William DeGrado, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South, #452V
San Francisco CA 94158
Phone415-476-9679
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    Collapse Biography 
    Collapse Awards and Honors
    1988Du Vigneaud Award for Young Investigators in Peptide Research
    1989Protein Society Young Investigator Award
    1992Eli Lilly Award in Biological Chemistry
    1993DuPont Merck Summit Award
    1995Fellow, American Association for the Advancement of Science
    1998Fellow, AAAS
    1999Member, National Academy of Sciences (U.S.A.)
    2003Merrifield Award, Peptide Society
    2008Ralph F. Hirschmann Award in Peptide Chemistry (American Chemical Society)
    2009Makineni Award (APS)
    The Protein Society2015The Stein and Moore Award
    Weizmann Institute2016Max Perutz Memorial Lecture
    American Chemical Society2018Cope Scholar Award
    American Chemical Society2018M. Goodman Memorial Prize
    Franklin Institute & City Council of Philadelphia2020John C. Scott Award

    Collapse Overview 
    Collapse Overview
    One research interest is in the de novo design, in which one designs proteins or drugs beginning from first principles. This approach critically tests our understanding of protein folding and function, while also laying the groundwork for the design of molecules with properties unprecedented in nature.

    Collapse Research 
    Collapse Research Activities and Funding
    Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease
    NIH RF1AG061874Sep 30, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Deciphering the relationship between structure, dynamics and function in helical bundle proteins
    NIH R35GM122603May 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH UH3HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH UH2HL123423Sep 1, 2014 - Jul 14, 2016
    Role: Co-Principal Investigator
    Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER
    NIH R01AI097051Mar 1, 2012 - Feb 28, 2018
    Role: Co-Principal Investigator
    Development of drugs that target the M2 proton channel from the influenza A Virus
    NIH U01AI074571May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Design and mechanistic studies of mimics of antimicrobial peptides
    NIH R56AI074866Apr 15, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Design and mechanistic studies of mimics of antimicrobial peptides
    NIH R01AI074866Apr 15, 2008 - Jul 31, 2013
    Role: Principal Investigator
    Proteomics to Biomimetic Polymers: Engineering Principle
    NIH R01EB002048Sep 24, 2002 - Aug 31, 2007
    Role: Principal Investigator
    Proteomics to Biomimetic Polymers: Engineering Principle
    NIH R01GM065803Sep 24, 2002 - Aug 31, 2006
    Role: Principal Investigator
    An Undulator Resource for Structural Biology
    NIH P41RR015301Jun 15, 2001 - Mar 31, 2013
    Role: Co-Investigator
    Bioorganic models for transmembrane proteins
    NIH R01GM060610Dec 1, 1999 - Apr 30, 2010
    Role: Principal Investigator
    Structure of M2 Proton Channel from Influenza A Virus
    NIH R01GM056423Aug 1, 1997 - Apr 30, 2017
    Role: Principal Investigator
    PURCHASE OF ANALYTICAL ULTRACENTRIFUGE
    NIH S10RR011854Mar 18, 1997 - Mar 17, 1998
    Role: Principal Investigator
    De Novo Design of Alpha-Helical Bundles
    NIH R01GM054616Aug 1, 1996 - Jun 30, 2018
    Role: Principal Investigator
    De novo design of alpha-helical bundles
    NIH R37GM054616Aug 1, 1996 - Jul 31, 2014
    Role: Principal Investigator
    Principles of Energy Transduction in Proteins
    NIH P01GM048130Aug 1, 1993 - Jul 31, 2010
    Role: Co-Investigator
    High Performance Computing for Biomedical Research
    NIH P41RR006009Sep 1, 1990 - Jul 31, 2013
    Role: Co-Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    ULTRAFAST OPTICAL PROCESSES LABORATORY
    NIH P41RR001348Aug 1, 1982 - May 31, 2012
    Role: Co-Investigator
    Degenerative and Dementing Diseases of Aging
    NIH P01AG002132Jan 1, 1981 - Mar 31, 2025
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs. bioRxiv. 2024 Sep 02. Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE. PMID: 39282355; PMCID: PMC11398390.
      View in: PubMed   Mentions:
    2. SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex. J Am Chem Soc. 2024 Sep 11; 146(36):25047-25057. Schnaider L, Tan S, Singh PR, Capuano F, Scott AJ, Hambley R, Lu L, Yang H, Wallace EJ, Jo H, DeGrado WF. PMID: 39190920.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2401251121. Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB. PMID: 39136993; PMCID: PMC11348015.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats. Proc Natl Acad Sci U S A. 2024 Jul 30; 121(31):e2220020121. Celona B, Salomonsson SE, Wu H, Dang B, Kratochvil HT, Clelland CD, DeGrado WF, Black BL. PMID: 39042693; PMCID: PMC11295049.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. ProBASS - a language model with sequence and structural features for predicting the effect of mutations on binding affinity. bioRxiv. 2024 Jun 26. Gurusinghe SNS, Wu Y, DeGrado W, Shifman JM. PMID: 38979193; PMCID: PMC11230163.
      View in: PubMed   Mentions:
    6. Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024 Jun 06; 187(12):3072-3089.e20. Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. PMID: 38781967; PMCID: PMC11166531.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle. bioRxiv. 2024 May 01. Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB. PMID: 38746410; PMCID: PMC11092608.
      View in: PubMed   Mentions:
    8. De novo design of drug-binding proteins with predictable binding energy and specificity. Science. 2024 Apr 05; 384(6691):106-112. Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF. PMID: 38574125; PMCID: PMC11290694.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. De novo design of peptides that bind specific conformers of α-synuclein. Chem Sci. 2024 Jun 05; 15(22):8414-8421. Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF. PMID: 38846390; PMCID: PMC11151861.
      View in: PubMed   Mentions: 1  
    10. De novo-designed transmembrane proteins bind and regulate a cytokine receptor. Nat Chem Biol. 2024 Jun; 20(6):751-760. Mravic M, He L, Kratochvil HT, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF. PMID: 38480980; PMCID: PMC11142920.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. An enhanced broad-spectrum peptide inhibits Omicron variants in vivo. Cell Rep Med. 2024 Feb 20; 5(2):101418. Bi W, Tang K, Chen G, Xie Y, Polizzi NF, DeGrado WF, Yuan S, Dang B. PMID: 38340726; PMCID: PMC10897629.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Docking for Molecules That Bind in a Symmetric Stack with SymDOCK. J Chem Inf Model. 2024 01 22; 64(2):425-434. Smith MS, Knight IS, Kormos RC, Pepe JG, Kunach P, Diamond MI, Shahmoradian SH, Irwin JJ, DeGrado WF, Shoichet BK. PMID: 38191997; PMCID: PMC10806807.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    13. De novo design of drug-binding proteins with predictable binding energy and specificity. bioRxiv. 2023 Dec 23. Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF. PMID: 38187746; PMCID: PMC10769398.
      View in: PubMed   Mentions:
    14. De novo Design of Peptides that Bind Specific Conformers of α-Synuclein. bioRxiv. 2023 Nov 16. Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF. PMID: 38014268; PMCID: PMC10680688.
      View in: PubMed   Mentions:
    15. Docking for molecules that bind in a symmetric stack with SymDOCK. bioRxiv. 2023 Oct 29. Smith MS, Knight IS, Kormos RC, Pepe JG, Kunach P, Diamond MI, Shahmoradian SH, Irwin JJ, DeGrado WF, Shoichet BK. PMID: 37961414; PMCID: PMC10634874.
      View in: PubMed   Mentions: 1  
    16. Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface. Protein Sci. 2023 10; 32(10):e4755. Somberg NH, Medeiros-Silva J, Jo H, Wang J, DeGrado WF, Hong M. PMID: 37632140; PMCID: PMC10503410.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023 Aug 15. Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. PMID: 37425793; PMCID: PMC10326967.
      View in: PubMed   Mentions:
    18. Transient water wires mediate selective proton transport in designed channel proteins. Nat Chem. 2023 07; 15(7):1012-1021. Kratochvil HT, Watkins LC, Mravic M, Thomaston JL, Nicoludis JM, Somberg NH, Liu L, Hong M, Voth GA, DeGrado WF. PMID: 37308712; PMCID: PMC10475958.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    19. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nat Commun. 2023 05 26; 14(1):3048. Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR. PMID: 37236970; PMCID: PMC10220082.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    20. A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi. Nat Commun. 2023 04 12; 14(1):2052. Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH. PMID: 37045836; PMCID: PMC10090755.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    21. EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. Proc Natl Acad Sci U S A. 2023 03 21; 120(12):e2300769120. Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. PMID: 36927157; PMCID: PMC10041141.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    22. Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology. bioRxiv. 2023 Feb 15. Mravic M, He L, Kratochvil H, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF. PMID: 36824741; PMCID: PMC9949092.
      View in: PubMed   Mentions:
    23. EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. bioRxiv. 2023 Feb 03. Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. PMID: 36778268; PMCID: PMC9915571.
      View in: PubMed   Mentions:
    24. Aβ and Tau Prions Causing Alzheimer's Disease. Methods Mol Biol. 2023; 2561:293-337. Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB. PMID: 36399277.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    25. Solution of the protein structure prediction problem at last: crucial innovations and next frontiers. Fac Rev. 2022; 11:38. Agard DA, Bowman GR, DeGrado W, Dokholyan NV, Zhou HX. PMID: 36644294; PMCID: PMC9815721.
      View in: PubMed   Mentions: 1  
    26. SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers. Biochemistry. 2022 11 01; 61(21):2280-2294. Somberg NH, Wu WW, Medeiros-Silva J, Dregni AJ, Jo H, DeGrado WF, Hong M. PMID: 36219675; PMCID: PMC9583936.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    27. Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 2022 06; 29(6):537-548. Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL. PMID: 35655098; PMCID: PMC9809158.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    28. Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides. Chem Sci. 2022 Jun 07; 13(22):6599-6609. Zhang MY, Yang H, Ortiz G, Trnka MJ, Petronikolou N, Burlingame AL, DeGrado WF, Fujimori DG. PMID: 35756531; PMCID: PMC9172573.
      View in: PubMed   Mentions: 9  
    29. The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling. J Exp Med. 2022 05 02; 219(5). Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL. PMID: 35320345; PMCID: PMC8953085.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Brilacidin, a COVID-19 drug candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell. J Med Virol. 2022 05; 94(5):2188-2200. Hu Y, Jo H, DeGrado WF, Wang J. PMID: 35080027; PMCID: PMC8930451.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    31. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF. PMID: 35082148; PMCID: PMC8812518.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior. J Am Chem Soc. 2022 01 19; 144(2):769-776. Watkins LC, DeGrado WF, Voth GA. PMID: 34985907; PMCID: PMC8834648.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    33. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathol Commun. 2021 12 27; 9(1):201. Maxwell AM, Yuan P, Rivera BM, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C. PMID: 34961556; PMCID: PMC8711167.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    34. Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides. Faraday Discuss. 2021 12 24; 232(0):9-48. Kratochvil HT, Newberry RW, Mensa B, Mravic M, DeGrado WF. PMID: 34693965; PMCID: PMC8979563.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Theoretical and experimental comparisons of simple peptide-membrane systems; towards defining the reaction space: general discussion. Faraday Discuss. 2021 12 24; 232(0):149-171. Aguilar MI, Al Nahas K, Barrera FN, Bassereau P, Bechinger B, Brand I, Chattopadhyay A, Clarke RJ, DeGrado WF, Deplazes E, Fletcher M, Fraternali F, Fuchs P, Garcia-Saez AJ, Gilbert R, Hoogenboom BW, Jarin Z, O'Shea P, Pabst G, Pal S, Sanderson JM, Seddon JM, Sengupta D, Siegel DP, Srivastava A, Tieleman DP, Tripathy M, Utterström J, Vácha R, Vanni S, Voth GA. PMID: 34908093.
      View in: PubMed   Mentions:    Fields:    
    36. Theoretical and experimental studies of complex peptide-membrane systems: general discussion. Faraday Discuss. 2021 12 24; 232(0):256-281. Aguilar M, Al Nahas K, Barrera F, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chattopadhyay A, Clarke RJ, DeGrado W, Deplazes E, Garcia Saez AJ, Hoogenboom B, Lund R, Milán Rodríguez P, O'Shea P, Pabst G, Pal S, Roux A, Sanderson J, Semeraro EF, Sengupta D, Siegel DP, van 't Hag L, Vijayakumar A, Zoranic L. PMID: 34909814.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    37. Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion. Faraday Discuss. 2021 12 24; 232(0):375-398. Aguilar M, Al Nahas K, Barrera F, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chattopadhyay A, DeGrado W, Fuchs P, Garcia Saez AJ, Hoogenboom B, Kapoor S, Milán Rodríguez P, Molloy J, O'Shea P, Pabst G, Pal S, Rice A, Roux A, Sanderson J, Seddon J, Tamm LK, Vijayakumar A. PMID: 34909817.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    38. Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ. Elife. 2021 12 14; 10. Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF. PMID: 34904568; PMCID: PMC8719878.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    39. Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction. Blood Adv. 2021 12 14; 5(23):4901-4909. Fong KP, Molnar KS, Agard N, Litvinov RI, Kim OV, Wells JA, Weisel JW, DeGrado WF, Bennett JS. PMID: 34570183; PMCID: PMC9153048.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. De novo metalloprotein design. Nat Rev Chem. 2022 Jan; 6(1):31-50. Chalkley MJ, Mann SI, DeGrado WF. PMID: 35811759; PMCID: PMC9264687.
