P. Daniel Knott, MD

Title(s)Professor, Otolaryngology
SchoolSchool of Medicine
Address2233 Post Street, #361
San Francisco CA 94115
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    Collapse Biography 
    Collapse Education and Training
    University of California San DiegoM.D.2000School of Medicine
    Collapse Awards and Honors
    American Head and Neck Society2006  - 2007Robert Maxwell Byers Award
    American Academy of Facial Plastic and Reconstructive Surgery2007  - 2008Ben Shuster Memorial Award
    American Academy of Facial Plastic and Reconstructive Surgery2008  - 2009Ira Tresley Research Award
    UCSF Department of Otolaryngology/Head and Neck Surgery2011  - 2012Roger Boles Teaching Award
    UCSF Medical Center2012  - 2013Kaiser Teacher of the Year Award-Inpatient Care

    Collapse Overview 
    Collapse Overview
    P. Daniel Knott, MD, is a Professor in the Facial Plastic, Aesthetic and Reconstructive Surgery Division, and he is the Director of Facial Plastic and Aesthetic Surgery in Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. Dr. Knott received his medical degree from the University of California, San Diego in La Jolla. He completed a one-year General Surgery internship from the Cleveland Clinic in Ohio, and a five-year OHNS residency from the same institution, followed by a Facial Plastic and Reconstructive Surgery fellowship from the University of California, Los Angeles Medical Center.

    Dr. Knott particularly specializes in artificial tissue and tissue engineering applications. He has extensive experience on the full spectrum of facial anesthetic operations and treatments, with great focus of the reconstruction of traumatic, malignant, and congenital defects of the head and neck. He also has experience in creating solutions for the two common issues that affect the face over time - treating the descent of the soft tissues and facial soft tissue atrophy.

    Dr. Knott’s clinical research has focused on the novel applications, morbidities, and recipient potential of the antero-lateral thigh free flap. He has been using free flap in many innovative ways including, pharyngeal, nasal, scalp, and mid-facial reconstruction. Dr. Knott continues his research efforts in the basic science sphere, which focuses on the broad concept of cartilage bioengineering. Along with cross-sectional colleagues, Dr. Knott has patented a technique of cross-linking collagen and hyaluronic acid using a tyramine-based chemical process. The cross-linking can be performed across a wide spectrum of concentrations, yielding a variety of biomaterials of differing strengths, shear resistances, and biomechanical properties.

    Dr. Knott has authored over 30 peer-reviewed papers and serves as a peer reviewer on topics related to facial plastic and reconstructive surgery for multiple national journals including, Head and Neck Surgery, JAMA Facial Plastic Surgery, Laryngoscope, the International Journal of Dermatology, and Otolaryngology-Head and Neck Surgery. Dr. Knott has authored six book chapters on facial aesthetic surgery and published a book on the aesthetic use of botox.

    Facial Plastic, Aesthetic and Reconstructive Surgery

    Rhinoplasty, treatment of facial aging, treatment of facial paralysis, reconstruction of facial cutaneous malignancies, and free tissue transfer

    Professional Interests:
    Facial paralysis, microvascular facial reconstruction, free tissue transfer, maxillary reconstruction

    Education and Training:
    • Medical School: University of California, San Diego, La Jolla
    • Internship: Cleveland Clinic, OH – General Surgery
    • Residency: Cleveland Clinic, OH – Otolaryngology – Head and Neck Surgery
    • Fellowship: University of California, Los Angeles Medical Center– Facial Plastic and Reconstructive Surgery
    • Medical Licensure, California
    • Medical Licensure, Ohio
    • Board Certification, Otolaryngology - Head and Neck Surgery
    • Board Certification, Facial Plastic and Reconstructive Surgery

