Jeff Fineman, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street
San Francisco CA 94158
Phone--
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    Collapse Biography 
    Collapse Education and Training
    New York University School of Medicine, New York, NYMD06/1984Medicine
    NYU/Bellevue, New York, NY06/1987Pediatric Residency
    NYU/Bellevue, New York, NY06/1988Pediatric Chief Resident
    UCSF, San Francisco, CA06/1990Pediatric Critical Care Fellowship
    UCSF, San Francisco, CA2021Diversity, Equity, Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield
    Dept. of the Army - USAMRAA 12865254-DM190076Sep 30, 2020 - Sep 29, 2023
    Role: Co-I
    Role Description: We propose that OMX-CV represent a unique class of precision oxygen delivery biotherapeutics with the potential to dramatically decrease reliance on conventional blood products during the treatment of hemorrhagic shock in the battlefield setting.
    Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease
    NIH/NHLBI (University of Arizona) 1P01HL146369-01A1Aug 10, 2020 - Jul 31, 2025
    Role: Co-investigator – Core C Director and Project 1 Leader
    Role Description: As part of this program project, Dr. Fineman will create animal models of Congenital Heart Disease, perform whole animal experiments to complement the cellular and molecular studies of the program project, and generate primary cell culture lines derived from the animal models.
    Large Mammal Neuroprotective Clinical Platform
    Bill and Melinda Gates Foundation OPP1196539Aug 1, 2018 - Jul 31, 2022
    Role: Co-Investigator
    Role Description: The major goals of this project are to test therapeutic entities to minimize neurological injury using a large animal model of birth asphyxia.
    TOMORROW: pediaTric use Of Macitentan tO delay disease pRogRessiOn in PAH Worldwide
    Actelion Pharmaceuticals Ltd AC-055-312Apr 5, 2018 - Apr 5, 2023
    Role: Site Lead
    Role Description: This is an industry-sponsored clinical trial to assess efficacy, safety and pharmacokinetics of macitentan versus standard of care in children with pulmonary arterial hypertension (PAH).
    PPHNet BiOspecimen Laboratory Depot (PPHNet-BOLD)
    Cardiovascular Medical Research and Education Fund (Vanderbilt University Medical Center) VUMC64032Oct 1, 2017 - Sep 30, 2021
    Role: Site Lead
    Role Description: The major goal of this project is to establish a biospecimen repository linked to the phenotyped PPHNet reigestiry. This will provide ar esource of DNA, RNA, plasma, serum, and circulating peripheral blood mononuclear cells for investigators studying pediatric PH.
    Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass
    NIH R44HD094414Aug 1, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Perinatal NO signaling in congenital heart disease
    NIH R01HL137282Apr 1, 2017 - Feb 28, 2021
    Role: Co-Principal Investigator
    Research Training in Pediatric Critical Care Medicine
    NIH T32HD049303Apr 1, 2005 - Apr 30, 2022
    Role: Principal Investigator
    Perinatal Pulmonary Hypertension: Developmental Mediators
    NIH R01HL061284Jul 1, 1999 - Mar 31, 2018
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality. J Med Genet. 2021 Sep 07. Machado R, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong J, Nogee L, Romer LH, Vesel S, Graf S, Morrell N, Southgate L, Chung W. PMID: 34493544.
      View in: PubMed   Mentions:    Fields:    
    2. Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU. Am J Respir Crit Care Med. 2021 08 15; 204(4):454-461. Morell E, Gaies M, Fineman JR, Charpie J, Rao R, Sasaki J, Zhang W, Reichle G, Banerjee M, Tabbutt S. PMID: 33798036.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension. J Pediatr Pharmacol Ther. 2021; 26(5):512-516. Colglazier E, Ng AJ, Parker C, Nawaytou H, Fineman JR. PMID: 34239406.