      View in: PubMed   Mentions: 26     Fields:    
    41. Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry. 2021 Aug 03. Thomaston JL, Samways ML, Konstantinidi A, Ma C, Hu Y, Bruce Macdonald HE, Wang J, Essex JW, DeGrado WF, Kolocouris A. PMID: 34342217; PMCID: PMC8810914.
      View in: PubMed   Mentions: 4     Fields:    
    42. Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). Fong LK, Chalkley MJ, Tan SK, Grabe M, DeGrado WF. PMID: 34155106; PMCID: PMC8256006.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    43. Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. J Clin Invest. 2021 06 15; 131(12). Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. PMID: 33956668; PMCID: PMC8203456.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid. Biochemistry. 2021 06 01; 60(21):1722-1730. Fong KP, Ahmed IA, Mravic M, Jo H, Kim OV, Litvinov RI, Weisel JW, DeGrado WF, Gai F, Bennett JS. PMID: 34010565.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    45. Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy. J Am Chem Soc. 2021 05 26; 143(20):7839-7851. Dregni AJ, Wang HK, Wu H, Duan P, Jin J, DeGrado WF, Hong M. PMID: 33983722; PMCID: PMC8283780.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    46. Constructing ion channels from water-soluble α-helical barrels. Nat Chem. 2021 07; 13(7):643-650. Scott AJ, Niitsu A, Kratochvil HT, Lang EJM, Sengel JT, Dawson WM, Mahendran KR, Mravic M, Thomson AR, Brady RL, Liu L, Mulholland AJ, Bayley H, DeGrado WF, Wallace MI, Woolfson DN. PMID: 33972753; PMCID: PMC7611114.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    47. Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR. PMID: 33723045; PMCID: PMC8000134.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    48. Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site. J Am Chem Soc. 2021 03 10; 143(9):3330-3339. Naudin EA, McEwen AG, Tan SK, Poussin-Courmontagne P, Schmitt JL, Birck C, DeGrado WF, Torbeev V. PMID: 33635059; PMCID: PMC8012002.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    49. De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species. J Am Chem Soc. 2021 01 13; 143(1):252-259. Mann SI, Nayak A, Gassner GT, Therien MJ, DeGrado WF. PMID: 33373215; PMCID: PMC8006777.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    50. Allosteric cooperation in a de novo-designed two-domain protein. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33246-33253. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF. PMID: 33318174; PMCID: PMC7776816.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    51. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. J Am Chem Soc. 2020 12 23; 142(51):21310-21321. Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB. PMID: 33301681; PMCID: PMC7790458.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    52. Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395; PMCID: PMC7700746.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    53. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. J Am Chem Soc. 2020 10 14; 142(41):17425-17433. Watkins LC, DeGrado WF, Voth GA. PMID: 32933245; PMCID: PMC7564090.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    54. Prion biology: implications for Alzheimer's disease therapeutics. Lancet Neurol. 2020 10; 19(10):802-803. Condello C, DeGrado WF, Prusiner SB. PMID: 32949533.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 2020 09 04; 369(6508):1227-1233. Polizzi NF, DeGrado WF. PMID: 32883865; PMCID: PMC7526616.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    56. Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289; PMCID: PMC7442712.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    57. Deep mutational scanning reveals the structural basis for α-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544; PMCID: PMC7339969.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    58. De novo protein design, a retrospective. Q Rev Biophys. 2020 02 11; 53:e3. Korendovych IV, DeGrado WF. PMID: 32041676; PMCID: PMC7243446.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    59. X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry. 2020 02 04; 59(4):627-634. Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A. PMID: 31894969; PMCID: PMC7224692.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    60. De novo design of a homo-trimeric amantadine-binding protein. Elife. 2019 12 19; 8. Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. PMID: 31854299; PMCID: PMC6922598.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    61. A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. J Biol Chem. 2019 11 29; 294(48):18232-18243. Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. PMID: 31640988; PMCID: PMC6885615.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    62. In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16357-16366. Dregni AJ, Mandala VS, Wu H, Elkins MR, Wang HK, Hung I, DeGrado WF, Hong M. PMID: 31358628; PMCID: PMC6697781.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    63. Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel. J Am Chem Soc. 2019 07 24; 141(29):11667-11676. Watkins LC, Liang R, Swanson JMJ, DeGrado WF, Voth GA. PMID: 31264413; PMCID: PMC6768079.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    64. Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts. Biochemistry. 2019 07 30; 58(30):3251-3259. Tan SK, Fong KP, Polizzi NF, Sternisha A, Slusky JSG, Yoon K, DeGrado WF, Bennett JS. PMID: 31264850; PMCID: PMC7405930.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    65. X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case. J Am Chem Soc. 2019 07 24; 141(29):11481-11488. Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF. PMID: 31184871; PMCID: PMC7405929.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    66. Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12295-12300. Litvinov RI, Mravic M, Zhu H, Weisel JW, DeGrado WF, Bennett JS. PMID: 31160446; PMCID: PMC6589676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    67. Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. J Am Chem Soc. 2019 05 15; 141(19):7698-7703. Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado WF, Wang Q, Wang PG, Wang L. PMID: 31038942; PMCID: PMC6556376.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    68. Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Sci Transl Med. 2019 05 01; 11(490). Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. PMID: 31043574; PMCID: PMC6640844.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    69. Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chem Commun (Camb). 2019 Apr 25; 55(35):5095-5098. Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. PMID: 30957824; PMCID: PMC6508085.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    70. Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. J Am Chem Soc. 2019 05 08; 141(18):7320-7326. Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. PMID: 30998340; PMCID: PMC6800148.
      View in: PubMed   Mentions: 6     Fields:    
    71. De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities. Acc Chem Res. 2019 05 21; 52(5):1148-1159. Lombardi A, Pirro F, Maglio O, Chino M, DeGrado WF. PMID: 30973707; PMCID: PMC7362765.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    72. Packing of apolar side chains enables accurate design of highly stable membrane proteins. Science. 2019 03 29; 363(6434):1418-1423. Mravic M, Thomaston JL, Tucker M, Solomon PE, Liu L, DeGrado WF. PMID: 30923216; PMCID: PMC7380683.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    73. SNAC-tag for sequence-specific chemical protein cleavage. Nat Methods. 2019 04; 16(4):319-322. Dang B, Mravic M, Hu H, Schmidt N, Mensa B, DeGrado WF. PMID: 30923372; PMCID: PMC6443254.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    74. Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study. J Phys Chem B. 2019 02 28; 123(8):1797-1807. Acharyya A, Ge Y, Wu H, DeGrado WF, Voelz VA, Gai F. PMID: 30694671; PMCID: PMC6497059.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    75. 4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics. Molecules. 2019 Feb 08; 24(3). Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F. PMID: 30744004; PMCID: PMC6384856.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    76. Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations. Cancer Cell. 2018 11 12; 34(5):792-806.e5. Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S. PMID: 30449325; PMCID: PMC6248889.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    77. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):11162-11167. Yang B, Wu H, Schnier PD, Liu Y, Liu J, Wang N, DeGrado WF, Wang L. PMID: 30322930; PMCID: PMC6217395.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    78. Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J Am Chem Soc. 2018 11 14; 140(45):15219-15226. Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF. PMID: 30165017; PMCID: PMC6497056.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    79. Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster. Biopolymers. 2018 Aug; 109(10):e23339. Chino M, Zhang SQ, Pirro F, Leone L, Maglio O, Lombardi A, DeGrado WF. PMID: 30203532; PMCID: PMC6218314.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    80. Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. Angew Chem Int Ed Engl. 2018 09 24; 57(39):12702-12706. Liu J, Cheng R, Wu H, Li S, Wang PG, DeGrado WF, Rozovsky S, Wang L. PMID: 30118570; PMCID: PMC6169525.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    81. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523; PMCID: PMC6584023.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    82. Designed peptides that assemble into cross-α amyloid-like structures. Nat Chem Biol. 2018 09; 14(9):870-875. Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. PMID: 30061717; PMCID: PMC6497057.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    83. Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus. J Am Chem Soc. 2018 06 20; 140(24):7471-7485. Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters JM, Schmidt N, Pelton JG, Gross CA, Meiler J, DeGrado WF. PMID: 29771498; PMCID: PMC6499544.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    84. Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity. ACS Nano. 2018 07 24; 12(7):6554-6562. Kang ES, Kim YT, Ko YS, Kim NH, Cho G, Huh YH, Kim JH, Nam J, Thach TT, Youn D, Kim YD, Yun WS, DeGrado WF, Kim SY, Hammond PT, Lee J, Kwon YU, Ha DH, Kim YH. PMID: 29842775; PMCID: PMC6556112.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    85. De novo designed transmembrane peptides activating the α5β1 integrin. Protein Eng Des Sel. 2018 05 01; 31(5):181-190. Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF. PMID: 29992271; PMCID: PMC6151875.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    86. Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle. Chembiochem. 2018 05 04; 19(9):902-906. Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF. PMID: 29417711; PMCID: PMC6512792.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    87. De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. J Am Chem Soc. 2018 01 31; 140(4):1294-1304. Zhang SQ, Chino M, Liu L, Tang Y, Hu X, DeGrado WF, Lombardi A. PMID: 29249157; PMCID: PMC5860638.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    88. A long-lived Aβ oligomer resistant to fibrillization. Biopolymers. 2018 Aug; 109(8):e23096. Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF. PMID: 29319162; PMCID: PMC6039285.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    89. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E782-E791. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB. PMID: 29311311; PMCID: PMC5789926.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    90. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 12 21; 8(1):2240. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. PMID: 29269770; PMCID: PMC5740110.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    91. Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. Nat Commun. 2017 11 08; 8(1):1365. Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E. PMID: 29118336; PMCID: PMC5678095.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    92. De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10852-10857. Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva DA, Baker D, DeGrado WF. PMID: 28973862; PMCID: PMC5642715.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    93. XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13357-13362. Thomaston JL, Woldeyes RA, Nakane T, Yamashita A, Tanaka T, Koiwai K, Brewster AS, Barad BA, Chen Y, Lemmin T, Uervirojnangkoorn M, Arima T, Kobayashi J, Masuda T, Suzuki M, Sugahara M, Sauter NK, Tanaka R, Nureki O, Tono K, Joti Y, Nango E, Iwata S, Yumoto F, Fraser JS, DeGrado WF. PMID: 28835537; PMCID: PMC5754760.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    94. De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nat Chem. 2017 12; 9(12):1157-1164. Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF. PMID: 29168496; PMCID: PMC5859929.
      View in: PubMed   Mentions: 50     Fields:    
    95. Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport. Philos Trans R Soc Lond B Biol Sci. 2017 08 05; 372(1726). Joh NH, Grigoryan G, Wu Y, DeGrado WF. PMID: 28630154; PMCID: PMC5483517.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    96. Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6191-6196. Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M. PMID: 28566494; PMCID: PMC5474797.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    97. Blue fluorescent amino acid for biological spectroscopy and microscopy. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):6005-6009. Hilaire MR, Ahmed IA, Lin CW, Jo H, DeGrado WF, Gai F. PMID: 28533371; PMCID: PMC5468623.
      View in: PubMed   Mentions: 35     Fields:    
    98. Water Distribution, Dynamics, and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR. J Am Chem Soc. 2017 05 03; 139(17):6242-6252. Wang T, Jo H, DeGrado WF, Hong M. PMID: 28406028; PMCID: PMC5808936.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    99. Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy. Angew Chem Int Ed Engl. 2017 05 02; 56(19):5283-5287. Lin CW, Mensa B, Barniol-Xicota M, DeGrado WF, Gai F. PMID: 28374543; PMCID: PMC5543805.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    100. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem. 2017 09; 9(9):874-881. Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. PMID: 28837163; PMCID: PMC5759337.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    101. Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. PMID: 28278376; PMCID: PMC5481814.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    102. The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases. Protein Sci. 2017 03; 26(3):414-435. Schmidt NW, Grigoryan G, DeGrado WF. PMID: 27977891; PMCID: PMC5326573.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    103. Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032; PMCID: PMC5491273.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    104. An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral Res. 2017 04; 140:45-54. Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J. PMID: 28087313; PMCID: PMC5326599.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    105. Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306; PMCID: PMC5199700.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    106. Acid activation mechanism of the influenza A M2 proton channel. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):E6955-E6964. Liang R, Swanson JMJ, Madsen JJ, Hong M, DeGrado WF, Voth GA. PMID: 27791184; PMCID: PMC5111692.
      View in: PubMed   Mentions: 47     Fields:    
    107. Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. Phys Chem Chem Phys. 2016 Oct 19; 18(41):28939-28950. Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F. PMID: 27725984; PMCID: PMC5157935.
      View in: PubMed   Mentions: 6     Fields:    
    108. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):902-907. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. PMID: 27774126; PMCID: PMC5066160.
