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Bassem Al-Sady, PhD

Title(s)Assistant Professor, Microbiology and Immunology
SchoolSchool of Medicine
Phone415-502-8655
ORCID ORCID Icon0000-0002-8996-7941 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Oxford University, U.K.Master of Biochemistry2000Biochemistry
    University of California at BerkeleyPh.D.2006Plant and Microbial Biology
    Collapse Awards and Honors
    National Institutes of Health2016  - 2021New Innovator Award (DP2)

    Collapse Research 
    Collapse Research Activities and Funding
    Reconstructing dynamic epigenetic genome partitioning in single stem cells
    NIH/NIGMS DP2GM123484Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B. Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability. Genes Dev. 2020 01 01; 34(1-2):99-117. PMID: 31805521.
      View in: PubMed
    2. Greenstein RA, Al-Sady B. Epigenetic fates of gene silencing established by heterochromatin spreading in cell identity and genome stability. Curr Genet. 2019 Apr; 65(2):423-428. PMID: 30390097.
      View in: PubMed
    3. Greenstein RA, Jones SK, Spivey EC, Rybarski JR, Finkelstein IJ, Al-Sady B. Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability. Elife. 2018 07 18; 7. PMID: 30020075.
      View in: PubMed
    4. Liv E. Jensen, Bassem Al-Sady, Sy Redding. Chromatin Curtains: A Single-Molecule Method for Visualizing Histone Marks on Chromatin Substrates In Vitro. Biophysical Journal. 2018 Feb 1; 114(3):254a.
      View in: Publisher Site
    5. Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD. Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics. PLoS One. 2016; 11(8):e0159292. PMID: 27479698.
      View in: PubMed
    6. Soy J, Leivar P, González-Schain N, Martín G, Diaz C, Sentandreu M, Al-Sady B, Quail PH, Monte E. Molecular convergence of clock and photosensory pathways through PIF3-TOC1 interaction and co-occupancy of target promoters. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4870-5. PMID: 27071129.
      View in: PubMed
    7. Garcia JF, Al-Sady B, Madhani HD. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. G3 (Bethesda). 2015 May 08; 5(7):1453-61. PMID: 25957277.
      View in: PubMed
    8. Al-Sady B, Madhani HD, Narlikar GJ. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol Cell. 2013 Jul 11; 51(1):80-91. PMID: 23849629.
      View in: PubMed
    9. Shiau C, Trnka MJ, Bozicevic A, Ortiz Torres I, Al-Sady B, Burlingame AL, Narlikar GJ, Fujimori DG. Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase. Chem Biol. 2013 Apr 18; 20(4):494-9. PMID: 23601638.
      View in: PubMed
    10. Leivar P, Tepperman JM, Cohn MM, Monte E, Al-Sady B, Erickson E, Quail PH. Dynamic antagonism between phytochromes and PIF family basic helix-loop-helix factors induces selective reciprocal responses to light and shade in a rapidly responsive transcriptional network in Arabidopsis. Plant Cell. 2012 Apr; 24(4):1398-419. PMID: 22517317.
      View in: PubMed
    11. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 07; 41(1):67-81. PMID: 21211724.
      View in: PubMed
    12. Leivar P, Monte E, Al-Sady B, Carle C, Storer A, Alonso JM, Ecker JR, Quail PH. The Arabidopsis phytochrome-interacting factor PIF7, together with PIF3 and PIF4, regulates responses to prolonged red light by modulating phyB levels. Plant Cell. 2008 Feb; 20(2):337-52. PMID: 18252845.
      View in: PubMed
    13. Al-Sady B, Kikis EA, Monte E, Quail PH. Mechanistic duality of transcription factor function in phytochrome signaling. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2232-7. PMID: 18245378.
      View in: PubMed
    14. Monte E, Al-Sady B, Leivar P, Quail PH. Out of the dark: how the PIFs are unmasking a dual temporal mechanism of phytochrome signalling. J Exp Bot. 2007; 58(12):3125-33. PMID: 17855731.
      View in: PubMed
    15. Al-Sady B, Ni W, Kircher S, Schäfer E, Quail PH. Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation. Mol Cell. 2006 Aug 04; 23(3):439-46. PMID: 16885032.
      View in: PubMed
    16. Monte E, Tepperman JM, Al-Sady B, Kaczorowski KA, Alonso JM, Ecker JR, Li X, Zhang Y, Quail PH. The phytochrome-interacting transcription factor, PIF3, acts early, selectively, and positively in light-induced chloroplast development. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16091-8. PMID: 15505214.
      View in: PubMed
    17. Khanna R, Huq E, Kikis EA, Al-Sady B, Lanzatella C, Quail PH. A novel molecular recognition motif necessary for targeting photoactivated phytochrome signaling to specific basic helix-loop-helix transcription factors. Plant Cell. 2004 Nov; 16(11):3033-44. PMID: 15486100.
      View in: PubMed
    18. Huq E, Al-Sady B, Hudson M, Kim C, Apel K, Quail PH. Phytochrome-interacting factor 1 is a critical bHLH regulator of chlorophyll biosynthesis. Science. 2004 Sep 24; 305(5692):1937-41. PMID: 15448264.
      View in: PubMed
    19. Huq E, Al-Sady B, Quail PH. Nuclear translocation of the photoreceptor phytochrome B is necessary for its biological function in seedling photomorphogenesis. Plant J. 2003 Sep; 35(5):660-4. PMID: 12940958.
      View in: PubMed