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Characterization of mice carrying a neurodevelopmental disease-associated GluN2B(L825V) variant. J Neurosci. 2024 Jun 26.
Candelas Serra M, Kuchtiak V, Kubik-Zahorodna A, Kysilov B, Fili K, Hrcka Krausova B, Abramova V, Dobrovolski M, Harant K, Bozikova P, Cerny J, Prochazka J, Kasparek P, Sedlacek R, Balik A, Smejkalova T, Vyklicky L. PMID: 38926089.
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PubMed Mentions: Fields:
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Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence. Hum Mol Genet. 2024 Feb 28; 33(6):491-500.
Sunny SS, Lachova J, Kasparek P, Palkova M, Spoutil F, Prochazka J, Sedlacek R, Liskova P, Kozmik Z. PMID: 37971355.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2):250-262.
Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 38321203.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. bioRxiv. 2023 Sep 22.
Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 37790430; PMCID: PMC10542170.
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Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Nat Commun. 2023 Jun 15; 14(1):3565.
Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I. PMID: 37322005; PMCID: PMC10272192.
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PubMed Mentions: Fields:
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A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Nat Commun. 2023 05 29; 14(1):3092.
Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I. PMID: 37248239; PMCID: PMC10226981.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity. Cell Mol Life Sci. 2023 Apr 29; 80(5):135.
Kahveci-Türköz S, Bläsius K, Wozniak J, Rinkens C, Seifert A, Kasparek P, Ohm H, Oltzen S, Nieszporek M, Schwarz N, Babendreyer A, Preisinger C, Sedlacek R, Ludwig A, Düsterhöft S. PMID: 37119365; PMCID: PMC10148629.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions. Sci Rep. 2023 01 26; 13(1):1471.
Spoutil F, Aranaz-Novaliches G, Prochazkova M, Wald T, Novosadova V, Kasparek P, Osicka R, Reseland JE, Lyngstadaas SP, Tiainen H, Bousova K, Vondrasek J, Sedlacek R, Prochazka J. PMID: 36702824; PMCID: PMC9879986.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Ablation of Gabra5 Influences Corticosterone Levels and Anxiety-like Behavior in Mice. Genes (Basel). 2023 01 21; 14(2).
Syding LA, Kubik-Zahorodna A, Reguera DP, Nickl P, Hruskova B, Kralikova M, Kopkanova J, Novosadova V, Kasparek P, Prochazka J, Rozman J, Turecek R, Sedlacek R. PMID: 36833213; PMCID: PMC9956889.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Front Immunol. 2022; 13:1035226.
Pavliuchenko N, Duric I, Kralova J, Fabisik M, Spoutil F, Prochazka J, Kasparek P, Pokorna J, Skopcova T, Sedlacek R, Brdicka T. PMID: 36605205; PMCID: PMC9807597.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene. Sci Rep. 2022 10 12; 12(1):17081.
Novakova Z, Milosevic M, Kutil Z, Ondrakova M, Havlinova B, Kasparek P, Sandoval-Acuña C, Korandova Z, Truksa J, Vrbacky M, Rohlena J, Barinka C. PMID: 36224252; PMCID: PMC9556554.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Ube3a Gene. Cells. 2022 09 09; 11(18).
Syding LA, Kubik-Zahorodna A, Nickl P, Novosadova V, Kopkanova J, Kasparek P, Prochazka J, Sedlacek R. PMID: 36139390; PMCID: PMC9496699.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Front Cell Dev Biol. 2022; 10:914053.
Dibus N, Zobalova E, Monleon MAM, Korinek V, Filipp D, Petrusova J, Sedlacek R, Kasparek P, Cermak L. PMID: 35769260; PMCID: PMC9234700.
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PubMed Mentions:
3
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Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551. Noncoding RNA. 2022 May 06; 8(3).
Engelhard CA, Huang C, Khani S, Kasparek P, Prochazka J, Rozman J, Reguera DP, Sedlacek R, Kornfeld JW. PMID: 35645339; PMCID: PMC9149892.
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PubMed Mentions:
2
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Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies. Biol Psychiatry. 2022 07 01; 92(1):81-95.
Karmon G, Sragovich S, Hacohen-Kleiman G, Ben-Horin-Hazak I, Kasparek P, Schuster B, Sedlacek R, Pasmanik-Chor M, Theotokis P, Touloumi O, Zoidou S, Huang L, Wu PY, Shi R, Kapitansky O, Lobyntseva A, Giladi E, Shapira G, Shomron N, Bereswill S, Heimesaat MM, Grigoriadis N, McKinney RA, Rubinstein M, Gozes I. PMID: 34865853.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Importing genetically altered animals: ensuring quality. Mamm Genome. 2022 03; 33(1):100-107.
Birling MC, Fray MD, Kasparek P, Kopkanova J, Massimi M, Matteoni R, Montoliu L, Nutter LMJ, Raspa M, Rozman J, Ryder EJ, Scavizzi F, Voikar V, Wells S, Pavlovic G, Teboul L. PMID: 34536110; PMCID: PMC8913481.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis. Sci Rep. 2021 06 01; 11(1):11414.
Zbodakova O, Chalupsky K, Sarnova L, Kasparek P, Jirouskova M, Gregor M, Sedlacek R. PMID: 34075077; PMCID: PMC8169909.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. Int J Mol Sci. 2021 May 20; 22(10).
