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Thomas Hope, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentRadiology
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 2648
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    Collapse Biography 
    Collapse Awards and Honors
    Prostate Cancer Foundation2017Young Investigator Award
    Society of Nuclear Medicine and Molecular Imaging2016Marc Tetalman Award
    Society of Nuclear Medicine and Molecular Imaging2016Henkin Fellowship
    Society of Abdominal Radiology2014Wylie J. Dodds Research Award
    University of California, San Francisco 2012Alexander Margulis Society Outstanding Research Award
    Radiological Society of North America2012Roentgen Resident/Fellow Research Award
    Radiological Society of North America2010Presidents Circle Research Resident Grant
    ISMRM2007W.S. Moore Award Nominee
    Radiological Society of North America2006Trainee Research Prize

    Collapse Overview 
    Collapse Overview
    Thomas Hope, MD, is an Assistant Professor in Residence in the Abdominal Imaging and Nuclear Medicine sections at UCSF and the San Francisco Veterans Affairs Medical Center. In 2007, he received his medical degree from Stanford University School of Medicine and he completed a one-year internship at Kaiser Permanente, San Francisco. From 2008-2012, Dr. Hope completed a residency in Diagnostic Radiology at the University of California, San Francisco, followed by a clinical fellowship in Body MRI and Nuclear Medicine from Stanford Medical Center in 2013.

    Dr. Hope’s main research focus is on novel imaging agents and therapies. He is the principle investigator on the Ga-68 DOTA-TOC IND at UCSF and the Ga-68 PSMA-11 IND at UCSF. He has combined his interest in MR imaging with PET in the simultaneous modality PET/MRI, helping lead the development of the clinical PET/MRI program. Additionally he is developing the PRRT (peptide receptor radionuclide therapy) program for neuroendocrine tumors at UCSF.

    Dr. Hope has published 60 peer-reviewed articles, including 21 first author publications.

    Expertise:
    Abdominal Imaging and Nuclear Medicine

    Professional Interests:
    Novel imaging agents, PET/MR, prostate cancer, neuroendocrine tumor, targeted radiotherapy

    Education and Training:
    • Medical School: Stanford University School of Medicine, California
    • Internship: Kaiser Permanente, San Francisco, California
    • Residency: University of California, San Francisco - Diagnostic Radiology
    • Fellowship: Stanford Medical Center, California - Body MRI and Nuclear Medicine
    • California Medical License
    • American Board of Radiology, Certificate in Diagnostic Radiology
    • American Board of Nuclear Medicine, Certificate in Nuclear Medicine


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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Leynes AP, Yang J, Wiesinger F, Kaushik SS, Shanbhag DD, Seo Y, Hope T, Larson PEZ. Direct PseudoCT Generation for Pelvis PET/MRI Attenuation Correction using Deep Convolutional Neural Networks with Multi-parametric MRI: Zero Echo-time and Dixon Deep pseudoCT (ZeDD-CT). J Nucl Med. 2017 Oct 30. PMID: 29084824.
      View in: PubMed
    2. Jiang W, Ong F, Johnson KM, Nagle SK, Hope T, Lustig M, Larson PEZ. Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator. Magn Reson Med. 2017 Oct 11. PMID: 29023975.
      View in: PubMed
    3. Lake ST, Greene KL, Westphalen AC, Behr SC, Zagoria R, Small EJ, Carroll PR, Hope T. Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer. EJNMMI Res. 2017 Sep 19; 7(1):77. PMID: 28929350.
      View in: PubMed
    4. Huo E, Wilson DM, Eisenmenger L, Hope T. The Role of PET/MR Imaging in Precision Medicine. PET Clin. 2017 Oct; 12(4):489-501. PMID: 28867118.
      View in: PubMed
    5. Hicks RM, Loening AM, Ohliger MA, Vasanawala SS, Hope T. Variable refocusing flip angle single-shot fast spin echo imaging of liver lesions: increased speed and lesion contrast. Abdom Radiol (NY). 2017 Jul 08. PMID: 28689221.
