease Detection Using a Digital Stethoscope
    NIH/NHLBI R43HL144297Jul 1, 2018 - Dec 31, 2018
    Role: Co-Principal Investigator
    Probing the multiple roles of the PCSK9 active site using chemical biology
    NIH/NHLBI K08HL124068Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Targeting the serine protease PCSK9 via covalent complementarity
    NIH/NHLBI F32HL116189Aug 9, 2012 - Aug 8, 2015
    Role: Co-Principal Investigator

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    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Galvan AM, Chorba JS. Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake. J Lipid Res. 2019 01; 60(1):71-84. PMID: 30463987.
      View in: PubMed
    2. Chorba JS, Galvan AM, Shokat KM. A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. J Vis Exp. 2018 08 28; (138). PMID: 30222160.
      View in: PubMed
    3. Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 05 04; 293(18):6692. PMID: 29728531.
      View in: PubMed
    4. Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 02 09; 293(6):1875-1886. PMID: 29259136.
      View in: PubMed
    5. Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service. Am J Med. 2017 Jan; 130(1):47-53. PMID: 27619354.
      View in: PubMed
    6. Chorba JS, Shokat KM. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 17; 289(42):29030-43. PMID: 25210046.
      View in: PubMed
    7. Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb; 43(2):441-5. PMID: 22116811.
      View in: PubMed
    8. Dewland TA, Chorba JS, Goldschlager N, Marcus GM. Sustained ventricular fibrillation in a conscious patient. Arch Intern Med. 2011 Jun 13; 171(11):973, 974-5. PMID: 21670368.
      View in: PubMed
    9. Li J, Chorba JS, Whelan SP. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr; 81(8):4104-15. PMID: 17301155.
      View in: PubMed
    10. Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):547-51. PMID: 12565969.
      View in: PubMed
    11. Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10; 13(3):543-6. PMID: 12565968.
      View in: PubMed