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Kristine Yaffe, MD

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
Phone415-221-4810 ext. 3985
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    Other Positions
    Title(s)Roy and Marie Scola Endowed Chair

    Title(s)Vice Chair of Research in Psychiatry


    Collapse Biography 
    Collapse Education and Training
    Yale University BSBiology-Psychology
    University of Pennsylvania M.D.School of Medicine
    University of California, San FranciscoResidency Neurology and Psychiatry
    University of California, San FranciscoFellowship Geriatric Psychiatry
    University of California, San FranciscoFellowshipClinical Epidemiology
    Collapse Awards and Honors
    American Academy of Neurology2017Potamkin Prize for Dementia Research
    American College of Psychiatrists 2015Research Award in Geriatric Psychiatry
    Thomson Reuters2014World’s Most Influential Scientific Minds
    American Association for Geriatric Psychiatry2014Distinguished Scientist Award
    UCSF2013Faculty Research Award in Clinical Science
    Johns Hopkins Division of Geriatric Psychiatry and Neuropsychiatry2013John Mackey Award for Excellence in Dementia Care
    International Conference on Alzheimer’s Disease and Related Disorders2011  - 2013Chair, Scientific Planning Committee
    UCSF Department of Psychiatry2010Royer Award for Academic Excellence in Psychiatry
    American Academy of Neurology2005Research Award in Geriatrics

    Collapse Overview 
    Collapse Overview
    Kristine Yaffe, MD, is a Professor of Psychiatry, Neurology and Epidemiology, the Roy and Marie Scola Endowed Chair and Vice Chair of Research in Psychiatry at UCSF. Dr. Yaffe is dually trained in neurology and psychiatry and completed postdoctoral training in epidemiology and geriatric psychiatry, all at UCSF. In addition to her positions at UCSF, Dr. Yaffe is the Chief of Neuropsychiatry and the Director of the Memory Disorders Clinic at the San Francisco Veteran’s Affairs Medical Center. In her research, clinical work, and mentoring, she has worked towards improving the care of patients with cognitive disorders and other geriatric neuropsychiatric conditions.

    Dr. Yaffe's research focuses on the epidemiology of cognitive aging and dementia. As the principal investigator of multiple grants from the NIH, Department of Defense, and several foundations, she is a leading expert in the modifiable risk factors of dementia, and she has published over 500 peer-reviewed articles (H-index=130; recognized by Clarivate Analytics as one of the most highly cited researchers in her field). Dr. Yaffe served as the Co-Chair of the United States’ Institute of Medicine’s Committee on Cognitive Aging which released a report in 2015 entitled, “Cognitive Aging: Progress in Understanding and Opportunities for Action”. She is a member of the Beeson Scientific Advisory Board and the Global Council on Brain Health. Dr. Yaffe has received several awards for her distinguished, scholarly work, including the American Association for Geriatric Psychiatry’s Distinguished Scientist Award and the American Academy of Neurology’s Potamkin Prize for Alzheimer’s Research.

    Collapse Research 
    Collapse Research Activities and Funding
    Genetics, comorbidities, and ethnicity: Effects of TBI on Dementia
    Department of Army W81XWH-18-1-0692Sep 30, 2018 - Sep 29, 2021
    Role: Multiple Principal Investigator
    An Alzheimer's Blood Test for Primary Care
    NIH/NIA R01AG058537Jun 1, 2018 - May 31, 2021
    Role: Multiple Principal Investigator
    Connection Between Depressive Symptoms and Dementia: When Best to Intervene?
