Isha Jain, PhD

Title(s)Assistant Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address35 Medical Center Way, #1035
San Francisco CA 94143
Phone--
ORCID ORCID Icon0000-0001-5053-0964 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard University, Cambridge, MAAB06/2012Chemical and Physical Biology
    Massachusetts Institute of Technology, Cambridge, MAPhD09/2017Computer Science, Systems Biology
    Collapse Awards and Honors
    2018  - 2023NIH Early Independence Award (DP5)
    2018Glenn Award for Aging Research
    2018  - 2020American Federation for Aging Research Junior Faculty Grant
    2018  - 2023UCSF Sandler Faculty Fellowship
    2017Harold Weintraub Graduate Student Award
    2016Philantropic Educational Organization National Scholar Award ($15K)
    2013  - 2016Department of Energy Computational Sciences Graduate Fellowship
    2011Barry Goldwater Award
    2009Glamour Magazine's Top 10 College Women
    2008Discover Magazine's Top 5 Scientists Under 20
    2007Siemens Competition in Math, Science and Technology National Individual Winner ($100K)

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Redesigning a Neuron's Breath: A Modern Twist to Classical Oxygen Biology
    NIH DP5OD026398Sep 7, 2018 - Aug 31, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Mol Cell. 2023 03 16; 83(6):942-960.e9. Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH. PMID: 36893757; PMCID: PMC10148707.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism. Cell Metab. 2023 03 07; 35(3):504-516.e5. Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH. PMID: 36889284; PMCID: PMC10077660.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. The Goldilocks Oxygen Principle: not too little and not too much. Nat Cardiovasc Res. 2022 Dec; 1(12):1101-1103. Flanigan WR, Jain IH. PMID: 36816751; PMCID: PMC9937547.
      View in: PubMed   Mentions:
    4. Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer. Cancer Discov. 2022 09 02; 12(9):2198-2219. Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM. PMID: 35771494; PMCID: PMC9444964.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    5. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 01 01; 371(6524):52-57. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. PMID: 33384370; PMCID: PMC8312065.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    6. Turning the Oxygen Dial: Balancing the Highs and Lows. Trends Cell Biol. 2020 07; 30(7):516-536. Baik AH, Jain IH. PMID: 32386878; PMCID: PMC7391449.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism. Cell. 2020 04 30; 181(3):716-727.e11. Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK. PMID: 32259488; PMCID: PMC7293541.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    8. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 10 01; 30(4):824-832.e3. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. PMID: 31402314; PMCID: PMC6903907.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    9. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. PMID: 28483998; PMCID: PMC5448167.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    10. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. PMID: 26917594; PMCID: PMC4860742.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    11. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13638-43. Jain IH, Vijayan V, O'Shea EK. PMID: 22869746; PMCID: PMC3427121.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    12. A high resolution map of a cyanobacterial transcriptome. Genome Biol. 2011; 12(5):R47. Vijayan V, Jain IH, O'Shea EK. PMID: 21612627; PMCID: PMC3219970.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    13. The making of a young scientist. Dev Dyn. 2008 Jun; 237(6):1535-6. Jain I, Iovine K. PMID: 18489006.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Dev Biol. 2008 May 15; 317(2):541-8. Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK. PMID: 18406403; PMCID: PMC2429987.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    15. Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Dev Dyn. 2007 Sep; 236(9):2668-74. Jain I, Stroka C, Yan J, Huang WM, Iovine MK. PMID: 17676636.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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