Loading...

Jeffrey Fineman, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address550 16th. Street
San Francisco CA 94158
Phone415-502-6390
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass
    NIH/NICHD R44HD094414Aug 1, 2017 - Jul 31, 2018
    Role: Co-Principal Investigator
    Perinatal NO signaling in congenital heart disease
    NIH/NHLBI R01HL137282Apr 1, 2017 - Feb 28, 2021
    Role: Co-Principal Investigator
    Research Training in Pediatric Critical Care Medicine
    NIH/NICHD T32HD049303Apr 1, 2005 - Apr 30, 2022
    Role: Principal Investigator
    Perinatal Pulmonary Hypertension: Developmental Mediators
    NIH/NHLBI R01HL061284Jul 1, 1999 - Mar 31, 2017
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme J, Hata A, Fineman J. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. Am J Physiol Heart Circ Physiol. 2018 Jun 15. PMID: 29906222.
      View in: PubMed
    2. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman J, Datar SA. KLF2-mediated Disruption of PPAR? Signaling in Lymphatic Endothelial Cells Exposed to Chronically Increased Pulmonary Lymph Flow. Am J Physiol Heart Circ Physiol. 2018 Apr 06. PMID: 29631374.
      View in: PubMed
    3. Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman J, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH. The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. J Pediatr. 2018 Apr 05. PMID: 29628412.
      View in: PubMed
    4. Levy M, Del Cerro MJ, Nadaud S, Vadlamudi K, Colgazier E, Fineman J, Bonnet D, Adatia I. Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension. Int J Cardiol. 2018 Mar 15. PMID: 29650343.
      View in: PubMed
    5. Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman J. Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit. Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745785. PMID: 29251545.
      View in: PubMed
    6. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman J. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Oct; 18(10):931-934. PMID: 28723882.
      View in: PubMed
    7. Kameny RJ, Colglazier E, Nawaytou H, Moore P, Reddy VM, Teitel D, Fineman J. Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease. Pulm Circ. 2017 Jul-Sep; 7(3):747-751. PMID: 28862067.
      View in: PubMed
    8. Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH. Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. J Pediatr. 2017 Sep; 188:24-34.e1. PMID: 28645441.
      View in: PubMed
    9. Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I. Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. Pediatr Pulmonol. 2017 Aug; 52(8):1063-1070. PMID: 28152279.
      View in: PubMed
    10. Kameny RJ, Fineman J. The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 15; 194(10):1186-1187. PMID: 27845583.
      View in: PubMed
    11. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman J, Black SM, Maltepe E. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 Oct 01; 311(4):H944-H957. PMID: 27591215.
      View in: PubMed
    12. Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. J Pediatr. 2016 Oct; 177:90-96.e3. PMID: 27502103.
      View in: PubMed
    13. Oishi P, Fineman J. Pulmonary Hypertension. Pediatr Crit Care Med. 2016 Aug; 17(8 Suppl 1):S140-5. PMID: 27490592; PMCID: PMC4975433 [Available on 08/01/17].
    14. Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman J, Black SM. Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol. 2016 08; 55(2):275-87. PMID: 26959555.
      View in: PubMed
    15. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman J. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 Jul 01; 311(1):H137-45. PMID: 27199125.
      View in: PubMed
    16. Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman J, Rafikov R, Black SM. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One. 2016; 11(3):e0150480. PMID: 26937637; PMCID: PMC4777490.
    17. Balkin EM, Olson ED, Robertson L, Adatia I, Fineman J, Keller RL. Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension. Pediatr Cardiol. 2016 Apr; 37(4):756-64. PMID: 26843461; PMCID: PMC4826405.
    18. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman J, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1). PMID: 26738788; PMCID: PMC4859354.
    19. Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman J, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2016 Mar; 170:312-4. PMID: 26703869.
      View in: PubMed
    20. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman J, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99. PMID: 26534956.
      View in: PubMed
    21. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman J, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. PMID: 26565914; PMCID: PMC4644508.
    22. Rafikov R, Sun X, Rafikova O, Meadows ML, Desai AA, Khalpey Z, Yuan JX, Fineman J, Black SM. Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Redox Biol. 2015 Dec; 6:278-86. PMID: 26298201; PMCID: PMC4556771.
    23. Olson E, Lusk LA, Fineman J, Robertson L, Keller RL. Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair. J Pediatr. 2015 Sep; 167(3):762-4. PMID: 26143384; PMCID: PMC4554975.
