Brian Malone, PhD

Title(s)Assistant Professor, Otolaryngology
SchoolSchool of Medicine
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    Brian Malone, PhD, is an Assistant Adjunct Professor in the Department of Otolaryngology - Head and Neck Surgery at the University of California, San Francisco. He specializes in the neurophysiology of the central auditory system, with a focus on the cortical representation of dynamic sounds. Dr. Malone's overall goal is to understand the fundamental neural coding principles that enable robust speech comprehension in challenging listening environments. By pursuing basic research on this issue, Dr. Malone hopes to use the knowledge gained to guide the development of novel therapeutic approaches to communicative disorders, such as algorithms for speech enhancement in hearing aids, and stimulation protocols for neural prosthetic devices for hearing.

    His laboratory employs multichannel electrophysiological recordings, computational models, and psychophysical approaches to answer fundamental questions about how auditory cortex processes complex sounds amid competing background noise. Much of his recent research has focused on the encoding of low frequency envelope information because such information is crucial for intelligible speech, and a chief goal for the laboratory is to develop a better general framework for understanding cortical envelope processing.

    Dr. Malone has been awarded funding from the National Institutes of Health for his predoctoral (NRSA), postdoctoral (NRSA), and current (R01) research at the John C. and Edward Coleman Memorial Laboratory of the Department.

    Sound encoding in the core fields of auditory cortex

    Computationally-driven neurophysiological characterization of how features of sounds are encoded and represented in the firing patterns of cortical neurons

    Professional Interests:
    Developing computational models of auditory receptive fields that capture nonlinear features of the cortical encoding model, and investigating how those features contribute to complex perceptual tasks such as auditory scene segmentation, speech comprehension, and timbral discrimination

    Education and Training:
    • Doctoral: New York University - Neural Sciences
    • Postdoctoral: David Geffen School of Medicine at UCLA - Image processing in primary visual cortex

    Collapse Research 
    Collapse Research Activities and Funding
    Nonlinear dynamics of complex sound processing in auditory cortex
    NIH/NIDCD R01DC011843Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Characterizing the Neural Basis of Image Interpolation
    NIH/NEI F32EY015365Sep 30, 2003 - Sep 29, 2006
    Role: Principal Investigator
    NIH/NIMH F31MH012293Jan 11, 1999
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hoglen NEG, Larimer P, Phillips EAK, Malone BJ, Hasenstaub AR. Amplitude modulation coding in awake mice and squirrel monkeys. J Neurophysiol. 2018 05 01; 119(5):1753-1766. PMID: 29364073.
      View in: PubMed
    2. Bigelow J, Malone BJ. Cluster-based analysis improves predictive validity of spike-triggered receptive field estimates. PLoS One. 2017; 12(9):e0183914. PMID: 28877194.
      View in: PubMed
    3. Malone BJ, Heiser MA, Beitel RE, Schreiner CE. Background noise exerts diverse effects on the cortical encoding of foreground sounds. J Neurophysiol. 2017 Aug 01; 118(2):1034-1054. PMID: 28490644.
      View in: PubMed
    4. Teschner MJ, Seybold BA, Malone BJ, Hüning J, Schreiner CE. Effects of Signal-to-Noise Ratio on Auditory Cortical Frequency Processing. J Neurosci. 2016 Mar 02; 36(9):2743-56. PMID: 26937012; PMCID: PMC4879216.
    5. Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE. Modulation-frequency-specific adaptation in awake auditory cortex. J Neurosci. 2015 Apr 15; 35(15):5904-16. PMID: 25878263; PMCID: PMC4397592.
    6. Malone BJ, Scott BH, Semple MN. Diverse cortical codes for scene segmentation in primate auditory cortex. J Neurophysiol. 2015 Apr 01; 113(7):2934-52. PMID: 25695655.
      View in: PubMed
    7. Schreiner CE, Malone BJ. Representation of loudness in the auditory cortex. Handb Clin Neurol. 2015; 129:73-84. PMID: 25726263.
      View in: PubMed
    8. Malone BJ, Scott BH, Semple MN. Encoding frequency contrast in primate auditory cortex. J Neurophysiol. 2014 Jun 01; 111(11):2244-63. PMID: 24598525; PMCID: PMC4097870.
    9. Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE. Spectral context affects temporal processing in awake auditory cortex. J Neurosci. 2013 May 29; 33(22):9431-50. PMID: 23719811; PMCID: PMC3829847.
    10. Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 01; 304(11):G1002-12. PMID: 23558009; PMCID: PMC3680686.
    11. Scott BH, Malone BJ, Semple MN. Transformation of temporal processing across auditory cortex of awake macaques. J Neurophysiol. 2011 Feb; 105(2):712-30. PMID: 21106896.
      View in: PubMed
    12. Malone BJ, Scott BH, Semple MN. Temporal codes for amplitude contrast in auditory cortex. J Neurosci. 2010 Jan 13; 30(2):767-84. PMID: 20071542.
      View in: PubMed
    13. Scott BH, Malone BJ, Semple MN. Representation of dynamic interaural phase difference in auditory cortex of awake rhesus macaques. J Neurophysiol. 2009 Apr; 101(4):1781-99. PMID: 19164111.
      View in: PubMed
    14. Malone BJ, Ringach DL. Dynamics of tuning in the Fourier domain. J Neurophysiol. 2008 Jul; 100(1):239-48. PMID: 18480369; PMCID: PMC2493484.
    15. Ringach DL, Malone BJ. The operating point of the cortex: neurons as large deviation detectors. J Neurosci. 2007 Jul 18; 27(29):7673-83. PMID: 17634362.
      View in: PubMed
    16. Malone BJ, Scott BH, Semple MN. Dynamic amplitude coding in the auditory cortex of awake rhesus macaques. J Neurophysiol. 2007 Sep; 98(3):1451-74. PMID: 17615123.
      View in: PubMed
    17. Scott BH, Malone BJ, Semple MN. Effect of behavioral context on representation of a spatial cue in core auditory cortex of awake macaques. J Neurosci. 2007 Jun 13; 27(24):6489-99. PMID: 17567810.
      View in: PubMed
    18. Malone BJ, Kumar VR, Ringach DL. Dynamics of receptive field size in primary visual cortex. J Neurophysiol. 2007 Jan; 97(1):407-14. PMID: 17021020.
      View in: PubMed
    19. Malone BJ, Scott BH, Semple MN. Context-dependent adaptive coding of interaural phase disparity in the auditory cortex of awake macaques. J Neurosci. 2002 Jun 01; 22(11):4625-38. PMID: 12040069.
      View in: PubMed
    20. Malone BJ, Semple MN. Effects of auditory stimulus context on the representation of frequency in the gerbil inferior colliculus. J Neurophysiol. 2001 Sep; 86(3):1113-30. PMID: 11535662.
      View in: PubMed
    21. Sanes DH, Malone BJ, Semple MN. Role of synaptic inhibition in processing of dynamic binaural level stimuli. J Neurosci. 1998 Jan 15; 18(2):794-803. PMID: 9425020.
      View in: PubMed