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Kristine Yaffe, MD

TitleProfessor of Psychiatry, Neurology and Epidemiology
InstitutionUniversity of California San Francisco
DepartmentPsychiatry
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 3985
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    Other Positions
    TitleRoy and Marie Scola Endowed Chair

    TitleVice Chair of Research in Psychiatry


    Collapse Biography 
    Collapse Education and Training
    Yale University BSBiology-Psychology
    University of Pennsylvania M.D.School of Medicine
    University of California, San FranciscoResidency Neurology and Psychiatry
    University of California, San FranciscoFellowship Geriatric Psychiatry
    University of California, San FranciscoFellowshipClinical Epidemiology
    Collapse Awards and Honors
    American Academy of Neurology2017Potamkin Prize for Dementia Research
    American College of Psychiatrists 2015Research Award in Geriatric Psychiatry
    Thomson Reuters2014World’s Most Influential Scientific Minds
    American Association for Geriatric Psychiatry2014Distinguished Scientist Award
    UCSF2013Faculty Research Award in Clinical Science
    Johns Hopkins Division of Geriatric Psychiatry and Neuropsychiatry2013John Mackey Award for Excellence in Dementia Care
    International Conference on Alzheimer’s Disease and Related Disorders2011  - 2013Chair, Scientific Planning Committee
    UCSF Department of Psychiatry2010Royer Award for Academic Excellence in Psychiatry
    American Academy of Neurology2005Research Award in Geriatrics

    Collapse Overview 
    Collapse Overview
    Kristine Yaffe, MD, is a Professor of Psychiatry, Neurology and Epidemiology, the Roy and Marie Scola Endowed Chair and Vice Chair of Research in Psychiatry at UCSF. Dr. Yaffe is dually trained in neurology and psychiatry and completed postdoctoral training in epidemiology and geriatric psychiatry, all at UCSF. In addition to her positions at UCSF, Dr. Yaffe is the Chief of Neuropsychiatry and the Director of the Memory Disorders Clinic at the San Francisco Veteran’s Affairs Medical Center. In her research, clinical work, and mentoring, she has worked towards improving the care of patients with cognitive disorders and other geriatric neuropsychiatric conditions.

    Dr. Yaffe's research has focused on the predictors and outcomes of cognitive decline and dementia in older adults. She is particularly interested in identifying novel risk factors for cognitive impairment that may lead to strategies to prevent cognitive decline. Dr. Yaffe is the principal investigator of 8 NIH grants as well as several other grants, and she has published over 450 peer-reviewed articles (H-index=118) in numerous prestigious journals including the Lancet, BMJ, JAMA, and NEJM. Dr. Yaffe also edited a book published by Oxford Press, “Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain.” In 2014, she was recognized as one of Thomas Reuters World’s Most Influential Scientific Minds and honored by the American Association for Geriatric Psychiatry with the Distinguished Scientist Award. Dr. Yaffe was recently awarded the prestigious Potamkin Prize by the American Academy of Neurology.


    Collapse Research 
    Collapse Research Activities and Funding
    Genetics, comorbidities, and ethnicity: Effects of TBI on Dementia
    Department of Army W81XWH-18-1-0692Sep 30, 2018 - Sep 29, 2021
    Role: Multiple Principal Investigator
    An Alzheimer's Blood Test for Primary Care
    NIH/NIA R01AG058537Jun 1, 2018 - May 31, 2021
    Role: Multiple Principal Investigator
    Connection Between Depressive Symptoms and Dementia: When Best to Intervene?