    Alzheimer’s Drug Discovery Foundation Jun 1, 2018 - May 31, 2020
    Role: Multiple Principal Investigator
    Leveraging New Data on Cognitive Aging & Dementia from Around the World
    Global Brain Health Institute Jun 1, 2018 - May 31, 2020
    Role: Multiple Principal Investigator
    Paul B. Beeson Emerging Leaders Career Development Awards in Aging Annual Meeting
    NIH/NIA R13AG058415Sep 15, 2017 - May 31, 2022
    Role: Multiple Principal Investigator
    Multidomain Alzheimers Risk Reduction Study (MARRS) Pilot
    NIH/NIA R01AG057508Sep 15, 2017 - Apr 30, 2021
    Role: Multiple Principal Investigator
    Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans
    NIH/NIA R01AG054073Sep 1, 2017 - May 31, 2022
    Role: Multiple Principal Investigator
    Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment
    NIH/NIA RF1AG054443May 1, 2017 - Apr 30, 2021
    Role: Multiple Principal Investigator
    Risk and Resiliency for Dementia: Comparison of Male and Female Veterans
    Department of Defense W81XWH1610507Aug 15, 2016 - Aug 14, 2019
    Role: Principal Investigator
    Chronic Effects of Neurotrauma Consortium: Epidemiology Project
    Department of Defense/VA W81XWH-12-PHTBI-CENCFeb 1, 2015 - Sep 29, 2019
    Role: Principal Investigator
    Determinants of Midlife & Longitudinal Change in Cognitive Function: CARDIA Study
    NIH/NHLBI R01HL122658Dec 1, 2014 - Nov 30, 2018
    Role: Multiple Principal Investigator
    Blood biomarker profile of TBI-associated cognitive impairment
    Department of Defense W81XWH1420137Sep 30, 2014 - Sep 29, 2019
    Role: Principal Investigator
    Long Term Depressive Symptom Course &Adverse Health Outcomes among Older Women
    NIH R01MH086498Mar 4, 2010 - Feb 28, 2014
    Role: Principal Investigator
    Predictors of cognitive aging across the lifecourse
    NIH/NIA K24AG031155Sep 30, 2007 - Nov 30, 2020
    Role: Principal Investigator
    Cognitive Decline in Chronic Renal Insufficiency
    NIH R01DK069406Sep 15, 2005 - May 31, 2015
    Role: Multiple Principal Investigator
    Metabolic Syndrome and Cognitive Impairment
    NIH/NIDDK R21DK070713Sep 1, 2005 - Aug 31, 2007
    Role: Principal Investigator
    Changes in Sleep and Cognition in Older Women
    NIH/NIA R01AG026720Jul 1, 2005 - Mar 31, 2017
    Role: Multiple Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH/NIA P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Sex Hormones, Related Polymorphisms &Cognitive Decline
    NIH/NIA R01AG021918Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Frontotemporal Dementia: Genes, Images, and Emotions
    NIH/NIA P01AG019724Jul 1, 2001 - May 31, 2022
    Role: Co-Investigator
    ESTROGEN COMPOUNDS, COGNITION &DEMENTIA IN OLDER WOMEN
    NIH/NIA K23AG000888Sep 30, 1998 - Feb 28, 2005
    Role: Principal Investigator
    ESTROGEN COMPOUNDS, COGNITION &DEMENTIA IN OLDER WOMEN
    NIH/NIA K08AG000888Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Study of Osteoporotic Fractures
    NIH/NIA R01AG005407Feb 1, 1986 - May 31, 2017
    Role: Multiple Principal Investigator

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    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Greenwood EA, Yaffe K, Wellons MF, Cedars MI, Huddleston HG. Depression Over the Lifespan in a Population-Based Cohort of Women With Polycystic Ovary Syndrome: Longitudinal Analysis. J Clin Endocrinol Metab. 2019 Jul 01; 104(7):2809-2819. PMID: 30985868.
      View in: PubMed
    2. Sexton CE, Sykara K, Karageorgiou E, Zitser J, Rosa T, Yaffe K, Leng Y. Connections Between Insomnia and Cognitive Aging. Neurosci Bull. 2019 Jun 20. PMID: 31222500.
      View in: PubMed
    3. Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K. Objective napping, cognitive decline, and risk of cognitive impairment in older men. Alzheimers Dement. 2019 Jun 11. PMID: 31227429.
      View in: PubMed
    4. Sexton CE, Yaffe K. Population-Based Approaches to Dementia Prevention. J Alzheimers Dis. 2019 May 25. PMID: 31156162.
      View in: PubMed
    5. Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, Hillman DR, Johnson WC, Lederer DJ, Lee J, Loredo JS, Mei H, Mukherjee S, Patel SR, Post WS, Purcell SM, Ramos AR, Reid KJ, Rice K, Shah NA, Sofer T, Taylor KD, Thornton TA, Wang H, Yaffe K, Zee PC, Hanis CL, Palmer LJ, Rotter JI, Stone KL, Tranah GJ, Wilson JG, Sunyaev SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S. Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep. PLoS Genet. 2019 04; 15(4):e1007739. PMID: 30990817.
      View in: PubMed
    6. Wassenaar TM, Yaffe K, van der Werf YD, Sexton CE. Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies. Neurobiol Aging. 2019 Apr 11; 80:56-70. PMID: 31103633.
      View in: PubMed
    7. Barha CK, Best JR, Rosano C, Yaffe K, Catov JM, Liu-Ambrose T. Sex-specific relationship between long-term maintenance of physical activity and cognition in the Health ABC Study: Potential role of hippocampal and dorsolateral prefrontal cortex volume. J Gerontol A Biol Sci Med Sci. 2019 Apr 08. PMID: 30958523.
      View in: PubMed
    8. Harrison KL, Hunt LJ, Ritchie CS, Yaffe K. Dying With Dementia: Underrecognized and Stigmatized. J Am Geriatr Soc. 2019 Mar 25. PMID: 30908605.
      View in: PubMed
    9. Bancks M, Alonso A, Allen N, Yaffe K, Carnethon M. Temporal trends in cognitive function of older US adults associated with population changes in demographic and cardiovascular profiles. J Epidemiol Community Health. 2019 Jul; 73(7):612-618. PMID: 30885985.
      View in: PubMed
    10. McEvoy CT, Leng Y, Peeters GM, Kaup AR, Allen IE, Yaffe K. Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: a systematic review and meta-analysis. Nutr Res. 2019 Jun; 66:1-12. PMID: 31022563.
