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William DeGrado, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-476-9679
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    Collapse Biography 
    Collapse Awards and Honors
    1988Du Vigneaud Award for Young Investigators in Peptide Research
    1989Protein Society Young Investigator Award
    1992Eli Lilly Award in Biological Chemistry
    1993DuPont Merck Summit Award
    1995Fellow, American Association for the Advancement of Science
    1998Fellow, AAAS
    1999Member, National Academy of Sciences (U.S.A.)
    2003Merrifield Award, Peptide Society
    2008Ralph F. Hirschmann Award in Peptide Chemistry (American Chemical Society)
    2009Makineni Award (APS)
    The Protein Society2015The Stein and Moore Award
    Weizmann Institute2016Max Perutz Memorial Lecture
    American Chemical Society2018Cope Scholar Award
    American Chemical Society2018M. Goodman Memorial Prize
    Franklin Institute & City Council of Philadelphia2020John C. Scott Award

    Collapse Overview 
    Collapse Overview
    One research interest is in the de novo design, in which one designs proteins or drugs beginning from first principles. This approach critically tests our understanding of protein folding and function, while also laying the groundwork for the design of molecules with properties unprecedented in nature.

    Collapse Research 
    Collapse Research Activities and Funding
    Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease
    NIH/NIA RF1AG061874Sep 30, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Deciphering the relationship between structure, dynamics and function in helical bundle proteins
    NIH/NIGMS R35GM122603May 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH/NHLBI UH2HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1.
    NIH/NHLBI UH3HL123423Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Vaccines that Replicate the Neutralization-Competent Structure of the gp41 MPER
    NIH/NIAID R01AI097051Mar 1, 2012 - Feb 29, 2016
    Role: Co-Principal Investigator
    Development of drugs that target the M2 proton channel from the influenza A Virus
    NIH/NIAID U01AI074571May 15, 2008 - Oct 31, 2011
    Role: Principal Investigator
    Design and mechanistic studies of mimics of antimicrobial peptides
    NIH/NIAID R56AI074866Apr 15, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Design and mechanistic studies of mimics of antimicrobial peptides
    NIH/NIAID R01AI074866Apr 15, 2008 - Oct 31, 2011
    Role: Principal Investigator
    Proteomics to Biomimetic Polymers: Engineering Principle
    NIH/NIBIB R01EB002048Sep 24, 2002 - Aug 31, 2007
    Role: Principal Investigator
    Proteomics to Biomimetic Polymers: Engineering Principle
    NIH/NIGMS R01GM065803Sep 24, 2002 - Aug 31, 2006
    Role: Principal Investigator
    An Undulator Resource for Structural Biology
    NIH P41RR015301Jun 15, 2001 - Mar 31, 2013
    Role: Co-Investigator
    Bioorganic models for transmembrane proteins
    NIH/NIGMS R01GM060610Dec 1, 1999 - Aug 31, 2004
    Role: Principal Investigator
    Structure of M2 Proton Channel from Influenza A Virus
    NIH/NIGMS R01GM056423Aug 1, 1997 - Jul 31, 2010
    Role: Principal Investigator
    Degenerative and Dementing Diseases of Aging
    NIH/NIA P01AG002132Apr 1, 1997 - Mar 31, 2020
    Role: Co-Investigator
    PURCHASE OF ANALYTICAL ULTRACENTRIFUGE
    NIH/NCRR S10RR011854Mar 18, 1997 - Mar 17, 1998
    Role: Principal Investigator
    De Novo Design of Alpha-Helical Bundles
    NIH/NIGMS R01GM054616Aug 1, 1996 - Jun 30, 2018
    Role: Principal Investigator
    De novo design of alpha-helical bundles
    NIH/NIGMS R37GM054616Aug 1, 1996 - Oct 31, 2011
    Role: Principal Investigator
    Principles of Energy Transduction in Proteins
    NIH P01GM048130Aug 1, 1993 - Jul 31, 2010
    Role: Co-Investigator
    High Performance Computing for Biomedical Research
    NIH P41RR006009Sep 1, 1990 - Jul 31, 2013
    Role: Co-Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    ULTRAFAST OPTICAL PROCESSES LABORATORY
    NIH P41RR001348Aug 1, 1982 - May 31, 2012
    Role: Co-Investigator

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    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dual antagonists of a5ß1/ avß1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 Sep 29; 127578. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395.
      View in: PubMed   Mentions:    Fields:    
    2. Prion biology: implications for Alzheimer's disease therapeutics. Lancet Neurol. 2020 10; 19(10):802-803. Condello C, DeGrado WF, Prusiner SB. PMID: 32949533.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. J Am Chem Soc. 2020 Sep 15. Watkins LC, DeGrado WF, Voth GA. PMID: 32933245.
      View in: PubMed   Mentions:    Fields:    
    4. A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 2020 09 04; 369(6508):1227-1233. Polizzi NF, DeGrado WF. PMID: 32883865.
      View in: PubMed   Mentions:    Fields:    
    5. Robust Sequence Determinants of a-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 08 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289.
      View in: PubMed   Mentions:    Fields:    
    6. Deep mutational scanning reveals the structural basis for a-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. De novo protein design, a retrospective. Q Rev Biophys. 2020 Feb 11; 53:e3. Korendovych IV, DeGrado WF. PMID: 32041676.
      View in: PubMed   Mentions: 4     Fields:    
    8. X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry. 2020 02 04; 59(4):627-634. Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A. PMID: 31894969.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. De novo design of a homo-trimeric amantadine-binding protein. Elife. 2019 12 19; 8. Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. PMID: 31854299.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. J Biol Chem. 2019 11 29; 294(48):18232-18243. Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. PMID: 31640988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. In vitro 0N4R tau fibrils contain a monomorphic ß-sheet core enclosed by dynamically heterogeneous fuzzy coat segments. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16357-16366. Dregni AJ, Mandala VS, Wu H, Elkins MR, Wang HK, Hung I, DeGrado WF, Hong M. PMID: 31358628.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel. J Am Chem Soc. 2019 07 24; 141(29):11667-11676. Watkins LC, Liang R, Swanson JMJ, DeGrado WF, Voth GA. PMID: 31264413.