    Alzheimer’s Drug Discovery Foundation Jun 1, 2018 - May 31, 2020
    Role: Multiple Principal Investigator
    Leveraging New Data on Cognitive Aging & Dementia from Around the World
    Global Brain Health Institute Jun 1, 2018 - May 31, 2020
    Role: Multiple Principal Investigator
    Paul B. Beeson Emerging Leaders Career Development Awards in Aging Annual Meeting
    NIH/NIA R13AG058415Sep 15, 2017 - May 31, 2022
    Role: Multiple Principal Investigator
    Multidomain Alzheimers Risk Reduction Study (MARRS) Pilot
    NIH/NIA R01AG057508Sep 15, 2017 - Apr 30, 2021
    Role: Multiple Principal Investigator
    Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans
    NIH/NIA R01AG054073Sep 1, 2017 - May 31, 2022
    Role: Multiple Principal Investigator
    Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment
    NIH/NIA RF1AG054443May 1, 2017 - Apr 30, 2021
    Role: Multiple Principal Investigator
    Risk and Resiliency for Dementia: Comparison of Male and Female Veterans
    Department of Defense W81XWH1610507Aug 15, 2016 - Aug 14, 2019
    Role: Principal Investigator
    Chronic Effects of Neurotrauma Consortium: Epidemiology Project
    Department of Defense/VA W81XWH-12-PHTBI-CENCFeb 1, 2015 - Sep 29, 2019
    Role: Principal Investigator
    Determinants of Midlife & Longitudinal Change in Cognitive Function: CARDIA Study
    NIH/NHLBI R01HL122658Dec 1, 2014 - Nov 30, 2018
    Role: Multiple Principal Investigator
    Blood biomarker profile of TBI-associated cognitive impairment
    Department of Defense W81XWH1420137Sep 30, 2014 - Sep 29, 2019
    Role: Principal Investigator
    Long Term Depressive Symptom Course &Adverse Health Outcomes among Older Women
    NIH R01MH086498Mar 4, 2010 - Feb 28, 2014
    Role: Principal Investigator
    Predictors of cognitive aging across the lifecourse
    NIH/NIA K24AG031155Sep 30, 2007 - Nov 30, 2020
    Role: Principal Investigator
    Cognitive Decline in Chronic Renal Insufficiency
    NIH R01DK069406Sep 15, 2005 - May 31, 2015
    Role: Multiple Principal Investigator
    Metabolic Syndrome and Cognitive Impairment
    NIH/NIDDK R21DK070713Sep 1, 2005 - Aug 31, 2007
    Role: Principal Investigator
    Changes in Sleep and Cognition in Older Women
    NIH/NIA R01AG026720Jul 1, 2005 - Mar 31, 2017
    Role: Multiple Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH/NIA P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Sex Hormones, Related Polymorphisms &Cognitive Decline
    NIH/NIA R01AG021918Sep 30, 2003 - Aug 31, 2009
    Role: Principal Investigator
    Frontotemporal Dementia: Genes, Images, and Emotions
    NIH/NIA P01AG019724Jul 1, 2001 - May 31, 2022
    Role: Co-Investigator
    ESTROGEN COMPOUNDS, COGNITION &DEMENTIA IN OLDER WOMEN
    NIH/NIA K23AG000888Sep 30, 1998 - Feb 28, 2005
    Role: Principal Investigator
    ESTROGEN COMPOUNDS, COGNITION &DEMENTIA IN OLDER WOMEN
    NIH/NIA K08AG000888Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Study of Osteoporotic Fractures
    NIH/NIA R01AG005407Feb 1, 1986 - May 31, 2017
    Role: Multiple Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Whitson HE, Cronin-Golomb A, Cruickshanks KJ, Gilmore GC, Owsley C, Peelle JE, Recanzone G, Sharma A, Swenor B, Yaffe K, Lin FR. American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory Impairment and Cognitive Decline in Older Adults. J Am Geriatr Soc. 2018 Sep 24. PMID: 30248173.
      View in: PubMed
    2. LeBlanc ES, Rizzo JH, Pedula KL, Yaffe K, Ensrud KE, Cauley JA, Cawthon PM, Cummings SR, Hillier TA. Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death. J Am Geriatr Soc. 2018 Aug 27. PMID: 30151825.
      View in: PubMed
    3. Huang X, Meyers K, Liu X, Li X, Zhang T, Xia W, Hou J, Song A, He H, Li C, He S, Cai W, Zhong H, Huang C, Liu S, Wang H, Ling X, Ma P, Ye R, Xiao G, Li T, Ding D, Yaffe K, Chen H, Chen Y, Wu H. The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China. Front Psychiatry. 2018; 9:384. PMID: 30197608.
      View in: PubMed
    4. Rogers-Soeder TS, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Cauley JA, Ensrud KE, Paudel M, Barrett-Connor E, LeBlanc E, Stone K, Lane NE, Tranah G. Rest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc. 2018 Aug 23. PMID: 30136716.
      View in: PubMed
    5. Lee JS, Kim S, Yoo H, Park S, Jang YK, Kim HJ, Kim KW, Kim Y, Jang H, Park KC, Yaffe K, Yang JJ, Lee JM, Na DL, Seo SW. Trajectories of Physiological Brain Aging and Related Factors in People Aged from 20 to over-80. J Alzheimers Dis. 2018 Aug 20. PMID: 30149442.
      View in: PubMed
    6. Byers AL, Lui LY, Vittinghoff E, Covinsky KE, Ensrud KE, Taylor B, Yaffe K. Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc. 2018 Aug 09. PMID: 30094824.
      View in: PubMed
    7. Tranah GJ, Katzman SM, Lauterjung K, Yaffe K, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.3243A?>?G heteroplasmy affects multiple aging phenotypes and risk of mortality. Sci Rep. 2018 Aug 08; 8(1):11887. PMID: 30089816.
      View in: PubMed
    8. Bayen E, Possin KL, Chen Y, Cleret de Langavant L, Yaffe K. Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome. JAMA Neurol. 2018 Jul 22. PMID: 30032260.
