-
Oncogene-regulated release of extracellular vesicles. Dev Cell. 2021 Jul 12; 56(13):1989-2006.e6.
Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohnz RA, Avsaroglu B, L'Etoile ND, Perera RM, Nomura DK, Goga A. PMID: 34118203.
View in:
PubMed Mentions: Fields:
-
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. Nat Cell Biol. 2021 03; 23(3):232-242.
Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM. PMID: 33686253.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. Dev Cell. 2021 Feb 08; 56(3):260-276.e7.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R. PMID: 33308480.
View in:
PubMed Mentions:
3 Fields:
-
Selective autophagy of MHC-I promotes immune evasion of pancreatic cancer. Autophagy. 2020 08; 16(8):1524-1525.
Yamamoto K, Venida A, Perera RM, Kimmelman AC. PMID: 32459143.
View in:
PubMed Mentions:
4 Fields:
-
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 05; 581(7806):100-105.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. PMID: 32376951.
View in:
PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
-
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. Elife. 2019 05 28; 8.
Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM. PMID: 31134896.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
Host Control of Tumor Feeding: Autophagy Holds the Key. Cell Metab. 2019 02 05; 29(2):236-238.
Venida A, Perera RM. PMID: 30726755.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. Annu Rev Cancer Biol. 2019 03; 3:203-222.
Perera RM, Di Malta C, Ballabio A. PMID: 31650096.
View in:
PubMed Mentions:
-
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science. 2017 06 16; 356(6343):1188-1192.
Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. PMID: 28619945.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
-
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science. 2017 03 24; 355(6331):1306-1311.
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. PMID: 28336668.
View in:
PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
-
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419.
Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. PMID: 27568548.
View in:
PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
-
The Lysosome as a Regulatory Hub. Annu Rev Cell Dev Biol. 2016 10 06; 32:223-253.
Perera RM, Zoncu R. PMID: 27501449.
View in:
PubMed Mentions:
120 Fields:
Translation:
HumansAnimalsCells
-
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up. Cancer Discov. 2015 Dec; 5(12):1247-61.
Perera RM, Bardeesy N. PMID: 26534901.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
-
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20; 524(7565):361-5.
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. PMID: 26168401.
View in:
PubMed Mentions:
256 Fields:
Translation:
HumansAnimalsCells
-
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Rep. 2015 Mar 17; 10(10):1692-1707.
Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N. PMID: 25772357.
View in:
PubMed Mentions:
90 Fields:
-
Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):E3091-100.
Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. PMID: 25024225.
View in:
PubMed Mentions:
173 Fields:
Translation:
HumansAnimalsCells
-
CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers. Cancer Res. 2014 Jul 15; 74(14):3947-58.
Heilmann AM, Perera RM, Ecker V, Nicolay BN, Bardeesy N, Benes CH, Dyson NJ. PMID: 24986516.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013 Apr 04; 496(7443):101-5.
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. PMID: 23535601.
View in:
PubMed Mentions:
643 Fields:
Translation:
HumansCells
-
Ready, set, go: the EGF receptor at the pancreatic cancer starting line. Cancer Cell. 2012 Sep 11; 22(3):281-2.
Perera RM, Bardeesy N. PMID: 22975369.
View in:
PubMed Mentions:
12 Fields:
-
On oncogenes and tumor suppressor genes in the mammary gland. Cold Spring Harb Perspect Biol. 2012 Jun 01; 4(6).
Perera RM, Bardeesy N. PMID: 22661637.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Cancer: when antioxidants are bad. Nature. 2011 Jul 06; 475(7354):43-4.
Perera RM, Bardeesy N. PMID: 21734699.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
-
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol. 2010 Aug 09; 190(3):307-15.
Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. PMID: 20679431.
View in:
PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
-
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010 Mar 15; 70(6):2158-64.
Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DA. PMID: 20215515.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansCells
-
Mechanistic Insights into Membrane Remodeling Through BAR-Domain Proteins. The FASEB Journal. 2009 Apr 1; 23:82.2-82.2.
Adam Frost, Carsten Mim, Rushika Perera, Krasimir Spasov, Edward Egelman, Pietro De Camilli, Vinzenz M Unger. .
View in:
Publisher Site Mentions:
-
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 2009 Mar 20; 136(6):1110-21.
Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. PMID: 19303853.
View in:
PubMed Mentions:
161 Fields:
Translation:
AnimalsCells
-
Structural basis of membrane invagination by F-BAR domains. Cell. 2008 Mar 07; 132(5):807-17.
Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM. PMID: 18329367.
View in:
PubMed Mentions:
251 Fields:
Translation:
HumansAnimalsCells
-
Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody. Neoplasia. 2007 Dec; 9(12):1099-110.
Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM. PMID: 18084617.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
-
The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clin Cancer Res. 2007 Mar 15; 13(6):1911-25.
Johns TG, Perera RM, Vernes SC, Vitali AA, Cao DX, Cavenee WK, Scott AM, Furnari FB. PMID: 17363548.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
-
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3793-8.
Zoncu R, Perera RM, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli PV. PMID: 17360432.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
-
Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19332-7.
Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. PMID: 17158794.
View in:
PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
-
Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity. Clin Cancer Res. 2005 Sep 01; 11(17):6390-9.
Perera RM, Narita Y, Furnari FB, Gan HK, Murone C, Ahlkvist M, Luwor RB, Burgess AW, Stockert E, Jungbluth AA, Old LJ, Cavenee WK, Scott AM, Johns TG. PMID: 16144944.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
-
The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR. Oncogene. 2004 Aug 12; 23(36):6095-104.
Luwor RB, Zhu HJ, Walker F, Vitali AA, Perera RM, Burgess AW, Scott AM, Johns TG. PMID: 15221011.
View in:
PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
-
Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus. J Virol. 2004 May; 78(9):4397-407.
Cornell CT, Perera R, Brunner JE, Semler BL. PMID: 15078921.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15871-6.
Johns TG, Luwor RB, Murone C, Walker F, Weinstock J, Vitali AA, Perera RM, Jungbluth AA, Stockert E, Old LJ, Nice EC, Burgess AW, Scott AM. PMID: 14676326.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells