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Ophir Klein, PhD, MD

Title(s)Professor, Orofacial Sciences
SchoolSchool of Dentistry
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-502-2517
ORCID ORCID Icon0000-0002-6254-7082 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoGenetics residency2007School of Medicine
    Yale UniversityPediatrics residency2003School of Medicine
    Yale UniversityM.D.2000School of Medicine
    Yale UniversityPh.D.1999School of Medicine
    University of California, BerkeleyB.A.1993
    Collapse Awards and Honors
    2018Elected member, National Academy of Medicine
    2017Lawrence A. Tabak Lecturership, University of Rochester
    2017Craniofacial Biology Distinguished Scientist Award, International Association for Dental Research
    2016Inaugural Sustaining Outstanding Achievement in Research (SOAR) R35 Award, NIDCR
    2016Charles J. Epstein Professor of Human Genetics
    2015Faculty Research Lecturer Award, UCSF School of Dentistry
    2015E. Mead Johnson Award, Society for Pediatric Research
    2014Fellow, American Association for the Advancement of Science (AAAS)
    2014Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies
    2013Outstanding Faculty Mentorship Award, UCSF Graduate Students' Association
    2013Elected Member, American Society for Clinical Investigation
    2013Physician Scientist Award, California Institute of Regenerative Medicine
    2010New Innovator Award, National Institutes of Health
    2009Harold M. Frost Young Investigator Award, American Society for Bone and Mineral Research
    2009Elected Member, Western Society for Pediatric Research
    2009Basil O'Connor Award, March of Dimes
    2008Elected Member, Society for Pediatric Research
    2008New Faculty Award, California Institute of Regenerative Medicine
    2008Charles E. Culpeper Scholar, Goldman Philanthropic Partnerships
    2008Young Investigator, United States Bone and Joint Decade
    2005Young Investigator Research Grant Award, American Academy of Pediatrics Section on Genetics and Birt
    2005Fellow Research Award, Society for Pediatric Research
    2005David W. Smith Research Award, Western Society for Pediatric Research
    2004Fellow, Pediatric Scientist Development Program, NICHD
    2004Fellow, American Academy of Pediatrics
    1999Dean's Distinguished Thesis Commendation, Yale University Graduate School
    1993Medical Scientist Training Program, National Institutes of Health
    1989Chancellor's Scholarship, University of California, Berkeley

    Collapse Overview 
    Collapse Overview
    Ophir Klein is Professor of Orofacial Sciences and Pediatrics, the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, and the Charles J. Epstein Professor of Human Genetics at the University of California, San Francisco (UCSF). He serves as Chief of the Division of Medical Genetics, Chair of the Division of Craniofacial Anomalies, Medical Director of the Craniofacial Center, and Director of the Program in Craniofacial Biology.
    The Klein laboratory focuses on understanding how organs form in developing embryos and how they regenerate in adults. When developmental and regenerative processes go awry, then birth defects, cancer and other diseases can result. The group's research is centered on understanding how development and regeneration normally occur in the hope of one day treating diseases that result from abnormalities in these processes.
    A central focus in the lab is craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. The maintenance, repair and growth of many adult organs, such as the bone marrow, skin, brain, and gastrointestinal tract, depend on tissue-specific populations of stem cells. The lab uses the rodent incisor, which grows continuously throughout the life of the animal, as a model system to understand adult stem cells. We intend to use the insights provided by our experiments in mice to guide us in the use of stem cells in regenerating dental and craniofacial tissues as a paradigm for developing replacement organs.
    Another major area of study is regeneration of the gastrointestinal tract. The amazing ability of the mammalian gastrointestinal epithelium to renew has long fascinated biologists. Our research aims to address fundamental questions in this field, including the identity, regulation and plasticity of intestinal stem cells.
    Finally, the laboratory is interested in how positive and negative modulators of signaling affect development, homeostasis and cancer. We are studying the roles of these molecules in the patterning and outgrowth of teeth, taste papillae, the oral mucosa, and other tissues and organs.

