Julius Guccione, PhD

Title(s)Professor Emeritus, Surgery
SchoolSchool of Medicine
Address533 Parnassus Avenue, #158
San Francisco CA 94117
Phone415-680-6285
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    Collapse Biography 
    Collapse Education and Training
    Tulane University B.S.05/1985Biomedical Engineering
    UCSDM.S.06/1987Engineering Sciences (Bioengineering)
    UCSDPh.D.06/1990Engineering Sciences (Bioengineering)
    Johns Hopkins UniversityPostdoctoral Training07/1993Biomedical Engineering
    Collapse Awards and Honors
    University of California, San Diego, CA1985  - 1990Institutional National Research Service Award
    Johns Hopkins University, Baltimore, MD1990  - 1991Institutional National Research Service Award
    1991  - 1993Individual National Research Service Award of the NIH
    1999Richard Skalak Best Paper Award of the ASME Bioengineering Division
    American Institute for Medical and Biological Engineering (AIMBE) College of Fellows2019AIMBE Fellow

    Collapse Overview 
    Collapse Overview
    Julius M. Guccione, Ph.D. is Professor Emeritus in the UCSF Department of Surgery, specializing in realistic simulation of the efficacy of novel surgical procedures and devices for treating ischemic cardiomyopathy. He graduated with a B.S. in Biomedical Engineering from Tulane University. He obtained his M.S. and Ph.D. in Bioengineering from UCSD. He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University.

    Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. In 2012, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction.

    Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function.

    Dr. Guccione also is CTO at 3DT HOLDINGS, LLC

    Collapse Research 
    Collapse Research Activities and Funding
    Software Tool for Optimization of CRT
    NIH/NHLBI R43HL174177Apr 1, 2024 - Dec 31, 2024
    Role: Principal Investigator
    Software-guided Operative Planning of MitraClip Placement
    NIH/NHLBI R44HL169034Dec 1, 2023 - May 31, 2026
    Role: Principal Investigator
    Real-Time Virtual Assessment of MitraClip Placement
    NIH/NHLBI R43HL145896Aug 15, 2019 - Jul 31, 2022
    Role: Consultant (Initiator)
    Multi-Scale Laws of Myocardial Growth and Remodeling
    NIH U01HL119578Jul 25, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure
    NIH R01HL118627Sep 1, 2013 - Jun 30, 2019
    Role: Principal Investigator
    Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration
    NIH R01HL086400Aug 15, 2009 - Jul 31, 2011
    Role: Principal Investigator
    VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERY
    NIH R01HL077921Apr 15, 2006 - Jul 31, 2018
    Role: Principal Investigator
    Quantitative analysis of left ventriculoplasty: CHF
    NIH R01HL063348Apr 17, 2000 - Apr 30, 2020
    Role: Co-Investigator
    REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    NIH R01HL058759Sep 1, 1997 - Aug 31, 2001
    Role: Principal Investigator
    Regional Mechanical Properties of Intact Ventricular Muscle
    The Whitaker Foundation Biomedical Engineering Research GrantAug 1, 1994 - Jul 31, 1997
    Role: Principal Investigator
    VENTRICULAR MUSCLE MECHANICS UNDER PHYSIOLOGICAL LOADING
    NIH F32HL008492Dec 20, 1991
    Role: Principal Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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      Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
      1. Temporal Evolution of Ascending Aortic Aneurysm Wall Stress Predicts All-Cause Mortality. Interdiscip Cardiovasc Thorac Surg. 2024 Jun 24. Zamirpour S, Gulati A, Xuan Y, Leach JR, Saloner DA, Guccione JM, Boskovski MK, Ge L, Tseng EE. PMID: 38913870.
        View in: PubMed   Mentions:    Fields:    
      2. Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm. Int J Cardiol Heart Vasc. 2024 Apr; 51:101375. Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach JR, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 38435381; PMCID: PMC10909604.
        View in: PubMed   Mentions:
      3. Imaging and Computational Modeling of Tricuspid Regurgitation and Repair. Vessel Plus. 2023. Morgan AE, Howell K, Chen S, Serrone RO, Zhang Y, Wang VY, Kim JJ, Grossi E, Selzman CH, Guccione JM, Sharma V, MacLeod R; Ratcliffe MB. View Publication.
