Kimberly Kirkwood, MD

Title(s)Professor, Surgery
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Reed CollegeB.A.1981
    University of PennsylvaniaM.D.1985School of Medicine
    Massachusetts General HospitalResidency in General Surgery1993Department of Surgery
    UCLAPancreas/GI Research Fellowship1991Department of Surgery
    Massachusetts General HospitalClinical Instructor/Pancreas Fellow1994Department of Surgery
    Massachusetts General HospitalPancreas/Advanced General Surgery Fellowship1994Department of Surgery
    UCSFGeneral Surgery Board Certification2004Department of Surgery
    UCSFGeneral Surgery Board Certification2014Department of Surgery
    Collapse Awards and Honors
    Phi Beta Kappa National Honor Society1981Phi Beta Kappa National Honor Society
    University of Pennsylvania Chapter1983President, Alpha Omega Alpha National Medical Honor Society
    UCSF School of Medicine1997Kaiser Award for Excellence in Teaching Nomination
    UCSF Department of Surgery Residents2001Excellence in Teaching Award
    UCSF Department of Surgery Chief Residents2008  - 2009Excellence in Teaching Award
    Pancreas Club2010Pancreas Club Warren Award (Victoria Lyo),
    Inaugural, UCSF Department of Surgery Junior Residents2015Excellence in Teaching Award
    University of Pennsylvania School of Medicine1981Walter Croll Scholarship
    Department of Surgery, Massachusetts General Hospita1989  - 1990Claude E. Welch Research Fellowship Award
    UCSF School of Medicine1999 Kaiser Award for Excellence in Teaching Nomination
    UCSF Department of Surgery Chief Residents2004Excellence in Teaching Award
    UCSF School of Medicine2004Kaiser Award for Excellence in Teaching Nomination
    UCSF Department of Surgery Chief Residents2008  - 2009Excellence in Teaching Award
    American Gastroenterological Association (AGA) Foundation2010AGA Student Abstract Prize (Victoria Lyo),
    UCSF School of Medicine2010Kaiser Award for Excellence in Teaching Nomination
    Howard Hughes Medical Institute2010Howard Hughes Research Fellowship (Victoria Lyo),
    Howard Hughes Medical Institute2010Howard Hughes Research Fellowship (Victoria Lyo),
    UCSF Department of Surgery Chief Residents2012Excellence in Teaching Award
    UCSF School of Medicine, Surgical Clerkship2013Excellence in Teaching Award
    UCSF Department of Surgery Chief Residents2014Excellence in Teaching Award

    Collapse Research 
    Collapse Research Activities and Funding
    Minimally Invasive Classification of Pancreatic Cystic Neoplasms
    V Foundation T2017-013Nov 1, 2017 - Nov 1, 2020
    Role: Principal Investigator
    Role Description: Our goal is to develop new tools to differentiate low risk from high risk lesions among patients with pancreatic cysts
    Development of fluorogenic substrates for the diagnosis of pancreatic cysts
    UCSF Clinical and Translational Sciences Institute Catalyst Awards ProgramFeb 1, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Molecular Correlates of progression in pancreatic cystic neoplasms
    NCI/NIH U01Jul 1, 2015 - Jun 30, 2021
    Role: Site Principal Investigator, UCSF
    Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer
    NIH/NCI R21CA185689Jan 1, 2015 - Dec 31, 2016
    Role: Co-Principal Investigator
    Neural Regulation of Pancreatic Function
    NIH/NIDDK R01DK046285May 15, 1994 - Mar 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biol Chem. 2019 Jul 01. PMID: 31256057.
      View in: PubMed
    2. Kim SS, Ko AH, Nakakura EK, Wang ZJ, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Kim GE. Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization? Am J Surg Pathol. 2019 Mar; 43(3):334-340. PMID: 30211728.
      View in: PubMed
    3. Changala M, Laberge J, Kerlan R, Taylor A, Arain M, Kirkwood K. Managing Refractory Postoperative Fistulas as Chronic Wounds Using Video-Assisted Hydrodebridement (VAHD). J Gastrointest Surg. 2019 Mar; 23(3):608-612. PMID: 30465188.
      View in: PubMed
    4. Sharib JM, Fonseca AL, Swords DS, Jaradeh K, Bracci PM, Firpo MA, Hatcher S, Scaife CL, Wang H, Kim GE, Mulvihill SJ, Maitra A, Koay EJ, Kirkwood KS. Surgical overtreatment of pancreatic intraductal papillary mucinous neoplasms: Do the 2017 International Consensus Guidelines improve clinical decision making? Surgery. 2018 Dec; 164(6):1178-1184. PMID: 30170819.
