Brian Graham, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone--
ORCID ORCID Icon0000-0001-7541-2585 Additional info
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    Collapse Biography 
    Collapse Education and Training
    MITSB06/2000Electrical Engineering
    MITMEng06/2000Electrical Engineering
    HarvardMD06/2004Medicine
    University of Colorado06/2007Internal Medicine Residency
    University of Colorado06/2010Pulmonary-Critical Care Fellowship
    University of California, San Francisco, CA2021Diversity, Equity and Inclusion Training
    Collapse Awards and Honors
    Parker B Francis Foundation2016Jo Rae Wright Award for Scientific Excellence
    UCSF2020John F. Murray, MD Distinguished Professorship in Pulmonary Medicine

    Collapse Overview 
    Collapse Overview
    I am the Division Chief of Pulmonary and Critical Care Medicine at Zuckerberg San Francisco General Hospital, and a Professor in Residence at UCSF. My primary clinical and research interest is in pulmonary hypertension. I particularly study schistosomiasis associated pulmonary hypertension, a common cause worldwide.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    Complement Mediated Remodeling in Pulmonary Vascular Disease
    NIH P01HL152961Aug 1, 2020 - Jun 30, 2025
    Role: Project 2 Leader
    Description: To study the role of complement in pulmonary hypertension. The focus of Project 2 is on complement in schistosomiasis-associated pulmonary hypertension.
    Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension
    NIH R01HL135872Dec 15, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Role of Th2 CD4 T Cells in Schistosoma Pulmonary Hypertension
    NIH R03HL133306Aug 15, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Schistosomiasis Associated Pulmonary Arterial Hypertension
    NIH K08HL105536Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests
    Collapse Faculty Mentoring
    Collapse Academic Senate
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells. Am J Respir Cell Mol Biol. 2023 May 18. Lee JY, Stevens RP, Pastukh VV, Pastukh VM, Kozhukhar N, Alexeyev MF, Reisz JA, Nerguizian D, D'Alessandro A, Koloteva A, Gwin MS, Roberts JT, Borchert GM, Wagener BM, Pittet JF, Graham BB, Stenmark KR, Stevens T. PMID: 37201952.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension. Clin Sci (Lond). 2023 04 26; 137(8):617-631. Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB. PMID: 37014925; PMCID: PMC10133871.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H804-H820. Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. PMID: 36961489; PMCID: PMC10190846.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities. PLoS Pathog. 2023 01; 19(1):e1011063. Kumar R, Aktay-Cetin Ö, Craddock V, Morales-Cano D, Kosanovic D, Cogolludo A, Perez-Vizcaino F, Avdeev S, Kumar A, Ram AK, Agarwal S, Chakraborty A, Savai R, de Jesus Perez V, Graham BB, Butrous G, Dhillon NK. PMID: 36634048; PMCID: PMC9836319.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned. Eur Respir J. 2022 10; 60(4). Mickael C, Lee MH, Graham BB. PMID: 36202406; PMCID: PMC9924355.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology. Front Physiol. 2022; 13:963881. Lee MH, Menezes TCF, Reisz JA, Ferreira EVM, Graham BB, Oliveira RKF. PMID: 36171971; PMCID: PMC9510894.
      View in: PubMed   Mentions:
    7. HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape. Cells. 2022 08 04; 11(15). Medrano-Garcia S, Morales-Cano D, Barreira B, Vera-Zambrano A, Kumar R, Kosanovic D, Schermuly RT, Graham BB, Perez-Vizcaino F, Mathie A, Savai R, Pullamseti S, Butrous G, Fernández-Malavé E, Cogolludo A. PMID: 35954255; PMCID: PMC9368261.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension. Pulm Circ. 2022 Jul; 12(3):e12105. Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB. PMID: 35874852; PMCID: PMC9297026.
      View in: PubMed   Mentions: 1  
    9. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L355-L371. Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM. PMID: 35763400; PMCID: PMC9448289.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L58-L68. Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. PMID: 35608266; PMCID: PMC9273277.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure. Front Pharmacol. 2022; 13:873867. Chanana N, Palmo T, Sharma K, Kumar R, Shah B, Mahajan S, Palleda GM, Gupta MD, Kukreti R, Faruq M, Thinlas T, Graham BB, Pasha Q. PMID: 35668947; PMCID: PMC9163683.
