Tamara Alliston, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1155
San Francisco CA 94143
Phone415-502-6523
PronounsShe/Her/Hers
ORCID ORCID Icon0000-0001-9992-2897 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Trinity University, San Antonio, TXB.A.Biology
    Baylor College of Medicine, Houston, TXPhDCell Biology
    University of California San Francisco, San Francisco, CAPost-docCell and Tissue Biology

    Collapse Overview 
    Collapse Overview
    Our research focuses on the mechanobiologic pathways controlling stem cell and skeletal cell differentiation in bone and cartilage. We seek to understand how these pathways maintain the mechanical integrity of the healthy skeleton, and how this is disrupted in skeletal diseases like arthritis and osteoporosis.

    In particular, we study the mechanobiology of TGFβ in the skeleton. To answer these questions we combine molecular, cellular, physiologic, bioengineering, and materials science approaches. This interdisciplinary approach will advance the development of therapies that can prevent skeletal disease and improve the speed and success of skeletal tissue regeneration.

    Collapse Research 
    Collapse Research Activities and Funding
    Core Center for Musculoskeletal Biology and Medicine (Overall Application)
    NIH P30AR075055Jul 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    2018 Musculoskeletal Biology and Bioengineering Gordon Research Conference and Gordon Research Seminar
    NIH R13AR073652Mar 23, 2018 - Feb 28, 2019
    Role: Principal Investigator
    miRNA coordination of TGF-beta / Wnt signaling in osteocyte mechanotransduction
    NIH R21AR070403Aug 1, 2017 - Jul 31, 2020
    Role: Principal Investigator
    AAOS/ORS Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone Research Symposium
    NIH R13AR068913Sep 21, 2015 - Aug 31, 2016
    Role: Principal Investigator
    The mechanobiology of TGF-beta signaling in chondrocytes
    NIH R21AR067439Sep 18, 2014 - Aug 31, 2017
    Role: Principal Investigator
    The mechanistic control of bone quality and joint crosstalk by osteocytes
    NIH R01DE019284Jul 1, 2008 - May 31, 2025
    Role: Principal Investigator
    TGF-Beta regulation of Runx2 in bone formation and quality
    NIH R03DE016868Mar 1, 2006 - Feb 28, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease. JCI Insight. 2024 Nov 08; 9(21). Sato AY, Cregor M, McAndrews K, Schurman CA, Schaible E, Shutter J, Vyas P, Adhikari B, Willis MS, Boerma M, Alliston T, Bellido T. PMID: 39405125; PMCID: PMC11601705.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling. Matrix Biol. 2024 Nov; 133:1-13. Labelle-Dumais C, Mazur C, Kaya S, Obata Y, Lee B, Acevedo C, Alliston T, Gould DB. PMID: 39097038.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Mass Spectrometry Imaging of the Subchondral Bone in Osteoarthritis Reveals Tissue Remodeling of Extracellular Matrix Proteins that Precede Cartilage Loss. bioRxiv. 2024 Aug 05. Schurman CA, Bons J, Woo JJ, Yee C, Tao N, Alliston T, Angel PM, Schilling B. PMID: 39211075; PMCID: PMC11361078.