      View in: PubMed   Mentions: 5     Fields:    
    13. Modulating Integrin aIIbß3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts. Biochemistry. 2019 07 30; 58(30):3251-3259. Tan SK, Fong KP, Polizzi NF, Sternisha A, Slusky JSG, Yoon K, DeGrado WF, Bennett JS. PMID: 31264850.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case. J Am Chem Soc. 2019 07 24; 141(29):11481-11488. Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF. PMID: 31184871.
      View in: PubMed   Mentions: 3     Fields:    
    15. Unique transmembrane domain interactions differentially modulate integrin avß3 and aIIbß3 function. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12295-12300. Litvinov RI, Mravic M, Zhu H, Weisel JW, DeGrado WF, Bennett JS. PMID: 31160446.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. J Am Chem Soc. 2019 05 15; 141(19):7698-7703. Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado WF, Wang Q, Wang PG, Wang L. PMID: 31038942.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. Aß and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Sci Transl Med. 2019 05 01; 11(490). Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. PMID: 31043574.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions. Chem Commun (Camb). 2019 Apr 25; 55(35):5095-5098. Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H. PMID: 30957824.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Glutamine Side Chain 13C-18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly. J Am Chem Soc. 2019 05 08; 141(18):7320-7326. Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF. PMID: 30998340.
      View in: PubMed   Mentions:    Fields:    
    20. De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities. Acc Chem Res. 2019 05 21; 52(5):1148-1159. Lombardi A, Pirro F, Maglio O, Chino M, DeGrado WF. PMID: 30973707.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    21. Packing of apolar side chains enables accurate design of highly stable membrane proteins. Science. 2019 03 29; 363(6434):1418-1423. Mravic M, Thomaston JL, Tucker M, Solomon PE, Liu L, DeGrado WF. PMID: 30923216.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    22. SNAC-tag for sequence-specific chemical protein cleavage. Nat Methods. 2019 04; 16(4):319-322. Dang B, Mravic M, Hu H, Schmidt N, Mensa B, DeGrado WF. PMID: 30923372.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    23. Exposing the Nucleation Site in a-Helix Folding: A Joint Experimental and Simulation Study. J Phys Chem B. 2019 02 28; 123(8):1797-1807. Acharyya A, Ge Y, Wu H, DeGrado WF, Voelz VA, Gai F. PMID: 30694671.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. 4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics. Molecules. 2019 Feb 08; 24(3). Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F. PMID: 30744004.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    25. Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations. Cancer Cell. 2018 11 12; 34(5):792-806.e5. Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S. PMID: 30449325.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):11162-11167. Yang B, Wu H, Schnier PD, Liu Y, Liu J, Wang N, DeGrado WF, Wang L. PMID: 30322930.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    27. Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J Am Chem Soc. 2018 11 14; 140(45):15219-15226. Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF. PMID: 30165017.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    28. Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster. Biopolymers. 2018 Aug; 109(10):e23339. Chino M, Zhang SQ, Pirro F, Leone L, Maglio O, Lombardi A, DeGrado WF. PMID: 30203532.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    29. Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. Angew Chem Int Ed Engl. 2018 09 24; 57(39):12702-12706. Liu J, Cheng R, Wu H, Li S, Wang PG, DeGrado WF, Rozovsky S, Wang L. PMID: 30118570.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Designed peptides that assemble into cross-a amyloid-like structures. Nat Chem Biol. 2018 09; 14(9):870-875. Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. PMID: 30061717.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    32. Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus. J Am Chem Soc. 2018 06 20; 140(24):7471-7485. Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters JM, Schmidt N, Pelton JG, Gross CA, Meiler J, DeGrado WF. PMID: 29771498.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    33. Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity. ACS Nano. 2018 07 24; 12(7):6554-6562. Kang ES, Kim YT, Ko YS, Kim NH, Cho G, Huh YH, Kim JH, Nam J, Thach TT, Youn D, Kim YD, Yun WS, DeGrado WF, Kim SY, Hammond PT, Lee J, Kwon YU, Ha DH, Kim YH. PMID: 29842775.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    34. De novo designed transmembrane peptides activating the a5ß1 integrin. Protein Eng Des Sel. 2018 05 01; 31(5):181-190. Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF. PMID: 29992271.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle. Chembiochem. 2018 05 04; 19(9):902-906. Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF. PMID: 29417711.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    36. De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles. J Am Chem Soc. 2018 01 31; 140(4):1294-1304. Zhang SQ, Chino M, Liu L, Tang Y, Hu X, DeGrado WF, Lombardi A. PMID: 29249157.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    37. A long-lived Aß oligomer resistant to fibrillization. Biopolymers. 2018 Aug; 109(8):e23096. Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF. PMID: 29319162.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Structural heterogeneity and intersubject variability of Aß in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E782-E791. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB. PMID: 29311311.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    39. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 12 21; 8(1):2240. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. PMID: 29269770.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. Nat Commun. 2017 11 08; 8(1):1365. Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E. PMID: 29118336.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    41. De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10852-10857. Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva DA, Baker D, DeGrado WF. PMID: 28973862.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    42. XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13357-13362. Thomaston JL, Woldeyes RA, Nakane T, Yamashita A, Tanaka T, Koiwai K, Brewster AS, Barad BA, Chen Y, Lemmin T, Uervirojnangkoorn M, Arima T, Kobayashi J, Masuda T, Suzuki M, Sugahara M, Sauter NK, Tanaka R, Nureki O, Tono K, Joti Y, Nango E, Iwata S, Yumoto F, Fraser JS, DeGrado WF. PMID: 28835537.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    43. De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nat Chem. 2017 12; 9(12):1157-1164. Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF. PMID: 29168496.
      View in: PubMed   Mentions: 10     Fields:    
    44. Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport. Philos Trans R Soc Lond B Biol Sci. 2017 08 05; 372(1726). Joh NH, Grigoryan G, Wu Y, DeGrado WF. PMID: 28630154.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    45. Zinc-binding structure of a catalytic amyloid from solid-state NMR. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6191-6196. Lee M, Wang T, Makhlynets OV, Wu Y, Polizzi NF, Wu H, Gosavi PM, Stöhr J, Korendovych IV, DeGrado WF, Hong M. PMID: 28566494.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    46. Blue fluorescent amino acid for biological spectroscopy and microscopy. Proc Natl Acad Sci U S A. 2017 06 06; 114(23):6005-6009. Hilaire MR, Ahmed IA, Lin CW, Jo H, DeGrado WF, Gai F. PMID: 28533371.
