Dr. Fuentes-Afflick has been a UCSF faculty member since 1993. She is Professor and Vice Chair of Pediatrics, Chief of Pediatrics at the Zuckerberg San Francisco General Hospital, and Vice Dean for Academic Affairs in the School of Medicine.

As a pediatrician and epidemiologist, Dr. Fuentes-Afflick has conducted research studies focused on issues of acculturation, immigrant health, and health disparities. Her scholarship has also focused on the importance of diversity in academic medicine and academic pediatrics.

After completing her undergraduate and medical education in the Inteflex Program at the University of Michigan, Dr. Fuentes-Afflick came to UCSF for her residency training in pediatrics, followed by a fellowship in health policy at UCSF and MPH in epidemiology from UC Berkeley. She has served in several important national leadership roles, including President of the Society for Pediatric Research, President of the American Pediatric Society, and service on the Council of the National Institute for Child Health and Development. Dr. Fuentes-Afflick was chair of the UCSF Academic Senate from 2009-2011. She was elected to the National Academy of Medicine in 2010 and elected to membership n the American Academy of Arts and Sciences in 2020.

In 2012, Dr. Fuentes-Afflick was appointed Vice Dean for Academic Affairs and Faculty Development for the School of Medicine. She is responsible for overseeing all academic affairs in the School of Medicine, including the recruitment, development and advancement of a diversified academic workforce of the highest caliber. She is also responsible for overseeing innovative programs for faculty orientation, career development, and leadership training.