Akiko Hata, PhD

InstitutionUniversity of California San Francisco
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    The Rockefeller UniversityPhD1995
    Memorial Sloan-Kettering Cancer CenterPost-doc2000

    Collapse Research 
    Collapse Research Activities and Funding
    Role of DNA damage in Pulmonary Artery Hypertension
    TRDRP 587294Jul 1, 2018 - Jun 30, 2021
    Role: Principle Investigator
    FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease
    NIH/NCI R13CA217045Jul 1, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Identification of a novel modulator of Pulmonary Artery Hypertension
    NIH/NHLBI R01HL132058Jun 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease
    NIH/NCI R13CA196044May 20, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Role of the PDGF signaling pathway in pulmonary artery hypertension
    NIH/NHLBI R01HL116191Aug 15, 2013 - May 31, 2017
    Role: Principal Investigator
    Role of miRNAs in Vascular Physiology
    NIH/NHLBI R01HL093154Jun 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension
    NIH/NHLBI R01HL082854Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Mechanisms of TGFB Signal Transduction
    NIH/NICHD R01HD042149Jul 7, 2003 - May 31, 2010
    Role: Principal Investigator
    Mechanisms of TGFB Signal Transduction
    NIH/NHLBI R01HL108317Apr 1, 2002 - Mar 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A. Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells. Commun Biol. 2018; 1:149. PMID: 30272025.
      View in: PubMed
    2. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme J, Hata A, Fineman JR. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. Am J Physiol Heart Circ Physiol. 2018 Jun 15. PMID: 29906222.
      View in: PubMed
    3. Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 Jan 16; 11(513). PMID: 29339534.
      View in: PubMed
    4. Kashima R, Hata A. The role of TGF-ß superfamily signaling in neurological disorders. Acta Biochim Biophys Sin (Shanghai). 2018 Jan 01; 50(1):106-120. PMID: 29190314.
      View in: PubMed
    5. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19; 136(25):2451-2467. PMID: 28971999.
      View in: PubMed
    6. Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017 07 25; 8(1):128. PMID: 28743859.
      View in: PubMed
    7. Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci Signal. 2017 May 02; 10(477). PMID: 28465421.
      View in: PubMed
    8. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 Jan 10; 6. PMID: 28072389.
      View in: PubMed
    9. Hata A, Chen YG. TGF-ß Signaling from Receptors to Smads. Cold Spring Harb Perspect Biol. 2016 Sep 01; 8(9). PMID: 27449815.
      View in: PubMed
    10. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. PMID: 27273096.
      View in: PubMed
    11. Kang H, Hata A. Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-ß Signaling. Methods Mol Biol. 2016; 1344:313-23. PMID: 26520134.
      View in: PubMed
    12. Hata A, Kashima R. Dysregulation of microRNA biogenesis machinery in cancer. Crit Rev Biochem Mol Biol. 2016 May-Jun; 51(3):121-34. PMID: 26628006.
      View in: PubMed
    13. Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD. Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol. 2016 Feb; 13(2):106-20. PMID: 26461965.
      View in: PubMed
    14. Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A. Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease. Circ J. 2015; 79(9):2043-9. PMID: 26062950.
      View in: PubMed
    15. Kang H, Hata A. The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis. BMB Rep. 2015 Jun; 48(6):319-23. PMID: 25341923; PMCID: PMC4578617.
    16. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015 May; 11(5):e1005238. PMID: 26020233; PMCID: PMC4447351.
    17. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. PMID: 25783160.
      View in: PubMed
    18. Hata A, Kang H. Functions of the bone morphogenetic protein signaling pathway through microRNAs (review). Int J Mol Med. 2015 Mar; 35(3):563-8. PMID: 25571950.
      View in: PubMed
    19. Kim S, Hata A, Kang H. Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation. J Cell Biochem. 2014 May; 115(5):889-95. PMID: 24375867.
      View in: PubMed
    20. Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ. Cardiovascular applications of therapeutic ultrasound. J Interv Card Electrophysiol. 2014 Apr; 39(3):287-94. PMID: 24297498.
      View in: PubMed
    21. Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J. 2013 Dec 11; 32(24):3192-205. PMID: 24219989; PMCID: PMC3981142.
    22. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82. PMID: 23867623; PMCID: PMC3726159.
    23. Sessa R, Hata A. Role of microRNAs in lung development and pulmonary diseases. Pulm Circ. 2013 Apr; 3(2):315-28. PMID: 24015331; PMCID: PMC3757825.
    24. Blahna MT, Hata A. Regulation of miRNA biogenesis as an integrated component of growth factor signaling. Curr Opin Cell Biol. 2013 Apr; 25(2):233-40. PMID: 23312066; PMCID: PMC4429755.