      View in: PubMed   Mentions: 7  
    109. Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. J Am Chem Soc. 2016 08 10; 138(31):9840-52. Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M. PMID: 27414264; PMCID: PMC5149419.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    110. Graphene Symmetry Amplified by Designed Peptide Self-Assembly. Biophys J. 2016 06 07; 110(11):2507-2516. Mustata GM, Kim YH, Zhang J, DeGrado WF, Grigoryan G, Wanunu M. PMID: 27276268; PMCID: PMC4906377.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    111. Crystal structure of the drug-resistant S31N influenza M2 proton channel. Protein Sci. 2016 08; 25(8):1551-4. Thomaston JL, DeGrado WF. PMID: 27082171; PMCID: PMC4972211.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    112. Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorg Med Chem Lett. 2016 07 15; 26(14):3359-3363. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X. PMID: 27220724; PMCID: PMC4903891.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    113. Protein-directed self-assembly of a fullerene crystal. Nat Commun. 2016 Apr 26; 7:11429. Kim KH, Ko DK, Kim YT, Kim NH, Paul J, Zhang SQ, Murray CB, Acharya R, DeGrado WF, Kim YH, Grigoryan G. PMID: 27113637; PMCID: PMC4853425.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    114. Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering. J Biol Chem. 2016 May 27; 291(22):11706-16. Fong KP, Zhu H, Span LM, Moore DT, Yoon K, Tamura R, Yin H, DeGrado WF, Bennett JS. PMID: 27056329; PMCID: PMC4882439.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    115. Designed metalloprotein stabilizes a semiquinone radical. Nat Chem. 2016 Apr; 8(4):354-9. Ulas G, Lemmin T, Wu Y, Gassner GT, DeGrado WF. PMID: 27001731; PMCID: PMC4857601.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    116. Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J Med Chem. 2016 Feb 11; 59(3):1207-16. Li F, Ma C, DeGrado WF, Wang J. PMID: 26771709; PMCID: PMC4829348.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    117. High-density grids for efficient data collection from multiple crystals. Acta Crystallogr D Struct Biol. 2016 Jan; 72(Pt 1):2-11. Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. PMID: 26894529; PMCID: PMC4756618.
      View in: PubMed   Mentions: 17  Translation:HumansAnimalsCells
    118. High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14260-5. Thomaston JL, Alfonso-Prieto M, Woldeyes RA, Fraser JS, Klein ML, Fiorin G, DeGrado WF. PMID: 26578770; PMCID: PMC4655559.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    119. Systematic Perturbations of Binuclear Non-heme Iron Sites: Structure and Dioxygen Reactivity of de Novo Due Ferri Proteins. Biochemistry. 2015 Aug 04; 54(30):4637-51. Snyder RA, Betzu J, Butch SE, Reig AJ, DeGrado WF, Solomon EI. PMID: 26154739; PMCID: PMC4857603.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    120. Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins. J Am Chem Soc. 2015 Jul 29; 137(29):9302-14. Snyder RA, Butch SE, Reig AJ, DeGrado WF, Solomon EI. PMID: 26090726; PMCID: PMC4843592.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    121. Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure. Eur J Inorg Chem. 2015 Jul; 2015(21):3371-3390. Chino M, Maglio O, Nastri F, Pavone V, DeGrado WF, Lombardi A. PMID: 27630532; PMCID: PMC5019575.
      View in: PubMed   Mentions: 21  
    122. The αvβ1 integrin plays a critical in vivo role in tissue fibrosis. Sci Transl Med. 2015 May 20; 7(288):288ra79. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. PMID: 25995225; PMCID: PMC4461057.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    123. Signal transduction in histidine kinases: insights from new structures. Structure. 2015 Jun 02; 23(6):981-94. Bhate MP, Molnar KS, Goulian M, DeGrado WF. PMID: 25982528; PMCID: PMC4456306.
      View in: PubMed   Mentions: 117     Fields:    Translation:Cells
    124. The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets. J Biol Chem. 2015 Jun 19; 290(25):15825-15834. Wu Y, Span LM, Nygren P, Zhu H, Moore DT, Cheng H, Roder H, DeGrado WF, Bennett JS. PMID: 25947380; PMCID: PMC4505490.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    125. The membrane- and soluble-protein helix-helix interactome: similar geometry via different interactions. Structure. 2015 Mar 03; 23(3):527-541. Zhang SQ, Kulp DW, Schramm CA, Mravic M, Samish I, DeGrado WF. PMID: 25703378; PMCID: PMC4351763.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    126. Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation. ACS Chem Biol. 2015 Apr 17; 10(4):1082-93. Zhang Y, Bartz R, Grigoryan G, Bryant M, Aaronson J, Beck S, Innocent N, Klein L, Procopio W, Tucker T, Jadhav V, Tellers DM, DeGrado WF. PMID: 25630033; PMCID: PMC4843813.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    127. C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix. Protein Sci. 2015 Mar; 24(3):426-9. Huang S, Green B, Thompson M, Chen R, Thomaston J, DeGrado WF, Howard KP. PMID: 25545360; PMCID: PMC4353368.
      View in: PubMed   Mentions: 9     Fields:    
    128. De novo design of a transmembrane Zn²⁺-transporting four-helix bundle. Science. 2014 Dec 19; 346(6216):1520-4. Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. PMID: 25525248; PMCID: PMC4400864.
      View in: PubMed   Mentions: 136     Fields:    Translation:Cells
    129. Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. J Am Chem Soc. 2014 Dec 31; 136(52):17987-95. Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. PMID: 25470189; PMCID: PMC4286326.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    130. Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly. Biochem J. 2014 Nov 15; 464(1):85-98. Seither KM, McMahon HA, Singh N, Wang H, Cushman-Nick M, Montalvo GL, DeGrado WF, Shorter J. PMID: 25142005; PMCID: PMC4209162.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    131. Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors. J Phys Chem B. 2015 Jan 22; 119(3):1173-83. Gianti E, Carnevale V, DeGrado WF, Klein ML, Fiorin G. PMID: 25353315; PMCID: PMC4386636.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    132. Proton release from the histidine-tetrad in the M2 channel of the influenza A virus. J Phys Chem B. 2014 Nov 06; 118(44):12644-51. Dong H, Fiorin G, DeGrado WF, Klein ML. PMID: 25317959; PMCID: PMC4226308.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    133. Cys-scanning disulfide crosslinking and bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ. Structure. 2014 Sep 02; 22(9):1239-1251. Molnar KS, Bonomi M, Pellarin R, Clinthorne GD, Gonzalez G, Goldberg SD, Goulian M, Sali A, DeGrado WF. PMID: 25087511; PMCID: PMC4322757.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    134. A real-time all-atom structural search engine for proteins. PLoS Comput Biol. 2014 Jul; 10(7):e1003750. Gonzalez G, Hannigan B, DeGrado WF. PMID: 25079944; PMCID: PMC4117414.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    135. Catalytic efficiency of designed catalytic proteins. Curr Opin Struct Biol. 2014 Aug; 27:113-21. Korendovych IV, DeGrado WF. PMID: 25048695; PMCID: PMC4182119.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    136. Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus. J Med Chem. 2014 Jul 10; 57(13):5738-47. Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. PMID: 24941437; PMCID: PMC4096222.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    137. Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. PMID: 24982137; PMCID: PMC4104853.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimals
    138. 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel. J Chem Phys. 2014 Jun 21; 140(23):235105. Ghosh A, Wang J, Moroz YS, Korendovych IV, Zanni M, DeGrado WF, Gai F, Hochstrasser RM. PMID: 24952572; PMCID: PMC4098053.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    139. Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. Antimicrob Agents Chemother. 2014 Sep; 58(9):5136-45. Mensa B, Howell GL, Scott R, DeGrado WF. PMID: 24936592; PMCID: PMC4135847.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    140. Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron. Nat Commun. 2014 Apr 07; 5:3581. Pavone V, Zhang SQ, Merlino A, Lombardi A, Wu Y, DeGrado WF. PMID: 24705140; PMCID: PMC4013780.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    141. Short peptides self-assemble to produce catalytic amyloids. Nat Chem. 2014 Apr; 6(4):303-9. Rufo CM, Moroz YS, Moroz OV, Stöhr J, Smith TA, Hu X, DeGrado WF, Korendovych IV. PMID: 24651196; PMCID: PMC3996680.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansCells
    142. De novo design of self-assembling foldamers that inhibit heparin-protein interactions. ACS Chem Biol. 2014 Apr 18; 9(4):967-75. Montalvo GL, Zhang Y, Young TM, Costanzo MJ, Freeman KB, Wang J, Clements DJ, Magavern E, Kavash RW, Scott RW, Liu D, Degrado WF. PMID: 24491145; PMCID: PMC4324449.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    143. Structural Stability and Binding Strength of a Designed Peptide-Carbon Nanotube Hybrid. J Phys Chem C Nanomater Interfaces. 2013 Dec 12; 117(49):26255-26261. Roxbury D, Zhang SQ, Mittal J, Degrado WF, Jagota A. PMID: 24466357; PMCID: PMC3898491.
      View in: PubMed   Mentions: 4  
    144. Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein. Biochim Biophys Acta. 2014 Apr; 1838(4):1082-7. Polishchuk AL, Cristian L, Pinto LH, Lear JD, DeGrado WF. PMID: 24269540; PMCID: PMC3943701.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    145. Slow folding-unfolding kinetics of an octameric β-peptide bundle. ACS Chem Biol. 2014 Jan 17; 9(1):276-81. Montalvo GL, Gai F, Roder H, DeGrado WF. PMID: 24164344; PMCID: PMC3947042.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    146. Assessment of local friction in protein folding dynamics using a helix cross-linker. J Phys Chem B. 2013 Nov 27; 117(47):14688-96. Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F. PMID: 24205975; PMCID: PMC3904762.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    147. 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. J Med Chem. 2013 Nov 27; 56(22):9265-74. Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. PMID: 24237039; PMCID: PMC3889466.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    148. Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors. Org Biomol Chem. 2013 Nov 07; 11(41):7096-100. Rudick JG, Laakso MM, Schloss AC, DeGrado WF. PMID: 24065278; PMCID: PMC3889485.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    149. Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus. Structure. 2013 Nov 05; 21(11):2033-41. Ma C, Fiorin G, Carnevale V, Wang J, Lamb RA, Klein ML, Wu Y, Pinto LH, DeGrado WF. PMID: 24139991; PMCID: PMC3927992.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    150. Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. J Am Chem Soc. 2013 Sep 18; 135(37):13710-9. Schmidt NW, Mishra A, Wang J, DeGrado WF, Wong GC. PMID: 23962302; PMCID: PMC4000230.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    151. Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore. J Am Chem Soc. 2013 Sep 18; 135(37):13914-26. Fry HC, Lehmann A, Sinks LE, Asselberghs I, Tronin A, Krishnan V, Blasie JK, Clays K, DeGrado WF, Saven JG, Therien MJ. PMID: 23931685; PMCID: PMC3787832.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    152. Nanosecond Dynamics of InfluenzaA/M2TM and an Amantadine Resistant Mutant Probed by Time-Dependent Red Shifts of a Native Tryptophan. Chem Phys. 2013 Aug 30; 422. Nanda V, Cristian L, Toptygin D, Brand L, Degrado WF. PMID: 24273370; PMCID: PMC3833813.
      View in: PubMed   Mentions: 4  
    153. Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular Simulations. J Phys Chem Lett. 2013 Sep 19; 4(18):3067-3071. Dong H, Fiorin G, Degrado WF, Klein ML. PMID: 24069512; PMCID: PMC3779100.
      View in: PubMed   Mentions: 9     Fields:    
    154. Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol. 2013 Oct; 31(10):916-21. Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. PMID: 23955275; PMCID: PMC3795957.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    155. Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR. J Am Chem Soc. 2013 Jul 03; 135(26):9885-97. Williams JK, Tietze D, Wang J, Wu Y, DeGrado WF, Hong M. PMID: 23758317; PMCID: PMC4004037.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    156. Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. J Med Chem. 2013 Apr 11; 56(7):2804-12. Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. PMID: 23437766; PMCID: PMC4036227.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    157. Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. PLoS One. 2013; 8(2):e55271. Balgi AD, Wang J, Cheng DY, Ma C, Pfeifer TA, Shimizu Y, Anderson HJ, Pinto LH, Lamb RA, DeGrado WF, Roberge M. PMID: 23383318; PMCID: PMC3562233.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    158. Assembly of the transmembrane domain of E. coli PhoQ histidine kinase: implications for signal transduction from molecular simulations. PLoS Comput Biol. 2013; 9(1):e1002878. Lemmin T, Soto CS, Clinthorne G, DeGrado WF, Dal Peraro M. PMID: 23359663; PMCID: PMC3554529.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    159. An assay suitable for high throughput screening of anti-influenza drugs. PLoS One. 2013; 8(1):e54070. Mao L, Wang J, DeGrado WF, Inouye M. PMID: 23326573; PMCID: PMC3542334.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    160. Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1315-20. Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF. PMID: 23302696; PMCID: PMC3557100.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    161. Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):678-83. Hu X, Zhao J, DeGrado WF, Binns AN. PMID: 23267119; PMCID: PMC3545744.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    162. Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe. 2012 Dec 13; 12(6):815-23. Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC. PMID: 23245326; PMCID: PMC3638032.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    163. Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling. Protein Sci. 2013 Jan; 22(1):65-73. Thomaston JL, Nguyen PA, Brown EC, Upshur MA, Wang J, DeGrado WF, Howard KP. PMID: 23139077; PMCID: PMC3575861.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    164. Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc. 2012 Oct 24; 134(42):17704-13. Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. PMID: 22998171; PMCID: PMC3523126.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    165. Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Sci. 2012 Nov; 21(11):1620-33. Hong M, DeGrado WF. PMID: 23001990; PMCID: PMC3527700.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    166. Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Nat Chem. 2012 Nov; 4(11):900-6. Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Szyperski TG, Solomon EI, DeGrado WF. PMID: 23089864; PMCID: PMC3568993.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    167. Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions. Structure. 2012 May 09; 20(5):924-35. Schramm CA, Hannigan BT, Donald JE, Keasar C, Saven JG, Degrado WF, Samish I. PMID: 22579257; PMCID: PMC3366090.