      View in: PubMed   Mentions:
    4. The osteocytic actions of glucocorticoids on bone mass, mechanical properties, or perilacunar remodeling outcomes are not rescued by PTH(1-34). Front Endocrinol (Lausanne). 2024; 15:1342938. Yee CS, Meliadis C, Kaya S, Chang W, Alliston T. PMID: 39092287; PMCID: PMC11291448.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. High-fat and high-carbohydrate diets increase bone fragility through TGF-β-dependent control of osteocyte function. JCI Insight. 2024 Jul 09; 9(16). Dole NS, Betancourt-Torres A, Kaya S, Obata Y, Schurman CA, Yoon J, Yee CS, Khanal V, Luna CA, Carroll M, Salinas JJ, Miclau E, Acevedo C, Alliston T. PMID: 39171528; PMCID: PMC11343608.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Spatial control of perilacunar canalicular remodeling during lactation. Sci Rep. 2024 06 25; 14(1):14655. Sieverts M, Yee C, Nemani M, Parkinson DY, Alliston T, Acevedo C. PMID: 38918485; PMCID: PMC11199490.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Effect of Passaging on Bovine Chondrocyte Gene Expression and Engineered Cartilage Production. Tissue Eng Part A. 2024 Sep; 30(17-18):512-524. Lindberg ED, Kaya S, Jamali AA, Alliston T, O'Connell GD. PMID: 38323585.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Aging impairs the osteocytic regulation of collagen integrity and bone quality. Bone Res. 2024 02 26; 12(1):13. Schurman CA, Kaya S, Dole N, Luna NMM, Castillo N, Potter R, Rose JP, Bons J, King CD, Burton JB, Schilling B, Melov S, Tang S, Schaible E, Alliston T. PMID: 38409111; PMCID: PMC10897167.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Abstract C036: Restoration of T effector cells function by targeting senescent cancer-associated fibroblast in tumor microenvironment of stroma-rich cancers. Cancer Research. 2024 Jan 16; 84(2_Supplement):c036-c036. Wang WY, Apostolopoulou AH, Sanyal SA, Sun SH, Sieland SC, Gupta GK, Ye YJ, Gibbs GD, Wong WP, Vasilis VN, Huang HS, Gardner GJ, Maker MA, Tlsty TT, Bhushan BA, Alliston AT. .
      View in: Publisher Site   Mentions:
    10. Priming chondrocytes during expansion alters cell behavior and improves matrix production in 3D culture. Osteoarthritis Cartilage. 2024 May; 32(5):548-560. Lindberg ED, Wu T, Cotner KL, Glazer A, Jamali AA, Sohn LL, Alliston T, O'Connell GD. PMID: 38160742.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Deep learning models to map osteocyte networks can successfully distinguish between young and aged bone. bioRxiv. 2023 Dec 21. Vetter SD, Schurman CA, Alliston T, Slabaugh GG, Verbruggen SW. PMID: 38187546; PMCID: PMC10769292.
      View in: PubMed   Mentions:
    12. Type 2 diabetes impairs annulus fibrosus fiber deformation and rotation under disc compression in the University of California Davis type 2 diabetes mellitus (UCD-T2DM) rat model. PNAS Nexus. 2023 Dec; 2(12):pgad363. Rosenberg JL, Schaible E, Bostrom A, Lazar AA, Graham JL, Stanhope KL, Ritchie RO, Alliston TN, Lotz JC, Havel PJ, Acevedo C, Fields AJ. PMID: 38094616; PMCID: PMC10718642.
      View in: PubMed   Mentions: 2  
    13. Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research. Curr Osteoporos Rep. 2023 12; 21(6):637-649. Kaya S, Alliston T, Evans DS. PMID: 37831357; PMCID: PMC11098148.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease. PLoS One. 2023; 18(10):e0292268. Rose JP, Schurman CA, King CD, Bons J, Patel SK, Burton JB, O'Broin A, Alliston T, Schilling B. PMID: 37816044; PMCID: PMC10564166.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium. J Gerontol A Biol Sci Med Sci. 2023 10 09; 78(10):1733-1739. Zhang X, Tyrrell DJ, Alliston T, Schilling B, Yousefzadeh MJ, Schafer MJ. PMID: 37148367; PMCID: PMC10562889.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. miR181a/b-1 controls osteocyte metabolism and mechanical properties independently of bone morphology. Bone. 2023 10; 175:116836. Yoon J, Kaya S, Matsumae G, Dole N, Alliston T. PMID: 37414200; PMCID: PMC11156520.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone. Curr Osteoporos Rep. 2023 Aug; 21(4):414-425. Carroll M, Alliston T, Dole N. PMID: 37395891.
