Daniel Calabrese, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #1179A
San Francisco CA 94117
Phone415-476-0735
ORCID ORCID Icon0000-0002-0596-3434 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. Louis, St. LouisBS05/2006Anthropology, Biology
    Case Western Reserve University, ClevelandMD05/2011
    University of Washington, SeattleResidency07/2014Internal Medicine
    University of California San FranciscoFellowship07/2018Pulmonary and Critical Care
    University of California San Francisco, San Francisco2020Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    ISHLT2022  - 2023Research and Immunology Professional Community Award for Excellence
    ASCI2023  - 2023Young Physician-Scientist Award

    Collapse Overview 
    Collapse Overview
    Dr. Calabrese is an Assistant Professor of Medicine at UCSF and a Staff Physician at the San Francisco VA Medical Center. He received his undergraduate degree from Washington University in St. Louis and completed his MD at Case Western Reserve University School of Medicine.

    He serves as an attending physician in the intensive care unit, pulmonary consult service and outpatient pulmonary clinic at the SF VAMC. He is also an attending physician for the Advanced Lung Disease Service at UCSF Parnassus where he evaluates patients in the lung transplant clinics. He is active in the International Society for Heart and Lung Transplantation.

    His research focuses on the mechanisms for innate immune inflammation in lung transplant outcomes. This research uses mouse models of human lung disease and human tissue samples to understand primary graft dysfunction, antibody-mediated rejection and chronic lung allograft dysfunction. The goal of this work is to improve outcomes following lung transplantation.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting airway hypoxia pathways in Cystic Fibrosis
    Cystic Fibrosis Foundation CALABR22G0Aug 1, 2022 - Jul 31, 2024
    Role: PI
    NKG2D stress molecules in lung allograft dysfunction
    American Society of Transplantation Jul 1, 2022 - Jun 30, 2024
    Role: PI
    NK cells in pulmonary ischemia-reperfusion injury
    VA BLRD 1IK2BX005301-01A1Jul 1, 2021 - Jun 30, 2026
    Role: PI
    Natural killer cells in primary graft dysfunction
    Cystic Fibrosis Foundation Harry Shwachman Clinical Investigator AwardJul 1, 2019 - Jun 30, 2022
    Role: PI
    Targeting Antibody-Dependent NK Cell-mediated Rejection Pathways in Lung Allograft Recipients
    ISHLT Joel D Cooper Career Development AwardJul 1, 2019 - Jun 30, 2021
    Role: PI