      View in: PubMed   Mentions: 8     Fields:    
    47. Water Distribution, Dynamics, and Interactions with Alzheimer's ß-Amyloid Fibrils Investigated by Solid-State NMR. J Am Chem Soc. 2017 05 03; 139(17):6242-6252. Wang T, Jo H, DeGrado WF, Hong M. PMID: 28406028.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    48. Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy. Angew Chem Int Ed Engl. 2017 05 02; 56(19):5283-5287. Lin CW, Mensa B, Barniol-Xicota M, DeGrado WF, Gai F. PMID: 28374543.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    49. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem. 2017 09; 9(9):874-881. Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. PMID: 28837163.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    50. Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function. ACS Chem Neurosci. 2017 06 21; 8(6):1313-1326. Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL. PMID: 28278376.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases. Protein Sci. 2017 03; 26(3):414-435. Schmidt NW, Grigoryan G, DeGrado WF. PMID: 27977891.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    52. Pharmacologic Blockade of avß1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    53. An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral Res. 2017 04; 140:45-54. Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J. PMID: 28087313.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    54. Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    55. Acid activation mechanism of the influenza A M2 proton channel. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):E6955-E6964. Liang R, Swanson JMJ, Madsen JJ, Hong M, DeGrado WF, Voth GA. PMID: 27791184.
      View in: PubMed   Mentions: 14     Fields:    
    56. Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel. Phys Chem Chem Phys. 2016 Oct 19; 18(41):28939-28950. Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F. PMID: 27725984.
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    212. Computational design of peptides that target transmembrane helices. Science. 2007 Mar 30; 315(5820):1817-22. Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. PMID: 17395823.
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    213. Interactions of ADP-stimulated human platelets with PEGylated polystyrene substrates prepared by surface amidation. Colloids Surf B Biointerfaces. 2007 Aug 01; 58(2):225-30. Wang PC, Vilaire G, DeGrado WF, Bennett JS. PMID: 17499487.
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    214. The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. FEBS J. 2007 Mar; 274(6):1481-91. White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. PMID: 17489103.
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    215. Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16740-5. Fang C, Senes A, Cristian L, DeGrado WF, Hochstrasser RM. PMID: 17075037.
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    216. Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations. J Struct Biol. 2007 Mar; 157(3):444-53. Dal Peraro M, Spiegel K, Lamoureux G, De Vivo M, DeGrado WF, Klein ML. PMID: 17188512.
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    217. Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb. J Biol Chem. 2006 Dec 01; 281(48):36732-41. Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. PMID: 17032655.
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    218. E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices. J Mol Biol. 2007 Feb 16; 366(2):436-48. Senes A, Chadi DC, Law PB, Walters RF, Nanda V, Degrado WF. PMID: 17174324.
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    219. Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding. Biochemistry. 2006 Sep 12; 45(36):10981-6. Bunagan MR, Cristian L, DeGrado WF, Gai F. PMID: 16953584.
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    220. Helix-packing motifs in membrane proteins. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13658-63. Walters RF, DeGrado WF. PMID: 16954199.
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    221. The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis. Angew Chem Int Ed Engl. 2006 Jul 24; 45(30):4951-4. Wade H, Stayrook SE, Degrado WF. PMID: 16819737.
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    222. Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction. Bioorg Med Chem Lett. 2006 Jul 01; 16(13):3380-2. Yin H, Gerlach LO, Miller MW, Moore DT, Liu D, Vilaire G, Bennett JS, DeGrado WF. PMID: 16678410.
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    223. Probing Membrane Insertion Activity of Antimicrobial Polymers via Coarse-grain Molecular Dynamics. J Chem Theory Comput. 2006 May; 2(3):649-655. Lopez CF, Nielsen SO, Srinivas G, Degrado WF, Klein ML. PMID: 18985168.
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    225. Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering. Biochemistry. 2006 Apr 18; 45(15):4957-64. Litvinov RI, Vilaire G, Li W, DeGrado WF, Weisel JW, Bennett JS. PMID: 16605263.
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    226. Polar networks control oligomeric assembly in membranes. J Am Chem Soc. 2006 Apr 05; 128(13):4170-1. Tatko CD, Nanda V, Lear JD, Degrado WF. PMID: 16568959.
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    227. Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study. J Phys Chem B. 2006 Mar 02; 110(8):3517-26. Pophristic V, Vemparala S, Ivanov I, Liu Z, Klein ML, DeGrado WF. PMID: 16494407.
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    228. Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics. J Am Chem Soc. 2006 Feb 15; 128(6):1778-9. Ivanov I, Vemparala S, Pophristic V, Kuroda K, DeGrado WF, McCammon JA, Klein ML. PMID: 16464062.
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    229. Computational design of heterochiral peptides against a helical target. J Am Chem Soc. 2006 Jan 25; 128(3):809-16. Nanda V, DeGrado WF. PMID: 16417370.
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    230. Arylamide derivatives as peptidomimetic inhibitors of calmodulin. Org Lett. 2006 Jan 19; 8(2):223-5. Yin H, Frederick KK, Liu D, Wand AJ, Degrado WF. PMID: 16408880.
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    231. Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography. J Am Chem Soc. 2005 Dec 14; 127(49):17266-76. Geremia S, Di Costanzo L, Randaccio L, Engel DE, Lombardi A, Nastri F, DeGrado WF. PMID: 16332076.
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    232. Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. J Am Chem Soc. 2005 Nov 23; 127(46):16098-106. Wei PP, Skulan AJ, Wade H, DeGrado WF, Solomon EI. PMID: 16287296.
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    233. Alpha-alpha linking motifs and interhelical orientations. Proteins. 2005 Nov 01; 61(2):325-37. Engel DE, DeGrado WF. PMID: 16104016.
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    234. The design and evaluation of heparin-binding foldamers. Angew Chem Int Ed Engl. 2005 Oct 21; 44(41):6685-9. Choi S, Clements DJ, Pophristic V, Ivanov I, Vemparala S, Bennett JS, Klein ML, Winkler JD, DeGrado WF. PMID: 16094685.
