Giorgio Lagna, PhD

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #212
San Francisco CA 94158
Phone415-476-9759
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    Collapse Biography 
    Collapse Education and Training
    The Rockefeller UniversityPostdoctoral Training2000
    University of Rome "La Sapienza"PhD1997

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease. JCI Insight. 2024 Sep 05; 9(19). Prabhakar A, Wadhwa M, Kumar R, Ghatpande P, Gandjeva A, Tuder RM, Graham BB, Lagna G, Hata A. PMID: 39269983; PMCID: PMC11466196.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response. Nat Cardiovasc Res. 2024 Jul; 3(7):799-818. Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A. PMID: 39196173; PMCID: PMC11409862.
      View in: PubMed   Mentions: 1  Translation:HumansAnimalsCells
    3. Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response. bioRxiv. 2023 Nov 28. Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A. PMID: 38076809; PMCID: PMC10705277.
      View in: PubMed   Mentions:
    4. Essential role of the amino-terminal region of Drosha for the Microprocessor function. iScience. 2023 Oct 20; 26(10):107971. Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A. PMID: 37810246; PMCID: PMC10558778.
      View in: PubMed   Mentions:
    5. How do you mend inactive tumor suppressor mutants? You glue them! Cell Chem Biol. 2021 05 20; 28(5):585-587. Hata A, Lagna G. PMID: 34019843.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Control of ribosomal protein synthesis by the Microprocessor complex. Sci Signal. 2021 02 23; 14(671). Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. PMID: 33622983; PMCID: PMC8012103.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia. Curr Opin Hematol. 2019 05; 26(3):161-169. Hata A, Lagna G. PMID: 30855334; PMCID: PMC6476316.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells. Commun Biol. 2018; 1:149. Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A. PMID: 30272025; PMCID: PMC6155317.
      View in: PubMed   Mentions: 10  
    9. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 01 16; 11(513). Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. PMID: 29339534; PMCID: PMC5811261.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017 07 25; 8(1):128. Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A. PMID: 28743859; PMCID: PMC5527007.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci Signal. 2017 May 02; 10(477). Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. PMID: 28465421; PMCID: PMC5557344.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    12. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. PMID: 27273096; PMCID: PMC5274719.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    13. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J. 2013 Dec 11; 32(24):3192-205. Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A. PMID: 24219989; PMCID: PMC3981142.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    14. Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J Biol Chem. 2012 Nov 09; 287(46):38656-64. Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A. PMID: 22988237; PMCID: PMC3493910.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    15. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012 Aug 10; 287(33):28067-77. Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G. PMID: 22718766; PMCID: PMC3431673.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    16. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. PMID: 22158624; PMCID: PMC3281737.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    17. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. PMID: 21969601; PMCID: PMC3232924.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    18. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. PMID: 21673106; PMCID: PMC3151055.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    19. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb; 31(3):517-30. Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. PMID: 21135135; PMCID: PMC3028626.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell. 2010 Aug 13; 39(3):373-84. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. PMID: 20705240; PMCID: PMC2921543.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    21. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. PMID: 20019669; PMCID: PMC2830697.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    22. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem. 2009 May 08; 284(19):13202-12. Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. PMID: 19265191; PMCID: PMC2676052.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    23. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009 Feb 06; 284(6):3728-38. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. PMID: 19088079; PMCID: PMC2635044.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansCells
    24. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008 Jul 03; 454(7200):56-61. Davis BN, Hilyard AC, Lagna G, Hata A. PMID: 18548003; PMCID: PMC2653422.
      View in: PubMed   Mentions: 720     Fields:    Translation:HumansAnimalsCells
    25. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem. 2007 Dec 21; 282(51):37244-55. Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. PMID: 17947237; PMCID: PMC3405982.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    26. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 2007 Aug; 27(16):5776-89. Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. PMID: 17576816; PMCID: PMC1952124.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    27. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1059-67. Lagna G, Nguyen PH, Ni W, Hata A. PMID: 17030903.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    28. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006 Feb 24; 281(8):5277-87. Ku M, Howard S, Ni W, Lagna G, Hata A. PMID: 16373339.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    29. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell. 2000 Jan 21; 100(2):229-40. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J. PMID: 10660046.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    30. A molecular basis for Smad specificity. Dev Dyn. 1999 Mar; 214(3):269-77. Lagna G, Hemmati-Brivanlou A. PMID: 10090153.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Negative regulation of axis formation and Wnt signaling in Xenopus embryos by the F-box/WD40 protein beta TrCP. Mech Dev. 1999 Jan; 80(1):101-6. Lagna G, Carnevali F, Marchioni M, Hemmati-Brivanlou A. PMID: 10096067.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    32. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998 Jan 15; 12(2):186-97. Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. PMID: 9436979; PMCID: PMC316444.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    33. Use of dominant negative constructs to modulate gene expression. Curr Top Dev Biol. 1998; 36:75-98. Lagna G, Hemmati-Brivanlou A. PMID: 9342522.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development. 1997 Aug; 124(16):3177-84. Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A. PMID: 9272958.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    35. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature. 1997 Jul 03; 388(6637):82-7. Hata A, Lo RS, Wotton D, Lagna G, Massagué J. PMID: 9214507.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    36. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature. 1996 Oct 31; 383(6603):832-6. Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J. PMID: 8893010.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    37. Overlapping transcription by RNA polymerases II and III of the Xenopus TFIIIA gene in somatic cells. J Biol Chem. 1994 Oct 14; 269(41):25692-8. Martinez E, Lagna G, Roeder RG. PMID: 7929274.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC. Mol Cell Biol. 1994 May; 14(5):3053-64. Lagna G, Kovelman R, Sukegawa J, Roeder RG. PMID: 8164661; PMCID: PMC358673.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. HrpF, a human sequence-specific DNA-binding protein homologous to XrpFI, a Xenopus laevis oocyte transcription factor. Nucleic Acids Res. 1990 Oct 11; 18(19):5811-6. Lagna G, Loreni F, Beccari E, Carnevali F. PMID: 2216772; PMCID: PMC332319.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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