Jeff Fineman, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    New York University School of Medicine, New York, NYMD06/1984Medicine
    NYU/Bellevue, New York, NY06/1987Pediatric Residency
    NYU/Bellevue, New York, NY06/1988Pediatric Chief Resident
    UCSF, San Francisco, CA06/1990Pediatric Critical Care Fellowship
    UCSF, San Francisco, CA2021Diversity, Equity, Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield
    Dept. of the Army - USAMRAA 12865254-DM190076Sep 30, 2020 - Sep 29, 2023
    Role: Co-I
    Description: We propose that OMX-CV represent a unique class of precision oxygen delivery biotherapeutics with the potential to dramatically decrease reliance on conventional blood products during the treatment of hemorrhagic shock in the battlefield setting.
    Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease
    NIH/NHLBI (University of Arizona) 1P01HL146369-01A1Aug 10, 2020 - Jul 31, 2025
    Role: Co-investigator – Core C Director and Project 1 Leader
    Description: As part of this program project, Dr. Fineman will create animal models of Congenital Heart Disease, perform whole animal experiments to complement the cellular and molecular studies of the program project, and generate primary cell culture lines derived from the animal models.
    Large Mammal Neuroprotective Clinical Platform
    Bill and Melinda Gates Foundation OPP1196539Aug 1, 2018 - Jul 31, 2022
    Role: Co-Investigator
    Description: The major goals of this project are to test therapeutic entities to minimize neurological injury using a large animal model of birth asphyxia.
    TOMORROW: pediaTric use Of Macitentan tO delay disease pRogRessiOn in PAH Worldwide
    Actelion Pharmaceuticals Ltd AC-055-312Apr 5, 2018 - Apr 5, 2023
    Role: Site Lead
    Description: This is an industry-sponsored clinical trial to assess efficacy, safety and pharmacokinetics of macitentan versus standard of care in children with pulmonary arterial hypertension (PAH).
    PPHNet BiOspecimen Laboratory Depot (PPHNet-BOLD)
    Cardiovascular Medical Research and Education Fund (Vanderbilt University Medical Center) VUMC64032Oct 1, 2017 - Sep 30, 2021
    Role: Site Lead
    Description: The major goal of this project is to establish a biospecimen repository linked to the phenotyped PPHNet reigestiry. This will provide ar esource of DNA, RNA, plasma, serum, and circulating peripheral blood mononuclear cells for investigators studying pediatric PH.
    Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass
    NIH R44HD094414Aug 1, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Perinatal NO signaling in congenital heart disease
    NIH R01HL137282Apr 1, 2017 - Feb 28, 2021
    Role: Co-Principal Investigator
    Research Training in Pediatric Critical Care Medicine
    NIH T32HD049303Apr 1, 2005 - Apr 30, 2022
    Role: Principal Investigator
    Perinatal Pulmonary Hypertension: Developmental Mediators
    NIH R01HL061284Jul 1, 1999 - Mar 31, 2018
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension. Ann Am Thorac Soc. 2022 Jun; 19(6):1000-1012. Rosenzweig EB, Bates A, Mullen MP, Abman SH, Austin ED, Everett A, Fineman J, Feinstein J, Hopper RK, Kinsella JP, Krishnan US, Lu M, Mandl KD, Raj JU, Varghese N, Yung D, Handler SS, Sleeper LA. PMID: 35049414.
      View in: PubMed   Mentions:
    2. Defining longer term outcomes in an ovine model of moderate perinatal hypoxia-ischemia. Dev Neurosci. 2022 May 19. Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JV, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E. PMID: 35588703.
      View in: PubMed   Mentions:
    3. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2022 May 16; 132(10). Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. PMID: 35575096; PMCID: PMC9106337.
      View in: PubMed   Mentions:
    4. Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network. Pulm Circ. 2022 Jan; 12(1):e12031. Handler SS, Varghese NP, Rosenzweig EB, Yung D, Krishnan U, Whalen E, Bates A, Avitabile CM, Jackson EO, Hirsch R, Fineman J, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). PMID: 35506071; PMCID: PMC9052968.
      View in: PubMed   Mentions:
    5. Genetics dictating therapeutic decisions in pediatric pulmonary hypertension? A case report suggesting we are getting closer. Pulm Circ. 2022 Jan; 12(1):e12033. Stevens L, Colglazier E, Parker C, Amin EK, Nawaytou H, Teitel D, Reddy VM, Welch CL, Chung WK, Fineman JR. PMID: 35506084; PMCID: PMC9052973.