    25. Hata A. Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol. 2013; 75:69-93. PMID: 23157557.
      View in: PubMed
    26. Akhurst RJ, Hata A. Targeting the TGFß signalling pathway in disease. Nat Rev Drug Discov. 2012 Oct; 11(10):790-811. PMID: 23000686; PMCID: PMC3520610.
    27. Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A. Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J Biol Chem. 2012 Nov 09; 287(46):38656-64. PMID: 22988237; PMCID: PMC3493910.
    28. Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012 Aug 10; 287(33):28067-77. PMID: 22718766; PMCID: PMC3431673.
    29. Kang H, Hata A. MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol. 2012 May; 19(3):224-31. PMID: 22406821.
      View in: PubMed
    30. Hata A, Brivanlou AH. A taste of TGFß in Tuscany. Development. 2012 Feb; 139(3):449-53. PMID: 22223676.
      View in: PubMed
    31. Blahna MT, Hata A. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett. 2012 Jul 04; 586(14):1906-12. PMID: 22306316; PMCID: PMC4429768.
    32. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. PMID: 22158624; PMCID: PMC3281737.
    33. McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res. 2012 Mar 15; 93(4):594-604. PMID: 22065733; PMCID: PMC3410429.
    34. Davis-Dusenbery BN, Wu C, Hata A. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7. PMID: 22011749; PMCID: PMC4429757.
    35. Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. PMID: 21969601; PMCID: PMC3232924.
    36. Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. PMID: 21673106; PMCID: PMC3151055.
    37. Hata A, Davis BN. Regulation of pri-miRNA Processing Through Smads. Adv Exp Med Biol. 2011; 700:15-27. PMID: 21755469.
      View in: PubMed
    38. Davis-Dusenbery BN, Hata A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol. 2011 Jan-Feb; 8(1):71-6. PMID: 21289485; PMCID: PMC3230544.
    39. Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb; 31(3):517-30. PMID: 21135135; PMCID: PMC3028626.
    40. Davis-Dusenbery BN, Hata A. MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways. Genes Cancer. 2010 Nov; 1(11):1100-14. PMID: 21533017; PMCID: PMC3083114.
    41. Davis-Dusenbery BN, Hata A. Mechanisms of control of microRNA biogenesis. J Biochem. 2010 Oct; 148(4):381-92. PMID: 20833630; PMCID: PMC2981492.
    42. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell. 2010 Aug 13; 39(3):373-84. PMID: 20705240; PMCID: PMC2921543.
    43. Hata A, Davis BN. Regulation of pri-miRNA processing through Smads. Adv Exp Med Biol. 2010; 700:15-27. PMID: 21627026.
      View in: PubMed
    44. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. PMID: 20019669; PMCID: PMC2830697.
    45. Hata A, Davis BN. Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):517-21. PMID: 19892582; PMCID: PMC2787811.
    46. Davis BN, Hata A. Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal. 2009 Aug 10; 7:18. PMID: 19664273; PMCID: PMC3224893.
    47. Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 07; 15(4):328-40. PMID: 19345331; PMCID: PMC2693316.
    48. Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem. 2009 May 08; 284(19):13202-12. PMID: 19265191; PMCID: PMC2676052.
    49. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009 Feb 06; 284(6):3728-38. PMID: 19088079; PMCID: PMC2635044.
    50. Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008 Jul 03; 454(7200):56-61. PMID: 18548003; PMCID: PMC2653422.
    51. Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem. 2007 Dec 21; 282(51):37244-55. PMID: 17947237; PMCID: PMC3405982.
    52. Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 2007 Aug; 27(16):5776-89. PMID: 17576816; PMCID: PMC1952124.
    53. Lagna G, Nguyen PH, Ni W, Hata A. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1059-67. PMID: 17030903.
      View in: PubMed
    54. Ku M, Howard S, Ni W, Lagna G, Hata A. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006 Feb 24; 281(8):5277-87. PMID: 16373339.
      View in: PubMed
    55. Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol. 2005 Aug; 25(16):7144-57. PMID: 16055724; PMCID: PMC1190264.
    56. Seki K, Hata A. Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. J Biol Chem. 2004 Apr 30; 279(18):18544-9. PMID: 14981086.
      View in: PubMed
    57. Ku MC, Stewart S, Hata A. Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):702-7. PMID: 14623329.
      View in: PubMed
    58. Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood. 2004 Mar 15; 103(6):2062-70. PMID: 14630787.
      View in: PubMed
    59. Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L. Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem. 2003 Oct 24; 278(43):41862-70. PMID: 12917416; PMCID: PMC2253659.