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Jeffrey Fineman, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address550 16th. Street
San Francisco CA 94158
Phone415-502-6390
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    Collapse Research 
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    Research Training in Pediatric Critical Care Medicine
    NIH/NICHD T32HD049303Apr 1, 2005 - Apr 30, 2017
    Role: Principal Investigator
    Perinatal Pulmonary Hypertension: Developmental Mediators
    NIH/NHLBI R01HL061284Jul 1, 1999 - Mar 31, 2017
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kameny RJ, Fineman J. The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Nov 15; 194(10):1186-1187. PMID: 27845583.
      View in: PubMed
    2. Boehme J, Sun X, Tormos K, Gong W, Kellner M, Datar S, Johnson Kameny R, Yuan JX, Raff GW, Fineman J, Black SM, Maltepe E, et al. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 Sep 2; ajpheart.00040.2016. PMID: 27591215.
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    3. Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. J Pediatr. 2016 Oct; 177:90-96.e3. PMID: 27502103.
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    4. Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman J, Black SM. Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol. 2016 Aug; 55(2):275-87. PMID: 26959555.
      View in: PubMed
    5. Oishi P, Fineman J. Pulmonary Hypertension. Pediatr Crit Care Med. 2016 Aug; 17(8 Suppl 1):S140-5. PMID: 27490592.
      View in: PubMed
    6. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman J. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 Jul 1; 311(1):H137-45. PMID: 27199125.
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    7. Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman J, Rafikov R, Black SM. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One. 2016; 11(3):e0150480. PMID: 26937637.
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    8. Balkin EM, Olson ED, Robertson L, Adatia I, Fineman J, Keller RL. Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension. Pediatr Cardiol. 2016 Apr; 37(4):756-64. PMID: 26843461.
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    9. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman J, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016; 5(1). PMID: 26738788.
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    10. Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman J, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2016 Mar; 170:312-4. PMID: 26703869.
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    11. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman J, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99. PMID: 26534956.
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    12. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman J, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 3; 13(5):1016-32. PMID: 26565914; PMCID: PMC4644508.
    13. Rafikov R, Sun X, Rafikova O, Louise Meadows M, Desai AA, Khalpey Z, Yuan JX, Fineman J, Black SM. Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Redox Biol. 2015 Dec; 6:278-86. PMID: 26298201; PMCID: PMC4556771.
    14. Olson E, Lusk LA, Fineman J, Robertson L, Keller RL. Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair. J Pediatr. 2015 Sep; 167(3):762-4. PMID: 26143384; PMCID: PMC4554975 [Available on 09/01/16].
    15. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman J. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015 Jul 1; 309(1):H157-65. PMID: 25934095; PMCID: PMC4491525 [Available on 07/01/16].
    16. Wellnitz K, Harris IS, Sapru A, Fineman J, Radman M. Longitudinal development of obesity in the post-Fontan population. Eur J Clin Nutr. 2015 Oct; 69(10):1105-8. PMID: 25920422.
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    17. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman J, Black SM. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. J Cell Physiol. 2014 Nov; 229(11):1802-16. PMID: 24677020; PMCID: PMC4117725.
    18. Steurer MA, Moon-Grady AJ, Fineman J, Sun CE, Lusk LA, Wai KC, Keller RL. B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia. Pediatr Res. 2014 Dec; 76(6):549-54. PMID: 25188741; PMCID: PMC4232979.
    19. Char DS, Shiboski SC, Hanley FL, Fineman J. Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients with congenitally corrected transposition of the great arteries: a pilot study. J Thorac Cardiovasc Surg. 2014 Nov; 148(5):2434-6. PMID: 25135237.
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    20. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman J, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug; 124(8):3514-28. PMID: 24960162; PMCID: PMC4109523.
    21. Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman J, Black SM. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1084-95. PMID: 24392990; PMCID: PMC4068912.
    22. Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman J. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1222-30. PMID: 24561861; PMCID: PMC3989751.
