James Brown, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-221-4810 ext. 26464
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New HavenBA06/1968Pre-Med, History
    Johns Hopkins University School of Medicine, BaltimoreMD06/1972Medicine
    Johns Hopkins Hospital, BaltimoreR1 and R206/1974Internal Medicine
    University of California, San FranciscoR306/1975Internal Medicine
    University of California Medical Center, San FranciscoChief Medical Resident06/1976Internal Medicine
    University of California , San FranciscoFellow06/1979Pulmonary and Critical Care Medicine
    University of California and Cardiovascular Research Institute, San FranciscoClinical Instructor, Assistant Research Scientist06/1981Pulmonary research
    Collapse Awards and Honors
    University of California, San Francisco1979  - 1981Parker B. Francis Fellowship
    University of California, San Francisco1985Western Society for Clinical Investigation
    Johns Hopkins Hospital1989Visiting Professor
    University of California, San Francisco1995Western Association of Physicians
    UCSF VAMC PRIME Program1997Excellence in Outpatient Teaching Award
    UCSF Pulmonary and Critical Care Medicine Fellowship Program2003Annual Faculty Teaching Award
    UCSF VAMC PRIME Program2011Excellence in Outpatient Teaching Award
    UCSF Department of Medicine2012Member, Council of Master Clinicians
    California Thoracic Society2015Outstanding Clinician Award

    Collapse Overview 
    Collapse Overview
    Dr. Brown obtained his internal medicine and pulmonary training at Johns Hopkins University and UCSF. Beginning in 1981, he served as Assistant or Acting (2002-2004) Chief of Pulmonary, Critical, and Sleep Medicine at the San Francisco VA Medical Center. He was chief of outpatient pulmonary clinics and the pulmonary function laboratory at the VA until 2017 and founded and directed the Sleep Medicine Program until Dr. Sarmiento’s arrival here the same year. He also founded and continues to direct the Lung Cancer Screening Program at the VA. He has had a strong interest in internal medicine resident education and directed a rotation for UCSF medical residents in the chest clinic at the VA from 1995 to 2017. He was VA site director for the UCSF pulmonary fellowship program from 2004 until 2018. He continues to serve as an attending physician on the inpatient pulmonary rotation, chest clinic, and ICU at the VA. He also oversees a weekly Wednesday noon-hour pulmonary clinical conference at the VA and is a member of Dr. Meshell Johnson's Health Equity Council. He has chaired the UCSF Department of Medicine’s Clinical X Search Committee since 2013.

    From 1979 to 2006, Dr. Brown directed a research program focused on regulation of contractile responses, remodeling, and growth of airway smooth muscle cells. More recently, his research has related to implementation of lung cancer screening using low-dose chest CT scans in the VA. He has served as Chair, VA Subcommittee, of American Thoracic Society’s Research Advocacy Committee since 2009. In this role, he advocates for the the VA’s Research and Development Program particularly in areas of improving the research laboratory infrastructure, strengthening the VA Research Career Development Award Program, increasing the visibility of VA-focused sessions at ATS International Conferences, and finding ways to expand access to and effectiveness of lung cancer screening using low-dose chest CT scans in Veterans. He now serves as Chair of ATS’s Research Advocacy Committee. This committee works collaboratively with the National Institutes of Health, the Veterans Administration, the Centers for Disease Control and Prevention, and the Agency for Healthcare Research and Quality to advance research in pulmonary, critical care, and sleep medicine. He is editor of the ATS's Research News Quarterly.

    Collapse Research 
    Collapse Research Activities and Funding
    VA Lung Precision Oncology Program
    VA Research and Development and VA Cooperative Studies Programs, Sunny Wang and Jim Brown, co-PI's Jan 1, 2021 - Dec 31, 2026
    Role: PI in charge of the lung cancer screening portion of the project.
    Description: This is a new VA program for which the principal goal is to enhance research and care in two areas related to lung cancer: precision oncology and lung cancer screening. The award is in the amount of $4.5 million over 5 years. Funds will be allocated approximately equally for precision oncology and lung cancer screening.
    CONNECT:Smoking Cessation and Lung Cancer Screening
    UC Tobacco-Related Disease Research Award. PI: Judith Walsh Jul 1, 2018 - Jun 30, 2021
    Role: Co-Investigator (5% time)
    Circulating Tumor DNA for Risk Stratification in Lung Cancer Screening
    Guardant Health, Inc.: PI: Mehrdad Arjomandi Aug 1, 2017 - Jul 31, 2022
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. National Survey of Lung Cancer Screening Practices in Veterans Health Administration Facilities. Am J Prev Med. 2023 Nov; 65(5):901-905. Núñez ER, Slatore CG, Tanner NT, Melzer AC, Crothers KA, Lewis JA, Fabbrini AE, Brown JK, Wiener RS. PMID: 37169315; PMCID: PMC10592654.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. National Survey of Current Lung Cancer Screening Program Models and Practices in Veterans Health Administration Facilities. American Journal of Preventive Medicine. 2023. Núñez ER, Slatore CG, Tanner NT, MD, Melzer AC, Crothers K, Lewis JA, Fabbrini A, Brown JK, Wiener RS.
    3. Update on Veterans Health Administration’s New Program for Lung Cancer Research and Care. American Thoracic Society’s Research News Quarterly. 2023. Brown, J. K, Klein, M.
    4. Lung Cancer Screening Among U.S. Military Veterans by Health Status and Race and Ethnicity, 2017-2020: A Cross-Sectional Population-Based Study. AJPM Focus. 2023 Jun; 2(2):100084. Rustagi AS, Byers AL, Brown JK, Purcell N, Slatore CG, Keyhani S. PMID: 37790642; PMCID: PMC10546514.
      View in: PubMed   Mentions:
    5. Lung cancer screening among U. S. Veterans by health status and race and ethnicity. 2017-2020: a cross-sectional population-based study. American Journal of Preventive Medicine Focus. 2023. Alison S. Rustagi, Amy L. Byers, James K. Brown, Natalie Purcell, Christopher G. Slatore, and Salomeh Keyhani. .
    6. Development and Validation of a Risk Assessment Model for Pulmonary Nodules Using Plasma Proteins and Clinical Factors. Chest. 2023 04; 163(4):966-976. Vachani A, Lam S, Massion PP, Brown JK, Beggs M, Fish AL, Carbonell L, Wang SX, Mazzone PJ. PMID: 36368616; PMCID: PMC10258433.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Age, comorbidity, life expectancy, and pulmonary nodule follow-up in older veterans. PLoS One. 2018; 13(7):e0200496. Wong ML, Shi Y, Fung KZ, Ngo S, Elicker BM, Brown JK, Hiatt RA, Tang VL, Walter LC. PMID: 30044854; PMCID: PMC6059441.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Tryptase activates phosphatidylinositol 3-kinases proteolytically independently from proteinase-activated receptor-2 in cultured dog airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L259-69. Brown JK, Hollenberg MD, Jones CA. PMID: 16155087.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L197-206. Brown JK, Jones CA, Rooney LA, Caughey GH, Hall IP. PMID: 11792624.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
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