      View in: PubMed
    9. Feng L, Langsetmo L, Yaffe K, Sun Y, Fink HA, Shikany JM, Leung PC, Lane NE, Cauley JA. No Effects of Black Tea on Cognitive Decline Among Older US Men: A Prospective Cohort Study. J Alzheimers Dis. 2018 Jul 17. PMID: 30040715.
      View in: PubMed
    10. Cleret de Langavant L, Bayen E, Yaffe K. Unsupervised Machine Learning to Identify High Likelihood of Dementia in Population-Based Surveys: Development and Validation Study. J Med Internet Res. 2018 Jul 09; 20(7):e10493. PMID: 29986849.
      View in: PubMed
    11. Kaup AR, Xia F, Launer LJ, Sidney S, Nasrallah I, Erus G, Allen N, Yaffe K. Occupational cognitive complexity in earlier adulthood is associated with brain structure and cognitive health in midlife: The CARDIA study. Neuropsychology. 2018 Jul 09. PMID: 29985017.
      View in: PubMed
    12. Bertenthal D, Yaffe K, Barnes DE, Byers AL, Gibson CJ, Seal KH. Do postconcussive symptoms from traumatic brain injury in combat veterans predict risk for receiving opioid therapy for chronic pain? Brain Inj. 2018 Jul 09; 1-9. PMID: 29985653.
      View in: PubMed
    13. Tranah GJ, Maglione JE, Yaffe K, Katzman SM, Manini TM, Kritchevsky S, Newman AB, Harris TB, Cummings SR. Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly. Int J Geriatr Psychiatry. 2018 Jul 08. PMID: 29984425.
      View in: PubMed
    14. Kaup A, Toomey R, Bangen KJ, Delano-Wood L, Yaffe KC, Panizzon MS, Lyons MJ, Franz CE, Kremen WS. The Interactive Effect of Traumatic Brain Injury and Psychiatric Symptoms on Cognition Among Late Middle-Aged Men: Findings from the Vietnam Era Twin Study of Aging (VETSA). J Neurotrauma. 2018 Jul 06. PMID: 29978738.
      View in: PubMed
    15. Casaletto KB, Staffaroni AM, Elahi F, Fox E, Crittenden PA, You M, Neuhaus J, Glymour M, Bettcher BM, Yaffe K, Kramer JH. Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults. Am J Geriatr Psychiatry. 2018 Jun 18. PMID: 30017239.
      View in: PubMed
    16. Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K. Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol. 2018 Jun 04. PMID: 29873737.
      View in: PubMed
    17. Barnes DE, Byers AL, Gardner RC, Seal KH, Boscardin WJ, Yaffe K. Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans. JAMA Neurol. 2018 May 07. PMID: 29801145.
      View in: PubMed
    18. Diem SJ, Vo TN, Langsetmo L, Schousboe JT, Yaffe K, Ensrud KE. Impact of Competing Risk of Mortality on Association of Cognitive Impairment with Risk of Hip Fracture in Older Women. J Bone Miner Res. 2018 May 07. PMID: 29734471.
      View in: PubMed
    19. Duarte S, Hoang T, Ewing SK, Cawthon PM, Cummings S, Stone KL, Cauley JA, Bauer DC, Hillier TA, Yaffe K. Glycated peptide levels are associated with cognitive decline among non-diabetic older women. J Gerontol A Biol Sci Med Sci. 2018 May 07. PMID: 29741593.
      View in: PubMed
    20. Harhay MN, Xie D, Zhang X, Hsu CY, Vittinghoff E, Go AS, Sozio SM, Blumenthal J, Seliger S, Chen J, Deo R, Dobre M, Akkina S, Reese PP, Lash JP, Yaffe K, Tamura MK. Cognitive Impairment in Non-Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2018 May 02. PMID: 29728316.
      View in: PubMed
    21. Ensrud KE, Kats AM, Schousboe JT, Taylor BC, Cawthon PM, Hillier TA, Yaffe K, Cummings SR, Cauley JA, Langsetmo L. Frailty Phenotype and Healthcare Costs and Utilization in Older Women. J Am Geriatr Soc. 2018 Apr 23. PMID: 29684237.
      View in: PubMed
    22. Gardner RC, Byers AL, Barnes DE, Li Y, Boscardin J, Yaffe K. Mild TBI and risk of Parkinson disease: A Chronic Effects of Neurotrauma Consortium Study. Neurology. 2018 May 15; 90(20):e1771-e1779. PMID: 29669907.
      View in: PubMed
    23. Seal KH, Bertenthal D, Barnes DE, Byers AL, Gibson CJ, Yaffe K. Traumatic Brain Injury and Receipt of Prescription Opioid Therapy for Chronic Pain in Iraq and Afghanistan Veterans: Do Clinical Practice Guidelines Matter? J Pain. 2018 Mar 26. PMID: 29597083.