      View in: PubMed   Mentions:
    12. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2022 05 16; 132(10). Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. PMID: 35575096; PMCID: PMC9106337.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. Am J Respir Cell Mol Biol. 2022 05; 66(5):580-581. Mickael C, Kheyfets VO, Langouët-Astrié C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. PMID: 35486078; PMCID: PMC9116364.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia. Pulm Circ. 2022 Apr; 12(2):e12072. Sinkala E, Ahmed HY, Sibomana JP, Lee MH, Kassa B, Kumar R, Mazimba S, Binegdie AB, Mpisa S, Wamundila K, Graham BB, Hilton JF. PMID: 35514775; PMCID: PMC9063961.
      View in: PubMed   Mentions: 1  
    15. Experimental Schistosoma japonicum-induced pulmonary hypertension. PLoS Negl Trop Dis. 2022 04; 16(4):e0010343. Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB. PMID: 35417453; PMCID: PMC9037943.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. Double Trouble: Airflow and Pulmonary Vascular Obstruction. Am J Respir Crit Care Med. 2021 12 15; 204(12):1365-1367. Lee MH, Graham BB, Bull TM. PMID: 34644521; PMCID: PMC8865726.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling. Am J Respir Cell Mol Biol. 2021 09; 65(3):233-235. Lee MH, Mickael C, Graham BB. PMID: 34029508; PMCID: PMC8485994.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 10 01; 321(4):L675-L685. Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. PMID: 34346780; PMCID: PMC8560395.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension. Eur Respir J. 2021 05; 57(5). Rahaghi FN, Hilton JF, Corrêa RA, Loureiro C, Ota-Arakaki JS, Verrastro CGY, Lee MH, Mickael C, Nardelli P, Systrom DA, Waxman AB, Washko GR, San José Estépar R, Graham BB, Oliveira RKF. PMID: 33446601; PMCID: PMC8106660.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension. Cell Mol Immunol. 2021 02; 18(2):374-384. Florentin J, Zhao J, Tai YY, Vasamsetti SB, O'Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P. PMID: 33420357; PMCID: PMC8027442.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    21. Schistosomiasis Pulmonary Arterial Hypertension. Front Immunol. 2020; 11:608883. Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, Silva LCS, Sinkala E, Ahmed HY, Graham BB. PMID: 33362796; PMCID: PMC7758287.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    22. Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19. ERJ Open Res. 2020 Oct; 6(4). Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B. PMID: 33313306; PMCID: PMC7720688.
      View in: PubMed   Mentions: 5  
    23. Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension. Cardiovasc Res. 2020 10 01; 116(12):2021-2030. Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. PMID: 31710666; PMCID: PMC7519884.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine. Am J Respir Cell Mol Biol. 2020 09; 63(3):279-292. George MP, Gladwin MT, Graham BB. PMID: 32453969; PMCID: PMC7462335.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Sex-derived attributes contributing to SARS-CoV-2 mortality. Am J Physiol Endocrinol Metab. 2020 09 01; 319(3):E562-E567. Chanana N, Palmo T, Sharma K, Kumar R, Graham BB, Pasha Q. PMID: 32726128; PMCID: PMC7473885.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCellsPHPublic Health
    26. Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Sci Rep. 2020 Mar 04; 10(1):4349. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB. PMID: 32132567; PMCID: PMC7055208.
      View in: PubMed   Mentions: 2     Fields:    
    27. Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Sci Rep. 2020 01 15; 10(1):413. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB. PMID: 31942023; PMCID: PMC6962446.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    28. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 12; 54(6). Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. PMID: 31515405; PMCID: PMC6911916.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    29. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension. J Am Heart Assoc. 2019 08 06; 8(15):e013111. Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB. PMID: 31339057; PMCID: PMC6761627.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    30. A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil. Int J Cardiol Heart Vasc. 2019 Sep; 24:100387. Botoni FA, Marinho CC, Carvalho VT, Mickael CS, Graham BB. PMID: 31334331; PMCID: PMC6614534.
