Merlin Larson, MD

Title(s)Professor Emeritus, Anesthesia
SchoolSchool of Medicine
AddressLocation Required, #6736
Varies CA 00000
Phone415-885-7412
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    University of Kansas1965

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cortical, subcortical, brainstem and autonomic responses to nociception under total intravenous anesthesia. J Clin Anesth. 2025 Apr; 103:111825. Vide S, Kreuzer M, Ferreira A, Couto M, Agustí M, Jaramillo S, Schneider G, García PS, Abelha F, Amorim P, Trocóniz I, Larson M, Gambús P. PMID: 40220354.
      View in: PubMed   Mentions:    Fields:    
    2. The Pupillary Light-Off Reflex in Acute Disorders of Consciousness. Neurocrit Care. 2025 Apr; 42(2):398-409. Zarifkar P, Othman MH, Hansen KIT, Amiri M, Stückler SG, Fabritius ML, Sigurdsson ST, Hassager C, Birkeland PF, Hauerberg J, Møller K, Kjaergaard J, Larson MD, Kondziella D. PMID: 39322845; PMCID: PMC11950040.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Population study of pupillary unrest in ambient light. Auton Neurosci. 2024 Aug; 254:103197. McKay RE, Kohn M, Schwartz E, Larson MD. PMID: 38996657.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Absence of pupillary reflex dilation in response to a laryngeal test stimulus may predict safe tracheal extubation in anesthetized children. Paediatr Anaesth. 2024 Oct; 34(10):1073-1075. Abelson D, Larson MD. PMID: 38922744.
      View in: PubMed   Mentions:    Fields:    
    5. Measurements of pupillary unrest using infrared pupillometry fail to detect changes in pain intensity in patients after surgery: a prospective observational study. Can J Anaesth. 2024 05; 71(5):611-618. Behrends M, Larson MD. PMID: 38504035; PMCID: PMC11026258.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Overcoming Obstacles: The Legacy of Fidel Pagés, Founder of the Epidural, 100 Years After His Passing. Anesth Analg. 2024 Feb 01; 138(2):475-479. Chinn GA, Gray AT, Larson MD. PMID: 38048631; PMCID: PMC10840793.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Commentary on pupillometry and pain ratings. Eur J Pain. 2023 09; 27(8):925-926. Larson MD. PMID: 37424108.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury. Acta Neurochir (Wien). 2023 06; 165(6):1483-1494. Jakobsen EW, Nersesjan V, Albrechtsen SS, Othman MH, Amiri M, Knudsen NV, Larson MD, Hassager C, Møller K, Kjaergaard J, Kondziella D. PMID: 37014450; PMCID: PMC10227128.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Reader Response: Automated Quantitative Pupillometry in the Critically Ill: A Systematic Review of the Literature. Neurology. 2021 12 14; 97(24):1140. Larson MD. PMID: 34903618.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids. CPT Pharmacometrics Syst Pharmacol. 2022 05; 11(5):581-593. Marco-Ariño N, Vide S, Agustí M, Chen A, Jaramillo S, Irurzun-Arana I, Pacheco A, Gonzalez C, Jensen EW, Capsi-Morales P, Valencia JF, Troconiz IF, Gambus PL, Larson MD. PMID: 34716984; PMCID: PMC9124350.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Detection of Opioid Effect with Pupillometry. Autonomic Neuroscience. 2021; 235. McKay, Rachel Eshima Larson, Merlin D.
    12. Monitoring the Depth of Palliative Sedation by Video-Pupillometry: A Case Report. Palliative Medicine. 2021. Elyn, A Saffon, N Larson, M.
    13. Reader Response: Automated Quantitative Pupillometry in the Critically Ill. Neurology. 2021. Larson, M.
    14. Pupillary unrest, opioid intensity, and the impact of environmental stimulation on respiratory depression. J Clin Monit Comput. 2022 04; 36(2):473-482. McKay RE, Kohn MA, Larson MD. PMID: 33651243; PMCID: PMC9123055.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Evaluation of two portable pupillometers to assess clinical utility. Concussion. 2020 Oct 28; 5(4):CNC82. McKay RE, Kohn MA, Schwartz ES, Larson MD. PMID: 33204494; PMCID: PMC7653507.
      View in: PubMed   Mentions: 5  
    16. Nociceptive monitor subtypes. Comment on 'Objective monitoring of nociception: a review of current commercial solutions' (Br J Anaesth 2019; 123:e312-e321). Br J Anaesth. 2019 10; 123(4):e485-e486. Larson M, Neice A. PMID: 31371019.
      View in: PubMed   Mentions:    Fields:    
    17. Pharmacodynamic modelling of the effect of remifentanil using the Pupillary Pain Index. J Clin Monit Comput. 2020 Apr; 34(2):319-324. Vide S, Castro A, Antunes P, Lima D, Larson M, Gambús P, Amorim P. PMID: 31119519.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Suppression of pupillary unrest by general anesthesia and propofol sedation. J Clin Monit Comput. 2019 Apr; 33(2):317-323. Behrends M, Larson MD, Neice AE, Bokoch MP. PMID: 29785552.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    19. Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions. A A Pract. 2018 May 15; 10(10):279-282. McKay RE, Neice AE, Larson MD. PMID: 29608463.
