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Michael Bokoch, MD, PhD

Photo of Michael Bokoch, MD, PhD
Title(s)Associate Professor, Anesthesia
SchoolSchool of Medicine
Address521 Parnassus Avenue, #4231
San Francisco CA 94117
ORCID ORCID Icon0000-0003-1387-9547 Additional info
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    Collapse Biography 
    Collapse education and training
    UCSFFellowship2017Liver Transplant Anesthesia
    UCSFResidency2016Anesthesia
    Stanford University, Stanford, CAM.D.2011School of Medicine
    Stanford University, Stanford, CAPh.D.2010Biophysics
    Case Western Reserve University, Cleveland, OHB.S./B.A.2003Biology/Chemistry
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse awards and honors
    UCSF2023Short-Term Mentor Award (Summer Explore program)
    UCSF Anesthesia2023William K. Hamilton Award for Excellence in Resident Teaching
    UCSF Anesthesia2020William K. Hamilton Award for Excellence in Resident Teaching
    UCSF Anesthesia2019William K. Hamilton Award for Excellence in Resident Teaching
    UCSF Anesthesia2015Jeffrey A. Katz Award, for work ethic and professionalism in patient care
    UCSF2013Excellence in Medical Student Teaching Award
    Stanford University2011Allen B. Barbour Award, Excellence in Clinical Medicine
    Case Western Reserve University2003Phi Beta Kappa, Alpha of Ohio Chapter
    Case Western Reserve University2003John Schoff Millis Award, Senior with the best academic record
    Case Western Reserve University2003Mateescu Student Citizenship Award, Dept. of Chemistry
    Case Western Reserve University2003Daniel Burke Prize, Excellence in both Biology and Chemistry
    Case Western Reserve University2002Olin Freeman Tower Prize, Excellence in Physical Chemistry
    Case Western Reserve University2001Merck Index Award, Excellence in Chemistry
    Case Western Reserve University1999  - 2003Trustees' Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Angiotensin II in Liver Transplantation: a pilot randomized controlled trial
    UCSF Liver Center Pilot/Feasibility Grant for New Investigator NIH P30 DK026743Jun 1, 2021 - May 31, 2022
    Role: Principal Investigator
    Description: The goal of this single-center, randomized controlled, double-blind pilot trial is to assess the safety and efficacy of angiotensin II infusion versus placebo as a 2nd-line vasopressor for the treatment of hypotension during liver transplantation.
    Endothelial Activation by Liver Reperfusion Injury in Transplantation
    International Anesthesia Research Society IARS Mentored Research AwardJan 1, 2021 - Dec 31, 2023
    Role: Principal Investigator (Mentor: Judith Hellman)
    Description: The goal of this translational study is to determine possible mechanisms by which liver ischemia-reperfusion injury activates the vascular endothelium and leads to end-organ injury during liver transplantation.
    Early Detection of Acute Kidney Injury (AKI) by NephroCheck® in the MHALT Trial
    BioMérieux, Inc. Investigator Initiated Research collaborationMar 11, 2020 - Dec 31, 2021
    Role: Principal Investigator (Mentor: Matthieu Legrand)
    A Randomized Controlled Trial of Mild Hypothermia to Prevent Acute Kidney Injury in Liver Transplantation
    UCSF REAC RAP Pilot for Junior InvestigatorsJan 1, 2019 - Dec 31, 2021
    Role: Principal Investigator (Mentor: Claus Niemann)
    Mild Hypothermia to prevent Acute kidney injury in Liver Transplantation (MHALT)
    Department of Anesthesia & Perioperative Care Seed Support for Clinical ResearchAug 1, 2018 - Jul 31, 2019
    Role: Prinicipal Investigator (Mentor: Claus Niemann)

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microbial and host inflammatory factors induce permeability and activate cytokine production by human glomerular microvascular endothelial cells. Shock. 2025 Sep 12. Zhuang C, Xu F, Tsutsui K, Bokoch MP, Hellman J. PMID: 40961371.
      View in: PubMed   Mentions:    Fields:    
    2. High body mass index at liver transplantation: A retrospective single-center analysis of blood product utilization and postoperative outcomes. Am J Transplant. 2025 Aug 27. Zeiner S, Kothari RP, Reddy M, Mendez NV, Roll GR, Braun HJ, Bokoch MP, Kolodzie K, Kimberger O, Legrand M, Adelmann D. PMID: 40882844.
      View in: PubMed   Mentions:    Fields:    
    3. Ultrasound-based assessment of muscle mass is associated with early recovery after kidney transplant: a prospective single-center study. BMC Anesthesiol. 2025 Aug 26; 25(1):424. Mendez NV, Bokoch MP, Adelmann D, Bucknor MD, Ku E, Kolodzie K. PMID: 40859136; PMCID: PMC12379526.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Local adoption of norepinephrine as the first-line vasopressor in major noncardiac surgery: impact of a pragmatic clinical trial on real-world practice. Br J Anaesth. 2025 Oct; 135(4):1078-1080. Ansay C, Chawla SA, Fong N, Lin R, Chang JM, Whitlock EL, Kothari RP, Legrand M, Bokoch MP. PMID: 40819974.