    Collapse Research 
    Collapse Research Activities and Funding
    Enamel atlas: systems-level amelogenesis tools at multiple scales
    NIH/NIDCR UG3DE028872Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Cellular and molecular control of tooth morphogenesis
    NIH/NIDCR R01DE028496Jul 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Functional Molecular Investigation of Inflammatory Bowel Disease (IBD) Risk Variants
    NIH/NIDDK R01DK119979Sep 18, 2018 - May 31, 2022
    Role: Co-Principal Investigator
    Regulation of organogenesis through regional variations in tissue mechanics
    NIH/NIDCR R01DE027620Mar 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    2018 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar
    NIH/NIDCR R13DE027575Jan 1, 2018 - Dec 31, 2018
    Role: Principal Investigator
    Using human intestinal organoids to model IBD pathogenesis
    The Kenneth Rainin Foundation Innovator Award 2017-281Oct 1, 2017 - Sep 30, 2018
    Role: Principal Investigator
    Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH/NIDCR U24DE026914Mar 1, 2017 - Feb 28, 2020
    Role: Co-Principal Investigator
    The role of stem cell competition in precancerous field formation
    UCSF UCSF Resource Allocation ProgramJan 1, 2017 - Dec 31, 2017
    Role: Principal Investigator
    Harnessing natural stem cell-based strategies for mammalian dental renewal
    NIH/NIDCR R35DE026602Sep 22, 2016 - Jun 30, 2024
    Role: Principal Investigator
    2016 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar
    NIH/NIDCR R13DE025777Jan 19, 2016 - Jan 18, 2017
    Role: Principal Investigator
    Systems morphogenesis of tooth development
    The Royal Society IE150381Nov 1, 2015 - Oct 31, 2017
    Role: Principal Investigator
    University of California Tissue Regeneration Resource Center (UCTRRC)
    NIH/NIDCR R34DE025592Sep 8, 2015 - Aug 31, 2016
    Role: Co-Principal Investigator
    The role of Hippo and YAP/TAZ in dental renewal
    NIH R01DE024988Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironment
    NIH/NIDDK U01DK103147Sep 5, 2014 - Aug 31, 2024
    Role: Principal Investigator
    Developing 3D Craniofacial Morphometry Data and Tools to Transform Dysmorphology
    NIH/NIDCR U01DE024440May 16, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    Stem cell therapy for inflammatory bowel disease
    California Institute of Rgenerative Medicine RN3-06525Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    The role of Sprouty genes in development of mammalian external genitalia
    NIH/NIDDK R01DK095002Sep 18, 2012 - Aug 31, 2014
    Role: Principal Investigator
    The role of Bmi1 in regulation of dental stem cells
    NIH/NIDCR R01DE021420Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    An evolutionary-developmental approach to stem cells using teeth as a model
    NIH DP2OD007191Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    The role of Sprouty genes in development of the circumvallate papilla
    NIH/NIDCD R21DC011108Jul 6, 2010 - Jun 30, 2012
    Role: Principal Investigator
    The role of Spry2 in regulation of bone formation
    NIH/NIAMS R03AR057121Apr 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    The Role of microRNAs in Tooth Regeneration using the Mouse Incisor Model
    NIH/NIDCR R21DE019958Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Analysis of the Role of Sprouty Genes in Tooth Development
    NIH/NIDCR K08DE017654Jul 1, 2007 - Jun 30, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions. J Dent Res. 2020 Jul 17; 22034520939013. Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA. PMID: 32674684.
      View in: PubMed   Mentions:    Fields:    
    2. FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 Jul 14; 18(1):87. Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X. PMID: 32664967.
      View in: PubMed   Mentions:    Fields:    
    3. YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate. J Dent Res. 2020 Jul 06; 22034520935372. Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD. PMID: 32623954.
      View in: PubMed   Mentions:    Fields:    
    4. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. BMC Cancer. 2020 Jun 10; 20(1):542. Hagerling C, Owyong M, Sitarama V, Wang CY, Lin C, van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V. PMID: 32522170.
      View in: PubMed   Mentions:    Fields:    
    5. Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images. Sensors (Basel). 2020 Jun 03; 20(11). Bannister JJ, Crites SR, Aponte JD, Katz DC, Wilms M, Klein OD, Bernier FPJ, Spritz RA, Hallgrímsson B, Forkert ND. PMID: 32503190.
