Kenneth Ng, DDS

Title(s)Professor, Preventive & Restor Dent Sci
SchoolSchool of Dentistry
Address707 Parnassus Ave, #2254
San Francisco CA 94143
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    University of California, San FranciscoD.D.S.1995 Dentistry

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deep Mutational Scanning in Disease-related Genes with Saturation Mutagenesis-Reinforced Functional Assays (SMuRF). bioRxiv. 2023 Nov 27. Ma K, Ng KK, Huang S, Lake NJ, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Ho V, O'Connor CL, Joseph S, Brindley MA, Campbell KP, Lek M. PMID: 37873263; PMCID: PMC10592615.
      View in: PubMed   Mentions:
    2. Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma. bioRxiv. 2023 Jun 21. Tanaka M, Lum L, Hu K, Ledezma-Soto C, Samad B, Superville D, Ng K, Adams Z, Kersten K, Fong L, Combes AJ, Krummel M, Reeves M. PMID: 37162860; PMCID: PMC10168251.
      View in: PubMed   Mentions:
    3. Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun. 2022 Nov 09; 13(1):6768. Ozber N, Carr SC, Morris JS, Liang S, Watkins JL, Caldo KM, Hagel JM, Ng KKS, Facchini PJ. PMID: 36351903; PMCID: PMC9646721.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    4. Preparation and identification of carboxymethyl cellulose-degrading enzyme candidates for oilfield applications. J Biotechnol. 2022 Mar 10; 347:18-25. Scheffer G, Rachel NM, Ng KKS, Sen A, Gieg LM. PMID: 35131365.
      View in: PubMed   Mentions: 2     Fields:    
    5. Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis. J Biol Chem. 2021 10; 297(4):101211. Carr SC, Torres MA, Morris JS, Facchini PJ, Ng KKS. PMID: 34547292; PMCID: PMC8524200.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. The origin and radiation of the phosphoprotein phosphatase (PPP) enzymes of Eukaryotes. Sci Rep. 2021 07 01; 11(1):13681. Kerk D, Mattice JF, Valdés-Tresanco ME, Noskov SY, Ng KK, Moorhead GB. PMID: 34211082; PMCID: PMC8249667.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features. BBA Adv. 2021; 1:100005. Kerk D, Valdés-Tresanco ME, Toth R, Noskov SY, Ng KK, Moorhead GB. PMID: 37082010; PMCID: PMC10074919.
      View in: PubMed   Mentions: 2  
    8. Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity. Sci Rep. 2020 07 27; 10(1):12483. Marangoni JM, Wu SC, Fogen D, Wong SL, Ng KKS. PMID: 32719366; PMCID: PMC7385176.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J Biol Chem. 2019 10 04; 294(40):14482-14498. Lang DE, Morris JS, Rowley M, Torres MA, Maksimovich VA, Facchini PJ, Ng KKS. PMID: 31395658; PMCID: PMC6779432.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy. Plant J. 2018 07; 95(2):252-267. Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ. PMID: 29723437.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy. Plant J. 2018 May 19. Dastmalchi M, Chang L, Torres MA, Ng KKS, Facchini PJ. PMID: 29779229.
      View in: PubMed   Mentions: 6     Fields:    
    12. Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates. Sci Signal. 2018 04 03; 11(524). Labandera AM, Uhrig RG, Colville K, Moorhead GB, Ng KKS. PMID: 29615518.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. A conserved DGGK motif is essential for the function of the PglB oligosaccharyltransferase from Campylobacter jejuni. Glycobiology. 2017 10 01; 27(10):978-989. Barre Y, Nothaft H, Thomas C, Liu X, Li J, Ng KKS, Szymanski CM. PMID: 28922740.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    14. Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins. 2017 Aug; 85(8):1435-1445. Shaik MM, Bhattacharjee N, Feliks M, Ng KK, Field MJ. PMID: 28383118.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    15. Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. J Biol Chem. 2016 Nov 04; 291(45):23403-23415. Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK. PMID: 27573242; PMCID: PMC5095397.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Fungal cobalamin-independent methionine synthase: Insights from the model organism, Neurospora crassa. Arch Biochem Biophys. 2016 Jan 15; 590:125-137. Wheatley RW, Ng KKS, Kapoor M. PMID: 26657067.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Engineering Streptavidin and a Streptavidin-Binding Peptide with Infinite Binding Affinity and Reversible Binding Capability: Purification of a Tagged Recombinant Protein to High Purity via Affinity-Driven Thiol Coupling. PLoS One. 2015; 10(9):e0139137. Fogen D, Wu SC, Ng KK, Wong SL. PMID: 26406477; PMCID: PMC4583386.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    18. Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins. Org Biomol Chem. 2015 Jan 07; 13(1):283-98. Sanhueza CA, Cartmell J, El-Hawiet A, Szpacenko A, Kitova EN, Daneshfar R, Klassen JS, Lang DE, Eugenio L, Ng KK, Kitov PI, Bundle DR. PMID: 25367771.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    19. Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr D Biol Crystallogr. 2014 Dec 01; 70(Pt 12):3099-109. Zamyatkin D, Rao C, Hoffarth E, Jurca G, Rho H, Parra F, Grochulski P, Ng KK. PMID: 25478829.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order. J Virol. 2014 Sep; 88(18):10738-47. May J, Viswanathan P, Ng KK, Medvedev A, Korba B. PMID: 24991013; PMCID: PMC4178882.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile. J Biol Chem. 2014 Jan 24; 289(4):2331-43. Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. PMID: 24311789; PMCID: PMC3900976.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    22. The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits. Acta Crystallogr D Biol Crystallogr. 