      View in: PubMed   Mentions: 2     Fields:    
    18. Zoledronic acid improves bone quality and muscle function in a high bone turnover state. bioRxiv. 2023 Jun 05. Trivedi T, Manaa M, John S, Reiken S, Murthy S, Pagnotti GM, Dole NS, She Y, Suresh S, Hain BA, Regan J, Ofer R, Wright L, Robling A, Cao X, Alliston T, Marks AR, Waning DL, Mohammad KS, Guise TA. PMID: 37333318; PMCID: PMC10274651.
      View in: PubMed   Mentions:
    19. Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease. J Bone Metab. 2023 02; 30(1):1-29. Schurman CA, Burton JB, Rose J, Ellerby LM, Alliston T, Schilling B. PMID: 36950837; PMCID: PMC10036181.
      View in: PubMed   Mentions: 5  
    20. Bone-cartilage crosstalk informed by aging mouse bone transcriptomics and human osteoarthritis genome-wide association studies. Bone Rep. 2023 Jun; 18:101647. Kaya S, Bailey KN, Schurman CA, Evans DS, Alliston T. PMID: 36636109; PMCID: PMC9830153.
      View in: PubMed   Mentions: 1  
    21. Osteocyte Control of Bone Quality and Fragility in Skeletal Aging. The FASEB Journal. 2022 May 13; 36(S1). Alliston AT. .
      View in: Publisher Site   Mentions:
    22. At the Crux of Joint Crosstalk: TGFβ Signaling in the Synovial Joint. Curr Rheumatol Rep. 2022 06; 24(6):184-197. Bailey KN, Alliston T. PMID: 35499698; PMCID: PMC9184360.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses. J Bone Miner Res. 2022 04; 37(4):804-817. Kaya S, Schurman CA, Dole NS, Evans DS, Alliston T. PMID: 35094432; PMCID: PMC9018503.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress. FASEB J. 2021 10; 35(10):e21883. Dole NS, Yoon J, Monteiro DA, Yang J, Mazur CM, Kaya S, Belair CD, Alliston T. PMID: 34569659; PMCID: PMC9153140.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    25. Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Schurman CA, Verbruggen SW, Alliston T. PMID: 34161267; PMCID: PMC8237574.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    26. Altered canalicular remodeling associated with femur fracture in mice. J Orthop Res. 2022 04; 40(4):891-900. Emami AJ, Sebastian A, Lin YY, Yee CS, Osipov B, Loots GG, Alliston T, Christiansen BA. PMID: 34129247; PMCID: PMC8671555.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Osteocyte-Specific TGFß Signaling Mitigates Obesity-Induced Deregulated Energy Metabolism and Compromised Bone Quality. Journal of the Endocrine Society. 2021 May 3; 5(Suppl 1):a441-a442. Dole DN, Yee YC, Alliston AT. .
      View in: Publisher Site   Mentions:
    28. Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes. FASEB J. 2021 03; 35(3):e21263. Monteiro DA, Dole NS, Campos JL, Kaya S, Schurman CA, Belair CD, Alliston T. PMID: 33570811; PMCID: PMC7888383.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling. Arthritis Rheumatol. 2021 03; 73(3):414-425. Bailey KN, Nguyen J, Yee CS, Dole NS, Dang A, Alliston T. PMID: 33022131; PMCID: PMC9026749.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    30. Assessment of Osteocytes: Techniques for Studying Morphological and Molecular Changes Associated with Perilacunar/Canalicular Remodeling of the Bone Matrix. Methods Mol Biol. 2021; 2230:303-323. Dole NS, Yee CS, Schurman CA, Dallas SL, Alliston T. PMID: 33197021; PMCID: PMC9165628.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    31. A comparison of alendronate to varying magnitude PEMF in mitigating bone loss and altering bone remodeling in skeletally mature osteoporotic rats. Bone. 2021 02; 143:115761. Androjna C, Yee CS, White CR, Waldorff EI, Ryaby JT, Zborowski M, Alliston T, Midura RJ. PMID: 33217628.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    32. Quantitative and qualitative bone imaging: A review of synchrotron radiation microtomography analysis in bone research. J Mech Behav Biomed Mater. 2020 10; 110:103887. Obata Y, Bale HA, Barnard HS, Parkinson DY, Alliston T, Acevedo C. PMID: 32957194.