Lidak T, Baloghova N, Korinek V, Sedlacek R, Balounova J, Kasparek P, Cermak L. PMID: 34065512; PMCID: PMC8161014.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release. Cell Mol Life Sci. 2021 Jun; 78(11):5015-5040.
Düsterhöft S, Kahveci-Türköz S, Wozniak J, Seifert A, Kasparek P, Ohm H, Liu S, Kopkanova J, Lokau J, Garbers C, Preisinger C, Sedlacek R, Freeman M, Ludwig A. PMID: 33950315; PMCID: PMC8233286.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation". Genome Biol. 2021 04 07; 22(1):99.
Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb K, Eudy JD, Gan L, Gao J, Gonzales A, Guntur A, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majeweska L, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford A, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. PMID: 33827648; PMCID: PMC8025318.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A resource of targeted mutant mouse lines for 5,061 genes. Nat Genet. 2021 04; 53(4):416-419.
Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y, International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA. PMID: 33833456; PMCID: PMC8397259.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance. EMBO Rep. 2021 02 03; 22(2):e50785.
Tsyklauri O, Niederlova V, Forsythe E, Prasai A, Drobek A, Kasparek P, Sparks K, Trachtulec Z, Prochazka J, Sedlacek R, Beales P, Huranova M, Stepanek O. PMID: 33426789; PMCID: PMC7857422.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1. Cell Rep. 2020 12 22; 33(12):108548.
Desideri F, Cipriano A, Petrezselyova S, Buonaiuto G, Santini T, Kasparek P, Prochazka J, Janson G, Paiardini A, Calicchio A, Colantoni A, Sedlacek R, Bozzoni I, Ballarino M. PMID: 33357424; PMCID: PMC7773549.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner. Int J Mol Sci. 2020 Aug 19; 21(17).
Seifert A, Wozniak J, Düsterhöft S, Kasparek P, Sedlacek R, Dreschers S, Orlikowsky TW, Yildiz D, Ludwig A. PMID: 32825187; PMCID: PMC7503280.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Efficient allele conversion in mouse zygotes and primary cells based on electroporation of Cre protein. Methods. 2021 07; 191:87-94.
Jenickova I, Kasparek P, Petrezselyova S, Elias J, Prochazka J, Kopkanova J, Navratil M, Barinka C, Sedlacek R. PMID: 32717290.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review. Cells. 2020 04 16; 9(4).
Syding LA, Nickl P, Kasparek P, Sedlacek R. PMID: 32316223; PMCID: PMC7226972.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. EMBO Rep. 2020 03 04; 21(3):e48512.
Ziak J, Weissova R, Jerábková K, Janikova M, Maimon R, Petrasek T, Pukajova B, Kleisnerova M, Wang M, Brill MS, Kasparek P, Zhou X, Alvarez-Bolado G, Sedlacek R, Misgeld T, Stuchlik A, Perlson E, Balastik M. PMID: 31919978; PMCID: PMC7054682.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis. 2019 10 28; 10(11):818.
Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janecková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L. PMID: 31659152; PMCID: PMC6817818.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 08 26; 20(1):171.
Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. PMID: 31446895; PMCID: PMC6709553.
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PubMed Mentions:
40 Fields:
Translation:
Animals
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Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models. Biol Chem. 2018 09 25; 399(9):1085-1089.
Horn M, Zbodakova O, Kasparek P, Srp J, Haneckova R, Hradilek M, Mares M, Sedlacek R. PMID: 29885275.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases. Biol Chem. 2018 09 25; 399(9):1053-1064.
Magnen M, Elsässer BM, Zbodakova O, Kasparek P, Gueugnon F, Petit-Courty A, Sedlacek R, Goettig P, Courty Y. PMID: 29883316.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Cell Mol Life Sci. 2018 09; 75(17):3251-3267.
Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P. PMID: 29520422.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1641-E1650.
Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R. PMID: 28196895; PMCID: PMC5338493.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet. 2017 01; 13(1):e1006566.
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R. PMID: 28095415; PMCID: PMC5283769.
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PubMed Mentions:
26 Fields:
Translation:
Animals
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A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene. Biol Chem. 2016 12 01; 397(12):1287-1292.
Kasparek P, Ileninova Z, Haneckova R, Kanchev I, Jenickova I, Sedlacek R. PMID: 27543783.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. Biochim Biophys Acta Mol Cell Res. 2017 Jan; 1864(1):217-230.
Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P. PMID: 27818272.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol. 2016 07; 9(4):974-85.
Brauer R, Tureckova J, Kanchev I, Khoylou M, Skarda J, Prochazka J, Spoutil F, Beck IM, Zbodakova O, Kasparek P, Korinek V, Chalupsky K, Karhu T, Herzig KH, Hajduch M, Gregor M, Sedlacek R. PMID: 26555704.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes. Physiol Res. 2015; 64(2):247-54.
Prukova D, Ileninova Z, Antosova B, Kasparek P, Gregor M, Sedlacek R. PMID: 25317684.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS Lett. 2014 Nov 03; 588(21):3982-8.
Kasparek P, Krausova M, Haneckova R, Kriz V, Zbodakova O, Korinek V, Sedlacek R. PMID: 25241166.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing. Transgenic Res. 2012 Jun; 21(3):683-9.
Kasparek P, Krenek P, Buryova H, Suchanova S, Beck IM, Sedlacek R. PMID: 22020981.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells