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Rushika Perera, PhD

Title(s)Assistant Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
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    Collapse Biography 
    Collapse Awards and Honors
    Damon Runyon Cancer Reserach Foundation2017  - 2019Damon Runyon-Rachleff Innovation Award
    National Institute of Health2016  - 2021Director's New Innovator Award
    AACR-Pancreatic Cancer Action Network2016  - 2018Career Development Award
    American Association for Cancer Research2015NEXTGen Star

    Collapse Research 
    Collapse Research Activities and Funding
    Tracking tumor evolution through in vivo organelle profiling
    NIH/NCI DP2CA216364Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selective autophagy of MHC-I promotes immune evasion of pancreatic cancer. Autophagy. 2020 Aug; 16(8):1524-1525. Yamamoto K, Venida A, Perera RM, Kimmelman AC. PMID: 32459143.
      View in: PubMed   Mentions:    Fields:    
    2. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 05; 581(7806):100-105. Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. PMID: 32376951.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. Elife. 2019 05 28; 8. Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM. PMID: 31134896.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Host Control of Tumor Feeding: Autophagy Holds the Key. Cell Metab. 2019 02 05; 29(2):236-238. Venida A, Perera RM. PMID: 30726755.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. Annu Rev Cancer Biol. 2019 03; 3:203-222. Perera RM, Di Malta C, Ballabio A. PMID: 31650096.
      View in: PubMed   Mentions:
    6. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science. 2017 06 16; 356(6343):1188-1192. Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. PMID: 28619945.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    7. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science. 2017 03 24; 355(6331):1306-1311. Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. PMID: 28336668.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    8. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. PMID: 27568548.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    9. The Lysosome as a Regulatory Hub. Annu Rev Cell Dev Biol. 2016 10 06; 32:223-253. Perera RM, Zoncu R. PMID: 27501449.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    10. Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up. Cancer Discov. 2015 Dec; 5(12):1247-61. Perera RM, Bardeesy N. PMID: 26534901.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    11. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20; 524(7565):361-5. Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. PMID: 26168401.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    12. YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Rep. 2015 Mar 17; 10(10):1692-1707. Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N. PMID: 25772357.
      View in: PubMed   Mentions: 58     Fields:    
    13. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):E3091-100. Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. PMID: 25024225.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    14. CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers. Cancer Res. 2014 Jul 15; 74(14):3947-58. Heilmann AM, Perera RM, Ecker V, Nicolay BN, Bardeesy N, Benes CH, Dyson NJ. PMID: 24986516.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    15. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013 Apr 04; 496(7443):101-5. Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. PMID: 23535601.
      View in: PubMed   Mentions: 453     Fields:    Translation:HumansCells
    16. Ready, set, go: the EGF receptor at the pancreatic cancer starting line. Cancer Cell. 2012 Sep 11; 22(3):281-2. Perera RM, Bardeesy N. PMID: 22975369.
      View in: PubMed   Mentions: 11     Fields:    
    17. On oncogenes and tumor suppressor genes in the mammary gland. Cold Spring Harb Perspect Biol. 2012 Jun 01; 4(6). Perera RM, Bardeesy N. PMID: 22661637.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Cancer: when antioxidants are bad. Nature. 2011 Jul 06; 475(7354):43-4. Perera RM, Bardeesy N. PMID: 21734699.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    19. The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol. 2010 Aug 09; 190(3):307-15. Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. PMID: 20679431.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    20. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010 Mar 15; 70(6):2158-64. Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DA. PMID: 20215515.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    21. Mechanistic Insights into Membrane Remodeling Through BAR-Domain Proteins. The FASEB Journal. 2009 Apr 1; 23:82.2-82.2. Adam Frost, Carsten Mim, Rushika Perera, Krasimir Spasov, Edward Egelman, Pietro De Camilli, Vinzenz M Unger. .
      View in: Publisher Site   Mentions:
    22. A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 2009 Mar 20; 136(6):1110-21. Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. PMID: 19303853.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    23. Enveloped viruses understood via multiscale simulation: computer-aided vaccine design. Scientific Modeling and Simulation SMNS. 2008 Apr 1; 15(1-3):363-380. Z. Shreif, P. Adhangale, S. Cheluvaraja, R. Perera, R. Kuhn, P. Ortoleva. .
      View in: Publisher Site   Mentions:
    24. Structural basis of membrane invagination by F-BAR domains. Cell. 2008 Mar 07; 132(5):807-17. Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM. PMID: 18329367.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimalsCells
    25. Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody. Neoplasia. 2007 Dec; 9(12):1099-110. Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM. PMID: 18084617.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clin Cancer Res. 2007 Mar 15; 13(6):1911-25. Johns TG, Perera RM, Vernes SC, Vitali AA, Cao DX, Cavenee WK, Scott AM, Furnari FB. PMID: 17363548.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    27. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3793-8. Zoncu R, Perera RM, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli PV. PMID: 17360432.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    28. Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19332-7. Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. PMID: 17158794.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    29. Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity. Clin Cancer Res. 2005 Sep 01; 11(17):6390-9. Perera RM, Narita Y, Furnari FB, Gan HK, Murone C, Ahlkvist M, Luwor RB, Burgess AW, Stockert E, Jungbluth AA, Old LJ, Cavenee WK, Scott AM, Johns TG. PMID: 16144944.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    30. The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR. Oncogene. 2004 Aug 12; 23(36):6095-104. Luwor RB, Zhu HJ, Walker F, Vitali AA, Perera RM, Burgess AW, Scott AM, Johns TG. PMID: 15221011.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    31. Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15871-6. Johns TG, Luwor RB, Murone C, Walker F, Weinstock J, Vitali AA, Perera RM, Jungbluth AA, Stockert E, Old LJ, Nice EC, Burgess AW, Scott AM. PMID: 14676326.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
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