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Jasleen Kukreja, MD, MPH

Title(s)Professor, Surgery
SchoolSchool of Medicine
Phone415-353-8195
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    University of California Los AngelesM.D.1994School of Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Anderson MR, Udupa JK, Edwin E, Diamond JM, Singer JP, Kukreja J, Hays SR, Greenland JR, Ferrante A, Lippel M, Blue T, McBurnie A, Oyster M, Kalman L, Rushefski M, Wu C, Pednekar G, Liu W, Arcasoy S, Sonett J, D'Ovidio F, Bacchetta M, Newell JD, Torigian D, Cantu E, Farber DL, Giles JT, Tong Y, Palmer S, Ware LB, Hancock WW, Christie JD, Lederer DJ. Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study. J Heart Lung Transplant. 2019 Aug 10. PMID: 31474492.
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    2. Loor G, Warnecke G, Villavicencio MA, Smith MA, Kukreja J, Ardehali A, Hartwig M, Daneshmand MA, Hertz MI, Huddleston S, Haverich A, Madsen JC, Van Raemdonck D. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial. Lancet Respir Med. 2019 Aug 01. PMID: 31378427.
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    3. Anderson MR, Kolaitis NA, Gao Y, Kukreja J, Greenland J, Hays S, Wolters P, Golden J, Diamond J, Palmer S, Arcasoy S, Udupa J, Christie JD, Lederer DJ, Singer JP. A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates. Am J Transplant. 2019 Jul 06. PMID: 31278829.
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    4. Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience. Transpl Infect Dis. 2019 Jun; 21(3):e13084. PMID: 30924986.
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    5. Brzezinski M, Kukreja J, Mitchell JD. Time-efficient, goal-directed, and evidence-based teaching in the ICU. Curr Opin Anaesthesiol. 2019 Apr; 32(2):136-143. PMID: 30817385.
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    6. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clin Transplant. 2019 May; 33(5):e13515. PMID: 30849195.
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    7. Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP. Frailty trajectories in adult lung transplantation: A cohort study. J Heart Lung Transplant. 2019 Jul; 38(7):699-707. PMID: 31005571.
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    8. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR. NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients. Transplantation. 2019 Mar; 103(3):493-501. PMID: 30211828.
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    9. Brzezinski M, Kukreja J, Mitchell JD. Time-efficient, goal-directed, and evidence-based teaching in the ICU. Curr Opin Anaesthesiol. 2019 Feb 08. PMID: 30747726.
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    10. Zhang Y, Jones KD, Achtar-Zadeh N, Green G, Kukreja J, Xu B, Wolters PJ. Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib. Histopathology. 2019 Jan; 74(2):341-349. PMID: 30152895.
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    11. Singer JP, Soong A, Chen J, Shrestha P, Zhuo H, Gao Y, Greenland JR, Hays SR, Kukreja J, Golden J, Gregorich SE, Stewart AL. Development and Preliminary Validation of the Lung Transplant Quality of Life (LT-QOL) Survey. Am J Respir Crit Care Med. 2018 Oct 10. PMID: 30303408.
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    12. Kolaitis NA, Kukreja J, Jones KD, Hays SR, Leard LE. Pirfenidone-Induced Sarcoid-Like Reaction: A Novel Complication. Chest. 2018 Oct; 154(4):e89-e92. PMID: 30290953.
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    13. Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR. Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients. Clin Transplant. 2018 Aug; 32(8):e13332. PMID: 29920787.
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    14. Ramirez JL, Urisman A, Kukreja J, Kratz JR. Surgical Management of Pulmonary Mucormycosis in Third-Trimester Pregnancy. Thorac Cardiovasc Surg Rep. 2018 Jan; 7(1):e27-e29. PMID: 29977735.
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    15. Singer JP, Soong A, Bruun A, Bracha A, Chin G, Hays SR, Kukreja J, Rigler J, Golden JA, Greenland JR, Garvey C. A mobile health technology enabled home-based intervention to treat frailty in adult lung transplant candidates: A pilot study. Clin Transplant. 2018 Jun; 32(6):e13274. PMID: 29742287.
