Jeffrey Fineman, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street, #5506
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    New York University School of Medicine, New York, NYMD06/1984Medicine
    NYU/Bellevue, New York, NY06/1987Pediatric Residency
    NYU/Bellevue, New York, NY06/1988Pediatric Chief Resident
    UCSF, San Francisco, CA06/1990Pediatric Critical Care Fellowship
    UCSF, San Francisco, CA2021Diversity, Equity, Inclusion Champion Training

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    Collapse Research Activities and Funding
    OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield
    Dept. of the Army - USAMRAA 12865254-DM190076Sep 30, 2020 - Sep 29, 2023
    Role: Co-I
    Description: We propose that OMX-CV represent a unique class of precision oxygen delivery biotherapeutics with the potential to dramatically decrease reliance on conventional blood products during the treatment of hemorrhagic shock in the battlefield setting.
    Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease
    NIH/NHLBI (University of Arizona) 1P01HL146369-01A1Aug 10, 2020 - Jul 31, 2025
    Role: Co-investigator – Core C Director and Project 1 Leader
    Description: As part of this program project, Dr. Fineman will create animal models of Congenital Heart Disease, perform whole animal experiments to complement the cellular and molecular studies of the program project, and generate primary cell culture lines derived from the animal models.
    Large Mammal Neuroprotective Clinical Platform
    Bill and Melinda Gates Foundation OPP1196539Aug 1, 2018 - Jul 31, 2022
    Role: Co-Investigator
    Description: The major goals of this project are to test therapeutic entities to minimize neurological injury using a large animal model of birth asphyxia.
    TOMORROW: pediaTric use Of Macitentan tO delay disease pRogRessiOn in PAH Worldwide
    Actelion Pharmaceuticals Ltd AC-055-312Apr 5, 2018 - Apr 5, 2023
    Role: Site Lead
    Description: This is an industry-sponsored clinical trial to assess efficacy, safety and pharmacokinetics of macitentan versus standard of care in children with pulmonary arterial hypertension (PAH).
    PPHNet BiOspecimen Laboratory Depot (PPHNet-BOLD)
    Cardiovascular Medical Research and Education Fund (Vanderbilt University Medical Center) VUMC64032Oct 1, 2017 - Sep 30, 2021
    Role: Site Lead
    Description: The major goal of this project is to establish a biospecimen repository linked to the phenotyped PPHNet reigestiry. This will provide ar esource of DNA, RNA, plasma, serum, and circulating peripheral blood mononuclear cells for investigators studying pediatric PH.
    Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass
    NIH R44HD094414Aug 1, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Perinatal NO signaling in congenital heart disease
    NIH R01HL137282Apr 1, 2017 - Feb 28, 2021
    Role: Co-Principal Investigator
    Research Training in Pediatric Critical Care Medicine
    NIH T32HD049303Apr 1, 2005 - Apr 30, 2022
    Role: Principal Investigator
    Perinatal Pulmonary Hypertension: Developmental Mediators
    NIH R01HL061284Jul 1, 1999 - Mar 31, 2018
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pre-eclampsia and barker's hypothesis: are we beginning to see the trees within the forest? Pediatr Res. 2024 May 31. Tsoi SM, Steurer M, Maltepe E, Fineman JR. PMID: 38822134.
      View in: PubMed   Mentions:    Fields:    
    2. Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn: When to Think Beyond Reversible Causes. J Pediatr. 2024 May 31; 273:114131. Tsoi SM, Steurer M, Nawaytou H, Cheung S, Keller RL, Fineman JR. PMID: 38823627.
      View in: PubMed   Mentions:    Fields:    
    3. Pulmonary hypertension in the intensive care unit after pediatric allogeneic hematopoietic stem cell transplant: incidence, risk factors, and outcomes. Front Oncol. 2024; 14:1415984. Smith MA, Cheng G, Phelan R, Brazauskas R, Strom J, Ahn KW, Hamilton BK, Peterson A, Savani B, Schoemans H, Schoettler ML, Sorror M, Keller RL, Higham CS, Dvorak CC, Fineman JR, Zinter MS. PMID: 38868534; PMCID: PMC11167102.