      View in: PubMed   Mentions: 4     Fields:    
    33. TGFβ Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic. J Bone Miner Res. 2020 08; 35(8):1549-1561. Dole NS, Yee CS, Mazur CM, Acevedo C, Alliston T. PMID: 32282961; PMCID: PMC9126317.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    34. OR29-04 TGFß Regulates Bone Perilacunar/Canalicular Remodeling in a Sexually Dimorphic Manner. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Dole DN, Alliston AT. .
      View in: Publisher Site   Mentions:
    35. The importance of diversity, equity, and inclusion in orthopedic research. J Orthop Res. 2020 08; 38(8):1661-1665. Alliston T, Foucher KC, Frederick B, Hernandez CJ, Iatridis JC, Kozloff KM, Lewis KJ, Liu XS, Mercer DM, Ochia R, Queen RM, Rimnac CM, van der Meulen MCH, Westendorf JJ. PMID: 32267012.
      View in: PubMed   Mentions: 8     Fields:    
    36. Cartilage/Bone Crosstalk in Joint Health and Disease. Osteoarthritis and Cartilage. 2020 Apr 1; 28:s18. Alliston AT. .
      View in: Publisher Site   Mentions:
    37. Biologically Regulated Marrow Stimulation by Blocking TGF-β1 With Losartan Oral Administration Results in Hyaline-like Cartilage Repair: A Rabbit Osteochondral Defect Model. Am J Sports Med. 2020 03; 48(4):974-984. Utsunomiya H, Gao X, Deng Z, Cheng H, Nakama G, Scibetta AC, Ravuri SK, Goldman JL, Lowe WR, Rodkey WG, Alliston T, Philippon MJ, Huard J. PMID: 32027515.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    38. CYLD, a mechanosensitive deubiquitinase, regulates TGFβ signaling in load-induced bone formation. Bone. 2020 02; 131:115148. Nguyen J, Massoumi R, Alliston T. PMID: 31715338; PMCID: PMC7032548.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. Bone Res. 2019; 7:34. Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T. PMID: 31700695; PMCID: PMC6828661.
      View in: PubMed   Mentions: 50     Fields:    
    40. Investigating Osteocytic Perilacunar/Canalicular Remodeling. Curr Osteoporos Rep. 2019 08; 17(4):157-168. Yee CS, Schurman CA, White CR, Alliston T. PMID: 31227998; PMCID: PMC7202397.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    41. Improvement of Cartilage Repair With Biologically Regulated Marrow Stimulation by Blocking TGF-ß1 in A Rabbit Osteochondral Defect Model. Orthopaedic Journal of Sports Medicine. 2019 Jul 1; 7(7 suppl5):2325967119s0026. Utsunomiya UH, Gao GX, Deng DZ, Cheng CH, Scibetta SA, Ravuri RS, Lowe LW, Philippon PM, Alliston AT, Huard HJ. .
      View in: Publisher Site   Mentions:
    42. Bone Quality Sleuths: Uncovering Tissue-Level Mechanisms of Bone Fragility in Human Type 2 Diabetes. J Bone Miner Res. 2019 07; 34(7):1189-1190. Alliston T, Schafer A. PMID: 31225923; PMCID: PMC7002018.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl/6 mice. Bone. 2019 10; 127:91-103. Heveran CM, Schurman CA, Acevedo C, Livingston EW, Howe D, Schaible EG, Hunt HB, Rauff A, Donnelly E, Carpenter RD, Levi M, Lau AG, Bateman TA, Alliston T, King KB, Ferguson VL. PMID: 31055118; PMCID: PMC6760860.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    44. T1ρ-based fibril-reinforced poroviscoelastic constitutive relation of human articular cartilage using inverse finite element technology. Quant Imaging Med Surg. 2019 Mar; 9(3):359-370. Wan C, Ge L, Souza RB, Tang SY, Alliston T, Hao Z, Li X. PMID: 31032184; PMCID: PMC6462578.
