Carla Perissinotto, MD, MHS

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address490 Illinois Street, #82S
San Francisco CA 94158
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    University of California, San FranciscoFellowship2010Geriatrics
    University of California, San FranciscoResidency 2009Internal Medicine
    Tufts UniversityM.D.2006School of Medicine
    Johns Hopkins UniversityMHS2003School of Public Health
    Barnard College, Columbia UniversityBA2000Anthropology
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

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    From 2017-2021, Dr. Carla Perissinotto served as the first Associate Chief for Geriatrics Clinical Programs at UCSF. Given the growth of clinical programs, the associate chief oversees and manages both inpatient and outpatient clinical programs which include Care at Home, Geriatrics consultation in the outpatient setting, and the new Acute Care for the Elderly (ACE) unit at Moffitt-Long Hospital, Orthopedic CO-Management programs and programs which are in development.

    Carla is a Professor in the Division of Geriatrics, Department of Medicine. Carla is Board Certified in Internal Medicine, Geriatrics and Palliative Medicine. Carla is dedicated to working in both community and academic settings. Her main clinical work has been in home-based care, and she worked in UCSF Care at Home for over 10 years--which provides medical care to home bound older adults, and in embedded Geriatrics consult practices. From 2008-2017, Carla served as a primary care and consulting Geriatrician at the Over60 Health Center in Berkeley.

    Carla joined the faculty in August 2010 as a clinician-educator and has received multiple awards for her excellence in teaching. Carla is passionate about working with diverse communities and improving the training of internal medicine residents and all learners in the care of elderly patients. Carla also has a special interest in teaching primary care doctors how to more effectively recognize cognitive impairment in the outpatient primary care setting. Carla was also a recipient of the highly-competitive HRSA Geriatric Academic Career Award 2010-2015, with which she developed curricula to teach a wide range of learners on the care of elderly patients in diverse settings. Carla has also gained national and international recognition for her research on the effects of loneliness on the health of older adults. She is frequently invited to discuss her research and discuss the clinical and policy implications of the health effects of loneliness.

    At UCSF, she attends on the inpatient Internal Medicine Service, providers Geriatrics consultation in Women's Health Primary Care, the Positive Health 360 practice, and provides primary care to homebound older adults through UCSF Care at Home in San Francisco. Carla is passionate about the care of vulnerable elders and truly believes in sharing this excitement with residents, and other learners via lectures, bedside teaching, small group teaching, home visits, and visits to community senior centers.

    From 2008-2017, Carla spent a portion of her clinical time at the Over 60 Health Center, a Federally Qualified Health Center, serving adults over age 55 in Alameda County. At Over 60, Carla directed the educational programs for UCSF learners, and focused on practice change by establishing a team-based model for community-based Geriatrics seeing adults across a continuum of care.

    Carla has also had the privilege to work in clinical settings internationally, most notably, El Salvador, Kenya and Mexico. Annually, she volunteers in Chiapas, Mexico at the Hospital San Carlos ( which serves the indigenous people of Chiapas. Carla has written about these experiences on GeriPal. She continues to work on improving the care of older patients in low resource settings across the globe, and has created an opportunity for trainees to volunteer in Chiapas alongside of her.

    Academic Focus:
    Carla published a paper in the Archives of Internal Medicine on loneliness in Older Adults in 2012 which gained worldwide recognition and has sparked more conversation in the medical community about the health effects of loneliness. Because of the wide prevalence of loneliness in older adults, there has been significant interest from multiple organizations hoping to explore ways to better identify, and intervene on loneliness. Carla is currently exploring potential future research and policy endeavors focused on loneliness.