      View in: PubMed   Mentions:    Fields:    
    6. Automated syndrome diagnosis by three-dimensional facial imaging. Genet Med. 2020 Jun 01. Hallgrímsson B, Aponte JD, Katz DC, Bannister JJ, Riccardi SL, Mahasuwan N, McInnes BL, Ferrara TM, Lipman DM, Neves AB, Spitzmacher JAJ, Larson JR, Bellus GA, Pham AM, Aboujaoude E, Benke TA, Chatfield KC, Davis SM, Elias ER, Enzenauer RW, French BM, Pickler LL, Shieh JTC, Slavotinek A, Harrop AR, Innes AM, McCandless SE, McCourt EA, Meeks NJL, Tartaglia NR, Tsai AC, Wyse JPH, Bernstein JA, Sanchez-Lara PA, Forkert ND, Bernier FP, Spritz RA, Klein OD. PMID: 32475986.
      View in: PubMed   Mentions: 1     Fields:    
    7. Tools and Concepts for Interrogating and Defining Cellular Identity. Cell Stem Cell. 2020 May 07; 26(5):632-656. McKinley KL, Castillo-Azofeifa D, Klein OD. PMID: 32386555.
      View in: PubMed   Mentions:    Fields:    
    8. The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community. G3 (Bethesda). 2020 May 04; 10(5):1503-1510. Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ. PMID: 32152007.
      View in: PubMed   Mentions:    Fields:    
    9. Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020 Apr 22; 11(1):1936. Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel M, Itzkovitz S. PMID: 32321913.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Safety and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 replacement protein, in human subjects. Br J Clin Pharmacol. 2020 Apr 06. Körber I, Klein OD, Morhart P, Faschingbauer F, Grange DK, Clarke A, Bodemer C, Maitz S, Huttner K, Kirby N, Durand C, Schneider H. PMID: 32250462.
      View in: PubMed   Mentions:    Fields:    
    11. From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells. Curr Opin Cell Biol. 2020 Apr; 63:88-101. Trentesaux C, Striedinger K, Pomerantz JH, Klein OD. PMID: 32036295.
      View in: PubMed   Mentions:    Fields:    
    12. Molecular and cellular mechanisms of tooth development, homeostasis and repair. Development. 2020 01 24; 147(2). Yu T, Klein OD. PMID: 31980484.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Generation of Knockout Gene-Edited Human Intestinal Organoids. Methods Mol Biol. 2020; 2171:215-230. Rajendra C, Wald T, Barber K, Spence JR, Fattahi F, Klein OD. PMID: 32705644.
      View in: PubMed   Mentions:    Fields:    
    14. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell. 2019 12 05; 25(6):814-829.e6. Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. PMID: 31809739.
      View in: PubMed   Mentions:    Fields:    
    15. Use of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G845-G852. Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MK. PMID: 31589468.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 09; 21(9):1102-1112. Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. PMID: 31481792.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar. JBMR Plus. 2019 Aug; 3(8):e10205. Marangoni P, Charles C, Ahn Y, Seidel K, Jheon A, Ganss B, Krumlauf R, Viriot L, Klein OD. PMID: 31485553.
      View in: PubMed   Mentions:
    18. Case Report of Floating-Harbor Syndrome With Bilateral Cleft Lip. Cleft Palate Craniofac J. 2020 01; 57(1):132-136. Ko J, Pomerantz JH, Perry H, Shieh JT, Slavotinek AM, Oberoi S, Klein OD. PMID: 31248274.