      4. A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation. JACC: ADVANCES. 2023. Dabiri Y, Mahadevan V, Guccione JM, Kassab GS. View Publication.
      5. On the Role of Ionic Model in the Signature of Cardiac Arrhythmias for Healthy and Diseased Hearts. Mathematics. 2023. Ramirez WA, Gizzi A, Sack KL, Filippi S, Guccione JM, Hurtado DE. View Publication.
      6. On the Severity of Aortic Stenosis in Ascending Aortic Aneurysm A Computational Tool to Examine Ventricular-Arterial Interaction and Aortic Wall Stress. Mechanics Research Communications. 2023. Cosentino F, Giuseppe M, Agnese V, Gentile G, Raffa GM, Wisneski A, Guccione J, Pilato M, Pasta S. View Publication.
      7. Aortic area/height ratio, peak wall stresses, and outcomes in veterans with tricuspid versus bicuspid aortic valve-associated ascending thoracic aortic aneurysms. J Thorac Cardiovasc Surg. 2023 12; 166(6):1583-1593.e2. Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 37295642.
        View in: PubMed   Mentions: 2     Fields:    Translation:Humans
      8. Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population. Eur J Cardiothorac Surg. 2023 06 01; 63(6). Gulati A, Zamirpour S, Leach J, Khan A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 37354525; PMCID: PMC10301688.
        View in: PubMed   Mentions: 2     Fields:    Translation:Humans
      9. Looking towards the future: patient-specific computational modeling to optimize outcomes for transcatheter mitral valve repair. Front Cardiovasc Med. 2023; 10:1140379. Wong P, Wisneski AD, Sandhu A, Wang Z, Mahadevan VS, Nguyen TC, Guccione JM. PMID: 37168656; PMCID: PMC10164975.
        View in: PubMed   Mentions:
      10. Machine learning used for simulation of MitraClip intervention: A proof-of-concept study. Front Genet. 2023; 14:1142446. Dabiri Y, Mahadevan VS, Guccione JM, Kassab GS. PMID: 36968590; PMCID: PMC10033889.
        View in: PubMed   Mentions: 1  
      11. Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients. Sci Rep. 2023 01 18; 13(1):958. Mojumder J, Fan L, Nguyen T, Campbell KS, Wenk JF, Guccione JM, Abraham T, Lee LC. PMID: 36653468; PMCID: PMC9849405.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      12. Regional and directional delamination properties of healthy human ascending aorta and sinotubular junction. J Mech Behav Biomed Mater. 2023 02; 138:105603. Xuan Y, Wang Z, Guccione JM, Tseng EE, Ge L. PMID: 36512974.
        View in: PubMed   Mentions:    Fields:    Translation:Humans
      13. Numerical simulation of transcatheter mitral valve replacement: The dynamic implication of LVOT obstruction in the valve-in-ring case. J Biomech. 2022 11; 144:111337. Pasta S, Catalano C, Cannata S, Guccione JM, Gandolfo C. PMID: 36209656.
        View in: PubMed   Mentions: 2     Fields:    Translation:Humans
      14. A Computationally Efficient Approach to Simulate Heart Rate Effects Using a Whole Human Heart Model. Bioengineering (Basel). 2022 Jul 24; 9(8). Yao J, Chen S, Guccione JM. PMID: 35892747; PMCID: PMC9331290.
        View in: PubMed   Mentions:
      15. Association of 3-Year All-Cause Mortality and Peak Wall Stresses of Ascending Thoracic Aortic Aneurysms in Veterans. Semin Thorac Cardiovasc Surg. 2023 Autumn; 35(3):447-456. Zamirpour S, Xuan Y, Wang Z, Gomez A, Hope MD, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 35690227.
        View in: PubMed   Mentions: 2     Fields:    
      16. Regional wall stress differences on tricuspid aortic valve-associated ascending aortic aneurysms. Interact Cardiovasc Thorac Surg. 2022 06 01; 34(6):1115-1123. Gomez A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 34718581; PMCID: PMC10634398.
        View in: PubMed   Mentions: 1     Fields:    Translation:Humans
      17. Inversion of Left Atrial Appendage Will Cause Compressive Stresses in the Tissue: Simulation Study of Potential Therapy. J Pers Med. 2022 May 27; 12(6). Pasta S, Guccione JM, Kassab GS. PMID: 35743668; PMCID: PMC9225454.
        View in: PubMed   Mentions: 4  
      18. Left Ventricle Biomechanics of Low-Flow, Low-Gradient Aortic Stenosis: A Patient-Specific Computational Model. Front Physiol. 2022; 13:848011. Wisneski AD, Wang Y, Cutugno S, Pasta S, Stroh A, Yao J, Nguyen TC, Mahadevan VS, Guccione JM. PMID: 35464089; PMCID: PMC9019780.
        View in: PubMed   Mentions: 2  
      19. A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation. JACC Adv. 2022 Mar; 1(1):100015. Dabiri Y, Mahadevan VS, Guccione JM, Kassab GS. PMID: 38939090; PMCID: PMC11198285.
        View in: PubMed   Mentions:
      20. Mitral Valve Atlas for Artificial Intelligence Predictions of MitraClip Intervention Outcomes. Front Cardiovasc Med. 2021; 8:759675. Dabiri Y, Yao J, Mahadevan VS, Gruber D, Arnaout R, Gentzsch W, Guccione JM, Kassab GS. PMID: 34957251; PMCID: PMC8709129.
        View in: PubMed   Mentions: 5  
      21. Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model. Bioengineering (Basel). 2021 Nov 04; 8(11). Cutugno S, Agnese V, Gentile G, Raffa GM, Wisneski AD, Guccione JM, Pilato M, Pasta S. PMID: 34821741; PMCID: PMC8615119.
        View in: PubMed   Mentions: 2  
      22. Regional biomechanical and failure properties of healthy human ascending aorta and root. J Mech Behav Biomed Mater. 2021 11; 123:104705. Xuan Y, Wisneski AD, Wang Z, Lum M, Kumar S, Pallone J, Flores N, Inman J, Lai L, Lin J, Guccione JM, Tseng EE, Ge L. PMID: 34454207; PMCID: PMC8513753.
        View in: PubMed   Mentions: 11     Fields:    Translation:Humans
      23. Association of diameter and wall stresses of tricuspid aortic valve ascending thoracic aortic aneurysms. J Thorac Cardiovasc Surg. 2022 11; 164(5):1365-1375. Gomez A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 34275618; PMCID: PMC8716675.
        View in: PubMed   Mentions: 5     Fields:    Translation:Humans
      24. A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction. Magn Reson Med. 2021 10; 86(4):2105-2121. Wang VY, Tartibi M, Zhang Y, Selvaganesan K, Haraldsson H, Auger DA, Faraji F, Spaulding K, Takaba K, Collins A, Aguayo E, Saloner D, Wallace AW, Weinsaft JW, Epstein FH, Guccione J, Ge L, Ratcliffe MB. PMID: 34096083.
        View in: PubMed   Mentions:    Fields:    Translation:Animals
      25. Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction. J Cardiovasc Transl Res. 2021 12; 14(6):1131-1145. Shavik SM, Wall S, Sundnes J, Guccione JM, Sengupta P, Solomon SD, Burkhoff D, Lee LC. PMID: 33928526; PMCID: PMC9305326.
        View in: PubMed   Mentions: 14     Fields:    Translation:Humans
      26. Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain. J Mech Behav Biomed Mater. 2021 07; 119:104431. Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB. PMID: 33930653.
        View in: PubMed   Mentions: 9     Fields:    Translation:Humans
      27. Precision medicine in human heart modeling : Perspectives, challenges, and opportunities. Biomech Model Mechanobiol. 2021 Jun; 20(3):803-831. Peirlinck M, Costabal FS, Yao J, Guccione JM, Tripathy S, Wang Y, Ozturk D, Segars P, Morrison TM, Levine S, Kuhl E. PMID: 33580313; PMCID: PMC8154814.