      View in: PubMed   Mentions:
    4. Management of pulmonary vascular disease associated with congenital left-to-right shunts: A single-center experience. J Thorac Cardiovasc Surg. 2024 May 18. Nawaytou H, Lakkaraju R, Stevens L, Reddy VM, Swami N, Keller RL, Teitel DF, Fineman JR. PMID: 38763305.
      View in: PubMed   Mentions:    Fields:    
    5. Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling. Free Radic Biol Med. 2024 Aug 20; 221:125-135. Pokharel MD, Fu P, Garcia-Flores A, Yegambaram M, Lu Q, Sun X, Unwalla H, Aggarwal S, Fineman JR, Wang T, Black SM. PMID: 38734269; PMCID: PMC11179967.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. OMX: A NOVEL OXYGEN DELIVERY BIOTHERAPEUTIC IMPROVES OUTCOMES IN AN OVINE MODEL OF CONTROLLED HEMORRHAGIC SHOCK. Shock. 2024 Jul 01; 62(1):103-110. Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR. PMID: 38662597.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. A single institution anesthetic experience with catheterization of pediatric pulmonary hypertension patients. Pulm Circ. 2024 Apr; 14(2):e12360. Morell E, Colglazier E, Becerra J, Stevens L, Steurer MA, Sharma A, Nguyen H, Kathiriya IS, Weston S, Teitel D, Keller R, Amin EK, Nawaytou H, Fineman JR. PMID: 38618291; PMCID: PMC11010955.
      View in: PubMed   Mentions:
    8. VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS. Eur Respir J. 2024 Apr 04. Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V. PMID: 38575157.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials. Pulm Circ. 2024 Jan; 14(1):e12339. Avitabile CM, Krishnan US, Yung D, Handler SS, Varghese N, Bates A, Fineman J, Sullivan R, Friere G, Austin E, Mullen MP, Pereira C, Christensen EJ, Yenokyan G, Collaco JM, Abman SH, Romer L, Dunbar Ivy D, Rosenzweig EB. PMID: 38464344; PMCID: PMC10923039.
      View in: PubMed   Mentions:
    10. Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics. Redox Biol. 2024 Apr; 70:103049. Pokharel MD, Garcia-Flores A, Marciano D, Franco MC, Fineman JR, Aggarwal S, Wang T, Black SM. PMID: 38295575; PMCID: PMC10844980.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells. Int J Mol Sci. 2023 Dec 15; 24(24). Yegambaram M, Sun X, Flores AG, Lu Q, Soto J, Richards J, Aggarwal S, Wang T, Gu H, Fineman JR, Black SM. PMID: 38139362; PMCID: PMC10744129.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation. Nitric Oxide. 2024 Jan 01; 142:58-68. Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM. PMID: 38061411; PMCID: PMC11045265.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn. Pediatr Pulmonol. 2024 Feb; 59(2):379-388. Tsoi SM, Nawaytou H, Almeneisi H, Steurer M, Zhao Y, Fineman JR, Keller RL. PMID: 37975485; PMCID: PMC10872594.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III. Free Radic Biol Med. 2024 01; 210:183-194. Yegambaram M, Sun X, Lu Q, Jin Y, Ornatowski W, Soto J, Aggarwal S, Wang T, Tieu K, Gu H, Fineman JR, Black SM. PMID: 37979892.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension. Pulm Circ. 2023 Oct; 13(4):e12305. Collaco JM, Abman SH, Austin ED, Avitabile CM, Bates A, Fineman JR, Freire GA, Handler SS, Ivy DD, Krishnan US, Mullen MP, Varghese NP, Yung D, Nies MK, Everett AD, Zimmerman KO, Simmons W, Chakraborty H, Yenokyan G, Newell-Sturdivant A, Christensen E, Eyzaguirre LM, Hanley DF, Rosenzweig EB, Romer LH. PMID: 37915400; PMCID: PMC10617301.
      View in: PubMed   Mentions:
    16. Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Children (Basel). 2023 Oct 25; 10(11). Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E. PMID: 38002819; PMCID: PMC10670092.