      View in: PubMed   Mentions:    Fields:    
    19. Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development. Int J Mol Sci. 2019 May 08; 20(9). El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. PMID: 31072004.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting. Am J Med Genet A. 2019 05; 179(5):864-869. Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. PMID: 30793834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration. EMBO J. 2019 02 15; 38(4). Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. PMID: 30635334.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium. Am J Physiol Gastrointest Liver Physiol. 2019 02 01; 316(2):G247-G250. Wang TC, Martin MG, Kuo CJ, Klein OD, Niland J. PMID: 30548077.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila. Am J Physiol Gastrointest Liver Physiol. 2019 03 01; 316(3):G313-G322. Zwick RK, Ohlstein B, Klein OD. PMID: 30543448.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    24. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 2019 01 15; 38(2). Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B. PMID: 30523147.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells. Cell Stem Cell. 2019 01 03; 24(1):183-192.e8. Jones KB, Furukawa S, Marangoni P, Ma H, Pinkard H, D'Urso R, Zilionis R, Klein AM, Klein OD. PMID: 30472156.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    26. Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development. Front Genet. 2018; 9:542. Prochazkova M, Prochazka J, Marangoni P, Klein OD. PMID: 30505318.
      View in: PubMed   Mentions:
    27. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 11 05; 145(21). May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. PMID: 30305288.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function. Bioessays. 2018 12; 40(12):e1800140. Calamari ZT, Hu JK, Klein OD. PMID: 30387177.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature. 2018 11; 563(7732):514-521. Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT. PMID: 30356216.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. PMID: 30305617.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    31. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 10; 562(7727):E22. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. PMID: 30013120.
      View in: PubMed   Mentions:    Fields:    
    32. The intestinal epithelial response to damage. Sci China Life Sci. 2018 Oct; 61(10):1205-1211. Weichselbaum L, Klein OD. PMID: 30194677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    33. Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2160-2173. Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, Pogontke C, Carmona RM, Salvador JM, Perez-Pomares JM, Klein OD, Prósper F, Jimenez-Borreguero LJ, Bernad A. PMID: 29930004.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    34. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018; 3:21. Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D. PMID: 30131872.
      View in: PubMed   Mentions:
    35. SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 07 17; 145(14). Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. PMID: 29945863.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 07 17; 9(1):2854. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. PMID: 30018293.
      View in: PubMed   Mentions:    Fields:    
    37. Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. 2018 Jul 05; 23(1):147. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. PMID: 29979989.
      View in: PubMed   Mentions: 1     Fields:    
    38. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 07; 559(7712):109-113. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. PMID: 29950724.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. PMID: 29897330.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    40. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 06 13; 9(1):2333. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. PMID: 29899403.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    41. Label reading, numeracy and food & nutrition involvement. Appetite. 2018 09 01; 128:214-222. Mulders MDGH, Corneille O, Klein O. PMID: 29886052.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care. J Dent Res. 2018 04; 97(4):361-363. Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH. PMID: 29557734.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. PMID: 29386123.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing. Stem Cells. 2018 04; 36(4):562-573. Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F. PMID: 29282831.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor. Development. 2018 01 08; 145(1). Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F. PMID: 29180573.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. Hum Mol Genet. 2018 01 01; 27(1):107-119. Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. PMID: 29126155.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    47. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 01 22; 44(2):165-178.e6. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. PMID: 29290586.