Joseph Blecha, MS

Title(s)Specialist, Radiology
SchoolSchool of Medicine
Address185 Berry Street
San Francisco CA 94143
Phone415-353-4436
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    1. Longitudinal imaging of T-cells and inflammatory demyelination in a preclinical model of multiple sclerosis using 18F-FAraG PET and MRI. J Nucl Med. 2021 Apr 09. Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, Van Brocklin HF, Chaumeil MM. PMID: 33837066.
      View in: PubMed   Mentions:    Fields:    
    2. Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2. J Nucl Med. 2021 Feb 26. Parker M, Blecha J, Rosenberg O, Ohliger M, Flavell RR, Wilson DM. PMID: 33637588.
      View in: PubMed   Mentions:    Fields:    
    3. Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats. Chem Res Toxicol. 2021 01 18; 34(1):63-69. Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF. PMID: 33373198.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Dose Formulation, Biodistribution and PET Imaging Studies of a First-In-Class Fluorine-18 Organophosphorus Cholinesterase Inhibitor Tracer in Rat. Current Chemical Biology. 2020 Oct 5; 14. Neumann NK, Blecha BJ, Chao CC, Huynh HT, Zinn ZK, VanBrocklin VH, Thompson TC, Gerdes GJ. .
      View in: Publisher Site   Mentions:
    5. The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-11C-YJH08 PET. J Nucl Med. 2021 05 10; 62(5):723-731. Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Parker MFL, Blecha JE, Drake CR, VanBrocklin HF, Garrido-Ruiz D, Jacobson MP, Aggarwal R, Behr SC, Flavell RR, Wilson DM, Seo Y, Evans MJ. PMID: 32887758.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [18 F]-VXS. Ann N Y Acad Sci. 2020 11; 1479(1):180-195. Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HF, Zinn KR, Taylor PW, Gerdes JM, Thompson CM. PMID: 32436233.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chem Biol. 2020 06 19; 15(6):1381-1391. Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ. PMID: 32255605.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms. J Labelled Comp Radiopharm. 2020 05 15; 63(5):231-239. Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 32222086.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. PET/CT Imaging of Human TNFα Using [89Zr]Certolizumab Pegol in a Transgenic Preclinical Model of Rheumatoid Arthritis. Mol Imaging Biol. 2020 02; 22(1):105-114. Beckford-Vera DR, Gonzalez-Junca A, Janneck JS, Huynh TL, Blecha JE, Seo Y, Li X, VanBrocklin HF, Franc BL. PMID: 31065895.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    10. High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection. ACS Infect Dis. 2020 01 10; 6(1):43-49. Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM. PMID: 31697062.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy. Mol Pharm. 2019 09 03; 16(9):3831-3841. Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR. PMID: 31381351.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. OP#41 Immuno-PET imaging of human tumor necrosis factor alpha in a transgenic mouse model of rheumatoid arthritis. Nuclear Medicine and Biology. 2019 Jul 1; 72:s16-s17. Beckford BV, Fu FC, Janneck JJ, Huynh HT, Blecha BJ, Li LX, Franc FB, Vanbrocklin VH. .
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    13. Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials. Appl Radiat Isot. 2019 Sep; 151:182-186. Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF. PMID: 31202183.
      View in: PubMed   Mentions: 1     Fields:    
    14. Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy. Cancer Res. 2019 07 01; 79(13):3455-3465. Levi J, Lam T, Goth SR, Yaghoubi S, Bates J, Ren G, Jivan S, Huynh TL, Blecha JE, Khattri R, Schmidt KF, Jennings D, VanBrocklin H. PMID: 31064845.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer. J Nucl Med. 2019 07; 60(7):910-916. Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y. PMID: 30464040.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    16. Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin. J Labelled Comp Radiopharm. 2018 12; 61(14):1089-1094. Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF. PMID: 30347484.
      View in: PubMed   Mentions: 3     Fields:    
    17. Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication. ACS Chem Neurosci. 2018 12 19; 9(12):3007-3014. Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM. PMID: 30071719.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018 May 17; 54(41):5233-5236. Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 29726563.