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    235. An atomic environment potential for use in protein structure prediction. J Mol Biol. 2005 Sep 30; 352(4):986-1001. Summa CM, Levitt M, Degrado WF. PMID: 16126228.
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    236. Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops. J Biol Inorg Chem. 2005 Aug; 10(5):539-49. Maglio O, Nastri F, Calhoun JR, Lahr S, Wade H, Pavone V, DeGrado WF, Lombardi A. PMID: 16091937.
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    237. T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. Biophys J. 2005 Dec; 89(6):4180-7. Wang T, Lau WL, DeGrado WF, Gai F. PMID: 16150962.
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    238. Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion. Biomaterials. 2005 Aug; 26(23):4757-66. Willcox PJ, Reinhart-King CA, Lahr SJ, DeGrado WF, Hammer DA. PMID: 15763255.
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    239. Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol. 2005 Jun 28; 5:11. Kovalenko OV, Metcalf DG, DeGrado WF, Hemler ME. PMID: 15985154.
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    240. Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins. Proteins. 2005 May 15; 59(3):496-509. Adamian L, Nanda V, DeGrado WF, Liang J. PMID: 15789404.
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    241. Automated use of mutagenesis data in structure prediction. Proteins. 2005 May 15; 59(3):454-66. Nanda V, DeGrado WF. PMID: 15768404.
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    242. X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils. J Mol Biol. 2005 May 06; 348(3):777-87. Slovic AM, Stayrook SE, North B, Degrado WF. PMID: 15826670.
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    243. De novo design of a redox-active minimal rubredoxin mimic. J Am Chem Soc. 2005 Apr 27; 127(16):5804-5. Nanda V, Rosenblatt MM, Osyczka A, Kono H, Getahun Z, Dutton PL, Saven JG, Degrado WF. PMID: 15839675.
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    244. Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability. J Mol Biol. 2005 May 20; 348(5):1225-33. Cristian L, Nanda V, Lear JD, DeGrado WF. PMID: 15854657.
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    245. Amphiphilic polymethacrylate derivatives as antimicrobial agents. J Am Chem Soc. 2005 Mar 30; 127(12):4128-9. Kuroda K, DeGrado WF. PMID: 15783168.
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    246. The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Sci. 2005 Apr; 14(4):856-61. Duong-Ly KC, Nanda V, Degrado WF, Howard KP. PMID: 15741338.
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    247. De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban. J Pept Res. 2005 Mar; 65(3):312-21. Slovic AM, Lear JD, DeGrado WF. PMID: 15787961.
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    248. Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Sci. 2005 Apr; 14(4):1019-24. Howard KP, Liu W, Crocker E, Nanda V, Lear J, Degrado WF, Smith SO. PMID: 15741331.
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    249. Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. J Am Chem Soc. 2005 Feb 09; 127(5):1346-7. Cochran FV, Wu SP, Wang W, Nanda V, Saven JG, Therien MJ, DeGrado WF. PMID: 15686346.
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    250. A push-pull mechanism for regulating integrin function. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1424-9. Li W, Metcalf DG, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear JD, Degrado WF, Bennett JS. PMID: 15671157.
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    251. Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. J Mol Biol. 2005 Mar 18; 347(1):169-79. Stouffer AL, Nanda V, Lear JD, DeGrado WF. PMID: 15733926.
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    252. Analysis and design of turns in alpha-helical hairpins. J Mol Biol. 2005 Mar 11; 346(5):1441-54. Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF. PMID: 15713492.
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    253. Artificial diiron proteins: from structure to function. Biopolymers. 2005; 80(2-3):264-78. Calhoun JR, Nastri F, Maglio O, Pavone V, Lombardi A, DeGrado WF. PMID: 15700297.
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    254. Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide. FEBS Lett. 2004 Dec 03; 578(1-2):140-4. Ghirlanda G, Hilcove SA, Pidikiti R, Johansson JS, Lear JD, Degrado WF, Eckenhoff RG. PMID: 15581631.
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    255. Simulated evolution of emergent chiral structures in polyalanine. J Am Chem Soc. 2004 Nov 10; 126(44):14459-67. Nanda V, Degrado WF. PMID: 15521766.
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    256. Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers. Chemistry. 2004 Oct 11; 10(20):5008-16. Doerksen RJ, Chen B, Liu D, Tew GN, Degrado WF, Klein ML. PMID: 15372664.
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    257. Length Dependent Helix-Coil Transition Kinetics of Nine Alanine-Based Peptides. J Phys Chem B. 2004 Sep 30; 108(39). Wang T, Zhu Y, Getahun Z, Du D, Huang CY, Degrado WF, Gai F. PMID: 24307864.
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    258. Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophys J. 2004 Nov; 87(5):3421-9. Lear JD, Stouffer AL, Gratkowski H, Nanda V, Degrado WF. PMID: 15315956.
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    259. De novo design of catalytic proteins. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11566-70. Kaplan J, DeGrado WF. PMID: 15292507.
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    260. Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 Aug; 14(4):465-79. Senes A, Engel DE, DeGrado WF. PMID: 15313242.
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    261. De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1. J Am Chem Soc. 2004 Jul 07; 126(26):8141-7. Ghirlanda G, Osyczka A, Liu W, Antolovich M, Smith KM, Dutton PL, Wand AJ, DeGrado WF. PMID: 15225055.
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    262. Structural basis for integrin alphaIIbbeta3 clustering. Biochem Soc Trans. 2004 Jun; 32(Pt3):412-5. Li R, Bennett JS, Degrado WF. PMID: 15157149.
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    263. A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. J Am Chem Soc. 2004 Apr 28; 126(16):5078-9. Tucker MJ, Getahun Z, Nanda V, DeGrado WF, Gai F. PMID: 15099085.
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    264. Amino acid propensities are position-dependent throughout the length of alpha-helices. J Mol Biol. 2004 Apr 09; 337(5):1195-205. Engel DE, DeGrado WF. PMID: 15046987.
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    265. Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem. 2004 Jun 18; 279(25):26666-73. Li R, Gorelik R, Nanda V, Law PB, Lear JD, DeGrado WF, Bennett JS. PMID: 15067009.
