Ophir Klein, PhD, MD

Title(s)Professor, Orofacial Sciences
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSE, #001
San Francisco CA 94143
Phone415-502-2517
ORCID ORCID Icon0000-0002-6254-7082 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoGenetics residency2007School of Medicine
    Yale UniversityPediatrics residency2003School of Medicine
    Yale UniversityM.D.2000School of Medicine
    Yale UniversityPh.D.1999School of Medicine
    University of California, BerkeleyB.A.1993
    Collapse Awards and Honors
    2021Elected member, Association of American Physicians
    2020Dr. Richard and Nancy Christiansen Craniofacial Research and Education Lecturer, University of Minne
    2018Elected member, National Academy of Medicine
    2017Lawrence A. Tabak Lecturership, University of Rochester
    2017Craniofacial Biology Distinguished Scientist Award, International Association for Dental Research
    2016Inaugural Sustaining Outstanding Achievement in Research (SOAR) R35 Award, NIDCR
    2016Charles J. Epstein Professor of Human Genetics
    2021Rachford Lecturer, Cincinnati Children’s Hospital Medical Center
    2015Faculty Research Lecturer Award, UCSF School of Dentistry
    2015E. Mead Johnson Award, Society for Pediatric Research
    2014Fellow, American Association for the Advancement of Science (AAAS)
    2014Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies
    2013Outstanding Faculty Mentorship Award, UCSF Graduate Students' Association
    2013Elected Member, American Society for Clinical Investigation
    2013Physician Scientist Award, California Institute of Regenerative Medicine
    2010New Innovator Award, National Institutes of Health
    2009Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research
    2009Elected Member, Western Society for Pediatric Research
    2009Basil O'Connor Award, March of Dimes
    2008Elected Member, Society for Pediatric Research
    2008New Faculty Award, California Institute of Regenerative Medicine
    2008Charles E. Culpeper Scholar, Goldman Philanthropic Partnerships
    2008Young Investigator, United States Bone and Joint Decade
    2005Young Investigator Research Grant Award, American Academy of Pediatrics Section on Genetics and Birt
    2005Fellow Research Award, Society for Pediatric Research
    2005David W. Smith Research Award, Western Society for Pediatric Research
    2004Fellow, Pediatric Scientist Development Program, NICHD
    2004Fellow, American Academy of Pediatrics
    1999Dean's Distinguished Thesis Commendation, Yale University Graduate School
    1993Medical Scientist Training Program, National Institutes of Health
    1989Chancellor's Scholarship, University of California, Berkeley

    Collapse Overview 
    Collapse Overview
    Ophir Klein is Professor of Orofacial Sciences and Pediatrics, the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, and the Charles J. Epstein Professor of Human Genetics at the University of California, San Francisco (UCSF). He serves as Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, Interim Director of the Institute for Human Genetics, and Director of the Program in Craniofacial Biology.
    The Klein laboratory focuses on understanding how organs form in developing embryos and how they regenerate in adults. When developmental and regenerative processes go awry, then birth defects, cancer and other diseases can result. The group's research is centered on understanding how development and regeneration normally occur in the hope of one day treating diseases that result from abnormalities in these processes.
    A central focus in the lab is craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. The maintenance, repair and growth of many adult organs, such as the bone marrow, skin, brain, and gastrointestinal tract, depend on tissue-specific populations of stem cells. The lab uses the rodent incisor, which grows continuously throughout the life of the animal, as a model system to understand adult stem cells. We intend to use the insights provided by our experiments in mice to guide us in the use of stem cells in regenerating dental and craniofacial tissues as a paradigm for developing replacement organs.
    Another major area of study is regeneration of the gastrointestinal tract. The amazing ability of the mammalian gastrointestinal epithelium to renew has long fascinated biologists. Our research aims to address fundamental questions in this field, including the identity, regulation and plasticity of intestinal stem cells.
    Finally, the laboratory is interested in how positive and negative modulators of signaling affect development, homeostasis and cancer. We are studying the roles of these molecules in the patterning and outgrowth of teeth, taste papillae, the oral mucosa, and other tissues and organs.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Enamel atlas: systems-level amelogenesis tools at multiple scales
    NIH UH3DE028872Aug 1, 2021 - Jul 31, 2024
    Role: Principal Investigator
    Using human intestinal organoids to model IBD pathogenesis
    NIH R21DK127206Sep 16, 2020 - Aug 31, 2022
    Role: Principal Investigator
    The physical and molecular mechanisms of intestinal villus morphogenesis and repair
    NIH R01DK126376Sep 15, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Enamel atlas: systems-level amelogenesis tools at multiple scales
    NIH UG3DE028872Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Cellular and molecular control of tooth morphogenesis
    NIH R01DE028496Jul 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Functional Molecular Investigation of Inflammatory Bowel Disease (IBD) Risk Variants
    NIH R01DK119979Sep 18, 2018 - May 31, 2022
    Role: Co-Principal Investigator
    Regulation of organogenesis through regional variations in tissue mechanics
    NIH R01DE027620Mar 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    2018 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar
    NIH R13DE027575Jan 1, 2018 - Dec 31, 2018
    Role: Principal Investigator
    Using human intestinal organoids to model IBD pathogenesis
    The Kenneth Rainin Foundation Innovator Award 2017-281Oct 1, 2017 - Sep 30, 2018
    Role: Principal Investigator
    Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH/NIDCR U24DE026914Mar 1, 2017 - Feb 28, 2020
    Role: Co-Principal Investigator
    The role of stem cell competition in precancerous field formation
    UCSF UCSF Resource Allocation ProgramJan 1, 2017 - Dec 31, 2017
    Role: Principal Investigator
    Harnessing natural stem cell-based strategies for mammalian dental renewal
    NIH R35DE026602Sep 22, 2016 - Jun 30, 2024
    Role: Principal Investigator
    2016 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar
    NIH R13DE025777Jan 19, 2016 - Jan 18, 2017
    Role: Principal Investigator