      View in: PubMed   Mentions: 5  
    45. Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling. Bone Rep. 2018 Dec; 9:145-153. Alemi AS, Mazur CM, Fowler TW, Woo JJ, Knott PD, Alliston T. PMID: 30306100; PMCID: PMC6176786.
      View in: PubMed   Mentions: 11  
    46. Bone marrow lesions in osteoarthritis: What lies beneath. J Orthop Res. 2018 07; 36(7):1818-1825. Alliston T, Hernandez CJ, Findlay DM, Felson DT, Kennedy OD. PMID: 29266428; PMCID: PMC8607515.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    47. Treatment with anti-Sclerostin antibody to stimulate mandibular bone formation. Head Neck. 2018 07; 40(7):1453-1460. Tamplen M, Fowler T, Markey J, Knott PD, Suva LJ, Alliston T. PMID: 29522281; PMCID: PMC6037571.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    48. Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes. J Bone Miner Res. 2018 06; 33(6):1066-1075. Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ, Fields AJ. PMID: 29342321; PMCID: PMC6011658.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    49. Fatigue as the missing link between bone fragility and fracture. Nat Biomed Eng. 2018 02; 2(2):62-71. Acevedo C, Stadelmann VA, Pioletti DP, Alliston T, Ritchie RO. PMID: 31015620.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    50. A modular approach to creating large engineered cartilage surfaces. J Biomech. 2018 01 23; 67:177-183. Ford AC, Chui WF, Zeng AY, Nandy A, Liebenberg E, Carraro C, Kazakia G, Alliston T, O'Connell GD. PMID: 29273221; PMCID: PMC5767151.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    51. Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling. Cell Rep. 2017 Nov 28; 21(9):2585-2596. Dole NS, Mazur CM, Acevedo C, Lopez JP, Monteiro DA, Fowler TW, Gludovatz B, Walsh F, Regan JN, Messina S, Evans DS, Lang TF, Zhang B, Ritchie RO, Mohammad KS, Alliston T. PMID: 29186693; PMCID: PMC6014615.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    52. Dynamic imaging demonstrates that pulsed electromagnetic fields (PEMF) suppress IL-6 transcription in bovine nucleus pulposus cells. J Orthop Res. 2018 02; 36(2):778-787. Tang X, Alliston T, Coughlin D, Miller S, Zhang N, Waldorff EI, Ryaby JT, Lotz JC. PMID: 28851112; PMCID: PMC5873378.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    53. Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis. Sci Rep. 2017 03 22; 7:44618. Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T. PMID: 28327602; PMCID: PMC5361115.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    54. Smad4 regulates growth plate matrix production and chondrocyte polarity. Biol Open. 2017 Mar 15; 6(3):358-364. Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T. PMID: 28167493; PMCID: PMC5374397.
      View in: PubMed   Mentions: 5     Fields:    
    55. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2017 01; 35(1):61-73. Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC. PMID: 27699833; PMCID: PMC5258652.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    56. Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone. 2016 08; 89:7-15. Jáuregui EJ, Akil O, Acevedo C, Hall-Glenn F, Tsai BS, Bale HA, Liebenberg E, Humphrey MB, Ritchie RO, Lustig LR, Alliston T. PMID: 27085457; PMCID: PMC4916019.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    57. Mechanobiology of TGFβ signaling in the skeleton. Matrix Biol. 2016 May-Jul; 52-54:413-425. Rys JP, Monteiro DA, Alliston T. PMID: 26877077; PMCID: PMC4875828.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    58. Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension. Elife. 2015 Dec 10; 4:e09300. Rys JP, DuFort CC, Monteiro DA, Baird MA, Oses-Prieto JA, Chand S, Burlingame AL, Davidson MW, Alliston TN. PMID: 26652004; PMCID: PMC4728123.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    59. Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage. NMR Biomed. 2015 May; 28(5):523-8. Tufts L, Shet Vishnudas K, Fu E, Kurhanewicz J, Ries M, Alliston T, Li X. PMID: 25761416; PMCID: PMC4400260.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    60. Pulsed Electromagnetic Fields (PEMF) Inhibit Matrix Metalloproteinase-13 Expression in Human Annulus Fibrosus Cells. The Spine Journal. 2014 Nov 1; 14(11):s167. Tang TX, Willardson WR, Coughlin CD, Alliston AT, Lotz LJ. .