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    48. Body size and allometric variation in facial shape in children. Am J Phys Anthropol. 2018 02; 165(2):327-342. Larson JR, Manyama MF, Cole JB, Gonzalez PN, Percival CJ, Liberton DK, Ferrara TM, Riccardi SL, Kimwaga EA, Mathayo J, Spitzmacher JA, Rolian C, Jamniczky HA, Weinberg SM, Roseman CC, Klein O, Lukowiak K, Spritz RA, Hallgrimsson B. PMID: 29178597.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Meeting report: a hard look at the state of enamel research. Int J Oral Sci. 2017 11 22; 9(11):e3. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. PMID: 29165423.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    50. Feedback regulation of RTK signaling in development. Dev Biol. 2019 03 01; 447(1):71-89. Neben CL, Lo M, Jura N, Klein OD. PMID: 29079424.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    51. Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents. Am J Gastroenterol. 2018 02; 113(2):265-272. Ghione S, Sarter H, Fumery M, Armengol-Debeir L, Savoye G, Ley D, Spyckerelle C, Pariente B, Peyrin-Biroulet L, Turck D, Gower-Rousseau C, Andre JM, Antonietti M, Aouakli A, Armand A, Aroichane I, Assi F, Aubet JP, Auxenfants E, Ayafi-Ramelot F, Bankovski D, Barbry B, Bardoux N, Baron P, Baudet A, Bazin B, Bebahani A, Becqwort JP, Benet V, Benali H, Benguigui C, Soussan BE, Bental A, Berkelmans I, Bernet J, Bernou K, Bernou-Dron C, Bertot P, Bertiaux-Vandaële N, Bertrand V, Billoud E, Biron N, Bismuth B, Bleuet M, Blondel F, Blondin V, Bohon P, Boniface E, Bonnière P, Bonvarlet E, Bonvarlet P, Boruchowicz A, Bostvironnois R, Boualit M, Bouche B, Boudaillez C, Bourgeaux C, Bourgeois M, Bourguet A, Bourienne A, Branche J, Bray G, Brazier F, Breban P, Brihier H, Brung-Lefebvre V, Bulois P, Burgiere P, Butel J, Canva JY, Canva-Delcambre V, Capron JP, Cardot F, Carpentier P, Cartier E, Cassar JF, Cassagnou M, Castex JF, Catala P, Cattan S, Catteau S, Caujolle B, Cayron G, Chandelier C, Chantre M, Charles J, Charneau T, Chavance-Thelu M, Chirita D, Choteau A, Claerbout JF, Clergue PY, Coevoet H, Cohen G, Collet R, Colombel JF, Coopman S, Corvisart J, Cortot A, Couttenier F, Crinquette JF, Crombe V, Dadamessi I, Dapvril V, Davion T, Dautreme S, Debas J, Degrave N, Dehont F, Delatre C, Delcenserie R, Delette O, Delgrange T, Delhoustal L, Delmotte JS, Demmane S, Deregnaucourt G, Descombes P, Desechalliers JP, Desmet P, Desreumaux P, Desseaux G, Desurmont P, Devienne A, Devouge E, Devred M, Devroux A, Dewailly A, Dharancy S, Di Fiore A, Djeddi D, Djedir R, Dreher-Duwat ML, Dubois R, Dubuque C, Ducatillon P, Duclay J, Ducrocq B, Ducrot F, Ducrotte P, Dufilho A, Duhamel C, Dujardin D, Dumant-Forest C, Dupas JL, Dupont F, Duranton Y, Duriez A, El Achkar K, El Farisi M, Elie C, Elie-Legrand MC, Elkhaki A, Eoche M, Evrard D, Evrard JP, Fatome A, Filoche B, Finet L, Flahaut M, Flamme C, Foissey D, Fournier P, Foutrein-Comes MC, Foutrein P, Fremond D, Frere T, Fumery M, Gallet P, Gamblin C, Ganga-Zandzou PS, Gérard R, Geslin G, Gheyssens Y, Ghossini N, Ghrib S, Gilbert T, Gillet B, Godard D, Godard P, Godchaux JM, Godchaux R, Goegebeur G, Goria O, Gottrand F, Gower P, Grandmaison B, Groux M, Guedon C, Guillard JF, Guillem L, Guillemot F, Guimber D, Haddouche B, Hakim S, Hanon D, Hautefeuille V, Heckestweiller P, Hecquet G, Hedde JP, Hellal H, Henneresse PE, Heyman B, Heraud M, Herve S, Hochain P, Houssin-Bailly L, Houcke P, Huguenin B, Iobagiu S, Ivanovic A, Iwanicki-Caron I, Janicki E, Jarry M, Jeu J, Joly JP, Jonas C, Katherin F, Kerleveo A, Khachfe A, Kiriakos A, Kiriakos J, Klein O, Kohut M, Kornhauser R, Koutsomanis D, Laberenne JE, Laffineur G, Lagarde M, Lannoy P, Lapchin J, Lapprand M, Laude D, Leblanc R, Lecieux P, Leclerc N, Le Couteulx C, Ledent J, Lefebvre J, Lefiliatre P, Legrand C, Le Grix A, Lelong P, Leluyer B, Lenaerts C, Lepileur L, Leplat A, Lepoutre-Dujardin E, Leroi H, Leroy MY, Lesage JP, Lesage X, Lesage J, Lescanne-Darchis I, Lescut J, Lescut D, Leurent B, Levy P, Lhermie M, Lion A, Lisambert B, Loire F, Louf S, Louvet A, Luciani M, Lucidarme D, Lugand J, Macaigne O, Maetz D, Maillard D, Mancheron H, Manolache O, Marks-Brunel AB, Marti R, Martin F, Martin G, Marzloff E, Mathurin P, Mauillon J, Maunoury V, Maupas JL, Mesnard B, Metayer P, Methari L, Meurisse B, Meurisse F, Michaud L, Mirmaran X, Modaine P, Monthe A, Morel L, Mortier PE, Moulin E, Mouterde O, Mudry J, Nachury M, Khac NE, Notteghem B, Ollevier V, Ostyn A, Ouraghi A, Ouvry D, Paillot B, Panien-Claudot N, Paoletti C, Papazian A, Parent B, Pariente B, Paris JC, Patrier P, Paupart L, Pauwels B, Pauwels M, Petit R, Piat M, Piotte S, Plane C, Plouvier B, Pollet E, Pommelet P, Pop D, Pordes C, Pouchain G, Prades P, Prevost A, Prevost JC, Quesnel B, Queuniet AM, Quinton JF, Rabache A, Rabelle P, Raclot G, Ratajczyk S, Rault D, Razemon V, Reix N, Revillon M, Richez C, Robinson P, Rodriguez J, Roger J, Roux JM, Rudelli A, Saber A, Savoye G, Schlosseberg P, et al. PMID: 28809388.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    52. Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov; 32(11):2219-2231. Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD. PMID: 28650075.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    53. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 09 08; 292(36):15062-15069. Du W, Hu JK, Du W, Klein OD. PMID: 28733464.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    54. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017 Oct; 96(11):1306-1313. Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC. PMID: 28732181.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    55. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul; 13(7):e1006914. El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. PMID: 28715412.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. Automatic recognition of the XLHED phenotype from facial images. Am J Med Genet A. 2017 Sep; 173(9):2408-2414. Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK. PMID: 28691769.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor. J Dent Res. 2017 Nov; 96(12):1438-1444. Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD. PMID: 28644741.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    58. A review of craniofacial and dental findings of the RASopathies. Orthod Craniofac Res. 2017 Jun; 20 Suppl 1:32-38. Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S. PMID: 28643916.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    59. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017 06 15; 144(12):2212-2221. Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD. PMID: 28506989.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    60. Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis. Elife. 2017 05 05; 6. Seidel K, Marangoni P, Tang C, Houshmand B, Du W, Maas RL, Murray S, Oldham MC, Klein OD. PMID: 28475038.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    61. The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. G3 (Bethesda). 2017 05 05; 7(5):1439-1450. Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B. PMID: 28280213.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    62. An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell. 2017 07 06; 21(1):91-106.e6. Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD. PMID: 28457749.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    63. From snapshots to movies: Understanding early tooth development in four dimensions. Dev Dyn. 2017 06; 246(6):442-450. Kim R, Green JBA, Klein OD. PMID: 28324646.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    64. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. PMID: 28238796.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    65. What Do You Believe In? French Translation of the FAD-Plus to Assess Beliefs in Free Will and Determinism and Their Relationship with Religious Practices and Personality Traits. Psychol Belg. 2017 Feb 20; 57(1):1-16. Caspar EA, Verdin O, Rigoni D, Cleeremans A, Klein O. PMID: 30479450.
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    66. Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1641-E1650. Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R. PMID: 28196895.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    67. Human Facial Shape and Size Heritability and Genetic Correlations. Genetics. 2017 02; 205(2):967-978. Cole JB, Manyama M, Larson JR, Liberton DK, Ferrara TM, Riccardi SL, Li M, Mio W, Klein OD, Santorico SA, Hallgrímsson B, Spritz RA. PMID: 27974501.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    68. In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development. 2017 03 15; 144(6):1045-1055. Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD, Spence JR. PMID: 27927684.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    69. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 11 15; 143(22):4115-4126. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. PMID: 27660324.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    70. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 09 12; 214(6):645-7. Sharir A, Klein OD. PMID: 27621361.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    71. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5731-40. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. PMID: 27621461.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    72. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet. 2016 08; 12(8):e1006174. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. PMID: 27560698.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    73. Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. PLoS Genet. 2016 Aug; 12(8):e1006149. Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, Klein O, Mio W, Feingold E, Hallgrimsson B, Spritz RA, Marazita ML, Weinberg SM. PMID: 27560520.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    74. aE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 07 13; 7:12133. Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD. PMID: 27405641.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    75. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 Jul 07; 1(10). Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. PMID: 27525310.