      View in: PubMed
    11. McEvoy CT, Hoang T, Sidney S, Steffen LM, Jacobs DR, Shikany JM, Wilkins JT, Yaffe K. Dietary patterns during adulthood and cognitive performance in midlife: The CARDIA study. Neurology. 2019 Apr 02; 92(14):e1589-e1599. PMID: 30842290.
      View in: PubMed
    12. Rosso AL, Metti AL, Faulkner K, Redfern M, Yaffe K, Launer L, Elizabeth Shaaban C, Nadkarni NK, Rosano C. Complex Walking Tasks and Risk for Cognitive Decline in High Functioning Older Adults. J Alzheimers Dis. 2019 Feb 21. PMID: 30814353.
      View in: PubMed
    13. Wang H, Cade BE, Sofer T, Sands SA, Chen H, Browning SR, Stilp AM, Louie TL, Thornton TA, Johnson WC, Below JE, Conomos MP, Evans DS, Gharib SA, Guo X, Wood AC, Mei H, Yaffe K, Loredo JS, Ramos AR, Barrett-Connor E, Ancoli-Israel S, Zee PC, Arens R, Shah NA, Taylor KD, Tranah GJ, Stone KL, Hanis CL, Wilson JG, Gottlieb DJ, Patel SR, Rice K, Post WS, Rotter JI, Sunyaev SR, Cai J, Lin X, Purcell SM, Laurie CC, Saxena R, Redline S, Zhu X. Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans. Hum Mol Genet. 2019 Feb 15; 28(4):675-687. PMID: 30403821.
      View in: PubMed
    14. Duarte S, Hoang T, Ewing SK, Cawthon PM, Cummings S, Stone KL, Cauley JA, Bauer DC, Hillier TA, Yaffe K. Glycated Peptide Levels Are Associated With Cognitive Decline Among Nondiabetic Older Women. J Gerontol A Biol Sci Med Sci. 2019 Feb 15; 74(3):396-399. PMID: 29741593.
      View in: PubMed
    15. Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol. 2019 Mar; 18(3):307-318. PMID: 30784558.
      View in: PubMed
    16. Yaffe K. Prevention of Cognitive Impairment With Intensive Systolic Blood Pressure Control. JAMA. 2019 02 12; 321(6):548-549. PMID: 30688980.
      View in: PubMed
    17. Casaletto KB, Elahi FM, Staffaroni AM, Walters S, Contreras WR, Wolf A, Dubal D, Miller B, Yaffe K, Kramer JH. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in "normal" adults. Neurobiol Aging. 2019 May; 77:13-19. PMID: 30772736.
      View in: PubMed
    18. Kaup AR, Harmell AL, Yaffe K. Conscientiousness Is Associated with Lower Risk of Dementia among Black and White Older Adults. Neuroepidemiology. 2019; 52(1-2):86-92. PMID: 30602170.
      View in: PubMed
    19. Béjot Y, Yaffe K. Ageing Population: A Neurological Challenge. Neuroepidemiology. 2019; 52(1-2):76-77. PMID: 30602150.
      View in: PubMed
    20. La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E. Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers. J Alzheimers Dis. 2019; 67(3):911-921. PMID: 30689583.
      View in: PubMed
    21. Lwi SJ, Barnes DE, Xia F, Peltz C, Hoang T, Yaffe K. Ten-Year Prevalence of Cognitive Impairment Diagnoses and Associated Medical and Psychiatric Conditions in a National Cohort of Older Female Veterans. Am J Geriatr Psychiatry. 2019 Apr; 27(4):417-425. PMID: 30704839.
      View in: PubMed
    22. Yaffe K, Lwi SJ, Hoang TD, Xia F, Barnes DE, Maguen S, Peltz CB. Military-related risk factors in female veterans and risk of dementia. Neurology. 2019 Jan 15; 92(3):e205-e211. PMID: 30541865.
      View in: PubMed
    23. Zeki Al Hazzouri A, Vittinghoff E, Zhang Y, Pletcher MJ, Moran AE, Bibbins-Domingo K, Golden SH, Yaffe K. Use of a pooled cohort to impute cardiovascular disease risk factors across the adult life course. Int J Epidemiol. 2018 Dec 07. PMID: 30535320.
      View in: PubMed
    24. Yaffe K, Barnes DE, Rosenberg D, Dublin S, Kaup AR, Ludman EJ, Vittinghoff E, Peltz CB, Renz AD, Adams KJ, Larson EB. Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT): Study Protocol. J Alzheimers Dis. 2018 Nov 23. PMID: 30475764.
      View in: PubMed
    25. Aliberti MJR, Cenzer IS, Smith AK, Lee SJ, Yaffe K, Covinsky KE. Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition. J Am Geriatr Soc. 2019 Mar; 67(3):477-483. PMID: 30468258.