      View in: PubMed   Mentions:
    4. Characterisation of Pediatric Pulmonary Hypertensive Vascular Disease from the PPHNet Registry. Eur Respir J. 2021 Jun 17. Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Usha Raj J, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD, Pediatric Pulmonary Hypertension Network . PMID: 34140292.
      View in: PubMed   Mentions:    Fields:    
    5. Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant. Nat Biotechnol. 2021 07; 39(7):855-864. Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM. PMID: 33782610.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Pulmonary Arteriovenous Malformations and the Hepatic "Black Box": Are We Emerging From the Darkness? JACC Basic Transl Sci. 2021 Mar; 6(3):236-238. Rajagopal SK, Fineman JR. PMID: 33779631.
      View in: PubMed   Mentions:
    7. Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers. Pulm Circ. 2021 Jan-Mar; 11(1):2045894021991446. Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD. PMID: 33623667.
      View in: PubMed   Mentions:
    8. Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH. Pulm Pharmacol Ther. 2020 12; 65:101998. Acosta MF, Muralidhran P, Abrahamson MD, Grijalva CL, Carver M, Tang H, Klinger C, Fineman JR, Black SM, Mansour HM. PMID: 33556627.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Sci Rep. 2021 01 14; 11(1):1468. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. PMID: 33446832.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy. Ther Adv Respir Dis. 2021 Jan-Dec; 15:1753466621998245. Acosta MF, Muralidharan P, Grijalva CL, Abrahamson MD, Hayes D, Fineman JR, Black SM, Mansour HM. PMID: 33719747.
      View in: PubMed   Mentions: 1     Fields:    
    11. Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system. Nitric Oxide. 2021 03 01; 108:12-19. Wu X, Sun X, Sharma S, Lu Q, Yegambaram M, Hou Y, Wang T, Fineman JR, Black SM. PMID: 33338599.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales? Am J Respir Crit Care Med. 2020 12 01; 202(11):1587-1589. Amin EK, Austin ED, Parker C, Colglazier E, Nawaytou H, Leary PJ, Hemnes AR, Teitel D, Fineman JR. PMID: 32692583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. AAPS J. 2020 11 16; 23(1):2. Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM. PMID: 33200330.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox Biol. 2021 01; 38:101785. Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 33221570.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox Biol. 2020 09; 36:101679. Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM. PMID: 32818797.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    16. Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. J Cardiovasc Pharmacol. 2020 07; 76(1):94-100. Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA. PMID: 32398473.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    17. The many faces and outcomes of pulmonary vein stenosis in early childhood. Pediatr Pulmonol. 2021 03; 56(3):649-655. Humpl T, Fineman J, Qureshi AM. PMID: 32506838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research. Am J Respir Crit Care Med. 2020 06 01; 201(11):1326-1327. Oishi P, Fineman JR. PMID: 32271615.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis. Redox Biol. 2020 09; 36:101593. Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, Wang T, Fineman JR, Black SM. PMID: 32554303.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    20. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020922118. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. PMID: 32489641.
      View in: PubMed   Mentions:
    21. Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension. Pediatr Crit Care Med. 2020 03; 21(3):256-266. Morell E, Rajagopal SK, Oishi P, Thiagarajan RR, Fineman JR, Steurer MA. PMID: 31577693.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Clinical Utility of Echocardiography in Former Preterm Infants with Bronchopulmonary Dysplasia. J Am Soc Echocardiogr. 2020 03; 33(3):378-388.e1. Nawaytou H, Steurer MA, Zhao Y, Guslits E, Teitel D, Fineman JR, Keller RL. PMID: 31948712.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age. Pediatr Pulmonol. 2019 11; 54(11):1844-1852. Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA. PMID: 31328432.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Pulm Circ. 2019 Jul-Sep; 9(3):2045894019856471. Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK. PMID: 31215336.
      View in: PubMed   Mentions:
    25. EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice. Pulm Circ. 2019 May 30; 2045894019857533. Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, Kumar Rahit M, Krishnan U, Adatia ITK, Moledina S, Abman S, Cerro Marin MJD. PMID: 31144586.