      View in: PubMed   Mentions: 1  
    17. Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Stroke. 2023 11; 54(11):2864-2874. Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Wu YW, Fineman JR, Ferriero DM, Maltepe E. PMID: 37846563; PMCID: PMC10589434.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series. Pulm Circ. 2023 Jul; 13(3):e12289. Colglazier E, Ng AJ, Parker C, Woolsey D, Holmes R, Dsouza A, Becerra J, Stevens L, Nawaytou H, Keller RL, Fineman JR. PMID: 37731624; PMCID: PMC10507570.
      View in: PubMed   Mentions: 1  
    19. Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1. Nitric Oxide. 2023 Nov 01; 140-141:50-57. Yegambaram M, Kumar S, Wu X, Lu Q, Sun X, Garcia Flores A, Meadows ML, Barman S, Fulton D, Wang T, Fineman JR, Black SM. PMID: 37659679.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Associated radiation exposure from medical imaging and excess lifetime risk of developing cancer in pediatric patients with pulmonary hypertension. Pulm Circ. 2023 Jul; 13(3):e12282. Mahendra M, Chu P, Amin EK, Nawaytou H, Duncan JR, Fineman JR, Smith-Bindman R. PMID: 37614831; PMCID: PMC10442605.
      View in: PubMed   Mentions:
    21. Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension. J Pediatr. 2023 11; 262:113639. Avitabile CM, Yung D, Handler S, Hopper RK, Fineman J, Freire G, Varghese N, Mullen MP, Krishnan US, Austin E, Silveira L, Ivy DD. PMID: 37517653.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Metabolic reprogramming, oxidative stress, and pulmonary hypertension. Redox Biol. 2023 08; 64:102797. Pokharel MD, Marciano DP, Fu P, Franco MC, Unwalla H, Tieu K, Fineman JR, Wang T, Black SM. PMID: 37392518; PMCID: PMC10363484.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure. Front Physiol. 2023; 14:1188824. Soares JHN, Raff GW, Fineman JR, Datar SA. PMID: 37362431; PMCID: PMC10288580.
      View in: PubMed   Mentions:
    24. Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. Eur Respir J. 2023 06; 61(6). Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA. PMID: 37024132; PMCID: PMC10259331.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    25. Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission. J Biol Chem. 2023 04; 299(4):103067. Lu Q, Sun X, Yegambaram M, Ornatowski W, Wu X, Wang H, Garcia-Flores A, Da Silva V, Zemskov EA, Tang H, Fineman JR, Tieu K, Wang T, Black SM. PMID: 36841483; PMCID: PMC10060112.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Hemodynamic assessment of transitioning from parenteral prostacyclin to selexipag in pediatric pulmonary hypertension. Pulm Circ. 2022 Oct; 12(4):e12159. Colglazier E, Stevens L, Parker C, Nawaytou HM, Amin EK, Becerra J, Steurer M, Fineman JR. PMID: 36514390; PMCID: PMC9732384.
      View in: PubMed   Mentions:
    27. Predictability and stability testing to assess clinical decision instrument performance for children after blunt torso trauma. PLOS Digit Health. 2022 Aug; 1(8):e0000076. Kornblith AE, Singh C, Devlin G, Addo N, Streck CJ, Holmes JF, Kuppermann N, Grupp-Phelan J, Fineman J, Butte AJ, Yu B. PMID: 36812570; PMCID: PMC9931266.
      View in: PubMed   Mentions: 1  
    28. Caveolin-1 associated with severe (pediatric-onset) presentation of pulmonary arterial hypertension. Pulm Circ. 2022 Jul; 12(3):e12100. Farrell R, Colglazier E, Parker C, Stevens L, Austin ED, Fineman JR. PMID: 35864912; PMCID: PMC9294289.
      View in: PubMed   Mentions: 2  
    29. Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant. Pulm Circ. 2022 Jul; 12(3):e12108. Tsoi SM, Jones K, Colglazier E, Parker C, Nawaytou H, Teitel D, Fineman JR, Keller RL. PMID: 35874850; PMCID: PMC9297023.