2013 May; 69(Pt 5):879-87. Barrette-Ng IH, Wu SC, Tjia WM, Wong SL, Ng KK. PMID: 23633599; PMCID: PMC3640474.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    23. Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan. J Biol Chem. 2012 Aug 10; 287(33):28132-43. Wheatley RW, Zheng RB, Richards MR, Lowary TL, Ng KK. PMID: 22707726; PMCID: PMC3431634.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    24. Development of a tetrameric streptavidin mutein with reversible biotin binding capability: engineering a mobile loop as an exit door for biotin. PLoS One. 2012; 7(4):e35203. O'Sullivan VJ, Barrette-Ng I, Hommema E, Hermanson GT, Schofield M, Wu SC, Honetschlaeger C, Ng KK, Wong SL. PMID: 22536357; PMCID: PMC3334968.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    25. Unexpected structure of a C. difficile toxin A ligand necessitates an annotation correction in a popular screening library. Chem Commun (Camb). 2011 Dec 07; 47(45):12397-9. Zhang P, Razi N, Eugenio L, Fentabil M, Kitova EN, Klassen JS, Bundle DR, Ng KK, Ling CC. PMID: 22016886.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Engineering monomeric streptavidin and its ligands with infinite affinity in binding but reversibility in interaction. Proteins. 2009 Nov 01; 77(2):404-12. Wu SC, Ng KK, Wong SL. PMID: 19425108.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    27. PII in higher plants: a modern role for an ancient protein. Trends Plant Sci. 2009 Sep; 14(9):505-11. Uhrig RG, Ng KK, Moorhead GB. PMID: 19720555.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    28. Structural insights into antibody recognition of mycobacterial polysaccharides. J Mol Biol. 2009 Sep 18; 392(2):381-92. Murase T, Zheng RB, Joe M, Bai Y, Marcus SL, Lowary TL, Ng KK. PMID: 19577573.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. A structural comparison of three isoforms of anionic trypsin from chum salmon (Oncorhynchus keta). Acta Crystallogr D Biol Crystallogr. 2009 Jul; 65(Pt 7):717-23. Toyota E, Iyaguchi D, Sekizaki H, Tateyama M, Ng KK. PMID: 19564692.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J Mol Biol. 2009 Jul 03; 390(1):10-6. Zamyatkin DF, Parra F, Machín A, Grochulski P, Ng KK. PMID: 19426741.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    31. Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile. Glycobiology. 2008 Sep; 18(9):698-706. Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, Lin S, Klassen JS, Palcic MM, Ng KK, Armstrong GD. PMID: 18509107.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    32. Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. J Biol Chem. 2008 Mar 21; 283(12):7705-12. Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK. PMID: 18184655.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    33. Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol. 2008; 320:137-56. Ng KK, Arnold JJ, Cameron CE. PMID: 18268843; PMCID: PMC2441838.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    34. Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana. J Biol Chem. 2007 Dec 07; 282(49):35733-40. Mizuno Y, Moorhead GB, Ng KK. PMID: 17913711.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    35. Crystal structure of Arabidopsis PII reveals novel structural elements unique to plants. Biochemistry. 2007 Feb 13; 46(6):1477-83. Mizuno Y, Berenger B, Moorhead GB, Ng KK. PMID: 17279613.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    36. Carbohydrate recognition by Clostridium difficile toxin A. Nat Struct Mol Biol. 2006 May; 13(5):460-1. Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK. PMID: 16622409.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    37. The PII signal transduction protein of Arabidopsis thaliana forms an arginine-regulated complex with plastid N-acetyl glutamate kinase. J Biol Chem. 2006 Mar 03; 281(9):5726-33. Chen YM, Ferrar TS, Lohmeier-Vogel EM, Lohmeir-Vogel E, Morrice N, Mizuno Y, Berenger B, Ng KK, Muench DG, Moorhead GB. PMID: 16377628.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    38. Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18373-8. Ho JG, Greco A, Rupnik M, Ng KK. PMID: 16344467; PMCID: PMC1317924.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    39. Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 09; 280(36):31999-2008. Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK. PMID: 16036920.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J Biol Chem. 2004 Apr 16; 279(16):16638-45. Ng KK, Pendás-Franco N, Rojo J, Boga JA, Machín A, Alonso JM, Parra F. PMID: 14764591.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    41. Engineering of a staphylokinase-based fibrinolytic agent with antithrombotic activity and targeting capability toward thrombin-rich fibrin and plasma clots. J Biol Chem. 2003 Jul 18; 278(29):26677-86. Lian Q, Szarka SJ, Ng KK, Wong SL. PMID: 12736246.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg. J Biol Chem. 2003 Jun 27; 278(26):24062-71. Barrette-Ng IH, Ng KK, Cherney MM, Pearce G, Ryan CA, James MN. PMID: 12684499.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    43. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14; 278(11):9489-95. Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. PMID: 12509436.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    44. Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem. 2002 Oct 18; 277(42):39960-6. Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN. PMID: 12163505.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
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