      View in: PubMed   Mentions:
    26. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. Am J Respir Cell Mol Biol. 2019 05; 60(5):503-514. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. PMID: 30620615.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury. Front Physiol. 2019; 10:511. Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T. PMID: 31105595.
      View in: PubMed   Mentions:
    28. Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization. Pediatr Pulmonol. 2019 06; 54(6):804-813. Steurer MA, Nawaytou H, Guslits E, Colglazier E, Teitel D, Fineman JR, Keller RL. PMID: 30938937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. Antioxid Redox Signal. 2019 10 20; 31(12):819-842. Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 30623676.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2019 Jan; 17(1):e3000119. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30677022.
      View in: PubMed   Mentions: 1     Fields:    
    31. Two patients with FOXF1 mutations with alveolar capillary dysplasia with misalignment of pulmonary veins and other malformations: Two different presentations and outcomes. . 2018 12; 176(12):2877-2881. Abu-El-Haija A, Fineman J, Connolly AJ, Murali P, Judge LM, Slavotinek AM. PMID: 30380203.
      View in: PubMed   Mentions:
    32. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2018 10; 16(10):e2005924. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30335746.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    33. Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension. Pediatr Crit Care Med. 2018 08; 19(8):733-740. Balkin EM, Zinter MS, Rajagopal SK, Keller RL, Fineman JR, Steurer MA. PMID: 29923941.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success. J Pediatr. 2018 09; 200:277-284. Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH. PMID: 30055815.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. . 2018 10 01; 315(4):H847-H854. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. PMID: 29906222.
      View in: PubMed   Mentions:
    36. KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. . 2018 07 01; 315(1):H173-H181. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. PMID: 29631374; PMCID: PMC6087778.
      View in: PubMed   Mentions:
    37. The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. J Pediatr. 2018 06; 197:17-22. Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet) . PMID: 29628412.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    38. Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension. Int J Cardiol. 2018 08 01; 264:153-157. Levy M, Del Cerro MJ, Nadaud S, Vadlamudi K, Colgazier E, Fineman J, Bonnet D, Adatia I. PMID: 29650343.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit. Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745785. Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman JR. PMID: 29251545.
      View in: PubMed   Mentions:
    40. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Oct; 18(10):931-934. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. PMID: 28723882.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    41. Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. Leuk Lymphoma. 2018 06; 59(6):1494-1497. Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR. PMID: 28958195.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease. Pulm Circ. 2017 Jul-Sep; 7(3):747-751. Kameny RJ, Colglazier E, Nawaytou H, Moore P, Reddy VM, Teitel D, Fineman JR. PMID: 28862067.
      View in: PubMed   Mentions:
    43. Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. J Pediatr. 2017 09; 188:24-34.e1. Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet) . PMID: 28645441.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    44. Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. Pediatr Pulmonol. 2017 08; 52(8):1063-1070. Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I. PMID: 28152279.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    45. The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 15; 194(10):1186-1187. Kameny RJ, Fineman JR. PMID: 27845583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. . 2016 10 01; 311(4):H944-H957. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. PMID: 27591215.
      View in: PubMed   Mentions:
    47. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. J Pediatr. 2016 Oct; 177:90-96.e3. Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M, FUTURE-4 study investigators . PMID: 27502103.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    48. Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol. 2016 08; 55(2):275-87. Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM. PMID: 26959555.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Pulmonary Hypertension. Pediatr Crit Care Med. 2016 08; 17(8 Suppl 1):S140-5. Oishi P, Fineman JR. PMID: 27490592.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    50. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. . 2016 07 01; 311(1):H137-45. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. PMID: 27199125.
      View in: PubMed   Mentions:
    51. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One. 2016; 11(3):e0150480. Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM. PMID: 26937637.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    52. Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension. Pediatr Cardiol. 2016 Apr; 37(4):756-64. Balkin EM, Olson ED, Robertson L, Adatia I, Fineman JR, Keller RL. PMID: 26843461.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    53. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1). Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. PMID: 26738788.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2016 Mar; 170:312-4. Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH. PMID: 26703869.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    55. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitatio . PMID: 26534956.