      View in: PubMed   Mentions: 2  
    30. Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension. Ann Am Thorac Soc. 2022 06; 19(6):1000-1012. Rosenzweig EB, Bates A, Mullen MP, Abman SH, Austin ED, Everett A, Fineman J, Feinstein J, Hopper RK, Kinsella JP, Krishnan US, Lu M, Mandl KD, Raj JU, Varghese N, Yung D, Handler SS, Sleeper LA. PMID: 35049414; PMCID: PMC9169121.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Progress in Pulmonary Vein Stenosis: Lessons from Success in Treating Pulmonary Arterial Hypertension. Children (Basel). 2022 May 29; 9(6). Jenkins KJ, Fineman JR. PMID: 35740736; PMCID: PMC9222029.
      View in: PubMed   Mentions:
    32. Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia. Dev Neurosci. 2022; 44(4-5):277-294. Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E. PMID: 35588703; PMCID: PMC9474697.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    33. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2022 05 16; 132(10). Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. PMID: 35575096; PMCID: PMC9106337.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    34. Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network. Pulm Circ. 2022 Jan; 12(1):e12031. Handler SS, Varghese NP, Rosenzweig EB, Yung D, Krishnan U, Whalen E, Bates A, Avitabile CM, Jackson EO, Hirsch R, Fineman J, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). PMID: 35506071; PMCID: PMC9052968.
      View in: PubMed   Mentions: 1  
    35. Genetics dictating therapeutic decisions in pediatric pulmonary hypertension? A case report suggesting we are getting closer. Pulm Circ. 2022 Jan; 12(1):e12033. Stevens L, Colglazier E, Parker C, Amin EK, Nawaytou H, Teitel D, Reddy VM, Welch CL, Chung WK, Fineman JR. PMID: 35506084; PMCID: PMC9052973.
      View in: PubMed   Mentions: 3  
    36. Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry. Eur Respir J. 2022 01; 59(1). Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Raj JU, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD, Pediatric Pulmonary Hypertension Network. PMID: 34140292; PMCID: PMC10335325.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    37. Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery. Pharmaceutics. 2021 Dec 17; 13(12). Muralidharan P, Hayes D, Fineman JR, Black SM, Mansour HM. PMID: 34959469; PMCID: PMC8707591.
      View in: PubMed   Mentions: 1  
    38. Insights into the impact of sections and departments on your career: The APS-SPR Virtual Chat Series. Pediatr Res. 2022 09; 92(3):662-670. Davis SD, Fineman JR, St Geme Iii JW. PMID: 34824399; PMCID: PMC8614070.
      View in: PubMed   Mentions: 1     Fields:    
    39. Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality. J Med Genet. 2022 09; 59(9):906-911. Machado RD, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong JE, Nogee L, Romer LH, Vesel S, NIHR Bioresource – Rare Diseases, Gräf S, Morrell NW, Southgate L, Chung WK. PMID: 34493544; PMCID: PMC9411922.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    40. Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU. Am J Respir Crit Care Med. 2021 08 15; 204(4):454-461. Morell E, Gaies M, Fineman JR, Charpie J, Rao R, Sasaki J, Zhang W, Reichle G, Banerjee M, Tabbutt S. PMID: 33798036.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension. J Pediatr Pharmacol Ther. 2021; 26(5):512-516. Colglazier E, Ng AJ, Parker C, Nawaytou H, Fineman JR. PMID: 34239406; PMCID: PMC8244952.
      View in: PubMed   Mentions: 2  
    42. Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant. Nat Biotechnol. 2021 07; 39(7):855-864. Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM. PMID: 33782610.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    43. Pulmonary Arteriovenous Malformations and the Hepatic "Black Box": Are We Emerging From the Darkness? JACC Basic Transl Sci. 2021 Mar; 6(3):236-238. Rajagopal SK, Fineman JR. PMID: 33779631; PMCID: PMC7987538.
      View in: PubMed   Mentions: 1  
    44. Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers. Pulm Circ. 2021 Jan-Mar; 11(1):2045894021991446. Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD. PMID: 33623667; PMCID: PMC7879002.