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    266. Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl. 2004 Feb 20; 43(9):1158-62. Liu D, Choi S, Chen B, Doerksen RJ, Clements DJ, Winkler JD, Klein ML, DeGrado WF. PMID: 14983462.
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    267. Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1828-33. Slovic AM, Kono H, Lear JD, Saven JG, DeGrado WF. PMID: 14766985.
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    268. Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophys J. 2004 Jan; 86(1 Pt 1):272-84. Lau WL, Ege DS, Lear JD, Hammer DA, DeGrado WF. PMID: 14695269.
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    269. Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol. 2003 Dec 12; 334(5):1101-15. Calhoun JR, Kono H, Lahr S, Wang W, DeGrado WF, Saven JG. PMID: 14643669.
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    270. Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15486-91. Zhu Y, Alonso DO, Maki K, Huang CY, Lahr SJ, Daggett V, Roder H, DeGrado WF, Gai F. PMID: 14671331.
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    271. Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14772-7. Cristian L, Lear JD, DeGrado WF. PMID: 14657351.
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    272. De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. J Mol Biol. 2003 Nov 14; 334(1):1-12. Signarvic RS, DeGrado WF. PMID: 14596795.
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    274. Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry. 2003 Jun 03; 42(21):6400-7. Lear JD, Gratkowski H, Adamian L, Liang J, DeGrado WF. PMID: 12767221.
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    275. Computational biology: Biosensor design. Nature. 2003 May 08; 423(6936):132-3. DeGrado WF. PMID: 12736670.
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    276. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science. 2003 May 02; 300(5620):795-8. Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, Weisel JW, Lear JD, DeGrado WF, Bennett JS. PMID: 12730600.
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    279. The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci. 2003 Mar; 12(3):520-31. Walsh ST, Cheng RP, Wright WW, Alonso DO, Daggett V, Vanderkooi JM, DeGrado WF. PMID: 12592022.
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    280. Computational design of a water-soluble analog of phospholamban. Protein Sci. 2003 Feb; 12(2):337-48. Slovic AM, Summa CM, Lear JD, DeGrado WF. PMID: 12538897.
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    281. Sliding helix and change of coordination geometry in a model di-MnII protein. Angew Chem Int Ed Engl. 2003 Jan 27; 42(4):417-20. DeGrado WF, Di Costanzo L, Geremia S, Lombardi A, Pavone V, Randaccio L. PMID: 12569505.
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    282. Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor. J Am Chem Soc. 2003 Jan 15; 125(2):560-9. Papoian GA, DeGrado WF, Klein ML. PMID: 12517172.
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    283. Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc. 2003 Jan 15; 125(2):405-11. Getahun Z, Huang CY, Wang T, De León B, DeGrado WF, Gai F. PMID: 12517152.
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    284. Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng. 2003 Jan; 16(1):65-72. Li R, Hoess RH, Bennett JS, DeGrado WF. PMID: 12646694.
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    285. Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry. 2002 Dec 31; 41(52):15618-24. Li R, Babu CR, Valentine K, Lear JD, Wand AJ, Bennett JS, DeGrado WF. PMID: 12501190.
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    286. Light-induced helix formation. J Am Chem Soc. 2002 Oct 30; 124(43):12674-5. Huang CY, He S, DeGrado WF, McCafferty DG, Gai F. PMID: 12392410.
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    287. Long-range interactions stabilize the fold of a non-natural oligomer. J Am Chem Soc. 2002 Oct 02; 124(39):11564-5. Cheng RP, DeGrado WF. PMID: 12296699.
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    291. A hierarchic approach to the design of hexameric helical barrels. J Mol Biol. 2002 May 24; 319(1):243-53. Ghirlanda G, Lear JD, Ogihara NL, Eisenberg D, DeGrado WF. PMID: 12051949.
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    292. De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5110-4. Tew GN, Liu D, Chen B, Doerksen RJ, Kaplan J, Carroll PJ, Klein ML, DeGrado WF. PMID: 11959961.
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    294. Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2788-93. Huang CY, Getahun Z, Zhu Y, Klemke JW, DeGrado WF, Gai F. PMID: 11867741.
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    295. Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. J Am Chem Soc. 2001 Dec 26; 123(51):12749-57. Di Costanzo L, Wade H, Geremia S, Randaccio L, Pavone V, DeGrado WF, Lombardi A. PMID: 11749531.
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    296. Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn. J Am Chem Soc. 2001 Dec 19; 123(50):12710-1. Cheng RP, Suich DJ, Cheng H, Roder H, DeGrado WF. PMID: 11741449.
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    297. Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides. J Am Chem Soc. 2001 Dec 05; 123(48):12111-2. Huang CY, Getahun Z, Wang T, DeGrado WF, Gai F. PMID: 11724630.
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    298. Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12462-7. Li R, Babu CR, Lear JD, Wand AJ, Bennett JS, DeGrado WF. PMID: 11606749.
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    299. Introduction: protein design. Chem Rev. 2001 Oct 10; 101(10):3025-6. DeGrado WF. PMID: 11749399.
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    300. beta-Peptides: from structure to function. Chem Rev. 2001 Oct; 101(10):3219-32. Cheng RP, Gellman SH, DeGrado WF. PMID: 11710070.
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    301. Temperature-dependent helix-coil transition of an alanine based peptide. J Am Chem Soc. 2001 Sep 26; 123(38):9235-8. Huang CY, Klemke JW, Getahun Z, DeGrado WF, Gai F. PMID: 11562202.
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    302. D(n)-symmetrical tertiary templates for the design of tubular proteins. J Mol Biol. 2001 Aug 31; 311(5):1081-90. North B, Summa CM, Ghirlanda G, DeGrado WF. PMID: 11531341.
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    303. Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. Biochemistry. 2001 Aug 14; 40(32):9560-9. Walsh ST, Lee AL, DeGrado WF, Wand AJ. PMID: 11583155.
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    304. De novo design, synthesis, and characterization of antimicrobial beta-peptides. J Am Chem Soc. 2001 Aug 08; 123(31):7553-9. Liu D, DeGrado WF. PMID: 11480975.
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    305. De novo design, synthesis and characterization of membrane-active peptides. Biochem Soc Trans. 2001 Aug; 29(Pt 4):559-64. Lear JD, Gratkowski H, DeGrado WF. PMID: 11498028.
