Marc Simon, MD, MS

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-502-8584
ORCID ORCID Icon0000-0003-3080-3675 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, PhiladelphiaBSE05/1994Bioengineering
    University of Maryland, BaltimoreMD05/1998Medicine
    University of Pittsburgh, PittsburghMS05/2007Bioengineering
    University of Colorado School of Medicine and Affiliated Hospitals, DenverResident06/2001Internal Medicine
    UPMC, PittsburghFellow06/2004Cardiovascular Disease
    UPMC, PittsburghFellow06/2005Advanced Heart Failure and Transplantation
    Collapse Awards and Honors
    AHA2010  - 2012Claude R. Joyner, M.D. Research Award for Young Medical Researchers
    PFIZER2010  - 20112010 ASPIRE Young Investigator Research Award

    Collapse Overview 
    Collapse Overview
    CLINICAL INTERESTS: Dr. Simon is director of Pulmonary Vascular Disease and the Pulmonary Hypertension Comprehensive Care Center. He has expertise as a cardiologist specializing in pulmonary hypertension, advanced heart failure, and heart transplantation.

    RESEARCH INTERESTS: Dr. Simon’s research primary research focus involves developing new therapies for pulmonary hypertension and better understanding right-sided heart failure in pulmonary hypertension (PH). Notably, right-sided heart failure and PH are associated with poor outcomes and in particular have been noted to occur in another type of heart failure, called heart failure with preserved ejection fraction or HFpEF, in which the heart seems to function normally but causes difficulty breathing due to a stiffening of the heart and blood vessels.

    Collapse Research 
    Collapse Research Activities and Funding
    Operationalizing Patient-Reported Outcome Measurement with Electronic Health Records in Patients with Heart Failure
    Patient-Centered Outcomes Research Institute ASP-1502-27079May 1, 2019 - Jun 30, 2020
    Role: Co-Investigator
    Description: The goal of this grant is to operationalize the use of Patient-Reported Outcome Measurement with Electronic Health Records. A validated Patient-Reported Outcome Measurement will be administered in the heart failure clinics, and integrated with the Electronic Health Record for clinical use.
    Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction
    NIH R01AG058659May 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Molecular Drivers of Vascular Stiffness and Metabolic Dysfunction in HIV-Induced Pulmonary Arterial Hypertension
    NIH R01HL138437Jul 1, 2017 - Jun 30, 2021
    Role: Co-Investigator
    LED-enabled Real- time BNP Detection based on flexible substrate
    National Science Foundation NSF CBET 1706620Jul 1, 2017 - Jun 30, 2020
    Role: Co-Investigator
    Description: The goal of this project is to develop a LED-enabled Real- time BNP Detection based on flexible substrate.
    Ventricular Morphological and Mechanical Response to LCZ696
    Novartis LCZ696BUSNC0TJan 1, 2017 - Aug 30, 2019
    Role: PI
    Description: This is a preclinical study of the effect of LCZ696 on right ventricular remodeling and tissue biomechanics in a pulmonary hypertension model.
    Nitrite benefits to mediate fatigability in older HFpEF patients
    NIH R56AG051637Aug 15, 2016 - Dec 31, 2018
    Role: Co-Investigator
    University of Pittsburgh Clinical and Translational Science Institute
    NIH UL1TR001857Jul 12, 2016 - May 31, 2021
    Role: Medical Director, Montefiore Clinical Translational Research Center; Core Director, Recruitment Inno
    Description: Medical Director, Montefiore Clinical Translational Research Center 2016-2020; Core Director, Recruitment Innovation Unit 2019-2020
    The Role of EBP50 in Right Heart Hypertrophy and Dysfunction in Pulmonary Hypertension-induced Pressure Overload
    University of Pittsburgh Vascular Medicine Institute (VMI) & UPMC Heart & Vascular Institute (HVI) VMI-HVI InnovatorMar 1, 2015 - Jun 30, 2016
    Role: Co-PI
    Description: This project studies the relationship between the scaffolding protein EBP50 and tissue biomechanics in PH.
    Immune dysfunction and pulmonary hypertension in primate model of HIV infection
    NIH R56HL126525Sep 3, 2014 - Aug 31, 2017
    Role: Co-Investigator
    Longitudinal evaluation of HIV-associated lung disease phenotypes
    NIH R01HL125049Aug 15, 2014 - Jun 30, 2019
    Role: Co-Investigator
    Mitochondrial function in RV failure
    University of Pittsburgh Vascular Medicine Institute (VMI) & UPMC Heart & Vascular Institute (HVI) VMI-HVI InnovatorJul 1, 2014 - Jun 30, 2015
    Role: Co-PI
    Description: This project studies the relationship between RV mitochondrial function and tissue biomechanics.
    Blended Collaborative Care for Heart Failure and Co-Morbid Depression
    NIH R01HL114016Aug 1, 2013 - Jul 31, 2021
    Role: Co-Investigator
    National Biological Sample and Data Repository for PAH
    NIH R24HL105333Mar 3, 2012 - Feb 29, 2016
    Role: Co-Investigator
    A Dose Escalation Study to Evaluate the Effect of Inhaled Nitrite on Cardiopulmonary Hemodynamics in Subjects with Pulmonary Hypertension
    Aires Pharmaceuticals PRO 11080686Dec 1, 2011 - Mar 30, 2018
    Role: PI
    Description: This is a phase 2 acute hemodynamic study of the effect of inhaled nitrite on patients with WHO groups 1, 2, and 3 pulmonary hypertension. This study is a pharmacokinetic and safety study as well.
    Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
    NIH P01HL103455Jun 1, 2011 - Apr 30, 2021
    Role: Clinical Core Director
    2010 ASPIRE Young Investigator Research Award, "Right Ventricular Regional Contractile Response to Pulmonary Vascular Disease"
    PFIZER WS857357Nov 15, 2010 - Nov 30, 2011
    Role: PI
    Description: This project aims to quantify the sequence and magnitude of regional RV free wall (RVFW) contractile patterns using a high temporal and spatial resolution optical technique. In particular, how the normal contractile patterns are altered in pressure overload as seen in pulmonary vascular disease, and how such pathologic alterations can be mitigated by sildenafil will be studied via an animal model.
    Morphological and Mechanical Behavior of Right Ventricular Extracellular Matrix
    Pittsburgh Foundation M2010-0052Nov 1, 2010 - Oct 31, 2012
    Role: PI
    Description: The aim of this study is to better understand right ventricular morphology and function via biaxial biomechanics in order to improve outcomes in pulmonary hypertension.
    Right Ventricular Morphological and Mechanical Behavior
    American Heart Association 10BGIA3790022Jul 1, 2010 - Jun 30, 2012
    Role: PI
    Description: This is a novel, multidisciplinary approach to elucidate right ventricular (RV) myocardium mechanical behavior in the passive and active states to evaluate the effects of disease and treatment in a rat model of pulmonary hypertension. Unique tissue level bi-axial stress-strain data will be acquired to ultimately allow the connection between organ and cellular level events. A long-term goal will be to use the methodology developed with this project to quantify the RV mechanical behavior regionally and relate this to remodeling changes of the RV and extracellular matrix.
    University of Pittsburgh Clinical and Translational Science Institute
    NIH UL1TR000005Sep 30, 2006 - Jun 30, 2016
    Role: Medical Director of the Vascular Translational Research Center (CTRC) 12/1/2014 - 6/30/2016
    Right Ventricular Structure & Function
    NIH KL2RR024154Jul 1, 2006 - Jun 30, 2011
    Role: Clinical Research Scholar
    Description: The major goal of this multidisciplinary clinical research training grant is to train clinician-researchers. The scholar’s proposal aims to quantify regional right ventricular (RV) performance and develop it as to tool to assess global RV function in the setting of heart failure (HF) and pulmonary hypertension (PH) via a multidisciplinary mentored-sponsored project and a scholar-sponsored project.

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HIV-associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry. Am J Respir Crit Care Med. 2022 05 01; 205(9):1121-1124. Kolaitis NA, Lammi M, Mazimba S, Feldman J, McConnell W, Sager JS, Raval AA, Simon MA, De Marco T. PMID: 35180043.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations With Clinical Outcome Submitted for Publication. J Biomech Eng. 2022 04 01; 144(4). Xu J, Desmond EL, Wong TC, Neill CG, Simon MA, Brigham JC. PMID: 34549255.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension? Am J Respir Crit Care Med. 2022 04 01; 205(7):751-760. Vizza CD, Lang IM, Badagliacca R, Benza RL, Rosenkranz S, White RJ, Adir Y, Andreassen AK, Balasubramanian V, Bartolome S, Blanco I, Bourge RC, Carlsen J, Camacho REC, D'Alto M, Farber HW, Frantz RP, Ford HJ, Ghio S, Gomberg-Maitland M, Humbert M, Naeije R, Orfanos SE, Oudiz RJ, Perrone SV, Shlobin OA, Simon MA, Sitbon O, Torres F, Luc Vachiery J, Wang KY, Yacoub MH, Liu Y, Golden G, Matsubara H. PMID: 34905704.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation. JACC: Basic to Translational Science. 2022. Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen P-S, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K. View Publication.
    5. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. JACC Basic Transl Sci. 2022 Mar; 7(3):265-293. Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K. PMID: 35411324; PMCID: PMC8993767.
      View in: PubMed   Mentions: 1  
    6. An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension. Pulm Circ. 2022 Jan; 12(1):e12024. Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S. PMID: 35506108; PMCID: PMC9053011.
      View in: PubMed   Mentions: 1  
    7. The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study. Front Med (Lausanne). 2021; 8:751338. Sharifi Kia D, Shen Y, Bachman TN, Goncharova EA, Kim K, Simon MA. PMID: 35083230; PMCID: PMC8784691.
      View in: PubMed   Mentions:
    8. An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension. Pulmonary Circulation. 2021. Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S. View Publication.
    9. A clinically applicable strategy to estimate the in vivo distribution of mechanical material properties of the right ventricular wall. Int J Numer Method Biomed Eng. 2022 02; 38(2):e3548. Xu J, Wong TC, Simon MA, Brigham JC. PMID: 34724355.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations with Clinical Outcome Submitted for Publication. J Biomech Eng. 2021; 4(144):044502. Xu J, Desmond EL, Wong T C, Neill CG, Simon MA, Brigham JC. View Publication.
    11. A Clinically Applicable Strategy to Estimate the In Vivo Distribution of Mechanical Material Properties of the Right Ventricular Wall. Int J Numer Meth Biomed Engng. 2021; 2(38):e3548. Xu J, Wong T C, Simon MA, Brigham JC. View Publication.