      View in: PubMed
    26. Brenowitz WD, Kaup AR, Lin FR, Yaffe K. Multiple sensory impairment is associated with increased risk of dementia among black and white older adults. J Gerontol A Biol Sci Med Sci. 2018 Nov 18. PMID: 30452551.
      View in: PubMed
    27. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 Feb; 137(2):209-226. PMID: 30413934.
      View in: PubMed
    28. Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT, Landau S, Manley G, McKee A, Perl D, Schneider JA, Weiner M, Wellington C, Yaffe K, Bain L, Pacifico AM, Carrillo MC. Military-related risk factors for dementia. Alzheimers Dement. 2018 Dec; 14(12):1651-1662. PMID: 30415806.
      View in: PubMed
    29. Bayen E, Possin KL, Chen Y, Cleret de Langavant L, Yaffe K. Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome. JAMA Neurol. 2018 Nov 01; 75(11):1399-1406. PMID: 30032260.
      View in: PubMed
    30. Swenor BK, Wang J, Varadaraj V, Rosano C, Yaffe K, Albert M, Simonsick EM. Vision Impairment and Cognitive Outcomes in Older Adults: The Health ABC Study. J Gerontol A Biol Sci Med Sci. 2018 Oct 25. PMID: 30358809.
      View in: PubMed
    31. Barha CK, Liu-Ambrose T, Best JR, Yaffe K, Rosano C. Sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults: evidence from the health ABC study. Neurobiol Aging. 2019 Feb; 74:161-170. PMID: 30448615.
      View in: PubMed
    32. Nosheny RL, Camacho MR, Insel PS, Flenniken D, Fockler J, Truran D, Finley S, Ulbricht A, Maruff P, Yaffe K, Mackin RS, Weiner MW. Online study partner-reported cognitive decline in the Brain Health Registry. Alzheimers Dement (N Y). 2018; 4:565-574. PMID: 30386821.
      View in: PubMed
    33. Bancks MP, Carnethon MR, Jacobs DR, Launer LJ, Reis JP, Schreiner PJ, Shah RV, Sidney S, Yaffe K, Yano Y, Allen NB. Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes Care. 2018 12; 41(12):2579-2585. PMID: 30305344.
      View in: PubMed
    34. Williams SM, Peltz C, Yaffe K, Schulz P, Sierks MR. CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury. Neurology. 2018 Oct 09; 91(15):702-709. PMID: 30297502.
      View in: PubMed
    35. Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K. Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol. 2018 10 01; 47(5):1679-1686. PMID: 29873737.
      View in: PubMed
    36. Whitson HE, Cronin-Golomb A, Cruickshanks KJ, Gilmore GC, Owsley C, Peelle JE, Recanzone G, Sharma A, Swenor B, Yaffe K, Lin FR. American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory Impairment and Cognitive Decline in Older Adults. J Am Geriatr Soc. 2018 Nov; 66(11):2052-2058. PMID: 30248173.
      View in: PubMed
    37. Lai AX, Kaup AR, Yaffe K, Byers AL. High Occurrence of Psychiatric Disorders and Suicidal Behavior Across Dementia Subtypes. Am J Geriatr Psychiatry. 2018 Dec; 26(12):1191-1201. PMID: 30392777.
      View in: PubMed
    38. Brown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR. Biological Age, Not Chronological Age, Is Associated with Late-Life Depression. J Gerontol A Biol Sci Med Sci. 2018 Sep 11; 73(10):1370-1376. PMID: 28958059.
      View in: PubMed
    39. Ensrud KE, Lui LY, Langsetmo L, Vo TN, Taylor BC, Cawthon PM, Kilgore ML, McCulloch CE, Cauley JA, Stefanick ML, Yaffe K, Orwoll ES, Schousboe JT. Effects of Mobility and Multimorbidity on Inpatient and Postacute Health Care Utilization. J Gerontol A Biol Sci Med Sci. 2018 Sep 11; 73(10):1343-1349. PMID: 28645202.
      View in: PubMed
    40. Leng Y, Diem SJ, Stone KL, Yaffe K. Antidepressant Use and Cognitive Outcomes in Very Old Women. J Gerontol A Biol Sci Med Sci. 2018 Sep 11; 73(10):1390-1395. PMID: 29244058.
      View in: PubMed
    41. Kaup AR, Toomey R, Bangen KJ, Delano-Wood L, Yaffe K, Panizzon MS, Lyons MJ, Franz CE, Kremen WS. Interactive Effect of Traumatic Brain Injury and Psychiatric Symptoms on Cognition among Late Middle-Aged Men: Findings from the Vietnam Era Twin Study of Aging. J Neurotrauma. 2019 Jan 15; 36(2):338-347. PMID: 29978738.
      View in: PubMed
    42. Barnes DE, Byers AL, Gardner RC, Seal KH, Boscardin WJ, Yaffe K. Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans. JAMA Neurol. 2018 Sep 01; 75(9):1055-1061. PMID: 29801145.