      View in: PubMed   Mentions:
    31. IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 07; 61(1):123-126. Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB. PMID: 31259624; PMCID: PMC6604223.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    32. Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. Am J Respir Cell Mol Biol. 2019 06; 60(6):637-649. Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW. PMID: 30562042; PMCID: PMC6543748.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    33. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2019 05 07; 139(19):2238-2255. Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY. PMID: 30759996; PMCID: PMC6519484.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    34. Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective. Cardiovasc Res. 2019 03 15; 115(4):699-700. Mickael C, Lee MH, Gu S, Graham BB. PMID: 30517607; PMCID: PMC6657381.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    35. The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension. Front Immunol. 2019; 10:27. Mickael CS, Graham BB. PMID: 30733718; PMCID: PMC6353826.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    36. Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019 01 01; 199(1):9-11. Graham BB, Yu PB. PMID: 30130137.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Common genetic variants in pulmonary arterial hypertension. Lancet Respir Med. 2019 03; 7(3):190-191. Gu S, Kumar R, Lee MH, Mickael C, Graham BB. PMID: 30527955; PMCID: PMC6768546.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    38. Paclitaxel blocks Th2-mediated TGF-β activation in Schistosoma mansoni-induced pulmonary hypertension. Pulm Circ. 2019 Jan-Mar; 9(1):2045894018820813. Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB. PMID: 30511588; PMCID: PMC6304706.
      View in: PubMed   Mentions: 4  
    39. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 10; 59(4):479-489. Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM. PMID: 29851508; PMCID: PMC6178158.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    40. Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy? Cardiovasc Res. 2018 07 01; 114(8):1057-1059. Stenmark KR, Graham BB. PMID: 29800416; PMCID: PMC6279057.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445). Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. PMID: 29899023; PMCID: PMC6223025.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    42. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Circ Res. 2018 06 08; 122(12):1689-1702. Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR. PMID: 29545367; PMCID: PMC5993601.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    43. Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension. Cardiovasc Res. 2018 03 15; 114(4):551-564. Stenmark KR, Frid MG, Graham BB, Tuder RM. PMID: 29385432; PMCID: PMC5852549.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    44. Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology. Am J Respir Crit Care Med. 2017 10 15; 196(8):1075-1077. Graham BB, Koyanagi D, Kandasamy B, Tuder RM. PMID: 28278380; PMCID: PMC5649987.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    45. TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 05 30; 8:15494. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. PMID: 28555642; PMCID: PMC5459967.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    46. A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. J Immunol. 2017 06 15; 198(12):4802-4812. Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR. PMID: 28500078; PMCID: PMC5501258.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    47. Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling. Pulm Circ. 2017 Mar; 7(1):244-252. Ali Z, Kosanovic D, Kolosionek E, Schermuly RT, Graham BB, Mathie A, Butrous G. PMID: 28680583; PMCID: PMC5448541.
      View in: PubMed   Mentions: 2  
    48. Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle. Am J Respir Crit Care Med. 2016 09 15; 194(6):655-6. Graham BB, Robinson JC, Tuder RM. PMID: 27628075; PMCID: PMC5027232.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016 07 01; 126(7):2465-81. Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC. PMID: 27214549; PMCID: PMC4922712.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    50. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. PMID: 26565914; PMCID: PMC4644508.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    51. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. PMID: 26192556; PMCID: PMC4642207.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    52. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L435-40. Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. PMID: 26115672; PMCID: PMC4556932.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    53. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. PMID: 25825391; PMCID: PMC4459813.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    54. The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):721-9. Robinson JC, Graham BB, Rouault TC, Tuder RM. PMID: 24988529; PMCID: PMC4291546.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    55. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Pulm Circ. 2014 Sep; 4(3):353-62. Graham BB, Kumar R. PMID: 25621148; PMCID: PMC4278594.
      View in: PubMed   Mentions: 14  
    56. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep; 184(9):2382-9. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. PMID: 25016184; PMCID: PMC4188171.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    57. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 08; 124(8):3514-28. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. PMID: 24960162; PMCID: PMC4109523.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    58. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15; 193(2):597-609. El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. PMID: 24928992; PMCID: PMC4100597.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    59. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014 Jun; 4(2):289-99. Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB. PMID: 25006448; PMCID: PMC4070790.