        View in: PubMed   Mentions: 42     Fields:    Translation:Humans
      28. Application of feed forward and recurrent neural networks in simulation of left ventricular mechanics. Sci Rep. 2020 12 18; 10(1):22298. Dabiri Y, Van der Velden A, Sack KL, Choy JS, Guccione JM, Kassab GS. PMID: 33339836; PMCID: PMC7749109.
        View in: PubMed   Mentions: 4     Fields:    Translation:Humans
      29. Impact of Transcatheter Aortic Valve Size on Leaflet Stresses: Implications for Durability and Optimal Grey Zone Sizing. AsiaIntervention. 2020 Dec; 6(2):64-71. Xuan Y, Dvir D, Wisneski AD, Wang Z, Ye J, Guccione JM, Ge L, Tseng EE. PMID: 34708162; PMCID: PMC8525718.
        View in: PubMed   Mentions: 5  
      30. Commentary: Fast and accurate surrogate of finite-element analysis: For bench to bedside, we need it now! JTCVS Tech. 2020 Dec; 4:48-49. Wisneski AD, Guccione JM. PMID: 34317962; PMCID: PMC8308617.
        View in: PubMed   Mentions:
      31. Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation. Front Physiol. 2020; 11:574211. Wisneski AD, Wang Y, Deuse T, Hill AC, Pasta S, Sack KL, Yao J, Guccione JM. PMID: 33013489; PMCID: PMC7506067.
        View in: PubMed   Mentions: 9  
      32. In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy. Sci Rep. 2020 07 31; 10(1):12990. Ramírez WA, Gizzi A, Sack KL, Guccione JM, Hurtado DE. PMID: 32737400; PMCID: PMC7395773.
        View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
      33. Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep. PLoS One. 2020; 15(6):e0234896. Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB. PMID: 32569290; PMCID: PMC7307770.
        View in: PubMed   Mentions: 2     Fields:    Translation:Animals
      34. Stent and leaflet stresses across generations of balloon-expandable transcatheter aortic valves. Interact Cardiovasc Thorac Surg. 2020 06 01; 30(6):879-886. Xuan Y, Dvir D, Wang Z, Ye J, Guccione JM, Ge L, Tseng EE. PMID: 32248231; PMCID: PMC7248644.
        View in: PubMed   Mentions: 3     Fields:    Translation:Humans
      35. Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine. Acta Biomater. 2020 07 15; 111:170-180. Sack KL, Aliotta E, Choy JS, Ennis DB, Davies NH, Franz T, Kassab GS, Guccione JM. PMID: 32428678; PMCID: PMC7368390.
        View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
      36. A Novel MRI-Based Finite Element Modeling Method for Calculation of Myocardial Ischemia Effect in Patients With Functional Mitral Regurgitation. Front Physiol. 2020; 11:158. Zhang Y, Wang VY, Morgan AE, Kim J, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. PMID: 32231584; PMCID: PMC7082816.
        View in: PubMed   Mentions: 2  
      37. Wall Stress Distribution in Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysms. Ann Thorac Surg. 2020 09; 110(3):807-814. Gomez A, Wang Z, Xuan Y, Wisneski AD, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 32006475; PMCID: PMC8598319.
        View in: PubMed   Mentions: 10     Fields:    Translation:Humans
      38. Wall stress analyses in patients with ≥5 cm versus <5 cm ascending thoracic aortic aneurysm. J Thorac Cardiovasc Surg. 2021 11; 162(5):1452-1459. Wang Z, Flores N, Lum M, Wisneski AD, Xuan Y, Inman J, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 32178922; PMCID: PMC8589466.
        View in: PubMed   Mentions: 12     Fields:    Translation:Humans
      39. Numerical Simulations of MitraClip Placement: Clinical Implications. Sci Rep. 2019 11 01; 9(1):15823. Kamakoti R, Dabiri Y, Wang DD, Guccione J, Kassab GS. PMID: 31676753; PMCID: PMC6825188.