    Systems morphogenesis of tooth development
    The Royal Society IE150381Nov 1, 2015 - Oct 31, 2017
    Role: Principal Investigator
    University of California Tissue Regeneration Resource Center (UCTRRC)
    NIH R34DE025592Sep 8, 2015 - Aug 31, 2016
    Role: Co-Principal Investigator
    The role of Hippo and YAP/TAZ in dental renewal
    NIH R01DE024988Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironment
    NIH U01DK103147Sep 5, 2014 - Aug 31, 2024
    Role: Principal Investigator
    Developing 3D Craniofacial Morphometry Data and Tools to Transform Dysmorphology
    NIH U01DE024440May 16, 2014 - Apr 30, 2020
    Role: Co-Principal Investigator
    Stem cell therapy for inflammatory bowel disease
    California Institute of Rgenerative Medicine RN3-06525Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    The role of Sprouty genes in development of mammalian external genitalia
    NIH R01DK095002Sep 18, 2012 - Aug 31, 2014
    Role: Principal Investigator
    The role of Bmi1 in regulation of dental stem cells
    NIH R01DE021420Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    An evolutionary-developmental approach to stem cells using teeth as a model
    NIH DP2OD007191Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    The role of Sprouty genes in development of the circumvallate papilla
    NIH R21DC011108Jul 6, 2010 - Jun 30, 2012
    Role: Principal Investigator
    The role of Spry2 in regulation of bone formation
    NIH R03AR057121Apr 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    The Role of microRNAs in Tooth Regeneration using the Mouse Incisor Model
    NIH R21DE019958Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Analysis of the Role of Sprouty Genes in Tooth Development
    NIH K08DE017654Jul 1, 2007 - Jun 30, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement. PLoS Genet. 2024 Jun; 20(6):e1011326. Du W, Verma A, Ye Q, Du W, Lin S, Yamanaka A, Klein OD, Hu JK. PMID: 38857279; PMCID: PMC11192418.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Mapping genes for human face shape: exploration of univariate phenotyping strategies. bioRxiv. 2024 Jun 07. Yuan M, Goovaerts S, Vanneste M, Matthews H, Hoskens H, Richmond S, Klein OD, Spritz RA, Hallgrimsson B, Walsh S, Shriver MD, Shaffer JR, Weinberg SM, Peeters H, Claes P. PMID: 38895298; PMCID: PMC11185724.
      View in: PubMed   Mentions:
    3. Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024 Jun 06; 187(12):3072-3089.e20. Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. PMID: 38781967; PMCID: PMC11166531.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy. Cancer Discov. 2024 May 14. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Oberheim Bush NA, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. PMID: 38742767.
      View in: PubMed   Mentions: 1     Fields:    
    5. Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer. Cell Death Dis. 2024 Apr 10; 15(4):256. Li J, Ma R, Wang X, Lu Y, Chen J, Feng D, Zhou J, Xia K, Klein O, Xie H, Lu P. PMID: 38600092; PMCID: PMC11006910.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nat Cell Biol. 2024 Apr 03. Shroff NP, Xu P, Kim S, Shelton ER, Gross BJ, Liu Y, Gomez CO, Ye Q, Drennon TY, Hu JK, Green JBA, Campàs O, Klein OD. PMID: 38570617.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. 2023 ASHG Lifetime Achievement Award: Neil Risch. Am J Hum Genet. 2024 Mar 07; 111(3):410-411. Klein O. PMID: 38458161; PMCID: PMC10995462.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2):250-262. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 38321203.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    9. MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis. bioRxiv. 2024 Feb 05. Graham AJ, Khoo MWL, Srivastava V, Viragova S, Parekh K, Morley CD, Bird M, Lebel P, Kumar S, Klein O, Gómez-Sjöberg R, Gartner ZJ. PMID: 38370663; PMCID: PMC10871257.
      View in: PubMed   Mentions:
    10. An interactive atlas of three-dimensional syndromic facial morphology. Am J Hum Genet. 2024 Jan 04; 111(1):39-47. Aponte JD, Bannister JJ, Hoskens H, Matthews H, Katsura K, Da Silva C, Cruz T, Pilz JHM, Spritz RA, Forkert ND, Claes P, Bernier FP, Klein OD, Katz DC, Hallgrímsson B. PMID: 38181734; PMCID: PMC10806736.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Conserved and derived expression patterns and positive selection on dental genes reveal complex evolutionary context of ever-growing rodent molars. bioRxiv. 2023 Dec 18. Calamari ZT, Song A, Cohen E, Akter M, Roy RD, Hallikas O, Christensen MM, Li P, Marangoni P, Jernvall J, Klein OD. PMID: 38187646; PMCID: PMC10769287.
      View in: PubMed   Mentions:
    12. Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population. bioRxiv. 2023 Dec 08. Vanneste M, Hoskens H, Goovaerts S, Matthews H, Aponte JD, Cole J, Shriver M, Marazita ML, Weinberg SM, Walsh S, Richmond S, Klein OD, Spritz RA, Peeters H, Hallgrímsson B, Claes P. PMID: 38106188; PMCID: PMC10723447.
      View in: PubMed   Mentions:
    13. Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral. Int J Oral Sci. 2023 Dec 07; 15(1):55. Kim HY, Cooley V, Kim EJ, Li S, Lee JM, Sheyfer D, Liu W, Klein OD, Joester D, Jung HS. PMID: 38062012; PMCID: PMC10703793.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution. Res Sq. 2023 Oct 27. Gutkind JS, Faraji F, Ramirez S, Clubb L, Sato K, Quiroz PA, Galloway W, Mikulski Z, Hoang T, Medetgul-Ernar K, Marangoni P, Jones K, Officer A, Molinolo A, Kim K, Sakaguchi K, Califano J, Smith Q, Klein O, Tamayo P. PMID: 37961717; PMCID: PMC10635308.
      View in: PubMed   Mentions:
    15. Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis. J Clin Invest. 2023 10 16; 133(20). Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD. PMID: 37643009; PMCID: PMC10575728.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†. Biol Reprod. 2023 10 13; 109(4):533-551. Luo Y, Yamada M, N'Tumba-Byn T, Asif H, Gao M, Hu Y, Marangoni P, Liu Y, Evans T, Rafii S, Klein OD, Voss HU, Hadjantonakis AK, Elemento O, Martin LA, Seandel M. PMID: 37552049; PMCID: PMC10577279.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. bioRxiv. 2023 Sep 22. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 37790430; PMCID: PMC10542170.
      View in: PubMed   Mentions:
    18. Bcl-6 expression by CD4+ T cells determines concomitant immunity and host resistance across distinct parasitic infections. Mucosal Immunol. 2023 12; 16(6):801-816. Meli AP, Russell GA, Swaminathan S, Weichselbaum L, MacMahon CA, Pernet E, Karo-Atar D, Rogers D, Rochette A, Fontes G, Mandl JN, Divangahi M, Klein OD, Gregorieff A, Stäger S, King IL. PMID: 37659724.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023 Aug 15. Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ. PMID: 37425793; PMCID: PMC10326967.