      View in: PubMed
    24. Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K. Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol. 2018 Mar 08. PMID: 29518257.
      View in: PubMed
    25. Kilpatrick L, Houston DK, Wilson VK, Lovato J, Ayonayon HN, Cauley JA, Harris T, Simonsick EM, Yaffe K, Kritchevsky SB, Sink KM. Low 25-Hydroxyvitamin D Concentrations and Risk of Incident Cognitive Impairment in Black and White Older Adults: The Health ABC Study. J Nutr Gerontol Geriatr. 2018 Jan-Mar; 37(1):1-13. PMID: 29505349.
      View in: PubMed
    26. Djonlagic I, Aeschbach D, Harrison SL, Dean D, Yaffe K, Ancoli-Israel S, Stone K, Redline S. Associations between quantitative sleep EEG and subsequent cognitive decline in older women. J Sleep Res. 2018 Mar 05. PMID: 29508460.
      View in: PubMed
    27. Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K. Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women. J Gerontol A Biol Sci Med Sci. 2018 Mar 02; 73(3):374-379. PMID: 28329031.
      View in: PubMed
    28. Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K. Corrigendum to: "Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women". J Gerontol A Biol Sci Med Sci. 2018 Mar 02; 73(3):419. PMID: 29155930.
      View in: PubMed
    29. Nowak KL, Yaffe K, Orwoll ES, Ix JH, You Z, Barrett-Connor E, Hoffman AR, Chonchol M. Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol. 2018 Mar 07; 13(3):366-374. PMID: 29439092.
      View in: PubMed
    30. Yaffe K. Modifiable Risk Factors and Prevention of Dementia: What Is the Latest Evidence? JAMA Intern Med. 2018 Feb 01; 178(2):281-282. PMID: 29255907.
      View in: PubMed
    31. Tranah GJ, Yaffe K, Nievergelt CM, Parimi N, Glymour MM, Ensrud KE, Cauley JA, Ancoli-Israel S, Mariani S, Redline S, Stone KL. APOEe4 and slow wave sleep in older adults. PLoS One. 2018; 13(1):e0191281. PMID: 29370207.
      View in: PubMed
    32. Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M. Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol. 2018; 47(1):57-65. PMID: 29393090.
      View in: PubMed
    33. Bonham LW, Evans DS, Liu Y, Cummings SR, Yaffe K, Yokoyama JS. Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen. 2018 May; 33(3):153-165. PMID: 29338302.
      View in: PubMed
    34. Haight T, Bryan RN, Meirelles O, Tracy R, Fornage M, Richard M, Nasrallah I, Yaffe K, Jacobs DR, Lewis C, Schreiner P, Sidney S, Davatzikos C, Launer LJ. Associations of plasma clusterin and Alzheimer's disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study. PLoS One. 2018; 13(1):e0190478. PMID: 29324756.
      View in: PubMed
    35. Freimer D, Yaffe K. Author response: Olfaction and risk of dementia in a biracial cohort of older adults. Neurology. 2018 Jan 09; 90(2):99. PMID: 29311371.
      View in: PubMed
    36. Rosso AL, Bohnen NI, Launer LJ, Aizenstein HJ, Yaffe K, Rosano C. Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Neurology. 2018 Jan 16; 90(3):e223-e229. PMID: 29247072.
      View in: PubMed
    37. Leng Y, Diem SJ, Stone KL, Yaffe K. Antidepressant Use and Cognitive Outcomes in Very Old Women. J Gerontol A Biol Sci Med Sci. 2017 Dec 12. PMID: 29244058.
      View in: PubMed
    38. Suemoto CK, Grinberg LT, Leite REP, Ferretti-Rebustini REL, Jacob-Filho W, Yaffe K, Nitrini R, Pasqualucci CA. Morphometric measurements of extracranial and intracranial atherosclerotic disease: A population-based autopsy study. Atherosclerosis. 2018 Mar; 270:218-223. PMID: 29254693.
      View in: PubMed
    39. Zeki Al Hazzouri A, Elfassy T, Carnethon MR, Lloyd-Jones DM, Yaffe K. Heart Rate Variability and Cognitive Function In Middle-Age Adults: The Coronary Artery Risk Development in Young Adults. Am J Hypertens. 2017 Dec 08; 31(1):27-34. PMID: 28985245.
      View in: PubMed
    40. Mariani S, Tarokh L, Djonlagic I, Cade BE, Morrical MG, Yaffe K, Stone KL, Loparo KA, Purcell SM, Redline S, Aeschbach D. Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med. 2018 Jul; 47:126-136. PMID: 29803181.
      View in: PubMed
    41. Deckers K, Camerino I, van Boxtel MPJ, Verhey FRJ, Irving K, Brayne C, Kivipelto M, Starr JM, Yaffe K, de Leeuw PW, Köhler S. Author response: Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies. Neurology. 2017 Nov 21; 89(21):2214-2215. PMID: 29158301.
