William DeGrado, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South, #452V
San Francisco CA 94158
Phone415-476-9679
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    Collapse Biography 
    Collapse Awards and Honors
    1988Du Vigneaud Award for Young Investigators in Peptide Research
    1989Protein Society Young Investigator Award
    1992Eli Lilly Award in Biological Chemistry
    1993DuPont Merck Summit Award
    1995Fellow, American Association for the Advancement of Science
    1998Fellow, AAAS
    1999Member, National Academy of Sciences (U.S.A.)
    2003Merrifield Award, Peptide Society
    2008Ralph F. Hirschmann Award in Peptide Chemistry (American Chemical Society)
    2009Makineni Award (APS)
    The Protein Society2015The Stein and Moore Award
    Weizmann Institute2016Max Perutz Memorial Lecture
    American Chemical Society2018Cope Scholar Award
    American Chemical Society2018M. Goodman Memorial Prize
    Franklin Institute & City Council of Philadelphia2020John C. Scott Award

    Collapse Overview 
    Collapse Overview
    One research interest is in the de novo design, in which one designs proteins or drugs beginning from first principles. This approach critically tests our understanding of protein folding and function, while also laying the groundwork for the design of molecules with properties unprecedented in nature.

    Collapse Research 
    Collapse Research Activities and Funding
    Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease
    NIH RF1AG061874Sep 30, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Deciphering the relationship between structure, dynamics and function in helical bundle proteins
    NIH R35GM122603May 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH UH3HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH UH2HL123423Sep 1, 2014 - Jul 14, 2016
    Role: Co-Principal Investigator
    Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER
    NIH R01AI097051Mar 1, 2012 - Feb 28, 2018
    Role: Co-Principal Investigator
    Development of drugs that target the M2 proton channel from the influenza A Virus
    NIH U01AI074571May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Design and mechanistic studies of mimics of antimicrobial peptides
    NIH R56AI074866Apr 15, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Design and mechanistic studies of mimics of antimicrobial peptides
    NIH R01AI074866Apr 15, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Proteomics to Biomimetic Polymers: Engineering Principle
    NIH R01EB002048Sep 24, 2002 - Aug 31, 2007
    Role: Principal Investigator
    Proteomics to Biomimetic Polymers: Engineering Principle
    NIH R01GM065803Sep 24, 2002 - Aug 31, 2006
    Role: Principal Investigator
    An Undulator Resource for Structural Biology
    NIH P41RR015301Jun 15, 2001 - Mar 31, 2013
    Role: Co-Investigator
    Bioorganic models for transmembrane proteins
    NIH R01GM060610Dec 1, 1999 - Apr 30, 2010
    Role: Principal Investigator
    Structure of M2 Proton Channel from Influenza A Virus
    NIH R01GM056423Aug 1, 1997 - Apr 30, 2017
    Role: Principal Investigator
    PURCHASE OF ANALYTICAL ULTRACENTRIFUGE
    NIH S10RR011854Mar 18, 1997 - Mar 17, 1998
    Role: Principal Investigator
    De Novo Design of Alpha-Helical Bundles
    NIH R01GM054616Aug 1, 1996 - Jun 30, 2018
    Role: Principal Investigator
    De novo design of alpha-helical bundles
    NIH R37GM054616Aug 1, 1996 - Jul 31, 2014
    Role: Principal Investigator
    Principles of Energy Transduction in Proteins
    NIH P01GM048130Aug 1, 1993 - Jul 31, 2010
    Role: Co-Investigator
    High Performance Computing for Biomedical Research
    NIH P41RR006009Sep 1, 1990 - Jul 31, 2013
    Role: Co-Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    ULTRAFAST OPTICAL PROCESSES LABORATORY
    NIH P41RR001348Aug 1, 1982 - May 31, 2012
    Role: Co-Investigator
    Degenerative and Dementing Diseases of Aging
    NIH P01AG002132Jan 1, 1981 - Mar 31, 2025
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De novo design of drug-binding proteins with predictable binding energy and specificity. Science. 2024 Apr 05; 384(6691):106-112. Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF. PMID: 38574125.
      View in: PubMed   Mentions:    Fields:    
    2. De novo-designed transmembrane proteins bind and regulate a cytokine receptor. Nat Chem Biol. 2024 Mar 13. Mravic M, He L, Kratochvil HT, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF. PMID: 38480980.
      View in: PubMed   Mentions:    Fields:    
    3. An enhanced broad-spectrum peptide inhibits Omicron variants in vivo. Cell Rep Med. 2024 Feb 20; 5(2):101418. Bi W, Tang K, Chen G, Xie Y, Polizzi NF, DeGrado WF, Yuan S, Dang B. PMID: 38340726; PMCID: PMC10897629.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Docking for Molecules That Bind in a Symmetric Stack with SymDOCK. J Chem Inf Model. 2024 Jan 22; 64(2):425-434. Smith MS, Knight IS, Kormos RC, Pepe JG, Kunach P, Diamond MI, Shahmoradian SH, Irwin JJ, DeGrado WF, Shoichet BK. PMID: 38191997; PMCID: PMC10806807.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. De novo design of drug-binding proteins with predictable binding energy and specificity. bioRxiv. 2023 Dec 23. Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF. PMID: 38187746; PMCID: PMC10769398.
      View in: PubMed   Mentions: 1  
    6. De novo Design of Peptides that Bind Specific Conformers of α-Synuclein. bioRxiv. 2023 Nov 16. Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF. PMID: 38014268; PMCID: PMC10680688.
      View in: PubMed   Mentions:
    7. Docking for molecules that bind in a symmetric stack with SymDOCK. bioRxiv. 2023 Oct 29. Smith MS, Knight IS, Kormos RC, Pepe JG, Kunach P, Diamond MI, Shahmoradian SH, Irwin JJ, DeGrado WF, Shoichet BK. PMID: 37961414; PMCID: PMC10634874.
      View in: PubMed   Mentions:
    8. Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface. Protein Sci. 2023 10; 32(10):e4755. Somberg NH, Medeiros-Silva J, Jo H, Wang J, DeGrado WF, Hong M. PMID: 37632140; PMCID: PMC10503410.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023 Aug 15. Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. PMID: 37425793; PMCID: PMC10326967.