      View in: PubMed   Mentions: 42     Fields:    
    168. Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding. J Am Chem Soc. 2012 May 16; 134(19):8026-9. Culik RM, Jo H, DeGrado WF, Gai F. PMID: 22540162; PMCID: PMC3354031.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    169. Computational design of a protein crystal. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7304-9. Lanci CJ, MacDermaid CM, Kang SG, Acharya R, North B, Yang X, Qiu XJ, DeGrado WF, Saven JG. PMID: 22538812; PMCID: PMC3358839.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    170. Inhibition of integrin α2β1 ameliorates glomerular injury. J Am Soc Nephrol. 2012 Jun; 23(6):1027-38. Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. PMID: 22440900; PMCID: PMC3358756.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    171. Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane. J Virol. 2012 Mar; 86(6):2930-41. Montero M, Gulzar N, Klaric KA, Donald JE, Lepik C, Wu S, Tsai S, Julien JP, Hessell AJ, Wang S, Lu S, Burton DR, Pai EF, Degrado WF, Scott JK. PMID: 22238313; PMCID: PMC3302331.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    172. Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):793-8. Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF. PMID: 22210111; PMCID: PMC3271903.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    173. Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):20992-7. Kim YH, Donald JE, Grigoryan G, Leser GP, Fadeev AY, Lamb RA, DeGrado WF. PMID: 22178759; PMCID: PMC3248524.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    174. A photon-free approach to transmembrane protein structure determination. J Mol Biol. 2011 Dec 09; 414(4):596-610. Soto CS, Hannigan BT, DeGrado WF. PMID: 22024595; PMCID: PMC3808161.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    175. Antibacterial mechanism of action of arylamide foldamers. Antimicrob Agents Chemother. 2011 Nov; 55(11):5043-53. Mensa B, Kim YH, Choi S, Scott R, Caputo GA, DeGrado WF. PMID: 21844313; PMCID: PMC3195038.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    176. Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel. J Am Chem Soc. 2011 Sep 07; 133(35):13844-7. Wang J, Ma C, Wu Y, Lamb RA, Pinto LH, DeGrado WF. PMID: 21819109; PMCID: PMC3166227.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    177. Computational design of a β-peptide that targets transmembrane helices. J Am Chem Soc. 2011 Aug 17; 133(32):12378-81. Shandler SJ, Korendovych IV, Moore DT, Smith-Dupont KB, Streu CN, Litvinov RI, Billings PC, Gai F, Bennett JS, DeGrado WF. PMID: 21780757; PMCID: PMC3155016.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    178. Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc. 2011 Aug 17; 133(32):12834-41. Wang J, Ma C, Fiorin G, Carnevale V, Wang T, Hu F, Lamb RA, Pinto LH, Hong M, Klein ML, DeGrado WF. PMID: 21744829; PMCID: PMC3354620.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    179. Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids. Org Lett. 2011 Jul 01; 13(13):3474-7. Korendovych IV, Shandler SJ, Montalvo GL, DeGrado WF. PMID: 21651308; PMCID: PMC3124938.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    180. Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer. Science. 2011 Jun 03; 332(6034):1206-9. Remorino A, Korendovych IV, Wu Y, DeGrado WF, Hochstrasser RM. PMID: 21636774; PMCID: PMC3295544.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    181. Computational design of virus-like protein assemblies on carbon nanotube surfaces. Science. 2011 May 27; 332(6033):1071-6. Grigoryan G, Kim YH, Acharya R, Axelrod K, Jain RM, Willis L, Drndic M, Kikkawa JM, DeGrado WF. PMID: 21617073; PMCID: PMC3264056.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    182. Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus. ACS Med Chem Lett. 2011 Apr 14; 2(4):307-312. Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. PMID: 21691418; PMCID: PMC3116712.
      View in: PubMed   Mentions: 20  
    183. Design of a switchable eliminase. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6823-7. Korendovych IV, Kulp DW, Wu Y, Cheng H, Roder H, DeGrado WF. PMID: 21482808; PMCID: PMC3084051.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    184. Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. J Med Chem. 2011 Apr 28; 54(8):2646-57. Duque MD, Ma C, Torres E, Wang J, Naesens L, Juárez-Jiménez J, Camps P, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. PMID: 21466220; PMCID: PMC3174104.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    185. Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6115-20. Ghosh A, Qiu J, DeGrado WF, Hochstrasser RM. PMID: 21444789; PMCID: PMC3076828.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    186. Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel. Langmuir. 2011 Apr 05; 27(7):3815-21. Rogers JM, Polishchuk AL, Guo L, Wang J, DeGrado WF, Gai F. PMID: 21401044; PMCID: PMC3068240.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    187. Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc. 2011 Mar 30; 133(12):4274-84. Cady SD, Wang J, Wu Y, DeGrado WF, Hong M. PMID: 21381693; PMCID: PMC3078525.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    188. Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment. Angew Chem Int Ed Engl. 2011 Feb 25; 50(9):2049-53. Chakraborty S, Kravitz JY, Thulstrup PW, Hemmingsen L, DeGrado WF, Pecoraro VL. PMID: 21344549; PMCID: PMC3058785.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    189. Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):3958-63. Donald JE, Zhang Y, Fiorin G, Carnevale V, Slochower DR, Gai F, Klein ML, DeGrado WF. PMID: 21321234; PMCID: PMC3054033.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    190. Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Curr Opin Struct Biol. 2011 Feb; 21(1):68-80. Wang J, Qiu JX, Soto C, DeGrado WF. PMID: 21247754; PMCID: PMC3039100.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    191. Salt bridges: geometrically specific, designable interactions. Proteins. 2011 Mar; 79(3):898-915. Donald JE, Kulp DW, DeGrado WF. PMID: 21287621; PMCID: PMC3069487.
      View in: PubMed   Mentions: 124     Fields:    
    192. Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors. Annu Rev Biochem. 2011; 80:211-37. Grigoryan G, Moore DT, DeGrado WF. PMID: 21548783; PMCID: PMC3767166.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    193. NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22481-6. Metcalf DG, Moore DT, Wu Y, Kielec JM, Molnar K, Valentine KG, Wand AJ, Bennett JS, DeGrado WF. PMID: 21156831; PMCID: PMC3012518.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    194. Lipid membranes supported on optically transparent nanosilicas: synthesis and application in characterization of protein-membrane interactions. J Colloid Interface Sci. 2011 Mar 01; 355(1):265-8. Fadeev AY, DeGrado WF. PMID: 21193202; PMCID: PMC4123449.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    195. Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation. Biochemistry. 2010 Dec 14; 49(49):10354-6. Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F. PMID: 21077670; PMCID: PMC2999665.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    196. De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. J Am Chem Soc. 2010 Nov 10; 132(44):15516-8. Korendovych IV, Senes A, Kim YH, Lear JD, Fry HC, Therien MJ, Blasie JK, Walker FA, Degrado WF. PMID: 20945900; PMCID: PMC3016712.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    197. A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein. Biochemistry. 2010 Nov 30; 49(47):10061-71. Polishchuk AL, Lear JD, Ma C, Lamb RA, Pinto LH, Degrado WF. PMID: 20968306; PMCID: PMC3164293.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    198. Role of the conformational rigidity in the design of biomimetic antimicrobial compounds. Angew Chem Int Ed Engl. 2010 Nov 02; 49(45):8462-5. Ivankin A, Livne L, Mor A, Caputo GA, Degrado WF, Meron M, Lin B, Gidalevitz D. PMID: 20872385; PMCID: PMC4112193.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    199. Structural biology. The flu's proton escort. Science. 2010 Oct 22; 330(6003):456-8. Fiorin G, Carnevale V, DeGrado WF. PMID: 20966238; PMCID: PMC3771513.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    200. Multiple Proton Confinement in the M2 Channel from the Influenza A Virus. J Phys Chem C Nanomater Interfaces. 2010 Oct 21; 114(48):20856-20863. Carnevale V, Fiorin G, Levine BG, Degrado WF, Klein ML. PMID: 21359105; PMCID: PMC3045207.
      View in: PubMed   Mentions: 18  
    201. Computational design of a self-assembling β-peptide oligomer. Org Lett. 2010 Nov 19; 12(22):5142-5. Korendovych IV, Kim YH, Ryan AH, Lear JD, Degrado WF, Shandler SJ. PMID: 20945888; PMCID: PMC3807245.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    202. Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface design. J Biol Chem. 2010 Dec 03; 285(49):38658-65. Donald JE, Zhu H, Litvinov RI, DeGrado WF, Bennett JS. PMID: 20929856; PMCID: PMC2992298.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    203. Probing designability via a generalized model of helical bundle geometry. J Mol Biol. 2011 Jan 28; 405(4):1079-100. Grigoryan G, Degrado WF. PMID: 20932976; PMCID: PMC3052747.
      View in: PubMed   Mentions: 112     Fields:    Translation:Cells
    204. The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil. Biophys J. 2010 Oct 06; 99(7):2299-308. Lau WL, Degrado WF, Roder H. PMID: 20923665; PMCID: PMC3042555.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    205. Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15409-14. Leiding T, Wang J, Martinsson J, DeGrado WF, Arsköld SP. PMID: 20713739; PMCID: PMC2932607.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    206. Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15075-80. Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML. PMID: 20689043; PMCID: PMC2930543.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    207. Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy. J Am Chem Soc. 2010 Jul 07; 132(26):9197-205. Su Y, DeGrado WF, Hong M. PMID: 20536141; PMCID: PMC2904348.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    208. Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices. J Mol Biol. 2010 Sep 03; 401(5):882-91. Zhu H, Metcalf DG, Streu CN, Billings PC, Degrado WF, Bennett JS. PMID: 20615419; PMCID: PMC2935666.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    209. Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrob Agents Chemother. 2010 Sep; 54(9):3597-604. Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC. PMID: 20547797; PMCID: PMC2934977.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    210. Development of a rotamer library for use in beta-peptide foldamer computational design. J Am Chem Soc. 2010 Jun 02; 132(21):7312-20. Shandler SJ, Shapovalov MV, Dunbrack RL, DeGrado WF. PMID: 20446685; PMCID: PMC3079439.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    211. Infrared signature and folding dynamics of a helical beta-peptide. J Am Chem Soc. 2010 Apr 28; 132(16):5616-8. Montalvo G, Waegele MM, Shandler S, Gai F, DeGrado WF. PMID: 20373737; PMCID: PMC2862463.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    212. Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8141-6. Goldberg SD, Clinthorne GD, Goulian M, DeGrado WF. PMID: 20404199; PMCID: PMC2889538.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    213. Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore. J Am Chem Soc. 2010 Mar 24; 132(11):3997-4005. Fry HC, Lehmann A, Saven JG, DeGrado WF, Therien MJ. PMID: 20192195; PMCID: PMC2856663.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    214. Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature. 2010 Feb 04; 463(7281):689-92. Cady SD, Schmidt-Rohr K, Wang J, Soto CS, Degrado WF, Hong M. PMID: 20130653; PMCID: PMC2818718.
      View in: PubMed   Mentions: 305     Fields:    Translation:Cells
    215. Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry. 2010 Feb 02; 49(4):696-708. Balannik V, Carnevale V, Fiorin G, Levine BG, Lamb RA, Klein ML, Degrado WF, Pinto LH. PMID: 20028125; PMCID: PMC4924815.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    216. De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. Acc Chem Res. 2010 Jan 19; 43(1):30-9. Tew GN, Scott RW, Klein ML, Degrado WF. PMID: 19813703; PMCID: PMC2808429.
      View in: PubMed   Mentions: 120     Fields:    Translation:Cells
    217. Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. Biochemistry. 2009 Dec 22; 48(50):11872-82. Balannik V, Wang J, Ohigashi Y, Jing X, Magavern E, Lamb RA, Degrado WF, Pinto LH. PMID: 19905033; PMCID: PMC2794939.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    218. Consensus motif for integrin transmembrane helix association. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):703-8. Berger BW, Kulp DW, Span LM, DeGrado JL, Billings PC, Senes A, Bennett JS, DeGrado WF. PMID: 20080739; PMCID: PMC2818961.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    219. Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity. Pflugers Arch. 2010 Mar; 459(4):593-605. Balannik V, Obrdlik P, Inayat S, Steensen C, Wang J, Rausch JM, DeGrado WF, Kelety B, Pinto LH. PMID: 19946785; PMCID: PMC3428792.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    220. An artificial di-iron oxo-protein with phenol oxidase activity. Nat Chem Biol. 2009 Dec; 5(12):882-4. Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A. PMID: 19915535; PMCID: PMC3808167.