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    306. De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions. J Am Chem Soc. 2001 May 30; 123(21):5162-3. Cheng RP, DeGrado WF. PMID: 11457373.
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    307. Proton and metal ion-dependent assembly of a model diiron protein. Protein Sci. 2001 May; 10(5):958-69. Pasternak A, Kaplan J, Lear JD, Degrado WF. PMID: 11316876.
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    308. Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hathaway for performing matrix-assisted laser desorption/ionization analyses. Angew Chem Int Ed Engl. 2001 Apr 17; 40(8):1494-1496. Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA. PMID: 11317312.
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    310. Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. Biochemistry. 2001 Mar 06; 40(9):2790-6. Tang Y, Ghirlanda G, Vaidehi N, Kua J, Mainz DT, Goddard III WA, DeGrado WF, Tirrell DA. PMID: 11258889.
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    311. Design of three-dimensional domain-swapped dimers and fibrous oligomers. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1404-9. Ogihara NL, Ghirlanda G, Bryson JW, Gingery M, DeGrado WF, Eisenberg D. PMID: 11171963.
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    312. Polar side chains drive the association of model transmembrane peptides. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):880-5. Gratkowski H, Lear JD, DeGrado WF. PMID: 11158564.
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    313. Hydrophobic core malleability of a de novo designed three-helix bundle protein. J Mol Biol. 2001 Jan 12; 305(2):361-73. Walsh ST, Sukharev VI, Betz SF, Vekshin NL, DeGrado WF. PMID: 11124911.
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    314. Evolution of binding affinity in a WW domain probed by phage display. Protein Sci. 2000 Dec; 9(12):2366-76. Dalby PA, Hoess RH, DeGrado WF. PMID: 11206058.
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    315. pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry. 2000 Nov 21; 39(46):14160-70. Salom D, Hill BR, Lear JD, DeGrado WF. PMID: 11087364.
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    316. Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13021-6. Talaga DS, Lau WL, Roder H, Tang J, Jia Y, DeGrado WF, Hochstrasser RM. PMID: 11087856.
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    317. Structural consequences of an amino acid deletion in the B1 domain of protein G. Proteins. 2000 Nov 15; 41(3):323-33. O'Neil KT, Bach AC, DeGrado WF. PMID: 11025544.
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    318. De novo design of helical bundles as models for understanding protein folding and function. Acc Chem Res. 2000 Nov; 33(11):745-54. Hill RB, Raleigh DP, Lombardi A, DeGrado WF. PMID: 11087311.
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    319. Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity. Bioorg Med Chem. 2000 Sep; 8(9):2229-41. Suich DJ, Mousa SA, Singh G, Liapakis G, Reisine T, DeGrado WF. PMID: 11026536.
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    320. The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin. J Biol Chem. 2000 Jun 16; 275(24):18337-43. Helluin O, Chan C, Vilaire G, Mousa S, DeGrado WF, Bennett JS. PMID: 10751402.
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    321. Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6298-305. Lombardi A, Summa CM, Geremia S, Randaccio L, Pavone V, DeGrado WF. PMID: 10841536.
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    322. A polar, solvent-exposed residue can be essential for native protein structure. Structure. 2000 May 15; 8(5):471-9. Hill RB, DeGrado WF. PMID: 10801493.
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    323. Asparagine-mediated self-association of a model transmembrane helix. Nat Struct Biol. 2000 Feb; 7(2):161-6. Choma C, Gratkowski H, Lear JD, DeGrado WF. PMID: 10655620.
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    324. Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry. 1999 Sep 14; 38(37):11905-13. Kochendoerfer GG, Salom D, Lear JD, Wilk-Orescan R, Kent SB, DeGrado WF. PMID: 10508393.
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    325. The twists and turns of beta-peptides. J Pept Res. 1999 Sep; 54(3):206-17. DeGrado WF, Schneider JP, Hamuro Y. PMID: 10517158.
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    326. Tertiary templates for the design of diiron proteins. Curr Opin Struct Biol. 1999 Aug; 9(4):500-8. Summa CM, Lombardi A, Lewis M, DeGrado WF. PMID: 10449377.
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    327. Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Sci. 1999 Jul; 8(7):1410-22. Patterson WR, Anderson DH, DeGrado WF, Cascio D, Eisenberg D. PMID: 10422829.
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    328. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5486-91. Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF. PMID: 10318910.
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    329. Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds. Bioorg Med Chem Lett. 1999 Apr 05; 9(7):937-42. Rockwell AL, Rafalski M, Pitts WJ, Batt DG, Petraitis JJ, DeGrado WF, Mousa S, Jadhav PK. PMID: 10230615.
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    330. The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2036-41. Hamm P, Lim M, DeGrado WF, Hochstrasser RM. PMID: 10051590.
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    331. Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein. J Biol Chem. 1999 Feb 26; 274(9):5474-82. Gandhi CS, Shuck K, Lear JD, Dieckmann GR, DeGrado WF, Lamb RA, Pinto LH. PMID: 10026160.
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    332. Exploration of the structural features defining the conduction properties of a synthetic ion channel. Biophys J. 1999 Feb; 76(2):618-30. Dieckmann GR, Lear JD, Zhong Q, Klein ML, DeGrado WF, Sharp KA. PMID: 9929468.
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    333. De novo design and structural characterization of proteins and metalloproteins. Annu Rev Biochem. 1999; 68:779-819. DeGrado WF, Summa CM, Pavone V, Nastri F, Lombardi A. PMID: 10872466.
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    334. Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists. Bioorg Med Chem Lett. 1998 Dec 15; 8(24):3499-504. Xue CB, Roderick J, Mousa S, Olson RE, DeGrado WF. PMID: 9934460.
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    335. From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin. J Mol Biol. 1998 Aug 14; 281(2):379-91. Ghirlanda G, Lear JD, Lombardi A, DeGrado WF. PMID: 9698554.
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    336. The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. J Mol Biol. 1998 Jul 31; 280(5):897-912. Dieckmann GR, McRorie DK, Lear JD, Sharp KA, DeGrado WF, Pecoraro VL. PMID: 9671558.
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    337. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci. 1998 Jun; 7(6):1404-14. Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. PMID: 9655345.