      View in: PubMed   Mentions: 4  
    60. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 May 01; 189(9):1110-20. Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW. PMID: 24605778; PMCID: PMC4098107.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    61. Fat and cardiotoxicity in hereditary pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):247-9. Tuder RM, Robinson JC, Graham BB. PMID: 24484329; PMCID: PMC3977738.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    62. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):951-9. Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. PMID: 23815102; PMCID: PMC3931110.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    63. Updated approach for the assessment of ventilator-associated pneumonia. Crit Care Med. 2013 Nov; 41(11):2641-2. Macht M, Robinson JC, Graham BB. PMID: 24162675; PMCID: PMC3828199.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    64. Pathology of pulmonary hypertension. Clin Chest Med. 2013 Dec; 34(4):639-50. Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB. PMID: 24267295.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    65. Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L725-36. Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez M, Smith L, Graham BB, Kuebler WM, Tuder RM. PMID: 24039255; PMCID: PMC3840271.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    66. Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation. 2013 Sep 17; 128(12):1354-64. Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, Tuder RM. PMID: 23958565; PMCID: PMC3880024.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    67. Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study. Pulm Circ. 2013 Apr; 3(2):356-62. Kolosionek E, King J, Rollinson D, Schermuly RT, Grimminger F, Graham BB, Morrell N, Butrous G. PMID: 24015336; PMCID: PMC3757830.
      View in: PubMed   Mentions: 15  
    68. A sinus venosus atrial septal defect is diagnosed by echocardiography with an unusual bubble study. Echocardiography. 2013 Jul; 30(6):E182-3. Dorosz JL, Fonseca BM, Kay JD, Graham BB, Salcedo EE, Quaife RA. PMID: 23551148; PMCID: PMC9429751.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α. Cell Metab. 2013 Feb 05; 17(2):271-81. Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA. PMID: 23395173; PMCID: PMC3569856.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    70. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc. 2013 Feb; 10(1):1-9. Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC. PMID: 23509326; PMCID: PMC3960991.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    71. Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Aug 01; 186(3):261-72. Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM. PMID: 22679007; PMCID: PMC3886716.
      View in: PubMed   Mentions: 256     Fields:    Translation:Humans
    72. Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension. Am J Respir Crit Care Med. 2012 Feb 01; 185(3):260-6. Tuder RM, Davis LA, Graham BB. PMID: 22077069; PMCID: PMC3297113.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    73. Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension. Pulm Circ. 2011 Oct-Dec; 1(4):456-61. Graham BB, Chabon J, Bandeira A, Espinheira L, Butrous G, Tuder RM. PMID: 22530100; PMCID: PMC3329075.
      View in: PubMed   Mentions: 16  
    74. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol. 2010 Sep; 177(3):1549-61. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. PMID: 20671265; PMCID: PMC2928984.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    75. Tracheal Basal cells: a facultative progenitor cell pool. Am J Pathol. 2010 Jul; 177(1):362-76. Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD. PMID: 20522644; PMCID: PMC2893679.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    76. Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl):20S-29S. Graham BB, Bandeira AP, Morrell NW, Butrous G, Tuder RM. PMID: 20522577; PMCID: PMC5989787.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    77. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med. 2010 Jan; 38(1):16-24. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. PMID: 19789450.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    78. [Pathogenesis of pulmonary hypertension]. Zhonghua Yi Xue Za Zhi. 2009 Aug 11; 89(30):2091-3. Graham BB, Tuder RM. PMID: 20058607.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    79. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L586-95. Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. PMID: 19648283; PMCID: PMC2770785.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    80. Clinical problem-solving. Kiss of death. N Engl J Med. 2009 Jun 11; 360(24):2564-8. Graham BB, Kaul DR, Saint S, Janssen WJ. PMID: 19516037.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    81. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov; 134(5):1074-1079. Graham BB, Burnham EL, Janssen JS, Janssen WJ. PMID: 18988783.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    82. Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):1-6. Tuder RM, Yun JH, Graham BB. PMID: 18441278; PMCID: PMC2720121.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    83. Primary pulmonary lymphoma. Ann Thorac Surg. 2005 Oct; 80(4):1248-53. Graham BB, Mathisen DJ, Mark EJ, Takvorian RW. PMID: 16181848.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    84. End-to-side venous anastomosis with the internal jugular vein stump: a preliminary report. Head Neck. 2004 Jun; 26(6):537-40. Graham BB, Varvares MA. PMID: 15162355.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    85. Pediatric tracheal surgery. Ann Thorac Surg. 2002 Aug; 74(2):308-13; discussion 314. Wright CD, Graham BB, Grillo HC, Wain JC, Mathisen DJ. PMID: 12173805.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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