      View in: PubMed   Mentions: 71     Fields:    Translation:Cells
    221. A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis. Am J Pathol. 2009 Sep; 175(3):1338-47. San Antonio JD, Zoeller JJ, Habursky K, Turner K, Pimtong W, Burrows M, Choi S, Basra S, Bennett JS, DeGrado WF, Iozzo RV. PMID: 19700757; PMCID: PMC2731151.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    222. Experimental and computational evaluation of forces directing the association of transmembrane helices. J Am Chem Soc. 2009 Aug 19; 131(32):11341-3. Zhang Y, Kulp DW, Lear JD, DeGrado WF. PMID: 19722646.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    223. Engineering and design: editorial overview. Curr Opin Struct Biol. 2009 Aug; 19(4):440-1. Kuhlman B, DeGrado WF. PMID: 19683427; PMCID: PMC3767162.
      View in: PubMed   Mentions:    Fields:    
    224. Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens. J Bacteriol. 2009 Sep; 191(18):5802-13. He F, Nair GR, Soto CS, Chang Y, Hsu L, Ronzone E, DeGrado WF, Binns AN. PMID: 19633083; PMCID: PMC2737963.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    225. Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12283-8. Ma C, Polishchuk AL, Ohigashi Y, Stouffer AL, Schön A, Magavern E, Jing X, Lear JD, Freire E, Lamb RA, DeGrado WF, Pinto LH. PMID: 19590009; PMCID: PMC2718339.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    226. Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc. 2009 Jun 17; 131(23):8066-76. Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M. PMID: 19469531; PMCID: PMC3807247.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    227. Engineered single- and multi-cell chemotaxis pathways in E. coli. Mol Syst Biol. 2009; 5:283. Goldberg SD, Derr P, DeGrado WF, Goulian M. PMID: 19536206; PMCID: PMC2710872.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    228. Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer. J Mol Biol. 2009 Oct 02; 392(4):1087-101. Metcalf DG, Kulp DW, Bennett JS, DeGrado WF. PMID: 19527732; PMCID: PMC3856686.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    229. De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):6968-73. Choi S, Isaacs A, Clements D, Liu D, Kim H, Scott RW, Winkler JD, DeGrado WF. PMID: 19359494; PMCID: PMC2667368.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    230. Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide. J Am Chem Soc. 2009 Mar 25; 131(11):3816-7. Tang J, Yin H, Qiu J, Tucker MJ, DeGrado WF, Gai F. PMID: 19256494; PMCID: PMC2667230.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    231. Metal-binding dependent disruption of membranes by designed helices. J Am Chem Soc. 2009 Mar 11; 131(9):3377-84. Signarvic RS, Degrado WF. PMID: 19209932; PMCID: PMC3774282.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    232. A one-dimensional free energy surface does not account for two-probe folding kinetics of protein alpha(3)D. J Chem Phys. 2009 Feb 14; 130(6):061101. Liu F, Dumont C, Zhu Y, DeGrado WF, Gai F, Gruebele M. PMID: 19222256; PMCID: PMC2671193.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    233. Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1069-74. Khurana E, Dal Peraro M, DeVane R, Vemparala S, DeGrado WF, Klein ML. PMID: 19144924; PMCID: PMC2626606.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
    234. Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):719-24. Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn ML, Bennett JS, DeGrado WF. PMID: 19141632; PMCID: PMC2625282.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    235. Spectroscopic definition of the biferrous and biferric sites in de novo designed four-helix bundle DFsc peptides: implications for O2 reactivity of binuclear non-heme iron enzymes. Biochemistry. 2009 Jan 13; 48(1):59-73. Bell CB, Calhoun JR, Bobyr E, Wei PP, Hedman B, Hodgson KO, Degrado WF, Solomon EI. PMID: 19090676; PMCID: PMC2660568.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    236. The role of hydrophobicity in the antimicrobial and hemolytic activities of polymethacrylate derivatives. Chemistry. 2009; 15(5):1123-33. Kuroda K, Caputo GA, DeGrado WF. PMID: 19072946; PMCID: PMC3814040.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    237. Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion. J Mol Biol. 2009 Feb 13; 386(1):14-36. Bissonnette ML, Donald JE, DeGrado WF, Jardetzky TS, Lamb RA. PMID: 19121325; PMCID: PMC2750892.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    238. De novo designed synthetic mimics of antimicrobial peptides. Curr Opin Biotechnol. 2008 Dec; 19(6):620-7. Scott RW, DeGrado WF, Tew GN. PMID: 18996193; PMCID: PMC2646611.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    239. Species differences in small molecule binding to alpha IIb beta 3 are the result of sequence differences in 2 loops of the alpha IIb beta propeller. Blood. 2009 Jan 22; 113(4):902-10. Basani RB, Zhu H, Thornton MA, Soto CS, Degrado WF, Kowalska MA, Bennett JS, Poncz M. PMID: 18987357; PMCID: PMC2630275.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    240. Investigation of an unnatural amino acid for use as a resonance Raman probe: Detection limits, solvent and temperature dependence of the νC≡N band of 4-cyanophenylalanine. J Raman Spectrosc. 2008 Nov; 39(11):1606-1613. Weeks CL, Polishchuk A, Getahun Z, Degrado WF, Spiro TG. PMID: 20648227; PMCID: PMC2905815.
      View in: PubMed   Mentions: 16  
    241. pH-induced conformational change of the influenza M2 protein C-terminal domain. Biochemistry. 2008 Sep 23; 47(38):9934-6. Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, DeGrado WF, Howard KP. PMID: 18754675; PMCID: PMC2746938.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    242. Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays. J Am Chem Soc. 2008 Sep 10; 130(36):11921-7. McAllister KA, Zou H, Cochran FV, Bender GM, Senes A, Fry HC, Nanda V, Keenan PA, Lear JD, Saven JG, Therien MJ, Blasie JK, DeGrado WF. PMID: 18710226; PMCID: PMC3663296.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    243. Computationally designed peptide inhibitors of protein-protein interactions in membranes. Biochemistry. 2008 Aug 19; 47(33):8600-6. Caputo GA, Litvinov RI, Li W, Bennett JS, Degrado WF, Yin H. PMID: 18642886; PMCID: PMC2719017.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    244. New design of helix bundle peptide-polymer conjugates. Biomacromolecules. 2008 Aug; 9(8):2111-7. Shu JY, Tan C, DeGrado WF, Xu T. PMID: 18627200; PMCID: PMC3815612.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    245. Modest membrane hydrogen bonds deliver rich results. Nat Chem Biol. 2008 Jul; 4(7):393-4. Grigoryan G, Degrado WF. PMID: 18560430; PMCID: PMC2721465.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    246. Protein-protein interactions in the membrane: sequence, structural, and biological motifs. Structure. 2008 Jul; 16(7):991-1001. Moore DT, Berger BW, DeGrado WF. PMID: 18611372; PMCID: PMC3771515.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    247. The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure. 2008 Jul; 16(7):1067-76. Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF. PMID: 18611380; PMCID: PMC2594009.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    248. Oxygen reactivity of the biferrous site in the de novo designed four helix bundle peptide DFsc: nature of the "intermediate" and reaction mechanism. J Am Chem Soc. 2008 Jul 23; 130(29):9188-9. Calhoun JR, Bell CB, Smith TJ, Thamann TJ, DeGrado WF, Solomon EI. PMID: 18572936; PMCID: PMC3810014.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    249. Determination of the physiological dimer interface of the PhoQ sensor domain. J Mol Biol. 2008 Jun 13; 379(4):656-65. Goldberg SD, Soto CS, Waldburger CD, Degrado WF. PMID: 18468622; PMCID: PMC2542651.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    250. Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus. J Biol Chem. 2008 Jun 06; 283(23):15921-31. Ma C, Soto CS, Ohigashi Y, Taylor A, Bournas V, Glawe B, Udo MK, Degrado WF, Lamb RA, Pinto LH. PMID: 18408016; PMCID: PMC2414288.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    251. Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. Structure. 2008 Feb; 16(2):210-5. Calhoun JR, Liu W, Spiegel K, Dal Peraro M, Klein ML, Valentine KG, Wand AJ, DeGrado WF. PMID: 18275812; PMCID: PMC3814030.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    252. Structural basis for the function and inhibition of an influenza virus proton channel. Nature. 2008 Jan 31; 451(7178):596-9. Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF. PMID: 18235504; PMCID: PMC3889492.
      View in: PubMed   Mentions: 285     Fields:    Translation:Cells
    253. Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers. Biochemistry. 2007 Dec 04; 46(48):13856-63. Tang J, Signarvic RS, DeGrado WF, Gai F. PMID: 17994771.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    254. Small molecule inhibitors of integrin alpha2beta1. J Med Chem. 2007 Nov 01; 50(22):5457-62. Choi S, Vilaire G, Marcinkiewicz C, Winkler JD, Bennett JS, DeGrado WF. PMID: 17915848; PMCID: PMC3828121.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    255. Enthalpic and entropic stages in alpha-helical peptide unfolding, from laser T-jump/UV Raman spectroscopy. J Am Chem Soc. 2007 Oct 24; 129(42):12801-8. Balakrishnan G, Hu Y, Bender GM, Getahun Z, DeGrado WF, Spiro TG. PMID: 17910449; PMCID: PMC2887291.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    256. Site-specific hydration status of an amphipathic peptide in AOT reverse micelles. Langmuir. 2007 Oct 23; 23(22):11174-9. Mukherjee S, Chowdhury P, DeGrado WF, Gai F. PMID: 17910485.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    257. De novo design of a single-chain diphenylporphyrin metalloprotein. J Am Chem Soc. 2007 Sep 05; 129(35):10732-40. Bender GM, Lehmann A, Zou H, Cheng H, Fry HC, Engel D, Therien MJ, Blasie JK, Roder H, Saven JG, DeGrado WF. PMID: 17691729; PMCID: PMC2542652.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    258. Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores. J Phys Chem A. 2007 Aug 02; 111(30):6977-90. Finikova OS, Troxler T, Senes A, DeGrado WF, Hochstrasser RM, Vinogradov SA. PMID: 17608457; PMCID: PMC2441487.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    259. Mutagenesis data in the automated prediction of transmembrane helix dimers. Proteins. 2007 May 01; 67(2):375-84. Metcalf DG, Law PB, DeGrado WF. PMID: 17311347.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    260. Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol. 2007 May; 3(5):252-62. Goodman CM, Choi S, Shandler S, DeGrado WF. PMID: 17438550; PMCID: PMC3810020.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    261. Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. J Am Chem Soc. 2007 May 02; 129(17):5719-29. Cady SD, Goodman C, Tatko CD, DeGrado WF, Hong M. PMID: 17417850.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    262. Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function. J Biomed Mater Res A. 2007 Apr; 81(1):150-60. Lee MH, Adams CS, Boettiger D, Degrado WF, Shapiro IM, Composto RJ, Ducheyne P. PMID: 17111408.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    263. Computational design of peptides that target transmembrane helices. Science. 2007 Mar 30; 315(5820):1817-22. Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. PMID: 17395823.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    264. Interactions of ADP-stimulated human platelets with PEGylated polystyrene substrates prepared by surface amidation. Colloids Surf B Biointerfaces. 2007 Aug 01; 58(2):225-30. Wang PC, Vilaire G, DeGrado WF, Bennett JS. PMID: 17499487.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    265. The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. FEBS J. 2007 Mar; 274(6):1481-91. White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. PMID: 17489103.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    266. Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16740-5. Fang C, Senes A, Cristian L, DeGrado WF, Hochstrasser RM. PMID: 17075037; PMCID: PMC1636525.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    267. Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations. J Struct Biol. 2007 Mar; 157(3):444-53. Dal Peraro M, Spiegel K, Lamoureux G, De Vivo M, DeGrado WF, Klein ML. PMID: 17188512.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    268. Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb. J Biol Chem. 2006 Dec 01; 281(48):36732-41. Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. PMID: 17032655.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    269. Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding. Biochemistry. 2006 Sep 12; 45(36):10981-6. Bunagan MR, Cristian L, DeGrado WF, Gai F. PMID: 16953584.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    270. E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices. J Mol Biol. 2007 Feb 16; 366(2):436-48. Senes A, Chadi DC, Law PB, Walters RF, Nanda V, Degrado WF. PMID: 17174324.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    271. Helix-packing motifs in membrane proteins. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13658-63. Walters RF, DeGrado WF. PMID: 16954199; PMCID: PMC1564267.
      View in: PubMed   Mentions: 120     Fields:    Translation:Cells
    272. The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis. Angew Chem Int Ed Engl. 2006 Jul 24; 45(30):4951-4. Wade H, Stayrook SE, Degrado WF. PMID: 16819737.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    273. Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction. Bioorg Med Chem Lett. 2006 Jul 01; 16(13):3380-2. Yin H, Gerlach LO, Miller MW, Moore DT, Liu D, Vilaire G, Bennett JS, DeGrado WF. PMID: 16678410.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    274. Probing Membrane Insertion Activity of Antimicrobial Polymers via Coarse-grain Molecular Dynamics. J Chem Theory Comput. 2006 May; 2(3):649-655. Lopez CF, Nielsen SO, Srinivas G, Degrado WF, Klein ML. PMID: 18985168; PMCID: PMC2577386.
