Michael Bokoch • UCSF Profiles

Michael Bokoch, MD, PhD

Title(s)	Assistant Professor, Anesthesia
School	School of Medicine
Address	521 Parnassus Avenue San Francisco CA 94117
Phone	415-476-8389
ORCID	0000-0003-1387-9547
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Biography

Education and Training

UCSF	Fellowship	2017	Liver Transplant Anesthesia
UCSF	Residency	2016	Anesthesia
Stanford University, Stanford, CA	M.D.	2011	School of Medicine
Stanford University, Stanford, CA	Ph.D.	2010	Biophysics
Case Western Reserve University, Cleveland, OH	B.S./B.A.	2003	Biology/Chemistry
University of California, San Francisco, CA		2018	Diversity, Equity, and Inclusion Champion Training

Awards and Honors

UCSF	2019 -	2020	William K. Hamilton Award for Excellence in Resident Teaching
UCSF	2015		Jeffrey A. Katz Award, for work ethic and professionalism in patient care
UCSF	2013		Excellence in Medical Student Teaching Award
Stanford University	2011		Allen B. Barbour Award, Excellence in Clinical Medicine
Case Western Reserve University	2003		Phi Beta Kappa, Alpha of Ohio Chapter
Case Western Reserve University	2003		John Schoff Millis Award, Senior with the best academic record
Case Western Reserve University	2003		Mateescu Student Citizenship Award, Dept. of Chemistry
Case Western Reserve University	2003		Daniel Burke Prize, Excellence in both Biology and Chemistry
Case Western Reserve University	2002		Olin Freeman Tower Prize, Excellence in Physical Chemistry
Case Western Reserve University	2001		Merck Index Award, Excellence in Chemistry
Case Western Reserve University	1999 -	2003	Trustees' Scholarship

Overview

Interests

liver transplant anesthesia, vascular anesthesia, acute kidney injury, molecular pharmacology, endothelium, coagulation, beta blockers, pupillometry, G-protein-coupled receptors

In The News

	UCSF Liver Center 2021 Pilot/Feasibility Grant Awardees (07/14/2021)
	A Spring Break Spent with Intent... Case Western Reserve University student shadowing in OR (04/01/2019)
	Fall 2018 Awardees - UCSF Resource Allocation Program (12/21/2018)
	Anesthetic management of patients with acute aortic syndromes (10/17/2018)
	Cover of Biochemistry: Drug Entry from the Lipid Bilayer (10/02/2018)
	Rapid Ventricular Pacing in Thoracic Endovascular Aortic Arch Repair (Audioslides presentation) (03/29/2017)
	Research on rarely studied cell-receptor regions opens door to eliminating drugs' side effects (01/06/2010)

Research

Research Activities and Funding

Angiotensin II in Liver Transplantation: a pilot randomized controlled trial
UCSF Liver Center Pilot/Feasibility Grant for New Investigator NIH P30 DK026743Jun 1, 2021 - May 31, 2022
Role: Principal Investigator
Role Description: The goal of this single-center, randomized controlled, double-blind pilot trial is to assess the safety and efficacy of angiotensin II infusion versus placebo as a 2nd-line vasopressor for the treatment of hypotension during liver transplantation.

Endothelial Activation by Liver Reperfusion Injury in Transplantation
International Anesthesia Research Society IARS Mentored Research AwardJan 1, 2021 - Dec 31, 2022
Role: Principal Investigator (Mentor: Judith Hellman)
Role Description: The goal of this translational study is to determine possible mechanisms by which liver ischemia-reperfusion injury activates the vascular endothelium and leads to end-organ injury during liver transplantation.

Early Detection of Acute Kidney Injury (AKI) by NephroCheck® in the MHALT Trial
BioMérieux, Inc. Investigator Initiated Research collaborationMar 11, 2020 - Dec 31, 2021
Role: Principal Investigator (Mentor: Matthieu Legrand)

A Randomized Controlled Trial of Mild Hypothermia to Prevent Acute Kidney Injury in Liver Transplantation
UCSF REAC RAP Pilot for Junior InvestigatorsJan 1, 2019 - Dec 31, 2021
Role: Principal Investigator (Mentor: Claus Niemann)

Mild Hypothermia to prevent Acute kidney injury in Liver Transplantation (MHALT)
Department of Anesthesia & Perioperative Care Seed Support for Clinical ResearchAug 1, 2018 - Jul 31, 2019
Role: Prinicipal Investigator (Mentor: Claus Niemann)

ORNG Applications

Clinical Trials

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

The Yin and Yang of the Renin-Angiotensin-Aldosterone System in Acute Kidney Injury. Am J Respir Crit Care Med. 2021 05 01; 203(9):1053-1055. Legrand M, Bokoch MP. PMID: 33357099.

View in: PubMed Mentions: 1 Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans
The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation. Transplantation. 2020 11; 104(11):e308-e316. Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D. PMID: 32467477.

View in: PubMed Mentions: Fields:
Tra Transplantation
Translation:Humans
Pulmonary Hypertension and Mortality in Patients Awaiting Kidney Transplant: Cause for Concern and Potential Opportunity. Transplantation. 2020 10; 104(10):2001-2002. Bokoch MP, Findlay JY. PMID: 31929417.

View in: PubMed Mentions: Fields:
Tra Transplantation
Translation:Humans
Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Ann Intensive Care. 2020 Feb 12; 10(1):22. Khorashadi M, Bokoch MP, Legrand M. PMID: 32052208.