      View in: PubMed   Mentions:    Fields:    
    5. Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis. Transplant Direct. 2025 Jun; 11(6):e1814. Antonucci E, Bokoch MP, Adelmann D, Kolodzie K, Roll GR, Sun E, Legrand M, Kothari R. PMID: 40406183; PMCID: PMC12097770.
      View in: PubMed   Mentions:
    6. Safety and Feasibility of Early Extubation in Liver Transplantation: Experience in 1555 Patients. Transplantation. 2025 08 01; 109(8):1393-1401. Lacom C, Kothari RP, Mendez NV, Galli A, Roll GR, Bokoch MP, Legrand M, Adelmann D. PMID: 39948722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Postoperative Delirium in a Randomized Trial of Intraoperative Norepinephrine versus Phenylephrine Infusion. Anesthesiology. 2025 Jan 01; 142(1):234-237. Phero A, Bokoch MP, Kothari R, Fong N, Chen D, Pirracchio R, Legrand M, Whitlock EL. PMID: 39655990.
      View in: PubMed   Mentions:    Fields:    
    8. Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo. Front Med (Lausanne). 2024; 11:1412891. Bokoch MP, Xu F, Govindaraju K, Lloyd E, Tsutsui K, Kothari RP, Adelmann D, Joffre J, Hellman J. PMID: 39021821; PMCID: PMC11252006.
      View in: PubMed   Mentions:
    9. Current Anesthesiology Reports. Goal-Directed Therapy in Liver Surgery. 2024; 1-12. Marcus, SG Syed, S Anderson, AL Bokoch, MP. View Publication.
    10. Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial. Br J Anaesth. 2024 Apr; 132(4):685-694. Krone S, Bokoch MP, Kothari R, Fong N, Tallarico RT, Sturgess-DaPrato J, Pirracchio R, Zarbock A, Legrand M. PMID: 38242802.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Mismatched Postsurgical Opioid Prescription to Liver Transplant Patients: A Retrospective Cohort Study From a Single High-volume Transplant Center. Transplantation. 2024 02 01; 108(2):483-490. Chen VJ, Guan LS, Bokoch MP, Langnas E, Kothari R, Croci R, Campbell LJ, Quan D, Freise C, Guan Z. PMID: 38259180.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial. BMJ Open. 2023 11 19; 13(11):e078713. Bokoch MP, Tran AT, Brinson EL, Marcus SG, Reddy M, Sun E, Roll GR, Pardo M, Fields S, Adelmann D, Kothari RP, Legrand M. PMID: 37984940; PMCID: PMC10660907.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    13. Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle? Clin Transplant. 2023 10; 37(10):e15057. Galli AM, Kothari R, Adelmann D, Holm Z, Bokoch MP, De Gasperi A, Niemann CU, Kolodzie K. PMID: 37350743.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Real-world implementation of normothermic machine perfusion: A detailed analysis of intraoperative and early postoperative impact. Clin Transplant. 2023 10; 37(10):e15049. Dixon W, Sheetz K, Adelmann D, Bokoch M, Reddy M, Kothari R, Roberts JP, Syed S, Feng S, Roll G. PMID: 37329290.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Pulmonary Injury Causing a Massive Air Leak During Liver Transplantation: A Case Report and Discussion of Decision-Making. A A Pract. 2023 Jun 01; 17(6):e01694. Mavrothalassitis O, Marcus SG, Roll GR, Tallarico RT, Bokoch MP. PMID: 37335882.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial. Br J Anaesth. 2023 05; 130(5):519-527. Legrand M, Kothari R, Fong N, Palaniappa N, Boldt D, Chen LL, Kurien P, Gabel E, Sturgess-DaPrato J, Harhay MO, Pirracchio R, Bokoch MP, VEGA-1 trial investigators. PMID: 36925330.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes. Ann Surg. 2023 10 01; 278(4):e745-e753. Lazzareschi DV, Fong N, Mavrothalassitis O, Whitlock EL, Chen CL, Chiu C, Adelmann D, Bokoch MP, Chen LL, Liu KD, Pirracchio R, Mathis MR, Legrand M, MPOG Collaborators. PMID: 36521076; PMCID: PMC10481928.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Prepectoral Breast Reconstruction Reduces Opioid Consumption and Pain After Mastectomy: A Head-to-Head Comparison With Submuscular Reconstruction. Ann Plast Surg. 2022 11 01; 89(5):492-499. Holland M, Su P, Piper M, Withers J, Harbell MW, Bokoch MP, Sbitany H. PMID: 36279573.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    19. Optimizing the Design and Analysis of Future AKI Trials. J Am Soc Nephrol. 2022 08; 33(8):1459-1470. Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO. PMID: 35831022; PMCID: PMC9342638.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. The Yin and Yang of the Renin-Angiotensin-Aldosterone System in Acute Kidney Injury. Am J Respir Crit Care Med. 2021 05 01; 203(9):1053-1055. Legrand M, Bokoch MP. PMID: 33357099; PMCID: PMC8314897.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    21. The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation. Transplantation. 2020 11; 104(11):e308-e316. Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D. PMID: 32467477.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Pulmonary Hypertension and Mortality in Patients Awaiting Kidney Transplant: Cause for Concern and Potential Opportunity. Transplantation. 2020 10; 104(10):2001-2002. Bokoch MP, Findlay JY. PMID: 31929417.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery? Ann Intensive Care. 2020 Feb 12; 10(1):22. Khorashadi M, Bokoch MP, Legrand M. PMID: 32052208; PMCID: PMC7016086.