    12. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 09 14; 78(11):1166-1187. Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. PMID: 34503685; PMCID: PMC8525886.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    13. Role of Internal Jugular Venous Ultrasound in suspected or confirmed Heart Failure: A Systematic Review. J Card Fail. 2022 04; 28(4):639-649. Chaudhary R, Sukhi A, Simon MA, Villanueva FS, Pacella JJ. PMID: 34419599.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Pulmonary Hypertension in the Context of Heart Failure With Preserved Ejection Fraction. Chest. 2021 12; 160(6):2232-2246. Inampudi C, Silverman D, Simon MA, Leary PJ, Sharma K, Houston BA, Vachiéry JL, Haddad F, Tedford RJ. PMID: 34391755; PMCID: PMC8727853.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Gender Differences in Mortality After Left Ventricular Assist Device Implant: A Causal Mediation Analysis Approach. ASAIO J. 2021 06 01; 67(6):614-621. Nayak A, Hu Y, Ko YA, Mehta A, Liu C, Pennington J, Xie R, Cowger J, Kirklin JK, Kormos RL, Simon MA, Morris AA. PMID: 33060408.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. A Pilot Study of Dimethyl Fumarate in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis. J Scleroderma Relat Disord. 2021 Oct 01; 6(3):242-246. Kong K, Koontz D, Morse C, Roth E, Domsic RT, Simon MA, Stratton E, Buchholz C, Tobin-Finch K, Simms R, George MP, Hassoun PM, Farber H, Lafyatis R. PMID: 35005243; PMCID: PMC8741170.
      View in: PubMed   Mentions: 2  
    17. Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension. Front Physiol. 2021; 12:641310. Sharifi Kia D, Kim K, Simon MA. PMID: 34122125; PMCID: PMC8194310.
      View in: PubMed   Mentions: 3  
    18. Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry. Pulm Circ. 2021 Jul-Sep; 11(3):20458940211020913. DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ. PMID: 34158918; PMCID: PMC8186121.
      View in: PubMed   Mentions: 2  
    19. Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Med. 2021 05 10; 13(1):80. Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Morrell NW, Shen Y, Gräf S, Nichols WC, Chung WK. PMID: 33971972; PMCID: PMC8112021.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    20. Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting. IEEE Open Journal of Engineering in Medicine and Biology. 2021; 2:198-200. Bachman TN, Kim K, Simon MA. View Publication.
    21. Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF: Results of the Randomized Placebo-Controlled HELP Trial. JACC Heart Fail. 2021 05; 9(5):360-370. Burkhoff D, Borlaug BA, Shah SJ, Zolty R, Tedford RJ, Thenappan T, Zamanian RT, Mazurek JA, Rich JD, Simon MA, Chung ES, Raza F, Majure DT, Lewis GD, Preston IR, Rich S. PMID: 33839076.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    22. Clinical Differences and Outcomes between Methamphetamine-associated and Idiopathic Pulmonary Arterial Hypertension in the Pulmonary Hypertension Association Registry. Ann Am Thorac Soc. 2021 04; 18(4):613-622. Kolaitis NA, Zamanian RT, de Jesus Perez VA, Badesch DB, Benza RL, Burger CD, Chakinala MM, Elwing JM, Feldman J, Lammi MR, Mathai SC, McConnell JW, Presberg KW, Robinson JC, Sager J, Shlobin OA, Simon MA, Kawut SM, Glidden DV, Singer JP, De Marco T, Pulmonary Hypertension Association Registry Investigators. PMID: 33064950; PMCID: PMC8174020.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    23. Creation and Validation of a Novel Sex-Specific Mortality Risk Score in LVAD Recipients. J Am Heart Assoc. 2021 04 06; 10(7):e020019. Nayak A, Hu Y, Ko YA, Steinberg R, Das S, Mehta A, Liu C, Pennington J, Xie R, Kirklin JK, Kormos RL, Cowger J, Simon MA, Morris AA. PMID: 33764158; PMCID: PMC8174331.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension. J Am Soc Echocardiogr. 2021 08; 34(8):851-861.e1. Hasselberg NE, Kagiyama N, Soyama Y, Sugahara M, Goda A, Ryo-Koriyama K, Batel O, Chakinala M, Simon MA, Gorcsan J. PMID: 33774108.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Prediction of Health-related Quality of Life and Hospitalization in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry. Am J Respir Crit Care Med. 2021 03 15; 203(6):761-764. Min J, Badesch D, Chakinala M, Elwing J, Frantz R, Horn E, Klinger J, Lammi M, Mazimba S, Sager J, Shlobin O, Simon M, Thenappan T, Grinnan D, Ventetuolo C, Al-Naamani N, PHAR Investigators. PMID: 33211974; PMCID: PMC7958508.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Association between Preoperative Dynamic Measures of Vascular Load and Postoperative Hemodynamics in Patients with Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Thromboendarterectomy. Ann Am Thorac Soc. 2021 03; 18(3):551. Contijoch F, Wong D, Igata S, Mizzell AM, Auger W, DeMaria AN, Blanchard D, Waheed A, Bachman TN, Simon MA, Pinsky MR, Madani M. PMID: 33141597; PMCID: PMC7919142.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic? Transplantation. 2021 03 01; 105(3):608-619. Dew MA, Hollenberger JC, Obregon LL, Hickey GW, Sciortino CM, Lockard KL, Kunz NM, Mathier MA, Ramani RN, Kilic A, McNamara DM, Simon MA, Keebler ME, Kormos RL. PMID: 32345866.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Right ventricular load and contractility in HIV-associated pulmonary hypertension. PLoS One. 2021; 16(2):e0243274. Rajaratnam A, Rehman S, Sharma P, Singh VK, Saul M, Vanderpool RR, Gladwin MT, Simon MA, Morris A. PMID: 33621231; PMCID: PMC7901734.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload. Sci Rep. 2021 02 11; 11(1):3587. Sharifi Kia D, Fortunato R, Maiti S, Simon MA, Kim K. PMID: 33574400; PMCID: PMC7878470.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    30. Shape-based strategy for inverse estimation of soft tissue mechanical material properties from untagged medical imaging data. J Eng Mech. 2021; 8(147):04021046. Xu J, Zupan R, Simon M, Wong T, Brigham JC. View Publication.
    31. A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension. Ther Adv Respir Dis. 2021 Jan-Dec; 15:17534666211013688. Coons JC, Crisamore K, Adams S, Modany A, Simon MA, Zhao W, Shaik IH, Venkataramanan R, Empey PE. PMID: 33929912; PMCID: PMC8111525.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Induced bioresistance via BNP detection for machine learning-based risk assessment. Biosens Bioelectron. 2021 Mar 01; 175:112903. So S, Khalaf A, Yi X, Herring C, Zhang Y, Simon MA, Akcakaya M, Lee S, Yun M. PMID: 33370705.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension. JACC Basic Transl Sci. 2020 Nov; 5(11):1073-1092. Sun W, Tang Y, Tai YY, Handen A, Zhao J, Speyer G, Al Aaraj Y, Watson A, Romanelli ME, Sembrat J, Rojas M, Simon MA, Zhang Y, Lee J, Xiong Z, Dutta P, Vasamsetti SB, McNamara D, McVerry B, McTiernan CF, Sciurba FC, Kim S, Smith KA, Mazurek JA, Han Y, Vaidya A, Nouraie SM, Kelly NJ, Chan SY. PMID: 33294740; PMCID: PMC7691287.
      View in: PubMed   Mentions: 2  
    34. Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR). Ann Am Thorac Soc. 2020 10 21. Min J, Feng R, Badesch D, Berman-Rosenzweig E, Burger C, Chakinala M, De Marco T, Feldman J, Hemnes A, Horn EM, Lammi MR, Mathai S, McConnell JW, Presberg K, Robinson J, Sager J, Shlobin OA, Simon M, Thenappan T, Ventetuolo C, Al-Naamani N, PHAR Investigators. PMID: 33085915; PMCID: PMC7869778.
      View in: PubMed   Mentions: 5     Fields:    
    35. Nationwide variability in the use of induction immunosuppression for adult heart transplantation. J Card Surg. 2020 Nov; 35(11):3053-3061. Diaz-Castrillon CE, Seese L, Mathier MA, Keebler ME, Hickey GW, McNamara D, Simon MA, Horn E, Kilic A. PMID: 33016378.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure. Am Heart J. 2020 12; 230:35-43. Mentz RJ, Xu H, O'Brien EC, Thomas L, Alexy T, Gupta B, Vilaro J, Lala A, DeVore AD, Dhingra R, Briasoulis A, Simon MA, Stehlik J, Rodgers JE, Dunlay SM, Abshire M, Wells QS, Barringhaus KG, Eckman PM, Lowes BD, Espinoza J, Blanco R, Shen X, Duffy CI, Hernandez AF. PMID: 32980364.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Diversity, Equity, and Inclusiveness in Medicine and Cardiology: Next Steps for JAHA. J Am Heart Assoc. 2020 10 20; 9(20):e019307. London B, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Simon MA, Sullivan LM, Weinberg JM. PMID: 32941090; PMCID: PMC7763382.
      View in: PubMed   Mentions: 1     Fields:    
    38. Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care. J Am Heart Assoc. 2020 10 20; 9(20):e019137. Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM. PMID: 32941102; PMCID: PMC7763380.
      View in: PubMed   Mentions: 2     Fields:    
    39. J Am Heart Assoc. Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care. 2020; 9(20):e019137. Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM. View Publication.
    40. United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics. Chest. 2021 01; 159(1):311-327. Badlam JB, Badesch DB, Austin ED, Benza RL, Chung WK, Farber HW, Feldkircher K, Frost AE, Poms AD, Lutz KA, Pauciulo MW, Yu C, Nichols WC, Elliott CG, USPHSR Investigators. PMID: 32858008; PMCID: PMC7803940.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Metformin in Pulmonary Hypertension in Left Heart Disease. Front Med (Lausanne). 2020; 7:425. Mulkareddy V, Simon MA. PMID: 32974359; PMCID: PMC7466644.
      View in: PubMed   Mentions: 2  
    42. Clearing Our Vision for Discerning Precapillary From Postcapillary Pulmonary Hypertension With the OPTICS Risk Score. J Am Heart Assoc. 2020 08 04; 9(15):e017685. Simon MA, Vachiéry JL. PMID: 32750289; PMCID: PMC7792237.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension. J Am Heart Assoc. 2020 07 07; 9(13):e015708. Sharifi Kia D, Benza E, Bachman TN, Tushak C, Kim K, Simon MA. PMID: 32552157; PMCID: PMC7670537.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    44. The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients With Pulmonary Hypertension Associated with Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 Aug; 26(8):654-661. Bashline MJ, Bachman TN, Helbling NL, Nouraie M, Gladwin MT, Simon MA. PMID: 32446946.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    45. mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling? Am J Respir Crit Care Med. 2020 05 15; 201(10):1177-1179. Goncharova EA, Simon MA, Yuan JX. PMID: 31968178; PMCID: PMC7233339.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Outcomes of Pulmonary Arterial Hypertension Are Improved in a Specialty Care Center. Chest. 2020 07; 158(1):330-340. Pi H, Kosanovich CM, Handen A, Tao M, Visina J, Vanspeybroeck G, Simon MA, Risbano MG, Desai A, Mathier MA, Rivera-Lebron BN, Nguyen Q, Kliner J, Nouraie M, Chan SY. PMID: 32109446; PMCID: PMC7339236.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach. Int J Artif Organs. 2020 May; 43(5):297-314. Bellavia D, Iacovoni A, Agnese V, Falletta C, Coronnello C, Pasta S, Novo G, di Gesaro G, Senni M, Maalouf J, Sciacca S, Pilato M, Simon M, Clemenza F, Gorcsan SJ. PMID: 31830841.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension. Genome Med. 2019 11 14; 11(1):69. Zhu N, Pauciulo MW, Welch CL, Lutz KA, Coleman AW, Gonzaga-Jauregui C, Wang J, Grimes JM, Martin LJ, He H, PAH Biobank Enrolling Centers’ Investigators, Shen Y, Chung WK, Nichols WC. PMID: 31727138; PMCID: PMC6857288.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    49. Use of Tricuspid Annular Plane Systolic Excursion/Pulmonary Artery Systolic Pressure As a Non-Invasive Method to Assess Right Ventricular-PA Coupling in Patients With Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 09; 12(9):e009648. Bashline MJ, Simon MA. PMID: 31500450; PMCID: PMC6859895.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    50. Pulmonary Hypertension in Patients with Heart Failure with Preserved Ejection Fraction. Where to Draw the Line. Am J Respir Crit Care Med. 2019 08 01; 200(3):278-279. Simon MA, Maron BA. PMID: 31038986; PMCID: PMC6680312.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients. PLoS One. 2019; 14(7):e0220490. Nguyen QL, Wang Y, Helbling N, Simon MA, Shiva S. PMID: 31365585; PMCID: PMC6668825.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    52. Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018. Annu Rev Biomed Eng. 2019 06 04; 21:33-60. Simon MA, Bachman TN, Watson J, Baldwin JT, Wagner WR, Borovetz HS. PMID: 31167107.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    53. Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension. Pulm Circ. 2019 Apr-Jun; 9(2):2045894019840646. Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY. PMID: 30854934; PMCID: PMC6440051.