      View in: PubMed   Mentions: 19     Fields:    
    275. Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides. J Mol Biol. 2006 Jun 16; 359(4):930-9. North B, Cristian L, Fu Stowell X, Lear JD, Saven JG, Degrado WF. PMID: 16697010.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    276. Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering. Biochemistry. 2006 Apr 18; 45(15):4957-64. Litvinov RI, Vilaire G, Li W, DeGrado WF, Weisel JW, Bennett JS. PMID: 16605263.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    277. Polar networks control oligomeric assembly in membranes. J Am Chem Soc. 2006 Apr 05; 128(13):4170-1. Tatko CD, Nanda V, Lear JD, Degrado WF. PMID: 16568959.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    278. Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study. J Phys Chem B. 2006 Mar 02; 110(8):3517-26. Pophristic V, Vemparala S, Ivanov I, Liu Z, Klein ML, DeGrado WF. PMID: 16494407.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    279. Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics. J Am Chem Soc. 2006 Feb 15; 128(6):1778-9. Ivanov I, Vemparala S, Pophristic V, Kuroda K, DeGrado WF, McCammon JA, Klein ML. PMID: 16464062.
      View in: PubMed   Mentions: 17     Fields:    
    280. Computational design of heterochiral peptides against a helical target. J Am Chem Soc. 2006 Jan 25; 128(3):809-16. Nanda V, DeGrado WF. PMID: 16417370.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    281. Arylamide derivatives as peptidomimetic inhibitors of calmodulin. Org Lett. 2006 Jan 19; 8(2):223-5. Yin H, Frederick KK, Liu D, Wand AJ, Degrado WF. PMID: 16408880.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    282. Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography. J Am Chem Soc. 2005 Dec 14; 127(49):17266-76. Geremia S, Di Costanzo L, Randaccio L, Engel DE, Lombardi A, Nastri F, DeGrado WF. PMID: 16332076.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    283. Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. J Am Chem Soc. 2005 Nov 23; 127(46):16098-106. Wei PP, Skulan AJ, Wade H, DeGrado WF, Solomon EI. PMID: 16287296.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    284. Alpha-alpha linking motifs and interhelical orientations. Proteins. 2005 Nov 01; 61(2):325-37. Engel DE, DeGrado WF. PMID: 16104016.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    285. The design and evaluation of heparin-binding foldamers. Angew Chem Int Ed Engl. 2005 Oct 21; 44(41):6685-9. Choi S, Clements DJ, Pophristic V, Ivanov I, Vemparala S, Bennett JS, Klein ML, Winkler JD, DeGrado WF. PMID: 16094685.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    286. An atomic environment potential for use in protein structure prediction. J Mol Biol. 2005 Sep 30; 352(4):986-1001. Summa CM, Levitt M, Degrado WF. PMID: 16126228.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    287. Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops. J Biol Inorg Chem. 2005 Aug; 10(5):539-49. Maglio O, Nastri F, Calhoun JR, Lahr S, Wade H, Pavone V, DeGrado WF, Lombardi A. PMID: 16091937.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    288. T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. Biophys J. 2005 Dec; 89(6):4180-7. Wang T, Lau WL, DeGrado WF, Gai F. PMID: 16150962; PMCID: PMC1366983.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    289. Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion. Biomaterials. 2005 Aug; 26(23):4757-66. Willcox PJ, Reinhart-King CA, Lahr SJ, DeGrado WF, Hammer DA. PMID: 15763255.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    290. Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol. 2005 Jun 28; 5:11. Kovalenko OV, Metcalf DG, DeGrado WF, Hemler ME. PMID: 15985154; PMCID: PMC1190194.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    291. Automated use of mutagenesis data in structure prediction. Proteins. 2005 May 15; 59(3):454-66. Nanda V, DeGrado WF. PMID: 15768404.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    292. Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins. Proteins. 2005 May 15; 59(3):496-509. Adamian L, Nanda V, DeGrado WF, Liang J. PMID: 15789404.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    293. X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils. J Mol Biol. 2005 May 06; 348(3):777-87. Slovic AM, Stayrook SE, North B, Degrado WF. PMID: 15826670.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    294. De novo design of a redox-active minimal rubredoxin mimic. J Am Chem Soc. 2005 Apr 27; 127(16):5804-5. Nanda V, Rosenblatt MM, Osyczka A, Kono H, Getahun Z, Dutton PL, Saven JG, Degrado WF. PMID: 15839675.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    295. Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability. J Mol Biol. 2005 May 20; 348(5):1225-33. Cristian L, Nanda V, Lear JD, DeGrado WF. PMID: 15854657.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    296. Amphiphilic polymethacrylate derivatives as antimicrobial agents. J Am Chem Soc. 2005 Mar 30; 127(12):4128-9. Kuroda K, DeGrado WF. PMID: 15783168.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    297. De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban. J Pept Res. 2005 Mar; 65(3):312-21. Slovic AM, Lear JD, DeGrado WF. PMID: 15787961.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    298. Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Sci. 2005 Apr; 14(4):1019-24. Howard KP, Liu W, Crocker E, Nanda V, Lear J, Degrado WF, Smith SO. PMID: 15741331; PMCID: PMC2253437.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    299. The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Sci. 2005 Apr; 14(4):856-61. Duong-Ly KC, Nanda V, Degrado WF, Howard KP. PMID: 15741338; PMCID: PMC2253456.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    300. Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. J Am Chem Soc. 2005 Feb 09; 127(5):1346-7. Cochran FV, Wu SP, Wang W, Nanda V, Saven JG, Therien MJ, DeGrado WF. PMID: 15686346.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    301. A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1424-9. Li W, Metcalf DG, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear JD, Degrado WF, Bennett JS. PMID: 15671157; PMCID: PMC547819.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    302. Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol. 2005 Mar 18; 347(1):169-79. Stouffer AL, Nanda V, Lear JD, DeGrado WF. PMID: 15733926.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    303. Analysis and design of turns in alpha-helical hairpins. J Mol Biol. 2005 Mar 11; 346(5):1441-54. Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF. PMID: 15713492.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    304. Artificial diiron proteins: from structure to function. Biopolymers. 2005; 80(2-3):264-78. Calhoun JR, Nastri F, Maglio O, Pavone V, Lombardi A, DeGrado WF. PMID: 15700297.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    305. Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. FEBS Lett. 2004 Dec 03; 578(1-2):140-4. Ghirlanda G, Hilcove SA, Pidikiti R, Johansson JS, Lear JD, Degrado WF, Eckenhoff RG. PMID: 15581631.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    306. Simulated evolution of emergent chiral structures in polyalanine. J Am Chem Soc. 2004 Nov 10; 126(44):14459-67. Nanda V, Degrado WF. PMID: 15521766.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    307. Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers. Chemistry. 2004 Oct 11; 10(20):5008-16. Doerksen RJ, Chen B, Liu D, Tew GN, Degrado WF, Klein ML. PMID: 15372664.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    308. Length Dependent Helix-Coil Transition Kinetics of Nine Alanine-Based Peptides. J Phys Chem B. 2004 Sep 30; 108(39). Wang T, Zhu Y, Getahun Z, Du D, Huang CY, Degrado WF, Gai F. PMID: 24307864; PMCID: PMC3845522.
      View in: PubMed   Mentions: 31     Fields:    
    309. Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophys J. 2004 Nov; 87(5):3421-9. Lear JD, Stouffer AL, Gratkowski H, Nanda V, Degrado WF. PMID: 15315956; PMCID: PMC1304808.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    310. De novo design of catalytic proteins. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11566-70. Kaplan J, DeGrado WF. PMID: 15292507; PMCID: PMC511021.
      View in: PubMed   Mentions: 107     Fields:    Translation:Cells
    311. Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 Aug; 14(4):465-79. Senes A, Engel DE, DeGrado WF. PMID: 15313242.
      View in: PubMed   Mentions: 189     Fields:    Translation:Cells
    312. De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1. J Am Chem Soc. 2004 Jul 07; 126(26):8141-7. Ghirlanda G, Osyczka A, Liu W, Antolovich M, Smith KM, Dutton PL, Wand AJ, DeGrado WF. PMID: 15225055.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    313. Structural basis for integrin alphaIIbbeta3 clustering. Biochem Soc Trans. 2004 Jun; 32(Pt3):412-5. Li R, Bennett JS, Degrado WF. PMID: 15157149.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    314. A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. J Am Chem Soc. 2004 Apr 28; 126(16):5078-9. Tucker MJ, Getahun Z, Nanda V, DeGrado WF, Gai F. PMID: 15099085.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    315. Amino acid propensities are position-dependent throughout the length of alpha-helices. J Mol Biol. 2004 Apr 09; 337(5):1195-205. Engel DE, DeGrado WF. PMID: 15046987.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    316. Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem. 2004 Jun 18; 279(25):26666-73. Li R, Gorelik R, Nanda V, Law PB, Lear JD, DeGrado WF, Bennett JS. PMID: 15067009.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    317. Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl. 2004 Feb 20; 43(9):1158-62. Liu D, Choi S, Chen B, Doerksen RJ, Clements DJ, Winkler JD, Klein ML, DeGrado WF. PMID: 14983462.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    318. Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1828-33. Slovic AM, Kono H, Lear JD, Saven JG, DeGrado WF. PMID: 14766985; PMCID: PMC357012.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    319. Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophys J. 2004 Jan; 86(1 Pt 1):272-84. Lau WL, Ege DS, Lear JD, Hammer DA, DeGrado WF. PMID: 14695269; PMCID: PMC1303790.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    320. Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol. 2003 Dec 12; 334(5):1101-15. Calhoun JR, Kono H, Lahr S, Wang W, DeGrado WF, Saven JG. PMID: 14643669.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    321. Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15486-91. Zhu Y, Alonso DO, Maki K, Huang CY, Lahr SJ, Daggett V, Roder H, DeGrado WF, Gai F. PMID: 14671331; PMCID: PMC307594.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    322. Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14772-7. Cristian L, Lear JD, DeGrado WF. PMID: 14657351; PMCID: PMC299801.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    323. De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. J Mol Biol. 2003 Nov 14; 334(1):1-12. Signarvic RS, DeGrado WF. PMID: 14596795.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    324. Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange. Protein Sci. 2003 Aug; 12(8):1732-40. Cristian L, Lear JD, DeGrado WF. PMID: 12876322; PMCID: PMC2323959.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    325. Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry. 2003 Jun 03; 42(21):6400-7. Lear JD, Gratkowski H, Adamian L, Liang J, DeGrado WF. PMID: 12767221.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    326. Computational biology: Biosensor design. Nature. 2003 May 08; 423(6936):132-3. DeGrado WF. PMID: 12736670.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    327. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science. 2003 May 02; 300(5620):795-8. Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, Weisel JW, Lear JD, DeGrado WF, Bennett JS. PMID: 12730600.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    328. How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci. 2003 Apr; 12(4):647-65. DeGrado WF, Gratkowski H, Lear JD. PMID: 12649422; PMCID: PMC2323850.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    329. Preorganization of molecular binding sites in designed diiron proteins. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):3772-7. Maglio O, Nastri F, Pavone V, Lombardi A, DeGrado WF. PMID: 12655072; PMCID: PMC152997.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    330. The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci. 2003 Mar; 12(3):520-31. Walsh ST, Cheng RP, Wright WW, Alonso DO, Daggett V, Vanderkooi JM, DeGrado WF. PMID: 12592022; PMCID: PMC2312439.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    331. Computational design of a water-soluble analog of phospholamban. Protein Sci. 2003 Feb; 12(2):337-48. Slovic AM, Summa CM, Lear JD, DeGrado WF. PMID: 12538897; PMCID: PMC2312418.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    332. Sliding helix and change of coordination geometry in a model di-MnII protein. Angew Chem Int Ed Engl. 2003 Jan 27; 42(4):417-20. DeGrado WF, Di Costanzo L, Geremia S, Lombardi A, Pavone V, Randaccio L. PMID: 12569505.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    333. Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc. 2003 Jan 15; 125(2):405-11. Getahun Z, Huang CY, Wang T, De León B, DeGrado WF, Gai F. PMID: 12517152.
      View in: PubMed   Mentions: 100     Fields:    Translation:Cells
    334. Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor. J Am Chem Soc. 2003 Jan 15; 125(2):560-9. Papoian GA, DeGrado WF, Klein ML. PMID: 12517172.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    335. Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng. 2003 Jan; 16(1):65-72. Li R, Hoess RH, Bennett JS, DeGrado WF. PMID: 12646694.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    336. Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry. 2002 Dec 31; 41(52):15618-24. Li R, Babu CR, Valentine K, Lear JD, Wand AJ, Bennett JS, DeGrado WF. PMID: 12501190.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    337. Light-induced helix formation. J Am Chem Soc. 2002 Oct 30; 124(43):12674-5. Huang CY, He S, DeGrado WF, McCafferty DG, Gai F. PMID: 12392410.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    338. Long-range interactions stabilize the fold of a non-natural oligomer. J Am Chem Soc. 2002 Oct 02; 124(39):11564-5. Cheng RP, DeGrado WF. PMID: 12296699.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    339. Cooperativity and specificity of association of a designed transmembrane peptide. Biophys J. 2002 Sep; 83(3):1613-9. Gratkowski H, Dai QH, Wand AJ, DeGrado WF, Lear JD. PMID: 12202385; PMCID: PMC1302258.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    340. Computational de novo design, and characterization of an A(2)B(2) diiron protein. J Mol Biol. 2002 Aug 30; 321(5):923-38. Summa CM, Rosenblatt MM, Hong JK, Lear JD, DeGrado WF. PMID: 12206771.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    341. Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8568-72. Howard KP, Lear JD, DeGrado WF. PMID: 12084917; PMCID: PMC124313.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    342. A hierarchic approach to the design of hexameric helical barrels. J Mol Biol. 2002 May 24; 319(1):243-53. Ghirlanda G, Lear JD, Ogihara NL, Eisenberg D, DeGrado WF. PMID: 12051949.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    343. De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5110-4. Tew GN, Liu D, Chen B, Doerksen RJ, Kaplan J, Carroll PJ, Klein ML, DeGrado WF. PMID: 11959961; PMCID: PMC122730.