      View in: PubMed   Mentions: 5     Fields:    
    20. In Response. Anesth Analg. 2017 08; 125(2):694-695. Neice AE, Larson MD, Behrends M, Bokoch MP. PMID: 28632538.
      View in: PubMed   Mentions:    Fields:    
    21. Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest. Anesth Analg. 2017 03; 124(3):915-921. Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. PMID: 27941575.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    22. Portable infrared pupillometry in critical care. Crit Care. 2016 Jun 22; 20(1):161. Larson MD, Singh V. PMID: 27329287; PMCID: PMC4916536.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Portable infrared pupillometry: a review. Anesth Analg. 2015 Jun; 120(6):1242-53. Larson MD, Behrends M. PMID: 25988634.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    24. Pupillary Reflex Dilation to Predict Movement: A Step Forward Toward Real-time Individualized Intravenous Anesthetics. Anesthesiology. 2015 May; 122(5):961-3. Larson MD, Gupta DK. PMID: 25730337.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Auton Neurosci. 2015 May; 189:68-74. Bokoch MP, Behrends M, Neice A, Larson MD. PMID: 25737234.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    26. Pupillary effects of high-dose opioid quantified with infrared pupillometry. Anesthesiology. 2014 Nov; 121(5):1037-44. Rollins MD, Feiner JR, Lee JM, Shah S, Larson M. PMID: 25068603.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    27. Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series. Resuscitation. 2012 Oct; 83(10):1223-8. Behrends M, Niemann CU, Larson MD. PMID: 22659054.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    28. Pupillometry to guide postoperative analgesia. Anesthesiology. 2012 May; 116(5):980-2. Larson MD, Sessler DI. PMID: 22433239.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Procedure-specific guidelines. Anesthesiology. 2010 Aug; 113(2):502-3; author reply 503. Stites-Hallett N, Larson MD. PMID: 20657210.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. The effect of ketamine and nitrous oxide on the human pupillary light reflex during general anesthesia. Auton Neurosci. 2010 Jan 15; 152(1-2):108-14. Eilers H, Larson MD. PMID: 19910265.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. Mechanism of opioid-induced pupillary effects. Clin Neurophysiol. 2008 Jun; 119(6):1358-64. Larson MD. PMID: 18397839.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    32. Efficacy of epidural block during general anesthesia. Anesthesiology. 2006 Sep; 105(3):632-3. Larson MD, Fung RS, Infosino AJ, Baba A. PMID: 16932009.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Induction rooms. Bull Anesth Hist. 2006 Apr; 24(2):22-4. Larson MD, Senturk M. PMID: 20503745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Evaluation of the portable infrared pupillometer. Neurosurgery. 2005 Jul; 57(1):198-203; discussion 198-203. Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT. PMID: 15987563.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    35. Tolerance to miotic effects of opioids. Anesthesiology. 2005 Mar; 102(3):701. Kollars JP, Larson MD. PMID: 15731628.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs. 2005 Feb; 37(1):34-40. Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G. PMID: 15794443.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCTClinical Trials
    37. Latency of pupillary reflex dilation during general anesthesia. J Appl Physiol (1985). 2004 Aug; 97(2):725-30. Larson MD, Berry PD, May J, Bjorksten A, Sessler DI. PMID: 15247200.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    38. The effect of antiemetics on pupillary reflex dilation during epidural/general anesthesia. Anesth Analg. 2003 Dec; 97(6):1652-1656. Larson MD. PMID: 14633536.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    39. Mechanism of pupillary reflex dilation in awake volunteers and in organ donors. Anesthesiology. 2003 Dec; 99(6):1281-6. Yang LL, Niemann CU, Larson MD. PMID: 14639139.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    40. Effect of asphyxia on the pupils of brain dead subjects. Resuscitation. 2002 Oct; 55(1):31-6. Larson MD, May J. PMID: 12297351.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Infrared pupillometry during uncal herniation. J Neurosurg Anesthesiol. 2002 Jul; 14(3):223-8. Manley GT, Larson MD. PMID: 12172296.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    42. The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine. Ann N Y Acad Sci. 1997 Mar 15; 813:792-8. Ikeda T, Kurz A, Sessler DI, Go J, Kurz M, Belani K, Larson M, Bjorksten AR, Dechert M, Christensen R. PMID: 9100971.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    43. Alteration of Human Pupillary Light Reflex by General Anesthesia. Anesthesiology Review. 1989; XVI(3):25-29. Larson, Merlin D.
    44. Anaesthesia. Miotic effects of Opioids. 1987; 42(May):566. Larson, Merlin D.
    45. Pupillary Effects of General Anesthesia. Anesthesiology Review. 1985; 13(Jan/Feb):25-31. Larson, Merlin D.
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