      View in: PubMed
    42. Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Bragge P, Brazinova A, Büki A, Chesnut RM, Citerio G, Coburn M, Cooper DJ, Crowder AT, Czeiter E, Czosnyka M, Diaz-Arrastia R, Dreier JP, Duhaime AC, Ercole A, van Essen TA, Feigin VL, Gao G, Giacino J, Gonzalez-Lara LE, Gruen RL, Gupta D, Hartings JA, Hill S, Jiang JY, Ketharanathan N, Kompanje EJO, Lanyon L, Laureys S, Lecky F, Levin H, Lingsma HF, Maegele M, Majdan M, Manley G, Marsteller J, Mascia L, McFadyen C, Mondello S, Newcombe V, Palotie A, Parizel PM, Peul W, Piercy J, Polinder S, Puybasset L, Rasmussen TE, Rossaint R, Smielewski P, Söderberg J, Stanworth SJ, Stein MB, von Steinbüchel N, Stewart W, Steyerberg EW, Stocchetti N, Synnot A, Te Ao B, Tenovuo O, Theadom A, Tibboel D, Videtta W, Wang KKW, Williams WH, Wilson L, Yaffe K. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Dec; 16(12):987-1048. PMID: 29122524.
      View in: PubMed
    43. Middleton LE, Ventura MI, Santos-Modesitt W, Poelke G, Yaffe K, Barnes DE. The Mental Activity and eXercise (MAX) trial: Effects on physical function and quality of life among older adults with cognitive complaints. Contemp Clin Trials. 2018 Jan; 64:161-166. PMID: 29066293.
      View in: PubMed
    44. Leng Y, McEvoy CT, Allen IE, Yaffe K. Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis. JAMA Neurol. 2017 Oct 01; 74(10):1237-1245. PMID: 28846764.
      View in: PubMed
    45. Hajjar I, Rosenberger KJ, Kulshreshtha A, Ayonayon HN, Yaffe K, Goldstein FC. Association of JNC-8 and SPRINT Systolic Blood Pressure Levels With Cognitive Function and Related Racial Disparity. JAMA Neurol. 2017 Oct 01; 74(10):1199-1205. PMID: 28828478.
      View in: PubMed
    46. Casaletto KB, Elahi FM, Bettcher BM, Neuhaus J, Bendlin BB, Asthana S, Johnson SC, Yaffe K, Carlsson C, Blennow K, Zetterberg H, Kramer JH. Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers. Neurology. 2017 Oct 24; 89(17):1782-1788. PMID: 28939668.
      View in: PubMed
    47. Aubert CE, Bauer DC, da Costa BR, Feller M, Rieben C, Simonsick EM, Yaffe K, Rodondi N. The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study. Clin Endocrinol (Oxf). 2017 Nov; 87(5):617-626. PMID: 28850708.
      View in: PubMed
    48. Gorelick PB, Furie KL, Iadecola C, Smith EE, Waddy SP, Lloyd-Jones DM, Bae HJ, Bauman MA, Dichgans M, Duncan PW, Girgus M, Howard VJ, Lazar RM, Seshadri S, Testai FD, van Gaal S, Yaffe K, Wasiak H, Zerna C. Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association. Stroke. 2017 10; 48(10):e284-e303. PMID: 28883125.
      View in: PubMed
    49. Cruz-Almeida Y, Rosso A, Marcum Z, Harris T, Newman AB, Nevitt M, Satterfield S, Yaffe K, Rosano C. Associations of Musculoskeletal Pain With Mobility in Older Adults: Potential Cerebral Mechanisms. J Gerontol A Biol Sci Med Sci. 2017 Sep 01; 72(9):1270-1276. PMID: 28505228.
      View in: PubMed
    50. Gardner RC, Peltz CB, Kenney K, Covinsky KE, Diaz-Arrastia R, Yaffe K. Remote Traumatic Brain Injury Is Associated with Motor Dysfunction in Older Military Veterans. J Gerontol A Biol Sci Med Sci. 2017 Sep 01; 72(9):1233-1238. PMID: 28329183.
      View in: PubMed
    51. Brown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR. Biological Age, Not Chronological Age, is Associated with Late Life Depression. J Gerontol A Biol Sci Med Sci. 2017 Aug 24. PMID: 28958059.
      View in: PubMed
    52. Spira AP, Stone KL, Redline S, Ensrud KE, Ancoli-Israel S, Cauley JA, Yaffe K. Actigraphic Sleep Duration and Fragmentation in Older Women: Associations With Performance Across Cognitive Domains. Sleep. 2017 Aug 01; 40(8). PMID: 28472447.
      View in: PubMed
    53. Kaup AR, Yaffe K. Reassuring News About Football and Cognitive Decline?: Not So Fast. JAMA Neurol. 2017 Aug 01; 74(8):898-899. PMID: 28672374.