      View in: PubMed   Mentions: 10     Fields:    
    19. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 07 13; 4(7):1067-1072. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. PMID: 29712422.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    20. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 08 11; 7(1):7903. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 28801560.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    21. First-in-human phase 1 PET study of CTT1057, a novel 18 F-labeled imaging agent targeting prostate specific membrane antigen (PSMA) in prostate cancer. Journal of Clinical Oncology. 2017 May 20; 35(15_suppl):e16562-e16562. Aggarwal AR, Behr BS, Seo SY, Gao GK, Rahanfar RV, Slater SJ, Blecha BJ, Langton-Webster LB, Berkman BC, Vanbrocklin VH. .
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    22. An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer. J Labelled Comp Radiopharm. 2017 06 15; 60(7):337-342. Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF. PMID: 28406525.
      View in: PubMed   Mentions: 4     Fields:    
    23. An updated synthesis of [11 C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor. J Labelled Comp Radiopharm. 2017 06 30; 60(8):375-380. Blecha JE, Henderson BD, Hockley BG, VanBrocklin HF, Zubieta JK, DaSilva AF, Kilbourn MR, Koeppe RA, Scott PJH, Shao X. PMID: 28419528.
      View in: PubMed   Mentions: 5     Fields:    
    24. In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis. Mol Imaging. 2017 01 01; 16:1536012117712638. Franc BL, Goth S, MacKenzie J, Li X, Blecha J, Lam T, Jivan S, Hawkins RA, VanBrocklin H. PMID: 28625080.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer. J Med Chem. 2016 06 23; 59(12):5684-94. Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman CE, VanBrocklin HF. PMID: 27228467.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol. 2016 06; 18(3):360-7. Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. PMID: 26567114.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. Brain. 2016 07; 139(Pt 7):1994-2001. Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ. PMID: 27234268.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    28. Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography. Bioconjug Chem. 2016 Jan 20; 27(1):170-8. Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM. PMID: 26649808.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    29. NIMG-45REAL-TIME PET IMAGING DEMONSTRATES TUMOR ACCUMULATION AND OXYGENATION BY OMX-4.80P, AN OXYGEN CARRIER ENGINEERED FOR THE TREATMENT OF GLIOBLASTOMA. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v164-v164. Serwer SL, Le Moan LN, Regan RM, Blecha BJ, Davis DA, Tanaka TK, Keating KT, Romero RJ, Leung LP, Davis DT, Bedard BC, Ng NS, Yan YF, Santos SR, Ozawa OT, Butowski BN, Cary CS, Nicolaides NT, Seo SY, Winger WJ, VanBrocklin VH, Krtolica KA. .
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    30. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM. PMID: 26257040.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    31. A high-affinity [(18)F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer. Nucl Med Biol. 2015 Oct; 42(10):780-7. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Ganguly T, Dannoon S, Hopkins MR, Murphy S, Cahaya H, Blecha JE, Jivan S, Drake CR, Barinka C, Jones EF, VanBrocklin HF, Berkman CE. PMID: 26169882; PMCID: PMC4624265.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. EHMTI-0125. Studying the permeability of the blood-brain barrier during migraine attacks using [11C]-dihydroergotamine. The Journal of Headache and Pain. 2014 Dec 1; 15(Suppl 1):f22. Schankin SC, Maniyar MF, Seo SY, Kori KS, Eller EM, Blecha BJ, Murphy MS, Sprenger ST, VanBrocklin VH, Goadsby GP. .
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    33. A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography. J Am Chem Soc. 2014 Oct 22; 136(42):14742-5. Carroll V, Michel BW, Blecha J, VanBrocklin H, Keshari K, Wilson D, Chang CJ. PMID: 25310369.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    34. Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs. Bioorg Med Chem Lett. 2007 Jul 15; 17(14):4026-9. Blecha JE, Anderson MO, Chow JM, Guevarra CC, Pender C, Penaranda C, Zavodovskaya M, Youngren JF, Berkman CE. PMID: 17502145.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    35. Stereoselective inhibition of glutamate carboxypeptidase by organophosphorus derivatives of glutamic acid. Bioorg Med Chem. 2004 Nov 15; 12(22):6011-20. Mallari JP, Choy CJ, Hu Y, Martinez AR, Hosaka M, Toriyabe Y, Maung J, Blecha JE, Pavkovic SF, Berkman CE. PMID: 15498677.
      View in: PubMed   Mentions: 3     Fields:    
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