    24. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman J. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015 Jul 01; 309(1):H157-65. PMID: 25934095; PMCID: PMC4491525.
    25. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman J, Black SM. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. J Cell Physiol. 2014 Nov; 229(11):1802-16. PMID: 24677020; PMCID: PMC4117725.
    26. Steurer MA, Moon-Grady AJ, Fineman J, Sun CE, Lusk LA, Wai KC, Keller RL. B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia. Pediatr Res. 2014 Dec; 76(6):549-54. PMID: 25188741; PMCID: PMC4232979.
    27. Char DS, Shiboski SC, Hanley FL, Fineman J. Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients with congenitally corrected transposition of the great arteries: a pilot study. J Thorac Cardiovasc Surg. 2014 Nov; 148(5):2434-6. PMID: 25135237.
      View in: PubMed
    28. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman J, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug; 124(8):3514-28. PMID: 24960162; PMCID: PMC4109523.
    29. Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman J, Black SM. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1084-95. PMID: 24392990; PMCID: PMC4068912.
    30. Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman J. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1222-30. PMID: 24561861; PMCID: PMC3989751.
    31. Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman J. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H954-62. PMID: 24531811; PMCID: PMC4116402.
    32. Aggarwal S, Gross CM, Rafikov R, Kumar S, Fineman J, Ludewig B, Jonigk D, Black SM. Nitration of tyrosine 247 inhibits protein kinase G-1a activity by attenuating cyclic guanosine monophosphate binding. J Biol Chem. 2014 Mar 14; 289(11):7948-61. PMID: 24469460; PMCID: PMC3953305.
    33. Rafikov R, Kumar S, Aggarwal S, Hou Y, Kangath A, Pardo D, Fineman J, Black SM. Endothelin-1 stimulates catalase activity through the PKCd-mediated phosphorylation of serine 167. Free Radic Biol Med. 2014 Feb; 67:255-64. PMID: 24211614; PMCID: PMC3945115.
    34. Shue EH, Schecter SC, Gong W, Etemadi M, Johengen M, Iqbal C, Derderian SC, Oishi P, Fineman J, Miniati D. Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jan; 49(1):39-45; discussion 45. PMID: 24439578; PMCID: PMC3896891.
    35. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman J. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul; 148(1):212-9. PMID: 24079880; PMCID: PMC3968237.
    36. Aggarwal S, Gross CM, Sharma S, Fineman J, Black SM. Reactive oxygen species in pulmonary vascular remodeling. Compr Physiol. 2013 Jul; 3(3):1011-34. PMID: 23897679; PMCID: PMC3907081.
    37. Amirnovin R, Oishi P, Fineman J, Keller RL. Reply to the editor. J Thorac Cardiovasc Surg. 2013 May; 145(5):1416. PMID: 23597627.
      View in: PubMed
    38. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman J, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res. 2013 Jul; 74(1):39-47. PMID: 23628882; PMCID: PMC3709010.
    39. Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50. PMID: 23583172; PMCID: PMC3787941.
    40. Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman J, Black SM. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxid Redox Signal. 2013 May 10; 18(14):1739-52. PMID: 23244702; PMCID: PMC3619212.
    41. Azakie A, Fineman J, He Y. Differential responses of the right ventricle to abnormal loading conditions in vivo: possible pathophysiologic mechanisms. J Thorac Cardiovasc Surg. 2013 May; 145(5):1335-44. PMID: 23434296.
      View in: PubMed
    42. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman J, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. J Cell Biochem. 2013 Feb; 114(2):435-447. PMID: 22961736; PMCID: PMC3906673.
    43. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman J, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther. 2013 Apr; 26(2):271-80. PMID: 23257346; PMCID: PMC3872991.
    44. Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T. Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):572-5. PMID: 23220921.
      View in: PubMed
    45. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman J. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61. PMID: 23128423; PMCID: PMC3977665.
    46. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman J. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5. PMID: 22961274; PMCID: PMC3574568.
    47. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman J, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PLoS One. 2012; 7(9):e41555. PMID: 22962578; PMCID: PMC3433474.
    48. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman J. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87. PMID: 22914252.
      View in: PubMed
    49. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman J. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7. PMID: 22614905; PMCID: PMC3651824.
    50. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman J, Black SM. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med. 2012 Jul 15; 53(2):216-29. PMID: 22583703; PMCID: PMC3527085.