      View in: PubMed   Mentions:
    20. Direct reprogramming of oral epithelial progenitor cells to cancer stem cells at single cell resolution in vivo. bioRxiv. 2023 Jul 26. Faraji F, Ramirez SI, Clubb LM, Sato K, Quiroz PYA, Galloway WMG, Mikulski Z, Hoang TS, Medetgul-Ernar K, Marangoni P, Jones KB, Officer A, Molinolo AA, Kim K, Sakaguchi K, Califano JA, Smith Q, Klein OD, Tamayo P, Gutkind JS. PMID: 37546810; PMCID: PMC10402053.
      View in: PubMed   Mentions:
    21. Reconnecting, Recommitting, and Renewing. J Dent Res. 2023 09; 102(10):1078-1079. Klein OD. PMID: 37465936.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy. bioRxiv. 2023 Jul 11. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. PMID: 37503127; PMCID: PMC10369862.
      View in: PubMed   Mentions:
    23. Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses. Sci Data. 2023 Jun 28; 10(1):420. Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B. PMID: 37380661; PMCID: PMC10307867.
      View in: PubMed   Mentions:    Fields:    
    24. Intracellular pH dynamics regulates intestinal stem cell lineage specification. Nat Commun. 2023 06 23; 14(1):3745. Liu Y, Reyes E, Castillo-Azofeifa D, Klein OD, Nystul T, Barber DL. PMID: 37353491; PMCID: PMC10290085.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. The developmental basis for scaling of mammalian tooth size. Proc Natl Acad Sci U S A. 2023 06 20; 120(25):e2300374120. Christensen MM, Hallikas O, Das Roy R, Väänänen V, Stenberg OE, Häkkinen TJ, François JC, Asher RJ, Klein OD, Holzenberger M, Jernvall J. PMID: 37307487; PMCID: PMC10288632.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Precise modulation of transcription factor levels identifies features underlying dosage sensitivity. Nat Genet. 2023 05; 55(5):841-851. Naqvi S, Kim S, Hoskens H, Matthews HS, Spritz RA, Klein OD, Hallgrímsson B, Swigut T, Claes P, Pritchard JK, Wysocka J. PMID: 37024583; PMCID: PMC10181932.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    27. Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition. bioRxiv. 2023 Apr 04. Griffin MF, Talbott HE, Guardino NJ, Guo JL, Spielman AF, Chen K, Parker JBL, Mascharak S, Henn D, Liang N, King M, Cotterell AC, Bauer-Rowe KE, Abbas DB, Diaz Deleon NM, Sivaraj D, Fahy EJ, Downer M, Akras D, Berry C, Cook J, Quarto N, Klein OD, Lorenz HP, Gurtner GC, Januszyk M, Wan DC, Longaker MT. PMID: 37066136; PMCID: PMC10103999.
      View in: PubMed   Mentions:
    28. A Suite of Mouse Reagents for Studying Amelogenesis. bioRxiv. 2023 Apr 02. Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD. PMID: 37034814; PMCID: PMC10081212.
      View in: PubMed   Mentions:
    29. EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids. JCI Insight. 2023 03 22; 8(6). Childs CJ, Holloway EM, Sweet CW, Tsai YH, Wu A, Vallie A, Eiken MK, Capeling MM, Zwick RK, Palikuqi B, Trentesaux C, Wu JH, Pellón-Cardenas O, Zhang CJ, Glass I, Loebel C, Yu Q, Camp JG, Sexton JZ, Klein OD, Verzi MP, Spence JR. PMID: 36821371; PMCID: PMC10070114.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Privacy, bias and the clinical use of facial recognition technology: A survey of genetics professionals. Am J Med Genet C Semin Med Genet. 2023 09; 193(3):e32035. Aboujaoude E, Light J, Brown JEH, Boscardin WJ, Hallgrímsson B, Klein OD. PMID: 36751120; PMCID: PMC10578447.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Comparing 2D and 3D representations for face-based genetic syndrome diagnosis. Eur J Hum Genet. 2023 09; 31(9):1010-1016. Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FP, Spritz RA, Hallgrímsson B, Forkert ND. PMID: 36750664; PMCID: PMC10474012.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell. 2023 02 02; 30(2):188-206.e6. Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD. PMID: 36640764; PMCID: PMC9922544.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    33. Harnessing synthetic biology to engineer organoids and tissues. Cell Stem Cell. 2023 01 05; 30(1):10-19. Trentesaux C, Yamada T, Klein OD, Lim WA. PMID: 36608674.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    34. Programming multicellular assembly with synthetic cell adhesion molecules. Nature. 2023 02; 614(7946):144-152. Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA. PMID: 36509107; PMCID: PMC9892004.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    35. Editorial overview: How to generate and maintain organs-organoids, regeneration, and beyond. Curr Opin Genet Dev. 2022 Dec; 77:102003. Klein OD, Nishinakamura R. PMID: 36368183.
      View in: PubMed   Mentions: 1     Fields:    
    36. Detecting 3D syndromic faces as outliers using unsupervised normalizing flow models. Artif Intell Med. 2022 12; 134:102425. Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND. PMID: 36462895; PMCID: PMC10949379.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Cellular shape reinforces niche to stem cell signaling in the small intestine. Sci Adv. 2022 Oct 14; 8(41):eabm1847. Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P. PMID: 36240269; PMCID: PMC9565803.
      View in: PubMed   Mentions: 5     Fields:    
    38. A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes. Cell Mol Life Sci. 2022 Sep 13; 79(10):514. Altés G, Vaquero M, Cuesta S, Anerillas C, Macià A, Espinet C, Ribera J, Bellusci S, Klein OD, Yeramian A, Dolcet X, Egea J, Encinas M. PMID: 36098804; PMCID: PMC9470706.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    39. Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury. Cell Stem Cell. 2022 08 04; 29(8):1262-1272.e5. Palikuqi B, Rispal J, Reyes EA, Vaka D, Boffelli D, Klein O. PMID: 35931034; PMCID: PMC9387209.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    40. Refining nosology by modelling variation among facial phenotypes: the RASopathies. J Med Genet. 2022 Jul 20. Matthews H, Vanneste M, Katsura K, Aponte D, Patton M, Hammond P, Baynam G, Spritz R, Klein OD, Hallgrimsson B, Peeters H, Claes P. PMID: 35858754; PMCID: PMC9852361.