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    16. Greenland JR, Chong T, Wang AS, Martinez E, Shrestha P, Kukreja J, Hays SR, Golden JA, Singer JP, Tang Q. Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection. Am J Transplant. 2018 Aug; 18(8):2043-2049. PMID: 29673076.
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    17. Singer JP, Diamond JM, Anderson MR, Katz PP, Covinsky K, Oyster M, Blue T, Soong A, Kalman L, Shrestha P, Arcasoy SM, Greenland JR, Shah L, Kukreja J, Blumenthal NP, Easthausen I, Golden JA, McBurnie A, Cantu E, Sonett J, Hays S, Robbins H, Raza K, Bacchetta M, Shah RJ, D'Ovidio F, Venado A, Christie JD, Lederer DJ. Frailty phenotypes and mortality after lung transplantation: A prospective cohort study. Am J Transplant. 2018 08; 18(8):1995-2004. PMID: 29667786.
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    18. Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study. Lancet Respir Med. 2018 05; 6(5):357-367. PMID: 29650408.
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    19. Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J. Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Clin Transplant. 2018 04; 32(4):e13210. PMID: 29377268.
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    20. Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP. Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation. J Thorac Cardiovasc Surg. 2018 07; 156(1):440-448.e2. PMID: 29550072.
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    21. Baldwin MR, Singer JP, Huang D, Sell J, Gonzalez WC, Pollack LR, Maurer MS, D'Ovidio FF, Bacchetta M, Sonett JR, Arcasoy SM, Shah L, Robbins H, Hays SR, Kukreja J, Greenland JR, Shah RJ, Leard L, Morrell M, Gries C, Katz PP, Christie JD, Diamond JM, Lederer DJ. Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Ann Am Thorac Soc. 2017 Aug; 14(8):1270-1279. PMID: 28398076.
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    22. Van Raemdonck D, Hartwig MG, Hertz MI, Davis RD, Cypel M, Hayes D, Ivulich S, Kukreja J, Lease ED, Loor G, Mercier O, Paoletti L, Parmar J, Rampolla R, Wille K, Walia R, Keshavjee S. Report of the ISHLT Working Group on primary lung graft dysfunction Part IV: Prevention and treatment: A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2017 10; 36(10):1121-1136. PMID: 28784325.
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    23. Brzezinski M, Gregersen M, Schuch LG, Sawatzki R, Chen JW, Gauger G, Kukreja J, Cason B. Discharge against Medical Advice in Surgical Patients with Posttraumatic Stress Disorder: A Case Report Series Illustrating Unique Challenges. Case Rep Anesthesiol. 2017; 2017:3045907. PMID: 28713596.
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    24. Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R. HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Am J Transplant. 2017 Aug; 17(8):2192-2199. PMID: 28375571.
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    25. Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR. Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Thorax. 2017 11; 72(11):1052-1054. PMID: 28446663.
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    26. Hayes D, Tumin D, Budev MM, Tobias JD, St John RC, Kukreja J. Adverse outcomes associated with pulmonary hypertension in chronic obstructive pulmonary disease after bilateral lung transplantation. Respir Med. 2017 07; 128:102-108. PMID: 28476472.
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    27. Hamilton BC, Kukreja J, Ware LB, Matthay MA. Protein biomarkers associated with primary graft dysfunction following lung transplantation. Am J Physiol Lung Cell Mol Physiol. 2017 04 01; 312(4):L531-L541. PMID: 28130262.
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    28. Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Am J Transplant. 2017 May; 17(5):1334-1345. PMID: 27743488.
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    29. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q. Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 10; 100(10):2090-8. PMID: 27077597.
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    30. Schuch LG, Yip A, Nouri KF, Gregersen M, Cason B, Kukreja J, Wozniak C, Brzezinski M. Serotonin Syndrome Following an Uncomplicated Orthopedic Surgery in a Patient With Post-Traumatic Stress Disorder. Mil Med. 2016 09; 181(9):e1185-8. PMID: 27612381.
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    31. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. PMID: 27362652.
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    32. Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal NP, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation. Am J Respir Crit Care Med. 2015 Dec 01; 192(11):1325-34. PMID: 26258797.
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    33. Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP. Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report. Transplant Proc. 2015 Dec; 47(10):2965-7. PMID: 26707322.
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    34. Mansh M, Binstock M, Williams K, Hafeez F, Kim J, Glidden D, Boettger R, Hays S, Kukreja J, Golden J, Asgari MM, Chin-Hong P, Singer JP, Arron ST. Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients. Am J Transplant. 2016 Jan; 16(1):262-70. PMID: 26372838.
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    35. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015 Jun; 147(6):1558-1565. PMID: 25412059.
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    36. Tokman S, Singer JP, Devine MS, Westall GP, Aubert JD, Tamm M, Snell GI, Lee JS, Goldberg HJ, Kukreja J, Golden JA, Leard LE, Garcia CK, Hays SR. Clinical outcomes of lung transplant recipients with telomerase mutations. J Heart Lung Transplant. 2015 Oct; 34(10):1318-24. PMID: 26169663.
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    37. Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ. Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med. 2014 Nov 01; 190(9):1012-21. PMID: 25233138.
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    38. Hui C, Kern R, Wojciechowski D, Kukreja J, Golden JA, Hays SR, Singer JP. Belatacept for Maintenance Immunosuppression in Lung Transplantation. J Investig Med High Impact Case Rep. 2014 Jul-Sep; 2(3):2324709614546866. PMID: 26425619.
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    39. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015 Jan; 70(1):48-56. PMID: 25217476.
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    40. Woodard GA, Gubens MA, Jahan TM, Jones KD, Kukreja J, Theodore PR, Cardozo S, Jew G, Clary-Macy C, Jablons DM, Mann MJ. Prognostic molecular assay might improve identification of patients at risk for recurrence in early-stage non-small-cell lung cancer. Clin Lung Cancer. 2014 Nov; 15(6):426-32. PMID: 25258195.
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    41. Okoye CC, Jablons DM, Jahan TM, Kukreja J, Cardozo S, Yom SS. Divergent management strategies for typical versus atypical carcinoid tumors of the thoracic cavity. Am J Clin Oncol. 2014 Aug; 37(4):350-5. PMID: 23357970.
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    42. Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul; 11(6):882-9. PMID: 24964265.
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    43. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147.
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    44. Barcia SM, Kukreja J, Jones KD. Pulmonary interstitial emphysema in adults: a clinicopathologic study of 53 lung explants. Am J Surg Pathol. 2014 Mar; 38(3):339-45. PMID: 24525504.
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    45. Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. Am J Transplant. 2014 Apr; 14(4):831-40. PMID: 24512389.
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    46. Singer JP, Blanc PD, Dean YM, Hays S, Leard L, Kukreja J, Golden J, Katz PP. Development and validation of a lung transplant-specific disability questionnaire. Thorax. 2014 May; 69(5):437-42. PMID: 24355825.
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    47. Hayes D, Tobias JD, Kukreja J, Preston TJ, Yates AR, Kirkby S, Whitson BA. Extracorporeal life support for acute respiratory distress syndromes. Ann Thorac Med. 2013 Jul; 8(3):133-41. PMID: 23922607.
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    48. Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, Hays S, Golden JA, Hoopes C, Kukreja J, Singer JP. Outcomes in systemic sclerosis-related lung disease after lung transplantation. Transplantation. 2013 Apr 15; 95(7):975-80. PMID: 23545509.
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    49. Kohi MP, Naeger DM, Kukreja J, Fidelman N, Laberge JM, Gordon RL, Kerlan RK. Preoperative CT-Guided percutaneous wire localization of ground glass pulmonary nodules with a modified Kopans wire. J Thorac Dis. 2013 Apr; 5(2):E31-4. PMID: 23585953.