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    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatitis C as a Potential Risk Factor for Adverse Surgical Outcomes in Head and Neck Free Tissue Transfer Reconstruction. Facial Plast Surg Aesthet Med. 2022 Jul-Aug; 24(4):300-304. Callander JK, Strohl MP, Knott PD, Park A, Seth R, Heaton CM. PMID: 34449263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Hyperostotic esthesioneuroblastoma: rare variant and fibrous dysplasia mimicker. Korean J Radiol. 2014 Jan-Feb; 15(1):156-60. Ahmed M, Knott PD. PMID: 24497807; PMCID: PMC3909850.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Motor nerve to the vastus lateralis. Arch Facial Plast Surg. 2012 Sep-Oct; 14(5):365-8. Revenaugh PC, Knott D, McBride JM, Fritz MA. PMID: 22508894.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    4. Simultaneous anterolateral thigh flap and temporalis tendon transfer to optimize facial form and function after radical parotidectomy. Arch Facial Plast Surg. 2012 Mar-Apr; 14(2):104-9. Revenaugh PC, Knott PD, Scharpf J, Fritz MA. PMID: 22431814.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    5. Orbitomaxillary reconstruction using the layered fibula osteocutaneous flap. Arch Facial Plast Surg. 2012 Mar-Apr; 14(2):110-5. Shipchandler TZ, Waters HH, Knott PD, Fritz MA. PMID: 22431815.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    6. A 12-year perspective on the world's first total laryngeal transplant. Transplantation. 2011 Apr 15; 91(7):804-5. Knott PD, Hicks D, Braun W, Strome M. PMID: 21436654.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Volume-directed facial soft tissue deficit reconstruction. Facial Plast Surg. 2010 Dec; 26(6):494-503. Seth R, Nabili V, Fritz MA, Alam DS, Knott PD. PMID: 21086236.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Outcomes of vascularized bone graft reconstruction of the mandible in bisphosphonate-related osteonecrosis of the jaws. Laryngoscope. 2010 Nov; 120(11):2165-71. Seth R, Futran ND, Alam DS, Knott PD. PMID: 20824743.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    9. Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. Am J Otolaryngol. 2011 Nov-Dec; 32(6):464-9. Revenaugh PC, Seth R, Pavlovich JB, Knott PD, Batra PS. PMID: 21041001.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    10. Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. Am J Otolaryngol. 2011 Sep-Oct; 32(5):433-7. Makin V, Hatipoglu B, Hamrahian AH, Arrossi AV, Knott PD, Lee JH, Sade B. PMID: 20888068.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Vascularized bone graft reconstruction of the temporomandibular joint using the tunneled, anchored suture technique. Laryngoscope. 2010; 120 Suppl 4:S236. Seth R, Waters HH, Knott PD. PMID: 21225834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. A novel bioabsorbable device for facial suspension and rejuvenation. Arch Facial Plast Surg. 2009 Mar-Apr; 11(2):129-35. Knott PD, Newman J, Keller GS, Apfelberg DB. PMID: 19289687.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Induction with T-cell receptor antibody leads to long-term laryngeal allograft function. Am J Otolaryngol. 2008 Nov-Dec; 29(6):398-402. Knott PD, Dan O, Strome M. PMID: 19144301.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    14. Advanced lip reconstruction: functional and aesthetic considerations. Facial Plast Surg. 2008 Jan; 24(1):92-104. Nabili V, Knott PD. PMID: 18286438.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Evaluation of hardware-related complications in vascularized bone grafts with locking mandibular reconstruction plate fixation. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12):1302-6. Knott PD, Suh JD, Nabili V, Sercarz JA, Head C, Abemayor E, Blackwell KE. PMID: 18086976.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. RAD inhibition of sarcoma growth: implications for laryngeal transplantation. Am J Otolaryngol. 2007 Nov-Dec; 28(6):375-8. Knott PD, Tamai H, Strome M, Van Lente F, Shu S. PMID: 17980767.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. A comparison of dermabond tissue adhesive and sutures in the primary repair of the congenital cleft lip. Ann Plast Surg. 2007 Feb; 58(2):121-5. Knott PD, Zins JE, Banbury J, Djohan R, Yetman RJ, Papay F. PMID: 17245135.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Vocal outcomes after laser resection of early-stage glottic cancer with adjuvant cryotherapy. Arch Otolaryngol Head Neck Surg. 2006 Nov; 132(11):1226-30. Knott PD, Milstein CF, Hicks DM, Abelson TI, Byrd MC, Strome M. PMID: 17116819.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Contour and paired-point registration in a model for image-guided surgery. Laryngoscope. 2006 Oct; 116(10):1877-81. Knott PD, Batra PS, Butler RS, Citardi MJ. PMID: 17003709.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    20. Vocal fold healing after laser cordectomy with adjuvant cryotherapy. Laryngoscope. 2006 Sep; 116(9):1580-4. Knott PD, Byrd MC, Hicks DG, Strome M. PMID: 16954983.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    21. Computer aided surgery: concepts and applications in rhinology. Otolaryngol Clin North Am. 2006 Jun; 39(3):503-22, ix. Knott PD, Batra PS, Citardi MJ. PMID: 16757228.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Pulsed immunosuppression with everolimus and anti-alphabeta T-cell receptor: laryngeal allograft preservation at six months. Ann Otol Rhinol Laryngol. 2006 Jan; 115(1):74-80. Khariwala SS, Knott PD, Dan O, Klimczak A, Siemionow M, Strome M. PMID: 16466103.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Hemophilia B and free tissue transfer: medical and surgical management. Ann Plast Surg. 2005 Mar; 54(3):336-8. Knott PD, Khariwala SS, Minarchek J. PMID: 15725848.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. High-frequency ultrasound in the measurement of pediatric craniofacial integrity. Otolaryngol Head Neck Surg. 2004 Dec; 131(6):851-5. Knott PD, Hazony D, Karafa M, Koltai PJ. PMID: 15577779.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. The impact of fiducial distribution on headset-based registration in image-guided sinus surgery. Otolaryngol Head Neck Surg. 2004 Nov; 131(5):666-72. Knott PD, Maurer CR, Gallivan R, Roh HJ, Citardi MJ. PMID: 15523446.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    26. Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children. Arch Otolaryngol Head Neck Surg. 2003 Aug; 129(8):841-6. Akst LM, Lee W, Discolo C, Knott D, Younes A, Koltai PJ. PMID: 12925342.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. Laryngoscope. 2003 May; 113(5):783-90. Knott PD, Gannon FH, Thompson LD. PMID: 12792311.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    28. Sensorineural hearing loss and Kawasaki disease: a prospective study. Am J Otolaryngol. 2001 Sep-Oct; 22(5):343-8. Knott PD, Orloff LA, Harris JP, Novak RE, Burns JC, Kawasaki Disease Multicenter Hearing Loss Study Group. PMID: 11562886.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
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