      View in: PubMed   Mentions:    Fields:    
    41. A Deep Invertible 3-D Facial Shape Model for Interpretable Genetic Syndrome Diagnosis. IEEE J Biomed Health Inform. 2022 07; 26(7):3229-3239. Bannister JJ, Wilms M, Aponte JD, Katz DC, Klein OD, Bernier FPJ, Spritz RA, Hallgrimsson B, Forkert ND. PMID: 35380975; PMCID: PMC9429803.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    42. Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration. Cold Spring Harb Perspect Biol. 2022 05 27; 14(5). Palikuqi B, Rispal J, Klein O. PMID: 34580119; PMCID: PMC9159262.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses. Sci Data. 2022 05 25; 9(1):230. Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B. PMID: 35614082; PMCID: PMC9133120.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    44. CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids. Nat Commun. 2022 05 03; 13(1):2407. Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD. PMID: 35504891; PMCID: PMC9065090.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    45. Parallels in signaling between development and regeneration in ectodermal organs. Curr Top Dev Biol. 2022; 149:373-419. Pincha N, Marangoni P, Haque A, Klein OD. PMID: 35606061; PMCID: PMC10049776.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    46. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5). Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. PMID: 35077396; PMCID: PMC8884902.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    47. SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal. Dev Cell. 2022 03 14; 57(5):624-637.e4. Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD. PMID: 35202586; PMCID: PMC8974236.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    48. LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland. Cell Rep. 2022 02 15; 38(7):110375. Ma R, Gong D, You H, Xu C, Lu Y, Bergers G, Werb Z, Klein OD, Petritsch CK, Lu P. PMID: 35172155; PMCID: PMC9113222.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model. Dis Model Mech. 2022 02 01; 15(2). Tidyman WE, Goodwin AF, Maeda Y, Klein OD, Rauen KA. PMID: 34553752; PMCID: PMC8617311.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    50. Publisher Correction: Application of full-genome analysis to diagnose rare monogenic disorders. NPJ Genom Med. 2021 Oct 12; 6(1):88. Shieh JT, Penon-Portmann M, Wong KHY, Levy-Sakin M, Verghese M, Slavotinek A, Gallagher RC, Mendelsohn BA, Tenney J, Beleford D, Perry H, Chow SK, Sharo AG, Brenner SE, Qi Z, Yu J, Klein OD, Martin D, Kwok PY, Boffelli D. PMID: 34642307; PMCID: PMC8511154.
      View in: PubMed   Mentions:
    51. Application of full-genome analysis to diagnose rare monogenic disorders. NPJ Genom Med. 2021 Sep 23; 6(1):77. Shieh JT, Penon-Portmann M, Wong KHY, Levy-Sakin M, Verghese M, Slavotinek A, Gallagher RC, Mendelsohn BA, Tenney J, Beleford D, Perry H, Chow SK, Sharo AG, Brenner SE, Qi Z, Yu J, Klein OD, Martin D, Kwok PY, Boffelli D. PMID: 34556655; PMCID: PMC8460793.
      View in: PubMed   Mentions: 15  
    52. Salivary gland: A budding genius. Dev Cell. 2021 08 23; 56(16):2271-2272. Cazares O, Haque AS, Klein OD. PMID: 34428396.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    53. Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development. Development. 2021 07 15; 148(14). Kim R, Yu T, Li J, Prochazka J, Sharir A, Green JBA, Klein OD. PMID: 34195802; PMCID: PMC8326921.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Large-scale open-source three-dimensional growth curves for clinical facial assessment and objective description of facial dysmorphism. Sci Rep. 2021 06 09; 11(1):12175. Matthews HS, Palmer RL, Baynam GS, Quarrell OW, Klein OD, Spritz RA, Hennekam RC, Walsh S, Shriver M, Weinberg SM, Hallgrimsson B, Hammond P, Penington AJ, Peeters H, Claes PD. PMID: 34108542; PMCID: PMC8190313.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    55. Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids. Cell Stem Cell. 2021 09 02; 28(9):1516-1532.e14. Tallapragada NP, Cambra HM, Wald T, Keough Jalbert S, Abraham DM, Klein OD, Klein AM. PMID: 33915079; PMCID: PMC8419000.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    56. Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Dev Cell. 2021 02 08; 56(3):356-365.e9. Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ. PMID: 33484640; PMCID: PMC7917018.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    57. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21). Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679; PMCID: PMC7710308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    58. Engineering synthetic morphogen systems that can program multicellular patterning. Science. 2020 10 16; 370(6514):327-331. Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA. PMID: 33060357; PMCID: PMC7986291.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    59. Asymmetric Stratification-Induced Polarity Loss and Coordinated Individual Cell Movements Drive Directional Migration of Vertebrate Epithelium. Cell Rep. 2020 10 13; 33(2):108246. Lu Y, Deng R, You H, Xu Y, Antos C, Sun J, Klein OD, Lu P. PMID: 33053348; PMCID: PMC7668195.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    60. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun. 2020 09 23; 11(1):4816. Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves VCM, Yianni V, Sharpe PT, Harkany T, Metscher BD, Bajénoff M, Mina M, Fried K, Kharchenko PV, Adameyko I. PMID: 32968047; PMCID: PMC7511944.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    61. FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research. Development. 2020 09 21; 147(18). Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. PMID: 32958507; PMCID: PMC7522026.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    62. Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions. J Dent Res. 2020 11; 99(12):1397-1405. Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA. PMID: 32674684; PMCID: PMC7580171.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    63. FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 07 14; 18(1):87. Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X. PMID: 32664967; PMCID: PMC7359594.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    64. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. J Dent Res. 2020 11; 99(12):1387-1396. Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD. PMID: 32623954; PMCID: PMC7580170.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    65. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. BMC Cancer. 2020 Jun 10; 20(1):542. Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V. PMID: 32522170; PMCID: PMC7285764.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    66. Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images. Sensors (Basel). 2020 Jun 03; 20(11). Bannister JJ, Crites SR, Aponte JD, Katz DC, Wilms M, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND. PMID: 32503190; PMCID: PMC7309125.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    67. Automated syndrome diagnosis by three-dimensional facial imaging. Genet Med. 2020 10; 22(10):1682-1693. Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, Chatfield KC, Davis SM, Elias ER, Enzenauer RW, French BM, Pickler LL, Shieh JTC, Slavotinek A, Harrop AR, Innes AM, McCandless SE, McCourt EA, Meeks NJL, Tartaglia NR, Tsai AC, Wyse JPH, Bernstein JA, Sanchez-Lara PA, Forkert ND, Bernier FP, Spritz RA, Klein OD. PMID: 32475986; PMCID: PMC7521994.