      View in: PubMed   Mentions:
    10. Transient water wires mediate selective proton transport in designed channel proteins. Nat Chem. 2023 07; 15(7):1012-1021. Kratochvil HT, Watkins LC, Mravic M, Thomaston JL, Nicoludis JM, Somberg NH, Liu L, Hong M, Voth GA, DeGrado WF. PMID: 37308712; PMCID: PMC10475958.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nat Commun. 2023 05 26; 14(1):3048. Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR. PMID: 37236970; PMCID: PMC10220082.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    12. A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Nat Commun. 2023 04 12; 14(1):2052. Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH. PMID: 37045836; PMCID: PMC10090755.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. Proc Natl Acad Sci U S A. 2023 03 21; 120(12):e2300769120. Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. PMID: 36927157; PMCID: PMC10041141.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    14. Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology. bioRxiv. 2023 Feb 15. Mravic M, He L, Kratochvil H, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF. PMID: 36824741; PMCID: PMC9949092.
      View in: PubMed   Mentions:
    15. EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. bioRxiv. 2023 Feb 03. Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. PMID: 36778268; PMCID: PMC9915571.
      View in: PubMed   Mentions:
    16. Aβ and Tau Prions Causing Alzheimer's Disease. Methods Mol Biol. 2023; 2561:293-337. Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB. PMID: 36399277.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. Solution of the protein structure prediction problem at last: crucial innovations and next frontiers. Fac Rev. 2022; 11:38. Agard DA, Bowman GR, DeGrado W, Dokholyan NV, Zhou HX. PMID: 36644294; PMCID: PMC9815721.
      View in: PubMed   Mentions:
    18. SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers. Biochemistry. 2022 11 01; 61(21):2280-2294. Somberg NH, Wu WW, Medeiros-Silva J, Dregni AJ, Jo H, DeGrado WF, Hong M. PMID: 36219675; PMCID: PMC9583936.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    19. Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 2022 06; 29(6):537-548. Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL. PMID: 35655098.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    20. Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides. Chem Sci. 2022 Jun 07; 13(22):6599-6609. Zhang MY, Yang H, Ortiz G, Trnka MJ, Petronikolou N, Burlingame AL, DeGrado WF, Fujimori DG. PMID: 35756531; PMCID: PMC9172573.
      View in: PubMed   Mentions: 8  
    21. The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling. J Exp Med. 2022 05 02; 219(5). Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL. PMID: 35320345; PMCID: PMC8953085.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Brilacidin, a COVID-19 drug candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell. J Med Virol. 2022 05; 94(5):2188-2200. Hu Y, Jo H, DeGrado WF, Wang J. PMID: 35080027; PMCID: PMC8930451.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF. PMID: 35082148; PMCID: PMC8812518.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior. J Am Chem Soc. 2022 01 19; 144(2):769-776. Watkins LC, DeGrado WF, Voth GA. PMID: 34985907; PMCID: PMC8834648.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    25. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathol Commun. 2021 12 27; 9(1):201. Maxwell AM, Yuan P, Rivera BM, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C. PMID: 34961556; PMCID: PMC8711167.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Theoretical and experimental comparisons of simple peptide-membrane systems; towards defining the reaction space: general discussion. Faraday Discuss. 2021 12 24; 232(0):149-171. Aguilar MI, Al Nahas K, Barrera FN, Bassereau P, Bechinger B, Brand I, Chattopadhyay A, Clarke RJ, DeGrado WF, Deplazes E, Fletcher M, Fraternali F, Fuchs P, Garcia-Saez AJ, Gilbert R, Hoogenboom BW, Jarin Z, O'Shea P, Pabst G, Pal S, Sanderson JM, Seddon JM, Sengupta D, Siegel DP, Srivastava A, Tieleman DP, Tripathy M, Utterström J, Vácha R, Vanni S, Voth GA. PMID: 34908093.
      View in: PubMed   Mentions:    Fields:    
    27. Theoretical and experimental studies of complex peptide-membrane systems: general discussion. Faraday Discuss. 2021 12 24; 232(0):256-281. Aguilar M, Al Nahas K, Barrera F, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chattopadhyay A, Clarke RJ, DeGrado W, Deplazes E, Garcia Saez AJ, Hoogenboom B, Lund R, Milán Rodríguez P, O'Shea P, Pabst G, Pal S, Roux A, Sanderson J, Semeraro EF, Sengupta D, Siegel DP, van 't Hag L, Vijayakumar A, Zoranic L. PMID: 34909814.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    28. Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion. Faraday Discuss. 2021 12 24; 232(0):375-398. Aguilar M, Al Nahas K, Barrera F, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chattopadhyay A, DeGrado W, Fuchs P, Garcia Saez AJ, Hoogenboom B, Kapoor S, Milán Rodríguez P, Molloy J, O'Shea P, Pabst G, Pal S, Rice A, Roux A, Sanderson J, Seddon J, Tamm LK, Vijayakumar A. PMID: 34909817.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    29. Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides. Faraday Discuss. 2021 12 24; 232(0):9-48. Kratochvil HT, Newberry RW, Mensa B, Mravic M, DeGrado WF. PMID: 34693965; PMCID: PMC8979563.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    30. Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ. Elife. 2021 12 14; 10. Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF. PMID: 34904568; PMCID: PMC8719878.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    31. Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction. Blood Adv. 2021 12 14; 5(23):4901-4909. Fong KP, Molnar KS, Agard N, Litvinov RI, Kim OV, Wells JA, Weisel JW, DeGrado WF, Bennett JS. PMID: 34570183; PMCID: PMC9153048.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. De novo metalloprotein design. Nat Rev Chem. 2022 Jan; 6(1):31-50. Chalkley MJ, Mann SI, DeGrado WF. PMID: 35811759; PMCID: PMC9264687.
      View in: PubMed   Mentions: 18  
    33. Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry. 2021 Aug 03. Thomaston JL, Samways ML, Konstantinidi A, Ma C, Hu Y, Bruce Macdonald HE, Wang J, Essex JW, DeGrado WF, Kolocouris A. PMID: 34342217; PMCID: PMC8810914.