      View in: PubMed   Mentions: 93     Fields:    
    344. Noncovalent self-assembly of a heterotetrameric diiron protein. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5150-4. Marsh EN, DeGrado WF. PMID: 11959963; PMCID: PMC122737.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    345. Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2788-93. Huang CY, Getahun Z, Zhu Y, Klemke JW, DeGrado WF, Gai F. PMID: 11867741; PMCID: PMC122426.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    346. Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. J Am Chem Soc. 2001 Dec 26; 123(51):12749-57. Di Costanzo L, Wade H, Geremia S, Randaccio L, Pavone V, DeGrado WF, Lombardi A. PMID: 11749531.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    347. Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn. J Am Chem Soc. 2001 Dec 19; 123(50):12710-1. Cheng RP, Suich DJ, Cheng H, Roder H, DeGrado WF. PMID: 11741449.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    348. Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides. J Am Chem Soc. 2001 Dec 05; 123(48):12111-2. Huang CY, Getahun Z, Wang T, DeGrado WF, Gai F. PMID: 11724630.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    349. Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12462-7. Li R, Babu CR, Lear JD, Wand AJ, Bennett JS, DeGrado WF. PMID: 11606749; PMCID: PMC60076.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    350. Introduction: protein design. Chem Rev. 2001 Oct 10; 101(10):3025-6. DeGrado WF. PMID: 11749399.
      View in: PubMed   Mentions: 2     Fields:    
    351. beta-Peptides: from structure to function. Chem Rev. 2001 Oct; 101(10):3219-32. Cheng RP, Gellman SH, DeGrado WF. PMID: 11710070.
      View in: PubMed   Mentions: 224     Fields:    Translation:Cells
    352. Temperature-dependent helix-coil transition of an alanine based peptide. J Am Chem Soc. 2001 Sep 26; 123(38):9235-8. Huang CY, Klemke JW, Getahun Z, DeGrado WF, Gai F. PMID: 11562202.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    353. D(n)-symmetrical tertiary templates for the design of tubular proteins. J Mol Biol. 2001 Aug 31; 311(5):1081-90. North B, Summa CM, Ghirlanda G, DeGrado WF. PMID: 11531341.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    354. Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. Biochemistry. 2001 Aug 14; 40(32):9560-9. Walsh ST, Lee AL, DeGrado WF, Wand AJ. PMID: 11583155.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    355. De novo design, synthesis, and characterization of antimicrobial beta-peptides. J Am Chem Soc. 2001 Aug 08; 123(31):7553-9. Liu D, DeGrado WF. PMID: 11480975.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    356. De novo design, synthesis and characterization of membrane-active peptides. Biochem Soc Trans. 2001 Aug; 29(Pt 4):559-64. Lear JD, Gratkowski H, DeGrado WF. PMID: 11498028.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    357. De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions. J Am Chem Soc. 2001 May 30; 123(21):5162-3. Cheng RP, DeGrado WF. PMID: 11457373.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    358. Proton and metal ion-dependent assembly of a model diiron protein. Protein Sci. 2001 May; 10(5):958-69. Pasternak A, Kaplan J, Lear JD, Degrado WF. PMID: 11316876; PMCID: PMC2374189.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    359. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hathaway for performing matrix-assisted laser desorption/ionization analyses. Angew Chem Int Ed Engl. 2001 Apr 17; 40(8):1494-1496. Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. PMID: 11317312.
      View in: PubMed   Mentions: 16     Fields:    
    360. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability. Angew Chem Int Ed Engl. 2001 Apr 17; 40(8):1494-1496. Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. PMID: 29712367.
      View in: PubMed   Mentions: 13     Fields:    
    361. Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. Biochemistry. 2001 Mar 06; 40(9):2790-6. Tang Y, Ghirlanda G, Vaidehi N, Kua J, Mainz DT, Goddard III WA, DeGrado WF, Tirrell DA. PMID: 11258889.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    362. Design of three-dimensional domain-swapped dimers and fibrous oligomers. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1404-9. Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D. PMID: 11171963; PMCID: PMC29269.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    363. Polar side chains drive the association of model transmembrane peptides. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):880-5. Gratkowski H, Lear JD, DeGrado WF. PMID: 11158564; PMCID: PMC14678.
      View in: PubMed   Mentions: 125     Fields:    Translation:Cells
    364. Hydrophobic core malleability of a de novo designed three-helix bundle protein. J Mol Biol. 2001 Jan 12; 305(2):361-73. Walsh ST, Sukharev VI, Betz SF, Vekshin NL, DeGrado WF. PMID: 11124911.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    365. Evolution of binding affinity in a WW domain probed by phage display. Protein Sci. 2000 Dec; 9(12):2366-76. Dalby PA, Hoess RH, DeGrado WF. PMID: 11206058; PMCID: PMC2144528.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    366. pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry. 2000 Nov 21; 39(46):14160-70. Salom D, Hill BR, Lear JD, DeGrado WF. PMID: 11087364; PMCID: PMC3060174.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    367. Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13021-6. Talaga DS, Lau WL, Roder H, Tang J, Jia Y, DeGrado WF, Hochstrasser RM. PMID: 11087856; PMCID: PMC27171.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    368. Structural consequences of an amino acid deletion in the B1 domain of protein G. Proteins. 2000 Nov 15; 41(3):323-33. O'Neil KT, Bach AC, DeGrado WF. PMID: 11025544.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    369. De novo design of helical bundles as models for understanding protein folding and function. Acc Chem Res. 2000 Nov; 33(11):745-54. Hill RB, Raleigh DP, Lombardi A, DeGrado WF. PMID: 11087311; PMCID: PMC3050006.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    370. Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity. Bioorg Med Chem. 2000 Sep; 8(9):2229-41. Suich DJ, Mousa SA, Singh G, Liapakis G, Reisine T, DeGrado WF. PMID: 11026536.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    371. The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin. J Biol Chem. 2000 Jun 16; 275(24):18337-43. Helluin O, Chan C, Vilaire G, Mousa S, DeGrado WF, Bennett JS. PMID: 10751402.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    372. Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6298-305. Lombardi A, Summa CM, Geremia S, Randaccio L, Pavone V, DeGrado WF. PMID: 10841536; PMCID: PMC18597.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
    373. A polar, solvent-exposed residue can be essential for native protein structure. Structure. 2000 May 15; 8(5):471-9. Hill RB, DeGrado WF. PMID: 10801493; PMCID: PMC3050062.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    374. Asparagine-mediated self-association of a model transmembrane helix. Nat Struct Biol. 2000 Feb; 7(2):161-6. Choma C, Gratkowski H, Lear JD, DeGrado WF. PMID: 10655620.
      View in: PubMed   Mentions: 119     Fields:    Translation:Cells
    375. Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry. 1999 Sep 14; 38(37):11905-13. Kochendoerfer GG, Salom D, Lear JD, Wilk-Orescan R, Kent SB, DeGrado WF. PMID: 10508393.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    376. The twists and turns of beta-peptides. J Pept Res. 1999 Sep; 54(3):206-17. DeGrado WF, Schneider JP, Hamuro Y. PMID: 10517158.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    377. Tertiary templates for the design of diiron proteins. Curr Opin Struct Biol. 1999 Aug; 9(4):500-8. Summa CM, Lombardi A, Lewis M, DeGrado WF. PMID: 10449377.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    378. Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Sci. 1999 Jul; 8(7):1410-22. Patterson WR, Anderson DH, DeGrado WF, Cascio D, Eisenberg D. PMID: 10422829; PMCID: PMC2144380.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    379. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5486-91. Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF. PMID: 10318910; PMCID: PMC21886.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    380. Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds. Bioorg Med Chem Lett. 1999 Apr 05; 9(7):937-42. Rockwell AL, Rafalski M, Pitts WJ, Batt DG, Petraitis JJ, DeGrado WF, Mousa S, Jadhav PK. PMID: 10230615.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    381. The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2036-41. Hamm P, Lim M, DeGrado WF, Hochstrasser RM. PMID: 10051590; PMCID: PMC26732.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    382. Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein. J Biol Chem. 1999 Feb 26; 274(9):5474-82. Gandhi CS, Shuck K, Lear JD, Dieckmann GR, DeGrado WF, Lamb RA, Pinto LH. PMID: 10026160.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    383. Exploration of the structural features defining the conduction properties of a synthetic ion channel. Biophys J. 1999 Feb; 76(2):618-30. Dieckmann GR, Lear JD, Zhong Q, Klein ML, DeGrado WF, Sharp KA. PMID: 9929468; PMCID: PMC1300068.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    384. De novo design and structural characterization of proteins and metalloproteins. Annu Rev Biochem. 1999; 68:779-819. DeGrado WF, Summa CM, Pavone V, Nastri F, Lombardi A. PMID: 10872466.
      View in: PubMed   Mentions: 116     Fields:    Translation:Cells
    385. Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists. Bioorg Med Chem Lett. 1998 Dec 15; 8(24):3499-504. Xue CB, Roderick J, Mousa S, Olson RE, DeGrado WF. PMID: 9934460.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    386. From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin. J Mol Biol. 1998 Aug 14; 281(2):379-91. Ghirlanda G, Lear JD, Lombardi A, DeGrado WF. PMID: 9698554.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    387. The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. J Mol Biol. 1998 Jul 31; 280(5):897-912. Dieckmann GR, McRorie DK, Lear JD, Sharp KA, DeGrado WF, Pecoraro VL. PMID: 9671558.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    388. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci. 1998 Jun; 7(6):1404-14. Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. PMID: 9655345; PMCID: PMC2144029.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    389. Macrocyclic amino carboxylates as selective MMP-8 inhibitors. J Med Chem. 1998 May 21; 41(11):1749-51. Cherney RJ, Wang L, Meyer DT, Xue CB, Wasserman ZR, Hardman KD, Welch PK, Covington MB, Copeland RA, Arner EC, DeGrado WF, Decicco CP. PMID: 9599226.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    390. Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production. J Med Chem. 1998 May 21; 41(11):1745-8. Xue CB, He X, Roderick J, DeGrado WF, Cherney RJ, Hardman KD, Nelson DJ, Copeland RA, Jaffee BD, Decicco CP. PMID: 9599225.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    391. Analysis and design of three-stranded coiled coils and three-helix bundles. Fold Des. 1998; 3(2):R29-40. Schneider JP, Lombardi A, DeGrado WF. PMID: 9565750.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    392. Two models of the influenza A M2 channel domain: verification by comparison. Fold Des. 1998; 3(6):443-8. Forrest LR, DeGrado WF, Dieckmann GR, Sansom MS. PMID: 9889158.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    393. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11301-6. Pinto LH, Dieckmann GR, Gandhi CS, Papworth CG, Braman J, Shaughnessy MA, Lear JD, Lamb RA, DeGrado WF. PMID: 9326604; PMCID: PMC23448.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    394. Proteins from scratch. Science. 1997 Oct 03; 278(5335):80-1. DeGrado WF. PMID: 9340760.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    395. Modeling transmembrane helical oligomers. Curr Opin Struct Biol. 1997 Aug; 7(4):486-94. Dieckmann GR, DeGrado WF. PMID: 9266169.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    396. Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid. Bioorg Med Chem. 1997 Apr; 5(4):693-705. Xue CB, Roderick J, Jackson S, Rafalski M, Rockwell A, Mousa S, Olson RE, DeGrado WF. PMID: 9158868.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    397. Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. J Biol Chem. 1997 Mar 28; 272(13):8137-40. Bennett JS, Chan C, Vilaire G, Mousa SA, DeGrado WF. PMID: 9079626.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    398. De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles. Biochemistry. 1997 Mar 04; 36(9):2450-8. Betz SF, Liebman PA, DeGrado WF. PMID: 9054549.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    399. The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies. Protein Sci. 1997 Jan; 6(1):80-8. Ogihara NL, Weiss MS, Degrado WF, Eisenberg D. PMID: 9007979; PMCID: PMC2143514.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    400. Thermodynamic analysis of a designed three-stranded coiled coil. Biochemistry. 1996 Nov 19; 35(46):14480-5. Boice JA, Dieckmann GR, DeGrado WF, Fairman R. PMID: 8931544.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    401. Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity. Coron Artery Dis. 1996 Oct; 7(10):767-74. Mousa SA, Forsythe M, Lorelli W, Bozarth J, Xue CB, Wityak J, Sielecki TM, Olson RE, DeGrado W, Kapil R, Hussain M, Wexler R, Thoolen MJ, Reilly TM. PMID: 8970768.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    402. Expression of de novo designed alpha-helical bundles. Acta Chem Scand (Cph). 1996 Aug; 50(8):688-96. Betz SF, Bryson JW, Passador MC, Brown RJ, O'Neil KT, DeGrado WF. PMID: 8756357.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    403. Protein minimization: downsizing through mutation. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5680-1. DeGrado WF, Sosnick TR. PMID: 8650151; PMCID: PMC39119.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    404. Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils. Biochemistry. 1996 May 28; 35(21):6955-62. Betz SF, DeGrado WF. PMID: 8639647.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    405. In vitro evolution of thermodynamically stable turns. Nat Struct Biol. 1996 May; 3(5):446-51. Zhou HX, Hoess RH, DeGrado WF. PMID: 8612075.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    406. The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins. 1996 Apr; 24(4):427-32. Sosnick TR, Jackson S, Wilk RR, Englander SW, DeGrado WF. PMID: 9162943.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    407. Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist. Circulation. 1996 Feb 01; 93(3):537-43. Mousa SA, DeGrado WF, Mu DX, Kapil RP, Lucchesi BR, Reilly TM. PMID: 8565173.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    408. De novo design of heterotrimeric coiled coils. Biopolymers. 1996; 40(5):495-504. Lombardi A, Bryson JW, DeGrado WF. PMID: 9062072.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    409. Crystallization of a designed peptide from a molten globule ensemble. Fold Des. 1996; 1(1):57-64. Betz SF, Raleigh DP, DeGrado WF, Lovejoy B, Anderson D, Ogihara N, Eisenberg D. PMID: 9079364.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    410. Protein design: a hierarchic approach. Science. 1995 Nov 10; 270(5238):935-41. Bryson JW, Betz SF, Lu HS, Suich DJ, Zhou HX, O'Neil KT, DeGrado WF. PMID: 7481798.