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    68. Tools and Concepts for Interrogating and Defining Cellular Identity. Cell Stem Cell. 2020 05 07; 26(5):632-656. McKinley KL, Castillo-Azofeifa D, Klein OD. PMID: 32386555; PMCID: PMC7250495.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    69. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community. G3 (Bethesda). 2020 05 04; 10(5):1503-1510. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. PMID: 32152007; PMCID: PMC7202022.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    70. Safety and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects. Br J Clin Pharmacol. 2020 10; 86(10):2063-2069. Körber I, Klein OD, Morhart P, Faschingbauer F, Grange DK, Clarke A, Bodemer C, Maitz S, Huttner K, Kirby N, Durand C, Schneider H. PMID: 32250462; PMCID: PMC7495278.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    71. Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020 04 22; 11(1):1936. Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel M, Itzkovitz S. PMID: 32321913; PMCID: PMC7176679.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    72. From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells. Curr Opin Cell Biol. 2020 04; 63:88-101. Trentesaux C, Striedinger K, Pomerantz JH, Klein OD. PMID: 32036295; PMCID: PMC7247951.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Molecular and cellular mechanisms of tooth development, homeostasis and repair. Development. 2020 01 24; 147(2). Yu T, Klein OD. PMID: 31980484; PMCID: PMC6983727.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    74. Generation of Knockout Gene-Edited Human Intestinal Organoids. Methods Mol Biol. 2020; 2171:215-230. Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD. PMID: 32705644; PMCID: PMC8086508.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    75. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell. 2019 12 05; 25(6):814-829.e6. Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. PMID: 31809739; PMCID: PMC6925542.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    76. Use of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G845-G852. Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MK. PMID: 31589468; PMCID: PMC7132322.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    77. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 09; 21(9):1102-1112. Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. PMID: 31481792; PMCID: PMC6935352.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    78. Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar. JBMR Plus. 2019 Aug; 3(8):e10205. Marangoni P, Charles C, Ahn Y, Seidel K, Jheon A, Ganss B, Krumlauf R, Viriot L, Klein OD. PMID: 31485553; PMCID: PMC6715786.
      View in: PubMed   Mentions: 2  
    79. Case Report of Floating-Harbor Syndrome With Bilateral Cleft Lip. Cleft Palate Craniofac J. 2020 01; 57(1):132-136. Ko J, Pomerantz JH, Perry H, Shieh JT, Slavotinek AM, Oberoi S, Klein OD. PMID: 31248274.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    80. Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development. Int J Mol Sci. 2019 May 08; 20(9). El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. PMID: 31072004; PMCID: PMC6540044.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    81. The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting. Am J Med Genet A. 2019 05; 179(5):864-869. Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. PMID: 30793834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    82. Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration. EMBO J. 2019 02 15; 38(4). Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. PMID: 30635334; PMCID: PMC6376326.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    83. Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium. Am J Physiol Gastrointest Liver Physiol. 2019 02 01; 316(2):G247-G250. Wang TC, Martin MG, Kuo CJ, Klein OD, Niland J. PMID: 30548077.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    84. Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila. Am J Physiol Gastrointest Liver Physiol. 2019 03 01; 316(3):G313-G322. Zwick RK, Ohlstein B, Klein OD. PMID: 30543448; PMCID: PMC6415738.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    85. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 2019 01 15; 38(2). Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B. PMID: 30523147; PMCID: PMC6331727.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    86. Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells. Cell Stem Cell. 2019 01 03; 24(1):183-192.e8. Jones KB, Furukawa S, Marangoni P, Ma H, Pinkard H, D'Urso R, Zilionis R, Klein AM, Klein OD. PMID: 30472156; PMCID: PMC6320295.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    87. Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development. Front Genet. 2018; 9:542. Prochazkova M, Prochazka J, Marangoni P, Klein OD. PMID: 30505318; PMCID: PMC6250787.
      View in: PubMed   Mentions: 19  
    88. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 11 05; 145(21). May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. PMID: 30305288; PMCID: PMC6240316.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    89. Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function. Bioessays. 2018 12; 40(12):e1800140. Calamari ZT, Hu JK, Klein OD. PMID: 30387177; PMCID: PMC6516060.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    90. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature. 2018 11; 563(7732):514-521. Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT. PMID: 30356216; PMCID: PMC6481292.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    91. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. PMID: 30305617; PMCID: PMC6180039.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    92. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 10; 562(7727):E22. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. PMID: 30013120.
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    93. The intestinal epithelial response to damage. Sci China Life Sci. 2018 Oct; 61(10):1205-1211. Weichselbaum L, Klein OD. PMID: 30194677.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    94. Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2160-2173. Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, Pogontke C, Carmona RM, Salvador JM, Perez-Pomares JM, Klein OD, Prósper F, Jimenez-Borreguero LJ, Bernad A. PMID: 29930004; PMCID: PMC6202133.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    95. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018; 3:21. Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D, Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicin. PMID: 30131872; PMCID: PMC6089983.
      View in: PubMed   Mentions: 11  
    96. Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 07 17; 9(1):2854. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. PMID: 30018293; PMCID: PMC6050296.
      View in: PubMed   Mentions: 2     Fields:    
    97. SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 07 17; 145(14). Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. PMID: 29945863; PMCID: PMC6078335.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    98. Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. 2018 Jul 05; 23(1):147. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. PMID: 29979989; PMCID: PMC6039109.
