Brian Malone, PhD

Title(s)Associate Professor, Otolaryngology
SchoolSchool of Medicine
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    Brian Malone, PhD, is an Associate Adjunct Professor in the Department of Otolaryngology - Head and Neck Surgery at the University of California, San Francisco. He specializes in the neurophysiology of the central auditory system, with a focus on the cortical representation of dynamic sounds. Dr. Malone's overall goal is to understand the fundamental neural coding principles that enable robust speech comprehension in challenging listening environments. By pursuing basic research on this issue, Dr. Malone hopes to use the knowledge gained to guide the development of novel therapeutic approaches to communicative disorders, such as algorithms for speech enhancement in hearing aids, and stimulation protocols for neural prosthetic devices for hearing.

    His laboratory employs multichannel electrophysiological recordings, computational models, and psychophysical approaches to answer fundamental questions about how auditory cortex processes complex sounds amid competing background noise. Much of his recent research has focused on the encoding of low frequency envelope information because such information is crucial for intelligible speech, and a chief goal for the laboratory is to develop a better general framework for understanding cortical envelope processing.

    Dr. Malone has been awarded funding from the National Institutes of Health for his predoctoral (NRSA), postdoctoral (NRSA), and current (R01) research at the John C. and Edward Coleman Memorial Laboratory of the Department.

    Sound encoding in the core fields of auditory cortex

    Computationally-driven neurophysiological characterization of how features of sounds are encoded and represented in the firing patterns of cortical neurons

    Professional Interests:
    Developing computational models of auditory receptive fields that capture nonlinear features of the cortical encoding model, and investigating how those features contribute to complex perceptual tasks such as auditory scene segmentation, speech comprehension, and timbral discrimination

    Education and Training:
    • Doctoral: New York University - Neural Sciences
    • Postdoctoral: David Geffen School of Medicine at UCLA - Image processing in primary visual cortex

