Zev Gartner, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
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    Collapse Biography 
    Collapse Education and Training
    UC BerkeleyB.S.1999Chemistry
    Harvard UniversityPh.D.2004Chemistry
    UC BerkeleyPost Doctoral2008Chemistry
    Collapse Awards and Honors
    1998  - 1998Beckman Scholar
    UC Berkeley1999  - 1999High Honors in Chemistry
    National Science Foundation Graduate Research2000  - 2000Fellowship
    Bristol-Myers Squibb2003  - 2003Fellowship
    Harvard2003  - 2003Merit Fellowship
    2005  - 2005IUPAC Prize for Young Chemists "for the best Ph.D. theses in the chemical sciences."
    2006  - 2006Jane Coffin Childs Postdoctoral Fellow
    2008  - 2008Sandler Opportunity Award
    2010  - 2010Kimmel Scholar Award
    2010  - 2010Era of Hope Scholar Award
    NIH2013New Innovator Award
    Popular Science2015Brilliant 10

    Collapse Overview 
    Collapse Overview
    The human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells must work together for our bodies to function correctly. However, it remains a mystery how such an enormous diversity of cells coordinate their behaviors.

    Tissue structure - or the composition and physical arrangement of cells, extracellular matrix, and diffusible molecules - helps to coordinate cellular behaviors by organizing the flow of chemical, mechanical, and electrical information between cells. Thus, building tissue structure correctly and maintaining tissue structure over time are prerequisites for engineering functional organs and stopping the progression of diseases like cancer.

    We are interested in three general questions about how tissue structure forms and functions:

    (i) How does tissue structure form through the process of self-organization?
    (ii) How does tissue structure help cells to arrive at collective decisions and to organize collective behaviors?
    (iii) How does tissue structure breakdown during the progression of diseases like cancer?

    To answer these questions we take a synthetic approach, building human tissues from the bottom-up. This approach allows us to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behaviors. We focus primarily on the cells and tissues of the human breast, and our work incorporates experimental principles from the chemical, biological, and engineering sciences.