    As a Clinician-educator, Carla is dedicated to improving the Geriatrics training of Internal Medicine residents. Carla is interested ways to improve and integrate Geriatrics curriculum into general medicine practices. She has focused on providing community Geriatrics electives to residents, creating a housecalls program for residents, and embedding Geriatrics into General Medicine and specialty clinics.
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. "Relationships, Very Quickly, Turn to Nothing": Loneliness, Social Isolation, and Adaptation to Changing Social Lives Among Persons Living With Dementia and Care Partners. Gerontologist. 2024 Apr 01; 64(4). Kotwal AA, Allison TA, Halim M, Garrett SB, Perissinotto CM, Ritchie CS, Smith AK, Harrison KL. PMID: 38499400; PMCID: PMC10948338.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. What Are "Social Prescriptions" and How Should They Be Integrated Into Care Plans? AMA J Ethics. 2023 Nov 01; 25(11):E795-801. Hough K, Kotwal AA, Boyd C, Tha SH, Perissinotto C. PMID: 38085581.
      View in: PubMed   Mentions: 1     Fields:    
    3. The Role of Digital Technologies in Facilitating Psychosocial Resilience to Sudden Social Isolation Among Older Adults: Lessons Learned from the COVID-19 Pandemic. J Appl Gerontol. 2023 Dec; 42(12):2348-2359. Newmark RL, Allison TA, Smith AK, Perissinotto CM, Tha SH, Kotwal AA. PMID: 37536316.
      View in: PubMed   Mentions:    Fields:    
    4. Social Isolation and Loneliness as Medical Issues. N Engl J Med. 2023 Jan 14. Holt-Lunstad J, Perissinotto C. PMID: 36648080.
      View in: PubMed   Mentions: 9     Fields:    
    5. End-of-life health care use among socially isolated and cognitively impaired older adults. J Am Geriatr Soc. 2023 03; 71(3):880-887. Kotwal AA, Cenzer IS, Yaffe K, Perissinotto C, Smith AK. PMID: 36420540; PMCID: PMC10023302.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Loneliness Among Older Adults. Health Aff (Millwood). 2022 10; 41(10):1530. Rudy ET, McNamara KC, Parker A, Kotwal AA, Perissinotto CM. PMID: 36190881.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Key Elements and Mechanisms of a Peer-Support Intervention to Reduce Loneliness and Isolation among Low-Income Older Adults: A Qualitative Implementation Science Study. J Appl Gerontol. 2022 12; 41(12):2574-2582. Fuller SM, Kotwal AA, Tha SH, Hill D, Perissinotto C, Myers JJ. PMID: 36053132; PMCID: PMC9669726.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    8. Persistent loneliness due to COVID-19 over 18 months of the pandemic: A prospective cohort study. J Am Geriatr Soc. 2022 12; 70(12):3469-3479. Kotwal AA, Batio S, Wolf MS, Covinsky KE, Yoshino Benavente J, Perissinotto CM, O'Conor RM. PMID: 36054661; PMCID: PMC9539351.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    9. The True Cause of Death. JAMA. 2022 07 05; 328(1):19-20. Perissinotto CM. PMID: 35788791.
      View in: PubMed   Mentions:    Fields:    
    10. Multimorbidity patterns in adult day health center clients with dementia: a latent class analysis. BMC Geriatr. 2022 06 22; 22(1):514. Sadarangani T, Perissinotto C, Boafo J, Zhong J, Yu G. PMID: 35733122; PMCID: PMC9216285.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. A single question assessment of loneliness in older adults during the COVID-19 pandemic: A nationally-representative study. J Am Geriatr Soc. 2022 05; 70(5):1342-1345. Kotwal AA, Cenzer IS, Waite LJ, Smith AK, Perissinotto CM, Hawkley LC. PMID: 35141875; PMCID: PMC9106870.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    12. Isolation in the Time of Covid: What is the True Cost, and How Will we Know? Am J Health Promot. 2022 02; 36(2):380-382. Holt-Lunstad J, Perissinotto CM. PMID: 35042426.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Attitudes of Homebound Older Adults and Their Caregivers Toward Research and Participation as Research Advisors. Gerontologist. 