      View in: PubMed
    54. Leng X, Espeland MA, Manson JE, Stefanick ML, Gower EW, Hayden KM, Limacher MC, Vaughan L, Robinson J, Wallace R, Wassertheil-Smoller S, Yaffe K, Shumaker SA. Cognitive Function and Changes in Cognitive Function as Predictors of Incident Cardiovascular Disease: The Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2017 Jul 25. PMID: 28977360.
      View in: PubMed
    55. Rosso AL, Verghese J, Metti AL, Boudreau RM, Aizenstein HJ, Kritchevsky S, Harris T, Yaffe K, Satterfield S, Studenski S, Rosano C. Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate. Neurology. 2017 Jul 25; 89(4):336-342. PMID: 28659421.
      View in: PubMed
    56. Byers AL, Lai AX, Nelson C, Yaffe K. Predictors of Mental Health Services Use Across the Life Course among Racially-Ethnically Diverse Adults. Am J Geriatr Psychiatry. 2017 Nov; 25(11):1213-1222. PMID: 28774787.
      View in: PubMed
    57. Ensrud KE, Lui LY, Langsetmo L, Vo TN, Taylor BC, Cawthon PM, Kilgore ML, McCulloch CE, Cauley JA, Stefanick ML, Yaffe K, Orwoll ES, Schousboe JT. Effects of Mobility and Multimorbidity on Inpatient and Post-Acute Health Care Utilization. J Gerontol A Biol Sci Med Sci. 2017 Jun 22. PMID: 28645202.
      View in: PubMed
    58. Metti AL, Rosano C, Boudreau R, Massa R, Yaffe K, Satterfield S, Harris T, Rosso AL. Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults. J Am Geriatr Soc. 2017 Sep; 65(9):2016-2022. PMID: 28640434.
      View in: PubMed
    59. Best JR, Rosano C, Aizenstein HJ, Tian Q, Boudreau RM, Ayonayon HN, Satterfield S, Simonsick EM, Studenski S, Yaffe K, Liu-Ambrose T. Long-term changes in time spent walking and subsequent cognitive and structural brain changes in older adults. Neurobiol Aging. 2017 Sep; 57:153-161. PMID: 28648916.
      View in: PubMed
    60. Yoon CY, Steffen LM, Gross MD, Launer LJ, Odegaard A, Reiner A, Sanchez O, Yaffe K, Sidney S, Jacobs DR. Circulating Cellular Adhesion Molecules and Cognitive Function: The Coronary Artery Risk Development in Young Adults Study. Front Cardiovasc Med. 2017; 4:37. PMID: 28596958.
      View in: PubMed
    61. Deal JA, Betz J, Yaffe K, Harris T, Purchase-Helzner E, Satterfield S, Pratt S, Govil N, Simonsick EM, Lin FR. Hearing Impairment and Incident Dementia and Cognitive Decline in Older Adults: The Health ABC Study. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):703-709. PMID: 27071780.
      View in: PubMed
    62. Seal KH, Bertenthal D, Barnes DE, Byers AL, Strigo I, Yaffe K. Association of Traumatic Brain Injury With Chronic Pain in Iraq and Afghanistan Veterans: Effect of Comorbid Mental Health Conditions. Arch Phys Med Rehabil. 2017 08; 98(8):1636-1645. PMID: 28455190.
      View in: PubMed
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    391. Elkins JS, Whitmer RA, Sidney S, Sorel M, Yaffe K, Johnston SC. Midlife obesity and long-term risk of nursing home admission. Obesity (Silver Spring). 2006 Aug; 14(8):1472-8. PMID: 16988091.
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    403. Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006 Mar; 63(3):273-9. PMID: 16520432.
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    404. Hendrie HC, Albert MS, Butters MA, Gao S, Knopman DS, Launer LJ, Yaffe K, Cuthbert BN, Edwards E, Wagster MV. The NIH Cognitive and Emotional Health Project. Report of the Critical Evaluation Study Committee. Alzheimers Dement. 2006 Jan; 2(1):12-32. PMID: 19595852.
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    406. Newcomer RJ, Clay TH, Yaffe K, Covinsky KE. Mortality risk and prospective medicare expenditures for persons with dementia. J Am Geriatr Soc. 2005 Nov; 53(11):2001-6. PMID: 16274386.
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    407. Yaffe K. Research and care of patients with dementia: moving beyond memory loss. Am J Geriatr Psychiatry. 2005 Nov; 13(11):921-5. PMID: 16286434.
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    413. Elkins JS, Yaffe K, Cauley JA, Fink HA, Hillier TA, Johnston SC. Pre-existing hypertension and the impact of stroke on cognitive function. Ann Neurol. 2005 Jul; 58(1):68-74. PMID: 15984027.