      View in: PubMed   Mentions: 4     Fields:    
    34. Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). Fong LK, Chalkley MJ, Tan SK, Grabe M, DeGrado WF. PMID: 34155106; PMCID: PMC8256006.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. J Clin Invest. 2021 06 15; 131(12). Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. PMID: 33956668; PMCID: PMC8203456.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    36. Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid. Biochemistry. 2021 06 01; 60(21):1722-1730. Fong KP, Ahmed IA, Mravic M, Jo H, Kim OV, Litvinov RI, Weisel JW, DeGrado WF, Gai F, Bennett JS. PMID: 34010565.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    37. Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy. J Am Chem Soc. 2021 05 26; 143(20):7839-7851. Dregni AJ, Wang HK, Wu H, Duan P, Jin J, DeGrado WF, Hong M. PMID: 33983722; PMCID: PMC8283780.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    38. Constructing ion channels from water-soluble α-helical barrels. Nat Chem. 2021 07; 13(7):643-650. Scott AJ, Niitsu A, Kratochvil HT, Lang EJM, Sengel JT, Dawson WM, Mahendran KR, Mravic M, Thomson AR, Brady RL, Liu L, Mulholland AJ, Bayley H, DeGrado WF, Wallace MI, Woolfson DN. PMID: 33972753; PMCID: PMC7611114.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    39. Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR. PMID: 33723045; PMCID: PMC8000134.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    40. Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site. J Am Chem Soc. 2021 03 10; 143(9):3330-3339. Naudin EA, McEwen AG, Tan SK, Poussin-Courmontagne P, Schmitt JL, Birck C, DeGrado WF, Torbeev V. PMID: 33635059; PMCID: PMC8012002.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    41. De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species. J Am Chem Soc. 2021 01 13; 143(1):252-259. Mann SI, Nayak A, Gassner GT, Therien MJ, DeGrado WF. PMID: 33373215; PMCID: PMC8006777.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    42. Allosteric cooperation in a de novo-designed two-domain protein. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33246-33253. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. PMID: 33318174; PMCID: PMC7776816.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    43. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. J Am Chem Soc. 2020 12 23; 142(51):21310-21321. Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB. PMID: 33301681; PMCID: PMC7790458.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    44. Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395; PMCID: PMC7700746.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. J Am Chem Soc. 2020 10 14; 142(41):17425-17433. Watkins LC, DeGrado WF, Voth GA. PMID: 32933245; PMCID: PMC7564090.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    46. Prion biology: implications for Alzheimer's disease therapeutics. Lancet Neurol. 2020 10; 19(10):802-803. Condello C, DeGrado WF, Prusiner SB. PMID: 32949533.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    47. A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 2020 09 04; 369(6508):1227-1233. Polizzi NF, DeGrado WF. PMID: 32883865; PMCID: PMC7526616.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    48. Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289; PMCID: PMC7442712.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    49. Deep mutational scanning reveals the structural basis for α-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544; PMCID: PMC7339969.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    50. De novo protein design, a retrospective. Q Rev Biophys. 2020 02 11; 53:e3. Korendovych IV, DeGrado WF. PMID: 32041676; PMCID: PMC7243446.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    51. X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry. 2020 02 04; 59(4):627-634. Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A. PMID: 31894969; PMCID: PMC7224692.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    52. De novo design of a homo-trimeric amantadine-binding protein. Elife. 2019 12 19; 8. Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. PMID: 31854299; PMCID: PMC6922598.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    53. A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. J Biol Chem. 2019 11 29; 294(48):18232-18243. Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. PMID: 31640988; PMCID: PMC6885615.
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    261. E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices. J Mol Biol. 2007 Feb 16; 366(2):436-48. Senes A, Chadi DC, Law PB, Walters RF, Nanda V, Degrado WF. PMID: 17174324.
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    262. Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding. Biochemistry. 2006 Sep 12; 45(36):10981-6. Bunagan MR, Cristian L, DeGrado WF, Gai F. PMID: 16953584.
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    263. Helix-packing motifs in membrane proteins. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13658-63. Walters RF, DeGrado WF. PMID: 16954199; PMCID: PMC1564267.
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    264. The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis. Angew Chem Int Ed Engl. 2006 Jul 24; 45(30):4951-4. Wade H, Stayrook SE, Degrado WF. PMID: 16819737.
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    265. Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction. Bioorg Med Chem Lett. 2006 Jul 01; 16(13):3380-2. Yin H, Gerlach LO, Miller MW, Moore DT, Liu D, Vilaire G, Bennett JS, DeGrado WF. PMID: 16678410.
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    266. Probing Membrane Insertion Activity of Antimicrobial Polymers via Coarse-grain Molecular Dynamics. J Chem Theory Comput. 2006 May; 2(3):649-655. Lopez CF, Nielsen SO, Srinivas G, Degrado WF, Klein ML. PMID: 18985168; PMCID: PMC2577386.
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    267. Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides. J Mol Biol. 2006 Jun 16; 359(4):930-9. North B, Cristian L, Fu Stowell X, Lear JD, Saven JG, Degrado WF. PMID: 16697010.
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    268. Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering. Biochemistry. 2006 Apr 18; 45(15):4957-64. Litvinov RI, Vilaire G, Li W, DeGrado WF, Weisel JW, Bennett JS. PMID: 16605263.
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    269. Polar networks control oligomeric assembly in membranes. J Am Chem Soc. 2006 Apr 05; 128(13):4170-1. Tatko CD, Nanda V, Lear JD, Degrado WF. PMID: 16568959.
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    270. Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study. J Phys Chem B. 2006 Mar 02; 110(8):3517-26. Pophristic V, Vemparala S, Ivanov I, Liu Z, Klein ML, DeGrado WF. PMID: 16494407.
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    271. Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics. J Am Chem Soc. 2006 Feb 15; 128(6):1778-9. Ivanov I, Vemparala S, Pophristic V, Kuroda K, DeGrado WF, McCammon JA, Klein ML. PMID: 16464062.
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    272. Computational design of heterochiral peptides against a helical target. J Am Chem Soc. 2006 Jan 25; 128(3):809-16. Nanda V, DeGrado WF. PMID: 16417370.
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    273. Arylamide derivatives as peptidomimetic inhibitors of calmodulin. Org Lett. 2006 Jan 19; 8(2):223-5. Yin H, Frederick KK, Liu D, Wand AJ, Degrado WF. PMID: 16408880.
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    274. Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography. J Am Chem Soc. 2005 Dec 14; 127(49):17266-76. Geremia S, Di Costanzo L, Randaccio L, Engel DE, Lombardi A, Nastri F, DeGrado WF. PMID: 16332076.
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    275. Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. J Am Chem Soc. 2005 Nov 23; 127(46):16098-106. Wei PP, Skulan AJ, Wade H, DeGrado WF, Solomon EI. PMID: 16287296.
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    276. Alpha-alpha linking motifs and interhelical orientations. Proteins. 2005 Nov 01; 61(2):325-37. Engel DE, DeGrado WF. PMID: 16104016.
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    277. The design and evaluation of heparin-binding foldamers. Angew Chem Int Ed Engl. 2005 Oct 21; 44(41):6685-9. Choi S, Clements DJ, Pophristic V, Ivanov I, Vemparala S, Bennett JS, Klein ML, Winkler JD, DeGrado WF. PMID: 16094685.
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    278. An atomic environment potential for use in protein structure prediction. J Mol Biol. 2005 Sep 30; 352(4):986-1001. Summa CM, Levitt M, Degrado WF. PMID: 16126228.