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    338. Macrocyclic amino carboxylates as selective MMP-8 inhibitors. J Med Chem. 1998 May 21; 41(11):1749-51. Cherney RJ, Wang L, Meyer DT, Xue CB, Wasserman ZR, Hardman KD, Welch PK, Covington MB, Copeland RA, Arner EC, DeGrado WF, Decicco CP. PMID: 9599226.
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    339. Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production. J Med Chem. 1998 May 21; 41(11):1745-8. Xue CB, He X, Roderick J, DeGrado WF, Cherney RJ, Hardman KD, Nelson DJ, Copeland RA, Jaffee BD, Decicco CP. PMID: 9599225.
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    340. Analysis and design of three-stranded coiled coils and three-helix bundles. Fold Des. 1998; 3(2):R29-40. Schneider JP, Lombardi A, DeGrado WF. PMID: 9565750.
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    341. Two models of the influenza A M2 channel domain: verification by comparison. Fold Des. 1998; 3(6):443-8. Forrest LR, DeGrado WF, Dieckmann GR, Sansom MS. PMID: 9889158.
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    342. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11301-6. Pinto LH, Dieckmann GR, Gandhi CS, Papworth CG, Braman J, Shaughnessy MA, Lear JD, Lamb RA, DeGrado WF. PMID: 9326604.
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    343. Proteins from scratch. Science. 1997 Oct 03; 278(5335):80-1. DeGrado WF. PMID: 9340760.
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    344. Modeling transmembrane helical oligomers. Curr Opin Struct Biol. 1997 Aug; 7(4):486-94. Dieckmann GR, DeGrado WF. PMID: 9266169.
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    345. Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid. Bioorg Med Chem. 1997 Apr; 5(4):693-705. Xue CB, Roderick J, Jackson S, Rafalski M, Rockwell A, Mousa S, Olson RE, DeGrado WF. PMID: 9158868.
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    346. Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. J Biol Chem. 1997 Mar 28; 272(13):8137-40. Bennett JS, Chan C, Vilaire G, Mousa SA, DeGrado WF. PMID: 9079626.
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    347. De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles. Biochemistry. 1997 Mar 04; 36(9):2450-8. Betz SF, Liebman PA, DeGrado WF. PMID: 9054549.
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    348. The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies. Protein Sci. 1997 Jan; 6(1):80-8. Ogihara NL, Weiss MS, Degrado WF, Eisenberg D. PMID: 9007979.
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    349. Thermodynamic analysis of a designed three-stranded coiled coil. Biochemistry. 1996 Nov 19; 35(46):14480-5. Boice JA, Dieckmann GR, DeGrado WF, Fairman R. PMID: 8931544.
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    350. Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity. Coron Artery Dis. 1996 Oct; 7(10):767-74. Mousa SA, Forsythe M, Lorelli W, Bozarth J, Xue CB, Wityak J, Sielecki TM, Olson RE, DeGrado W, Kapil R, Hussain M, Wexler R, Thoolen MJ, Reilly TM. PMID: 8970768.
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    351. Expression of de novo designed alpha-helical bundles. Acta Chem Scand. 1996 Aug; 50(8):688-96. Betz SF, Bryson JW, Passador MC, Brown RJ, O'Neil KT, DeGrado WF. PMID: 8756357.
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    352. Protein minimization: downsizing through mutation. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5680-1. DeGrado WF, Sosnick TR. PMID: 8650151.
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    353. Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils. Biochemistry. 1996 May 28; 35(21):6955-62. Betz SF, DeGrado WF. PMID: 8639647.
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    354. In vitro evolution of thermodynamically stable turns. Nat Struct Biol. 1996 May; 3(5):446-51. Zhou HX, Hoess RH, DeGrado WF. PMID: 8612075.
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    355. The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins. 1996 Apr; 24(4):427-32. Sosnick TR, Jackson S, Wilk RR, Englander SW, DeGrado WF. PMID: 9162943.
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    356. Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist. Circulation. 1996 Feb 01; 93(3):537-43. Mousa SA, DeGrado WF, Mu DX, Kapil RP, Lucchesi BR, Reilly TM. PMID: 8565173.
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    357. De novo design of heterotrimeric coiled coils. Biopolymers. 1996; 40(5):495-504. Lombardi A, Bryson JW, DeGrado WF. PMID: 9062072.
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    358. Crystallization of a designed peptide from a molten globule ensemble. Fold Des. 1996; 1(1):57-64. Betz SF, Raleigh DP, DeGrado WF, Lovejoy B, Anderson D, Ogihara N, Eisenberg D. PMID: 9079364.
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    359. Protein design: a hierarchic approach. Science. 1995 Nov 10; 270(5238):935-41. Bryson JW, Betz SF, Lu HS, Suich DJ, Zhou HX, O'Neil KT, DeGrado WF. PMID: 7481798.
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    360. Native-like and structurally characterized designed alpha-helical bundles. Curr Opin Struct Biol. 1995 Aug; 5(4):457-63. Betz SF, Bryson JW, DeGrado WF. PMID: 8528761.
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    361. Design of two-stranded and three-stranded coiled-coil peptides. Philos Trans R Soc Lond B Biol Sci. 1995 Apr 29; 348(1323):81-8. Betz S, Fairman R, O'Neil K, Lear J, Degrado W. PMID: 7770490.
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    362. Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G. Proteins. 1995 Jan; 21(1):11-21. O'Neil KT, Hoess RH, Raleigh DP, DeGrado WF. PMID: 7716165.
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    365. A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4859-63. Kienker PK, DeGrado WF, Lear JD. PMID: 7515180.
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    366. Design and synthesis of multi-haem proteins. Nature. 1994 Mar 31; 368(6470):425-32. Robertson DE, Farid RS, Moser CC, Urbauer JL, Mulholland SE, Pidikiti R, Lear JD, Wand AJ, DeGrado WF, Dutton PL. PMID: 8133888.
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    367. Identification of recognition sequences of adhesion molecules using phage display technology. Methods Enzymol. 1994; 245:370-86. O'Neil KT, DeGrado WF, Mousa SA, Ramachandran N, Hoess RH. PMID: 7539093.