      View in: PubMed   Mentions: 7  
    54. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2019 03; 7(3):227-238. Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium. PMID: 30527956; PMCID: PMC6391516.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    55. Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Macaca mulatta) Model of HIV Infection. Comp Med. 2018 12 01; 68(6):461-473. Tarantelli RA, Schweitzer F, Simon MA, Vanderpool RR, Christman I, Rayens E, Kling HM, Zullo T, Carney JP, Lopresti BJ, Bertero T, Chan SY, Norris KA. PMID: 30541636; PMCID: PMC6310202.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    56. Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction-Reply. JAMA Cardiol. 2018 10 01; 3(10):1023-1024. Simon MA, Nouraie M, Gladwin MT. PMID: 30027277.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 09; 59(3):334-345. Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. PMID: 29652520; PMCID: PMC6189645.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    58. Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction. Trends Cardiovasc Med. 2019 05; 29(4):207-217. Levine AR, Simon MA, Gladwin MT. PMID: 30177249; PMCID: PMC6378124.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    59. Right ventricle to pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation. Heart. 2019 01; 105(2):117-121. Sultan I, Cardounel A, Abdelkarim I, Kilic A, Althouse AD, Sharbaugh MS, Gupta A, Xu J, Fukui M, Simon MA, Schindler JT, Lee JS, Gleason TG, Cavalcante JL. PMID: 30093545; PMCID: PMC6320315.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    60. Bedside Ultrasound Assessment of Jugular Venous Compliance as a Potential Point-of-Care Method to Predict Acute Decompensated Heart Failure 30-Day Readmission. J Am Heart Assoc. 2018 08 07; 7(15):e008184. Simon MA, Schnatz RG, Romeo JD, Pacella JJ. PMID: 30371245; PMCID: PMC6201476.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    61. Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2018 04 01; 3(4):298-306. Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA. PMID: 29541759; PMCID: PMC5875307.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    62. Impact of four times daily dosing of oral treprostinil on tolerability and daily dose achieved in pulmonary hypertension. Pulm Circ. 2018 Jan-Mar; 8(1):2045893217744512. Coons JC, Bunner C, Ishizawar DC, Risbano MG, Rivera-Lebron B, Mathier MA, Chan SY, Simon MA. PMID: 29199910; PMCID: PMC5731722.
      View in: PubMed   Mentions: 2  
    63. Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension. APL Bioeng. 2017 Dec; 1(1). Avazmohammadi R, Hill M, Simon M, Sacks M. PMID: 30417163; PMCID: PMC6224170.
      View in: PubMed   Mentions: 17  
    64. Bosentan-based, treat-to-target therapy in patients with pulmonary arterial hypertension: results from the COMPASS-3 study. Pulm Circ. 2018 Jan-Mar; 8(1):2045893217741480. Benza RL, Raina A, Gupta H, Murali S, Burden A, Zastrow MS, Park MH, Simon MA. PMID: 29064349; PMCID: PMC5798685.
      View in: PubMed   Mentions: 4  
    65. Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance. J Am Heart Assoc. 2017 Sep 12; 6(9). Jang S, Vanderpool RR, Avazmohammadi R, Lapshin E, Bachman TN, Sacks M, Simon MA. PMID: 28899895; PMCID: PMC5634275.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    66. Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome. JAMA Cardiol. 2017 09 01; 2(9):995-1006. Schelbert EB, Fridman Y, Wong TC, Abu Daya H, Piehler KM, Kadakkal A, Miller CA, Ugander M, Maanja M, Kellman P, Shah DJ, Abebe KZ, Simon MA, Quarta G, Senni M, Butler J, Diez J, Redfield MM, Gheorghiade M. PMID: 28768311; PMCID: PMC5710176.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    67. How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension. Eur Respir J. 2017 08; 50(2). Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP. PMID: 28838981; PMCID: PMC6330704.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    68. Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity. JCI Insight. 2017 03 09; 2(5):e91415. Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S. PMID: 28289721; PMCID: PMC5333965.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    69. Comprehensive Right-Sided Assessment for Transcatheter Aortic Valve Replacement Risk Stratification: Time for a Change. J Am Soc Echocardiogr. 2017 01; 30(1):47-51. Cavalcante JL, Simon MA, Chan SY. PMID: 28063482; PMCID: PMC5813684.