      View in: PubMed
    6. Fowler KJ, Potretzke TA, Hope T, Costa EA, Wilson SR. LI-RADS M (LR-M): definite or probable malignancy, not specific for hepatocellular carcinoma. Abdom Radiol (NY). 2017 Jun 03. PMID: 28580538.
      View in: PubMed
    7. Fendler WP, Eiber M, Beheshti M, Bomanji J, Ceci F, Cho S, Giesel F, Haberkorn U, Hope T, Kopka K, Krause BJ, Mottaghy FM, Schöder H, Sunderland J, Wan S, Wester HJ, Fanti S, Herrmann K. 68Ga-PSMA PET/CT: Joint EANM and SNMMI procedure guideline for prostate cancer imaging: version 1.0. Eur J Nucl Med Mol Imaging. 2017 Jun; 44(6):1014-1024. PMID: 28283702.
      View in: PubMed
    8. Ohliger MA, Hope T, Chapman JS, Chen LM, Behr SC, Poder L. PET/MR Imaging in Gynecologic Oncology. Magn Reson Imaging Clin N Am. 2017 Aug; 25(3):667-684. PMID: 28668166.
      View in: PubMed
    9. Hope T, Aggarwal R, Chee B, Tao D, Greene KL, Cooperberg M, Feng F, Chang A, Ryan CJ, Small EJ, Carroll PR. Impact of Ga-68 PSMA-11 PET on Management in Patients with Biochemically Recurrent Prostate Cancer. J Nucl Med. 2017 May 18. PMID: 28522741.
      View in: PubMed
    10. Yang J, Wiesinger F, Kaushik S, Shanbhag D, Hope T, Larson PEZ, Seo Y. Evaluation of sinus/edge corrected ZTE-based attenuation correction in brain PET/MRI. J Nucl Med. 2017 May 04. PMID: 28473594.
      View in: PubMed
    11. Hope T, Aslam R, Weinstein S, Yeh BM, Corvera CU, Monto A, Yee J. Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography. J Comput Assist Tomogr. 2017 May/Jun; 41(3):376-381. PMID: 27801693.
      View in: PubMed
    12. Fendler WP, Calais J, Allen-Auerbach M, Bluemel C, Eberhardt N, Emmett L, Gupta P, Hartenbach M, Hope T, Okamoto S, Pfob CH, Pöppel TD, Rischpler C, Schwarzenböck S, Stebner V, Unterrainer M, Zacho HD, Maurer T, Gratzke C, Crispin A, Czernin J, Herrmann K, Eiber M. 68Ga-PSMA-11 PET/CT interobserver agreement for prostate cancer assessments: an international multicenter prospective study. J Nucl Med. 2017 Apr 13. PMID: 28408531.
      View in: PubMed
    13. Yang J, Khalighi M, Hope T, Ordovas K, Seo Y. Technical Note: Fast respiratory motion estimation using sorted singles without unlist processing: A feasibility study. Med Phys. 2017 May; 44(5):1632-1637. PMID: 28099995.
      View in: PubMed
    14. Lawhn-Heath C, Flavell RR, Glastonbury C, Hope T, Behr SC. Incidental Detection of Head and Neck Squamous Cell Carcinoma on 68Ga-PSMA-11 PET/CT. Clin Nucl Med. 2017 Apr; 42(4):e218-e220. PMID: 28166149.
      View in: PubMed
    15. Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PE, Hope T. PET/MRI: Where might it replace PET/CT? J Magn Reson Imaging. 2017 Mar 30. PMID: 28370695.
      View in: PubMed
    16. Leynes AP, Yang J, Shanbhag DD, Kaushik SS, Seo Y, Hope T, Wiesinger F, Larson PE. Hybrid ZTE/Dixon MR-based attenuation correction for quantitative uptake estimation of pelvic lesions in PET/MRI. Med Phys. 2017 Mar; 44(3):902-913. PMID: 28112410.