View in: PubMed Mentions:
Intravenous Fluid Management Practices in Kidney Transplant Patients: A Multicenter Observational Cohort Pilot Study. Semin Cardiothorac Vasc Anesth. 2020 Sep; 24(3):256-264. Efune GE, Zerillo J, Zhou G, Mazzeffi MA, Demaria S, Wang C, Society for the Advancement of Transplant Anesthesia Research Committee Writing Group . PMID: 31994444.

View in: PubMed Mentions: 1 Fields:
Ane Anesthesiology
Translation:Humans
Central Venous Catheter in the Internal Mammary Vein. Anesthesiology. 2019 Aug; 131(2):397. House LM, Yen A, Bokoch MP. PMID: 30973515.

View in: PubMed Mentions: 1 Fields:
Ane Anesthesiology
Translation:Humans
Management of Hyponatremia in End-Stage Liver Disease. Critical Care for Potential Liver Transplant Candidates. 2019 Jan 1; 69-88. Vanessa G. Henke, Michael P. Bokoch, Linda L. Liu. .

View in: Publisher Site Mentions:
Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Desmopressin Reverses Overly Rapid Serum Sodium Correction in a Hyponatremic Patient Undergoing Living Donor Liver Transplantation: A Case Report. A A Pract. 2018 Aug 01; 11(3):82-84. Brinson EL, Yu JS, Liu LL, Bokoch MP. PMID: 29634539.

View in: PubMed Mentions: Fields:
Ane Anesthesiology
Translation:Humans
Suppression of pupillary unrest by general anesthesia and propofol sedation. J Clin Monit Comput. 2019 Apr; 33(2):317-323. Behrends M, Larson MD, Neice AE, Bokoch MP. PMID: 29785552.

View in: PubMed Mentions: 5 Fields:
Med Medical Informatics Med Medicine (General)
Translation:Humans
Rapid Ventricular Pacing for Landing Zone Precision During Thoracic Endovascular Aortic Arch Repair: A Case Series. J Cardiothorac Vasc Anesth. 2017 12; 31(6):2141-2146. Bokoch MP, Hiramoto JS, Lobo EP, Shalabi A. PMID: 28764987.

View in: PubMed Mentions: Fields:
Ane Anesthesiology Car Cardiology Pul Pulmonary Medicine
Translation:Humans
Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest. Anesth Analg. 2017 03; 124(3):915-921. Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. PMID: 27941575.

View in: PubMed Mentions: 6 Fields:
Ane Anesthesiology
Translation:Humans
Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Auton Neurosci. 2015 May; 189:68-74. Bokoch MP, Behrends M, Neice A, Larson MD. PMID: 25737234.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Humans
Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule. Biophysical Journal. 2015 Jan 1; 108(2):350a. Michael P. Bokoch, Hyunil I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R. Coughlin. .

View in: Publisher Site Mentions:
From the journal archives: cyclopropane: induction and recovery with a bang! Can J Anaesth. 2014 Aug; 61(8):763-6. Bokoch MP, Gelb AW. PMID: 24421247.

View in: PubMed Mentions: Fields:
Ane Anesthesiology
Translation:Humans
The dynamic process of ß(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42. Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. PMID: 23374348.

View in: PubMed Mentions: 280 Fields:
Cel Cell Biology
Translation:Humans Cells
Lysine methylation strategies for characterizing protein conformations by NMR. J Biomol NMR. 2012 Oct; 54(2):199-209. Larda ST, Bokoch MP, Evanics F, Prosser RS. PMID: 22960995.

View in: PubMed Mentions: 12 Fields:
Mol Molecular Biology Nuc Nuclear Medicine
Translation:Cells
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature. 2010 Jan 07; 463(7277):108-12. Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK. PMID: 20054398.

View in: PubMed Mentions: 174 Fields:
Sci Science
Translation:Humans Cells
Conformational Changes in GPCR Surface and Core Probed by [13C]-Methyl NMR Spectroscopy. Biophysical Journal. 2010 Jan 1; 98(3):418a. Michael P. Bokoch, Rie Nygaard, Yaozhong Zou, Soren G.F. Rasmussen, Leonardo Pardo, R. Scott Prosser, Luciano Mueller, Brian K. Kobilka. .

View in: Publisher Site Mentions:
FRET-based measurement of GPCR conformational changes. Methods Mol Biol. 2009; 552:253-68. Granier S, Kim S, Fung JJ, Bokoch MP, Parnot C. PMID: 19513655.

View in: PubMed Mentions: 8 Fields:
Mol Molecular Biology
Translation:Humans Cells
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7682-7. Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK. PMID: 17452637.

View in: PubMed Mentions: 286 Fields:
Sci Science
Translation:Humans Animals Cells
Cytochrome c conformations resolved by the photon counting histogram: watching the alkaline transition with single-molecule sensitivity. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17570-5. Perroud TD, Bokoch MP, Zare RN. PMID: 16314563.

View in: PubMed Mentions: 13 Fields:
Sci Science
Translation:Animals Cells
Steady-state oxidation of cholesterol catalyzed by cholesterol oxidase in lipid bilayer membranes on platinum electrodes. Analytica Chimica Acta. 2004 Aug 1; 519(1):47-55. Michael P Bokoch, Anando Devadoss, Mariela S Palencsár, James D Burgess. .

View in: Publisher Site Mentions: