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Zev Gartner, PhD

TitleAssociate Professor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address600 16th St
San Francisco CA 94158
Phone415-514-9962
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    Collapse Biography 
    Collapse Education and Training
    UC BerkeleyB.S.1999Chemistry
    Harvard UniversityPh.D.2004Chemistry
    UC BerkeleyPost Doctoral2008Chemistry
    Collapse Awards and Honors
    1998  - 1998Beckman Scholar
    UC Berkeley1999  - 1999High Honors in Chemistry
    National Science Foundation Graduate Research2000  - 2000Fellowship
    Bristol-Myers Squibb2003  - 2003Fellowship
    Harvard2003  - 2003Merit Fellowship
    2005  - 2005IUPAC Prize for Young Chemists "for the best Ph.D. theses in the chemical sciences."
    2006  - 2006Jane Coffin Childs Postdoctoral Fellow
    2008  - 2008Sandler Opportunity Award
    2010  - 2010Kimmel Scholar Award
    2010  - 2010Era of Hope Scholar Award
    NIH2013New Innovator Award
    Popular Science2015Brilliant 10

    Collapse Overview 
    Collapse Overview
    The human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells must work together for our bodies to function correctly. However, it remains a mystery how such an enormous diversity of cells coordinate their behaviors.

    Tissue structure - or the composition and physical arrangement of cells, extracellular matrix, and diffusible molecules - helps to coordinate cellular behaviors by organizing the flow of chemical, mechanical, and electrical information between cells. Thus, building tissue structure correctly and maintaining tissue structure over time are prerequisites for engineering functional organs and stopping the progression of diseases like cancer.

    We are interested in three general questions about how tissue structure forms and functions:

    (i) How does tissue structure form through the process of self-organization?
    (ii) How does tissue structure help cells to arrive at collective decisions and to organize collective behaviors?
    (iii) How does tissue structure breakdown during the progression of diseases like cancer?

    To answer these questions we take a synthetic approach, building human tissues from the bottom-up. This approach allows us to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behaviors. We focus primarily on the cells and tissues of the human breast, and our work incorporates experimental principles from the chemical, biological, and engineering sciences.