        View in: PubMed   Mentions: 7     Fields:    Translation:Humans
      40. Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study. PLoS One. 2019; 14(10):e0223472. Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS, Levine RA, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB. PMID: 31600276; PMCID: PMC6786765.
        View in: PubMed   Mentions: 14     Fields:    Translation:Animals
      41. Editorial: Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic. Front Physiol. 2019; 10:1259. Kassab G, Guccione J. PMID: 31611822; PMCID: PMC6777015.
        View in: PubMed   Mentions: 3  
      42. Prediction of Left Ventricular Mechanics Using Machine Learning. Front Phys. 2019 Sep; 7. Dabiri Y, Van der Velden A, Sack KL, Choy JS, Kassab GS, Guccione JM. PMID: 31903394; PMCID: PMC6941671.
        View in: PubMed   Mentions: 16  
      43. Method for Calibration of Left Ventricle Material Properties Using Three-Dimensional Echocardiography Endocardial Strains. J Biomech Eng. 2019 Sep 01; 141(9). Dabiri Y, Sack KL, Rebelo N, Wang P, Wang Y, Choy JS, Kassab GS, Guccione JM. PMID: 31294752; PMCID: PMC6826696.
        View in: PubMed   Mentions: 6     Fields:    
      44. Finite elastic wrinkling deformations of incompressible fiber-reinforced plates. Int J Eng Sci. 2019 Nov; 144. Taylor M, Shirani M, Dabiri Y, Guccione JM, Steigmann DJ. PMID: 32063652; PMCID: PMC7020621.
        View in: PubMed   Mentions: 1  
      45. Using machine learning to characterize heart failure across the scales. Biomech Model Mechanobiol. 2019 Dec; 18(6):1987-2001. Peirlinck M, Sahli Costabal F, Sack KL, Choy JS, Kassab GS, Guccione JM, De Beule M, Segers P, Kuhl E. PMID: 31240511.
        View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
      46. Tricuspid Valve Regurgitation Decreases after MitraClip Implantation: Fluid Structure Interaction Simulation. Mech Res Commun. 2019 Apr; 97:96-100. Dabiri Y, Yao J, Sack KL, Kassab GS, Guccione JM. PMID: 31439968; PMCID: PMC6706066.
        View in: PubMed   Mentions: 10  
      47. Reply to Letter to Editor by S Tong, L Zhang, J Joseph, and X Jiang "A potential and novel therapeutic approach to ischemic heart failure: Algisyl-LVR". Int J Cardiol. 2019 03 15; 279:133. Kassab GS, Choy JS, Guccione JM. PMID: 30704644.
        View in: PubMed   Mentions:    Fields:    Translation:Animals
      48. Multiscale characterization of heart failure. Acta Biomater. 2019 03 01; 86:66-76. Sahli Costabal F, Choy JS, Sack KL, Guccione JM, Kassab GS, Kuhl E. PMID: 30630123; PMCID: PMC6369012.
        View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
      49. Intramyocardial Injections to De-Stiffen the Heart: A Subject-Specific in Silico Approach. Mol Cell Biomech. 2019; 16(3):185-197. Dabiri Y, Sack KL, Shaul S, Acevedo-Bolton G, Choy JS, Kassab GS, Guccione JM. PMID: 32063808; PMCID: PMC7020624.
        View in: PubMed   Mentions: 4     Fields:    
      50. Range of Pulmonary Autograft Responses to Systemic Pressure Immediately After Ross Procedure. J Heart Valve Dis. 2019; 28(1):22-31. Wisneski AD, Wang Z, Xuan Y, Guccione JM, Ge L, Tseng EE. PMID: 34785871; PMCID: PMC8592523.
        View in: PubMed   Mentions:    Fields:    
      51. Diffusion and swelling in a bio-elastic cylinder. Mech Res Commun. 2019 Apr; 97:123-128. Tartibi M, Guccione JM, Steigmann DJ. PMID: 31379398; PMCID: PMC6677259.
        View in: PubMed   Mentions:
      52. Relationship of Transmural Variations in Myofiber Contractility to Left Ventricular Ejection Fraction: Implications for Modeling Heart Failure Phenotype With Preserved Ejection Fraction. Front Physiol. 2018; 9:1003. Dabiri Y, Sack KL, Shaul S, Sengupta PP, Guccione JM. PMID: 30197595; PMCID: PMC6117406.
