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Tien Peng, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-502-4852
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    Collapse Biography 
    Collapse Education and Training
    University of VirginiaB.A.2000
    Johns Hopkins UniversityM.D.2006School of Medicine
    Columbia University Medical CenterInternal Medicine Residency2009
    University of PennsylvaniaClinical/Postdoctoral Fellowship2015Pulmonary Medicine/Cell and Developmental Biology
    Collapse Awards and Honors
    Federation of American Societies for Experimental Biology2014Jo Rae Wright Award
    American Society for Clinical Investigation2016Young Physician Scientist Award
    National Institutes of Health2016  - 2021NIH New Innovator Award

    Collapse Overview 
    Collapse Overview
    The Peng Lab is interested in how the mesenchyal compartment integrates extracellular cues to modify the niche, with a focus on the niche supporting resident tissue stem cells. We utilize complex murine genetic models and human specimen to interrogate how distinct mesenchymal compartments maintain organ homeostasis, initiate disease, and drive tissue aging. Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

    Collapse Research 
    Collapse Research Activities and Funding
    Maintenance of the alveolar niche in emphysema
    NIH/NHLBI R01HL142552Aug 22, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Defining the resident mesenchymal stem cell niche and function in vivo
    NIH/NIA DP2AG056034Sep 30, 2016 - Jun 30, 2021
    Role: Principal Investigator
    The roles of Hedgehog signaling in pulmonary vascular development and remodeling
    NIH/NHLBI K08HL121146Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell. 2019 Feb 20; e12914. PMID: 30790400.
      View in: PubMed
    2. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 Feb 15. PMID: 30824323.
      View in: PubMed
    3. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 Oct 01; 128(10):4343-4358. PMID: 29999500.
      View in: PubMed
    4. Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 11 22; 17(9):2312-2325. PMID: 27880906.
      View in: PubMed
    5. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82. PMID: 26436454; PMCID: PMC4713039.
    6. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79. PMID: 24939938; PMCID: PMC4066405.
    7. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 05; 13(6):720-33. PMID: 24315444; PMCID: PMC3900235.
    8. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92. PMID: 23873040.
      View in: PubMed
    9. Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8. PMID: 23662197; PMCID: PMC3641728.
    10. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60. PMID: 19399660; PMCID: PMC2819481.
    11. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5. PMID: 18091066; PMCID: PMC3991117.
    12. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52. PMID: 17440165.
      View in: PubMed
    13. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158. PMID: 16526403.
      View in: PubMed
    14. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38. PMID: 12788657.
      View in: PubMed