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Emperor Has Some Clothes: Emerging Molecular Diagnostics in Post-Lung Transplant Decision Making. Am J Respir Crit Care Med. 2024 Feb 22. Calabrese DR, Shaver CM. PMID: 38387008.
      View in: PubMed   Mentions:    Fields:    
    2. Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression. J Heart Lung Transplant. 2024 Feb 15. Calabrese DR, Ekstrand CA, Yellamilli S, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR. PMID: 38367738.
      View in: PubMed   Mentions:    Fields:    
    3. Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction. medRxiv. 2024 Jan 23. Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Kapse B, Greenland JR, Singer JP. PMID: 37873197; PMCID: PMC10593057.
      View in: PubMed   Mentions:
    4. MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death. Am J Respir Crit Care Med. 2024 Jan 01; 209(1):70-82. Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR. PMID: 37878820; PMCID: PMC10870895.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI Insight. 2023 Nov 08; 8(21). Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. PMID: 37788115; PMCID: PMC10721259.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction. J Heart Lung Transplant. 2023 12; 42(12):1700-1709. Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ. PMID: 37648073; PMCID: PMC10858720.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies. Am J Transplant. 2023 Dec; 23(12):1826-1827. Calabrese DR, Greenland JR. PMID: 37562578; PMCID: PMC10855672.
      View in: PubMed   Mentions:    Fields:    
    8. Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis. Transplant Direct. 2023 Sep; 9(9):e1495. Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR. PMID: 37575951; PMCID: PMC10414707.
      View in: PubMed   Mentions:
    9. The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation. Transplantation. 2023 10 01; 107(10):2255-2261. Singer JP, Gao Y, Huang CY, Kordahl RC, Sriram A, Hays SR, Kukreja J, Venado A, Calabrese DR, Greenland JR. PMID: 37287095; PMCID: PMC10524113.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Regadenoson Is All the RAGE: Targeting the Inflammatory Cascade in Primary Graft Dysfunction. Ann Thorac Surg. 2023 12; 116(6):1159-1160. Bromberger B, Calabrese DR, Brzezinski M, Kukreja J. PMID: 37062341.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Paradox of Power: Dynamic Tools to Predict Respiratory Failure in Spontaneously Breathing Patients. Anesthesiology. 2023 03 01; 138(3):238-240. Calabrese DR, London MJ. PMID: 36749420.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Development of the Lung Transplant Frailty Scale (LT-FS). J Heart Lung Transplant. 2023 07; 42(7):892-904. Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK. PMID: 36925382.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Subphenotypes of frailty in lung transplant candidates. Am J Transplant. 2023 04; 23(4):531-539. Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD. PMID: 36740192.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function. J Heart Lung Transplant. 2023 06; 42(6):828-837. Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein AB, Singer JP, Hays SR. PMID: 37031033.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision. Am J Respir Crit Care Med. 2023 02 01; 207(3):300-311. Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T. PMID: 36094471; PMCID: PMC9896647.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction. Am J Transplant. 2023 01; 23(1):37-44. Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR. PMID: 36695619; PMCID: PMC10018437.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Frailty and genetic risk predict fracture after lung transplantation. Am J Transplant. 2023 02; 23(2):214-222. Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR. PMID: 36695698; PMCID: PMC10037703.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 12 22; 7(24). Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. PMID: 36346670; PMCID: PMC9869973.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. J Exp Med. 2022 11 07; 219(11). Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL. PMID: 36066491; PMCID: PMC9448639.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. Lymphocytic Airway Inflammation in Lung Allografts. Front Immunol. 2022; 13:908693. Santos J, Calabrese DR, Greenland JR. PMID: 35911676; PMCID: PMC9335886.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. J Clin Invest. 2022 04 01; 132(7). Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Méndez-Ferrer S, Swirski FK, Looney MR. PMID: 35192546; PMCID: PMC8970674.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival. Clin Transplant. 2022 06; 36(6):e14639. Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR. PMID: 35246990; PMCID: PMC9197975.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses. J Heart Lung Transplant. 2022 05; 41(5):641-653. Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR. PMID: 34924263; PMCID: PMC9038662.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    24. Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. Front Immunol. 2021; 12:704172. Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. PMID: 34691018; PMCID: PMC8528961.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    25. Ribavirin to the Rescue: Natural Killer-Cell Function After Hepatitis C Virus Treatment in Liver Transplant Recipients. Transplantation. 2021 10 01; 105(10):2137-2139. Calabrese DR. PMID: 33587428.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Ann Am Thorac Soc. 2021 09; 18(9):1464-1474. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. PMID: 33565917; PMCID: PMC8489868.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    27. Measuring Quality in Lung Transplant Care: The QUILT Initiative. The Journal of Heart and Lung Transplantation. 2021 Apr 1; 40(4):s158. Venado VA, Singer SJ, Leard LL, Shah SR, Kleinhenz KM, Golden GJ, Perez PA, Kolaitis KN, Calabrese CD, Maheshwari MJ, Trinh TB, Kukreja KJ, Hays HS. .
      View in: Publisher Site   Mentions:
    28. Implementation of a Chatbot Mobile Health Intervention with Home Spirometry to Monitor Lung Transplant Recipients Remotely. The Journal of Heart and Lung Transplantation. 2021 Apr 1; 40(4):s146. Odisho OA, Singer SJ, Perez PA, Leard LL, Shah SR, Golden GJ, Kleinhenz KM, Kolaitis KN, Maheshwari MJ, Liu LA, Trinh TB, Kukreja KJ, Greenland GJ, Calabrese CD, Hays HS. .
      View in: Publisher Site   Mentions:
    29. The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation. Clin Transplant. 2021 05; 35(5):e14275. DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J. PMID: 33682171.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Rapid molecular detection of airway pathogens in lung transplant recipients. Transpl Infect Dis. 2021 Aug; 23(4):e13579. Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR. PMID: 33523538; PMCID: PMC8325716.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    31. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. J Clin Invest. 2021 02 01; 131(3). Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR. PMID: 33290276; PMCID: PMC7852842.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    32. Ribavirin to the Rescue: Natural Killer Cell Function After Hepatitis C Virus Treatment in Liver Transplant Recipients. Transplantation. 2020. Daniel R. Calabrese. . View Publication.
    33. Complement activation on endothelium initiates antibody-mediated acute lung injury. J Clin Invest. 2020 11 02; 130(11):5909-5923. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. PMID: 32730229; PMCID: PMC7598054.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. Frailty after lung transplantation is associated with impaired health-related quality of life and mortality. Thorax. 2020 08; 75(8):669-678. Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP. PMID: 32376733; PMCID: PMC8023537.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. Am J Health Syst Pharm. 2019 12 02; 76(24):2019-2027. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. PMID: 31696925; PMCID: PMC7170730.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death. JCI Insight. 2019 11 14; 4(22). Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, LTOG investigators, Greenland JR. PMID: 31613800; PMCID: PMC6948872.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. At the Bottom of Thomas Bayes' Tea Cup: Practical Applications of Lung Transplant Immunophenotyping. Transplantation. 2019 08; 103(8):1538-1539. Calabrese DR. PMID: 30461722.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    38. NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients. Transplantation. 2019 03; 103(3):493-501. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR. PMID: 30211828; PMCID: PMC6389428.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    39. Natural killer cells in lung transplantation. Thorax. 2019 04; 74(4):397-404. Calabrese DR, Lanier LL, Greenland JR. PMID: 30381399; PMCID: PMC6420386.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    40. Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients. Clin Transplant. 2018 08; 32(8):e13332. Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR. PMID: 29920787; PMCID: PMC8103920.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    41. HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Am J Transplant. 2017 Aug; 17(8):2192-2199. Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R. PMID: 28375571; PMCID: PMC5519429.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    42. Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings. Schizophr Res. 2008 Sep; 104(1-3):61-70. Calabrese DR, Wang L, Harms MP, Ratnanather JT, Barch DM, Cloninger CR, Thompson PA, Miller MI, Csernansky JG. PMID: 18692994; PMCID: PMC4256942.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    43. Planar relationships of the semicircular canals in two strains of mice. J Assoc Res Otolaryngol. 2006 Jun; 7(2):151-9. Calabrese DR, Hullar TE. PMID: 16718609; PMCID: PMC2504575.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
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