James Gardner, MD, PhD
|
Title(s) | Assistant Professor, Surgery |
---|
School | School of Medicine |
---|
Address | 505 Parnassus Avenue San Francisco CA 94143
|
---|
Phone | 415-514-7420 |
---|
vCard | Download vCard |
---|
|
|
Biography Harvard University, Cambridge, MA | AB | 06/2002 | Biochemistry | University of California San Francisco, San Francisco, CA | MD/PhD | 06/2012 | Genetics | University of California San Francisco, San Francisco, CA | Resident | 06/2016 | General Surgery | University of California San Francisco, San Francisco, CA | Chief Resident | 06/2017 | General Surgery | University of California San Francisco, San Francisco, CA | Clinical Instructor and Fellow | 08/2019 | Abdominal Transplant Surgery |
UCSF Dean's Office | 2019
-
| 2024 | Sandler PSSP Grant | American Society of Transplant Surgeons | 2017
-
| 2019 | ASTS-Astellas Fellowship in Transplantation Grant | UCSF Department of Surgery | 2017
-
| 2017 | Nusz Achievement Award | UCSF Division of Trauma and Critical Care | 2016
-
| 2016 | Schecter Award for Senior Trauma Fellow | UCSF Emergency Medicine | 2016
-
| 2016 | ED Surgical Consultant of the Year |
Overview The Gardner lab studies novel mechanisms of immune tolerance and their applications in autoimmunity, transplantation, and cancer immunology. In particular we focus on the biology and function of a unique population of dendritic cells expressing the Autoimmune Regulator (Aire) gene. Previously the lab has shown that by using bacterial artificial chromosome (BAC) transgenesis we could exploit the Aire promoter to drive expression of disease-relevant antigens and transcriptional reporters in mice. Using these tools, we were able to alter thymic negative selection against disease-relevant antigens, but we were also able to identify novel populations of Aire-expressing cells outside the thymus in the secondary and tertiary lymphoid organs - which we called extra-Thymic Aire-expressing Cells (eTACs). We have since gone on to describe some of the fundamental biology and immunology of this population.
We have found that, as in the thymus, Aire in eTACs regulates the expression of an array of tissue-specific antigens, though the set of antigens may be distinct from those expressed in the thymus. Further, we were able to demonstrate that eTACs could form long-term interactions with cognate T cells, and that the result of those interactions was deletional tolerance.
We subsequently demonstrated that eTACs were hematopoietic in origin and members of the dendritic cell family, were highly potent inducers of self-tolerance resistant to both innate inflammatory stimuli and costimulation, and that antigen expression in eTACs was sufficient to prevent insulitis and autoimmune diabetes in a murine adoptive transfer model.
We are currently using multimodal approaches from single-cell RNA-sequencing to ATAC-Seq to novel transgenic tools to understand the biology and immunology of this unique population of cells with significant potential for clinical relevance. We are interested in the role of such tolergenic APCs in normal immune homeostasis, as well as in disease-relevant applications from transplantation to tumor immunity.
ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
-
Transplantation From Older Donors: Can Senolytics Turn Back the Clock? Transplantation. 2021 Apr 01; 105(4):681-682.
Dixon W, Feng S, Gardner J. PMID: 33760787.
View in: PubMed Mentions: Fields:
-
Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096.
Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV. PMID: 33597545.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
-
Surgical, Interventional, and Medical Palliation of Portal Hypertension. Am Surg. 2020 Nov 06; 3134820965947.
Lin JA, Gardner JM, Kolli KP, Cook AC. PMID: 33153284.
View in: PubMed Mentions: Fields: Translation: Humans
-
CON: Portal Vein Thrombosis Does Not Impact Liver Transplantation Outcomes. Clin Liver Dis (Hoboken). 2020 Oct; 16(4):132.
Sherman C, Syed S, Gardner J, Yao FY. PMID: 33163163.
View in: PubMed Mentions:
-
COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions. Transplantation. 2020 11; 104(11):2215-2220.
Syed SM, Gardner J, Roll G, Webber A, Mehta N, Shoji J, Adelmann D, Niemann C, Braun HJ, Mello A, Yao F, Posselt A, Kang SM, Hirose R, Roberts J, Feng S, Ascher N, Stock P, Freise C. PMID: 32639408.
View in: PubMed Mentions: Fields: Translation: HumansCellsPHPublic Health
-
Curr Hepatology Rep. Non-selective Beta-Blockers in Decompensated Cirrhosis. 2020.
Huang, A.C., Gardner, J.M. & Hameed, B. View Publication.
-
Ethical Issues in the COVID Era: Doing the Right Thing Depends on Location, Resources, and Disease Burden. Transplantation. 2020 07; 104(7):1316-1320.
Stock PG, Wall A, Gardner J, Domínguez-Gil B, Chadban S, Muller E, Dittmer I, Tullius SG. PMID: 32569002.
View in: PubMed Mentions: Fields: Translation: HumansCellsPHPublic Health
-
Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence. Am J Transplant. 2017 Sep; 17(9):2444-2450.
Wisel SA, Gardner JM, Roll GR, Harbell J, Freise CE, Feng S, Kang SM, Hirose R, Kaufman DB, Posselt AM, Stock PG. PMID: 28489277.
View in: PubMed Mentions: 1 Fields: Translation: Humans
-
Effect of intratonsillar injection of steroids on the palatine tonsils of rabbits. Laryngoscope. 2014 Dec; 124(12):2811-7.
Cho DY, Sinha SR, Gardner JM, Schaller MP, Pamnani RD, Felt SA, Barral JK, Messner AH. PMID: 24114886.
View in: PubMed Mentions: 1 Fields: Translation: Animals
-
Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17; 5(1):166-79.
Metzger TC, Khan IS, Gardner JM, Mouchess ML, Johannes KP, Krawisz AK, Skrzypczynska KM, Anderson MS. PMID: 24095736.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
-
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72.
Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. PMID: 23993652.
View in: PubMed Mentions: 42 Fields: Translation: AnimalsCells
-
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012 Sep 24; 209(10):1713-22, S1-19.
Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA. PMID: 22966003.
View in: PubMed Mentions: 263 Fields: Translation: AnimalsCells
-
Immunoendocrinology: Scientific and Clinical Aspects. Eisenbarth, GS (Ed.). The Mouse Model of Autoimmune Polyglandular Syndrome Type I. 2011; 1(1):95-113.
Gardner JM, Anderson MA.
-
AIRE in the thymus and beyond. Curr Opin Immunol. 2009 Dec; 21(6):582-9.
Gardner JM, Fletcher AL, Anderson MS, Turley SJ. PMID: 19833494.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
-
The sickness unto Deaf. Nat Immunol. 2009 Sep; 10(9):934-6.
Gardner JM, Anderson MS. PMID: 19692991.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
-
Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7.
Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. PMID: 18687966.
View in: PubMed Mentions: 189 Fields: Translation: AnimalsCells
-
Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1346-52.
Lewinsohn DA, Heinzel AS, Gardner JM, Zhu L, Alderson MR, Lewinsohn DM. PMID: 12969871.
View in: PubMed Mentions: 52 Fields: Translation: HumansCells
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year | Publications |
---|
2003 | 1 | 2008 | 1 | 2009 | 2 | 2011 | 1 | 2012 | 1 | 2013 | 2 | 2014 | 1 | 2017 | 1 | 2020 | 5 | 2021 | 2 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
newest
oldest
line numbers
double spacing
all authors
publication IDs
|
Derived automatically from this person's publications.
_
People in Profiles who have published with this person.
_
People who share similar concepts with this person.
_
Search Department
_
|