2021 11 15; 61(8):1202-1210. Eaton England AL, Ritchie CS, Mickler A, Perissinotto CM, Garrigues SK, Leff B, Sheehan OC, Harrison KL. PMID: 33216908; PMCID: PMC8679039.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Impact of the COVID-19 Pandemic on Loneliness and Social Isolation: A Multi-Country Study. Int J Environ Res Public Health. 2021 Sep 23; 18(19). O'Sullivan R, Burns A, Leavey G, Leroi I, Burholt V, Lubben J, Holt-Lunstad J, Victor C, Lawlor B, Vilar-Compte M, Perissinotto CM, Tully MA, Sullivan MP, Rosato M, Power JM, Tiilikainen E, Prohaska TR. PMID: 34639283; PMCID: PMC8508181.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCellsPHPublic Health
    15. The epidemiology of social isolation and loneliness among older adults during the last years of life. J Am Geriatr Soc. 2021 11; 69(11):3081-3091. Kotwal AA, Cenzer IS, Waite LJ, Covinsky KE, Perissinotto CM, Boscardin WJ, Hawkley LC, Dale W, Smith AK. PMID: 34247388; PMCID: PMC8595510.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    16. A Home-Based Care Research Agenda by and for Homebound Older Adults and Caregivers. J Appl Gerontol. 2021 12; 40(12):1715-1721. Leff B, Sheehan OC, Harrison KL, Eaton England A, Mickler A, Basyal PS, Garrigues SK, Schuchman M, Perissinotto C, Garrett SB, Ritchie CS. PMID: 33792428; PMCID: PMC8604613.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Understanding the Daily Experiences and Perceptions of Homebound Older Adults and Their Caregivers: A Qualitative Study. J Appl Gerontol. 2021 12; 40(12):1722-1732. Mickler AK, Leff B, Eaton England A, Garrigues SK, Schuchman M, Perissinotto C, Ritchie CS, Harrison KL, Sheehan OC. PMID: 33522364; PMCID: PMC8549343.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Virtual Research Stakeholder Groups with Isolated Homebound Elders and Caregivers: Lessons Learned Relevant to Research during Pandemics. J Palliat Med. 2021 04; 24(4):481-483. Harrison KL, Leff B, Garrigues SK, Eaton England AL, Perissinotto CM, Sheehan OC, Mickler AK, Basyal PS, Ritchie CS. PMID: 33395555; PMCID: PMC7987355.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    19. Social Isolation and Loneliness Among San Francisco Bay Area Older Adults During the COVID-19 Shelter-in-Place Orders. J Am Geriatr Soc. 2021 01; 69(1):20-29. Kotwal AA, Holt-Lunstad J, Newmark RL, Cenzer I, Smith AK, Covinsky KE, Escueta DP, Lee JM, Perissinotto CM. PMID: 32965024; PMCID: PMC7536935.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCellsPHPublic Health
    20. Consensus statement: loneliness in older adults, the 21st century social determinant of health? BMJ Open. 2020 08 11; 10(8):e034967. Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J, O'Sullivan R, Perissinotto C, van Tilburg T, Tully M, Victor C, Fried L. PMID: 32788184; PMCID: PMC7422633.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    21. Meeting the Care Needs of Older Adults Isolated at Home During the COVID-19 Pandemic. JAMA Intern Med. 2020 06 01; 180(6):819-820. Steinman MA, Perry L, Perissinotto CM. PMID: 32297903.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCellsPHPublic Health
    22. Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation. Int Psychogeriatr. 2020 08; 32(8):955-979. Ternes K, Iyengar V, Lavretsky H, Dawson WD, Booi L, Ibanez A, Vahia I, Reynolds C, DeKosky S, Cummings J, Miller B, Perissinotto C, Kaye J, Eyre HA. PMID: 32019621; PMCID: PMC7423685.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    23. A unified approach to loneliness. Lancet. 2020 01 11; 395(10218):114. Fried L, Prohaska T, Burholt V, Burns A, Golden J, Hawkley L, Lawlor B, Leavey G, Lubben J, O'Sullivan R, Perissinotto C, van Tilburg T, Tully M, Victor C. PMID: 31929010.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    24. Capsule Commentary on O'Conor et al., Perceived Adequacy of Tangible Social Support and Associations with Health Outcomes Among Older Primary Care Patients. J Gen Intern Med. 2019 11; 34(11):2580. Perissinotto C. PMID: 31485966; PMCID: PMC6848391.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Reply to: Older People's Loneliness in Clinical Work. J Am Geriatr Soc. 2019 10; 67(10):2212-2213. Perissinotto C, Holt-Lunstad J, Periyakoil VS, Covinsky K. PMID: 31381836.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Pain and Loneliness: Results of a Nationally-Representative Survey of Community-Dwelling Older Adults. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2019; 67(S1):S54-S55. Kotwal, A., Waite, L., Dale, W., Perissinotto, C. M., Covinsky, K., & Smith, A. K.
    28. A Practical Approach to Assessing and Mitigating Loneliness and Isolation in Older Adults. J Am Geriatr Soc. 2019 04; 67(4):657-662. Perissinotto C, Holt-Lunstad J, Periyakoil VS, Covinsky K. PMID: 30762228.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    29. A Quality of Care Framework for Home-Based Medical Care. J Am Med Dir Assoc. 2018 10; 19(10):818-823. Ritchie CS, Leff B, Garrigues SK, Perissinotto C, Sheehan OC, Harrison KL. PMID: 30056010; PMCID: PMC6392035.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Loneliness in Older Adults Living with HIV. AIDS Behav. 2018 May; 22(5):1475-1484. Greene M, Hessol NA, Perissinotto C, Zepf R, Hutton Parrott A, Foreman C, Whirry R, Gandhi M, John M. PMID: 29151199; PMCID: PMC6756479.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    31. "I Feel Trapped": The Tension Between Personal and Structural Factors of Social Isolation and the Desire for Social Integration Among Older Residents of a High-Crime Neighborhood. Gerontologist. 2018 Jan 18; 58(1):79-88. Portacolone E, Perissinotto C, Yeh JC, Greysen SR. PMID: 28329804; PMCID: PMC5881710.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic Health
    32. Capsule Commentary on Wolff, et al., A Look at Person- and Family-Centered Care Among Older Adults: Results from a National Survey. J Gen Intern Med. 2015 Oct; 30(10):1536. Perissinotto CM, Walter LC. PMID: 26001544; PMCID: PMC4579225.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA Intern Med. 2015 Jun; 175(6):890. Rogers SE, Klein L, Perissinotto CM. PMID: 25822770.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Living alone, socially isolated or lonely--what are we measuring? J Gen Intern Med. 2014 Nov; 29(11):1429-31. Perissinotto CM, Covinsky KE. PMID: 25092012; PMCID: PMC4238196.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    35. Health status in elderly persons living alone--reply. JAMA Intern Med. 2013 Feb 25; 173(4):323-4. Perissinotto C, Covinsky KE. PMID: 23440237.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Loneliness in older persons: a predictor of functional decline and death. Arch Intern Med. 2012 Jul 23; 172(14):1078-83. Perissinotto CM, Stijacic Cenzer I, Covinsky KE. PMID: 22710744; PMCID: PMC4383762.
      View in: PubMed   Mentions: 375     Fields:    Translation:Humans
    37. Preventing dementia: is there hope for progress? Am Fam Physician. 2011 May 01; 83(9):1034-5. Perissinotto CM, Valcour V. PMID: 21534514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    38. Unemployment, job retention, and productivity loss among employees with depression. Psychiatr Serv. 2004 Dec; 55(12):1371-8. Lerner D, Adler DA, Chang H, Lapitsky L, Hood MY, Perissinotto C, Reed J, McLaughlin TJ, Berndt ER, Rogers WH. PMID: 15572564; PMCID: PMC4283817.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    39. The work impact of dysthymia in a primary care population. Gen Hosp Psychiatry. 2004 Jul-Aug; 26(4):269-76. Adler DA, Irish J, McLaughlin TJ, Perissinotto C, Chang H, Hood M, Lapitsky L, Rogers WH, Lerner D. PMID: 15234821; PMCID: PMC4269288.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
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