      View in: PubMed   Mentions: 1  
    45. Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH. Pulm Pharmacol Ther. 2020 12; 65:101998. Acosta MF, Muralidhran P, Abrahamson MD, Grijalva CL, Carver M, Tang H, Klinger C, Fineman JR, Black SM, Mansour HM. PMID: 33556627; PMCID: PMC8985976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    46. HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Sci Rep. 2021 01 14; 11(1):1468. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. PMID: 33446832; PMCID: PMC7809484.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy. Ther Adv Respir Dis. 2021 Jan-Dec; 15:1753466621998245. Acosta MF, Muralidharan P, Grijalva CL, Abrahamson MD, Hayes D, Fineman JR, Black SM, Mansour HM. PMID: 33719747; PMCID: PMC7968029.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    48. Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system. Nitric Oxide. 2021 03 01; 108:12-19. Wu X, Sun X, Sharma S, Lu Q, Yegambaram M, Hou Y, Wang T, Fineman JR, Black SM. PMID: 33338599; PMCID: PMC8193791.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales? Am J Respir Crit Care Med. 2020 12 01; 202(11):1587-1589. Amin EK, Austin ED, Parker C, Colglazier E, Nawaytou H, Leary PJ, Hemnes AR, Teitel D, Fineman JR. PMID: 32692583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    50. Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. AAPS J. 2020 11 16; 23(1):2. Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM. PMID: 33200330; PMCID: PMC7669792.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    51. Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox Biol. 2021 01; 38:101785. Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 33221570; PMCID: PMC7691184.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    52. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox Biol. 2020 09; 36:101679. Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM. PMID: 32818797; PMCID: PMC7451718.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    53. Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. J Cardiovasc Pharmacol. 2020 07; 76(1):94-100. Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA. PMID: 32398473.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
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    117. Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):572-5. Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T, Pediatric Pulmonary Hypertension Network (PPHNet). PMID: 23220921.
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    118. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. PMID: 23128423; PMCID: PMC3977665.
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    119. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. PMID: 22961274; PMCID: PMC3574568.
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    122. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. PMID: 22614905; PMCID: PMC3651824.
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    123. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med. 2012 Jul 15; 53(2):216-29. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM. PMID: 22583703; PMCID: PMC3527085.
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    124. Racial disparities in congenital heart disease: beyond red and blue. Pediatr Crit Care Med. 2012 Mar; 13(2):218-9. Soskolne G, Collins JW, Fineman JR, Fuentes-Afflick E. PMID: 22391831.
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    126. Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. Am J Cardiol. 2012 Mar 15; 109(6):866-72. Lowenthal A, Camacho BV, Lowenthal S, Natal-Hernandez L, Liszewski W, Hills NK, Fineman JR, Bernstein HS. PMID: 22196786; PMCID: PMC3294194.
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    127. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011 Dec; 226(12):3104-13. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM. PMID: 21351102; PMCID: PMC3527072.
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    129. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert Opin Pharmacother. 2011 Aug; 12(12):1845-64. Oishi P, Datar SA, Fineman JR. PMID: 21609302.
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    130. Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease. Circulation. 2011 Mar 01; 123(8):916-23. Fratz S, Fineman JR, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM. PMID: 21357846; PMCID: PMC3873774.
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    132. Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb. Trends Cardiovasc Med. 2010 Oct; 20(7):238-46. Aggarwal S, Gross C, Fineman JR, Black SM. PMID: 22293025; PMCID: PMC3527074.
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    133. Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal. 2010 Aug 15; 13(4):399-412. Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A. PMID: 20001745.
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    134. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug 15; 182(4):555-61. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR. PMID: 20413632; PMCID: PMC2937245.
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    135. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L880-7. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. PMID: 20363848; PMCID: PMC2886608.
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    137. Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. DNA Cell Biol. 2010 Mar; 29(3):149-60. Fonseca FV, Ravi K, Wiseman D, Tummala M, Harmon C, Ryzhov V, Fineman JR, Black SM. PMID: 20184449; PMCID: PMC2883531.
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    138. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. PMID: 19830720; PMCID: PMC4427345.
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    139. Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology. Am J Cardiol. 2009 Nov 01; 104(9):1280-4. Shah A, Feraco AM, Harmon C, Tacy T, Fineman JR, Bernstein HS. PMID: 19840577; PMCID: PMC2791782.