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    279. Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops. J Biol Inorg Chem. 2005 Aug; 10(5):539-49. Maglio O, Nastri F, Calhoun JR, Lahr S, Wade H, Pavone V, DeGrado WF, Lombardi A. PMID: 16091937.
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    280. T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. Biophys J. 2005 Dec; 89(6):4180-7. Wang T, Lau WL, DeGrado WF, Gai F. PMID: 16150962; PMCID: PMC1366983.
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    281. Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion. Biomaterials. 2005 Aug; 26(23):4757-66. Willcox PJ, Reinhart-King CA, Lahr SJ, DeGrado WF, Hammer DA. PMID: 15763255.
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    282. Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol. 2005 Jun 28; 5:11. Kovalenko OV, Metcalf DG, DeGrado WF, Hemler ME. PMID: 15985154; PMCID: PMC1190194.
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    283. Automated use of mutagenesis data in structure prediction. Proteins. 2005 May 15; 59(3):454-66. Nanda V, DeGrado WF. PMID: 15768404.
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    284. Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins. Proteins. 2005 May 15; 59(3):496-509. Adamian L, Nanda V, DeGrado WF, Liang J. PMID: 15789404.
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    285. X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils. J Mol Biol. 2005 May 06; 348(3):777-87. Slovic AM, Stayrook SE, North B, Degrado WF. PMID: 15826670.
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    286. De novo design of a redox-active minimal rubredoxin mimic. J Am Chem Soc. 2005 Apr 27; 127(16):5804-5. Nanda V, Rosenblatt MM, Osyczka A, Kono H, Getahun Z, Dutton PL, Saven JG, Degrado WF. PMID: 15839675.
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    287. Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability. J Mol Biol. 2005 May 20; 348(5):1225-33. Cristian L, Nanda V, Lear JD, DeGrado WF. PMID: 15854657.
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    288. Amphiphilic polymethacrylate derivatives as antimicrobial agents. J Am Chem Soc. 2005 Mar 30; 127(12):4128-9. Kuroda K, DeGrado WF. PMID: 15783168.
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    289. The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Sci. 2005 Apr; 14(4):856-61. Duong-Ly KC, Nanda V, Degrado WF, Howard KP. PMID: 15741338; PMCID: PMC2253456.
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    290. De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban. J Pept Res. 2005 Mar; 65(3):312-21. Slovic AM, Lear JD, DeGrado WF. PMID: 15787961.
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    291. Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Sci. 2005 Apr; 14(4):1019-24. Howard KP, Liu W, Crocker E, Nanda V, Lear J, Degrado WF, Smith SO. PMID: 15741331; PMCID: PMC2253437.
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    292. Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. J Am Chem Soc. 2005 Feb 09; 127(5):1346-7. Cochran FV, Wu SP, Wang W, Nanda V, Saven JG, Therien MJ, DeGrado WF. PMID: 15686346.
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    293. A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1424-9. Li W, Metcalf DG, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear JD, Degrado WF, Bennett JS. PMID: 15671157; PMCID: PMC547819.
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    294. Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol. 2005 Mar 18; 347(1):169-79. Stouffer AL, Nanda V, Lear JD, DeGrado WF. PMID: 15733926.
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    295. Analysis and design of turns in alpha-helical hairpins. J Mol Biol. 2005 Mar 11; 346(5):1441-54. Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF. PMID: 15713492.
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    296. Artificial diiron proteins: from structure to function. Biopolymers. 2005; 80(2-3):264-78. Calhoun JR, Nastri F, Maglio O, Pavone V, Lombardi A, DeGrado WF. PMID: 15700297.
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    297. Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. FEBS Lett. 2004 Dec 03; 578(1-2):140-4. Ghirlanda G, Hilcove SA, Pidikiti R, Johansson JS, Lear JD, Degrado WF, Eckenhoff RG. PMID: 15581631.
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    298. Simulated evolution of emergent chiral structures in polyalanine. J Am Chem Soc. 2004 Nov 10; 126(44):14459-67. Nanda V, Degrado WF. PMID: 15521766.
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    299. Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers. Chemistry. 2004 Oct 11; 10(20):5008-16. Doerksen RJ, Chen B, Liu D, Tew GN, Degrado WF, Klein ML. PMID: 15372664.
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    300. Length Dependent Helix-Coil Transition Kinetics of Nine Alanine-Based Peptides. J Phys Chem B. 2004 Sep 30; 108(39). Wang T, Zhu Y, Getahun Z, Du D, Huang CY, Degrado WF, Gai F. PMID: 24307864; PMCID: PMC3845522.
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    301. Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophys J. 2004 Nov; 87(5):3421-9. Lear JD, Stouffer AL, Gratkowski H, Nanda V, Degrado WF. PMID: 15315956; PMCID: PMC1304808.
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    302. De novo design of catalytic proteins. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11566-70. Kaplan J, DeGrado WF. PMID: 15292507; PMCID: PMC511021.
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    303. Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 Aug; 14(4):465-79. Senes A, Engel DE, DeGrado WF. PMID: 15313242.
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    304. De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1. J Am Chem Soc. 2004 Jul 07; 126(26):8141-7. Ghirlanda G, Osyczka A, Liu W, Antolovich M, Smith KM, Dutton PL, Wand AJ, DeGrado WF. PMID: 15225055.
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    305. Structural basis for integrin alphaIIbbeta3 clustering. Biochem Soc Trans. 2004 Jun; 32(Pt3):412-5. Li R, Bennett JS, Degrado WF. PMID: 15157149.
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    306. A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. J Am Chem Soc. 2004 Apr 28; 126(16):5078-9. Tucker MJ, Getahun Z, Nanda V, DeGrado WF, Gai F. PMID: 15099085.
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    307. Amino acid propensities are position-dependent throughout the length of alpha-helices. J Mol Biol. 2004 Apr 09; 337(5):1195-205. Engel DE, DeGrado WF. PMID: 15046987.
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    308. Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem. 2004 Jun 18; 279(25):26666-73. Li R, Gorelik R, Nanda V, Law PB, Lear JD, DeGrado WF, Bennett JS. PMID: 15067009.
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    309. Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl. 2004 Feb 20; 43(9):1158-62. Liu D, Choi S, Chen B, Doerksen RJ, Clements DJ, Winkler JD, Klein ML, DeGrado WF. PMID: 14983462.
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    310. Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1828-33. Slovic AM, Kono H, Lear JD, Saven JG, DeGrado WF. PMID: 14766985; PMCID: PMC357012.