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    420. Otte C, Hart S, Neylan TC, Marmar CR, Yaffe K, Mohr DC. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology. 2005 Jan; 30(1):80-91. PMID: 15358445.
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    421. Kurella M, Yaffe K, Shlipak MG, Wenger NK, Chertow GM. Chronic kidney disease and cognitive impairment in menopausal women. Am J Kidney Dis. 2005 Jan; 45(1):66-76. PMID: 15696445.
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    422. Mehta KM, Simonsick EM, Rooks R, Newman AB, Pope SK, Rubin SM, Yaffe K. Black and white differences in cognitive function test scores: what explains the difference? J Am Geriatr Soc. 2004 Dec; 52(12):2120-7. PMID: 15571554; PMCID: PMC2939725.
    423. Kurella M, Luan J, Yaffe K, Chertow GM. Validation of the Kidney Disease Quality of Life (KDQOL) cognitive function subscale. Kidney Int. 2004 Dec; 66(6):2361-7. PMID: 15569327.
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    424. Lin MY, Gutierrez PR, Stone KL, Yaffe K, Ensrud KE, Fink HA, Sarkisian CA, Coleman AL, Mangione CM. Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women. J Am Geriatr Soc. 2004 Dec; 52(12):1996-2002. PMID: 15571533.
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    425. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004 Nov 10; 292(18):2237-42. PMID: 15536110.
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    426. Yaffe K, Clemons TE, McBee WL, Lindblad AS. Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial. Neurology. 2004 Nov 09; 63(9):1705-7. PMID: 15534261; PMCID: PMC1473037.
    427. Kurella M, Chertow GM, Luan J, Yaffe K. Cognitive impairment in chronic kidney disease. J Am Geriatr Soc. 2004 Nov; 52(11):1863-9. PMID: 15507063.
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    428. Modelska K, Litwack S, Ewing SK, Yaffe K. Endogenous estrogen levels affect sexual function in elderly post-menopausal women. Maturitas. 2004 Oct 15; 49(2):124-33. PMID: 15474756.
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    429. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. PMID: 15592130; PMCID: PMC1820853.
    430. Sink KM, Covinsky KE, Newcomer R, Yaffe K. Ethnic differences in the prevalence and pattern of dementia-related behaviors. J Am Geriatr Soc. 2004 Aug; 52(8):1277-83. PMID: 15271114.
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    431. Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med. 2004 Jun 28; 164(12):1327-33. PMID: 15226167.
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    432. Edwards ER, Lindquist K, Yaffe K. Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics. Neurology. 2004 May 11; 62(9):1639-42. PMID: 15136703.
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    433. Yaffe K. Testosterone and the brain: uncharted territory. Lancet Neurol. 2004 May; 3(5):270. PMID: 15099540.
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    434. Kurella M, Ireland C, Hlatky MA, Shlipak MG, Yaffe K, Hulley SB, Chertow GM. Physical and sexual function in women with chronic kidney disease. Am J Kidney Dis. 2004 May; 43(5):868-76. PMID: 15112178.
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    435. Sands LP, Ferreira P, Stewart AL, Brod M, Yaffe K. What explains differences between dementia patients' and their caregivers' ratings of patients' quality of life? Am J Geriatr Psychiatry. 2004 May-Jun; 12(3):272-80. PMID: 15126228.
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    436. Covinsky KE, Yaffe K. Dementia, prognosis, and the needs of patients and caregivers. Ann Intern Med. 2004 Apr 06; 140(7):573-4. PMID: 15068987.
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    437. Barnes DE, Tager IB, Satariano WA, Yaffe K. The relationship between literacy and cognition in well-educated elders. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):390-5. PMID: 15071084.
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    438. Brach JS, Simonsick EM, Kritchevsky S, Yaffe K, Newman AB. The association between physical function and lifestyle activity and exercise in the health, aging and body composition study. J Am Geriatr Soc. 2004 Apr; 52(4):502-9. PMID: 15066063.
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    439. Covinsky KE, Newcomer R, Fox P, Wood J, Sands L, Dane K, Yaffe K. Patient and caregiver characteristics associated with depression in caregivers of patients with dementia. J Gen Intern Med. 2003 Dec; 18(12):1006-14. PMID: 14687259; PMCID: PMC1494966.
    440. Yaffe K, Edwards ER, Lui LY, Zmuda JM, Ferrell RE, Cauley JA. Androgen receptor CAG repeat polymorphism is associated with cognitive function in older men. Biol Psychiatry. 2003 Nov 01; 54(9):943-6. PMID: 14573323.
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    441. Yaffe K, Edwards ER, Covinsky KE, Lui LY, Eng C. Depressive symptoms and risk of mortality in frail, community-living elderly persons. Am J Geriatr Psychiatry. 2003 Sep-Oct; 11(5):561-7. PMID: 14506090.