    Collapse Research 
    Collapse Research Activities and Funding
    Identifying the intercellular networks regulating estrogen receptor expression with a high definition single cell printer
    NIH/NCI R21CA195709Sep 18, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Small, modular, and monovalent Quantum Dots for single molecule imaging of Notch
    NIH/NIBIB R21EB018044Mar 1, 2014 - Feb 29, 2016
    Role: Co-Principal Investigator
    Total synthesis of the human mammary gland
    NIH/NICHD DP2HD080351Sep 30, 2013 - Jul 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Global Health
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 Jun 17. PMID: 31209384.
      View in: PubMed
    2. Lehmann R, Lee CM, Shugart EC, Benedetti M, Charo RA, Gartner Z, Hogan B, Knoblich J, Nelson CM, Wilson KM. Human organoids: a new dimension in cell biology. Mol Biol Cell. 2019 05 01; 30(10):1129-1137. PMID: 31034354.
      View in: PubMed
    3. McGinnis CS, Murrow LM, Gartner ZJ. DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors. Cell Syst. 2019 Apr 24; 8(4):329-337.e4. PMID: 30954475.
      View in: PubMed
    4. Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 Nov 06; 115(45):11585-11590. PMID: 30348790.
      View in: PubMed
    5. Gruber TD, Krishnamurthy C, Grimm JB, Tadross MR, Wysocki LM, Gartner ZJ, Lavis LD. Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. ACS Chem Biol. 2018 Oct 19; 13(10):2888-2896. PMID: 30111097.
      View in: PubMed
    6. Hughes AJ, Mornin JD, Biswas SK, Beck LE, Bauer DP, Raj A, Bianco S, Gartner ZJ. Quanti.us: a tool for rapid, flexible, crowd-based annotation of images. Nat Methods. 2018 Aug; 15(8):587-590. PMID: 30065368.
      View in: PubMed
    7. Siltanen CA, Cole RH, Poust S, Chao L, Tyerman J, Kaufmann-Malaga B, Ubersax J, Gartner ZJ, Abate AR. An Oil-Free Picodrop Bioassay Platform for Synthetic Biology. Sci Rep. 2018 May 21; 8(1):7913. PMID: 29784937.
      View in: PubMed
    8. Kim J, Han S, Lei A, Miyano M, Bloom J, Srivastava V, Stampfer MM, Gartner ZJ, LaBarge MA, Sohn LL. Characterizing cellular mechanical phenotypes with mechano-node-pore sensing. Microsyst Nanoeng. 2018; 4. PMID: 29780657.
      View in: PubMed
    9. Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ. Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Rep. 2018 03 06; 22(10):2593-2600. PMID: 29514089.
      View in: PubMed
    10. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 01 22; 44(2):165-178.e6. PMID: 29290586.
      View in: PubMed
    11. Hu JL, Todhunter ME, LaBarge MA, Gartner ZJ. Opportunities for organoids as new models of aging. J Cell Biol. 2018 01 02; 217(1):39-50. PMID: 29263081.
      View in: PubMed
    12. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889. PMID: 28817122.
      View in: PubMed
    13. Cole RH, Tang SY, Siltanen CA, Shahi P, Zhang JQ, Poust S, Gartner ZJ, Abate AR. Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8728-8733. PMID: 28760972.
      View in: PubMed
    14. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2017 06 15; 169(7):1357. PMID: 28622515.
      View in: PubMed
    15. Gartner ZJ, Prescher JA, Lavis LD. Unraveling cell-to-cell signaling networks with chemical biology. Nat Chem Biol. 2017 05 17; 13(6):564-568. PMID: 28514428.
      View in: PubMed
    16. Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 03 23; 169(1):108-119.e20. PMID: 28340336.
      View in: PubMed
    17. Murrow LM, Weber RJ, Gartner ZJ. Dissecting the stem cell niche with organoid models: an engineering-based approach. Development. 2017 03 15; 144(6):998-1007. PMID: 28292846.
      View in: PubMed
    18. Weber RJ, Desai TA, Gartner ZJ. Non-autonomous cell proliferation in the mammary gland and cancer. Curr Opin Cell Biol. 2017 04; 45:55-61. PMID: 28314237.
      View in: PubMed
    19. Shahi P, Kim SC, Haliburton JR, Gartner ZJ, Abate AR. Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding. Sci Rep. 2017 03 14; 7:44447. PMID: 28290550.
      View in: PubMed
    20. Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2017 01; 35(1):61-73. PMID: 27699833.
      View in: PubMed
    21. Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner ZJ, Desai TA. Probing the luminal microenvironment of reconstituted epithelial microtissues. Sci Rep. 2016 09 13; 6:33148. PMID: 27619235.
      View in: PubMed
    22. Todhunter ME, Weber RJ, Farlow J, Jee NY, Cerchiari AE, Gartner ZJ. Fabrication of 3-D Reconstituted Organoid Arrays by DNA-Programmed Assembly of Cells (DPAC). Curr Protoc Chem Biol. 2016 09 13; 8(3):147-78. PMID: 27622567.
      View in: PubMed
    23. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 02; 165(6):1507-1518. PMID: 27180907; PMCID: PMC4892966 [Available on 06/02/17].
    24. Cole RH, Gartner ZJ, Abate AR. Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers. J Vis Exp. 2016 05 05; (111). PMID: 27214249.
      View in: PubMed
    25. Coyle M, Hu J, Gartner Z. Mysteries in a Minimal Genome. ACS Cent Sci. 2016 May 25; 2(5):274-7. PMID: 27280161; PMCID: PMC4882734.