      View in: PubMed
    43. Diem SJ, Vo TN, Langsetmo L, Schousboe JT, Yaffe K, Ensrud KE. Impact of Competing Risk of Mortality on Association of Cognitive Impairment With Risk of Hip Fracture in Older Women. J Bone Miner Res. 2018 Sep; 33(9):1595-1602. PMID: 29734471.
      View in: PubMed
    44. LeBlanc ES, Rizzo JH, Pedula KL, Yaffe K, Ensrud KE, Cauley JA, Cawthon PM, Cummings SR, Hillier TA. Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death. J Am Geriatr Soc. 2018 Oct; 66(10):1972-1979. PMID: 30151825.
      View in: PubMed
    45. Huang X, Meyers K, Liu X, Li X, Zhang T, Xia W, Hou J, Song A, He H, Li C, He S, Cai W, Zhong H, Huang C, Liu S, Wang H, Ling X, Ma P, Ye R, Xiao G, Li T, Ding D, Yaffe K, Chen H, Chen Y, Wu H. The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China. Front Psychiatry. 2018; 9:384. PMID: 30197608.
      View in: PubMed
    46. Rogers-Soeder TS, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Cauley JA, Ensrud KE, Paudel M, Barrett-Connor E, LeBlanc E, Stone K, Lane NE, Tranah G. Rest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc. 2018 Nov; 66(11):2136-2143. PMID: 30136716.
      View in: PubMed
    47. Byers AL, Lui LY, Vittinghoff E, Covinsky KE, Ensrud KE, Taylor B, Yaffe K. Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc. 2018 Oct; 66(10):1895-1901. PMID: 30094824.
      View in: PubMed
    48. Tranah GJ, Katzman SM, Lauterjung K, Yaffe K, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.3243A?>?G heteroplasmy affects multiple aging phenotypes and risk of mortality. Sci Rep. 2018 Aug 08; 8(1):11887. PMID: 30089816.
      View in: PubMed
    49. Cleret de Langavant L, Bayen E, Yaffe K. Unsupervised Machine Learning to Identify High Likelihood of Dementia in Population-Based Surveys: Development and Validation Study. J Med Internet Res. 2018 Jul 09; 20(7):e10493. PMID: 29986849.
      View in: PubMed
    50. Kaup AR, Xia F, Launer LJ, Sidney S, Nasrallah I, Erus G, Allen N, Yaffe K. Occupational cognitive complexity in earlier adulthood is associated with brain structure and cognitive health in midlife: The CARDIA study. Neuropsychology. 2018 Nov; 32(8):895-905. PMID: 29985017.
      View in: PubMed
    51. Bertenthal D, Yaffe K, Barnes DE, Byers AL, Gibson CJ, Seal KH. Do postconcussive symptoms from traumatic brain injury in combat veterans predict risk for receiving opioid therapy for chronic pain? Brain Inj. 2018; 32(10):1188-1196. PMID: 29985653.
      View in: PubMed
    52. Tranah GJ, Maglione JE, Yaffe K, Katzman SM, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly. Int J Geriatr Psychiatry. 2018 10; 33(10):1319-1326. PMID: 29984425.
      View in: PubMed
    53. Casaletto KB, Staffaroni AM, Elahi F, Fox E, Crittenden PA, You M, Neuhaus J, Glymour M, Bettcher BM, Yaffe K, Kramer JH. Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults. Am J Geriatr Psychiatry. 2018 Sep; 26(9):952-963. PMID: 30017239.
      View in: PubMed
    54. Leng X, Espeland MA, Manson JE, Stefanick ML, Gower EW, Hayden KM, Limacher MC, Vaughan L, Robinson J, Wallace R, Wassertheil-Smoller S, Yaffe K, Shumaker SA. Cognitive Function and Changes in Cognitive Function as Predictors of Incident Cardiovascular Disease: The Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2018 May 09; 73(6):779-785. PMID: 28977360.
      View in: PubMed
    55. Harhay MN, Xie D, Zhang X, Hsu CY, Vittinghoff E, Go AS, Sozio SM, Blumenthal J, Seliger S, Chen J, Deo R, Dobre M, Akkina S, Reese PP, Lash JP, Yaffe K, Kurella Tamura M. Cognitive Impairment in Non-Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2018 Oct; 72(4):499-508. PMID: 29728316.
      View in: PubMed
    56. Ensrud KE, Kats AM, Schousboe JT, Taylor BC, Cawthon PM, Hillier TA, Yaffe K, Cummings SR, Cauley JA, Langsetmo L. Frailty Phenotype and Healthcare Costs and Utilization in Older Women. J Am Geriatr Soc. 2018 Jul; 66(7):1276-1283. PMID: 29684237.
      View in: PubMed
    57. Gardner RC, Byers AL, Barnes DE, Li Y, Boscardin J, Yaffe K. Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study. Neurology. 2018 May 15; 90(20):e1771-e1779. PMID: 29669907.
      View in: PubMed
    58. Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K. Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol. 2018 Apr; 83(4):730-738. PMID: 29518257.