      View in: Publisher Site   Mentions:
    61. Calluses flex their muscles to align bone fragments during fracture repair. Dev Cell. 2014 Oct 27; 31(2):137-8. Nguyen J, Alliston T. PMID: 25373771; PMCID: PMC4492116.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    62. Biological regulation of bone quality. Curr Osteoporos Rep. 2014 Sep; 12(3):366-75. Alliston T. PMID: 24894149; PMCID: PMC4134366.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    63. How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res. 2014 Jun; 29(6):1392-1401. Carriero A, Zimmermann EA, Paluszny A, Tang SY, Bale H, Busse B, Alliston T, Kazakia G, Ritchie RO, Shefelbine SJ. PMID: 24420672; PMCID: PMC4477967.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    64. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989. Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC. PMID: 24788917; PMCID: PMC4006800.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    65. Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium. ACS Chem Biol. 2014 Mar 21; 9(3):692-702. Lim M, Otto-Duessel M, He M, Su L, Nguyen D, Chin E, Alliston T, Jones JO. PMID: 24354286; PMCID: PMC3962707.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    66. Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Dev Biol. 2014 Jan 15; 385(2):380-95. Hall J, Jheon AH, Ealba EL, Eames BF, Butcher KD, Mak SS, Ladher R, Alliston T, Schneider RA. PMID: 24262986; PMCID: PMC3953612.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    67. Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration. Laryngoscope. 2013 Dec; 123(12):3156-61. Gould TW, Birchall JP, Mallick AS, Alliston T, Lustig LR, Shakesheff KM, Rahman CV. PMID: 23670365; PMCID: PMC4501022.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    68. Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. J Orthop Res. 2013 Sep; 31(9):1475-83. Berthet E, Chen C, Butcher K, Schneider RA, Alliston T, Amirtharajah M. PMID: 23653374; PMCID: PMC3960924.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    69. Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage. Biophys J. 2013 Apr 16; 104(8):1794-804. Albro MB, Nims RJ, Cigan AD, Yeroushalmi KJ, Alliston T, Hung CT, Ateshian GA. PMID: 23601326; PMCID: PMC3627867.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    70. Regulation of postnatal bone homeostasis by TGFβ. Bonekey Rep. 2013 Jan 09; 2:255. Tang SY, Alliston T. PMID: 24404376; PMCID: PMC3722719.
      View in: PubMed   Mentions: 43  
    71. Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism. PLoS One. 2013; 8(1):e53813. Nguyen J, Tang SY, Nguyen D, Alliston T. PMID: 23308287; PMCID: PMC3538690.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    72. Prolonged alendronate treatment prevents the decline in serum TGF-β1 levels and reduces cortical bone strength in long-term estrogen deficiency rat model. Bone. 2013 Jan; 52(1):424-32. Jia J, Yao W, Amugongo S, Shahnazari M, Dai W, Lay YA, Olvera D, Zimmermann EA, Ritchie RO, Li CS, Alliston T, Lane NE. PMID: 23088940; PMCID: PMC3804116.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    73. Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum. 2012 Oct; 64(10):3278-89. Chen CG, Thuillier D, Chin EN, Alliston T. PMID: 22674505; PMCID: PMC3544176.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    74. Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res. 2012 Sep; 27(9):1936-50. Tang SY, Herber RP, Ho SP, Alliston T. PMID: 22549931; PMCID: PMC3415585.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    75. Smad3 Modulates Tendon Gene Expression and Interacts with Key Tendon Transcription Factors Not a clinical study. The Journal Of Hand Surgery. 2012 Sep 1; 37(8):20-21. Amirtharajah AM, Berthet BE, Chen CC, Alliston AT. .