    23. Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman J. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2014 Apr 1; 306(7):H954-62. PMID: 24531811; PMCID: PMC4116402.
    24. Aggarwal S, Gross CM, Rafikov R, Kumar S, Fineman J, Ludewig B, Jonigk D, Black SM. Nitration of tyrosine 247 inhibits protein kinase G-1a activity by attenuating cyclic guanosine monophosphate binding. J Biol Chem. 2014 Mar 14; 289(11):7948-61. PMID: 24469460; PMCID: PMC3953305.
    25. Rafikov R, Kumar S, Aggarwal S, Hou Y, Kangath A, Pardo D, Fineman J, Black SM. Endothelin-1 stimulates catalase activity through the PKCd-mediated phosphorylation of serine 167. Free Radic Biol Med. 2014 Feb; 67:255-64. PMID: 24211614; PMCID: PMC3945115.
    26. Shue EH, Schecter SC, Gong W, Etemadi M, Johengen M, Iqbal C, Derderian SC, Oishi P, Fineman J, Miniati D. Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jan; 49(1):39-45; discussion 45. PMID: 24439578; PMCID: PMC3896891.
    27. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman J. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul; 148(1):212-9. PMID: 24079880; PMCID: PMC3968237.
    28. Aggarwal S, Gross CM, Sharma S, Fineman J, Black SM. Reactive oxygen species in pulmonary vascular remodeling. Compr Physiol. 2013 Jul; 3(3):1011-34. PMID: 23897679; PMCID: PMC3907081.
    29. Amirnovin R, Oishi P, Fineman J, Keller RL. Reply to the editor. J Thorac Cardiovasc Surg. 2013 May; 145(5):1416. PMID: 23597627.
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    30. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman J, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res. 2013 Jul; 74(1):39-47. PMID: 23628882; PMCID: PMC3709010.
    31. Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50. PMID: 23583172; PMCID: PMC3787941.
    32. Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman J, Black SM. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxid Redox Signal. 2013 May 10; 18(14):1739-52. PMID: 23244702; PMCID: PMC3619212.
    33. Azakie A, Fineman J, He Y. Differential responses of the right ventricle to abnormal loading conditions in vivo: possible pathophysiologic mechanisms. J Thorac Cardiovasc Surg. 2013 May; 145(5):1335-44. PMID: 23434296.
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    34. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman J, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. J Cell Biochem. 2013 Feb; 114(2):435-47. PMID: 22961736; PMCID: PMC3906673.
    35. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman J, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther. 2013 Apr; 26(2):271-80. PMID: 23257346; PMCID: PMC3872991.
    36. Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T. Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):572-5. PMID: 23220921.
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    37. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman J. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61. PMID: 23128423; PMCID: PMC3977665.
    38. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman J. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5. PMID: 22961274; PMCID: PMC3574568.
    39. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman J, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PLoS One. 2012; 7(9):e41555. PMID: 22962578; PMCID: PMC3433474.
    40. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman J. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87. PMID: 22914252.
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    41. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman J. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7. PMID: 22614905; PMCID: PMC3651824.
    42. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman J, Black SM. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med. 2012 Jul 15; 53(2):216-29. PMID: 22583703; PMCID: PMC3527085.
    43. Soskolne G, Collins JW, Fineman J, Fuentes-Afflick E. Racial disparities in congenital heart disease: beyond red and blue. Pediatr Crit Care Med. 2012 Mar; 13(2):218-9. PMID: 22391831.
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    44. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman J. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L530-40. PMID: 22207591; PMCID: PMC3311527.
    45. Lowenthal A, Camacho BV, Lowenthal S, Natal-Hernandez L, Liszewski W, Hills NK, Fineman J, Bernstein HS. Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. Am J Cardiol. 2012 Mar 15; 109(6):866-72. PMID: 22196786; PMCID: PMC3294194.
    46. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman J, Black SM. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011 Dec; 226(12):3104-13. PMID: 21351102; PMCID: PMC3527072.