      View in: PubMed   Mentions:
    6. Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry. Eur Respir J. 2022 01; 59(1). Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Raj JU, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD, Pediatric Pulmonary Hypertension Network. PMID: 34140292.
      View in: PubMed   Mentions: 1     Fields:    
    7. Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery. Pharmaceutics. 2021 Dec 17; 13(12). Muralidharan P, Hayes D, Fineman JR, Black SM, Mansour HM. PMID: 34959469; PMCID: PMC8707591.
      View in: PubMed   Mentions:
    8. Insights into the impact of sections and departments on your career: The APS-SPR Virtual Chat Series. Pediatr Res. 2021 Nov 25. Davis SD, Fineman JR, St Geme Iii JW. PMID: 34824399; PMCID: PMC8614070.
      View in: PubMed   Mentions:
    9. Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality. J Med Genet. 2021 Sep 07. Machado RD, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong JE, Nogee L, Romer LH, Vesel S, NIHR Bioresource – Rare Diseases, Gräf S, Morrell NW, Southgate L, Chung WK. PMID: 34493544.
      View in: PubMed   Mentions:    Fields:    
    10. Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU. Am J Respir Crit Care Med. 2021 08 15; 204(4):454-461. Morell E, Gaies M, Fineman JR, Charpie J, Rao R, Sasaki J, Zhang W, Reichle G, Banerjee M, Tabbutt S. PMID: 33798036.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension. J Pediatr Pharmacol Ther. 2021; 26(5):512-516. Colglazier E, Ng AJ, Parker C, Nawaytou H, Fineman JR. PMID: 34239406; PMCID: PMC8244952.
      View in: PubMed   Mentions:
    12. Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant. Nat Biotechnol. 2021 07; 39(7):855-864. Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM. PMID: 33782610.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Pulmonary Arteriovenous Malformations and the Hepatic "Black Box": Are We Emerging From the Darkness? JACC Basic Transl Sci. 2021 Mar; 6(3):236-238. Rajagopal SK, Fineman JR. PMID: 33779631; PMCID: PMC7987538.
      View in: PubMed   Mentions:
    14. Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers. Pulm Circ. 2021 Jan-Mar; 11(1):2045894021991446. Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD. PMID: 33623667; PMCID: PMC7879002.
      View in: PubMed   Mentions:
    15. Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH. Pulm Pharmacol Ther. 2020 12; 65:101998. Acosta MF, Muralidhran P, Abrahamson MD, Grijalva CL, Carver M, Tang H, Klinger C, Fineman JR, Black SM, Mansour HM. PMID: 33556627; PMCID: PMC8985976.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Sci Rep. 2021 01 14; 11(1):1468. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. PMID: 33446832; PMCID: PMC7809484.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy. Ther Adv Respir Dis. 2021 Jan-Dec; 15:1753466621998245. Acosta MF, Muralidharan P, Grijalva CL, Abrahamson MD, Hayes D, Fineman JR, Black SM, Mansour HM. PMID: 33719747; PMCID: PMC7968029.
      View in: PubMed   Mentions: 1     Fields:    
    18. Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system. Nitric Oxide. 2021 03 01; 108:12-19. Wu X, Sun X, Sharma S, Lu Q, Yegambaram M, Hou Y, Wang T, Fineman JR, Black SM. PMID: 33338599; PMCID: PMC8193791.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales? Am J Respir Crit Care Med. 2020 12 01; 202(11):1587-1589. Amin EK, Austin ED, Parker C, Colglazier E, Nawaytou H, Leary PJ, Hemnes AR, Teitel D, Fineman JR. PMID: 32692583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. AAPS J. 2020 11 16; 23(1):2. Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM. PMID: 33200330; PMCID: PMC7669792.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox Biol. 2021 01; 38:101785. Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 33221570; PMCID: PMC7691184.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox Biol. 2020 09; 36:101679. Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM. PMID: 32818797; PMCID: PMC7451718.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. J Cardiovasc Pharmacol. 2020 07; 76(1):94-100. Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA. PMID: 32398473.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    24. The many faces and outcomes of pulmonary vein stenosis in early childhood. Pediatr Pulmonol. 2021 03; 56(3):649-655. Humpl T, Fineman J, Qureshi AM. PMID: 32506838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research. Am J Respir Crit Care Med. 2020 06 01; 201(11):1326-1327. Oishi P, Fineman JR. PMID: 32271615; PMCID: PMC7258640.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis. Redox Biol. 2020 09; 36:101593. Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, Wang T, Fineman JR, Black SM. PMID: 32554303; PMCID: PMC7303661.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020922118. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. PMID: 32489641; PMCID: PMC7238833.