        View in: PubMed   Mentions: 15  
      53. Effect of intra-myocardial Algisyl-LVR™ injectates on fibre structure in porcine heart failure. J Mech Behav Biomed Mater. 2018 11; 87:172-179. Sack KL, Aliotta E, Choy JS, Ennis DB, Davies NH, Franz T, Kassab GS, Guccione JM. PMID: 30071487; PMCID: PMC6249033.
        View in: PubMed   Mentions: 7     Fields:    Translation:Animals
      54. Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI. Front Physiol. 2018; 9:539. Sack KL, Aliotta E, Ennis DB, Choy JS, Kassab GS, Guccione JM, Franz T. PMID: 29896107; PMCID: PMC5986944.
        View in: PubMed   Mentions: 24  
      55. Stent and leaflet stresses in 26-mm, third-generation, balloon-expandable transcatheter aortic valve. J Thorac Cardiovasc Surg. 2019 02; 157(2):528-536. Xuan Y, Dvir D, Wang Z, Mizoguchi T, Ye J, Guccione JM, Ge L, Tseng EE. PMID: 30041923; PMCID: PMC8505215.
        View in: PubMed   Mentions: 10     Fields:    Translation:Humans
      56. Investigating the Role of Interventricular Interdependence in Development of Right Heart Dysfunction During LVAD Support: A Patient-Specific Methods-Based Approach. Front Physiol. 2018; 9:520. Sack KL, Dabiri Y, Franz T, Solomon SD, Burkhoff D, Guccione JM. PMID: 29867563; PMCID: PMC5962934.
        View in: PubMed   Mentions: 22  
      57. Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine. Int J Cardiol. 2018 Mar 15; 255:129-135. Choy JS, Leng S, Acevedo-Bolton G, Shaul S, Fu L, Guo X, Zhong L, Guccione JM, Kassab GS. PMID: 29425550; PMCID: PMC6211293.
        View in: PubMed   Mentions: 13     Fields:    Translation:Animals
      58. Wall stress on ascending thoracic aortic aneurysms with bicuspid compared with tricuspid aortic valve. J Thorac Cardiovasc Surg. 2018 08; 156(2):492-500. Xuan Y, Wang Z, Liu R, Haraldsson H, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng E. PMID: 29656820; PMCID: PMC8447844.
        View in: PubMed   Mentions: 16     Fields:    Translation:Humans
      59. Ischemic Mitral Regurgitation: Abnormal Strain Overestimates Nonviable Myocardium. Ann Thorac Surg. 2018 06; 105(6):1754-1761. Morgan AE, Zhang Y, Tartibi M, Goldburg S, Kim JJ, Nguyen TD, Guccione J, Ge L, Weinsaft JW, Ratcliffe MB. PMID: 29391146; PMCID: PMC6005393.
        View in: PubMed   Mentions: 5     Fields:    Translation:Humans
      60. Impact of Patient-Specific Material Properties on Aneurysm Wall Stress: Finite Element Study. J Heart Valve Dis. 2018; 27(5):275-284. Wang Z, Xuan Y, Guccione JM, Tseng EE, Ge L. PMID: 34789967; PMCID: PMC8593768.
        View in: PubMed   Mentions: 7     Fields:    
      61. Stent and Leaflet Stresses in 29-mm Second-Generation Balloon-Expandable Transcatheter Aortic Valve. Ann Thorac Surg. 2017 Sep; 104(3):773-781. Xuan Y, Krishnan K, Ye J, Dvir D, Guccione JM, Ge L, Tseng EE. PMID: 28410636; PMCID: PMC5839641.
        View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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      81. Patient-specific finite element analysis of ascending thoracic aortic aneurysm. J Heart Valve Dis. 2014 Nov; 23(6):765-72. Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE. PMID: 25790625; PMCID: PMC5127264.
