-
Deep Mutational Scanning in Disease-related Genes with Saturation Mutagenesis-Reinforced Functional Assays (SMuRF). bioRxiv. 2023 Nov 27.
Ma K, Ng KK, Huang S, Lake NJ, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Ho V, O'Connor CL, Joseph S, Brindley MA, Campbell KP, Lek M. PMID: 37873263; PMCID: PMC10592615.
View in:
PubMed Mentions:
-
Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma. bioRxiv. 2023 Jun 21.
Tanaka M, Lum L, Hu K, Ledezma-Soto C, Samad B, Superville D, Ng K, Adams Z, Kersten K, Fong L, Combes AJ, Krummel M, Reeves M. PMID: 37162860; PMCID: PMC10168251.
View in:
PubMed Mentions:
-
Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun. 2022 Nov 09; 13(1):6768.
Ozber N, Carr SC, Morris JS, Liang S, Watkins JL, Caldo KM, Hagel JM, Ng KKS, Facchini PJ. PMID: 36351903; PMCID: PMC9646721.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Preparation and identification of carboxymethyl cellulose-degrading enzyme candidates for oilfield applications. J Biotechnol. 2022 Mar 10; 347:18-25.
Scheffer G, Rachel NM, Ng KKS, Sen A, Gieg LM. PMID: 35131365.
View in:
PubMed Mentions:
2 Fields:
-
Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis. J Biol Chem. 2021 10; 297(4):101211.
Carr SC, Torres MA, Morris JS, Facchini PJ, Ng KKS. PMID: 34547292; PMCID: PMC8524200.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
The origin and radiation of the phosphoprotein phosphatase (PPP) enzymes of Eukaryotes. Sci Rep. 2021 07 01; 11(1):13681.
Kerk D, Mattice JF, Valdés-Tresanco ME, Noskov SY, Ng KK, Moorhead GB. PMID: 34211082; PMCID: PMC8249667.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features. BBA Adv. 2021; 1:100005.
Kerk D, Valdés-Tresanco ME, Toth R, Noskov SY, Ng KK, Moorhead GB. PMID: 37082010; PMCID: PMC10074919.
View in:
PubMed Mentions:
2
-
Engineering a disulfide-gated switch in streptavidin enables reversible binding without sacrificing binding affinity. Sci Rep. 2020 07 27; 10(1):12483.
Marangoni JM, Wu SC, Fogen D, Wong SL, Ng KKS. PMID: 32719366; PMCID: PMC7385176.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J Biol Chem. 2019 10 04; 294(40):14482-14498.
Lang DE, Morris JS, Rowley M, Torres MA, Maksimovich VA, Facchini PJ, Ng KKS. PMID: 31395658; PMCID: PMC6779432.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy. Plant J. 2018 07; 95(2):252-267.
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ. PMID: 29723437.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy. Plant J. 2018 May 19.
Dastmalchi M, Chang L, Torres MA, Ng KKS, Facchini PJ. PMID: 29779229.
View in:
PubMed Mentions:
6 Fields:
-
Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates. Sci Signal. 2018 04 03; 11(524).
Labandera AM, Uhrig RG, Colville K, Moorhead GB, Ng KKS. PMID: 29615518.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
A conserved DGGK motif is essential for the function of the PglB oligosaccharyltransferase from Campylobacter jejuni. Glycobiology. 2017 10 01; 27(10):978-989.
Barre Y, Nothaft H, Thomas C, Liu X, Li J, Ng KKS, Szymanski CM. PMID: 28922740.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins. 2017 Aug; 85(8):1435-1445.
Shaik MM, Bhattacharjee N, Feliks M, Ng KK, Field MJ. PMID: 28383118.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. J Biol Chem. 2016 Nov 04; 291(45):23403-23415.
Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK. PMID: 27573242; PMCID: PMC5095397.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Fungal cobalamin-independent methionine synthase: Insights from the model organism, Neurospora crassa. Arch Biochem Biophys. 2016 Jan 15; 590:125-137.
Wheatley RW, Ng KKS, Kapoor M. PMID: 26657067.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Engineering Streptavidin and a Streptavidin-Binding Peptide with Infinite Binding Affinity and Reversible Binding Capability: Purification of a Tagged Recombinant Protein to High Purity via Affinity-Driven Thiol Coupling. PLoS One. 2015; 10(9):e0139137.
Fogen D, Wu SC, Ng KK, Wong SL. PMID: 26406477; PMCID: PMC4583386.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins. Org Biomol Chem. 2015 Jan 07; 13(1):283-98.
Sanhueza CA, Cartmell J, El-Hawiet A, Szpacenko A, Kitova EN, Daneshfar R, Klassen JS, Lang DE, Eugenio L, Ng KK, Kitov PI, Bundle DR. PMID: 25367771.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallogr D Biol Crystallogr. 2014 Dec 01; 70(Pt 12):3099-109.
Zamyatkin D, Rao C, Hoffarth E, Jurca G, Rho H, Parra F, Grochulski P, Ng KK. PMID: 25478829.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
The p4-p2' amino acids surrounding human norovirus polyprotein cleavage sites define the core sequence regulating self-processing order. J Virol. 2014 Sep; 88(18):10738-47.
May J, Viswanathan P, Ng KK, Medvedev A, Korba B. PMID: 24991013; PMCID: PMC4178882.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile. J Biol Chem. 2014 Jan 24; 289(4):2331-43.
Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. PMID: 24311789; PMCID: PMC3900976.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
-
The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits. Acta Crystallogr D Biol Crystallogr. 2013 May; 69(Pt 5):879-87.