    26. Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner ZJ, Schaffer DV. Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities. Nat Commun. 2016 Jan 12; 7:10309. PMID: 26754526.
      View in: PubMed
    27. Broaders KE, Cerchiari AE, Gartner ZJ. Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances. Integr Biol (Camb). 2015 Dec; 7(12):1611-21. PMID: 26507156; PMCID: PMC4666816 [Available on 12/30/16].
    28. Todhunter ME, Jee NY, Hughes AJ, Coyle MC, Cerchiari A, Farlow J, Garbe JC, LaBarge MA, Desai TA, Gartner ZJ. Programmed synthesis of three-dimensional tissues. Nat Methods. 2015 Oct; 12(10):975-81. PMID: 26322836.
      View in: PubMed
    29. Cole RH, de Lange N, Gartner ZJ, Abate AR. Compact and modular multicolour fluorescence detector for droplet microfluidics. Lab Chip. 2015 Jul 07; 15(13):2754-8. PMID: 26032595; PMCID: PMC4505729.
    30. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92. PMID: 25633040.
      View in: PubMed
    31. Cerchiari A, Garbe JC, Todhunter ME, Jee NY, Pinney JR, LaBarge MA, Desai TA, Gartner ZJ. Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding. Tissue Eng Part C Methods. 2015 Jun; 21(6):541-7. PMID: 25351430; PMCID: PMC4442595.
    32. Weber RJ, Liang SI, Selden NS, Desai TA, Gartner ZJ. Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly. Biomacromolecules. 2014 Dec 08; 15(12):4621-6. PMID: 25325667; PMCID: PMC4261982.
    33. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. Production and targeting of monovalent quantum dots. J Vis Exp. 2014 Oct 23; (92):e52198. PMID: 25407345; PMCID: PMC4309134.
    34. Liang SI, McFarland JM, Rabuka D, Gartner ZJ. A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds. J Am Chem Soc. 2014 Aug 06; 136(31):10850-3. PMID: 25029632; PMCID: PMC4132959.
    35. Rosenblatt J, Gartner Z. Cells: Shaping tissues and organs. Mol Biol Cell. 2014 Mar; 25(6):730. PMID: 24626844; PMCID: PMC3952838.
    36. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5. PMID: 24122039; PMCID: PMC3968776.
    37. Sogi KM, Gartner ZJ, Breidenbach MA, Appel MJ, Schelle MW, Bertozzi CR. Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. PLoS One. 2013; 8(6):e65080. PMID: 23762287; PMCID: PMC3675115.
    38. Liu JS, Gartner ZJ. Directing the assembly of spatially organized multicomponent tissues from the bottom up. Trends Cell Biol. 2012 Dec; 22(12):683-91. PMID: 23067679; PMCID: PMC3505240.
    39. Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner ZJ. Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis. Cell Rep. 2012 Nov 29; 2(5):1461-70. PMID: 23041312; PMCID: PMC3634587.
    40. Onoe H, Hsiao SC, Douglas ES, Gartner ZJ, Bertozzi CR, Francis MB, Mathies RA. Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences. Langmuir. 2012 May 29; 28(21):8120-6. PMID: 22512362.
      View in: PubMed
    41. Selden NS, Todhunter ME, Jee NY, Liu JS, Broaders KE, Gartner ZJ. Chemically programmed cell adhesion with membrane-anchored oligonucleotides. J Am Chem Soc. 2012 Jan 18; 134(2):765-8. PMID: 22176556; PMCID: PMC3280587.
    42. Hsiao SC, Shum BJ, Onoe H, Douglas ES, Gartner ZJ, Mathies RA, Bertozzi CR, Francis MB. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir. 2009 Jun 16; 25(12):6985-91. PMID: 19505164.
      View in: PubMed
    43. Gartner ZJ, Bertozzi CR. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4606-10. PMID: 19273855; PMCID: PMC2660766.
    44. Chen X, Wu P, Rousseas M, Okawa D, Gartner Z, Zettl A, Bertozzi CR. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc. 2009 Jan 28; 131(3):890-1. PMID: 19119844; PMCID: PMC2657038.
    45. Gartner ZJ, Tse BN, Grubina R, Doyon JB, Snyder TM, Liu DR. DNA-templated organic synthesis and selection of a library of macrocycles. Science. 2004 Sep 10; 305(5690):1601-5. PMID: 15319493; PMCID: PMC2814051.
    46. Buskirk AR, Ong YC, Gartner ZJ, Liu DR. Directed evolution of ligand dependence: small-molecule-activated protein splicing. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10505-10. PMID: 15247421; PMCID: PMC489967.
    47. Li X, Gartner ZJ, Tse BN, Liu DR. Translation of DNA into synthetic N-acyloxazolidines. J Am Chem Soc. 2004 Apr 28; 126(16):5090-2. PMID: 15099091.
      View in: PubMed
    48. Gartner ZJ, Grubina R, Calderone CT, Liu DR. Two enabling architectures for DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1370-5. PMID: 12671971.
      View in: PubMed
    49. Calderone CT, Puckett JW, Gartner ZJ, Liu DR. Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2002 Nov 04; 41(21):4104-8. PMID: 12412096.
      View in: PubMed
    50. Gartner ZJ, Kanan MW, Liu DR. Multistep small-molecule synthesis programmed by DNA templates. J Am Chem Soc. 2002 Sep 04; 124(35):10304-6. PMID: 12197733.
      View in: PubMed
    51. Gartner ZJ, Kanan MW, Liu DR. Expanding the reaction scope of DNA-templated synthesis. Angew Chem Int Ed Engl. 2002 May 17; 41(10):1796-800. PMID: 19750721.
      View in: PubMed
    52. Gartner ZJ, Liu DR. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules. J Am Chem Soc. 2001 Jul 18; 123(28):6961-3. PMID: 11448217; PMCID: PMC2820563.