      View in: Publisher Site   Mentions:
    76. ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation. Mol Biol Cell. 2012 Sep; 23(18):3731-42. Allen JL, Cooke ME, Alliston T. PMID: 22833566; PMCID: PMC3442419.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    77. 150 QUANTITATIVE AND HISTOPATHOLOGICAL ANALYSIS OF OSTEO-ARTHRITIC CARTILAGE USING MRI, HRMAS SPECTROSCOPY AND IMMUNO-HISTOCHEMISTRY. Osteoarthritis and Cartilage. 2011 Sep 1; 19:s76. Shet SK, Liang LF, Alliston AT, Yoshihara YH, Kurhanewicz KJ, Ries RM, Horvai HA, Li LX. .
      View in: Publisher Site   Mentions:
    78. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone. Biomaterials. 2011 Dec; 32(34):8892-904. Barth HD, Zimmermann EA, Schaible E, Tang SY, Alliston T, Ritchie RO. PMID: 21885114; PMCID: PMC4405888.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    79. Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14416-21. Zimmermann EA, Schaible E, Bale H, Barth HD, Tang SY, Reichert P, Busse B, Alliston T, Ager JW, Ritchie RO. PMID: 21873221; PMCID: PMC3167515.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    80. TGFß and Runx2 calibration of bone extracellular matrix quality for tissue-specific function. BoneKEy Reports. 2011 Aug 1; 8(8):370-380. Alliston AT, Chang CJ. .
      View in: Publisher Site   Mentions:
    81. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8. Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. PMID: 21816228; PMCID: PMC3188316.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    82. Local tissue properties of human osteoarthritic cartilage correlate with magnetic resonance T(1) rho relaxation times. J Orthop Res. 2011 Sep; 29(9):1312-9. Tang SY, Souza RB, Ries M, Hansma PK, Alliston T, Li X. PMID: 21445940; PMCID: PMC4092115.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    83. The use of polyacrylamide gels for mechanical calibration of cartilage--a combined nanoindentation and unconfined compression study. J Mech Behav Biomed Mater. 2011 Oct; 4(7):1540-7. Li C, Allen J, Alliston T, Pruitt LA. PMID: 21783163; PMCID: PMC4507509.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    84. Examination of Bone Ossification Markers in Cochlear Development. The Laryngoscope. 2011 Jan 1; 121(S5):s313-s313. Chang CJ, Butcher BK, Akil AO, Schneider SR, Lustig LL, Alliston AT. .
      View in: Publisher Site   Mentions:
    85. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. PMID: 20941479; PMCID: PMC3132390.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    86. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. PMID: 20847738; PMCID: PMC2948188.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    87. In situ Materials Characterization using the Tissue Diagnostic Instrument. Polym Test. 2010 Apr 01; 29(2):159-163. Tang SY, Mathews P, Randall C, Yurtsev E, Fields K, Wong A, Kuo A, Alliston T, Hansma P. PMID: 20582333; PMCID: PMC2891070.
      View in: PubMed   Mentions: 3  
    88. Osteopontin deficiency increases bone fragility but preserves bone mass. Bone. 2010 Jun; 46(6):1564-73. Thurner PJ, Chen CG, Ionova-Martin S, Sun L, Harman A, Porter A, Ager JW, Ritchie RO, Alliston T. PMID: 20171304; PMCID: PMC2875278.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    89. Chondroitin sulfate and growth factor signaling in the skeleton: Possible links to MPS VI. J Pediatr Rehabil Med. 2010; 3(2):129-38. Alliston T. PMID: 20628554; PMCID: PMC2901997.
      View in: PubMed   Mentions: 12     Fields:    
    90. Tissue Interactions in Long Bone Development. Bone and Development. 2010 Jan 1; 25-37. Colnot CC, Alliston AT. .
      View in: Publisher Site   Mentions:
    91. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 2010 Jan; 46(1):217-25. Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. PMID: 19853069; PMCID: PMC4501030.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    92. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. PMID: 19485522; PMCID: PMC2832056.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    93. TGF-beta and bone matrix material properties. Bone. 2009 May 1; 44:s34. Alliston AT. .