Barrette-Ng IH, Wu SC, Tjia WM, Wong SL, Ng KK. PMID: 23633599; PMCID: PMC3640474.
View in:
PubMed Mentions:
14 Fields:
Translation:
Cells
-
Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan. J Biol Chem. 2012 Aug 10; 287(33):28132-43.
Wheatley RW, Zheng RB, Richards MR, Lowary TL, Ng KK. PMID: 22707726; PMCID: PMC3431634.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
-
Development of a tetrameric streptavidin mutein with reversible biotin binding capability: engineering a mobile loop as an exit door for biotin. PLoS One. 2012; 7(4):e35203.
O'Sullivan VJ, Barrette-Ng I, Hommema E, Hermanson GT, Schofield M, Wu SC, Honetschlaeger C, Ng KK, Wong SL. PMID: 22536357; PMCID: PMC3334968.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Unexpected structure of a C. difficile toxin A ligand necessitates an annotation correction in a popular screening library. Chem Commun (Camb). 2011 Dec 07; 47(45):12397-9.
Zhang P, Razi N, Eugenio L, Fentabil M, Kitova EN, Klassen JS, Bundle DR, Ng KK, Ling CC. PMID: 22016886.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Engineering monomeric streptavidin and its ligands with infinite affinity in binding but reversibility in interaction. Proteins. 2009 Nov 01; 77(2):404-12.
Wu SC, Ng KK, Wong SL. PMID: 19425108.
View in:
PubMed Mentions:
5 Fields:
Translation:
Cells
-
PII in higher plants: a modern role for an ancient protein. Trends Plant Sci. 2009 Sep; 14(9):505-11.
Uhrig RG, Ng KK, Moorhead GB. PMID: 19720555.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
-
Structural insights into antibody recognition of mycobacterial polysaccharides. J Mol Biol. 2009 Sep 18; 392(2):381-92.
Murase T, Zheng RB, Joe M, Bai Y, Marcus SL, Lowary TL, Ng KK. PMID: 19577573.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
A structural comparison of three isoforms of anionic trypsin from chum salmon (Oncorhynchus keta). Acta Crystallogr D Biol Crystallogr. 2009 Jul; 65(Pt 7):717-23.
Toyota E, Iyaguchi D, Sekizaki H, Tateyama M, Ng KK. PMID: 19564692.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J Mol Biol. 2009 Jul 03; 390(1):10-6.
Zamyatkin DF, Parra F, Machín A, Grochulski P, Ng KK. PMID: 19426741.
View in:
PubMed Mentions:
31 Fields:
Translation:
Cells
-
Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile. Glycobiology. 2008 Sep; 18(9):698-706.
Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, Lin S, Klassen JS, Palcic MM, Ng KK, Armstrong GD. PMID: 18509107.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
-
Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. J Biol Chem. 2008 Mar 21; 283(12):7705-12.
Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK. PMID: 18184655.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansCells
-
Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol. 2008; 320:137-56.
Ng KK, Arnold JJ, Cameron CE. PMID: 18268843; PMCID: PMC2441838.
View in:
PubMed Mentions:
113 Fields:
Translation:
AnimalsCells
-
Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana. J Biol Chem. 2007 Dec 07; 282(49):35733-40.
Mizuno Y, Moorhead GB, Ng KK. PMID: 17913711.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Crystal structure of Arabidopsis PII reveals novel structural elements unique to plants. Biochemistry. 2007 Feb 13; 46(6):1477-83.
Mizuno Y, Berenger B, Moorhead GB, Ng KK. PMID: 17279613.
View in:
PubMed Mentions:
8 Fields:
Translation:
Cells
-
Carbohydrate recognition by Clostridium difficile toxin A. Nat Struct Mol Biol. 2006 May; 13(5):460-1.
Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK. PMID: 16622409.
View in:
PubMed Mentions:
54 Fields:
Translation:
Cells
-
The PII signal transduction protein of Arabidopsis thaliana forms an arginine-regulated complex with plastid N-acetyl glutamate kinase. J Biol Chem. 2006 Mar 03; 281(9):5726-33.
Chen YM, Ferrar TS, Lohmeier-Vogel EM, Lohmeir-Vogel E, Morrice N, Mizuno Y, Berenger B, Ng KK, Muench DG, Moorhead GB. PMID: 16377628.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18373-8.
Ho JG, Greco A, Rupnik M, Ng KK. PMID: 16344467; PMCID: PMC1317924.
View in:
PubMed Mentions:
63 Fields:
Translation:
Cells
-
Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 09; 280(36):31999-2008.
Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK. PMID: 16036920.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J Biol Chem. 2004 Apr 16; 279(16):16638-45.
Ng KK, Pendás-Franco N, Rojo J, Boga JA, Machín A, Alonso JM, Parra F. PMID: 14764591.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
Engineering of a staphylokinase-based fibrinolytic agent with antithrombotic activity and targeting capability toward thrombin-rich fibrin and plasma clots. J Biol Chem. 2003 Jul 18; 278(29):26677-86.
Lian Q, Szarka SJ, Ng KK, Wong SL. PMID: 12736246.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg. J Biol Chem. 2003 Jun 27; 278(26):24062-71.
Barrette-Ng IH, Ng KK, Cherney MM, Pearce G, Ryan CA, James MN. PMID: 12684499.
View in:
PubMed Mentions:
11 Fields:
Translation:
Cells
-
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14; 278(11):9489-95.
Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. PMID: 12509436.
View in:
PubMed Mentions:
56 Fields:
Translation:
Cells
-
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. J Biol Chem. 2002 Oct 18; 277(42):39960-6.
Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN. PMID: 12163505.
View in:
PubMed Mentions:
45 Fields:
Translation:
Cells