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      82. Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis. Ann Thorac Surg. 2014 Oct; 98(4):1355-62. Pantoja JL, Ge L, Zhang Z, Morrel WG, Guccione JM, Grossi EA, Ratcliffe MB. PMID: 25130075; PMCID: PMC6051352.
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      84. Bioinjection treatment: effects of post-injection residual stress on left ventricular wall stress. J Biomech. 2014 Sep 22; 47(12):3115-9. Lee LC, Wall ST, Genet M, Hinson A, Guccione JM. PMID: 25065728; PMCID: PMC4163117.
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      85. A computational model that predicts reverse growth in response to mechanical unloading. Biomech Model Mechanobiol. 2015 Apr; 14(2):217-29. Lee LC, Genet M, Acevedo-Bolton G, Ordovas K, Guccione JM, Kuhl E. PMID: 24888270; PMCID: PMC4254895.
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      87. Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function. Med Biol Eng Comput. 2014 Jun; 52(6):557-66. Lee LC, Ge L, Zhang Z, Pease M, Nikolic SD, Mishra R, Ratcliffe MB, Guccione JM. PMID: 24793158; PMCID: PMC4118670.
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      88. Human pulmonary autograft wall stress at systemic pressures prior to remodeling after the Ross procedure. J Heart Valve Dis. 2014 May; 23(3):377-84. Wisneski AD, Matthews PB, Azadani AN, Mookhoek A, Chitsaz S, Guccione JM, Ge L, Tseng EE. PMID: 25296465.
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      89. Applications of computational modeling in cardiac surgery. J Card Surg. 2014 May; 29(3):293-302. Lee LC, Genet M, Dang AB, Ge L, Guccione JM, Ratcliffe MB. PMID: 24708036; PMCID: PMC4045706.
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      91. Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis. PLoS One. 2013; 8(9):e73769. Huo Y, Luo T, Guccione JM, Teague SD, Tan W, Navia JA, Kassab GS. PMID: 24058488; PMCID: PMC3772875.
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      92. Biomechanical properties of human ascending thoracic aortic aneurysms. Ann Thorac Surg. 2013 Jul; 96(1):50-8. Azadani AN, Chitsaz S, Mannion A, Mookhoek A, Wisneski A, Guccione JM, Hope MD, Ge L, Tseng EE. PMID: 23731613.
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      130. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008 May; 135(5):1094-102, 1102.e1-2. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. PMID: 18455590; PMCID: PMC3773224.
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      131. Asymmetric mechanical properties of porcine aortic sinuses. Ann Thorac Surg. 2008 May; 85(5):1631-8. Gundiah N, Kam K, Matthews PB, Guccione J, Dwyer HA, Saloner D, Chuter TA, Guy TS, Ratcliffe MB, Tseng EE. PMID: 18442553.
        View in: PubMed   Mentions: 14     Fields:    Translation:Animals
      132. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):1017-24. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB. PMID: 17903523; PMCID: PMC2615826.
        View in: PubMed   Mentions: 14     Fields:    Translation:Animals
      133. Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2377-84. Jiang Y, Guccione JM, Ratcliffe MB, Hsu EW. PMID: 17604331.
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      134. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation. 2006 Dec 12; 114(24):2627-35. Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM. PMID: 17130342.
        View in: PubMed   Mentions: 109     Fields:    Translation:Animals
      135. The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):579-586.e3. Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB. PMID: 16515908; PMCID: PMC1482534.
        View in: PubMed   Mentions: 11     Fields:    Translation:Animals
      136. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. J Thorac Cardiovasc Surg. 2005 Oct; 130(4):1032-8. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB. PMID: 16214516; PMCID: PMC1475735.
        View in: PubMed   Mentions: 12     Fields:    Translation:Animals
      137. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H692-700. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. PMID: 15778283.
        View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
      138. Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):382-90. Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB. PMID: 15678050.
        View in: PubMed   Mentions: 30     Fields:    Translation:Animals
      139. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg. 2005 Jan; 79(1):185-93. Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. PMID: 15620941.
        View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
      140. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1844-50. Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. PMID: 15604126.
        View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
      141. Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study. Ann Thorac Surg. 2003 Oct; 76(4):1171-80; discussion 1180. Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB. PMID: 14530007.