    47. Oishi P, Datar SA, Fineman J. Advances in the management of pediatric pulmonary hypertension. Respir Care. 2011 Sep; 56(9):1314-39; discussion 1339-40. PMID: 21944683.
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    48. Oishi P, Datar SA, Fineman J. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert Opin Pharmacother. 2011 Aug; 12(12):1845-64. PMID: 21609302.
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    49. Fratz S, Fineman J, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM. Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease. Circulation. 2011 Mar 1; 123(8):916-23. PMID: 21357846; PMCID: PMC3873774.
    50. Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman J, Black SM. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiol Genomics. 2011 Jan 1; 43(2):87-98. PMID: 20978110; PMCID: PMC3026563.
    51. Aggarwal S, Gross C, Fineman J, Black SM. Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb. Trends Cardiovasc Med. 2010 Oct; 20(7):238-46. PMID: 22293025; PMCID: PMC3527074.
    52. Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A. Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal. 2010 Aug 15; 13(4):399-412. PMID: 20001745.
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    53. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman J. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug 15; 182(4):555-61. PMID: 20413632; PMCID: PMC2937245.
    54. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman J. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L880-7. PMID: 20363848; PMCID: PMC2886608.
    55. Sharma S, Kumar S, Wiseman DA, Kallarackal S, Ponnala S, Elgaish M, Tian J, Fineman J, Black SM. Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow. Vascul Pharmacol. 2010 Jul-Aug; 53(1-2):38-52. PMID: 20362073; PMCID: PMC3815618.
    56. Fonseca FV, Ravi K, Wiseman D, Tummala M, Harmon C, Ryzhov V, Fineman J, Black SM. Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. DNA Cell Biol. 2010 Mar; 29(3):149-60. PMID: 20184449; PMCID: PMC2883531.
    57. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman J, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. PMID: 19830720; PMCID: PMC4427345.
    58. Shah A, Feraco AM, Harmon C, Tacy T, Fineman J, Bernstein HS. Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology. Am J Cardiol. 2009 Nov 1; 104(9):1280-4. PMID: 19840577; PMCID: PMC2791782.
    59. Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman J, She JX, Black SM. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics. 2009 Dec 30; 40(1):48-60. PMID: 19825830; PMCID: PMC2807211.
    60. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman J, Black SM. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64. PMID: 19818875; PMCID: PMC2879580.
    61. Natarajan S, Heiss C, Yeghiazarians Y, Fineman J, Teitel DF, Tacy TA. Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia. Am J Cardiol. 2009 Mar 15; 103(6):862-6. PMID: 19268746.
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    62. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman J, Black SM. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L756-66. PMID: 18757524; PMCID: PMC2584884.
    63. Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman J. Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection. J Thorac Cardiovasc Surg. 2008 Apr; 135(4):746-53. PMID: 18374751.
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    64. Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman J, Black SM. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L46-56. PMID: 18024721; PMCID: PMC3970936.
    65. Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman J. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. J Thorac Cardiovasc Surg. 2007 Nov; 134(5):1179-87. PMID: 17976447.
      View in: PubMed
    66. Oishi P, Sharma S, Grobe A, Azakie A, Harmon C, Johengen MJ, Hsu JH, Fratz S, Black SM, Fineman J. Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs. Pediatr Pulmonol. 2007 Nov; 42(11):1057-71. PMID: 17902145.
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    67. Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman J. B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):939-45. PMID: 17903511.
      View in: PubMed
    68. Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman J, Black SM. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol. 2007 Dec; 293(6):L1444-53. PMID: 17827253.
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    69. Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman J, Black SM. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L960-71. PMID: 17631609.
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    70. Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman J. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1491-7. PMID: 17513498; PMCID: PMC2111047.
    71. Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman J. Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide. Clin Hemorheol Microcirc. 2007; 37(1-2):111-20. PMID: 17641401.
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    72. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman J, Black SM. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2007 Jan; 61(1):32-6. PMID: 17211137.
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    73. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman J. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94. PMID: 17006391.