    51. Soskolne G, Collins JW, Fineman J, Fuentes-Afflick E. Racial disparities in congenital heart disease: beyond red and blue. Pediatr Crit Care Med. 2012 Mar; 13(2):218-9. PMID: 22391831.
      View in: PubMed
    52. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman J. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L530-40. PMID: 22207591; PMCID: PMC3311527.
    53. Lowenthal A, Camacho BV, Lowenthal S, Natal-Hernandez L, Liszewski W, Hills NK, Fineman J, Bernstein HS. Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. Am J Cardiol. 2012 Mar 15; 109(6):866-72. PMID: 22196786; PMCID: PMC3294194.
    54. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman J, Black SM. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011 Dec; 226(12):3104-13. PMID: 21351102; PMCID: PMC3527072.
    55. Oishi P, Datar SA, Fineman J. Advances in the management of pediatric pulmonary hypertension. Respir Care. 2011 Sep; 56(9):1314-39; discussion 1339-40. PMID: 21944683.
      View in: PubMed
    56. Oishi P, Datar SA, Fineman J. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert Opin Pharmacother. 2011 Aug; 12(12):1845-64. PMID: 21609302.
      View in: PubMed
    57. Fratz S, Fineman J, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM. Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease. Circulation. 2011 Mar 01; 123(8):916-23. PMID: 21357846; PMCID: PMC3873774.
    58. Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman J, Black SM. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiol Genomics. 2011 Jan 01; 43(2):87-98. PMID: 20978110; PMCID: PMC3026563.
    59. Aggarwal S, Gross C, Fineman J, Black SM. Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb. Trends Cardiovasc Med. 2010 Oct; 20(7):238-46. PMID: 22293025; PMCID: PMC3527074.
    60. Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A. Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal. 2010 Aug 15; 13(4):399-412. PMID: 20001745.
      View in: PubMed
    61. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman J. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug 15; 182(4):555-61. PMID: 20413632; PMCID: PMC2937245.
    62. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman J. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L880-7. PMID: 20363848; PMCID: PMC2886608.
    63. Sharma S, Kumar S, Wiseman DA, Kallarackal S, Ponnala S, Elgaish M, Tian J, Fineman J, Black SM. Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow. Vascul Pharmacol. 2010 Jul-Aug; 53(1-2):38-52. PMID: 20362073; PMCID: PMC3815618.
    64. Fonseca FV, Ravi K, Wiseman D, Tummala M, Harmon C, Ryzhov V, Fineman J, Black SM. Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. DNA Cell Biol. 2010 Mar; 29(3):149-60. PMID: 20184449; PMCID: PMC2883531.
    65. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman J, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. PMID: 19830720; PMCID: PMC4427345.
    66. Shah A, Feraco AM, Harmon C, Tacy T, Fineman J, Bernstein HS. Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology. Am J Cardiol. 2009 Nov 01; 104(9):1280-4. PMID: 19840577; PMCID: PMC2791782.
    67. Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman J, She JX, Black SM. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics. 2009 Dec 30; 40(1):48-60. PMID: 19825830; PMCID: PMC2807211.
    68. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman J, Black SM. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64. PMID: 19818875; PMCID: PMC2879580.
    69. Natarajan S, Heiss C, Yeghiazarians Y, Fineman J, Teitel DF, Tacy TA. Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia. Am J Cardiol. 2009 Mar 15; 103(6):862-6. PMID: 19268746.
      View in: PubMed
    70. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman J, Black SM. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L756-66. PMID: 18757524; PMCID: PMC2584884.
    71. Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman J. Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection. J Thorac Cardiovasc Surg. 2008 Apr; 135(4):746-53. PMID: 18374751.
      View in: PubMed
    72. Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman J, Black SM. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L46-56. PMID: 18024721; PMCID: PMC3970936.
    73. Oishi P, Sharma S, Grobe A, Azakie A, Harmon C, Johengen MJ, Hsu JH, Fratz S, Black SM, Fineman J. Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs. Pediatr Pulmonol. 2007 Nov; 42(11):1057-71. PMID: 17902145.
      View in: PubMed
    74. Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman J. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. J Thorac Cardiovasc Surg. 2007 Nov; 134(5):1179-87. PMID: 17976447.
      View in: PubMed
    75. Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman J. B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):939-45. PMID: 17903511.