      View in: PubMed   Mentions: 111     Fields:    Translation:Cells
    411. Native-like and structurally characterized designed alpha-helical bundles. Curr Opin Struct Biol. 1995 Aug; 5(4):457-63. Betz SF, Bryson JW, DeGrado WF. PMID: 8528761.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    412. Design of two-stranded and three-stranded coiled-coil peptides. Philos Trans R Soc Lond B Biol Sci. 1995 Apr 29; 348(1323):81-8. Betz S, Fairman R, O'Neil K, Lear J, Degrado W. PMID: 7770490.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    413. Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G. Proteins. 1995 Jan; 21(1):11-21. O'Neil KT, Hoess RH, Raleigh DP, DeGrado WF. PMID: 7716165.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    414. Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein. Protein Sci. 1994 Dec; 3(12):2419-27. Regan L, Rockwell A, Wasserman Z, DeGrado W. PMID: 7756995; PMCID: PMC2142780.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    415. Design and synthesis of simplified energy-converting proteins. Biochem Soc Trans. 1994 Aug; 22(3):689-93. Farid RS, Robertson DE, Moser CC, Pilloud D, DeGrado WF, Dutton PL. PMID: 7821665.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    416. A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4859-63. Kienker PK, DeGrado WF, Lear JD. PMID: 7515180; PMCID: PMC43888.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    417. Design and synthesis of multi-haem proteins. Nature. 1994 Mar 31; 368(6470):425-32. Robertson DE, Farid RS, Moser CC, Urbauer JL, Mulholland SE, Pidikiti R, Lear JD, Wand AJ, DeGrado WF, Dutton PL. PMID: 8133888.
      View in: PubMed   Mentions: 108     Fields:    Translation:Cells
    418. Identification of recognition sequences of adhesion molecules using phage display technology. Methods Enzymol. 1994; 245:370-86. O'Neil KT, DeGrado WF, Mousa SA, Ramachandran N, Hoess RH. PMID: 7539093.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    419. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10429-33. Fairman R, Beran-Steed RK, Anthony-Cahill SJ, Lear JD, Stafford WF, DeGrado WF, Benfield PA, Brenner SL. PMID: 8248126; PMCID: PMC47790.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    420. Peptide engineering. Catalytic molten globules. Nature. 1993 Oct 07; 365(6446):488-9. DeGrado WF. PMID: 8413599.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    421. Metal ion-dependent modulation of the dynamics of a designed protein. Science. 1993 Aug 13; 261(5123):879-85. Handel TM, Williams SA, DeGrado WF. PMID: 8346440.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    422. Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science. 1993 Feb 26; 259(5099):1288-93. Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D. PMID: 8446897.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    423. Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library. Proteins. 1992 Dec; 14(4):509-15. O'Neil KT, Hoess RH, Jackson SA, Ramachandran NS, Mousa SA, DeGrado WF. PMID: 1438188.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    424. Calmodulin binding to alpha 1-purothionin: solution binding and modeling of the complex. Proteins. 1992 Oct; 14(2):127-38. Rao U, Teeter MM, Erickson-Viitanen S, DeGrado WF. PMID: 1409564.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    425. Crystallization of proton channel peptides. Protein Sci. 1992 Aug; 1(8):1073-7. Lovejoy B, Akerfeldt KS, DeGrado WF, Eisenberg D. PMID: 1284681; PMCID: PMC2142170.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    426. Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles. Biochemistry. 1992 Jul 21; 31(28):6608-16. Chung LA, Lear JD, DeGrado WF. PMID: 1378757.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    427. X-ray grade crystals of a designed alpha-helical coiled coil. Protein Sci. 1992 Jul; 1(7):956-7. Lovejoy B, Le TC, Lüthy R, Cascio D, O'Neil KT, DeGrado WF, Eisenberg D. PMID: 1304378; PMCID: PMC2142157.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    428. Peptide models for the membrane destabilizing actions of viral fusion proteins. Biopolymers. 1992 Apr; 32(4):309-14. Epand RM, Cheetham JJ, Epand RF, Yeagle PL, Richardson CD, Rockwell A, Degrado WF. PMID: 1623124.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    429. Molecular characterization of helix-loop-helix peptides. Science. 1992 Feb 21; 255(5047):979-83. Anthony-Cahill SJ, Benfield PA, Fairman R, Wasserman ZR, Brenner SL, Stafford WF, Altenbach C, Hubbell WL, DeGrado WF. PMID: 1312255.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    430. Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesicles. Biochemistry. 1991 Oct 22; 30(42):10211-20. Rafalski M, Ortiz A, Rockwell A, van Ginkel LC, Lear JD, DeGrado WF, Wilschut J. PMID: 1931950.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    431. DNA-induced increase in the alpha-helical content of C/EBP and GCN4. Biochemistry. 1991 Sep 17; 30(37):9030-4. O'Neil KT, Shuman JD, Ampe C, DeGrado WF. PMID: 1892816.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    432. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science. 1990 Nov 02; 250(4981):646-51. O'Neil KT, DeGrado WF. PMID: 2237415.
      View in: PubMed   Mentions: 310     Fields:    Translation:Cells
    433. Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41. Biochemistry. 1990 Aug 28; 29(34):7917-22. Rafalski M, Lear JD, DeGrado WF. PMID: 2261447.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    434. Design of DNA-binding peptides based on the leucine zipper motif. Science. 1990 Aug 17; 249(4970):774-8. O'Neil KT, Hoess RH, DeGrado WF. PMID: 2389143.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    435. Crystal structure of alpha 1: implications for protein design. Science. 1990 Aug 03; 249(4968):543-6. Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D. PMID: 2382133.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    436. How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices. Trends Biochem Sci. 1990 Feb; 15(2):59-64. O'Neil KT, DeGrado WF. PMID: 2186516.
      View in: PubMed   Mentions: 211     Fields:    Translation:Cells
    437. Conformationally constrained alpha-helical peptide models for protein ion channels. Biopolymers. 1990 Jan; 29(1):205-13. DeGrado WF, Lear JD. PMID: 1691664.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    438. Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine. J Biol Chem. 1989 Aug 25; 264(24):14571-8. O'Neil KT, Erickson-Viitanen S, DeGrado WF. PMID: 2760074.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    439. Emil Thomas Kaiser 1938-1988. J Mol Recognit. 1989 Apr; 1(4):i-ii. Degrado WF, May SW. PMID: 2698723.
      View in: PubMed   Mentions:    Fields:    
    440. Protein design, a minimalist approach. Science. 1989 Feb 03; 243(4891):622-8. DeGrado WF, Wasserman ZR, Lear JD. PMID: 2464850.
      View in: PubMed   Mentions: 97     Fields:    Translation:Cells
    441. Contributions of chemistry: biotechnology and materials science. Science. 1989 Jan 06; 243(4887):102-3. Degrado WF. PMID: 17780427.
      View in: PubMed   Mentions:    Fields:    
    442. The interaction of calmodulin with fluorescent and photoreactive model peptides: evidence for a short interdomain separation. Proteins. 1989; 6(3):284-93. O'Neil KT, DeGrado WF. PMID: 2622908.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    443. Characterization of a helical protein designed from first principles. Science. 1988 Aug 19; 241(4868):976-8. Regan L, DeGrado WF. PMID: 3043666.
      View in: PubMed   Mentions: 125     Fields:    Translation:Cells
    444. Synthetic amphiphilic peptide models for protein ion channels. Science. 1988 May 27; 240(4856):1177-81. Lear JD, Wasserman ZR, DeGrado WF. PMID: 2453923.
      View in: PubMed   Mentions: 138     Fields:    
    445. Design of peptides and proteins. Adv Protein Chem. 1988; 39:51-124. Degrado WF. PMID: 3072869.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    446. Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity. Science. 1987 Jun 12; 236(4807):1454-6. O'Neil KT, Wolfe HR, Erickson-Viitanen S, DeGrado WF. PMID: 3589665.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    447. Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2. J Biol Chem. 1987 May 15; 262(14):6500-5. Lear JD, DeGrado WF. PMID: 3571268.
      View in: PubMed   Mentions: 72     Fields:    Translation:Cells
    448. The design of a four-helix bundle protein. Cold Spring Harb Symp Quant Biol. 1987; 52:521-6. DeGrado WF, Regan L, Ho SP. PMID: 3454275.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    449. Predicted calmodulin-binding sequence in the gamma subunit of phosphorylase b kinase. Proteins. 1987; 2(1):20-33. DeGrado WF, Erickson-Viitanen S, Wolfe HR, O'Neil KT. PMID: 3447166.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    450. Recognition and characterization of calmodulin-binding sequences in peptides and proteins. Methods Enzymol. 1987; 139:455-78. Erickson-Viitanen S, DeGrado WF. PMID: 3587035.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    451. The design, synthesis, and crystallization of an alpha-helical peptide. Proteins. 1986 Sep; 1(1):16-22. Eisenberg D, Wilcox W, Eshita SM, Pryciak PM, Ho SP, DeGrado WF. PMID: 3449847.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    452. p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide. J Biol Chem. 1986 Aug 15; 261(23):10695-700. Kauer JC, Erickson-Viitanen S, Wolfe HR, DeGrado WF. PMID: 3733726.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    453. Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons. J Interferon Res. 1986 Aug; 6(4):417-27. Cheng YS, Becker-Manley MF, Nguyen TD, DeGrado WF, Jonak GJ. PMID: 3095442.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    454. A predicted structure of calmodulin suggests an electrostatic basis for its function. Proc Natl Acad Sci U S A. 1985 Aug; 82(15):4954-8. O'Neil KT, DeGrado WF. PMID: 3860834; PMCID: PMC390476.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    455. In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides. Science. 1985 May 31; 228(4703):1096-9. Briggs MS, Gierasch LM, Zlotnick A, Lear JD, DeGrado WF. PMID: 3158076.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    456. The interaction of calmodulin with amphiphilic peptides. J Biol Chem. 1985 Feb 25; 260(4):2527-34. Cox JA, Comte M, Fitton JE, DeGrado WF. PMID: 2982823.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    457. The design, synthesis, and characterization of tight-binding inhibitors of calmodulin. J Cell Biochem. 1985; 29(2):83-93. DeGrado WF, Prendergast FG, Wolfe HR, Cox JA. PMID: 4066780.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    458. Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies. J Biol Chem. 1984 Oct 10; 259(19):12220-5. Chow TP, DeGrado WF, Knight E. PMID: 6480606.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    459. Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science. 1984 Aug 17; 225(4663):687-93. Persson H, Hennighausen L, Taub R, DeGrado W, Leder P. PMID: 6431612.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    460. Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine. J Biol Chem. 1984 Apr 25; 259(8):5327-32. Sigal IS, DeGrado WF, Thomas BJ, Petteway SR. PMID: 6425288.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    461. Posttranslational modification of human T-cell growth factor. Biochem Biophys Res Commun. 1983 Nov 15; 116(3):1049-55. Robb RJ, Kutny RM, Panico M, Morris H, DeGrado WF, Chowdhry V. PMID: 6606428.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    462. Sequence and structural homologies among type I and type II interferons. Nature. 1982 Nov 25; 300(5890):379-81. DeGrado WF, Wasserman ZR, Chowdhry V. PMID: 6815538.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    463. Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophys J. 1982 Jan; 37(1):329-38. DeGrado WF, Musso GF, Lieber M, Kaiser ET, Kézdy FJ. PMID: 7055625; PMCID: PMC1329147.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
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