      View in: PubMed   Mentions:
    28. Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension. Pediatr Crit Care Med. 2020 03; 21(3):256-266. Morell E, Rajagopal SK, Oishi P, Thiagarajan RR, Fineman JR, Steurer MA. PMID: 31577693.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Clinical Utility of Echocardiography in Former Preterm Infants with Bronchopulmonary Dysplasia. J Am Soc Echocardiogr. 2020 03; 33(3):378-388.e1. Nawaytou H, Steurer MA, Zhao Y, Guslits E, Teitel D, Fineman JR, Keller RL. PMID: 31948712.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age. Pediatr Pulmonol. 2019 11; 54(11):1844-1852. Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA. PMID: 31328432.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Pulm Circ. 2019 Jul-Sep; 9(3):2045894019856471. Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK. PMID: 31215336; PMCID: PMC6628532.
      View in: PubMed   Mentions: 2  
    32. EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice. Pulm Circ. 2019 May 30; 2045894019857533. Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, Kumar Rahit M, Krishnan U, Adatia ITK, Moledina S, Abman S, Cerro Marin MJD. PMID: 31144586; PMCID: PMC6886286.
      View in: PubMed   Mentions: 2  
    33. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. Am J Respir Cell Mol Biol. 2019 05; 60(5):503-514. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. PMID: 30620615; PMCID: PMC6503613.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury. Front Physiol. 2019; 10:511. Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T. PMID: 31105595; PMCID: PMC6498899.
      View in: PubMed   Mentions: 5  
    35. Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization. Pediatr Pulmonol. 2019 06; 54(6):804-813. Steurer MA, Nawaytou H, Guslits E, Colglazier E, Teitel D, Fineman JR, Keller RL. PMID: 30938937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. Antioxid Redox Signal. 2019 10 20; 31(12):819-842. Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 30623676; PMCID: PMC6751394.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2019 Jan; 17(1):e3000119. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30677022; PMCID: PMC6345423.
      View in: PubMed   Mentions: 1     Fields:    
    38. Two patients with FOXF1 mutations with alveolar capillary dysplasia with misalignment of pulmonary veins and other malformations: Two different presentations and outcomes. Am J Med Genet A. 2018 12; 176(12):2877-2881. Abu-El-Haija A, Fineman J, Connolly AJ, Murali P, Judge LM, Slavotinek AM. PMID: 30380203.
      View in: PubMed   Mentions: 3  Translation:Humans
    39. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2018 10; 16(10):e2005924. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30335746; PMCID: PMC6193608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    40. Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension. Pediatr Crit Care Med. 2018 08; 19(8):733-740. Balkin EM, Zinter MS, Rajagopal SK, Keller RL, Fineman JR, Steurer MA. PMID: 29923941; PMCID: PMC6086734.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success. J Pediatr. 2018 09; 200:277-284. Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH. PMID: 30055815.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H847-H854. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. PMID: 29906222; PMCID: PMC6230913.
      View in: PubMed   Mentions: 7  Translation:AnimalsCells
    43. KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H173-H181. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. PMID: 29631374; PMCID: PMC6087778.
      View in: PubMed   Mentions: 2  Translation:AnimalsCells
    44. The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. J Pediatr. 2018 06; 197:17-22. Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). PMID: 29628412.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    45. Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension. Int J Cardiol. 2018 08 01; 264:153-157. Levy M, Del Cerro MJ, Nadaud S, Vadlamudi K, Colgazier E, Fineman J, Bonnet D, Adatia I. PMID: 29650343.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    46. Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit. Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745785. Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman JR. PMID: 29251545; PMCID: PMC5753928.