        View in: PubMed   Mentions: 19     Fields:    Translation:Humans
      142. Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study. Circulation. 2002 Sep 24; 106(12 Suppl 1):I168-75. Moustakidis P, Maniar HS, Cupps BP, Absi T, Zheng J, Guccione JM, Sundt TM, Pasque MK. PMID: 12354728.
        View in: PubMed   Mentions: 16     Fields:    Translation:Animals
      143. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J. 2002 Sep-Oct; 48(5):508-13. Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB. PMID: 12296571.
        View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
      144. Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model study. J Thorac Cardiovasc Surg. 2001 Sep; 122(3):592-9. Guccione JM, Moonly SM, Wallace AW, Ratcliffe MB. PMID: 11547315.
        View in: PubMed   Mentions: 16     Fields:    Translation:Humans
      145. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. Ann Thorac Surg. 2001 Feb; 71(2):654-62. Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, Pasque MK. PMID: 11235723.
        View in: PubMed   Mentions: 51     Fields:    Translation:Animals
      146. Epicardial suction: a new approach to mechanical testing of the passive ventricular wall. J Biomech Eng. 2000 Oct; 122(5):479-87. Okamoto RJ, Moulton MJ, Peterson SJ, Li D, Pasque MK, Guccione JM. PMID: 11091948.
        View in: PubMed   Mentions: 10     Fields:    Translation:Animals
      147. The effects of cross-fiber deformation on axial fiber stress in myocardium. J Biomech Eng. 1999 Aug; 121(4):376-85. Zahalak GI, de Laborderie V, Guccione JM. PMID: 10464691.
        View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
      148. A distribution-moment model of deactivation in cardiac muscle. J Biomech. 1998 Nov; 31(11):1069-73. Guccione JM, Motabarzadeh I, Zahalak GI. PMID: 9880065.
        View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
      149. Measurements of active myocardial tension under a wide range of physiological loading conditions. J Biomech. 1997 Feb; 30(2):189-92. Guccione JM, Le Prell GS, de Tombe PP, Hunter WC. PMID: 9001940.
        View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
      150. Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection. Am J Physiol. 1997 Jan; 272(1 Pt 2):H469-77. Guccione JM, O'Dell WG, McCulloch AD, Hunter WC. PMID: 9038969.
        View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
      151. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: I--Cylindrical and spherical polar coordinates. J Biomech Eng. 1996 Nov; 118(4):452-63. Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD. PMID: 8950648.
        View in: PubMed   Mentions: 14     Fields:    Translation:Animals
      152. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates. J Biomech Eng. 1996 Nov; 118(4):464-72. Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD. PMID: 8950649.
        View in: PubMed   Mentions: 22     Fields:    Translation:Animals
      153. Finite element stress analysis of left ventricular mechanics in the beating dog heart. J Biomech. 1995 Oct; 28(10):1167-77. Guccione JM, Costa KD, McCulloch AD. PMID: 8550635.
        View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
      154. Mechanics of active contraction in cardiac muscle: Part II--Cylindrical models of the systolic left ventricle. J Biomech Eng. 1993 Feb; 115(1):82-90. Guccione JM, Waldman LK, McCulloch AD. PMID: 8445902.
        View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
      155. Mechanics of active contraction in cardiac muscle: Part I--Constitutive relations for fiber stress that describe deactivation. J Biomech Eng. 1993 Feb; 115(1):72-81. Guccione JM, McCulloch AD. PMID: 8445901.
        View in: PubMed   Mentions: 56     Fields:    Translation:Cells
      156. Large-scale finite element analysis of the beating heart. Crit Rev Biomed Eng. 1992; 20(5-6):427-49. McCulloch A, Waldman L, Rogers J, Guccione J. PMID: 1486784.
        View in: PubMed   Mentions: 24     Fields:    Translation:Animals
      157. Passive material properties of intact ventricular myocardium determined from a cylindrical model. J Biomech Eng. 1991 Feb; 113(1):42-55. Guccione JM, McCulloch AD, Waldman LK. PMID: 2020175.
        View in: PubMed   Mentions: 152     Fields:    Translation:Animals
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