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    311. Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophys J. 2004 Jan; 86(1 Pt 1):272-84. Lau WL, Ege DS, Lear JD, Hammer DA, DeGrado WF. PMID: 14695269; PMCID: PMC1303790.
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    312. Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol. 2003 Dec 12; 334(5):1101-15. Calhoun JR, Kono H, Lahr S, Wang W, DeGrado WF, Saven JG. PMID: 14643669.
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    313. Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15486-91. Zhu Y, Alonso DO, Maki K, Huang CY, Lahr SJ, Daggett V, Roder H, DeGrado WF, Gai F. PMID: 14671331; PMCID: PMC307594.
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    314. Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14772-7. Cristian L, Lear JD, DeGrado WF. PMID: 14657351; PMCID: PMC299801.
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    315. De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. J Mol Biol. 2003 Nov 14; 334(1):1-12. Signarvic RS, DeGrado WF. PMID: 14596795.
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    316. Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange. Protein Sci. 2003 Aug; 12(8):1732-40. Cristian L, Lear JD, DeGrado WF. PMID: 12876322; PMCID: PMC2323959.
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    317. Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry. 2003 Jun 03; 42(21):6400-7. Lear JD, Gratkowski H, Adamian L, Liang J, DeGrado WF. PMID: 12767221.
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    318. Computational biology: Biosensor design. Nature. 2003 May 08; 423(6936):132-3. DeGrado WF. PMID: 12736670.
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    319. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science. 2003 May 02; 300(5620):795-8. Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, Weisel JW, Lear JD, DeGrado WF, Bennett JS. PMID: 12730600.
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    320. How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci. 2003 Apr; 12(4):647-65. DeGrado WF, Gratkowski H, Lear JD. PMID: 12649422; PMCID: PMC2323850.
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    321. Preorganization of molecular binding sites in designed diiron proteins. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):3772-7. Maglio O, Nastri F, Pavone V, Lombardi A, DeGrado WF. PMID: 12655072; PMCID: PMC152997.
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    322. The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci. 2003 Mar; 12(3):520-31. Walsh ST, Cheng RP, Wright WW, Alonso DO, Daggett V, Vanderkooi JM, DeGrado WF. PMID: 12592022; PMCID: PMC2312439.
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    323. Computational design of a water-soluble analog of phospholamban. Protein Sci. 2003 Feb; 12(2):337-48. Slovic AM, Summa CM, Lear JD, DeGrado WF. PMID: 12538897; PMCID: PMC2312418.
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    324. Sliding helix and change of coordination geometry in a model di-MnII protein. Angew Chem Int Ed Engl. 2003 Jan 27; 42(4):417-20. DeGrado WF, Di Costanzo L, Geremia S, Lombardi A, Pavone V, Randaccio L. PMID: 12569505.
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    325. Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor. J Am Chem Soc. 2003 Jan 15; 125(2):560-9. Papoian GA, DeGrado WF, Klein ML. PMID: 12517172.
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    326. Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc. 2003 Jan 15; 125(2):405-11. Getahun Z, Huang CY, Wang T, De León B, DeGrado WF, Gai F. PMID: 12517152.
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    327. Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng. 2003 Jan; 16(1):65-72. Li R, Hoess RH, Bennett JS, DeGrado WF. PMID: 12646694.
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    328. Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry. 2002 Dec 31; 41(52):15618-24. Li R, Babu CR, Valentine K, Lear JD, Wand AJ, Bennett JS, DeGrado WF. PMID: 12501190.
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    329. Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8568-72. Howard KP, Lear JD, DeGrado WF. PMID: 12084917; PMCID: PMC124313.
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    330. Noncovalent self-assembly of a heterotetrameric diiron protein. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5150-4. Marsh EN, DeGrado WF. PMID: 11959963; PMCID: PMC122737.
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    331. Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2788-93. Huang CY, Getahun Z, Zhu Y, Klemke JW, DeGrado WF, Gai F. PMID: 11867741; PMCID: PMC122426.
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    332. Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. J Am Chem Soc. 2001 Dec 26; 123(51):12749-57. Di Costanzo L, Wade H, Geremia S, Randaccio L, Pavone V, DeGrado WF, Lombardi A. PMID: 11749531.
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    333. Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn. J Am Chem Soc. 2001 Dec 19; 123(50):12710-1. Cheng RP, Suich DJ, Cheng H, Roder H, DeGrado WF. PMID: 11741449.
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    334. Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides. J Am Chem Soc. 2001 Dec 05; 123(48):12111-2. Huang CY, Getahun Z, Wang T, DeGrado WF, Gai F. PMID: 11724630.
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    335. Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12462-7. Li R, Babu CR, Lear JD, Wand AJ, Bennett JS, DeGrado WF. PMID: 11606749; PMCID: PMC60076.
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    336. Introduction: protein design. Chem Rev. 2001 Oct 10; 101(10):3025-6. DeGrado WF. PMID: 11749399.
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    337. beta-Peptides: from structure to function. Chem Rev. 2001 Oct; 101(10):3219-32. Cheng RP, Gellman SH, DeGrado WF. PMID: 11710070.
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    338. Temperature-dependent helix-coil transition of an alanine based peptide. J Am Chem Soc. 2001 Sep 26; 123(38):9235-8. Huang CY, Klemke JW, Getahun Z, DeGrado WF, Gai F. PMID: 11562202.
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    339. De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions. J Am Chem Soc. 2001 May 30; 123(21):5162-3. Cheng RP, DeGrado WF. PMID: 11457373.
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    340. Proton and metal ion-dependent assembly of a model diiron protein. Protein Sci. 2001 May; 10(5):958-69. Pasternak A, Kaplan J, Lear JD, Degrado WF. PMID: 11316876; PMCID: PMC2374189.
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    341. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hathaway for performing matrix-assisted laser desorption/ionization analyses. Angew Chem Int Ed Engl. 2001 Apr 17; 40(8):1494-1496. Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. PMID: 11317312.
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    342. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability. Angew Chem Int Ed Engl. 2001 Apr 17; 40(8):1494-1496. Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. PMID: 29712367.
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    343. Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. Biochemistry. 2001 Mar 06; 40(9):2790-6. Tang Y, Ghirlanda G, Vaidehi N, Kua J, Mainz DT, Goddard III WA, DeGrado WF, Tirrell DA. PMID: 11258889.
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    344. Design of three-dimensional domain-swapped dimers and fibrous oligomers. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1404-9. Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D. PMID: 11171963; PMCID: PMC29269.
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    345. Polar side chains drive the association of model transmembrane peptides. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):880-5. Gratkowski H, Lear JD, DeGrado WF. PMID: 11158564; PMCID: PMC14678.