      View in: PubMed   Mentions: 4  
    47. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Oct; 18(10):931-934. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. PMID: 28723882; PMCID: PMC5628126.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    48. Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. Leuk Lymphoma. 2018 06; 59(6):1494-1497. Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR. PMID: 28958195; PMCID: PMC5897181.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease. Pulm Circ. 2017 Jul-Sep; 7(3):747-751. Kameny RJ, Colglazier E, Nawaytou H, Moore P, Reddy VM, Teitel D, Fineman JR. PMID: 28862067; PMCID: PMC5841911.
      View in: PubMed   Mentions: 1  
    50. Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. J Pediatr. 2017 09; 188:24-34.e1. Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). PMID: 28645441.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    51. Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. Pediatr Pulmonol. 2017 08; 52(8):1063-1070. Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I. PMID: 28152279.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    52. The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 15; 194(10):1186-1187. Kameny RJ, Fineman JR. PMID: 27845583; PMCID: PMC5114444.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 10 01; 311(4):H944-H957. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. PMID: 27591215; PMCID: PMC5114466.
      View in: PubMed   Mentions: 10  Translation:AnimalsCells
    54. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. J Pediatr. 2016 Oct; 177:90-96.e3. Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M, FUTURE-4 study investigators. PMID: 27502103.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
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    117. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. J Thorac Cardiovasc Surg. 2007 Nov; 134(5):1179-87. Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. PMID: 17976447.
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    118. B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):939-45. Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. PMID: 17903511.
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    119. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol. 2007 Dec; 293(6):L1444-53. Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman JR, Black SM. PMID: 17827253.
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    120. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L960-71. Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. PMID: 17631609.
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    121. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1491-7. Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR. PMID: 17513498; PMCID: PMC2111047.
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    122. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2007 Jan; 61(1):32-6. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM. PMID: 17211137.
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    123. Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide. Clin Hemorheol Microcirc. 2007; 37(1-2):111-20. Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman JR. PMID: 17641401.
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    124. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. PMID: 17006391.
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    125. Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo. J Thorac Cardiovasc Surg. 2006 Dec; 132(6):1262-71. Azakie A, Fineman JR, He Y. PMID: 17140938.
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    126. Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension. J Card Fail. 2006 Sep; 12(7):507-13. Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman JR, Chatterjee K, Michaels AD. PMID: 16952783.
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    127. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vascul Pharmacol. 2006 Nov; 45(5):308-16. Black SM, Fineman JR. PMID: 17049313.
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    128. BNP for pediatrics--not quite ready for primetime. Pediatr Crit Care Med. 2006 Jul; 7(4):388-9. Oishi PE, Fineman JR. PMID: 16829829.
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    129. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1069-77. Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. PMID: 16684951.
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    130. Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H600-11. Azakie A, Fineman JR, He Y. PMID: 16617124.
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    131. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8. Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR. PMID: 16515916.
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    132. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1922-32. Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR. PMID: 16339822.
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    133. Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L359-66. Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. PMID: 16258003.
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    134. Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1522-34. Azakie A, Lamont L, Fineman JR, He Y. PMID: 16049055.
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    135. Endothelin-1 in congenital heart disease. Pediatr Res. 2005 May; 57(5 Pt 2):16R-20R. Beghetti M, Black SM, Fineman JR. PMID: 15817494.
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    136. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L950-7. Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA. PMID: 15640287.
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    137. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med. 2004 Nov; 5(6):571-7. Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR. PMID: 15530195.
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    138. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L27-35. Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. PMID: 15347565.
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    139. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L592-7. Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR. PMID: 15155268.
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    140. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med. 2004 May; 5(3):234-9. Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR. PMID: 15115560.
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    141. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. Ann Thorac Surg. 2004 May; 77(5):1727-33. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. PMID: 15111174.
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    142. Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs. J Thorac Cardiovasc Surg. 2004 May; 127(5):1285-92. Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman JR. PMID: 15115984.
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    143. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7. Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. PMID: 14987351.
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    144. Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1237-43. Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman JR, Gutierrez JA. PMID: 14751849.
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    145. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatr Crit Care Med. 2004 Jan; 5(1):94-6. Oishi P, Fineman JR. PMID: 14709984.
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    146. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation. 2003 Sep 30; 108(13):1646-54. Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman JR. PMID: 12963646.
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    147. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L628-33. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA. PMID: 12765879.
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    148. Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L222-31. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM. PMID: 12665467.
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    149. Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L209-21. Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman JR, Black SM. PMID: 12665463.
