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The role of the super-relaxed state of myosin in human metabolism. Metabol Open. 2021 Mar; 9:100068.
Wilson C, Naber N, Cooke R. PMID: 33364594.
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Piperine, an alkaloid inhibiting the super-relaxed state of myosin, binds to the myosin regulatory light chain. Arch Biochem Biophys. 2018 12 01; 659:75-84.
Tolkatchev D, Elnatan D, Nogara L, Ly T, Naber N, Haak K, Meech R, Cooke R, Kostyukova AS. PMID: 30287237.
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PubMed Mentions:
2 Fields:
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AnimalsCells
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Piperine's mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13009-13014.
Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. PMID: 27799519.
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12 Fields:
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AnimalsCells
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Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle. PLoS One. 2016; 11(8):e0160100.
Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. PMID: 27479128.
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PubMed Mentions:
14 Fields:
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AnimalsCells
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A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. Elife. 2014 Dec 22; 3.
Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA. PMID: 25531069.
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19 Fields:
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HumansCells
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The myosin inhibitor blebbistatin stabilizes the super-relaxed state in skeletal muscle. Biophys J. 2014 Oct 07; 107(7):1637-46.
Wilson C, Naber N, Pate E, Cooke R. PMID: 25296316.
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36 Fields:
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AnimalsCells
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The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme. J Mol Biol. 2014 May 15; 426(10):2034-44.
Racki LR, Naber N, Pate E, Leonard JD, Cooke R, Narlikar GJ. PMID: 24607692.
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11 Fields:
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HumansAnimalsCells
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A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81.
Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. PMID: 23485968.
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60 Fields:
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AnimalsCells
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Conformational changes at the nucleotide site in the presence of bound ADP do not set the velocity of fast Drosophila myosins. J Muscle Res Cell Motil. 2013 Feb; 34(1):35-42.
Eldred CC, Naber N, Pate E, Cooke R, Swank DM. PMID: 23203294.
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3 Fields:
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AnimalsCells
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The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5. Biophys J. 2011 Dec 07; 101(11):2760-9.
Waitzman JS, Larson AG, Cochran JC, Naber N, Cooke R, Jon Kull F, Pate E, Rice SE. PMID: 22261065.
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15 Fields:
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HumansCells
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Analysis of the interaction of the Eg5 Loop5 with the nucleotide site. J Theor Biol. 2011 Nov 21; 289:107-15.
Harrington TD, Naber N, Larson AG, Cooke R, Rice SE, Pate E. PMID: 21872609.
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4 Fields:
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HumansCells
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Slow myosin ATP turnover in the super-relaxed state in tarantula muscle. J Mol Biol. 2011 Sep 02; 411(5):943-50.
Naber N, Cooke R, Pate E. PMID: 21763701.
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38 Fields:
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AnimalsCells
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EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin. J Mol Biol. 2011 Aug 05; 411(1):16-26.
Purcell TJ, Naber N, Sutton S, Cooke R, Pate E. PMID: 21640122.
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1 Fields:
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AnimalsCells
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Multiple conformations of the nucleotide site of Kinesin family motors in the triphosphate state. J Mol Biol. 2011 May 13; 408(4):628-42.
Naber N, Larson A, Rice S, Cooke R, Pate E. PMID: 21277856.
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4 Fields:
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HumansAnimalsCells
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Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency. J Mol Biol. 2011 Mar 18; 407(1):79-91.
Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R. PMID: 21185304.
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PubMed Mentions:
9 Fields:
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AnimalsCells
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The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5. Biophys J. 2010 Jun 02; 98(11):2619-27.
Larson AG, Naber N, Cooke R, Pate E, Rice SE. PMID: 20513406.
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21 Fields:
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Cells
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Combining EPR with fluorescence spectroscopy to monitor conformational changes at the myosin nucleotide pocket. J Mol Biol. 2010 Mar 05; 396(4):937-48.
Naber N, Málnási-Csizmadia A, Purcell TJ, Cooke R, Pate E. PMID: 20036250.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature. 2009 Dec 24; 462(7276):1016-21.
Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ. PMID: 20033039.
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PubMed Mentions:
89 Fields:
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HumansAnimalsCells
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The fate of free radicals in a cellulose based hydrogel: detection by electron paramagnetic resonance spectroscopy. J Pharm Sci. 2009 Jul; 98(7):2464-71.
Basumallick L, Ji JA, Naber N, Wang YJ. PMID: 19090570.
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3 Fields:
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The Kinesin-1 tail conformationally restricts the nucleotide pocket. Biophys J. 2009 Apr 08; 96(7):2799-807.
Wong YL, Dietrich KA, Naber N, Cooke R, Rice SE. PMID: 19348763.
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16 Fields:
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HumansCells
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Structural dynamics of the actomyosin complex probed by a bifunctional spin label that cross-links SH1 and SH2. Biophys J. 2008 Dec; 95(11):5238-46.
Thompson AR, Naber N, Wilson C, Cooke R, Thomas DD. PMID: 18805936.
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14 Fields:
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AnimalsCells
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Dynamics of the nucleotide pocket of myosin measured by spin-labeled nucleotides. Biophys J. 2007 Jan 01; 92(1):172-84.
Naber N, Purcell TJ, Pate E, Cooke R. PMID: 17028139.
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17 Fields:
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AnimalsCells
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Conformational variations in an infectious protein determine prion strain differences. Nature. 2004 Mar 18; 428(6980):323-8.
Tanaka M, Chien P, Naber N, Cooke R, Weissman JS. PMID: 15029196.
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354 Fields:
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AnimalsCells
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Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules. Science. 2003 May 02; 300(5620):798-801.
Naber N, Minehardt TJ, Rice S, Chen X, Grammer J, Matuska M, Vale RD, Kollman PA, Car R, Yount RG, Cooke R, Pate E. PMID: 12730601.
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PubMed Mentions:
26 Fields:
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HumansAnimalsCells
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EPR spectroscopy shows a microtubule-dependent conformational change in the kinesin switch 1 domain. Biophys J. 2003 May; 84(5):3190-6.
Naber N, Rice S, Matuska M, Vale RD, Cooke R, Pate E. PMID: 12719248.
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PubMed Mentions:
16 Fields:
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Cells
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Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat Struct Biol. 2002 Nov; 9(11):844-8.
Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R. PMID: 12368902.
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PubMed Mentions:
56 Fields:
Translation:
Cells