      View in: PubMed
    5. Fonseca AL, Kirkwood K, Kim MP, Maitra A, Koay EJ. Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk. Pancreas. 2018 03; 47(3):272-279. PMID: 29424809.
      View in: PubMed
    6. Kirkwood R, Damon L, Wang J, Hong E, Kirkwood K. Gangrenous cholecystitis: innovative laparoscopic techniques to facilitate subtotal fenestrating cholecystectomy when a critical view of safety cannot be achieved. Surg Endosc. 2017 12; 31(12):5258-5266. PMID: 28597281.
      View in: PubMed
    7. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. PMID: 28424202.
      View in: PubMed
    8. Sharib J, Kirkwood K. Early and accurate diagnosis of pancreatic cancer? Oncotarget. 2016 12 27; 7(52):85676-85677. PMID: 27829239.
      View in: PubMed
    9. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596. PMID: 27444658.
      View in: PubMed
    10. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett. 2015 Jan 28; 356(2 Pt B):404-9. PMID: 25304377.
      View in: PubMed
    11. Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW. Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants. Br J Pharmacol. 2014 Aug; 171(16):3814-26. PMID: 24749982; PMCID: PMC4128045.
    12. Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 01; 304(11):G1002-12. PMID: 23558009; PMCID: PMC3680686.
    13. Lee Char SJ, Hills NK, Lo B, Kirkwood KS. Informed consent for innovative surgery: a survey of patients and surgeons. Surgery. 2013 Apr; 153(4):473-80. PMID: 23218878; PMCID: PMC3602241.
    14. Lyo V, Cattaruzza F, Kim TN, Walker AW, Paulick M, Cox D, Cloyd J, Buxbaum J, Ostroff J, Bogyo M, Grady EF, Bunnett NW, Kirkwood KS. Active cathepsins B, L, and S in murine and human pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15; 303(8):G894-903. PMID: 22899821; PMCID: PMC3469694.
    15. Minter RM, Angelos P, Coimbra R, Dale P, de Vera ME, Hardacre J, Hawkins W, Kirkwood K, Matthews JB, McLoughlin J, Peralta E, Schmidt M, Zhou W, Schwarze ML. Ethical management of conflict of interest: proposed standards for academic surgical societies. J Am Coll Surg. 2011 Nov; 213(5):677-82. PMID: 21880513.
      View in: PubMed
    16. Ceppa EP, Lyo V, Grady EF, Knecht W, Grahn S, Peterson A, Bunnett NW, Kirkwood KS, Cattaruzza F. Serine proteases mediate inflammatory pain in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G1033-42. PMID: 21436316; PMCID: PMC3774216.
    17. Ceppa E, Cattaruzza F, Lyo V, Amadesi S, Pelayo JC, Poole DP, Vaksman N, Liedtke W, Cohen DM, Grady EF, Bunnett NW, Kirkwood KS. Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G556-71. PMID: 20539005; PMCID: PMC2950679.
    18. Maa J, Carter JT, Kirkwood KS, Gosnell JE, Wang V, McDermott MW. Technique for placement of lumboperitoneal catheters using a combined laparoscopic procedure with the Seldinger micropuncture technique. J Am Coll Surg. 2008 Jul; 207(1):e5-7. PMID: 18589351.
      View in: PubMed
    19. Finzi L, Barbu V, Burgel PR, Mergey M, Kirkwood KS, Wick EC, Scoazec JY, Peschaud F, Paye F, Nadel JA, Housset C. MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder. Am J Pathol. 2006 Dec; 169(6):2031-41. PMID: 17148666; PMCID: PMC1762466.
    20. Grahn SW, Alvarez J, Kirkwood K. Trends in laparoscopic splenectomy for massive splenomegaly. Arch Surg. 2006 Aug; 141(8):755-61; discussion 761-2. PMID: 16924082.
      View in: PubMed
    21. Wick EC, Pikios S, Grady EF, Kirkwood KS. Calcitonin gene-related peptide partially mediates nociception in acute experimental pancreatitis. Surgery. 2006 Feb; 139(2):197-201. PMID: 16455328.
      View in: PubMed
    22. Wick EC, Hoge SG, Grahn SW, Kim E, Divino LA, Grady EF, Bunnett NW, Kirkwood KS. Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G959-69. PMID: 16399878.
      View in: PubMed
    23. Day AL, Wick E, Jordan TH, Jaffray CE, Bunnett NW, Grady EF, Kirkwood KS. Neutral endopeptidase determines the severity of pancreatitis-associated lung injury. J Surg Res. 2005 Sep; 128(1):21-7. PMID: 15993898.