      View in: PubMed
    59. Seal KH, Bertenthal D, Barnes DE, Byers AL, Gibson CJ, Rife TL, Yaffe K. Traumatic Brain Injury and Receipt of Prescription Opioid Therapy for Chronic Pain in Iraq and Afghanistan Veterans: Do Clinical Practice Guidelines Matter? J Pain. 2018 Aug; 19(8):931-941. PMID: 29597083.
      View in: PubMed
    60. Djonlagic I, Aeschbach D, Harrison SL, Dean D, Yaffe K, Ancoli-Israel S, Stone K, Redline S. Associations between quantitative sleep EEG and subsequent cognitive decline in older women. J Sleep Res. 2018 Mar 05. PMID: 29508460.
      View in: PubMed
    61. Kilpatrick L, Houston DK, Wilson VK, Lovato J, Ayonayon HN, Cauley JA, Harris T, Simonsick EM, Yaffe K, Kritchevsky SB, Sink KM. Low 25-Hydroxyvitamin D Concentrations and Risk of Incident Cognitive Impairment in Black and White Older Adults: The Health ABC Study. J Nutr Gerontol Geriatr. 2018 Jan-Mar; 37(1):1-13. PMID: 29505349.
      View in: PubMed
    62. Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K. Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women. J Gerontol A Biol Sci Med Sci. 2018 03 02; 73(3):374-379. PMID: 28329031.
      View in: PubMed
    63. Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K. Corrigendum to: "Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women". J Gerontol A Biol Sci Med Sci. 2018 03 02; 73(3):419. PMID: 29155930.
      View in: PubMed
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    404. Johnson JK, Lui LY, Yaffe K. Executive function, more than global cognition, predicts functional decline and mortality in elderly women. J Gerontol A Biol Sci Med Sci. 2007 Oct; 62(10):1134-41. PMID: 17921427; PMCID: PMC2049089.
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    406. Yende S, Angus DC, Ding J, Newman AB, Kellum JA, Li R, Ferrell RE, Zmuda J, Kritchevsky SB, Harris TB, Garcia M, Yaffe K, Wunderink RG. 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1129-37. PMID: 17761618.
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    408. Schaap LA, Pluijm SM, Deeg DJ, Penninx BW, Nicklas BJ, Lips P, Harris TB, Newman AB, Kritchevsky SB, Cauley JA, Goodpaster BH, Tylavsky FA, Yaffe K, Visser M. Low testosterone levels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies. Clin Endocrinol (Oxf). 2008 Jan; 68(1):42-50. PMID: 17666086.
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    410. Jeste DV, Blazer D, Casey D, Meeks T, Salzman C, Schneider L, Tariot P, Yaffe K. ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology. 2008 Apr; 33(5):957-70. PMID: 17637610.
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    428. Yaffe K, Barnes D, Lindquist K, Cauley J, Simonsick EM, Penninx B, Satterfield S, Harris T, Cummings SR. Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort. Neurobiol Aging. 2007 Feb; 28(2):171-8. PMID: 17097195.
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    432. Kramer JH, Nelson A, Johnson JK, Yaffe K, Glenn S, Rosen HJ, Miller BL. Multiple cognitive deficits in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord. 2006; 22(4):306-11. PMID: 16931884; PMCID: PMC2631274.
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    434. Elkins JS, Whitmer RA, Sidney S, Sorel M, Yaffe K, Johnston SC. Midlife obesity and long-term risk of nursing home admission. Obesity (Silver Spring). 2006 Aug; 14(8):1472-8. PMID: 16988091.
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    436. Lyketsos CG, Colenda CC, Beck C, Blank K, Doraiswamy MP, Kalunian DA, Yaffe K. Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. Am J Geriatr Psychiatry. 2006 Jul; 14(7):561-72. PMID: 16816009.
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    438. Yaffe K, Steffens D. Epidemiology of mental health: a keystone of geriatric psychiatry. Am J Geriatr Psychiatry. 2006 Jun; 14(6):477-9. PMID: 16731715.
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    439. Barton C, Yaffe K. Reducing neuroleptic use in long-term-care settings. Lancet Neurol. 2006 Jun; 5(6):469-70. PMID: 16713916.
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    440. Hou CE, Yaffe K, Pérez-Stable EJ, Miller BL. Frequency of dementia etiologies in four ethnic groups. Dement Geriatr Cogn Disord. 2006; 22(1):42-7. PMID: 16682792.
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    442. Sink KM, Covinsky KE, Barnes DE, Newcomer RJ, Yaffe K. Caregiver characteristics are associated with neuropsychiatric symptoms of dementia. J Am Geriatr Soc. 2006 May; 54(5):796-803. PMID: 16696746.
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    443. Pope SK, Kritchevsky SB, Ambrosone C, Yaffe K, Tylavsky F, Simonsick EM, Rosano C, Stewart S, Harris T. Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition Study. Am J Epidemiol. 2006 Jun 15; 163(12):1084-90. PMID: 16641309.