      View in: PubMed   Mentions: 15     Fields:    
    99. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 07; 559(7712):109-113. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. PMID: 29950724; PMCID: PMC6042247.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    100. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. PMID: 29897330; PMCID: PMC6023609.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    101. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 06 13; 9(1):2333. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. PMID: 29899403; PMCID: PMC5998134.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    102. Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care. J Dent Res. 2018 04; 97(4):361-363. Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH. PMID: 29557734; PMCID: PMC5863875.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    103. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. PMID: 29386123; PMCID: PMC5798462.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    104. Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing. Stem Cells. 2018 04; 36(4):562-573. Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F. PMID: 29282831; PMCID: PMC5929111.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    105. Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor. Development. 2018 01 08; 145(1). Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F. PMID: 29180573; PMCID: PMC5825875.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    106. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. Hum Mol Genet. 2018 01 01; 27(1):107-119. Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. PMID: 29126155; PMCID: PMC5886284.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    107. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 01 22; 44(2):165-178.e6. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. PMID: 29290586; PMCID: PMC5826757.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    108. Body size and allometric variation in facial shape in children. Am J Phys Anthropol. 2018 02; 165(2):327-342. Larson JR, Manyama MF, Cole JB, Gonzalez PN, Percival CJ, Liberton DK, Ferrara TM, Riccardi SL, Kimwaga EA, Mathayo J, Spitzmacher JA, Rolian C, Jamniczky HA, Weinberg SM, Roseman CC, Klein O, Lukowiak K, Spritz RA, Hallgrimsson B. PMID: 29178597; PMCID: PMC5777898.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    109. Meeting report: a hard look at the state of enamel research. Int J Oral Sci. 2017 11 22; 9(11):e3. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. PMID: 29165423; PMCID: PMC5775332.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    110. Feedback regulation of RTK signaling in development. Dev Biol. 2019 03 01; 447(1):71-89. Neben CL, Lo M, Jura N, Klein OD. PMID: 29079424; PMCID: PMC5920792.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    111. Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov; 32(11):2219-2231. Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD. PMID: 28650075; PMCID: PMC5685895.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    112. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 09 08; 292(36):15062-15069. Du W, Hu JK, Du W, Klein OD. PMID: 28733464; PMCID: PMC5592681.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    113. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017 Oct; 96(11):1306-1313. Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC. PMID: 28732181; PMCID: PMC5613880.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    114. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul; 13(7):e1006914. El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. PMID: 28715412; PMCID: PMC5536368.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    115. Automatic recognition of the XLHED phenotype from facial images. Am J Med Genet A. 2017 Sep; 173(9):2408-2414. Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK. PMID: 28691769.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    116. Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor. J Dent Res. 2017 Nov; 96(12):1438-1444. Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD. PMID: 28644741; PMCID: PMC5652855.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    117. A review of craniofacial and dental findings of the RASopathies. Orthod Craniofac Res. 2017 Jun; 20 Suppl 1:32-38. Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S. PMID: 28643916; PMCID: PMC5942188.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    118. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017 06 15; 144(12):2212-2221. Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD. PMID: 28506989; PMCID: PMC5482992.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    119. Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis. Elife. 2017 05 05; 6. Seidel K, Marangoni P, Tang C, Houshmand B, Du W, Maas RL, Murray S, Oldham MC, Klein OD. PMID: 28475038; PMCID: PMC5419740.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    120. The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. G3 (Bethesda). 2017 05 05; 7(5):1439-1450. Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B. PMID: 28280213; PMCID: PMC5427488.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    121. An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell. 2017 07 06; 21(1):91-106.e6. Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD. PMID: 28457749; PMCID: PMC5501749.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    122. From snapshots to movies: Understanding early tooth development in four dimensions. Dev Dyn. 2017 06; 246(6):442-450. Kim R, Green JBA, Klein OD. PMID: 28324646; PMCID: PMC5426979.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    123. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. PMID: 28238796; PMCID: PMC5355632.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    124. Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1641-E1650. Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R. PMID: 28196895; PMCID: PMC5338493.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    125. Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann Oncol. 2017 02 01; 28(2):368-376. Menzies AM, Johnson DB, Ramanujam S, Atkinson VG, Wong ANM, Park JJ, McQuade JL, Shoushtari AN, Tsai KK, Eroglu Z, Klein O, Hassel JC, Sosman JA, Guminski A, Sullivan RJ, Ribas A, Carlino MS, Davies MA, Sandhu SK, Long GV. PMID: 27687304.
      View in: PubMed   Mentions: 312     Fields:    Translation:Humans
    126. Human Facial Shape and Size Heritability and Genetic Correlations. Genetics. 2017 02; 205(2):967-978. Cole JB, Manyama M, Larson JR, Liberton DK, Ferrara TM, Riccardi SL, Li M, Mio W, Klein OD, Santorico SA, Hallgrímsson B, Spritz RA. PMID: 27974501; PMCID: PMC5289863.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    127. In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development. 2017 03 15; 144(6):1045-1055. Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD, Spence JR. PMID: 27927684; PMCID: PMC5358103.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    128. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 11 15; 143(22):4115-4126. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. PMID: 27660324; PMCID: PMC5117215.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    129. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 09 12; 214(6):645-7. Sharir A, Klein OD. PMID: 27621361; PMCID: PMC5021101.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    130. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5731-40. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. PMID: 27621461; PMCID: PMC5047180.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    131. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet. 2016 08; 12(8):e1006174. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. PMID: 27560698; PMCID: PMC4999243.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    132. Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. PLoS Genet. 2016 Aug; 12(8):e1006149. Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, Klein O, Mio W, Feingold E, Hallgrimsson B, Spritz RA, Marazita ML, Weinberg SM. PMID: 27560520; PMCID: PMC4999139.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    133. αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 07 13; 7:12133. Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD. PMID: 27405641; PMCID: PMC4947177.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    134. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 Jul 07; 1(10). Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. PMID: 27525310; PMCID: PMC4979554.
      View in: PubMed   Mentions: 7     Fields:    
    135. JCI insight. Dual epithelial and immune cell function of Dvl1 regulates gut mircobiota composition and intestinal homeostasis. 2016; 1(10):e85395. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. View Publication.
    136. Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet. 2016 Oct 01; 25(R2):R86-R93. Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein OD. PMID: 27346519; PMCID: PMC5036869.
      View in: PubMed   Mentions: 6     Fields:    
    137. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 07 15; 143(14):2677-88. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, FaceBase Consortium, Chai Y. PMID: 27287806; PMCID: PMC4958338.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    138. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 07; 88:170-179. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. PMID: 27130872; PMCID: PMC4899137.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    139. Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016 10; 21(10):1417-33. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. PMID: 26830142; PMCID: PMC5685528.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    140. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. PMID: 26740656; PMCID: PMC4701956.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    141. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 03; 20(2):81-7. Du W, Prochazka J, Prochazkova M, Klein OD. PMID: 26748348; PMCID: PMC4842327.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    142. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. PMID: 26702830; PMCID: PMC4710359.
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    143. Development of synovial membrane in the temporomandibular joint of the human fetus. Eur J Histochem. 2015 Nov 26; 59(4):2569. Carvalho de Moraes LO, Tedesco RC, Arraez-Aybar LA, Klein O, Mérida-Velasco JR, Alonso LG. PMID: 26708184; PMCID: PMC4698616.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    144. Craniofacial Stem Cells in Health and Disease. J Dent Res. 2015 Nov; 94(11):1485-6. Klein OD, Nör JE. PMID: 26494794.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    145. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. Goodwin AF, Kim R, Bush JO, Klein OD. PMID: 26589935; PMCID: PMC7398124.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    146. Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects. J Bone Miner Res. 2016 Jan; 31(1):152-62. Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD. PMID: 26179131; PMCID: PMC4840178.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    147. Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model. Sci Rep. 2015 Jun 30; 5:11658. Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L. PMID: 26123406; PMCID: PMC4485067.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    148. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan-Feb; 18(1):31-40. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. PMID: 26086993; PMCID: PMC4826035.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    149. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 03. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. PMID: 26050928; PMCID: PMC4471827.
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    150. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 01; 24(15):4340-52. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. PMID: 25954033; PMCID: PMC4492397.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    151. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167A(5):1026-32. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. PMID: 25885067.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    152. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. PMID: 25923139; PMCID: PMC4414615.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    153. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May 05; 11(5):673-80. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. PMID: 25921530; PMCID: PMC4426059.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    154. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 07; 11(1):33-42. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. PMID: 25818302; PMCID: PMC4394041.
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    155. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015 Mar 24; 4. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. PMID: 25803487; PMCID: PMC4370217.
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    156. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar 23; 7(1):23-6. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O. PMID: 25634121; PMCID: PMC4817538.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    157. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19. Barlow LA, Klein OD. PMID: 25662267; PMCID: PMC4435577.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    158. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 07; 512(7512):44-8. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. PMID: 25079326; PMCID: PMC4252015.
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    159. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. PMID: 24993944; PMCID: PMC4197660.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    160. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. PMID: 24924195; PMCID: PMC4067960.
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    161. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. PMID: 25333067; PMCID: PMC4190877.
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    162. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014 May 01; (87). Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. PMID: 24834972; PMCID: PMC4141628.
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    163. Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Jun; 93(6):589-95. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L. PMID: 24710391.
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    164. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct; 164A(10):2455-60. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. PMID: 24700731; PMCID: PMC4167166.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    165. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-62. Mendelsohn BA, Jeng LLB, Oberoi S, Klein OD. PMID: 24535103.
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    166. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun; 164A(6):1425-30. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. PMID: 24668879; PMCID: PMC4115793.
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    167. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul 15; 325(2):96-103. Naveau A, Seidel K, Klein OD. PMID: 24530577; PMCID: PMC4072742.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    168. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. PMID: 24506883; PMCID: PMC3951379.
      View in: PubMed   Mentions: 208     Fields:    Translation:AnimalsCells
    169. Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 01; 386(1):1-11. Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD. PMID: 24361260; PMCID: PMC3921686.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    170. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan; 102(1):1-13. Li CY, Prochazka J, Goodwin AF, Klein OD. PMID: 24343791; PMCID: PMC9202745.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    171. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb; 52(2):79-92. Kuang-Hsien Hu J, Mushegyan V, Klein OD. PMID: 24307456; PMCID: PMC4252016.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    172. Current trends in stem cell therapy for improvement of bone quality. Histol Histopathol. 2014 Jun; 29(6):691-7. Yamada Y, Nakamura S, Klein OD, Ito K. PMID: 24327103.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    173. American Journal of Medical Genetics Part A. The society of craniofacial genetics and developmental biology 35th annual meeting. 2013; 161(12):2938-2952. Klein OD, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT.
    174. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):318-32. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. PMID: 24124058; PMCID: PMC3844689.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    175. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 01; 23(3):682-92. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. PMID: 24057668; PMCID: PMC3888259.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    176. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1. Oishi PE, Klein OD, Keller RL, University of California San Francisco Neonatology and Pediatric Critical Care Early Faculty Develop. PMID: 23973233.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    177. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013; 198(2):99-110. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y. PMID: 24192998.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    178. Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey. Int J Oral Sci. 2013 Sep; 5(3):121-9. Jones KB, Klein OD. PMID: 23887128; PMCID: PMC3967329.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    179. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug; 140(16):3348-59. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. PMID: 23863486; PMCID: PMC3737717.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    180. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. PMID: 23728424; PMCID: PMC3735916.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    181. Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging. Am J Med Genet A. 2013 Jul; 161A(7):1585-93. Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD. PMID: 23687000; PMCID: PMC4414120.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    182. The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes. J Exp Zool B Mol Dev Evol. 2013 Jul; 320(5):307-20. Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. PMID: 23606267.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    183. If a stem cell dies in the crypt, and no one is around to see it…. Cell Stem Cell. 2013 Apr 04; 12(4):389-90. Nusse YM, Klein OD. PMID: 23561439.
      View in: PubMed   Mentions: 3     Fields:    
    184. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. PMID: 23462476; PMCID: PMC3596986.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    185. Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells. 2013 Mar; 31(3):572-80. Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T. PMID: 23225744; PMCID: PMC4043220.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    186. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. PMID: 23352663; PMCID: PMC3563842.
      View in: PubMed   Mentions: 115     Fields:    Translation:Animals
    187. Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep. 2013; 3:2277. Felfly H, Klein OD. PMID: 23880645; PMCID: PMC3721083.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    188. Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion. Dent 3000. 2013; 1(1). Modesto A, Klein O, Tenuta LM, Gerlach RF, Vieira AR. PMID: 25392764; PMCID: PMC4225817.
      View in: PubMed   Mentions:
    189. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS One. 2012; 7(11):e50090. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L. PMID: 23226240; PMCID: PMC3511455.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    190. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 01; 374(1):185-97. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. PMID: 23201021; PMCID: PMC4086262.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    191. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet. 2012 Dec; 44(12):1360-4. Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. PMID: 23160099; PMCID: PMC3736322.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    192. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun; 83(6):539-44. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA. PMID: 22946697; PMCID: PMC4115672.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    193. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan; 19(1):15-24. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. PMID: 22742471; PMCID: PMC3522131.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    194. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug 14; 23(2):317-28. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. PMID: 22819339; PMCID: PMC3690347.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    195. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul; 56(3):495-520. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. PMID: 22835534; PMCID: PMC3494412.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    196. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012; 7(5):e37670. Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M. PMID: 22629441; PMCID: PMC3358280.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    197. From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr; 2(2):165-82. Jheon AH, Seidel K, Biehs B, Klein OD. PMID: 24009032; PMCID: PMC3632217.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    198. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun 15; 366(2):357-66. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. PMID: 22537490; PMCID: PMC3690274.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    199. Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res. 2012 Apr; 91(4):387-93. Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD. PMID: 22328578; PMCID: PMC3310757.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    200. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 2012 Feb; 190(2):389-401. Collaborative Cross Consortium. PMID: 22345608; PMCID: PMC3276630.
      View in: PubMed   Mentions: 287     Fields:    Translation:Animals
    201. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011 Sep 18; 478(7368):255-9. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. PMID: 21927002; PMCID: PMC4251967.
      View in: PubMed   Mentions: 582     Fields:    Translation:HumansAnimalsCells
    202. Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011; 6(9):e24536. Jheon AH, Li CY, Wen T, Michon F, Klein OD. PMID: 21931743; PMCID: PMC3169592.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    203. Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development. 2011 Sep; 138(18):4063-73. Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD. PMID: 21862563; PMCID: PMC3160100.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    204. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011 Jun; 7(6):e1002098. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. PMID: 21655085; PMCID: PMC3107195.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    205. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. PMID: 21458441; PMCID: PMC3440302.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    206. Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor. J Exp Zool B Mol Dev Evol. 2011 Jul 15; 316(5):347-58. Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M. PMID: 21455944.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    207. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 01; 124(Pt 5):745-54. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. PMID: 21285247; PMCID: PMC3039019.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    208. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan; 155A(1):22-32. Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. PMID: 21204207.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    209. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. PMID: 20978072; PMCID: PMC3049274.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    210. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. PMID: 20978073; PMCID: PMC3049275.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    211. Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization. J Craniofac Surg. 2010 Sep; 21(5):1376-9. Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD. PMID: 20856024.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    212. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct; 137(19):3221-31. Ahn Y, Sanderson BW, Klein OD, Krumlauf R. PMID: 20724449; PMCID: PMC6512258.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    213. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15497-502. Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R. PMID: 20709958; PMCID: PMC2932592.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    214. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. PMID: 20170752; PMCID: PMC2849867.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    215. Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22364-8. Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L. PMID: 20018768; PMCID: PMC2799759.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    216. Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice. J Exp Zool B Mol Dev Evol. 2009 Jul 15; 312B(5):473-85. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. PMID: 19101957; PMCID: PMC2837846.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    217. Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):292-308. Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD. PMID: 19127536; PMCID: PMC2880865.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    218. Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr 15; 328(2):493-505. Catón J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA. PMID: 19233155; PMCID: PMC2880856.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    219. Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury. Acta Anaesthesiol Scand. 2009 Jan; 53(1):128-30. Baumann A, Audibert G, Klein O, Mertes PM. PMID: 18945248.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    220. Genomic variants of ATF3 in patients with hypospadias. J Urol. 2008 Nov; 180(5):2183-8; discussion 2188. Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin LS. PMID: 18804813.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    221. Mutations of CXorf6 are associated with a range of severities of hypospadias. Eur J Endocrinol. 2008 Oct; 159(4):453-8. Kalfa N, Liu B, Klein O, Ophir K, Audran F, Wang MH, Mei C, Sultan C, Baskin LS. PMID: 18635673.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    222. The branching programme of mouse lung development. Nature. 2008 Jun 05; 453(7196):745-50. Metzger RJ, Klein OD, Martin GR, Krasnow MA. PMID: 18463632; PMCID: PMC2892995.
      View in: PubMed   Mentions: 370     Fields:    Translation:Animals
    223. Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male. Hepatol Int. 2008 09; 2(3):390-4. Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S. PMID: 19669271; PMCID: PMC2716892.
      View in: PubMed   Mentions: 13     Fields:    
    224. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan; 135(2):377-85. Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR. PMID: 18077585; PMCID: PMC2555979.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    225. Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH. Clin Genet. 2007 Mar; 71(3):260-6. Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA. PMID: 17309649.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    226. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs. 2007; 186(1):60-9. D'Souza RN, Klein OD. PMID: 17627119.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    227. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug; 11(2):181-90. Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR. PMID: 16890158; PMCID: PMC2847684.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    228. Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization. Am J Med Genet A. 2005 Nov 01; 138(4):349-54. Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA. PMID: 16200635.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    229. Brachydactylic multiple delta phalanges plus syndrome. Am J Med Genet A. 2005 Sep 15; 138(1):41-4. Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD. PMID: 16092122.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    230. Case report: Y;6 translocation with deletion of 6p. Clin Dysmorphol. 2005 Apr; 14(2):93-96. Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A. PMID: 15770132.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    231. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet. 2004 Jun; 65(6):477-82. Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA. PMID: 15151506.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    232. The Ultrasound Review of Obstetrics and Gynecology. Congenital Müllerian anomalies: A review of currently available imaging modalities. 2002; 2(1):56-67. Raga F, Bonilla-Musoles F, Osborne NG, Casañ EM, Klein O, Bonilla F .
    233. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod. 1999 Nov; 14(11):2851-4. Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F. PMID: 10548635.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    234. The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells. J Virol. 1999 Apr; 73(4):3264-72. Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D. PMID: 10074180; PMCID: PMC104090.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    235. Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec 01; 33(4):601-12. Surti T, Klein O, Aschheim K, DiMaio D, Smith SO. PMID: 9849943.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    236. Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol. 1998 Nov; 72(11):8921-32. Klein O, Polack GW, Surti T, Kegler-Ebo D, Smith SO, DiMaio D. PMID: 9765437; PMCID: PMC110309.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    237. Virocrine transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol. 1998; 52:397-421. DiMaio D, Lai CC, Klein O. PMID: 9891803.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    238. Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli. Biochemistry. 1995 Jan 10; 34(1):378-84. Lee ME, Dyer DH, Klein OD, Bolduc JM, Stoddard BL, Koshland DE. PMID: 7819221.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
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