      View in: PubMed   Mentions: 5     Fields:    
    76. JCI insight. Dual epithelial and immune cell function of Dvl1 regulates gut mircobiota composition and intestinal homeostasis. 2016; 1(10):e85395. View Publication.
    77. Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet. 2016 Oct 01; 25(R2):R86-R93. Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein OD. PMID: 27346519.
      View in: PubMed   Mentions: 1     Fields:    
    78. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 07 15; 143(14):2677-88. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y. PMID: 27287806.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    79. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 07; 88:170-179. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. PMID: 27130872.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    80. Prenatal ß-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016 10; 21(10):1417-33. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. PMID: 26830142.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    81. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. PMID: 26740656.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    82. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016 03; 20(2):81-7. Du W, Prochazka J, Prochazkova M, Klein OD. PMID: 26748348.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    83. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. PMID: 26702830.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    84. Development of synovial membrane in the temporomandibular joint of the human fetus. Eur J Histochem. 2015 Nov 26; 59(4):2569. Carvalho de Moraes LO, Tedesco RC, Arraez-Aybar LA, Klein O, Mérida-Velasco JR, Alonso LG. PMID: 26708184.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    85. Craniofacial Stem Cells in Health and Disease. J Dent Res. 2015 Nov; 94(11):1485-6. Klein OD, Nör JE. PMID: 26494794.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    86. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92. Goodwin AF, Kim R, Bush JO, Klein OD. PMID: 26589935.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    87. Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects. J Bone Miner Res. 2016 Jan; 31(1):152-62. Jheon AH, Prochazkova M, Meng B, Wen T, Lim YJ, Naveau A, Espinoza R, Cox TC, Sone ED, Ganss B, Siebel CW, Klein OD. PMID: 26179131.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    88. Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model. Sci Rep. 2015 Jun 30; 5:11658. Marangoni P, Charles C, Tafforeau P, Laugel-Haushalter V, Joo A, Bloch-Zupan A, Klein OD, Viriot L. PMID: 26123406.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    89. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan-Feb; 18(1):31-40. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. PMID: 26086993.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    90. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 03. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. PMID: 26050928.
      View in: PubMed   Mentions: 49     Fields:    
    91. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 01; 24(15):4340-52. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. PMID: 25954033.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    92. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167A(5):1026-32. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. PMID: 25885067.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    93. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. PMID: 25923139.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    94. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May 05; 11(5):673-80. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. PMID: 25921530.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    95. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 07; 11(1):33-42. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. PMID: 25818302.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    96. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015 Mar 24; 4. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. PMID: 25803487.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    97. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar 23; 7(1):23-6. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O. PMID: 25634121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    98. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19. Barlow LA, Klein OD. PMID: 25662267.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    99. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 07; 512(7512):44-8. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. PMID: 25079326.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    100. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. PMID: 24993944.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    101. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. PMID: 24924195.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    102. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. PMID: 25333067.
      View in: PubMed   Mentions: 4     Fields:    
    103. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014 May 01; (87). Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. PMID: 24834972.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    104. Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Jun; 93(6):589-95. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L. PMID: 24710391.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    105. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct; 164A(10):2455-60. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. PMID: 24700731.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    106. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-2. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. PMID: 24535103.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    107. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun; 164A(6):1425-30. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. PMID: 24668879.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    108. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul 15; 325(2):96-103. Naveau A, Seidel K, Klein OD. PMID: 24530577.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    109. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. PMID: 24506883.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    110. Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 01; 386(1):1-11. Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD. PMID: 24361260.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    111. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan; 102(1):1-13. Li CY, Prochazka J, Goodwin AF, Klein OD. PMID: 24343791.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    112. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb; 52(2):79-92. Kuang-Hsien Hu J, Mushegyan V, Klein OD. PMID: 24307456.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    113. Current trends in stem cell therapy for improvement of bone quality. Histol Histopathol. 2014 Jun; 29(6):691-7. Yamada Y, Nakamura S, Klein OD, Ito K. PMID: 24327103.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    114. American Journal of Medical Genetics Part A. The society of craniofacial genetics and developmental biology 35th annual meeting. 2013; 161(12):2938-2952. Klein OD, Bush JO, Knox SM, Jheon AH, Cordero DR, Richtsmeier JT.