      View in: PubMed   Mentions: 3  
    24. Intravenous Fluid Management Practices in Kidney Transplant Patients: A Multicenter Observational Cohort Pilot Study. Semin Cardiothorac Vasc Anesth. 2020 Sep; 24(3):256-264. Efune GE, Zerillo J, Zhou G, Mazzeffi MA, Demaria S, Wang C, Society for the Advancement of Transplant Anesthesia Research Committee Writing Group. PMID: 31994444.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Central Venous Catheter in the Internal Mammary Vein. Anesthesiology. 2019 Aug; 131(2):397. House LM, Yen A, Bokoch MP. PMID: 30973515.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Management of Hyponatremia in End-Stage Liver Disease. Critical Care for Potential Liver Transplant Candidates. 2019 Jan 1; 69-88. Henke HV, Bokoch BM, Liu LL. .
      View in: Publisher Site   Mentions:
    27. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523; PMCID: PMC6584023.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Desmopressin Reverses Overly Rapid Serum Sodium Correction in a Hyponatremic Patient Undergoing Living Donor Liver Transplantation: A Case Report. A A Pract. 2018 Aug 01; 11(3):82-84. Brinson EL, Yu JS, Liu LL, Bokoch MP. PMID: 29634539.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Suppression of pupillary unrest by general anesthesia and propofol sedation. J Clin Monit Comput. 2019 Apr; 33(2):317-323. Behrends M, Larson MD, Neice AE, Bokoch MP. PMID: 29785552.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    30. Rapid Ventricular Pacing for Landing Zone Precision During Thoracic Endovascular Aortic Arch Repair: A Case Series. J Cardiothorac Vasc Anesth. 2017 12; 31(6):2141-2146. Bokoch MP, Hiramoto JS, Lobo EP, Shalabi A. PMID: 28764987.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest. Anesth Analg. 2017 03; 124(3):915-921. Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. PMID: 27941575.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    32. Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Auton Neurosci. 2015 May; 189:68-74. Bokoch MP, Behrends M, Neice A, Larson MD. PMID: 25737234.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    33. From the journal archives: cyclopropane: induction and recovery with a bang! Can J Anaesth. 2014 Aug; 61(8):763-6. Bokoch MP, Gelb AW. PMID: 24421247.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. The dynamic process of β(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42. Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. PMID: 23374348; PMCID: PMC3586676.
      View in: PubMed   Mentions: 402     Fields:    Translation:HumansCells
    35. Lysine methylation strategies for characterizing protein conformations by NMR. J Biomol NMR. 2012 Oct; 54(2):199-209. Larda ST, Bokoch MP, Evanics F, Prosser RS. PMID: 22960995.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    36. Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature. 2010 Jan 07; 463(7277):108-12. Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK. PMID: 20054398; PMCID: PMC2805469.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansCells
    37. FRET-based measurement of GPCR conformational changes. Methods Mol Biol. 2009; 552:253-68. Granier S, Kim S, Fung JJ, Bokoch MP, Parnot C. PMID: 19513655.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    38. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7682-7. Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK. PMID: 17452637; PMCID: PMC1863461.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansAnimalsCells
    39. Cytochrome c conformations resolved by the photon counting histogram: watching the alkaline transition with single-molecule sensitivity. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17570-5. Perroud TD, Bokoch MP, Zare RN. PMID: 16314563; PMCID: PMC1308922.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    40. Steady-state oxidation of cholesterol catalyzed by cholesterol oxidase in lipid bilayer membranes on platinum electrodes. Analytica Chimica Acta. 2004 Aug 1; 519(1):47-55. Bokoch BM, Devadoss DA, Palencsár PM, Burgess BJ. .
      View in: Publisher Site   Mentions:
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