      View in: PubMed
    17. Ikram NS, Yee J, Weinstein S, Yeh BM, Corvera CU, Monto A, Hope T. Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement. Abdom Radiol (NY). 2017 Mar; 42(3):870-876. PMID: 27770162.
      View in: PubMed
    18. Yang J, Jian Y, Jenkins N, Behr SC, Hope T, Larson PE, Vigneron D, Seo Y. Quantitative Evaluation of Atlas-based Attenuation Correction for Brain PET in an Integrated Time-of-Flight PET/MR Imaging System. Radiology. 2017 Jul; 284(1):169-179. PMID: 28234560.
      View in: PubMed
    19. Kluijfhout WP, Pasternak JD, Gosnell JE, Shen WT, Duh QY, Vriens MR, de Keizer B, Hope T, Glastonbury CM, Pampaloni MH, Suh I. 18F Fluorocholine PET/MR Imaging in Patients with Primary Hyperparathyroidism and Inconclusive Conventional Imaging: A Prospective Pilot Study. Radiology. 2017 Aug; 284(2):460-467. PMID: 28121522.
      View in: PubMed
    20. Kluijfhout WP, Pasternak JD, Beninato T, Drake FT, Gosnell JE, Shen WT, Duh QY, Allen IE, Vriens MR, de Keizer B, Hope T, Suh I. Diagnostic performance of computed tomography for parathyroid adenoma localization; a systematic review and meta-analysis. Eur J Radiol. 2017 Mar; 88:117-128. PMID: 28189196.
      View in: PubMed
    21. Ehman EC, Umetsu SE, Ohliger MA, Fidelman N, Ferrell LD, Yeh BM, Yee J, Hope T, et al. Imaging prediction of residual hepatocellular carcinoma after locoregional therapy in patients undergoing liver transplantation or partial hepatectomy. Abdom Radiol (NY). 2016 Nov; 41(11):2161-2168. PMID: 27484789.
      View in: PubMed
    22. Zukotynski K, Jadvar H, Hope T, Subramaniam RM, Van Loon K, Varma M, Niederkohr RD, et al. SNMMI Comment on the 2016 Society of Surgical Oncology "Choosing Wisely" Recommendation on the Use of PET/CT in Colorectal Cancer. J Nucl Med. 2017 Jan; 58(1):11-12. PMID: 27688471.
      View in: PubMed
    23. Hope T, Truillet CC, Ehman EC, Afshar-Oromieh A, Aggarwal R, Ryan CJ, Carroll PR, Small EJ, Evans MJ. 68Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience. J Nucl Med. 2017 Jan; 58(1):81-84. PMID: 27660139.
      View in: PubMed
    24. Kim SY, Wu EH, Park SH, Wang ZJ, Hope T, Yee J, Zhao LQ, Chang WC, Yeh BM. Comparison of hepatocellular carcinoma conspicuity on hepatobiliary phase images with gadoxetate disodium vs. delayed phase images with extracellular cellular contrast agent. Abdom Radiol (NY). 2016 Aug; 41(8):1522-31. PMID: 26971341.
      View in: PubMed
    25. Hope T, Aggarwal RR, Westphalen AC, Cooperberg MR, Greene KL, et al. Targeted PET imaging for prostate-specific membrane antigen in prostate cancer. Future Oncol. 2016 Nov; 12(21):2393-2396. PMID: 27453303.
      View in: PubMed
    26. Kluijfhout WP, Venkatesh S, Beninato T, Vriens MR, Duh QY, Wilson DM, Hope T, Suh I. Performance of magnetic resonance imaging in the evaluation of first-time and reoperative primary hyperparathyroidism. Surgery. 2016 Sep; 160(3):747-54. PMID: 27318765.
      View in: PubMed
    27. Afshar-Oromieh A, Hetzheim H, Kübler W, Kratochwil C, Giesel FL, Hope T, Eder M, Eisenhut M, Kopka K, Haberkorn U. Radiation dosimetry of (68)Ga-PSMA-11 (HBED-CC) and preliminary evaluation of optimal imaging timing. Eur J Nucl Med Mol Imaging. 2016 Aug; 43(9):1611-20. PMID: 27260521.
      View in: PubMed
    28. Ehman EC, Behr SC, Umetsu SE, Fidelman N, Yeh BM, Ferrell LD, Hope T. Rate of observation and inter-observer agreement for LI-RADS major features at CT and MRI in 184 pathology proven hepatocellular carcinomas. Abdom Radiol (NY). 2016 May; 41(5):963-9. PMID: 27193793.
      View in: PubMed
    29. Hicks RM, Yee J, Ohliger MA, Weinstein S, Kao J, Ikram NS, Hope T. Comparison of diffusion-weighted imaging and T2-weighted single shot fast spin-echo: Implications for LI-RADS characterization of hepatocellular carcinoma. Magn Reson Imaging. 2016 Sep; 34(7):915-21. PMID: 27108359.
      View in: PubMed
    30. Becker-Weidman DJ, Hope T, Doshi PH, Patel A, Mitchell DG. Transient washout of hepatic hemangiomas: Potential pitfall mimicking malignancy. Radiol Case Rep. 2016 Jun; 11(2):62-6. PMID: 27257451; PMCID: PMC4878935.
    31. Vasanawala SS, Nguyen KL, Hope MD, Bridges MD, Hope T, Reeder SB, Bashir MR. Safety and technique of ferumoxytol administration for MRI. Magn Reson Med. 2016 May; 75(5):2107-11. PMID: 26890830; PMCID: PMC4854636.
    32. Hope T, Verdin EF, Bergsland EK, Ohliger MA, Corvera CU, Nakakura EK. Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging. EJNMMI Phys. 2015 Dec; 2(1):21. PMID: 26501822; PMCID: PMC4573645.
    33. Hope T, Petkovska I, Saranathan M, Hargreaves BA, Vasanawala SS. Combined parenchymal and vascular imaging: High spatiotemporal resolution arterial evaluation of hepatocellular carcinoma. J Magn Reson Imaging. 2016 Apr; 43(4):859-65. PMID: 26340309.
      View in: PubMed
    34. Hope T, Pampaloni MH, Nakakura E, VanBrocklin H, Slater J, Jivan S, Aparici CM, Yee J, Bergsland E. Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor. Abdom Imaging. 2015 Aug; 40(6):1432-40. PMID: 25820755.
      View in: PubMed
    35. Burris NS, Johnson KM, Larson PE, Hope MD, Nagle SK, Behr SC, Hope T. Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MR System. Radiology. 2016 Jan; 278(1):239-46. PMID: 26133050; PMCID: PMC4699498 [Available on 01/01/17].
    36. Hope MD, Hope T, Zhu C, Faraji F, Haraldsson H, Ordovas KG, Saloner D. Vascular Imaging With Ferumoxytol as a Contrast Agent. AJR Am J Roentgenol. 2015 Sep; 205(3):W366-73. PMID: 26102308.
      View in: PubMed
    37. Hope T, Aggarwal R, Simko JP, VanBrocklin HF, Ryan CJ. Somatostatin imaging of neuroendocrine-differentiated prostate cancer. Clin Nucl Med. 2015 Jun; 40(6):540-1. PMID: 25783510.
      View in: PubMed
    38. Kim SY, Park SH, Wu EH, Wang ZJ, Hope T, Chang WC, Yeh BM. Transient respiratory motion artifact during arterial phase MRI with gadoxetate disodium: risk factor analyses. AJR Am J Roentgenol. 2015 Jun; 204(6):1220-7. PMID: 26001231.