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    140. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics. 2009 Dec 30; 40(1):48-60. Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman JR, She JX, Black SM. PMID: 19825830; PMCID: PMC2807211.
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    141. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. PMID: 19818875; PMCID: PMC2879580.
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    142. Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia. Am J Cardiol. 2009 Mar 15; 103(6):862-6. Natarajan S, Heiss C, Yeghiazarians Y, Fineman JR, Teitel DF, Tacy TA. PMID: 19268746.
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    143. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L756-66. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. PMID: 18757524; PMCID: PMC2584884.
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    144. Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection. J Thorac Cardiovasc Surg. 2008 Apr; 135(4):746-53. Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman JR. PMID: 18374751.
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    145. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L46-56. Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman JR, Black SM. PMID: 18024721; PMCID: PMC3970936.
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    147. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. J Thorac Cardiovasc Surg. 2007 Nov; 134(5):1179-87. Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. PMID: 17976447.
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    149. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol. 2007 Dec; 293(6):L1444-53. Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman JR, Black SM. PMID: 17827253.
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    150. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L960-71. Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. PMID: 17631609.
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    151. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1491-7. Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR. PMID: 17513498; PMCID: PMC2111047.
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    152. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2007 Jan; 61(1):32-6. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM. PMID: 17211137.
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    153. Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide. Clin Hemorheol Microcirc. 2007; 37(1-2):111-20. Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman JR. PMID: 17641401.
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    154. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. PMID: 17006391.
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    155. Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo. J Thorac Cardiovasc Surg. 2006 Dec; 132(6):1262-71. Azakie A, Fineman JR, He Y. PMID: 17140938.
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    156. Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension. J Card Fail. 2006 Sep; 12(7):507-13. Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman JR, Chatterjee K, Michaels AD. PMID: 16952783.
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    157. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vascul Pharmacol. 2006 Nov; 45(5):308-16. Black SM, Fineman JR. PMID: 17049313.
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    158. BNP for pediatrics--not quite ready for primetime. Pediatr Crit Care Med. 2006 Jul; 7(4):388-9. Oishi PE, Fineman JR. PMID: 16829829.
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    159. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1069-77. Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. PMID: 16684951.
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    160. Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H600-11. Azakie A, Fineman JR, He Y. PMID: 16617124.
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    161. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8. Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR. PMID: 16515916.
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    162. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1922-32. Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR. PMID: 16339822.
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    163. Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L359-66. Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. PMID: 16258003.
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    164. Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1522-34. Azakie A, Lamont L, Fineman JR, He Y. PMID: 16049055.
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    165. Endothelin-1 in congenital heart disease. Pediatr Res. 2005 May; 57(5 Pt 2):16R-20R. Beghetti M, Black SM, Fineman JR. PMID: 15817494.
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    166. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L950-7. Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA. PMID: 15640287.
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    167. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med. 2004 Nov; 5(6):571-7. Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR. PMID: 15530195.
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    168. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L27-35. Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. PMID: 15347565.
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    169. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L592-7. Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR. PMID: 15155268.
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    170. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med. 2004 May; 5(3):234-9. Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR. PMID: 15115560.
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    171. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. Ann Thorac Surg. 2004 May; 77(5):1727-33. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. PMID: 15111174.
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    172. Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs. J Thorac Cardiovasc Surg. 2004 May; 127(5):1285-92. Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman JR. PMID: 15115984.
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    173. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7. Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. PMID: 14987351.
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    174. Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1237-43. Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman JR, Gutierrez JA. PMID: 14751849.
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    175. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatr Crit Care Med. 2004 Jan; 5(1):94-6. Oishi P, Fineman JR. PMID: 14709984.
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    176. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation. 2003 Sep 30; 108(13):1646-54. Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman JR. PMID: 12963646.
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    177. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L628-33. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA. PMID: 12765879.
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    178. Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L209-21. Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman JR, Black SM. PMID: 12665463.
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    179. Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L222-31. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM. PMID: 12665467.
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    180. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L650-62. Wedgwood S, Mitchell CJ, Fineman JR, Black SM. PMID: 12533439.
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    181. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H480-90. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman JR. PMID: 12399254.
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    182. Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. Am J Physiol Lung Cell Mol Physiol. 2002 Dec; 283(6):L1210-9. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman JR. PMID: 12388350.