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    346. Hydrophobic core malleability of a de novo designed three-helix bundle protein. J Mol Biol. 2001 Jan 12; 305(2):361-73. Walsh ST, Sukharev VI, Betz SF, Vekshin NL, DeGrado WF. PMID: 11124911.
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    347. Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13021-6. Talaga DS, Lau WL, Roder H, Tang J, Jia Y, DeGrado WF, Hochstrasser RM. PMID: 11087856; PMCID: PMC27171.
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    348. pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry. 2000 Nov 21; 39(46):14160-70. Salom D, Hill BR, Lear JD, DeGrado WF. PMID: 11087364; PMCID: PMC3060174.
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    349. Structural consequences of an amino acid deletion in the B1 domain of protein G. Proteins. 2000 Nov 15; 41(3):323-33. O'Neil KT, Bach AC, DeGrado WF. PMID: 11025544.
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    350. De novo design of helical bundles as models for understanding protein folding and function. Acc Chem Res. 2000 Nov; 33(11):745-54. Hill RB, Raleigh DP, Lombardi A, DeGrado WF. PMID: 11087311; PMCID: PMC3050006.
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    351. Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity. Bioorg Med Chem. 2000 Sep; 8(9):2229-41. Suich DJ, Mousa SA, Singh G, Liapakis G, Reisine T, DeGrado WF. PMID: 11026536.
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    352. The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin. J Biol Chem. 2000 Jun 16; 275(24):18337-43. Helluin O, Chan C, Vilaire G, Mousa S, DeGrado WF, Bennett JS. PMID: 10751402.
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    353. Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6298-305. Lombardi A, Summa CM, Geremia S, Randaccio L, Pavone V, DeGrado WF. PMID: 10841536; PMCID: PMC18597.
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    354. A polar, solvent-exposed residue can be essential for native protein structure. Structure. 2000 May 15; 8(5):471-9. Hill RB, DeGrado WF. PMID: 10801493; PMCID: PMC3050062.
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    355. Asparagine-mediated self-association of a model transmembrane helix. Nat Struct Biol. 2000 Feb; 7(2):161-6. Choma C, Gratkowski H, Lear JD, DeGrado WF. PMID: 10655620.
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    356. Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry. 1999 Sep 14; 38(37):11905-13. Kochendoerfer GG, Salom D, Lear JD, Wilk-Orescan R, Kent SB, DeGrado WF. PMID: 10508393.
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    357. The twists and turns of beta-peptides. J Pept Res. 1999 Sep; 54(3):206-17. DeGrado WF, Schneider JP, Hamuro Y. PMID: 10517158.
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    358. Tertiary templates for the design of diiron proteins. Curr Opin Struct Biol. 1999 Aug; 9(4):500-8. Summa CM, Lombardi A, Lewis M, DeGrado WF. PMID: 10449377.
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    359. Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Sci. 1999 Jul; 8(7):1410-22. Patterson WR, Anderson DH, DeGrado WF, Cascio D, Eisenberg D. PMID: 10422829; PMCID: PMC2144380.
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    360. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5486-91. Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF. PMID: 10318910; PMCID: PMC21886.
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    361. Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds. Bioorg Med Chem Lett. 1999 Apr 05; 9(7):937-42. Rockwell AL, Rafalski M, Pitts WJ, Batt DG, Petraitis JJ, DeGrado WF, Mousa S, Jadhav PK. PMID: 10230615.
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    362. The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2036-41. Hamm P, Lim M, DeGrado WF, Hochstrasser RM. PMID: 10051590; PMCID: PMC26732.
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    363. Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein. J Biol Chem. 1999 Feb 26; 274(9):5474-82. Gandhi CS, Shuck K, Lear JD, Dieckmann GR, DeGrado WF, Lamb RA, Pinto LH. PMID: 10026160.
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    364. Exploration of the structural features defining the conduction properties of a synthetic ion channel. Biophys J. 1999 Feb; 76(2):618-30. Dieckmann GR, Lear JD, Zhong Q, Klein ML, DeGrado WF, Sharp KA. PMID: 9929468; PMCID: PMC1300068.
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    365. De novo design and structural characterization of proteins and metalloproteins. Annu Rev Biochem. 1999; 68:779-819. DeGrado WF, Summa CM, Pavone V, Nastri F, Lombardi A. PMID: 10872466.
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    366. Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists. Bioorg Med Chem Lett. 1998 Dec 15; 8(24):3499-504. Xue CB, Roderick J, Mousa S, Olson RE, DeGrado WF. PMID: 9934460.
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    367. From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin. J Mol Biol. 1998 Aug 14; 281(2):379-91. Ghirlanda G, Lear JD, Lombardi A, DeGrado WF. PMID: 9698554.
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    368. The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. J Mol Biol. 1998 Jul 31; 280(5):897-912. Dieckmann GR, McRorie DK, Lear JD, Sharp KA, DeGrado WF, Pecoraro VL. PMID: 9671558.
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    369. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci. 1998 Jun; 7(6):1404-14. Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. PMID: 9655345; PMCID: PMC2144029.
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    370. Macrocyclic amino carboxylates as selective MMP-8 inhibitors. J Med Chem. 1998 May 21; 41(11):1749-51. Cherney RJ, Wang L, Meyer DT, Xue CB, Wasserman ZR, Hardman KD, Welch PK, Covington MB, Copeland RA, Arner EC, DeGrado WF, Decicco CP. PMID: 9599226.
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    371. Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production. J Med Chem. 1998 May 21; 41(11):1745-8. Xue CB, He X, Roderick J, DeGrado WF, Cherney RJ, Hardman KD, Nelson DJ, Copeland RA, Jaffee BD, Decicco CP. PMID: 9599225.
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    372. Analysis and design of three-stranded coiled coils and three-helix bundles. Fold Des. 1998; 3(2):R29-40. Schneider JP, Lombardi A, DeGrado WF. PMID: 9565750.
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    373. Two models of the influenza A M2 channel domain: verification by comparison. Fold Des. 1998; 3(6):443-8. Forrest LR, DeGrado WF, Dieckmann GR, Sansom MS. PMID: 9889158.
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    374. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11301-6. Pinto LH, Dieckmann GR, Gandhi CS, Papworth CG, Braman J, Shaughnessy MA, Lear JD, Lamb RA, DeGrado WF. PMID: 9326604; PMCID: PMC23448.
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    375. Proteins from scratch. Science. 1997 Oct 03; 278(5335):80-1. DeGrado WF. PMID: 9340760.