      View in: PubMed   Mentions: 9     Fields:    
    70. Chemokine receptor patterns and right heart failure in mechanical circulatory support. J Heart Lung Transplant. 2017 Jun; 36(6):657-665. Nayak A, Neill C, Kormos RL, Lagazzi L, Halder I, McTiernan C, Larsen J, Inashvili A, Teuteberg J, Bachman TN, Hanley-Yanez K, McNamara DM, Simon MA. PMID: 28209402; PMCID: PMC5446283.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    71. Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction. JCI Insight. 2016 11 03; 1(18):e89620. Simon MA, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J, Parsley EL, Gladwin MT. PMID: 27812547; PMCID: PMC5085611.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCTClinical Trials
    72. Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing. PLoS One. 2016; 11(10):e0165320. Park DW, Sebastiani A, Yap CH, Simon MA, Kim K. PMID: 27780271; PMCID: PMC5079565.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    73. A novel constitutive model for passive right ventricular myocardium: evidence for myofiber-collagen fiber mechanical coupling. Biomech Model Mechanobiol. 2017 04; 16(2):561-581. Avazmohammadi R, Hill MR, Simon MA, Zhang W, Sacks MS. PMID: 27696332; PMCID: PMC5352519.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    74. Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. J Clin Invest. 2016 09 01; 126(9):3313-35. Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. PMID: 27548520; PMCID: PMC5004943.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    75. Simple functional imaging of the right ventricle in pulmonary hypertension: Can right ventricular ejection fraction be improved? Int J Cardiol. 2016 Nov 15; 223:93-94. Vanderpool RR, Rischard F, Naeije R, Hunter K, Simon MA. PMID: 27532240; PMCID: PMC5067211.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    76. Update in Pulmonary Vascular Disease 2015. Am J Respir Crit Care Med. 2016 06 15; 193(12):1337-44. Maron BA, Gladwin MT, Simon MA. PMID: 27304242; PMCID: PMC4910895.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    77. Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel. J Vasc Interv Radiol. 2016 Jun; 27(6):787-94. Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, Kearon C. PMID: 27287967.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    78. The Prognostic Utility of a Simplified Biventricular Echocardiographic Index of Cardiac Remodeling in Patients with Pulmonary Hypertension. J Am Soc Echocardiogr. 2016 06; 29(6):554-60. Goda A, Ryo K, Delgado-Montero A, Tayal B, Handa R, Simon MA, Gorcsan J. PMID: 27049663.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    79. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients transitioned from parenteral or inhaled prostacyclins: case series and treatment protocol. Pulm Circ. 2016 Mar; 6(1):132-5. Coons JC, Miller T, Simon MA, Ishizawar DC, Mathier MA. PMID: 27162621; PMCID: PMC4860543.
      View in: PubMed   Mentions: 6  
    80. Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography. Circ Cardiovasc Imaging. 2015 Jun; 8(6). Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J. PMID: 26038432.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    81. MY APPROACH to the patient with right ventricular failure. Trends Cardiovasc Med. 2015 Jul; 25(5):471-2. Simon MA. PMID: 25983075.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    82. Methods for using 3-D ultrasound speckle tracking in biaxial mechanical testing of biological tissue samples. Ultrasound Med Biol. 2015 Apr; 41(4):1029-42. Yap CH, Park DW, Dutta D, Simon M, Kim K. PMID: 25616585; PMCID: PMC4346411.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    83. Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease. PLoS One. 2014; 9(12):e114309. Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT. PMID: 25478953; PMCID: PMC4257593.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    84. Non-invasive screening for cardiac allograft vasculopathy: go small or go home? J Heart Lung Transplant. 2015 Feb; 34(2):158-60. Teuteberg JJ, Simon MA. PMID: 25511745.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    85. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart. 2015 Jan; 101(1):37-43. Vanderpool RR, Pinsky MR, Naeije R, Deible C, Kosaraju V, Bunner C, Mathier MA, Lacomis J, Champion HC, Simon MA. PMID: 25214501; PMCID: PMC4268056.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    86. Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction. Ann Am Thorac Soc. 2014 Sep; 11(7):1101-15. Gomez-Arroyo J, Sandoval J, Simon MA, Dominguez-Cano E, Voelkel NF, Bogaard HJ. PMID: 25079379.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    87. Structural and mechanical adaptations of right ventricle free wall myocardium to pressure overload. Ann Biomed Eng. 2014 Dec; 42(12):2451-65. Hill MR, Simon MA, Valdez-Jasso D, Zhang W, Champion HC, Sacks MS. PMID: 25164124; PMCID: PMC4241140.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    88. A comparative analysis of global shape analysis methods for the assessment of the human right ventricle. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 2014; 4(6):327-343. Wu J, Simon MA, Brigham JC. View Publication.
    89. An implementation of independent component analysis for 3D statistical shape analysis. Biomedical Signal Processing and Control. 2014; 13:345-356. Wu J, Brigham KG, Simon M, Brigham JC. View Publication.
    90. Biocompatibility Assessment of the CentriMag-Novalung Adult ECMO Circuit in a Model of Acute Pulmonary Hypertension. ASAIO J. 2014 Jul-Aug; 60(4):429-35. Shankarraman V, Kocyildirim E, Olia SE, Kameneva MV, Dzadony RJ, Maul TM, Simon MA, Champion HC, Wagner WR, Bermudez CA. PMID: 24658516; PMCID: PMC4320026.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    91. Isolated right ventricular dysfunction in patients with human immunodeficiency virus. J Card Fail. 2014 Jun; 20(6):414-421. Simon MA, Lacomis CD, George MP, Kessinger C, Weinman R, McMahon D, Gladwin MT, Champion HC, Morris A. PMID: 24726418; PMCID: PMC4057918.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    92. Advances in Pulmonary Hypertension. Nitric Oxide Therapeutics in Pulmonary Vascular Disease. 2014; 13(3):134-137. Simon MA. View Publication.
    93. First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease. Pulm Circ. 2013 Dec; 3(4):952-8. George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT. PMID: 25006411; PMCID: PMC4070828.
      View in: PubMed   Mentions: 4  
    94. Matrix metalloproteinases in right ventricular failure. Nat Rev Cardiol. 2013 Oct; 10(10):559. Simon MA. PMID: 23959227.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    95. Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J. 2014 Mar; 35(10):657-64. Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, Mulukutla SR, Simon MA, Shroff SG, Kuller LH, Schelbert EB. PMID: 23756336; PMCID: PMC3945798.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    96. A Novel Acquisition Technique to Utilize Swan-Ganz Catheter data as a Surrogate for High-fidelity Micromanometry within the Right Ventricle and Pulmonary Circuit. Cardiovasc Eng Technol. 2013 Jun 01; 4(2):183-191. Bachman TN, Bursic JJ, Simon MA, Champion HC. PMID: 25484997; PMCID: PMC4254723.
      View in: PubMed   Mentions: 9     Fields:    
    97. Standing the test of time: exercise testing for heart failure prognosis in the beta-blocker era. Turk Kardiyol Dern Ars. 2013 Mar; 41(2):113-4. Simon M, Soran O. PMID: 23666297.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    98. A new computational framework for anatomically consistent 3D statistical shape analysis with clinical imaging applications. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 2013; 1(1):13-27. Wu J, Wang Y, Simon MA, Sacks MS, Brigham JC. View Publication.
    99. Assessment and treatment of right ventricular failure. Nat Rev Cardiol. 2013 Apr; 10(4):204-18. Simon MA. PMID: 23399974.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    100. Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography. J Cardiovasc Magn Reson. 2013 Jan 16; 15:6. Wong TC, Piehler K, Puntil KS, Moguillansky D, Meier CG, Lacomis JM, Kellman P, Cook SC, Schwartzman DS, Simon MA, Mulukutla SR, Schelbert EB. PMID: 23324403; PMCID: PMC3599652.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    101. Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2013 Mar; 48(3):374-81. George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. PMID: 23239493; PMCID: PMC3604086.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    102. A new approach to kinematic feature extraction from the human right ventricle for classification of hypertension: a feasibility study. Phys Med Biol. 2012 Dec 07; 57(23):7905-22. Wu J, Wang Y, Simon MA, Brigham JC. PMID: 23154583.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    103. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation. 2012 Sep 04; 126(10):1206-16. Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, Shakesprere J, Kellman P, Shroff SG, Schwartzman DS, Mulukutla SR, Simon MA, Schelbert EB. PMID: 22851543; PMCID: PMC3464491.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansCells
    104. A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium. J Physiol. 2012 Sep 15; 590(18):4571-84. Valdez-Jasso D, Simon MA, Champion HC, Sacks MS. PMID: 22848044; PMCID: PMC3477758.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    105. Comparison of outcomes for patients with nonischemic cardiomyopathy taking intravenous inotropes versus those weaned from or never taking inotropes at cardiac resynchronization therapy. Am J Cardiol. 2012 Sep 15; 110(6):857-61. Adelstein E, Bhattacharya S, Simon MA, Gorcsan J, Saba S. PMID: 22681865.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    106. Prognosis of right ventricular failure in patients with left ventricular assist device based on decision tree with SMOTE. IEEE Trans Inf Technol Biomed. 2012 May; 16(3):383-90. Wang Y, Simon M, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF. PMID: 22334033.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    107. Survival benefit of implantable cardioverter-defibrillators in left ventricular assist device-supported heart failure patients. J Card Fail. 2012 Feb; 18(2):140-5. Refaat MM, Tanaka T, Kormos RL, McNamara D, Teuteberg J, Winowich S, London B, Simon MA. PMID: 22300782; PMCID: PMC3272629.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    108. Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device. J Heart Lung Transplant. 2012 Feb; 31(2):140-9. Wang Y, Simon MA, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF. PMID: 22168963; PMCID: PMC3273573.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    109. Impact of renal function before mechanical circulatory support on posttransplant renal outcomes. Ann Thorac Surg. 2011 May; 91(5):1348-54. Singh M, Shullo M, Kormos RL, Lockard K, Zomak R, Simon MA, Bermudez C, Bhama J, McNamara D, Toyoda Y, Teuteberg JJ. PMID: 21524442.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    110. Left ventricular mechanical dyssynchrony in acute onset cardiomyopathy: association of its resolution with improvements in ventricular function. JACC Cardiovasc Imaging. 2011 May; 4(5):445-56. Tanaka H, Tanabe M, Simon MA, Starling RC, Markham D, Thohan V, Mather P, McNamara DM, Gorcsan J. PMID: 21565730.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    111. Right ventricular dysfunction and failure in chronic pressure overload. Cardiol Res Pract. 2011 Mar 23; 2011:568095. Simon MA, Pinsky MR. PMID: 21559218; PMCID: PMC3087982.