      View in: PubMed
    39. Stephens EH, Hope T, Kari FA, Kvitting JP, Liang DH, Herfkens RJ, Miller DC. Greater asymmetric wall shear stress in Sievers' type 1/LR compared with 0/LAT bicuspid aortic valves after valve-sparing aortic root replacement. J Thorac Cardiovasc Surg. 2015 Jul; 150(1):59-68. PMID: 25956338.
      View in: PubMed
    40. Hope T, Fowler KJ, Sirlin CB, Costa EA, Yee J, Yeh BM, Heiken JP. Hepatobiliary agents and their role in LI-RADS. Abdom Imaging. 2015 Mar; 40(3):613-25. PMID: 25287679.
      View in: PubMed
    41. Jacobs MA, Weinstein S, Hope T, Aslam R, Yee J, Coakley F. Neuroendocrine tumors: beyond the abdomen. J Comput Assist Tomogr. 2014 Nov-Dec; 38(6):898-914. PMID: 25162290.
      View in: PubMed
    42. Hope T, Ohliger MA, Qayyum A. MR imaging of diffuse liver disease: from technique to diagnosis. Radiol Clin North Am. 2014 Jul; 52(4):709-24. PMID: 24889168.
      View in: PubMed
    43. Hope MD, Hope T. Functional and molecular imaging techniques in aortic aneurysm disease. Curr Opin Cardiol. 2013 Nov; 28(6):609-18. PMID: 24030165.
      View in: PubMed
    44. Hope TA, Kvitting JP, Hope T, Miller DC, Markl M, Herfkens RJ. Evaluation of Marfan patients status post valve-sparing aortic root replacement with 4D flow. Magn Reson Imaging. 2013 Nov; 31(9):1479-84. PMID: 23706513.
      View in: PubMed
    45. Hope T, Saranathan M, Petkovska I, Hargreaves BA, Herfkens RJ, Vasanawala SS. Improvement of gadoxetate arterial phase capture with a high spatio-temporal resolution multiphase three-dimensional SPGR-Dixon sequence. J Magn Reson Imaging. 2013 Oct; 38(4):938-45. PMID: 23371926.
      View in: PubMed
    46. Durack JC, Hope T, Seo Y, Saeed M, He J, Wilson MW, Kerlan RK, Ring EJ. Intravenous vasopressin for the prevention of nontarget gastrointestinal embolization during liver-directed cancer treatment: experimental study in a porcine model. J Vasc Interv Radiol. 2012 Nov; 23(11):1505-12. PMID: 22974656.
      View in: PubMed
    47. Hope T, Leboit PE, High WA, Fu Y, Brasch RC. Evaluation of imatinib mesylate as a possible treatment for nephrogenic systemic fibrosis in a rat model. Magn Reson Imaging. 2013 Jan; 31(1):139-44. PMID: 22898683.
      View in: PubMed
    48. Hope T, Doherty A, Fu Y, Aslam R, Qayyum A, Brasch RC. Gadolinium accumulation and fibrosis in the liver after administration of gadoxetate disodium in a rat model of active hepatic fibrosis. Radiology. 2012 Aug; 264(2):423-7. PMID: 22570507.
      View in: PubMed
    49. Hope TA, Hope T. Improved risk assessment for abdominal aortic aneurysm rupture: off-the-wall imaging. J Am Coll Cardiol. 2011 Dec 06; 58(24):2531-2. PMID: 22133854.
      View in: PubMed
    50. Hope MD, Hope T, Crook SE, Ordovas KG, Urbania TH, Alley MT, Higgins CB. 4D flow CMR in assessment of valve-related ascending aortic disease. JACC Cardiovasc Imaging. 2011 Jul; 4(7):781-7. PMID: 21757170.
      View in: PubMed
    51. McGowan PO, Hope T, Meck WH, Kelsoe G, Williams CL. Impaired social recognition memory in recombination activating gene 1-deficient mice. Brain Res. 2011 Apr 06; 1383:187-95. PMID: 21354115; PMCID: PMC3436067.
    52. Hope MD, Hope T, Urbania TH, Higgins CB. Four-dimensional flow magnetic resonance imaging with wall shear stress analysis before and after repair of aortopulmonary fistula. Circ Cardiovasc Imaging. 2010 Nov; 3(6):766-8. PMID: 21081744.
      View in: PubMed
    53. Hope MD, Hope T, Meadows AK, Ordovas KG, Urbania TH, Alley MT, Higgins CB. Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns. Radiology. 2010 Apr; 255(1):53-61. PMID: 20308444.
      View in: PubMed
    54. Hope MD, Meadows AK, Hope T, Ordovas KG, Saloner D, Reddy GP, Alley MT, Higgins CB. Clinical evaluation of aortic coarctation with 4D flow MR imaging. J Magn Reson Imaging. 2010 Mar; 31(3):711-8. PMID: 20187217.
      View in: PubMed
    55. Hope T, High WA, Leboit PE, Chaopathomkul B, Rogut VS, Herfkens RJ, Brasch RC. Nephrogenic systemic fibrosis in rats treated with erythropoietin and intravenous iron. Radiology. 2009 Nov; 253(2):390-8. PMID: 19789237.
      View in: PubMed
    56. Cebral JR, Putman CM, Alley MT, Hope T, Bammer R, Calamante F. Hemodynamics in Normal Cerebral Arteries: Qualitative Comparison of 4D Phase-Contrast Magnetic Resonance and Image-Based Computational Fluid Dynamics. J Eng Math. 2009 Aug 01; 64(4):367-378. PMID: 19684874.
      View in: PubMed
    57. Hope TA, Hope T, Purcell DD, von Morze C, Vigneron DB, Alley MT, Dillon WP. Evaluation of intracranial stenoses and aneurysms with accelerated 4D flow. Magn Reson Imaging. 2010 Jan; 28(1):41-6. PMID: 19577400.
      View in: PubMed
    58. Hope T, Herfkens RJ, Denianke KS, LeBoit PE, Hung YY, Weil E. Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine. Invest Radiol. 2009 Mar; 44(3):135-9. PMID: 19151610.
      View in: PubMed
    59. Hope T, Zarins CK, Herfkens RJ. Initial experience characterizing a type I endoleak from velocity profiles using time-resolved three-dimensional phase-contrast MRI. J Vasc Surg. 2009 Jun; 49(6):1580-4. PMID: 19223146.
      View in: PubMed
    60. Hope MD, Purcell DD, Hope T, von Morze C, Vigneron DB, Alley MT, Dillon WP. Complete intracranial arterial and venous blood flow evaluation with 4D flow MR imaging. AJNR Am J Neuroradiol. 2009 Feb; 30(2):362-6. PMID: 18653687.
      View in: PubMed
    61. Hope MD, Meadows AK, Hope T, Ordovas KG, Reddy GP, Alley MT, Higgins CB. Images in cardiovascular medicine. Evaluation of bicuspid aortic valve and aortic coarctation with 4D flow magnetic resonance imaging. Circulation. 2008 May 27; 117(21):2818-9. PMID: 18506021.
      View in: PubMed
    62. Hope T, Herfkens RJ. Imaging of the thoracic aorta with time-resolved three-dimensional phase-contrast MRI: a review. Semin Thorac Cardiovasc Surg. 2008; 20(4):358-64. PMID: 19251177.
      View in: PubMed
    63. Hope T, Markl M, Wigström L, Alley MT, Miller DC, Herfkens RJ. Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping. J Magn Reson Imaging. 2007 Dec; 26(6):1471-9. PMID: 17968892.
      View in: PubMed
    64. Bammer R, Hope T, Aksoy M, Alley MT. Time-resolved 3D quantitative flow MRI of the major intracranial vessels: initial experience and comparative evaluation at 1.5T and 3.0T in combination with parallel imaging. Magn Reson Med. 2007 Jan; 57(1):127-40. PMID: 17195166; PMCID: PMC3985842.
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