      View in: PubMed   Mentions: 197     Fields:    Translation:Humans
    56. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. PMID: 26565914.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
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    93. Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease. Circulation. 2011 Mar 01; 123(8):916-23. Fratz S, Fineman JR, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM. PMID: 21357846.
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    96. Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal. 2010 Aug 15; 13(4):399-412. Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A. PMID: 20001745.
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    98. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. . 2010 Jun; 298(6):L880-7. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. PMID: 20363848.
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    100. Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. DNA Cell Biol. 2010 Mar; 29(3):149-60. Fonseca FV, Ravi K, Wiseman D, Tummala M, Harmon C, Ryzhov V, Fineman JR, Black SM. PMID: 20184449.
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    101. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. PMID: 19830720.
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    102. Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology. Am J Cardiol. 2009 Nov 01; 104(9):1280-4. Shah A, Feraco AM, Harmon C, Tacy T, Fineman JR, Bernstein HS. PMID: 19840577.
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    103. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics. 2009 Dec 30; 40(1):48-60. Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman JR, She JX, Black SM. PMID: 19825830.
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    104. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. PMID: 19818875.
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    129. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. . 2005 May; 288(5):L950-7. Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA. PMID: 15640287.
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    130. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med. 2004 Nov; 5(6):571-7. Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR. PMID: 15530195.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    131. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. . 2005 Jan; 288(1):L27-35. Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. PMID: 15347565.
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    132. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. . 2004 Sep; 287(3):L592-7. Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR. PMID: 15155268.
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    133. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med. 2004 May; 5(3):234-9. Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR. PMID: 15115560.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    134. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. Ann Thorac Surg. 2004 May; 77(5):1727-33. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. PMID: 15111174.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    135. Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs. J Thorac Cardiovasc Surg. 2004 May; 127(5):1285-92. Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman JR. PMID: 15115984.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    136. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7. Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. PMID: 14987351.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    137. Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life. . 2004 Jun; 286(6):L1237-43. Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman JR, Gutierrez JA. PMID: 14751849.
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    138. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatr Crit Care Med. 2004 Jan; 5(1):94-6. Oishi P, Fineman JR. PMID: 14709984.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    139. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation. 2003 Sep 30; 108(13):1646-54. Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman JR. PMID: 12963646.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    140. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. . 2003 Sep; 285(3):L628-33. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA. PMID: 12765879.
      View in: PubMed   Mentions:
    141. Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. . 2003 Jul; 285(1):L209-21. Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman JR, Black SM. PMID: 12665463.
      View in: PubMed   Mentions:
    142. Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. . 2003 Jul; 285(1):L222-31. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM. PMID: 12665467.
      View in: PubMed   Mentions:
    143. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. . 2003 Apr; 284(4):L650-62. Wedgwood S, Mitchell CJ, Fineman JR, Black SM. PMID: 12533439.
      View in: PubMed   Mentions:
    144. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. . 2003 Feb; 284(2):H480-90. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman JR. PMID: 12399254.
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    145. Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. . 2002 Dec; 283(6):L1210-9. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman JR. PMID: 12388350.
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    146. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res. 2002 Aug; 52(2):233-44. Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR. PMID: 12149501.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    147. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. . 2002 Mar; 282(3):H862-71. Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. PMID: 11834480.
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    148. Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow. . 2001 Nov; 281(5):L1264-70. Gutierrez JA, Parry AJ, McMullan DM, Chapin CJ, Fineman JR. PMID: 11597919.
      View in: PubMed   Mentions:
    149. sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. . 2001 Nov; 281(5):L1051-7. Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR. PMID: 11597895.
