Irfan Kathiriya, MD, PhD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
ORCID ORCID Icon0000-0003-1207-1490 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical fellow2011Pediatric Anesthesia
    University of California, San FranciscoClinical fellow2010Pediatric Cardiac Anesthesia
    University of California, San FranciscoResidency 2009Anesthesia & Perioperative Care
    University of California, San FranciscoInternship2006Pediatrics
    University of Texas SouthwesternM.D., Ph.D.2005School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Patterning Mechanisms for Ventricular Septation and Congenital Heart Defects
    NIH 1R56HL166894-01A1Sep 15, 2024 - Aug 30, 2025
    Mechanisms for Ventricular Septation: Implications for Congenital Heart Disease
    Saving tiny Hearts Society Jul 1, 2023 - Jun 30, 2025
    Cell-Cell Signaling Mechanisms for Heart Development: A Pilot Project
    Pediatric Heart Center Catalyst AwardNov 1, 2022 - Oct 31, 2024
    Gene regulatory networks for heart development
    NIH R01HL155906Jan 1, 2021 - Dec 31, 2024
    Role: Co-Investigator
    Genetic determinants of 4D genome folding in human cardiac development
    NIH U01HL157989Sep 21, 2020 - Aug 31, 2025
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In preprints: insights into human heart development and congenital heart defects. Development. 2024 Aug 15; 151(16). Kathiriya IS. PMID: 39177284.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. A single institution anesthetic experience with catheterization of pediatric pulmonary hypertension patients. Pulm Circ. 2024 Apr; 14(2):e12360. Morell E, Colglazier E, Becerra J, Stevens L, Steurer MA, Sharma A, Nguyen H, Kathiriya IS, Weston S, Teitel D, Keller R, Amin EK, Nawaytou H, Fineman JR. PMID: 38618291; PMCID: PMC11010955.
      View in: PubMed   Mentions: 1  
    3. A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects. bioRxiv. 2024 Mar 04. Kathiriya IS, Dominguez MH, Rao KS, Muncie-Vasic JM, Devine WP, Hu KM, Hota SK, Garay BI, Quintero D, Goyal P, Matthews MN, Thomas R, Sukonnik T, Miguel-Perez D, Winchester S, Brower EF, Forjaz A, Wu PH, Wirtz D, Kiemen AL, Bruneau BG. PMID: 38370632; PMCID: PMC10871243.
      View in: PubMed   Mentions:
    4. Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis. Bioinform Adv. 2022; 2(1):vbac051. Blair AP, Hu RK, Farah EN, Chi NC, Pollard KS, Przytycki PF, Kathiriya IS, Bruneau BG. PMID: 35967929; PMCID: PMC9362878.
      View in: PubMed   Mentions:
    5. Brahma safeguards canalization of cardiac mesoderm differentiation. Nature. 2022 02; 602(7895):129-134. Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, Kathiriya IS, Krogan NJ, Saucerman JJ, Bruneau BG. PMID: 35082446; PMCID: PMC9196993.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    6. Interactive anesthesiology educational program improves wellness for anesthesiologists and their children. J Clin Anesth. 2021 06; 70:110192. Jung MJ, Libaw JS, Manuel SP, Kathiriya IS, Srejic U, Gandhi S. PMID: 33556792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9. Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, Haeussler M, Pu WT, Stuart JM, Seidman CE, Seidman JG, Heyn H, Bruneau BG. PMID: 33321106; PMCID: PMC7878434.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    8. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development. 2019 12 09; 146(23). George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG. PMID: 31784461; PMCID: PMC6918742.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    9. A TBX5 dosage-sensitive gene regulatory network for human congenital heart disease. bioRxiv. 2019 Nov 8; 835603. Kathiriya KI, Rao RK, Iacono IG, Devine DW, Hota HS, Lai LM, Garay GB, Thomas TR, Blair BA, Gong GH, Wasson WL, Goyal GP, Sukonnik ST, Akgun AG, Bernard BL, Akerberg AB, Gu GF, Li LK, Pu PW, Stuart SJ, Seidman SC, Seidman SJ, Heyn HH, Bruneau BB. .
      View in: Publisher Site   Mentions:
    10. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. bioRxiv. 2019 Oct 4; 793257. George GM, Duan DQ, Nagle NA, Kathiriya KI, Huang HY, Rao RK, Haldar HS, Bruneau BB. .
      View in: Publisher Site   Mentions:
    11. The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Development. 2017 03 01; 144(5):866-875. Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN. PMID: 28246214; PMCID: PMC5374346.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. PMID: 27840107; PMCID: PMC5198784.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimalsCells
    13. Investigating the transcriptional control of cardiovascular development. Circ Res. 2015 Feb 13; 116(4):700-14. Kathiriya IS, Nora EP, Bruneau BG. PMID: 25677518; PMCID: PMC4332409.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    14. Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. Am J Med Genet A. 2007 Apr 15; 143A(8):817-23. Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V. PMID: 17352393.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    15. Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem Biophys Res Commun. 2006 Jun 23; 345(1):446-52. King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O. PMID: 16682003.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb; 38(2):175-83. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. PMID: 16380715.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    17. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem. 2004 Dec 24; 279(52):54937-43. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. PMID: 15485867.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    18. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature. 2003 Jul 24; 424(6947):443-7. Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D. PMID: 12845333.
      View in: PubMed   Mentions: 434     Fields:    Translation:HumansAnimalsCells
    19. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol. 2001 Jul 01; 235(1):62-73. Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D. PMID: 11412027.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    20. Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development. 2000 May; 127(10):2133-42. Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA. PMID: 10769237.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    21. Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. Am J Med Genet. 2000; 97(4):271-9. Kathiriya IS, Srivastava D. PMID: 11376438.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    22. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem Biol. 1999 Jun; 6(6):343-51. Hamilton SE, Simmons CG, Kathiriya IS, Corey DR. PMID: 10375543.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
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