Abigail (Abby) Buchwalter

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #352R
San Francisco CA 94158
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    Understanding mechanisms of heterochromatin tethering at the nuclear lamina
    NIH R35GM142897Aug 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Identifying links between the nuclear pore complex and the cell cycle
    NIH F32GM103084Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator
    Mechanism and regulation of LULL 1-directed NE enrichment of TorsinA
    NIH F31NS065608Dec 14, 2009 - Dec 13, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin. bioRxiv. 2025 Jan 20. Mella J, Volk R, Zaro B, Buchwalter A. PMID: 39896633; PMCID: PMC11785080.
      View in: PubMed   Mentions:
    2. Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells. PLoS One. 2024; 19(12):e0310626. Blokhina Y, Buchwalter A. PMID: 39666677; PMCID: PMC11637357.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. What does it take to build a nucleus? Nat Rev Mol Cell Biol. 2024 Oct; 25(10):764. Buchwalter A. PMID: 39048753.
      View in: PubMed   Mentions:    Fields:    
    4. The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate. bioRxiv. 2024 Jul 11. Marin H, Simental E, Allen C, Martin E, Panning B, Al-Sady B, Buchwalter A. PMID: 39026839; PMCID: PMC11257442.
      View in: PubMed   Mentions:
    5. Proteome Birthdating Reveals Age-Selectivity of Protein Ubiquitination. Mol Cell Proteomics. 2024 Jul; 23(7):100791. Meadow ME, Broas S, Hoare M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Martinez JC, Biashad SA, Seluanov A, Gorbunova V, Buchwalter A, Ghaemmaghami S. PMID: 38797438; PMCID: PMC11260378.
      View in: PubMed   Mentions: 2     Fields:    
    6. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Sci Adv. 2023 Dec 08; 9(49):eadj4884. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH. PMID: 38064566; PMCID: PMC10708181.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Long lifetime and tissue-specific accumulation of lamin A/C in Hutchinson-Gilford progeria syndrome. J Cell Biol. 2024 01 01; 223(1). Hasper J, Welle K, Swovick K, Hryhorenko J, Ghaemmaghami S, Buchwalter A. PMID: 37966721; PMCID: PMC10651395.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells. bioRxiv. 2023 Nov 01. Blokhina Y, Buchwalter A. PMID: 37904963; PMCID: PMC10614900.
      View in: PubMed   Mentions:
    9. Intermediate, but not average: The unusual lives of the nuclear lamin proteins. Curr Opin Cell Biol. 2023 10; 84:102220. Buchwalter A. PMID: 37619289.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. Long lifetime and selective accumulation of the A-type lamins accounts for the tissue specificity of Hutchinson-Gilford progeria syndrome. bioRxiv. 2023 Apr 28. Hasper J, Welle K, Swovick K, Hryhorenko J, Ghaemmaghami S, Buchwalter A. PMID: 37162946; PMCID: PMC10168242.
      View in: PubMed   Mentions:
    11. Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes. Mol Syst Biol. 2023 04 12; 19(4):e11393. Hasper J, Welle K, Hryhorenko J, Ghaemmaghami S, Buchwalter A. PMID: 36929723; PMCID: PMC10090950.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Moving fast and breaking things: Incidence and repair of DNA damage within ribosomal DNA repeats. Mutat Res. 2020 May - Dec; 821:111715. Blokhina YP, Buchwalter A. PMID: 32717383.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. Elife. 2019 10 10; 8. Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. PMID: 31599721; PMCID: PMC6802967.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    14. Coaching from the sidelines: the nuclear periphery in genome regulation. Nat Rev Genet. 2019 01; 20(1):39-50. Buchwalter A, Kaneshiro JM, Hetzer MW. PMID: 30356165; PMCID: PMC6355253.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    15. Nucleolar expansion and elevated protein translation in premature aging. Nat Commun. 2017 08 30; 8(1):328. Buchwalter A, Hetzer MW. PMID: 28855503; PMCID: PMC5577202.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    16. Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum. J Cell Sci. 2015 Aug 01; 128(15):2854-65. Goodchild RE, Buchwalter AL, Naismith TV, Holbrook K, Billion K, Dauer WT, Liang CC, Dear ML, Hanson PI. PMID: 26092934; PMCID: PMC4540951.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    17. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell. 2014 Aug 15; 25(16):2472-84. Buchwalter AL, Liang Y, Hetzer MW. PMID: 24943837; PMCID: PMC4142618.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    18. Nuclear pores set the speed limit for mitosis. Cell. 2014 Feb 27; 156(5):868-9. Buchwalter A, Hetzer MW. PMID: 24581486; PMCID: PMC4008093.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum. EMBO J. 2011 Jul 22; 30(16):3217-31. Vander Heyden AB, Naismith TV, Snapp EL, Hanson PI. PMID: 21785409; PMCID: PMC3160655.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    20. LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol Biol Cell. 2009 Jun; 20(11):2661-72. Vander Heyden AB, Naismith TV, Snapp EL, Hodzic D, Hanson PI. PMID: 19339278; PMCID: PMC2688546.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    21. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Microvasc Res. 2008 Mar; 75(2):155-68. Buchwalter A, Van Dort C, Schultz S, Smith R, Le IP, Abbott JL, Oosterhouse E, Johnson AE, Hansen-Smith F, Burnatowska-Hledin M. PMID: 17950367.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    22. Estrogen-dependent growth and estrogen receptor (ER)-alpha concentration in T47D breast cancer cells are inhibited by VACM-1, a cul 5 gene. Mol Cell Biochem. 2007 Jul; 301(1-2):13-20. Johnson AE, Le IP, Buchwalter A, Burnatowska-Hledin MA. PMID: 17186378.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    23. R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism. J Biol Chem. 2006 Sep 22; 281(38):28222-31. Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ. PMID: 16867977.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
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