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    183. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res. 2002 Aug; 52(2):233-44. Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR. PMID: 12149501.
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    184. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H862-71. Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. PMID: 11834480.
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    185. Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1264-70. Gutierrez JA, Parry AJ, McMullan DM, Chapin CJ, Fineman JR. PMID: 11597919.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    186. sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1051-7. Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR. PMID: 11597895.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    187. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circ Res. 2001 Aug 17; 89(4):357-64. Wedgwood S, McMullan DM, Bekker JM, Fineman JR, Black SM. PMID: 11509453.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    188. Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H777-85. McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. PMID: 11158977.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    189. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet. 2001 Jan 13; 357(9250):118-20. Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR. PMID: 11197402.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    190. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H311-7. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR. PMID: 11123246.
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    191. Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow. Circulation. 2000 Nov 07; 102(19 Suppl 3):III172-8. McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman JR. PMID: 11082382.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    192. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Crit Care Med. 2000 Aug; 28(8):2997-3001. Flori HR, Johnson LD, Hanley FL, Fineman JR. PMID: 10966285.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    193. Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants. Crit Care Med. 2000 Apr; 28(4):1180-4. McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman JR, Hanley FL. PMID: 10809302.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    194. Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. J Am Coll Cardiol. 2000 Feb; 35(2):463-7. Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR. PMID: 10676695.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    195. Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2000 Jan; 47(1):97-106. Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR. PMID: 10625089.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    196. Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension. Am J Physiol. 1999 11; 277(5):H1849-56. Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman JR. PMID: 10564139.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    197. The pathophysiology of pulmonary hypertension in congenital heart disease. Artif Organs. 1999 Nov; 23(11):970-4. Steinhorn RH, Fineman JR. PMID: 10564299.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    198. Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization. J Perinatol. 1999 Sep; 19(6 Pt 1):441-6. Hintz SR, Vincent JA, Pitlick PT, Fineman JR, Steinhorn RH, Kim GE, Benitz WE. PMID: 10685275.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    199. Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension. Pediatr Pulmonol. 1999 Jul; 28(1):3-11. Heidersbach RS, Johengen MJ, Bekker JM, Fineman JR. PMID: 10406044.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    200. Altered endothelial function in lambs with pulmonary hypertension and acute lung injury. Pediatr Pulmonol. 1999 Mar; 27(3):147-56. Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ. PMID: 10213252.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    201. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):314-23. Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman JR. PMID: 9918974.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    202. Role of the endothelium in placental dysfunction after fetal cardiac bypass. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):343-51. Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman JR, Hanley FL. PMID: 9918976.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    203. Endothelin-receptor blockade does not alter closure of the ductus arteriosus. Am J Physiol. 1998 11; 275(5):H1620-6. Fineman JR, Takahashi Y, Roman C, Clyman RI. PMID: 9815069.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    204. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol. 1998 11; 275(5):H1643-51. Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ. PMID: 9815072.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    205. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesth Analg. 1998 Jul; 87(1):46-51. Russell IA, Zwass MS, Fineman JR, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK. PMID: 9661544.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    206. Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb. Chest. 1998 Jul; 114(1 Suppl):39S. Black S, Fineman J, Johengen M, Bristow J, Soifer S. PMID: 9676621.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    207. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. Semin Perinatol. 1997 Oct; 21(5):393-408. Steinhorn RH, Morin FC, Fineman JR. PMID: 9352612.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    208. Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. J Pediatr. 1997 Mar; 130(3):417-22. Steinhorn RH, Cox PN, Fineman JR, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC. PMID: 9063417.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    209. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997 Feb 27; 336(9):605-10. Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. PMID: 9032045.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCTClinical Trials
    210. Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1. Circulation. 1997 Feb 18; 95(4):1054-61. Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman JR. PMID: 9054770.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    211. Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero. J Am Coll Cardiol. 1996 Dec; 28(7):1877-83. Reddy VM, Liddicoat JR, McElhinney DB, Fineman JR, Klein JR, Chang R, Hanley FL. PMID: 8962579.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    212. Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period. J Thorac Cardiovasc Surg. 1996 Aug; 112(2):437-49. Reddy VM, Liddicoat JR, Fineman JR, McElhinney DB, Klein JR, Hanley FL. PMID: 8751513.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    213. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1996 Aug; 271(2 Pt 2):H562-70. Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman JR. PMID: 8770097.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    214. Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J Urol. 1996 Aug; 156(2 Pt 2):847-53. Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman JR, Heymann MA. PMID: 8683799.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    215. Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatr Res. 1996 Jul; 40(1):152-7. Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman JR. PMID: 8798262.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    216. Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins". J Appl Physiol (1985). 1996 Feb; 80(2):388-9. Fineman JR, Taeusch HW. PMID: 8929573.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    217. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1965-72. Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman JR. PMID: 8594905.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    218. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta Paediatr Jpn. 1995 Aug; 37(4):425-30. Fineman JR, Zwass MS. PMID: 7572140.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    219. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation. 1995 Aug 01; 92(3):606-13. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman JR. PMID: 7634475.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    220. Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. J Cardiovasc Pharmacol. 1995 Feb; 25(2):207-15. Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR. PMID: 7752646.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    221. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol. 1995; 57:115-34. Fineman JR, Soifer SJ, Heymann MA. PMID: 7778860.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    222. Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics. 1994 Nov; 94(5):715-8. Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman JR, Morin FC. PMID: 7936901.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    223. Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects. Circulation. 1994 Sep; 90(3):1287-93. Brook MM, Fineman JR, Bolinger AM, Wong AF, Heymann MA, Soifer SJ. PMID: 8087937.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    224. Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatr Res. 1994 Sep; 36(3):394-401. Wong J, Vanderford PA, Fineman JR, Soifer SJ. PMID: 7808838.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    225. Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J Clin Invest. 1994 Jun; 93(6):2675-83. Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ. PMID: 8201005; PMCID: PMC294514.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    226. The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatr Res. 1994 Jun; 35(6):664-70. Wong J, Fineman JR, Heymann MA. PMID: 7936815.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    227. HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs. J Cardiovasc Pharmacol. 1994 May; 23(5):806-13. Crowley MR, Fineman JR, Soifer SJ. PMID: 7521465.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    228. Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs. J Cardiovasc Pharmacol. 1994 Jan; 23(1):113-9. Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR. PMID: 7511722.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    229. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1318-25. Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ. PMID: 8238420.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    230. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr Res. 1993 Apr; 33(4 Pt 1):341-6. Fineman JR, Wong J, Soifer SJ. PMID: 8479813.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    231. Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S262-6. Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR. PMID: 7509961.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    232. M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. Am J Physiol. 1993 Jan; 264(1 Pt 2):H252-8. Braner DA, Fineman JR, Chang R, Soifer SJ. PMID: 8381611.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    233. EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. J Appl Physiol (1985). 1992 Nov; 73(5):2151-7. Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA. PMID: 1474097.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    234. K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide. J Appl Physiol (1985). 1992 Jul; 73(1):188-94. Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA. PMID: 1506367.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    235. EDRF inhibition augments pulmonary hypertension in intact newborn lambs. Am J Physiol. 1992 May; 262(5 Pt 2):H1365-71. Fineman JR, Chang R, Soifer SJ. PMID: 1590440.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    236. L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1563-9. Fineman JR, Chang R, Soifer SJ. PMID: 1659228.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    237. In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue. J Appl Physiol (1985). 1991 Aug; 71(2):735-41. Fineman JR, Crowley MR, Heymann MA, Soifer SJ. PMID: 1657862.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    238. N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. Am J Physiol. 1991 Apr; 260(4 Pt 2):H1299-306. Fineman JR, Heymann MA, Soifer SJ. PMID: 1849373.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    239. Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs. Pediatr Res. 1991 Feb; 29(2):167-72. Crowley MR, Fineman JR, Soifer SJ. PMID: 2014153.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    240. The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation. Semin Perinatol. 1991 Feb; 15(1):58-62. Fineman JR, Soifer SJ, Heymann MA. PMID: 2063230.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    241. Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs. J Appl Physiol (1985). 1990 Nov; 69(5):1836-42. Fineman JR, Crowley MR, Soifer SJ. PMID: 2272976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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