      View in: PubMed   Mentions: 15  
    112. Role of cardiac resynchronization in end-stage heart failure patients requiring inotrope therapy. J Card Fail. 2010 Dec; 16(12):931-7. Bhattacharya S, Abebe K, Simon M, Saba S, Adelstein E. PMID: 21111981; PMCID: PMC3072753.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    113. Early adverse events as predictors of 1-year mortality during mechanical circulatory support. J Heart Lung Transplant. 2010 Sep; 29(9):981-8. Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL. PMID: 20580265; PMCID: PMC2926204.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    114. Right ventricular adaptation to pressure overload. Curr Opin Crit Care. 2010 Jun; 16(3):237-43. Simon MA. PMID: 20179591.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    115. Detection of elevated right atrial pressure using a simple bedside ultrasound measure. Am Heart J. 2010 Mar; 159(3):421-7. Simon MA, Kliner DE, Girod JP, Moguillansky D, Villanueva FS, Pacella JJ. PMID: 20211304.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    116. Pulsatile left ventricular assist device support as a bridge to decision in patients with end-stage heart failure complicated by pulmonary hypertension. J Heart Lung Transplant. 2010 Feb; 29(2):201-8. Nair PK, Kormos RL, Teuteberg JJ, Mathier MA, Bermudez CA, Toyoda Y, Dew MA, Simon MA. PMID: 20113910; PMCID: PMC3066206.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    117. Left ventricular remodeling and myocardial recovery on mechanical circulatory support. J Card Fail. 2010 Feb; 16(2):99-105. Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan J, McNamara DM. PMID: 20142020; PMCID: PMC2819986.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    118. Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension. Congest Heart Fail. 2009 Nov-Dec; 15(6):271-6. Simon MA, Rajagopalan N, Mathier MA, Shroff SG, Pinsky MR, López-Candales A. PMID: 19925505; PMCID: PMC2884997.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    119. Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation. Ann Thorac Surg. 2009 Oct; 88(4):1162-70. Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Kay J, Siegenthaler MP, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL. PMID: 19766801; PMCID: PMC2763436.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    120. Identifying left ventricular dysfunction in pulmonary hypertension. Congest Heart Fail. 2009 Sep-Oct; 15(5):218-21. Rajagopalan N, Simon MA, Edelman K, Mathier MA, López-Candales A. PMID: 19751422.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    121. Phenotyping the right ventricle in patients with pulmonary hypertension. Clin Transl Sci. 2009 Aug; 2(4):294-9. Simon MA, Deible C, Mathier MA, Lacomis J, Goitein O, Shroff SG, Pinsky MR. PMID: 20443908; PMCID: PMC2907237.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    122. Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function. Pacing Clin Electrophysiol. 2009 Feb; 32(2):224-33. Johnson L, Simon MA, Pinsky MR, Shroff SG. PMID: 19170912; PMCID: PMC2948864.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    123. Noninvasive estimation of pulmonary vascular resistance in pulmonary hypertension. Echocardiography. 2009 May; 26(5):489-94. Rajagopalan N, Simon MA, Suffoletto MS, Shah H, Edelman K, Mathier MA, López-Candales A. PMID: 19054039.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    124. Utility of right ventricular tissue Doppler imaging: correlation with right heart catheterization. Echocardiography. 2008 Aug; 25(7):706-11. Rajagopalan N, Simon MA, Shah H, Mathier MA, López-Candales A. PMID: 18445057.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    125. Hemodynamic information and analysis of cardiac pumping. Journal of Mechanics in Medicine and Biology. 2008; 8(1):87-95. Hung TK, Balasubramanian SR, Simon MA, Suffoletto M, Borovetz HS, Gorcsan J. View Publication.
    126. Current and future considerations in the use of mechanical circulatory support devices. Annu Rev Biomed Eng. 2008; 10:59-84. Simon MA, Watson J, Baldwin JT, Wagner WR, Borovetz HS. PMID: 18647112.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    127. Identifying right ventricular dysfunction with tissue Doppler imaging in pulmonary hypertension. Int J Cardiol. 2008 Aug 29; 128(3):359-63. Rajagopalan N, Simon MA, Mathier MA, López-Candales A. PMID: 17714807.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    128. Right ventricular function following cardiac resynchronization therapy. Am J Cardiol. 2007 Nov 01; 100(9):1434-6. Rajagopalan N, Suffoletto MS, Tanabe M, Miske G, Thomas NC, Simon MA, Bazaz R, Gorcsan J, López-Candales A. PMID: 17950803.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    129. Correlation of tricuspid annular velocities with invasive hemodynamics in pulmonary hypertension. Congest Heart Fail. 2007 Jul-Aug; 13(4):200-4. Rajagopalan N, Saxena N, Simon MA, Edelman K, Mathier MA, López-Candales A. PMID: 17673871.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    130. Right ventricular dyssynchrony in heart failure: a tissue Doppler imaging study. J Card Fail. 2006 May; 12(4):263-7. Rajagopalan N, Dohi K, Simon MA, Suffoletto M, Edelman K, Murali S, López-Candales A. PMID: 16679258.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    131. Differential exercise performance on ventricular assist device support. J Heart Lung Transplant. 2005 Oct; 24(10):1506-12. Simon MA, Kormos RL, Gorcsan J, Dohi K, Winowich S, Stanford E, Carozza L, Murali S. PMID: 16210122.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    132. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Circulation. 2005 Aug 30; 112(9 Suppl):I32-6. Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM. PMID: 16159839.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    133. Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers. J Card Fail. 2004 Feb; 10(1):15-20. Shakar SF, Lowes BD, Lindenfeld J, Zolty R, Simon M, Robertson AD, Bristow MR, Wolfel EE. PMID: 14966770.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    134. Inotropes in the beta-blocker era. Clin Cardiol. 2000 Mar; 23(3 Suppl):III11-6. Lowes BD, Simon MA, Tsvetkova TO, Bristow MR. PMID: 10754776; PMCID: PMC6655120.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
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