    Collapse Research 
    Collapse Research Activities and Funding
    Effects of aging on signal in noise processing
    NIH R01AG067791Feb 1, 2021 - Dec 31, 2025
    Role: Co-Principal Investigator
    Effects of aging on signal in noise processing
    NIH R56AG067791Sep 30, 2020 - Aug 31, 2021
    Role: Co-Principal Investigator
    Nonlinear dynamics of complex sound processing in auditory cortex
    NIH R01DC011843Apr 1, 2012 - Mar 31, 2018
    Role: Principal Investigator
    Characterizing the Neural Basis of Image Interpolation
    NIH F32EY015365Sep 30, 2003 - Sep 29, 2006
    Role: Principal Investigator
    NIH F31MH012293Jan 11, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Temporally precise population coding of dynamic sounds by auditory cortex. J Neurophysiol. 2021 07 01; 126(1):148-169. Downer JD, Bigelow J, Runfeldt MJ, Malone BJ. PMID: 34077273; PMCID: PMC8325602.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    2. Extracellular voltage thresholds for maximizing information extraction in primate auditory cortex: implications for a brain computer interface. J Neural Eng. 2021 03 04; 18(3). Bigelow J, Malone BJ. PMID: 32126540.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    3. Amplitude modulation coding in awake mice and squirrel monkeys. J Neurophysiol. 2018 05 01; 119(5):1753-1766. Hoglen NEG, Larimer P, Phillips EAK, Malone BJ, Hasenstaub AR. PMID: 29364073; PMCID: PMC6008086.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    4. Cluster-based analysis improves predictive validity of spike-triggered receptive field estimates. PLoS One. 2017; 12(9):e0183914. Bigelow J, Malone BJ. PMID: 28877194; PMCID: PMC5587334.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Background noise exerts diverse effects on the cortical encoding of foreground sounds. J Neurophysiol. 2017 08 01; 118(2):1034-1054. Malone BJ, Heiser MA, Beitel RE, Schreiner CE. PMID: 28490644; PMCID: PMC5547268.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    6. Effects of Signal-to-Noise Ratio on Auditory Cortical Frequency Processing. J Neurosci. 2016 Mar 02; 36(9):2743-56. Teschner MJ, Seybold BA, Malone BJ, Hüning J, Schreiner CE. PMID: 26937012; PMCID: PMC4879216.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    7. Modulation-frequency-specific adaptation in awake auditory cortex. J Neurosci. 2015 Apr 15; 35(15):5904-16. Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE. PMID: 25878263; PMCID: PMC4397592.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    8. Diverse cortical codes for scene segmentation in primate auditory cortex. J Neurophysiol. 2015 Apr 01; 113(7):2934-52. Malone BJ, Scott BH, Semple MN. PMID: 25695655; PMCID: PMC4416616.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Representation of loudness in the auditory cortex. Handb Clin Neurol. 2015; 129:73-84. Schreiner CE, Malone BJ. PMID: 25726263.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    10. Encoding frequency contrast in primate auditory cortex. J Neurophysiol. 2014 Jun 01; 111(11):2244-63. Malone BJ, Scott BH, Semple MN. PMID: 24598525; PMCID: PMC4097870.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Spectral context affects temporal processing in awake auditory cortex. J Neurosci. 2013 May 29; 33(22):9431-50. Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE. PMID: 23719811; PMCID: PMC3829847.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    12. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 01; 304(11):G1002-12. Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS. PMID: 23558009; PMCID: PMC3680686.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    13. Transformation of temporal processing across auditory cortex of awake macaques. J Neurophysiol. 2011 Feb; 105(2):712-30. Scott BH, Malone BJ, Semple MN. PMID: 21106896; PMCID: PMC3059172.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    14. Temporal codes for amplitude contrast in auditory cortex. J Neurosci. 2010 Jan 13; 30(2):767-84. Malone BJ, Scott BH, Semple MN. PMID: 20071542; PMCID: PMC3551278.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    15. Representation of dynamic interaural phase difference in auditory cortex of awake rhesus macaques. J Neurophysiol. 2009 Apr; 101(4):1781-99. Scott BH, Malone BJ, Semple MN. PMID: 19164111; PMCID: PMC2695633.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Dynamics of tuning in the Fourier domain. J Neurophysiol. 2008 Jul; 100(1):239-48. Malone BJ, Ringach DL. PMID: 18480369; PMCID: PMC2493484.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    17. The operating point of the cortex: neurons as large deviation detectors. J Neurosci. 2007 Jul 18; 27(29):7673-83. Ringach DL, Malone BJ. PMID: 17634362; PMCID: PMC6672889.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    18. Dynamic amplitude coding in the auditory cortex of awake rhesus macaques. J Neurophysiol. 2007 Sep; 98(3):1451-74. Malone BJ, Scott BH, Semple MN. PMID: 17615123.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    19. Effect of behavioral context on representation of a spatial cue in core auditory cortex of awake macaques. J Neurosci. 2007 Jun 13; 27(24):6489-99. Scott BH, Malone BJ, Semple MN. PMID: 17567810; PMCID: PMC6672434.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    20. Dynamics of receptive field size in primary visual cortex. J Neurophysiol. 2007 Jan; 97(1):407-14. Malone BJ, Kumar VR, Ringach DL. PMID: 17021020.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    21. Context-dependent adaptive coding of interaural phase disparity in the auditory cortex of awake macaques. J Neurosci. 2002 Jun 01; 22(11):4625-38. Malone BJ, Scott BH, Semple MN. PMID: 12040069; PMCID: PMC6758792.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    22. Effects of auditory stimulus context on the representation of frequency in the gerbil inferior colliculus. J Neurophysiol. 2001 Sep; 86(3):1113-30. Malone BJ, Semple MN. PMID: 11535662.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    23. Role of synaptic inhibition in processing of dynamic binaural level stimuli. J Neurosci. 1998 Jan 15; 18(2):794-803. Sanes DH, Malone BJ, Semple MN. PMID: 9425020; PMCID: PMC6792525.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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