    Collapse Research 
    Collapse Research Activities and Funding
    Identifying the intercellular networks regulating estrogen receptor expression with a high definition single cell printer
    NIH/NCI R21CA195709Sep 18, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Small, modular, and monovalent Quantum Dots for single molecule imaging of Notch
    NIH/NIBIB R21EB018044Mar 1, 2014 - Feb 29, 2016
    Role: Co-Principal Investigator
    Total synthesis of the human mammary gland
    NIH/NICHD DP2HD080351Sep 30, 2013 - Jul 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner Z, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889. PMID: 28817122.
      View in: PubMed
    2. Cole RH, Tang SY, Siltanen CA, Shahi P, Zhang JQ, Poust S, Gartner Z, Abate AR. Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells. Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):8728-8733. PMID: 28760972.
      View in: PubMed
    3. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner Z, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2017 Jun 15; 169(7):1357. PMID: 28622515.
      View in: PubMed
    4. Gartner Z, Prescher JA, Lavis LD. Unraveling cell-to-cell signaling networks with chemical biology. Nat Chem Biol. 2017 May 17; 13(6):564-568. PMID: 28514428.
      View in: PubMed
    5. Taylor MJ, Husain K, Gartner Z, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23; 169(1):108-119.e20. PMID: 28340336.
      View in: PubMed
    6. Weber RJ, Desai TA, Gartner Z. Non-autonomous cell proliferation in the mammary gland and cancer. Curr Opin Cell Biol. 2017 Apr; 45:55-61. PMID: 28314237.
      View in: PubMed
    7. Murrow LM, Weber RJ, Gartner Z. Dissecting the stem cell niche with organoid models: an engineering-based approach. Development. 2017 Mar 15; 144(6):998-1007. PMID: 28292846.
      View in: PubMed
    8. Shahi P, Kim SC, Haliburton JR, Gartner Z, Abate AR. Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding. Sci Rep. 2017 Mar 14; 7:44447. PMID: 28290550.
      View in: PubMed
    9. Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner Z, Lotz JC. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2016 Oct 4. PMID: 27699833.
      View in: PubMed
    10. Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner Z, Desai TA. Probing the luminal microenvironment of reconstituted epithelial microtissues. Sci Rep. 2016; 6:33148. PMID: 27619235.
      View in: PubMed
    11. Todhunter ME, Weber RJ, Farlow J, Jee NY, Cerchiari AE, Gartner Z. Fabrication of 3-D Reconstituted Organoid Arrays by DNA-Programmed Assembly of Cells (DPAC). Curr Protoc Chem Biol. 2016; 8(3):147-78. PMID: 27622567.
      View in: PubMed
    12. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner Z, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 2; 165(6):1507-18. PMID: 27180907.
      View in: PubMed
    13. Cole RH, Gartner Z, Abate AR. Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers. J Vis Exp. 2016; (111). PMID: 27214249.
      View in: PubMed
    14. Coyle M, Hu J, Gartner Z. Mysteries in a Minimal Genome. ACS Cent Sci. 2016 May 25; 2(5):274-7. PMID: 27280161.
      View in: PubMed
    15. Chen S, Bremer AW, Scheideler OJ, Na YS, Todhunter ME, Hsiao S, Bomdica PR, Maharbiz MM, Gartner Z, Schaffer DV. Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities. Nat Commun. 2016; 7:10309. PMID: 26754526.
      View in: PubMed
    16. Broaders KE, Cerchiari AE, Gartner Z. Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances. Integr Biol (Camb). 2015 Dec 30; 7(12):1611-21. PMID: 26507156; PMCID: PMC4666816 [Available on 12/30/16].
    17. Todhunter ME, Jee NY, Hughes AJ, Coyle MC, Cerchiari A, Farlow J, Garbe JC, LaBarge MA, Desai TA, Gartner Z. Programmed synthesis of three-dimensional tissues. Nat Methods. 2015 Oct; 12(10):975-81. PMID: 26322836; PMCID: PMC4589502 [Available on 04/01/16].
    18. Cole RH, de Lange N, Gartner Z, Abate AR. Compact and modular multicolour fluorescence detector for droplet microfluidics. Lab Chip. 2015 Jul 7; 15(13):2754-8. PMID: 26032595; PMCID: PMC4505729.
    19. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner Z. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92. PMID: 25633040; PMCID: PMC4343104.
    20. Cerchiari A, Garbe JC, Todhunter ME, Jee NY, Pinney JR, LaBarge MA, Desai TA, Gartner Z. Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding. Tissue Eng Part C Methods. 2015 Jun; 21(6):541-7. PMID: 25351430; PMCID: PMC4442595 [Available on 06/01/16].
    21. Weber RJ, Liang SI, Selden NS, Desai TA, Gartner Z. Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly. Biomacromolecules. 2014 Dec 8; 15(12):4621-6. PMID: 25325667; PMCID: PMC4261982.
    22. Seo D, Farlow J, Southard K, Jun YW, Gartner Z. Production and targeting of monovalent quantum dots. J Vis Exp. 2014; (92):e52198. PMID: 25407345; PMCID: PMC4309134.
    23. Liang SI, McFarland JM, Rabuka D, Gartner Z. A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds. J Am Chem Soc. 2014 Aug 6; 136(31):10850-3. PMID: 25029632; PMCID: PMC4132959.
    24. Rosenblatt J, Gartner Z. Cells: Shaping tissues and organs. Mol Biol Cell. 2014 Mar; 25(6):730. PMID: 24626844; PMCID: PMC3952838.
    25. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner Z, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5. PMID: 24122039; PMCID: PMC3968776.
    26. Sogi KM, Gartner Z, Breidenbach MA, Appel MJ, Schelle MW, Bertozzi CR. Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. PLoS One. 2013; 8(6):e65080. PMID: 23762287; PMCID: PMC3675115.
    27. Liu JS, Gartner Z. Directing the assembly of spatially organized multicomponent tissues from the bottom up. Trends Cell Biol. 2012 Dec; 22(12):683-91. PMID: 23067679; PMCID: PMC3505240.
    28. Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner Z. Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis. Cell Rep. 2012 Nov 29; 2(5):1461-70. PMID: 23041312; PMCID: PMC3634587.
    29. Onoe H, Hsiao SC, Douglas ES, Gartner Z, Bertozzi CR, Francis MB, Mathies RA. Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences. Langmuir. 2012 May 29; 28(21):8120-6. PMID: 22512362.
      View in: PubMed
    30. Selden NS, Todhunter ME, Jee NY, Liu JS, Broaders KE, Gartner Z. Chemically programmed cell adhesion with membrane-anchored oligonucleotides. J Am Chem Soc. 2012 Jan 18; 134(2):765-8. PMID: 22176556; PMCID: PMC3280587.
    31. Hsiao SC, Shum BJ, Onoe H, Douglas ES, Gartner Z, Mathies RA, Bertozzi CR, Francis MB. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir. 2009 Jun 16; 25(12):6985-91. PMID: 19505164; PMCID: PMC2812030.
    32. Gartner Z, Bertozzi CR. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4606-10. PMID: 19273855; PMCID: PMC2660766.
    33. Chen X, Wu P, Rousseas M, Okawa D, Gartner Z, Zettl A, Bertozzi CR. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc. 2009 Jan 28; 131(3):890-1. PMID: 19119844; PMCID: PMC2657038.
    34. Gartner Z, Tse BN, Grubina R, Doyon JB, Snyder TM, Liu DR. DNA-templated organic synthesis and selection of a library of macrocycles. Science. 2004 Sep 10; 305(5690):1601-5. PMID: 15319493; PMCID: PMC2814051.
    35. Buskirk AR, Ong YC, Gartner Z, Liu DR. Directed evolution of ligand dependence: small-molecule-activated protein splicing. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10505-10. PMID: 15247421; PMCID: PMC489967.
    36. Li X, Gartner Z, Tse BN, Liu DR. Translation of DNA into synthetic N-acyloxazolidines. J Am Chem Soc. 2004 Apr 28; 126(16):5090-2. PMID: 15099091.
      View in: PubMed
    37. Gartner Z, Grubina R, Calderone CT, Liu DR. Two enabling architectures for DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1370-5. PMID: 12671971.
      View in: PubMed
    38. Calderone CT, Puckett JW, Gartner Z, Liu DR. Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2002 Nov 4; 41(21):4104-8. PMID: 12412096.
      View in: PubMed
    39. Gartner Z, Kanan MW, Liu DR. Multistep small-molecule synthesis programmed by DNA templates. J Am Chem Soc. 2002 Sep 4; 124(35):10304-6. PMID: 12197733.
      View in: PubMed
    40. Gartner Z, Kanan MW, Liu DR. Expanding the reaction scope of DNA-templated synthesis. Angew Chem Int Ed Engl. 2002 May 17; 41(10):1796-800. PMID: 19750721.
      View in: PubMed
    41. Gartner Z, Liu DR. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules. J Am Chem Soc. 2001 Jul 18; 123(28):6961-3. PMID: 11448217; PMCID: PMC2820563.
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