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    442. Penninx BW, Kritchevsky SB, Yaffe K, Newman AB, Simonsick EM, Rubin S, Ferrucci L, Harris T, Pahor M. Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry. 2003 Sep 01; 54(5):566-72. PMID: 12946885.
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    443. Yaffe K. Hormone therapy and the brain: déjà vu all over again? JAMA. 2003 May 28; 289(20):2717-9. PMID: 12771119.
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    444. Newcomer R, Covinsky KE, Clay T, Yaffe K. Predicting 12-month mortality for persons with dementia. J Gerontol B Psychol Sci Soc Sci. 2003 May; 58(3):S187-98. PMID: 12730320.
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    445. Mehta KM, Yaffe K, Langa KM, Sands L, Whooley MA, Covinsky KE. Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. J Gerontol A Biol Sci Med Sci. 2003 May; 58(5):M461-7. PMID: 12730257; PMCID: PMC2939722.
    446. Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc. 2003 Apr; 51(4):459-65. PMID: 12657064.
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    447. Covinsky KE, Eng C, Lui LY, Sands LP, Yaffe K. The last 2 years of life: functional trajectories of frail older people. J Am Geriatr Soc. 2003 Apr; 51(4):492-8. PMID: 12657068.
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    448. Mehta KM, Simonsick EM, Penninx BW, Schulz R, Rubin SM, Satterfield S, Yaffe K. Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study. J Am Geriatr Soc. 2003 Apr; 51(4):499-504. PMID: 12657069.
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    449. Barton C, Miller B, Yaffe K. Evaluation of the diagnosis and management of cognitive impairment in long-term care. Alzheimer Dis Assoc Disord. 2003 Apr-Jun; 17(2):72-6. PMID: 12794383.
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    450. Whitmer RA, Haan MN, Miller JW, Yaffe K. Hormone replacement therapy and cognitive performance: the role of homocysteine. J Gerontol A Biol Sci Med Sci. 2003 Apr; 58(4):324-30. PMID: 12663696.
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    451. Trinh NH, Hoblyn J, Mohanty S, Yaffe K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003 Jan 08; 289(2):210-6. PMID: 12517232.
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    452. Grundman M, Jack CR, Petersen RC, Kim HT, Taylor C, Datvian M, Weiner MF, DeCarli C, DeKosky ST, van Dyck C, Darvesh S, Yaffe K, Kaye J, Ferris SH, Thomas RG, Thal LJ. Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment. J Mol Neurosci. 2003; 20(3):241-8. PMID: 14501003.
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    453. Sands LP, Yaffe K, Covinsky K, Chren MM, Counsell S, Palmer R, Fortinsky R, Landefeld CS. Cognitive screening predicts magnitude of functional recovery from admission to 3 months after discharge in hospitalized elders. J Gerontol A Biol Sci Med Sci. 2003 Jan; 58(1):37-45. PMID: 12560409.
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    454. Kramer JH, Yaffe K, Lengenfelder J, Delis DC. Age and gender interactions on verbal memory performance. J Int Neuropsychol Soc. 2003 Jan; 9(1):97-102. PMID: 12570363.
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    455. Lui LY, Stone K, Cauley JA, Hillier T, Yaffe K. Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. J Am Geriatr Soc. 2003 Jan; 51(1):38-43. PMID: 12534843.
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    456. Grady D, Yaffe K, Kristof M, Lin F, Richards C, Barrett-Connor E. Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med. 2002 Nov; 113(7):543-8. PMID: 12459399.
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    457. Sands LP, Yaffe K, Lui LY, Stewart A, Eng C, Covinsky K. The effects of acute illness on ADL decline over 1 year in frail older adults with and without cognitive impairment. J Gerontol A Biol Sci Med Sci. 2002 Jul; 57(7):M449-54. PMID: 12084807.
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    458. Mehta KM, Yaffe K, Covinsky KE. Cognitive impairment, depressive symptoms, and functional decline in older people. J Am Geriatr Soc. 2002 Jun; 50(6):1045-50. PMID: 12110064; PMCID: PMC2939718.
    459. Yaffe K, Fox P, Newcomer R, Sands L, Lindquist K, Dane K, Covinsky KE. Patient and caregiver characteristics and nursing home placement in patients with dementia. JAMA. 2002 Apr 24; 287(16):2090-7. PMID: 11966383.
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    460. Yaffe K, Lui LY, Grady D, Stone K, Morin P. Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women. Biol Psychiatry. 2002 Apr 15; 51(8):677-82. PMID: 11955468.
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    461. Yaffe K, Lui LY, Zmuda J, Cauley J. Sex hormones and cognitive function in older men. J Am Geriatr Soc. 2002 Apr; 50(4):707-12. PMID: 11982672.
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    462. Yaffe K, Barrett-Connor E, Lin F, Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol. 2002 Mar; 59(3):378-84. PMID: 11890840.
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