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    74. Azakie A, Fineman J, He Y. Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo. J Thorac Cardiovasc Surg. 2006 Dec; 132(6):1262-71. PMID: 17140938.
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    75. Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman J, Chatterjee K, Michaels AD. Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension. J Card Fail. 2006 Sep; 12(7):507-13. PMID: 16952783.
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    76. Black SM, Fineman J. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vascul Pharmacol. 2006 Nov; 45(5):308-16. PMID: 17049313.
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    77. Oishi PE, Fineman J. BNP for pediatrics--not quite ready for primetime. Pediatr Crit Care Med. 2006 Jul; 7(4):388-9. PMID: 16829829.
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    78. Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman J, Black SM. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1069-77. PMID: 16684951.
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    79. Azakie A, Fineman J, He Y. Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H600-11. PMID: 16617124.
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    80. Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman J. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8. PMID: 16515916.
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    81. Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman J. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1922-32. PMID: 16339822.
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    82. Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman J. Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L359-66. PMID: 16258003.
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    83. Azakie A, Lamont L, Fineman J, He Y. Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1522-34. PMID: 16049055.
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    84. Beghetti M, Black SM, Fineman J. Endothelin-1 in congenital heart disease. Pediatr Res. 2005 May; 57(5 Pt 2):16R-20R. PMID: 15817494.
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    85. Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman J, Gutierrez JA. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L950-7. PMID: 15640287.
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    86. Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman J. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med. 2004 Nov; 5(6):571-7. PMID: 15530195.
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    87. Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman J. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L27-35. PMID: 15347565.
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    88. Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman J. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L592-7. PMID: 15155268.
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    89. Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman J. Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs. J Thorac Cardiovasc Surg. 2004 May; 127(5):1285-92. PMID: 15115984.
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    90. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. Ann Thorac Surg. 2004 May; 77(5):1727-33. PMID: 15111174.
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    91. Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman J. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med. 2004 May; 5(3):234-9. PMID: 15115560.
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    92. Keller RL, Hamrick SE, Kitterman JA, Fineman J, Hawgood S. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7. PMID: 14987351.
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    93. Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman J, Gutierrez JA. Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1237-43. PMID: 14751849.
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    94. Oishi P, Fineman J. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatr Crit Care Med. 2004 Jan; 5(1):94-6. PMID: 14709984.
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    95. Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman J. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation. 2003 Sep 30; 108(13):1646-54. PMID: 12963646.
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    96. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman J, Gutierrez JA. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L628-33. PMID: 12765879.
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    97. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman J, Black SM. Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L222-31. PMID: 12665467.
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    98. Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman J, Black SM. Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L209-21. PMID: 12665463.
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    99. Wedgwood S, Mitchell CJ, Fineman J, Black SM. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L650-62. PMID: 12533439.
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    100. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman J. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H480-90. PMID: 12399254.
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    101. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman J. Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. Am J Physiol Lung Cell Mol Physiol. 2002 Dec; 283(6):L1210-9. PMID: 12388350.
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    102. Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman J. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res. 2002 Aug; 52(2):233-44. PMID: 12149501.
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    103. Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman J. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H862-71. PMID: 11834480.
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    104. Gutierrez JA, Parry AJ, McMullan DM, Chapin CJ, Fineman J. Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1264-70. PMID: 11597919.
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    105. Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman J. sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001 Nov; 281(5):L1051-7. PMID: 11597895.
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    106. Wedgwood S, McMullan DM, Bekker JM, Fineman J, Black SM. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circ Res. 2001 Aug 17; 89(4):357-64. PMID: 11509453.
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    107. McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman J. Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H777-85. PMID: 11158977.
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    108. Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman J. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet. 2001 Jan 13; 357(9250):118-20. PMID: 11197402.
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    109. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman J. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H311-7. PMID: 11123246.
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    110. McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman J. Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow. Circulation. 2000 Nov 7; 102(19 Suppl 3):III172-8. PMID: 11082382.