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    50. Singer JP, Chen J, Blanc PD, Leard LE, Kukreja J, Chen H. A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions. Am J Transplant. 2013 Apr; 13(4):839-850. PMID: 23432992.
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    51. Sayah DM, Schwartz BS, Kukreja J, Singer JP, Golden JA, Leard LE. Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis. Transpl Infect Dis. 2013 Apr; 15(2):E70-4. PMID: 23387799.
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    52. Hoopes CW, Kukreja J, Golden J, Davenport DL, Diaz-Guzman E, Zwischenberger JB. Extracorporeal membrane oxygenation as a bridge to pulmonary transplantation. J Thorac Cardiovasc Surg. 2013 Mar; 145(3):862-7; discussion 867-8. PMID: 23312979.
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    53. Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ. Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res. 2012 Nov 20; 13:105. PMID: 23167970.
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    54. Urisman A, Leard LE, Nathan M, Elicker BM, Hoopes C, Kukreja J, Jones KD. Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptives. J Heart Lung Transplant. 2012 Sep; 31(9):1031-6. PMID: 22884388.
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    55. Ahmad U, Wang Z, Bryant AS, Kim AW, Kukreja J, Mason DP, Bermudez CA, Detterbeck FC, Boffa DJ. Outcomes for lung transplantation for lung cancer in the United Network for Organ Sharing Registry. Ann Thorac Surg. 2012 Sep; 94(3):935-40; discussion 940-1. PMID: 22835555.
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    56. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA. The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Am J Transplant. 2012 Jul; 12(7):1848-54. PMID: 22390401.
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    57. Singer JP, Chen H, Phelan T, Kukreja J, Golden JA, Blanc PD. Survival following lung transplantation for silicosis and other occupational lung diseases. Occup Med (Lond). 2012 Mar; 62(2):134-7. PMID: 22071439.
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    58. Hayes D, Kukreja J, Tobias JD, Ballard HO, Hoopes CW. Ambulatory venovenous extracorporeal respiratory support as a bridge for cystic fibrosis patients to emergent lung transplantation. J Cyst Fibros. 2012 Jan; 11(1):40-5. PMID: 22035707.
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    59. Wood WG, Guy TS, Arora K, Firoozabadi R, Kim H, Kukreja J, Pagel PS, Brzezinski M. Posterior glenohumeral joint dislocation: a rare complication of central venous cannulation in a patient undergoing coronary artery surgery. J Cardiothorac Vasc Anesth. 2013 Feb; 27(1):101-2. PMID: 21862347.
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    60. Brzezinski M, Kukreja J, Mitchell JD, Pagel PS, Tassone RF. Sudden onset of atrial flutter during continuous venovenous hemodialysis. J Cardiothorac Vasc Anesth. 2012 Jun; 26(3):535-6. PMID: 21232978.
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    61. Raz DJ, Gomez SL, Chang ET, Kim JY, Keegan TH, Pham J, Kukreja J, Hiatt RA, Jablons DM. Epidemiology of non-small cell lung cancer in Asian Americans: incidence patterns among six subgroups by nativity. J Thorac Oncol. 2008 Dec; 3(12):1391-7. PMID: 19057262.
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    62. Kukreja J, Jaklitsch MT, Wiener DC, Sugarbaker DJ, Burgers S, Baas P. Malignant pleural mesothelioma: overview of the North American and European experience. Thorac Surg Clin. 2004 Nov; 14(4):435-45. PMID: 15559050.
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    63. Colwell AS, Kukreja J, Breuing KH, Lester S, Orgill DP. Occult breast carcinoma in reduction mammaplasty specimens: 14-year experience. Plast Reconstr Surg. 2004 Jun; 113(7):1984-8. PMID: 15253187.
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    64. Kukreja J, Jaklitsch MT. Section IV: selective use of neoadjuvant therapy. Semin Thorac Cardiovasc Surg. 2003 Apr; 15(2):187-96. PMID: 12838489.
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