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    376. Modeling transmembrane helical oligomers. Curr Opin Struct Biol. 1997 Aug; 7(4):486-94. Dieckmann GR, DeGrado WF. PMID: 9266169.
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    377. Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid. Bioorg Med Chem. 1997 Apr; 5(4):693-705. Xue CB, Roderick J, Jackson S, Rafalski M, Rockwell A, Mousa S, Olson RE, DeGrado WF. PMID: 9158868.
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    378. Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. J Biol Chem. 1997 Mar 28; 272(13):8137-40. Bennett JS, Chan C, Vilaire G, Mousa SA, DeGrado WF. PMID: 9079626.
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    379. De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles. Biochemistry. 1997 Mar 04; 36(9):2450-8. Betz SF, Liebman PA, DeGrado WF. PMID: 9054549.
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    380. The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies. Protein Sci. 1997 Jan; 6(1):80-8. Ogihara NL, Weiss MS, Degrado WF, Eisenberg D. PMID: 9007979; PMCID: PMC2143514.
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    381. Thermodynamic analysis of a designed three-stranded coiled coil. Biochemistry. 1996 Nov 19; 35(46):14480-5. Boice JA, Dieckmann GR, DeGrado WF, Fairman R. PMID: 8931544.
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    382. Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity. Coron Artery Dis. 1996 Oct; 7(10):767-74. Mousa SA, Forsythe M, Lorelli W, Bozarth J, Xue CB, Wityak J, Sielecki TM, Olson RE, DeGrado W, Kapil R, Hussain M, Wexler R, Thoolen MJ, Reilly TM. PMID: 8970768.
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    383. Expression of de novo designed alpha-helical bundles. Acta Chem Scand (Cph). 1996 Aug; 50(8):688-96. Betz SF, Bryson JW, Passador MC, Brown RJ, O'Neil KT, DeGrado WF. PMID: 8756357.
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    384. Protein minimization: downsizing through mutation. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5680-1. DeGrado WF, Sosnick TR. PMID: 8650151; PMCID: PMC39119.
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    385. Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils. Biochemistry. 1996 May 28; 35(21):6955-62. Betz SF, DeGrado WF. PMID: 8639647.
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    386. In vitro evolution of thermodynamically stable turns. Nat Struct Biol. 1996 May; 3(5):446-51. Zhou HX, Hoess RH, DeGrado WF. PMID: 8612075.
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    387. The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins. 1996 Apr; 24(4):427-32. Sosnick TR, Jackson S, Wilk RR, Englander SW, DeGrado WF. PMID: 9162943.
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    388. Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist. Circulation. 1996 Feb 01; 93(3):537-43. Mousa SA, DeGrado WF, Mu DX, Kapil RP, Lucchesi BR, Reilly TM. PMID: 8565173.
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    389. De novo design of heterotrimeric coiled coils. Biopolymers. 1996; 40(5):495-504. Lombardi A, Bryson JW, DeGrado WF. PMID: 9062072.
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    390. Crystallization of a designed peptide from a molten globule ensemble. Fold Des. 1996; 1(1):57-64. Betz SF, Raleigh DP, DeGrado WF, Lovejoy B, Anderson D, Ogihara N, Eisenberg D. PMID: 9079364.
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    391. Protein design: a hierarchic approach. Science. 1995 Nov 10; 270(5238):935-41. Bryson JW, Betz SF, Lu HS, Suich DJ, Zhou HX, O'Neil KT, DeGrado WF. PMID: 7481798.
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    392. Native-like and structurally characterized designed alpha-helical bundles. Curr Opin Struct Biol. 1995 Aug; 5(4):457-63. Betz SF, Bryson JW, DeGrado WF. PMID: 8528761.
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    393. Design of two-stranded and three-stranded coiled-coil peptides. Philos Trans R Soc Lond B Biol Sci. 1995 Apr 29; 348(1323):81-8. Betz S, Fairman R, O'Neil K, Lear J, Degrado W. PMID: 7770490.
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    394. Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G. Proteins. 1995 Jan; 21(1):11-21. O'Neil KT, Hoess RH, Raleigh DP, DeGrado WF. PMID: 7716165.
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    395. Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein. Protein Sci. 1994 Dec; 3(12):2419-27. Regan L, Rockwell A, Wasserman Z, DeGrado W. PMID: 7756995; PMCID: PMC2142780.
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    396. Design and synthesis of simplified energy-converting proteins. Biochem Soc Trans. 1994 Aug; 22(3):689-93. Farid RS, Robertson DE, Moser CC, Pilloud D, DeGrado WF, Dutton PL. PMID: 7821665.
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    397. A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4859-63. Kienker PK, DeGrado WF, Lear JD. PMID: 7515180; PMCID: PMC43888.
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    398. Design and synthesis of multi-haem proteins. Nature. 1994 Mar 31; 368(6470):425-32. Robertson DE, Farid RS, Moser CC, Urbauer JL, Mulholland SE, Pidikiti R, Lear JD, Wand AJ, DeGrado WF, Dutton PL. PMID: 8133888.
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    399. Identification of recognition sequences of adhesion molecules using phage display technology. Methods Enzymol. 1994; 245:370-86. O'Neil KT, DeGrado WF, Mousa SA, Ramachandran N, Hoess RH. PMID: 7539093.
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    400. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10429-33. Fairman R, Beran-Steed RK, Anthony-Cahill SJ, Lear JD, Stafford WF, DeGrado WF, Benfield PA, Brenner SL. PMID: 8248126; PMCID: PMC47790.
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    401. Peptide engineering. Catalytic molten globules. Nature. 1993 Oct 07; 365(6446):488-9. DeGrado WF. PMID: 8413599.
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    402. Metal ion-dependent modulation of the dynamics of a designed protein. Science. 1993 Aug 13; 261(5123):879-85. Handel TM, Williams SA, DeGrado WF. PMID: 8346440.
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    403. Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science. 1993 Feb 26; 259(5099):1288-93. Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D. PMID: 8446897.
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    404. Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library. Proteins. 1992 Dec; 14(4):509-15. O'Neil KT, Hoess RH, Jackson SA, Ramachandran NS, Mousa SA, DeGrado WF. PMID: 1438188.
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    405. Calmodulin binding to alpha 1-purothionin: solution binding and modeling of the complex. Proteins. 1992 Oct; 14(2):127-38. Rao U, Teeter MM, Erickson-Viitanen S, DeGrado WF. PMID: 1409564.
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    406. Crystallization of proton channel peptides. Protein Sci. 1992 Aug; 1(8):1073-7. Lovejoy B, Akerfeldt KS, DeGrado WF, Eisenberg D. PMID: 1284681; PMCID: PMC2142170.