      View in: PubMed
    24. Hutter MM, Wick EC, Day AL, Maa J, Zerega EC, Richmond AC, Jordan TH, Grady EF, Mulvihill SJ, Bunnett NW, Kirkwood KS. Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R). Pancreas. 2005 Apr; 30(3):260-5. PMID: 15782105.
      View in: PubMed
    25. Lu EJ, Curet MJ, El-Sayed YY, Kirkwood KS. Medical versus surgical management of biliary tract disease in pregnancy. Am J Surg. 2004 Dec; 188(6):755-9. PMID: 15619495.
      View in: PubMed
    26. Lightner AM, Glasgow RE, Jordan TH, Krassner AD, Way LW, Mulvihill SJ, Kirkwood KS. Pancreatic resection in the elderly. J Am Coll Surg. 2004 May; 198(5):697-706. PMID: 15110802.
      View in: PubMed
    27. Kim EH, Hoge SG, Lightner AM, Grady EF, Coelho AM, Kirkwood KS. Activation of nociceptive neurons in T9 and T10 in cerulein pancreatitis. J Surg Res. 2004 Apr; 117(2):195-201. PMID: 15047123.
      View in: PubMed
    28. Kerlan RK, LaBerge JM, Wilson MW, Gordon RL, Kirkwood K, Sawhney R. SIR 2003 film panel case 5: massive hemorrhage from portal vein disruption. J Vasc Interv Radiol. 2003 Jun; 14(6):797-802. PMID: 12817050.
      View in: PubMed
    29. Abedin MZ, Narins SC, Park EH, Smith PR, Kirkwood KS. Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogs. Dig Dis Sci. 2002 Oct; 47(10):2192-210. PMID: 12395892.
      View in: PubMed
    30. Lightner AM, Jordan TH, Bunnett NW, Grady EF, Kirkwood KS. Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury. Surgery. 2002 Aug; 132(2):193-9. PMID: 12219011.
      View in: PubMed
    31. Lightner AM, Kirkwood KS. Pathophysiology of gallstone pancreatitis. Front Biosci. 2001 Oct 01; 6:E66-76. PMID: 11578966.
      View in: PubMed
    32. Kirkwood KS, Bunnett NW, Maa J, Castagliolo I, Liu B, Gerard N, Zacks J, Pothoulakis C, Grady EF. Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2):G544-51. PMID: 11447035.
      View in: PubMed
    33. Maa J, Grady EF, Kim EH, Yoshimi SK, Hutter MM, Bunnett NW, Kirkwood KS. NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation. Am J Physiol Gastrointest Liver Physiol. 2000 Oct; 279(4):G726-32. PMID: 11005759.
      View in: PubMed
    34. Maa J, Grady EF, Yoshimi SK, Drasin TE, Kim EH, Hutter MM, Bunnett NW, Kirkwood KS. Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice. Surgery. 2000 Aug; 128(2):232-9. PMID: 10922997.
      View in: PubMed
    35. Grady EF, Yoshimi SK, Maa J, Valeroso D, Vartanian RK, Rahim S, Kim EH, Gerard C, Gerard N, Bunnett NW, Kirkwood KS. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice. Br J Pharmacol. 2000 Jun; 130(3):505-12. PMID: 10821777; PMCID: PMC1572103.
    36. Kirkwood KS, Kim EH, He XD, Calaustro EQ, Domush C, Yoshimi SK, Grady EF, Maa J, Bunnett NW, Debas HT. Substance P inhibits pancreatic exocrine secretion via a neural mechanism. Am J Physiol. 1999 08; 277(2):G314-20. PMID: 10444445.
      View in: PubMed
    37. Corvera CU, Kirkwood KS. Recent advances. General surgery. BMJ. 1997 Sep 06; 315(7108):586-9. PMID: 9302958; PMCID: PMC2127394.
    38. Kirkwood KS, Khitin LM, Barwick KW. Prognostic indicators for cancer. Gastric cancer. Surg Oncol Clin N Am. 1997 Jul; 6(3):495-514. PMID: 9210353.
      View in: PubMed
    39. Figini M, Emanueli C, Grady EF, Kirkwood K, Payan DG, Ansel J, Gerard C, Geppetti P, Bunnett N. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. Am J Physiol. 1997 Apr; 272(4 Pt 1):G785-93. PMID: 9142909.
      View in: PubMed
    40. Kirkwood KS, Debas HT. Neuroendocrine tumors: common presentations of uncommon diseases. Compr Ther. 1995 Dec; 21(12):719-25. PMID: 8789136.
      View in: PubMed