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    368. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10429-33. Fairman R, Beran-Steed RK, Anthony-Cahill SJ, Lear JD, Stafford WF, DeGrado WF, Benfield PA, Brenner SL. PMID: 8248126.
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    369. Peptide engineering. Catalytic molten globules. Nature. 1993 Oct 07; 365(6446):488-9. DeGrado WF. PMID: 8413599.
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    373. Calmodulin binding to alpha 1-purothionin: solution binding and modeling of the complex. Proteins. 1992 Oct; 14(2):127-38. Rao U, Teeter MM, Erickson-Viitanen S, DeGrado WF. PMID: 1409564.
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    384. Crystal structure of alpha 1: implications for protein design. Science. 1990 Aug 03; 249(4968):543-6. Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D. PMID: 2382133.
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    385. How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices. Trends Biochem Sci. 1990 Feb; 15(2):59-64. O'Neil KT, DeGrado WF. PMID: 2186516.
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    386. Conformationally constrained alpha-helical peptide models for protein ion channels. Biopolymers. 1990 Jan; 29(1):205-13. DeGrado WF, Lear JD. PMID: 1691664.
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    387. Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine. J Biol Chem. 1989 Aug 25; 264(24):14571-8. O'Neil KT, Erickson-Viitanen S, DeGrado WF. PMID: 2760074.
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    388. Emil Thomas Kaiser 1938-1988. J Mol Recognit. 1989 Apr; 1(4):i-ii. Degrado WF, May SW. PMID: 2698723.
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    389. Protein design, a minimalist approach. Science. 1989 Feb 03; 243(4891):622-8. DeGrado WF, Wasserman ZR, Lear JD. PMID: 2464850.
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    390. Contributions of chemistry: biotechnology and materials science. Science. 1989 Jan 06; 243(4887):102-3. Degrado WF. PMID: 17780427.
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    391. The interaction of calmodulin with fluorescent and photoreactive model peptides: evidence for a short interdomain separation. Proteins. 1989; 6(3):284-93. O'Neil KT, DeGrado WF. PMID: 2622908.
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    392. Characterization of a helical protein designed from first principles. Science. 1988 Aug 19; 241(4868):976-8. Regan L, DeGrado WF. PMID: 3043666.
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    393. Synthetic amphiphilic peptide models for protein ion channels. Science. 1988 May 27; 240(4856):1177-81. Lear JD, Wasserman ZR, DeGrado WF. PMID: 2453923.
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    394. Design of peptides and proteins. Adv Protein Chem. 1988; 39:51-124. Degrado WF. PMID: 3072869.
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    395. Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity. Science. 1987 Jun 12; 236(4807):1454-6. O'Neil KT, Wolfe HR, Erickson-Viitanen S, DeGrado WF. PMID: 3589665.
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    396. Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2. J Biol Chem. 1987 May 15; 262(14):6500-5. Lear JD, DeGrado WF. PMID: 3571268.
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    397. Predicted calmodulin-binding sequence in the gamma subunit of phosphorylase b kinase. Proteins. 1987; 2(1):20-33. DeGrado WF, Erickson-Viitanen S, Wolfe HR, O'Neil KT. PMID: 3447166.
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    398. The design of a four-helix bundle protein. Cold Spring Harb Symp Quant Biol. 1987; 52:521-6. DeGrado WF, Regan L, Ho SP. PMID: 3454275.
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    399. Recognition and characterization of calmodulin-binding sequences in peptides and proteins. Methods Enzymol. 1987; 139:455-78. Erickson-Viitanen S, DeGrado WF. PMID: 3587035.
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    400. The design, synthesis, and crystallization of an alpha-helical peptide. Proteins. 1986 Sep; 1(1):16-22. Eisenberg D, Wilcox W, Eshita SM, Pryciak PM, Ho SP, DeGrado WF. PMID: 3449847.
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    401. p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide. J Biol Chem. 1986 Aug 15; 261(23):10695-700. Kauer JC, Erickson-Viitanen S, Wolfe HR, DeGrado WF. PMID: 3733726.
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    402. Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons. J Interferon Res. 1986 Aug; 6(4):417-27. Cheng YS, Becker-Manley MF, Nguyen TD, DeGrado WF, Jonak GJ. PMID: 3095442.
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    403. A predicted structure of calmodulin suggests an electrostatic basis for its function. Proc Natl Acad Sci U S A. 1985 Aug; 82(15):4954-8. O'Neil KT, DeGrado WF. PMID: 3860834.
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    404. In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides. Science. 1985 May 31; 228(4703):1096-9. Briggs MS, Gierasch LM, Zlotnick A, Lear JD, DeGrado WF. PMID: 3158076.
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    405. The interaction of calmodulin with amphiphilic peptides. J Biol Chem. 1985 Feb 25; 260(4):2527-34. Cox JA, Comte M, Fitton JE, DeGrado WF. PMID: 2982823.
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    406. The design, synthesis, and characterization of tight-binding inhibitors of calmodulin. J Cell Biochem. 1985; 29(2):83-93. DeGrado WF, Prendergast FG, Wolfe HR, Cox JA. PMID: 4066780.
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    407. Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies. J Biol Chem. 1984 Oct 10; 259(19):12220-5. Chow TP, DeGrado WF, Knight E. PMID: 6480606.
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    408. Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science. 1984 Aug 17; 225(4663):687-93. Persson H, Hennighausen L, Taub R, DeGrado W, Leder P. PMID: 6431612.
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    409. Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine. J Biol Chem. 1984 Apr 25; 259(8):5327-32. Sigal IS, DeGrado WF, Thomas BJ, Petteway SR. PMID: 6425288.
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    410. Posttranslational modification of human T-cell growth factor. Biochem Biophys Res Commun. 1983 Nov 15; 116(3):1049-55. Robb RJ, Kutny RM, Panico M, Morris H, DeGrado WF, Chowdhry V. PMID: 6606428.
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    411. Sequence and structural homologies among type I and type II interferons. Nature. 1982 Nov 25; 300(5890):379-81. DeGrado WF, Wasserman ZR, Chowdhry V. PMID: 6815538.
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    412. Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophys J. 1982 Jan; 37(1):329-38. DeGrado WF, Musso GF, Lieber M, Kaiser ET, Kézdy FJ. PMID: 7055625.
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