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    407. Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles. Biochemistry. 1992 Jul 21; 31(28):6608-16. Chung LA, Lear JD, DeGrado WF. PMID: 1378757.
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    408. X-ray grade crystals of a designed alpha-helical coiled coil. Protein Sci. 1992 Jul; 1(7):956-7. Lovejoy B, Le TC, Lüthy R, Cascio D, O'Neil KT, DeGrado WF, Eisenberg D. PMID: 1304378; PMCID: PMC2142157.
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    409. Peptide models for the membrane destabilizing actions of viral fusion proteins. Biopolymers. 1992 Apr; 32(4):309-14. Epand RM, Cheetham JJ, Epand RF, Yeagle PL, Richardson CD, Rockwell A, Degrado WF. PMID: 1623124.
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    410. Molecular characterization of helix-loop-helix peptides. Science. 1992 Feb 21; 255(5047):979-83. Anthony-Cahill SJ, Benfield PA, Fairman R, Wasserman ZR, Brenner SL, Stafford WF, Altenbach C, Hubbell WL, DeGrado WF. PMID: 1312255.
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    411. Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesicles. Biochemistry. 1991 Oct 22; 30(42):10211-20. Rafalski M, Ortiz A, Rockwell A, van Ginkel LC, Lear JD, DeGrado WF, Wilschut J. PMID: 1931950.
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    412. DNA-induced increase in the alpha-helical content of C/EBP and GCN4. Biochemistry. 1991 Sep 17; 30(37):9030-4. O'Neil KT, Shuman JD, Ampe C, DeGrado WF. PMID: 1892816.
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    413. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science. 1990 Nov 02; 250(4981):646-51. O'Neil KT, DeGrado WF. PMID: 2237415.
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    414. Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41. Biochemistry. 1990 Aug 28; 29(34):7917-22. Rafalski M, Lear JD, DeGrado WF. PMID: 2261447.
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    415. Design of DNA-binding peptides based on the leucine zipper motif. Science. 1990 Aug 17; 249(4970):774-8. O'Neil KT, Hoess RH, DeGrado WF. PMID: 2389143.
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    416. Crystal structure of alpha 1: implications for protein design. Science. 1990 Aug 03; 249(4968):543-6. Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D. PMID: 2382133.
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    417. How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices. Trends Biochem Sci. 1990 Feb; 15(2):59-64. O'Neil KT, DeGrado WF. PMID: 2186516.
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    419. Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine. J Biol Chem. 1989 Aug 25; 264(24):14571-8. O'Neil KT, Erickson-Viitanen S, DeGrado WF. PMID: 2760074.
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    422. Contributions of chemistry: biotechnology and materials science. Science. 1989 Jan 06; 243(4887):102-3. Degrado WF. PMID: 17780427.
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    427. Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity. Science. 1987 Jun 12; 236(4807):1454-6. O'Neil KT, Wolfe HR, Erickson-Viitanen S, DeGrado WF. PMID: 3589665.
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    428. Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2. J Biol Chem. 1987 May 15; 262(14):6500-5. Lear JD, DeGrado WF. PMID: 3571268.
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    429. Predicted calmodulin-binding sequence in the gamma subunit of phosphorylase b kinase. Proteins. 1987; 2(1):20-33. DeGrado WF, Erickson-Viitanen S, Wolfe HR, O'Neil KT. PMID: 3447166.
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    430. The design of a four-helix bundle protein. Cold Spring Harb Symp Quant Biol. 1987; 52:521-6. DeGrado WF, Regan L, Ho SP. PMID: 3454275.
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    431. Recognition and characterization of calmodulin-binding sequences in peptides and proteins. Methods Enzymol. 1987; 139:455-78. Erickson-Viitanen S, DeGrado WF. PMID: 3587035.
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    432. The design, synthesis, and crystallization of an alpha-helical peptide. Proteins. 1986 Sep; 1(1):16-22. Eisenberg D, Wilcox W, Eshita SM, Pryciak PM, Ho SP, DeGrado WF. PMID: 3449847.
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    433. p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide. J Biol Chem. 1986 Aug 15; 261(23):10695-700. Kauer JC, Erickson-Viitanen S, Wolfe HR, DeGrado WF. PMID: 3733726.
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    434. Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons. J Interferon Res. 1986 Aug; 6(4):417-27. Cheng YS, Becker-Manley MF, Nguyen TD, DeGrado WF, Jonak GJ. PMID: 3095442.
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    435. A predicted structure of calmodulin suggests an electrostatic basis for its function. Proc Natl Acad Sci U S A. 1985 Aug; 82(15):4954-8. O'Neil KT, DeGrado WF. PMID: 3860834; PMCID: PMC390476.
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    436. In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides. Science. 1985 May 31; 228(4703):1096-9. Briggs MS, Gierasch LM, Zlotnick A, Lear JD, DeGrado WF. PMID: 3158076.
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    437. The interaction of calmodulin with amphiphilic peptides. J Biol Chem. 1985 Feb 25; 260(4):2527-34. Cox JA, Comte M, Fitton JE, DeGrado WF. PMID: 2982823.
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    438. The design, synthesis, and characterization of tight-binding inhibitors of calmodulin. J Cell Biochem. 1985; 29(2):83-93. DeGrado WF, Prendergast FG, Wolfe HR, Cox JA. PMID: 4066780.
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    439. Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies. J Biol Chem. 1984 Oct 10; 259(19):12220-5. Chow TP, DeGrado WF, Knight E. PMID: 6480606.
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    440. Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science. 1984 Aug 17; 225(4663):687-93. Persson H, Hennighausen L, Taub R, DeGrado W, Leder P. PMID: 6431612.
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    441. Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine. J Biol Chem. 1984 Apr 25; 259(8):5327-32. Sigal IS, DeGrado WF, Thomas BJ, Petteway SR. PMID: 6425288.
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    442. Posttranslational modification of human T-cell growth factor. Biochem Biophys Res Commun. 1983 Nov 15; 116(3):1049-55. Robb RJ, Kutny RM, Panico M, Morris H, DeGrado WF, Chowdhry V. PMID: 6606428.
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    443. Sequence and structural homologies among type I and type II interferons. Nature. 1982 Nov 25; 300(5890):379-81. DeGrado WF, Wasserman ZR, Chowdhry V. PMID: 6815538.
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    444. Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophys J. 1982 Jan; 37(1):329-38. DeGrado WF, Musso GF, Lieber M, Kaiser ET, Kézdy FJ. PMID: 7055625; PMCID: PMC1329147.
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