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    150. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L650-62. Wedgwood S, Mitchell CJ, Fineman JR, Black SM. PMID: 12533439.
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    151. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H480-90. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman JR. PMID: 12399254.
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    152. Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. Am J Physiol Lung Cell Mol Physiol. 2002 Dec; 283(6):L1210-9. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman JR. PMID: 12388350.
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    153. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res. 2002 Aug; 52(2):233-44. Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR. PMID: 12149501.
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    154. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H862-71. Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. PMID: 11834480.
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    155. Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1264-70. Gutierrez JA, Parry AJ, McMullan DM, Chapin CJ, Fineman JR. PMID: 11597919.
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    156. sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1051-7. Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR. PMID: 11597895.
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    157. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circ Res. 2001 Aug 17; 89(4):357-64. Wedgwood S, McMullan DM, Bekker JM, Fineman JR, Black SM. PMID: 11509453.
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    158. Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H777-85. McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. PMID: 11158977.
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    159. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet. 2001 Jan 13; 357(9250):118-20. Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR. PMID: 11197402.
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    160. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H311-7. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR. PMID: 11123246.
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    161. Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow. Circulation. 2000 Nov 07; 102(19 Suppl 3):III172-8. McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman JR. PMID: 11082382.
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    162. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Crit Care Med. 2000 Aug; 28(8):2997-3001. Flori HR, Johnson LD, Hanley FL, Fineman JR. PMID: 10966285.
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    163. Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants. Crit Care Med. 2000 Apr; 28(4):1180-4. McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman JR, Hanley FL. PMID: 10809302.
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    164. Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. J Am Coll Cardiol. 2000 Feb; 35(2):463-7. Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR. PMID: 10676695.
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    165. Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2000 Jan; 47(1):97-106. Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR. PMID: 10625089.
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    166. Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension. Am J Physiol. 1999 11; 277(5):H1849-56. Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman JR. PMID: 10564139.
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    167. The pathophysiology of pulmonary hypertension in congenital heart disease. Artif Organs. 1999 Nov; 23(11):970-4. Steinhorn RH, Fineman JR. PMID: 10564299.
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    168. Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization. J Perinatol. 1999 Sep; 19(6 Pt 1):441-6. Hintz SR, Vincent JA, Pitlick PT, Fineman JR, Steinhorn RH, Kim GE, Benitz WE. PMID: 10685275.
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    169. Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension. Pediatr Pulmonol. 1999 Jul; 28(1):3-11. Heidersbach RS, Johengen MJ, Bekker JM, Fineman JR. PMID: 10406044.
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    170. Altered endothelial function in lambs with pulmonary hypertension and acute lung injury. Pediatr Pulmonol. 1999 Mar; 27(3):147-56. Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ. PMID: 10213252.
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    171. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):314-23. Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman JR. PMID: 9918974.
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    172. Role of the endothelium in placental dysfunction after fetal cardiac bypass. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):343-51. Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman JR, Hanley FL. PMID: 9918976.
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    173. Endothelin-receptor blockade does not alter closure of the ductus arteriosus. Am J Physiol. 1998 11; 275(5):H1620-6. Fineman JR, Takahashi Y, Roman C, Clyman RI. PMID: 9815069.
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    174. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol. 1998 11; 275(5):H1643-51. Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ. PMID: 9815072.
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    175. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesth Analg. 1998 Jul; 87(1):46-51. Russell IA, Zwass MS, Fineman JR, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK. PMID: 9661544.
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    176. Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb. Chest. 1998 Jul; 114(1 Suppl):39S. Black S, Fineman J, Johengen M, Bristow J, Soifer S. PMID: 9676621.
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    177. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. Semin Perinatol. 1997 Oct; 21(5):393-408. Steinhorn RH, Morin FC, Fineman JR. PMID: 9352612.
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    178. Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. J Pediatr. 1997 Mar; 130(3):417-22. Steinhorn RH, Cox PN, Fineman JR, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC. PMID: 9063417.
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    179. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997 Feb 27; 336(9):605-10. Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. PMID: 9032045.
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    180. Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1. Circulation. 1997 Feb 18; 95(4):1054-61. Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman JR. PMID: 9054770.
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    181. Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero. J Am Coll Cardiol. 1996 Dec; 28(7):1877-83. Reddy VM, Liddicoat JR, McElhinney DB, Fineman JR, Klein JR, Chang R, Hanley FL. PMID: 8962579.
