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A Physiologically-Based Pharmacokinetic Simulation to Evaluate Approaches to Mitigate Efavirenz-Induced Decrease in Levonorgestrel Exposure with a Contraceptive Implant. Pharmaceutics. 2024 Aug 07; 16(8).
Adeojo LW, Patel RC, Sambol NC. PMID: 39204395; PMCID: PMC11359785.
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Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. PLoS Med. 2017 01; 14(1):e1002212.
Hoglund RM, Workman L, Edstein MD, Thanh NX, Quang NN, Zongo I, Ouedraogo JB, Borrmann S, Mwai L, Nsanzabana C, Price RN, Dahal P, Sambol NC, Parikh S, Nosten F, Ashley EA, Phyo AP, Lwin KM, McGready R, Day NP, Guerin PJ, White NJ, Barnes KI, Tarning J. PMID: 28072872; PMCID: PMC5224788.
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PubMed Mentions:
38 Fields:
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HumansAnimals
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Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria. J Infect Dis. 2016 Oct 15; 214(8):1243-51.
Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S. PMID: 27471317; PMCID: PMC5034953.
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10 Fields:
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HumansAnimals
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Rethinking Dosing Regimen Selection of Piperaquine for Malaria Chemoprevention: A Simulation Study. PLoS One. 2016; 11(5):e0154623.
Sambol NC, Tappero JW, Arinaitwe E, Parikh S. PMID: 27182702; PMCID: PMC4868321.
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6 Fields:
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Humans
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Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria. Clin Pharmacol Ther. 2015 Jul; 98(1):87-95.
Sambol NC, Yan L, Creek DJ, McCormack SA, Arinaitwe E, Bigira V, Wanzira H, Kakuru A, Tappero JW, Lindegardh N, Tarning J, Nosten F, Aweeka FT, Parikh S. PMID: 25732044; PMCID: PMC5088713.
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9 Fields:
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Humans
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CYP2A6 genotype but not age determines cotinine half-life in infants and children. Clin Pharmacol Ther. 2013 Sep; 94(3):400-6.
Dempsey DA, Sambol NC, Jacob P, Hoffmann E, Tyndale RF, Fuentes-Afflick E, Benowitz NL. PMID: 23714690; PMCID: PMC3820275.
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17 Fields:
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HumansPHPublic Health
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Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity. Surg Obes Relat Dis. 2008 Sep-Oct; 4(5):625-31.
Borkgren-Okonek MJ, Hart RW, Pantano JE, Rantis PC, Guske PJ, Kane JM, Gordon N, Sambol NC. PMID: 18261965.
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45 Fields:
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Humans
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Pharmacokinetics of single-dose levonorgestrel in adolescents. Contraception. 2006 Aug; 74(2):104-9.
Sambol NC, Harper CC, Kim L, Liu CY, Darney P, Raine TR. PMID: 16860047.
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4 Fields:
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HumansCTClinical Trials
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Plasma pharmacokinetics and tissue biodistribution of boron following administration of a boronated porphyrin in dogs. J Pharm Sci. 2000 Apr; 89(4):469-77.
Tibbitts J, Sambol NC, Fike JR, Bauer WF, Kahl SB. PMID: 10737908.
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PubMed Mentions:
4 Fields:
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Animals
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Pharmacodynamic analysis of analgesic clinical trials: nonlinear mixed-effects logistic models. J Biopharm Stat. 1999 May; 9(2):253-70.
Liu CY, Sambol NC. PMID: 10379692.
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1 Fields:
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Humans
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Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. J Clin Pharmacol. 1996 Nov; 36(11):1012-21.
Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. PMID: 8973990.
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49 Fields:
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HumansCTClinical Trials
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In vitro-in vivo relationship of oral extended-release dosage forms. Pharm Res. 1996 Oct; 13(10):1501-6.
Liu FY, Sambol NC, Giannini RP, Liu CY. PMID: 8899841.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. Br J Clin Pharmacol. 1996 Oct; 42(4):510-2.
Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. PMID: 8904626.
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23 Fields:
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HumansCTClinical Trials
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Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol. 1995 Nov; 35(11):1094-102.
Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. PMID: 8626883.
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43 Fields:
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Humans
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Felodipine population dose-response and concentration-response relationships in patients with essential hypertension. Clin Pharmacol Ther. 1995 May; 57(5):569-81.
Wade JR, Sambol NC. PMID: 7768080.
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PubMed Mentions:
8 Fields:
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HumansCTClinical Trials
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Pharmacokinetics of oral extended-release dosage forms. I. Release kinetics, concentration, and absorbed fraction. Pharm Res. 1995 May; 12(5):720-8.
Liu FY, Sambol NC, Giannini RP, Liu CY. PMID: 7479559.
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2 Fields:
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Cells
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Pharmacodynamic analysis of analgesic clinical trials using empirical methods. Pharm Res. 1995 Mar; 12(3):438-45.
Liu CY, Sambol NC. PMID: 7617534.
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1 Fields:
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Humans
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Interaction between structural, statistical, and covariate models in population pharmacokinetic analysis. J Pharmacokinet Biopharm. 1994 Apr; 22(2):165-77.
Wade JR, Beal SL, Sambol NC. PMID: 7815312.
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25 Fields:
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Humans
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Variational analysis of the transdermal delivery rate from two prototypical ethanol-water nitroglycerin TTS devices and Transderm-Nitro 10 in the normal population. J Pharmacokinet Biopharm. 1992 Oct; 20(5):443-59.
Kochak GM, Berner B, Leal M, Sambol NC. PMID: 1287196.
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1 Fields:
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HumansCTClinical Trials
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Population dose versus response of betaxolol and atenolol: a comparison of potency and variability. Clin Pharmacol Ther. 1991 Jan; 49(1):24-31.
Sambol NC, Sheiner LB. PMID: 1988237.
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5 Fields:
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HumansCTClinical Trials
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Effect of hydrochlorothiazide 25 mg/day on essential hypertension. Clin Pharm. 1990 Nov; 9(11):873-5.
Sambol NC, Bostrom A, Williams RL. PMID: 2272153.
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HumansCTClinical Trials
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Pharmacokinetics, pharmacodynamics, and minimum effective clinical dose of intravenous nicardipine. Clin Pharmacol Ther. 1990 Jun; 47(6):706-18.
Cook E, Clifton GG, Vargas R, Bienvenu G, Williams R, Sambol N, McMahon G, Grandy S, Lai CM, Quon C, et al. PMID: 2357865.
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7 Fields:
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HumansCTClinical Trials
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Study designs for dose-ranging. Clin Pharmacol Ther. 1989 Jul; 46(1):63-77.
Sheiner LB, Beal SL, Sambol NC. PMID: 2743708.
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28 Fields:
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Humans
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A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow. Br J Clin Pharmacol. 1989 Jan; 27(1):83-7.
Sambol NC, Upton RA, Chremos AN, Lin ET, Williams RL. PMID: 2565119; PMCID: PMC1379708.
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4 Fields:
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HumansCTClinical Trials
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Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response. Cancer Res. 1985 Jul; 45(7):3354-8.
Benz C, DeGregorio M, Saks S, Sambol N, Holleran W, Ignoffo R, Lewis B, Cadman E. PMID: 4005858.
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PubMed Mentions:
3 Fields:
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Humans