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    444. Blackwell T, Yaffe K, Ancoli-Israel S, Schneider JL, Cauley JA, Hillier TA, Fink HA, Stone KL. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2006 Apr; 61(4):405-10. PMID: 16611709.
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    445. Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, Ezekiel F, Miller BL, Jagust WJ, Weiner MW. Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2006 Apr-Jun; 20(2):77-85. PMID: 16772742; PMCID: PMC1820860.
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    447. Hendrie HC, Albert MS, Butters MA, Gao S, Knopman DS, Launer LJ, Yaffe K, Cuthbert BN, Edwards E, Wagster MV. The NIH Cognitive and Emotional Health Project. Report of the Critical Evaluation Study Committee. Alzheimers Dement. 2006 Jan; 2(1):12-32. PMID: 19595852.
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    448. Lu PH, Masterman DA, Mulnard R, Cotman C, Miller B, Yaffe K, Reback E, Porter V, Swerdloff R, Cummings JL. Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch Neurol. 2006 Feb; 63(2):177-85. PMID: 16344336.
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    450. Yaffe K. Research and care of patients with dementia: moving beyond memory loss. Am J Geriatr Psychiatry. 2005 Nov; 13(11):921-5. PMID: 16286434.
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    451. Barton C, Miller B, Yaffe K. Improved evaluation and management of cognitive impairment: results of a comprehensive intervention in long-term care. J Am Med Dir Assoc. 2006 Feb; 7(2):84-9. PMID: 16461249.
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    452. Sands LP, Landefeld CS, Ayers SM, Yaffe K, Palmer R, Fortinsky R, Counsell SR, Covinsky KE. Disparities between black and white patients in functional improvement after hospitalization for an acute illness. J Am Geriatr Soc. 2005 Oct; 53(10):1811-6. PMID: 16181184.
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    453. Roberson ED, Hesse JH, Rose KD, Slama H, Johnson JK, Yaffe K, Forman MS, Miller CA, Trojanowski JQ, Kramer JH, Miller BL. Frontotemporal dementia progresses to death faster than Alzheimer disease. Neurology. 2005 Sep 13; 65(5):719-25. PMID: 16157905.
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    456. Mehta KM, Yin M, Resendez C, Yaffe K. Ethnic differences in acetylcholinesterase inhibitor use for Alzheimer disease. Neurology. 2005 Jul 12; 65(1):159-62. PMID: 16009909; PMCID: PMC2830864.
    457. Elkins JS, Yaffe K, Cauley JA, Fink HA, Hillier TA, Johnston SC. Pre-existing hypertension and the impact of stroke on cognitive function. Ann Neurol. 2005 Jul; 58(1):68-74. PMID: 15984027.
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    458. Elkins JS, Knopman DS, Yaffe K, Johnston SC. Cognitive function predicts first-time stroke and heart disease. Neurology. 2005 May 24; 64(10):1750-5. PMID: 15911803.
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    459. Kurella M, Chertow GM, Fried LF, Cummings SR, Harris T, Simonsick E, Satterfield S, Ayonayon H, Yaffe K. Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. J Am Soc Nephrol. 2005 Jul; 16(7):2127-33. PMID: 15888561.
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    460. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP, Yaffe K. Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ. 2005 Jun 11; 330(7504):1360. PMID: 15863436; PMCID: PMC558283.
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    462. Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA. 2005 Feb 02; 293(5):596-608. PMID: 15687315.
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    463. Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, Wolkowitz OM, Jagust WJ, Chui HC, Miller BL, Yaffe K, Weiner MW. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients. Neurology. 2005 Jan 25; 64(2):282-9. PMID: 15668426; PMCID: PMC1851679.
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    465. Otte C, Hart S, Neylan TC, Marmar CR, Yaffe K, Mohr DC. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology. 2005 Jan; 30(1):80-91. PMID: 15358445.
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    466. Kurella M, Yaffe K, Shlipak MG, Wenger NK, Chertow GM. Chronic kidney disease and cognitive impairment in menopausal women. Am J Kidney Dis. 2005 Jan; 45(1):66-76. PMID: 15696445.
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    469. Lin MY, Gutierrez PR, Stone KL, Yaffe K, Ensrud KE, Fink HA, Sarkisian CA, Coleman AL, Mangione CM. Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women. J Am Geriatr Soc. 2004 Dec; 52(12):1996-2002. PMID: 15571533.
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    473. Modelska K, Litwack S, Ewing SK, Yaffe K. Endogenous estrogen levels affect sexual function in elderly post-menopausal women. Maturitas. 2004 Oct 15; 49(2):124-33. PMID: 15474756.
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    474. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. PMID: 15592130; PMCID: PMC1820853.
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    476. Sink KM, Covinsky KE, Newcomer R, Yaffe K. Ethnic differences in the prevalence and pattern of dementia-related behaviors. J Am Geriatr Soc. 2004 Aug; 52(8):1277-83. PMID: 15271114.
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    477. Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med. 2004 Jun 28; 164(12):1327-33. PMID: 15226167.