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    150. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circ Res. 2001 Aug 17; 89(4):357-64. Wedgwood S, McMullan DM, Bekker JM, Fineman JR, Black SM. PMID: 11509453.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    151. Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. . 2001 Feb; 280(2):H777-85. McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. PMID: 11158977.
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    152. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet. 2001 Jan 13; 357(9250):118-20. Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR. PMID: 11197402.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    153. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. . 2001 Jan; 280(1):H311-7. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR. PMID: 11123246.
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    154. Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow. Circulation. 2000 Nov 07; 102(19 Suppl 3):III172-8. McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman JR. PMID: 11082382.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    155. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Crit Care Med. 2000 Aug; 28(8):2997-3001. Flori HR, Johnson LD, Hanley FL, Fineman JR. PMID: 10966285.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    156. Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants. Crit Care Med. 2000 Apr; 28(4):1180-4. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman JR, Hanley FL. PMID: 10809302.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    157. Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. J Am Coll Cardiol. 2000 Feb; 35(2):463-7. Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR. PMID: 10676695.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    158. Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2000 Jan; 47(1):97-106. Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR. PMID: 10625089.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    159. Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension. Am J Physiol. 1999 11; 277(5):H1849-56. Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman JR. PMID: 10564139.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    160. The pathophysiology of pulmonary hypertension in congenital heart disease. Artif Organs. 1999 Nov; 23(11):970-4. Steinhorn RH, Fineman JR. PMID: 10564299.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    161. Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization. J Perinatol. 1999 Sep; 19(6 Pt 1):441-6. Hintz SR, Vincent JA, Pitlick PT, Fineman JR, Steinhorn RH, Kim GE, Benitz WE. PMID: 10685275.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    162. Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension. Pediatr Pulmonol. 1999 Jul; 28(1):3-11. Heidersbach RS, Johengen MJ, Bekker JM, Fineman JR. PMID: 10406044.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    163. Altered endothelial function in lambs with pulmonary hypertension and acute lung injury. Pediatr Pulmonol. 1999 Mar; 27(3):147-56. Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ. PMID: 10213252.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    164. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):314-23. Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman JR. PMID: 9918974.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    165. Role of the endothelium in placental dysfunction after fetal cardiac bypass. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):343-51. Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman JR, Hanley FL. PMID: 9918976.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    166. Endothelin-receptor blockade does not alter closure of the ductus arteriosus. Am J Physiol. 1998 11; 275(5):H1620-6. Fineman JR, Takahashi Y, Roman C, Clyman RI. PMID: 9815069.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    167. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol. 1998 11; 275(5):H1643-51. Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ. PMID: 9815072.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    168. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesth Analg. 1998 Jul; 87(1):46-51. Russell IA, Zwass MS, Fineman JR, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK. PMID: 9661544.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    169. Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb. Chest. 1998 Jul; 114(1 Suppl):39S. Black S, Fineman J, Johengen M, Bristow J, Soifer S. PMID: 9676621.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    170. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. Semin Perinatol. 1997 Oct; 21(5):393-408. Steinhorn RH, Morin FC, Fineman JR. PMID: 9352612.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    171. Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. J Pediatr. 1997 Mar; 130(3):417-22. Steinhorn RH, Cox PN, Fineman JR, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC. PMID: 9063417.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    172. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997 Feb 27; 336(9):605-10. Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. PMID: 9032045.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansCTClinical Trials