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    111. Flori HR, Johnson LD, Hanley FL, Fineman J. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Crit Care Med. 2000 Aug; 28(8):2997-3001. PMID: 10966285.
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    112. McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman J, Hanley FL. Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants. Crit Care Med. 2000 Apr; 28(4):1180-4. PMID: 10809302.
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    113. Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman J. Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. J Am Coll Cardiol. 2000 Feb; 35(2):463-7. PMID: 10676695.
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    114. Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman J. Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2000 Jan; 47(1):97-106. PMID: 10625089.
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    115. Steinhorn RH, Fineman J. The pathophysiology of pulmonary hypertension in congenital heart disease. Artif Organs. 1999 Nov; 23(11):970-4. PMID: 10564299.
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    116. Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman J. Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension. Am J Physiol. 1999 Nov; 277(5 Pt 2):H1849-56. PMID: 10564139.
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    117. Hintz SR, Vincent JA, Pitlick PT, Fineman J, Steinhorn RH, Kim GE, Benitz WE. Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization. J Perinatol. 1999 Sep; 19(6 Pt 1):441-6. PMID: 10685275.
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    118. Heidersbach RS, Johengen MJ, Bekker JM, Fineman J. Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension. Pediatr Pulmonol. 1999 Jul; 28(1):3-11. PMID: 10406044.
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    119. Fineman J, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ. Altered endothelial function in lambs with pulmonary hypertension and acute lung injury. Pediatr Pulmonol. 1999 Mar; 27(3):147-56. PMID: 10213252.
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    120. Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman J, Hanley FL. Role of the endothelium in placental dysfunction after fetal cardiac bypass. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):343-51. PMID: 9918976.
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    121. Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman J. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):314-23. PMID: 9918974.
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    122. Black SM, Fineman J, Steinhorn RH, Bristow J, Soifer SJ. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol. 1998 Nov; 275(5 Pt 2):H1643-51. PMID: 9815072.
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    123. Fineman J, Takahashi Y, Roman C, Clyman RI. Endothelin-receptor blockade does not alter closure of the ductus arteriosus. Am J Physiol. 1998 Nov; 275(5 Pt 2):H1620-6. PMID: 9815069.
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    124. Black S, Fineman J, Johengen M, Bristow J, Soifer S. Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb. Chest. 1998 Jul; 114(1 Suppl):39S. PMID: 9676621.
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    125. Russell IA, Zwass MS, Fineman J, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesth Analg. 1998 Jul; 87(1):46-51. PMID: 9661544.
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    126. Steinhorn RH, Morin FC, Fineman J. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. Semin Perinatol. 1997 Oct; 21(5):393-408. PMID: 9352612.
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    127. Steinhorn RH, Cox PN, Fineman J, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC. Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. J Pediatr. 1997 Mar; 130(3):417-22. PMID: 9063417.
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    128. Roberts JD, Fineman J, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. 1997 Feb 27; 336(9):605-10. PMID: 9032045.
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    129. Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman J. Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1. Circulation. 1997 Feb 18; 95(4):1054-61. PMID: 9054770.
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    130. Reddy VM, Liddicoat JR, McElhinney DB, Fineman J, Klein JR, Chang R, Hanley FL. Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero. J Am Coll Cardiol. 1996 Dec; 28(7):1877-83. PMID: 8962579.
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    131. Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman J. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1996 Aug; 271(2 Pt 2):H562-70. PMID: 8770097.
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    132. Reddy VM, Liddicoat JR, Fineman J, McElhinney DB, Klein JR, Hanley FL. Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period. J Thorac Cardiovasc Surg. 1996 Aug; 112(2):437-49. PMID: 8751513.
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    133. Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman J, Heymann MA. Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J Urol. 1996 Aug; 156(2 Pt 2):847-53. PMID: 8683799.
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    134. Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman J. Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatr Res. 1996 Jul; 40(1):152-7. PMID: 8798262.
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    135. Fineman J, Taeusch HW. Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins". J Appl Physiol (1985). 1996 Feb; 80(2):388-9. PMID: 8929573.