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    478. Edwards ER, Lindquist K, Yaffe K. Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics. Neurology. 2004 May 11; 62(9):1639-42. PMID: 15136703.
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    479. Sands LP, Ferreira P, Stewart AL, Brod M, Yaffe K. What explains differences between dementia patients' and their caregivers' ratings of patients' quality of life? Am J Geriatr Psychiatry. 2004 May-Jun; 12(3):272-80. PMID: 15126228.
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    480. Yaffe K. Testosterone and the brain: uncharted territory. Lancet Neurol. 2004 May; 3(5):270. PMID: 15099540.
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    482. Covinsky KE, Yaffe K. Dementia, prognosis, and the needs of patients and caregivers. Ann Intern Med. 2004 Apr 06; 140(7):573-4. PMID: 15068987.
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    483. Barnes DE, Tager IB, Satariano WA, Yaffe K. The relationship between literacy and cognition in well-educated elders. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):390-5. PMID: 15071084.
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    485. Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR, Mungas D, Yaffe K, Chui HC, Weiner MW. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology. 2004 Feb 10; 62(3):422-7. PMID: 14872024; PMCID: PMC1820859.
    486. Covinsky KE, Newcomer R, Fox P, Wood J, Sands L, Dane K, Yaffe K. Patient and caregiver characteristics associated with depression in caregivers of patients with dementia. J Gen Intern Med. 2003 Dec; 18(12):1006-14. PMID: 14687259; PMCID: PMC1494966.
    487. Yaffe K, Edwards ER, Lui LY, Zmuda JM, Ferrell RE, Cauley JA. Androgen receptor CAG repeat polymorphism is associated with cognitive function in older men. Biol Psychiatry. 2003 Nov 01; 54(9):943-6. PMID: 14573323.
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    489. Penninx BW, Kritchevsky SB, Yaffe K, Newman AB, Simonsick EM, Rubin S, Ferrucci L, Harris T, Pahor M. Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry. 2003 Sep 01; 54(5):566-72. PMID: 12946885.
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    490. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Jagust WJ, Chui HC, Kramer JH, Reed BR, Miller BL, Yaffe K, Weiner MW. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology. 2003 Aug 12; 61(3):358-64. PMID: 12913198; PMCID: PMC1820863.
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    492. Yaffe K. Hormone therapy and the brain: déjà vu all over again? JAMA. 2003 May 28; 289(20):2717-9. PMID: 12771119.
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    493. Newcomer R, Covinsky KE, Clay T, Yaffe K. Predicting 12-month mortality for persons with dementia. J Gerontol B Psychol Sci Soc Sci. 2003 May; 58(3):S187-98. PMID: 12730320.
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    499. Barton C, Miller B, Yaffe K. Evaluation of the diagnosis and management of cognitive impairment in long-term care. Alzheimer Dis Assoc Disord. 2003 Apr-Jun; 17(2):72-6. PMID: 12794383.
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    506. Grundman M, Jack CR, Petersen RC, Kim HT, Taylor C, Datvian M, Weiner MF, DeCarli C, DeKosky ST, van Dyck C, Darvesh S, Yaffe K, Kaye J, Ferris SH, Thomas RG, Thal LJ. Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment. J Mol Neurosci. 2003; 20(3):241-8. PMID: 14501003.
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    514. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Kramer J, Jagust W, Miller B, Wolkowitz OM, Yaffe K, Weiner MW. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology. 2002 Mar 26; 58(6):928-35. PMID: 11914410; PMCID: PMC1851674.
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    518. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 Oct; 71(4):441-7. PMID: 11561025.
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    520. Yaffe K, Krueger K, Sarkar S, Grady D, Barrett-Connor E, Cox DA, Nickelsen T. Cognitive function in postmenopausal women treated with raloxifene. N Engl J Med. 2001 Apr 19; 344(16):1207-13. PMID: 11309635.
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    523. Kusdra L, Rempel H, Yaffe K, Pulliam L. Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease. Immunobiology. 2000 May; 202(1):26-33. PMID: 10879686.
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    524. Covinsky KE, Fuller JD, Yaffe K, Johnston CB, Hamel MB, Lynn J, Teno JM, Phillips RS. Communication and decision-making in seriously ill patients: findings of the SUPPORT project. The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Am Geriatr Soc. 2000 May; 48(5 Suppl):S187-93. PMID: 10809474.
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    525. Yaffe K, Browner W, Cauley J, Launer L, Harris T. Association between bone mineral density and cognitive decline in older women. J Am Geriatr Soc. 1999 Oct; 47(10):1176-82. PMID: 10522949.
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    527. Yaffe K, Yaffe SJ. Commentary: Long-term cognitive effects of drugs used during labor. West J Med. 1999 May; 170(5):262. PMID: 18751141.
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    532. Yaffe K, Ferriero D, Barkovich AJ, Rowley H. Reversible MRI abnormalities following seizures. Neurology. 1995 Jan; 45(1):104-8. PMID: 7824097.
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    533. Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology. 1993 May; 43(5):895-900. PMID: 8492944.
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