      View in: PubMed
    76. Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman J, Black SM. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol. 2007 Dec; 293(6):L1444-53. PMID: 17827253.
      View in: PubMed
    77. Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman J, Black SM. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L960-71. PMID: 17631609.
      View in: PubMed
    78. Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman J. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1491-7. PMID: 17513498; PMCID: PMC2111047.
    79. Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman J. Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide. Clin Hemorheol Microcirc. 2007; 37(1-2):111-20. PMID: 17641401.
      View in: PubMed
    80. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman J, Black SM. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res. 2007 Jan; 61(1):32-6. PMID: 17211137.
      View in: PubMed
    81. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman J. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94. PMID: 17006391.
      View in: PubMed
    82. Azakie A, Fineman J, He Y. Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo. J Thorac Cardiovasc Surg. 2006 Dec; 132(6):1262-71. PMID: 17140938.
      View in: PubMed
    83. Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman J, Chatterjee K, Michaels AD. Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension. J Card Fail. 2006 Sep; 12(7):507-13. PMID: 16952783.
      View in: PubMed
    84. Black SM, Fineman J. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vascul Pharmacol. 2006 Nov; 45(5):308-16. PMID: 17049313.
      View in: PubMed
    85. Oishi PE, Fineman J. BNP for pediatrics--not quite ready for primetime. Pediatr Crit Care Med. 2006 Jul; 7(4):388-9. PMID: 16829829.
      View in: PubMed
    86. Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman J, Black SM. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1069-77. PMID: 16684951.
      View in: PubMed
    87. Azakie A, Fineman J, He Y. Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H600-11. PMID: 16617124.
      View in: PubMed
    88. Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman J. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8. PMID: 16515916.
      View in: PubMed
    89. Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman J. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1922-32. PMID: 16339822.
      View in: PubMed
    90. Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman J. Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L359-66. PMID: 16258003.
      View in: PubMed
    91. Azakie A, Lamont L, Fineman J, He Y. Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1522-34. PMID: 16049055.
      View in: PubMed
    92. Beghetti M, Black SM, Fineman J. Endothelin-1 in congenital heart disease. Pediatr Res. 2005 May; 57(5 Pt 2):16R-20R. PMID: 15817494.
      View in: PubMed
    93. Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman J, Gutierrez JA. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L950-7. PMID: 15640287.
      View in: PubMed
    94. Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman J. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med. 2004 Nov; 5(6):571-7. PMID: 15530195.
      View in: PubMed
    95. Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman J. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L27-35. PMID: 15347565.
      View in: PubMed
    96. Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman J. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L592-7. PMID: 15155268.
      View in: PubMed
    97. Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman J. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med. 2004 May; 5(3):234-9. PMID: 15115560.
      View in: PubMed
    98. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. Ann Thorac Surg. 2004 May; 77(5):1727-33. PMID: 15111174.
      View in: PubMed
    99. Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman J. Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs. J Thorac Cardiovasc Surg. 2004 May; 127(5):1285-92. PMID: 15115984.
      View in: PubMed
    100. Keller RL, Hamrick SE, Kitterman JA, Fineman J, Hawgood S. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7. PMID: 14987351.
      View in: PubMed
    101. Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman J, Gutierrez JA. Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1237-43. PMID: 14751849.
      View in: PubMed
    102. Oishi P, Fineman J. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatr Crit Care Med. 2004 Jan; 5(1):94-6. PMID: 14709984.
      View in: PubMed
    103. Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman J. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation. 2003 Sep 30; 108(13):1646-54. PMID: 12963646.
      View in: PubMed
    104. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman J, Gutierrez JA. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L628-33. PMID: 12765879.
      View in: PubMed
    105. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman J, Black SM. Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L222-31. PMID: 12665467.
      View in: PubMed
    106. Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman J, Black SM. Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L209-21. PMID: 12665463.
      View in: PubMed
    107. Wedgwood S, Mitchell CJ, Fineman J, Black SM. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L650-62. PMID: 12533439.
      View in: PubMed
    108. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman J. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H480-90. PMID: 12399254.
      View in: PubMed
    109. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman J. Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. Am J Physiol Lung Cell Mol Physiol. 2002 Dec; 283(6):L1210-9. PMID: 12388350.
      View in: PubMed
    110. Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman J. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res. 2002 Aug; 52(2):233-44. PMID: 12149501.
      View in: PubMed
    111. Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman J. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H862-71. PMID: 11834480.
      View in: PubMed