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    136. Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman J. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. 1995 Dec; 269(6 Pt 2):H1965-72. PMID: 8594905.
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    137. Fineman J, Zwass MS. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta Paediatr Jpn. 1995 Aug; 37(4):425-30. PMID: 7572140.
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    138. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman J. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation. 1995 Aug 1; 92(3):606-13. PMID: 7634475.
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    139. Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman J. Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. J Cardiovasc Pharmacol. 1995 Feb; 25(2):207-15. PMID: 7752646.
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    140. Fineman J, Soifer SJ, Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol. 1995; 57:115-34. PMID: 7778860.
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    141. Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman J, Morin FC. Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics. 1994 Nov; 94(5):715-8. PMID: 7936901.
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    142. Wong J, Vanderford PA, Fineman J, Soifer SJ. Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatr Res. 1994 Sep; 36(3):394-401. PMID: 7808838.
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    143. Brook MM, Fineman J, Bolinger AM, Wong AF, Heymann MA, Soifer SJ. Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects. Circulation. 1994 Sep; 90(3):1287-93. PMID: 8087937.
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    144. Wong J, Fineman J, Heymann MA. The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatr Res. 1994 Jun; 35(6):664-70. PMID: 7936815.
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    145. Fineman J, Wong J, Morin FC, Wild LM, Soifer SJ. Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J Clin Invest. 1994 Jun; 93(6):2675-83. PMID: 8201005; PMCID: PMC294514.
    146. Crowley MR, Fineman J, Soifer SJ. HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs. J Cardiovasc Pharmacol. 1994 May; 23(5):806-13. PMID: 7521465.
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    147. Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman J. Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs. J Cardiovasc Pharmacol. 1994 Jan; 23(1):113-9. PMID: 7511722.
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    148. Wong J, Vanderford PA, Fineman J, Chang R, Soifer SJ. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1318-25. PMID: 8238420.
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    149. Fineman J, Wong J, Soifer SJ. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatr Res. 1993 Apr; 33(4 Pt 1):341-6. PMID: 8479813.
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    150. Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman J. Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. J Cardiovasc Pharmacol. 1993; 22 Suppl 8:S262-6. PMID: 7509961.
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    151. Braner DA, Fineman J, Chang R, Soifer SJ. M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. Am J Physiol. 1993 Jan; 264(1 Pt 2):H252-8. PMID: 8381611.
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    152. Moore P, Velvis H, Fineman J, Soifer SJ, Heymann MA. EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. J Appl Physiol (1985). 1992 Nov; 73(5):2151-7. PMID: 1474097.
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    153. Chang JK, Moore P, Fineman J, Soifer SJ, Heymann MA. K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide. J Appl Physiol (1985). 1992 Jul; 73(1):188-94. PMID: 1506367.
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    154. Fineman J, Chang R, Soifer SJ. EDRF inhibition augments pulmonary hypertension in intact newborn lambs. Am J Physiol. 1992 May; 262(5 Pt 2):H1365-71. PMID: 1590440.
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    155. Fineman J, Chang R, Soifer SJ. L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1563-9. PMID: 1659228.
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    156. Fineman J, Crowley MR, Heymann MA, Soifer SJ. In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue. J Appl Physiol (1985). 1991 Aug; 71(2):735-41. PMID: 1657862.
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    157. Fineman J, Heymann MA, Soifer SJ. N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. Am J Physiol. 1991 Apr; 260(4 Pt 2):H1299-306. PMID: 1849373.
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    158. Crowley MR, Fineman J, Soifer SJ. Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs. Pediatr Res. 1991 Feb; 29(2):167-72. PMID: 2014153.
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    159. Fineman J, Soifer SJ, Heymann MA. The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation. Semin Perinatol. 1991 Feb; 15(1):58-62. PMID: 2063230.
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    160. Fineman J, Crowley MR, Soifer SJ. Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs. J Appl Physiol (1985). 1990 Nov; 69(5):1836-42. PMID: 2272976.
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