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    182. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1996 Aug; 271(2 Pt 2):H562-70. Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman JR. PMID: 8770097.
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    183. Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J Urol. 1996 Aug; 156(2 Pt 2):847-53. Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman JR, Heymann MA. PMID: 8683799.
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    184. Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period. J Thorac Cardiovasc Surg. 1996 Aug; 112(2):437-49. Reddy VM, Liddicoat JR, Fineman JR, McElhinney DB, Klein JR, Hanley FL. PMID: 8751513.
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    185. Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatr Res. 1996 Jul; 40(1):152-7. Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman JR. PMID: 8798262.
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    186. Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins". J Appl Physiol (1985). 1996 Feb; 80(2):388-9. Fineman JR, Taeusch HW. PMID: 8929573.
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    187. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1965-72. Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman JR. PMID: 8594905.
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    188. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation. 1995 Aug 01; 92(3):606-13. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman JR. PMID: 7634475.
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    189. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta Paediatr Jpn. 1995 Aug; 37(4):425-30. Fineman JR, Zwass MS. PMID: 7572140.
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    190. Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. J Cardiovasc Pharmacol. 1995 Feb; 25(2):207-15. Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR. PMID: 7752646.
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    191. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol. 1995; 57:115-34. Fineman JR, Soifer SJ, Heymann MA. PMID: 7778860.
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    192. Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics. 1994 Nov; 94(5):715-8. Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman JR, Morin FC. PMID: 7936901.
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    193. Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects. Circulation. 1994 Sep; 90(3):1287-93. Brook MM, Fineman JR, Bolinger AM, Wong AF, Heymann MA, Soifer SJ. PMID: 8087937.
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    194. Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatr Res. 1994 Sep; 36(3):394-401. Wong J, Vanderford PA, Fineman JR, Soifer SJ. PMID: 7808838.
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    195. Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J Clin Invest. 1994 Jun; 93(6):2675-83. Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ. PMID: 8201005; PMCID: PMC294514.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    196. The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatr Res. 1994 Jun; 35(6):664-70. Wong J, Fineman JR, Heymann MA. PMID: 7936815.
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    197. HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs. J Cardiovasc Pharmacol. 1994 May; 23(5):806-13. Crowley MR, Fineman JR, Soifer SJ. PMID: 7521465.
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    198. Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs. J Cardiovasc Pharmacol. 1994 Jan; 23(1):113-9. Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR. PMID: 7511722.
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    199. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1318-25. Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ. PMID: 8238420.
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    200. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr Res. 1993 Apr; 33(4 Pt 1):341-6. Fineman JR, Wong J, Soifer SJ. PMID: 8479813.
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    201. M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. Am J Physiol. 1993 Jan; 264(1 Pt 2):H252-8. Braner DA, Fineman JR, Chang R, Soifer SJ. PMID: 8381611.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    202. Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S262-6. Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR. PMID: 7509961.
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    203. EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. J Appl Physiol (1985). 1992 Nov; 73(5):2151-7. Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA. PMID: 1474097.
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    204. K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide. J Appl Physiol (1985). 1992 Jul; 73(1):188-94. Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA. PMID: 1506367.
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    205. EDRF inhibition augments pulmonary hypertension in intact newborn lambs. Am J Physiol. 1992 May; 262(5 Pt 2):H1365-71. Fineman JR, Chang R, Soifer SJ. PMID: 1590440.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    206. L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1563-9. Fineman JR, Chang R, Soifer SJ. PMID: 1659228.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    207. In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue. J Appl Physiol (1985). 1991 Aug; 71(2):735-41. Fineman JR, Crowley MR, Heymann MA, Soifer SJ. PMID: 1657862.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    208. N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. Am J Physiol. 1991 Apr; 260(4 Pt 2):H1299-306. Fineman JR, Heymann MA, Soifer SJ. PMID: 1849373.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    209. Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs. Pediatr Res. 1991 Feb; 29(2):167-72. Crowley MR, Fineman JR, Soifer SJ. PMID: 2014153.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    210. The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation. Semin Perinatol. 1991 Feb; 15(1):58-62. Fineman JR, Soifer SJ, Heymann MA. PMID: 2063230.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    211. Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs. J Appl Physiol (1985). 1990 Nov; 69(5):1836-42. Fineman JR, Crowley MR, Soifer SJ. PMID: 2272976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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