-
Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun. 2022 Nov 09; 13(1):6768.
Ozber N, Carr SC, Morris JS, Liang S, Watkins JL, Caldo KM, Hagel JM, Ng KKS, Facchini PJ. PMID: 36351903; PMCID: PMC9646721.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Preparation and identification of carboxymethyl cellulose-degrading enzyme candidates for oilfield applications. J Biotechnol. 2022 Mar 10; 347:18-25.
Scheffer G, Rachel NM, Ng KKS, Sen A, Gieg LM. PMID: 35131365.
View in:
PubMed Mentions:
2 Fields:
-
Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis. J Biol Chem. 2021 10; 297(4):101211.
Carr SC, Torres MA, Morris JS, Facchini PJ, Ng KKS. PMID: 34547292; PMCID: PMC8524200.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
The origin and radiation of the phosphoprotein phosphatase (PPP) enzymes of Eukaryotes. Sci Rep. 2021 07 01; 11(1):13681.
Kerk D, Mattice JF, Valdés-Tresanco ME, Noskov SY, Ng KK, Moorhead GB. PMID: 34211082; PMCID: PMC8249667.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features. BBA Adv. 2021; 1:100005.
Kerk D, Valdés-Tresanco ME, Toth R, Noskov SY, Ng KK, Moorhead GB. PMID: 37082010; PMCID: PMC10074919.
View in:
PubMed Mentions:
-
Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity. Sci Rep. 2020 07 27; 10(1):12483.
Marangoni JM, Wu SC, Fogen D, Wong SL, Ng KKS. PMID: 32719366; PMCID: PMC7385176.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J Biol Chem. 2019 10 04; 294(40):14482-14498.
Lang DE, Morris JS, Rowley M, Torres MA, Maksimovich VA, Facchini PJ, Ng KKS. PMID: 31395658; PMCID: PMC6779432.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy. Plant J. 2018 07; 95(2):252-267.
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ. PMID: 29723437.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy. Plant J. 2018 May 19.
Dastmalchi M, Chang L, Torres MA, Ng KKS, Facchini PJ. PMID: 29779229.
View in:
PubMed Mentions:
5 Fields:
-
Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates. Sci Signal. 2018 04 03; 11(524).
Labandera AM, Uhrig RG, Colville K, Moorhead GB, Ng KKS. PMID: 29615518.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
A conserved DGGK motif is essential for the function of the PglB oligosaccharyltransferase from Campylobacter jejuni. Glycobiology. 2017 10 01; 27(10):978-989.
Barre Y, Nothaft H, Thomas C, Liu X, Li J, Ng KKS, Szymanski CM. PMID: 28922740.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins. 2017 Aug; 85(8):1435-1445.
Shaik MM, Bhattacharjee N, Feliks M, Ng KK, Field MJ. PMID: 28383118.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. J Biol Chem. 2016 Nov 04; 291(45):23403-23415.
Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK. PMID: 27573242; PMCID: PMC5095397.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Fungal cobalamin-independent methionine synthase: Insights from the model organism, Neurospora crassa. Arch Biochem Biophys. 2016 Jan 15; 590:125-137.
Wheatley RW, Ng KKS, Kapoor M. PMID: 26657067.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Engineering Streptavidin and a Streptavidin-Binding Peptide with Infinite Binding Affinity and Reversible Binding Capability: Purification of a Tagged Recombinant Protein to High Purity via Affinity-Driven Thiol Coupling. PLoS One. 2015; 10(9):e0139137.
Fogen D, Wu SC, Ng KK, Wong SL. PMID: 26406477; PMCID: PMC4583386.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
-
Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins. Org Biomol Chem. 2015 Jan 07; 13(1):283-98.
Sanhueza CA, Cartmell J, El-Hawiet A, Szpacenko A, Kitova EN, Daneshfar R, Klassen JS, Lang DE, Eugenio L, Ng KK, Kitov PI, Bundle DR. PMID: 25367771.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr D Biol Crystallogr. 2014 Dec 01; 70(Pt 12):3099-109.
Zamyatkin D, Rao C, Hoffarth E, Jurca G, Rho H, Parra F, Grochulski P, Ng KK. PMID: 25478829.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order. J Virol. 2014 Sep; 88(18):10738-47.
May J, Viswanathan P, Ng KK, Medvedev A, Korba B. PMID: 24991013; PMCID: PMC4178882.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile. J Biol Chem. 2014 Jan 24; 289(4):2331-43.
Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. PMID: 24311789; PMCID: PMC3900976.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
-
The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits. Acta Crystallogr D Biol Crystallogr. 2013 May; 69(Pt 5):879-87.
Barrette-Ng IH, Wu SC, Tjia WM, Wong SL, Ng KK. PMID: 23633599; PMCID: PMC3640474.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
-
Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan. J Biol Chem. 2012 Aug 10; 287(33):28132-43.
Wheatley RW, Zheng RB, Richards MR, Lowary TL, Ng KK. PMID: 22707726; PMCID: PMC3431634.
View in:
PubMed Mentions:
25 Fields:
Translation:
Cells
-
Development of a tetrameric streptavidin mutein with reversible biotin binding capability: engineering a mobile loop as an exit door for biotin. PLoS One. 2012; 7(4):e35203.
O'Sullivan VJ, Barrette-Ng I, Hommema E, Hermanson GT, Schofield M, Wu SC, Honetschlaeger C, Ng KK, Wong SL. PMID: 22536357; PMCID: PMC3334968.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Unexpected structure of a C. difficile toxin A ligand necessitates an annotation correction in a popular screening library. Chem Commun (Camb). 2011 Dec 07; 47(45):12397-9.
Zhang P, Razi N, Eugenio L, Fentabil M, Kitova EN, Klassen JS, Bundle DR, Ng KK, Ling CC. PMID: 22016886.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Engineering monomeric streptavidin and its ligands with infinite affinity in binding but reversibility in interaction. Proteins. 2009 Nov 01; 77(2):404-12.
Wu SC, Ng KK, Wong SL. PMID: 19425108.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
PII in higher plants: a modern role for an ancient protein. Trends Plant Sci. 2009 Sep; 14(9):505-11.
Uhrig RG, Ng KK, Moorhead GB. PMID: 19720555.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
-
Structural insights into antibody recognition of mycobacterial polysaccharides. J Mol Biol. 2009 Sep 18; 392(2):381-92.
Murase T, Zheng RB, Joe M, Bai Y, Marcus SL, Lowary TL, Ng KK. PMID: 19577573.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
A structural comparison of three isoforms of anionic trypsin from chum salmon (Oncorhynchus keta). Acta Crystallogr D Biol Crystallogr. 2009 Jul; 65(Pt 7):717-23.
Toyota E, Iyaguchi D, Sekizaki H, Tateyama M, Ng KK. PMID: 19564692.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J Mol Biol. 2009 Jul 03; 390(1):10-6.
Zamyatkin DF, Parra F, Machín A, Grochulski P, Ng KK. PMID: 19426741.
View in:
PubMed Mentions:
30 Fields:
Translation:
Cells
-
Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile. Glycobiology. 2008 Sep; 18(9):698-706.
Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, Lin S, Klassen JS, Palcic MM, Ng KK, Armstrong GD. PMID: 18509107.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. J Biol Chem. 2008 Mar 21; 283(12):7705-12.
Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK. PMID: 18184655.
View in:
PubMed Mentions:
84 Fields:
Translation:
HumansCells
-
Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol. 2008; 320:137-56.
Ng KK, Arnold JJ, Cameron CE. PMID: 18268843; PMCID: PMC2441838.
View in:
PubMed Mentions:
109 Fields:
Translation:
AnimalsCells
-
Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana. J Biol Chem. 2007 Dec 07; 282(49):35733-40.
Mizuno Y, Moorhead GB, Ng KK. PMID: 17913711.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Crystal structure of Arabidopsis PII reveals novel structural elements unique to plants. Biochemistry. 2007 Feb 13; 46(6):1477-83.
Mizuno Y, Berenger B, Moorhead GB, Ng KK. PMID: 17279613.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Carbohydrate recognition by Clostridium difficile toxin A. Nat Struct Mol Biol. 2006 May; 13(5):460-1.
Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK. PMID: 16622409.
View in:
PubMed Mentions:
52 Fields:
Translation:
Cells
-
The PII signal transduction protein of Arabidopsis thaliana forms an arginine-regulated complex with plastid N-acetyl glutamate kinase. J Biol Chem. 2006 Mar 03; 281(9):5726-33.
Chen YM, Ferrar TS, Lohmeier-Vogel EM, Lohmeir-Vogel E, Morrice N, Mizuno Y, Berenger B, Ng KK, Muench DG, Moorhead GB. PMID: 16377628.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
-
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18373-8.
Ho JG, Greco A, Rupnik M, Ng KK. PMID: 16344467; PMCID: PMC1317924.
View in:
PubMed Mentions:
62 Fields:
Translation:
Cells
-
Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 09; 280(36):31999-2008.
Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK. PMID: 16036920.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J Biol Chem. 2004 Apr 16; 279(16):16638-45.
Ng KK, Pendás-Franco N, Rojo J, Boga JA, Machín A, Alonso JM, Parra F. PMID: 14764591.
View in:
PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
-
Engineering of a staphylokinase-based fibrinolytic agent with antithrombotic activity and targeting capability toward thrombin-rich fibrin and plasma clots. J Biol Chem. 2003 Jul 18; 278(29):26677-86.
Lian Q, Szarka SJ, Ng KK, Wong SL. PMID: 12736246.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg. J Biol Chem. 2003 Jun 27; 278(26):24062-71.
Barrette-Ng IH, Ng KK, Cherney MM, Pearce G, Ryan CA, James MN. PMID: 12684499.
View in:
PubMed Mentions:
10 Fields:
Translation:
Cells
-
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14; 278(11):9489-95.
Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. PMID: 12509436.
View in:
PubMed Mentions:
55 Fields:
Translation:
Cells
-
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem. 2002 Oct 18; 277(42):39960-6.
Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN. PMID: 12163505.
View in:
PubMed Mentions:
45 Fields:
Translation:
Cells