    173. Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1. Circulation. 1997 Feb 18; 95(4):1054-61. Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman JR. PMID: 9054770.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    174. Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero. J Am Coll Cardiol. 1996 Dec; 28(7):1877-83. Reddy VM, Liddicoat JR, McElhinney DB, Fineman JR, Klein JR, Chang R, Hanley FL. PMID: 8962579.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    175. Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period. J Thorac Cardiovasc Surg. 1996 Aug; 112(2):437-49. Reddy VM, Liddicoat JR, Fineman JR, McElhinney DB, Klein JR, Hanley FL. PMID: 8751513.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    176. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1996 Aug; 271(2 Pt 2):H562-70. Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman JR. PMID: 8770097.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    177. Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J Urol. 1996 Aug; 156(2 Pt 2):847-53. Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman JR, Heymann MA. PMID: 8683799.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    178. Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatr Res. 1996 Jul; 40(1):152-7. Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman JR. PMID: 8798262.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    179. Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins". J Appl Physiol (1985). 1996 Feb; 80(2):388-9. Fineman JR, Taeusch HW. PMID: 8929573.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    180. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1965-72. Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman JR. PMID: 8594905.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    181. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta Paediatr Jpn. 1995 Aug; 37(4):425-30. Fineman JR, Zwass MS. PMID: 7572140.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    182. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation. 1995 Aug 01; 92(3):606-13. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman JR. PMID: 7634475.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    183. Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. J Cardiovasc Pharmacol. 1995 Feb; 25(2):207-15. Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR. PMID: 7752646.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    184. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol. 1995; 57:115-34. Fineman JR, Soifer SJ, Heymann MA. PMID: 7778860.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    185. Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics. 1994 Nov; 94(5):715-8. Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman JR, Morin FC. PMID: 7936901.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    186. Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects. Circulation. 1994 Sep; 90(3):1287-93. Brook MM, Fineman JR, Bolinger AM, Wong AF, Heymann MA, Soifer SJ. PMID: 8087937.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    187. Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatr Res. 1994 Sep; 36(3):394-401. Wong J, Vanderford PA, Fineman JR, Soifer SJ. PMID: 7808838.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    188. Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J Clin Invest. 1994 Jun; 93(6):2675-83. Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ. PMID: 8201005.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    189. The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatr Res. 1994 Jun; 35(6):664-70. Wong J, Fineman JR, Heymann MA. PMID: 7936815.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    190. HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs. J Cardiovasc Pharmacol. 1994 May; 23(5):806-13. Crowley MR, Fineman JR, Soifer SJ. PMID: 7521465.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    191. Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs. J Cardiovasc Pharmacol. 1994 Jan; 23(1):113-9. Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR. PMID: 7511722.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    192. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1318-25. Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ. PMID: 8238420.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    193. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr Res. 1993 Apr; 33(4 Pt 1):341-6. Fineman JR, Wong J, Soifer SJ. PMID: 8479813.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    194. Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S262-6. Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR. PMID: 7509961.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    195. M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. Am J Physiol. 1993 Jan; 264(1 Pt 2):H252-8. Braner DA, Fineman JR, Chang R, Soifer SJ. PMID: 8381611.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    196. EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. J Appl Physiol (1985). 1992 Nov; 73(5):2151-7. Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA. PMID: 1474097.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    197. K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide. J Appl Physiol (1985). 1992 Jul; 73(1):188-94. Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA. PMID: 1506367.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    198. EDRF inhibition augments pulmonary hypertension in intact newborn lambs. Am J Physiol. 1992 May; 262(5 Pt 2):H1365-71. Fineman JR, Chang R, Soifer SJ. PMID: 1590440.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    199. L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1563-9. Fineman JR, Chang R, Soifer SJ. PMID: 1659228.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    200. In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue. J Appl Physiol (1985). 1991 Aug; 71(2):735-41. Fineman JR, Crowley MR, Heymann MA, Soifer SJ. PMID: 1657862.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    201. N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. Am J Physiol. 1991 Apr; 260(4 Pt 2):H1299-306. Fineman JR, Heymann MA, Soifer SJ. PMID: 1849373.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    202. Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs. Pediatr Res. 1991 Feb; 29(2):167-72. Crowley MR, Fineman JR, Soifer SJ. PMID: 2014153.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    203. The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation. Semin Perinatol. 1991 Feb; 15(1):58-62. Fineman JR, Soifer SJ, Heymann MA. PMID: 2063230.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    204. Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs. J Appl Physiol (1985). 1990 Nov; 69(5):1836-42. Fineman JR, Crowley MR, Soifer SJ. PMID: 2272976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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