      View in: Publisher Site   Mentions:
    94. A tense situation: forcing tumour progression. Nat Rev Cancer. 2009 Feb; 9(2):108-22. Butcher DT, Alliston T, Weaver VM. PMID: 19165226; PMCID: PMC2649117.
      View in: PubMed   Mentions: 888     Fields:    Translation:HumansAnimalsCells
    95. Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One. 2009; 4(4):e5275. Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T. PMID: 19357790; PMCID: PMC2666804.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    96. Chapter 53 Transforming Growth Factor-ß. Principles of Bone Biology. 2008 Jan 1; 1145-1166. Dallas DS, Alliston AT, Bonewald BL. .
      View in: Publisher Site   Mentions:
    97. Elevated TGF-beta2 signaling in dentin results in sex related enamel defects. Arch Oral Biol. 2007 Sep; 52(9):814-21. Saeki K, Hilton JF, Alliston T, Habelitz S, Marshall SJ, Marshall GW, Denbesten P. PMID: 17391645; PMCID: PMC2043093.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    98. TGF-beta regulation of osteoblast differentiation and bone matrix properties. J Musculoskelet Neuronal Interact. 2006 Oct-Dec; 6(4):349-50. Alliston T. PMID: 17185818.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    99. Smads In Mesenchymal Differentiation. Smad Signal Transduction. 2006 Jan 1; 5:93-112. Derynck DR, Choy CL, Alliston AT. .
      View in: Publisher Site   Mentions:
    100. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18813-8. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. PMID: 16354837; PMCID: PMC1323171.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    101. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20; 24(14):2543-55. Kang JS, Alliston T, Delston R, Derynck R. PMID: 15990875; PMCID: PMC1176457.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    102. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005 Jun 24; 280(25):24227-37. Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R. PMID: 15849193.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    103. Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. J Biol Chem. 2004 Apr 30; 279(18):19327-34. Selvamurugan N, Kwok S, Alliston T, Reiss M, Partridge NC. PMID: 14982932.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    104. Medicine: interfering with bone remodelling. Nature. 2002 Apr 18; 416(6882):686-7. Alliston T, Derynck R. PMID: 11961535.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    105. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 2001 May 01; 20(9):2254-72. Alliston T, Choy L, Ducy P, Karsenty G, Derynck R. PMID: 11331591; PMCID: PMC125448.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansAnimalsCells
    106. Expression and localization of serum/glucocorticoid-induced kinase in the rat ovary: relation to follicular growth and differentiation. Endocrinology. 2000 Jan; 141(1):385-95. Alliston TN, Gonzalez-Robayna IJ, Buse P, Firestone GL, Richards JS. PMID: 10614661.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    107. Expression and Localization of Serum/Glucocorticoid-Induced Kinase in the Rat Ovary: Relation to Follicular Growth and Differentiation1. Endocrinology. 2000 Jan 1; 141(1):385-395. Alliston AT, Gonzalez-Robayna GI, Buse BP, Firestone FG, Richards RJ. .
      View in: Publisher Site   Mentions:
    108. Functional and subcellular changes in the A-kinase-signaling pathway: relation to aromatase and Sgk expression during the transition of granulosa cells to luteal cells. Mol Endocrinol. 1999 Aug; 13(8):1318-37. Gonzalez-Robayna IJ, Alliston TN, Buse P, Firestone GL, Richards JS. PMID: 10446906.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    109. Molecular mechanisms of ovulation and luteinization. Mol Cell Endocrinol. 1998 Oct 25; 145(1-2):47-54. Richards JS, Russell DL, Robker RL, Dajee M, Alliston TN. PMID: 9922098.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    110. Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: a functional role for the Sp1 family in promoter activity. Mol Endocrinol. 1997 Dec; 11(13):1934-49. Alliston TN, Maiyar AC, Buse P, Firestone GL, Richards JS. PMID: 9415398.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    111. Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes. Recent Prog Horm Res. 1995; 50:223-54. Richards JS, Fitzpatrick SL, Clemens JW, Morris JK, Alliston T, Sirois J. PMID: 7740159.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
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