Tien Peng * UCSF Profiles

Tien Peng, MD

Title(s)	Assistant Professor, Medicine
School	School of Medicine
Phone	415-502-4852
ORCID	0000-0002-2226-4635
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Biography

Education and Training

University of Virginia	B.A.	2000
Johns Hopkins University	M.D.	2006	School of Medicine
Columbia University Medical Center	Internal Medicine Residency	2009
University of Pennsylvania	Clinical/Postdoctoral Fellowship	2015	Pulmonary Medicine/Cell and Developmental Biology

Awards and Honors

Federation of American Societies for Experimental Biology	2014		Jo Rae Wright Award
American Society for Clinical Investigation	2016		Young Physician Scientist Award
National Institutes of Health	2016 -	2021	NIH New Innovator Award

Overview

The Peng Lab is interested in how the mesenchymal compartment integrates extracellular cues to modify the niche, with a focus on the niche supporting resident tissue stem cells. We utilize complex murine genetic models and human specimen to interrogate how mesenchymal compartments maintain organ homeostasis, initiate disease, and drive tissue aging. Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

Research

Research Activities and Funding

Maintenance of the alveolar niche in emphysema
NIH/NHLBI R01HL142552Aug 22, 2018 - Jun 30, 2022
Role: Principal Investigator

Defining the resident mesenchymal stem cell niche and function in vivo
NIH/NIA DP2AG056034Sep 30, 2016 - Jun 30, 2021
Role: Principal Investigator

The roles of Hedgehog signaling in pulmonary vascular development and remodeling
NIH/NHLBI K08HL121146Sep 1, 2014 - Jun 30, 2019
Role: Principal Investigator

ORNG Applications

Websites

In The News

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Wang C, Cassandras M, Peng T. The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance. J Dev Biol. 2019 Jul 09; 7(3). PMID: 31323955.

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Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 Mar 19; 50(3):707-722.e6. PMID: 30824323.

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Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell. 2019 Feb 20; e12914. PMID: 30790400.

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Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. PMID: 29999500.

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Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 11 22; 17(9):2312-2325. PMID: 27880906.

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Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82. PMID: 26436454.

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Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79. PMID: 24939938.

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Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 05; 13(6):720-33. PMID: 24315444.

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Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92. PMID: 23873040.

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Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8. PMID: 23662197.

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Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60. PMID: 19399660.

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Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5. PMID: 18091066.

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Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52. PMID: 17440165.

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Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158. PMID: 16526403.

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Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38. PMID: 12788657.

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