    115. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):318-32. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. PMID: 24124058.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    116. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 01; 23(3):682-92. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. PMID: 24057668.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    117. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1. Oishi PE, Klein OD, Keller RL. PMID: 23973233.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    118. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013; 198(2):99-110. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y. PMID: 24192998.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    119. Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey. Int J Oral Sci. 2013 Sep; 5(3):121-9. Jones KB, Klein OD. PMID: 23887128.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    120. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013 Aug; 140(16):3348-59. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. PMID: 23863486.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    121. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. PMID: 23728424.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    122. Characterization of X-linked hypohidrotic ectodermal dysplasia (XL-HED) hair and sweat gland phenotypes using phototrichogram analysis and live confocal imaging. Am J Med Genet A. 2013 Jul; 161A(7):1585-93. Jones KB, Goodwin AF, Landan M, Seidel K, Tran DK, Hogue J, Chavez M, Fete M, Yu W, Hussein T, Johnson R, Huttner K, Jheon AH, Klein OD. PMID: 23687000.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    123. The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes. J Exp Zool B Mol Dev Evol. 2013 Jul; 320(5):307-20. Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. PMID: 23606267.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    124. If a stem cell dies in the crypt, and no one is around to see it…. Cell Stem Cell. 2013 Apr 04; 12(4):389-90. Nusse YM, Klein OD. PMID: 23561439.
      View in: PubMed   Mentions: 1     Fields:    
    125. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. PMID: 23462476.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    126. Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells. 2013 Mar; 31(3):572-80. Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, Abe A, Baba S, Furuichi Y, Izumi Y, Klein OD, Wakabayashi T. PMID: 23225744.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    127. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. PMID: 23352663.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    128. Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep. 2013; 3:2277. Felfly H, Klein OD. PMID: 23880645.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    129. Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion. Dent 3000. 2013; 1(1). Modesto A, Klein O, Tenuta LM, Gerlach RF, Vieira AR. PMID: 25392764.
      View in: PubMed   Mentions:
    130. microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells. PLoS One. 2012; 7(11):e50090. Wan M, Gao B, Sun F, Tang Y, Ye L, Fan Y, Klein OD, Zhou X, Zheng L. PMID: 23226240.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    131. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 01; 374(1):185-97. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. PMID: 23201021.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    132. A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet. 2012 Dec; 44(12):1360-4. Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. PMID: 23160099.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    133. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun; 83(6):539-44. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA. PMID: 22946697.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    134. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan; 19(1):15-24. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. PMID: 22742471.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    135. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug 14; 23(2):317-28. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. PMID: 22819339.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    136. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul; 56(3):495-520. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. PMID: 22835534.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    137. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012; 7(5):e37670. Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M. PMID: 22629441.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    138. From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr; 2(2):165-82. Jheon AH, Seidel K, Biehs B, Klein OD. PMID: 24009032.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    139. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun 15; 366(2):357-66. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. PMID: 22537490.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    140. Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res. 2012 Apr; 91(4):387-93. Purcell P, Jheon A, Vivero MP, Rahimi H, Joo A, Klein OD. PMID: 22328578.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    141. The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics. 2012 Feb; 190(2):389-401. PMID: 22345608.
      View in: PubMed   Mentions: 180     Fields:    Translation:Animals
    142. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011 Sep 18; 478(7368):255-9. Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ. PMID: 21927002.
      View in: PubMed   Mentions: 365     Fields:    Translation:HumansAnimalsCells
    143. Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One. 2011; 6(9):e24536. Jheon AH, Li CY, Wen T, Michon F, Klein OD. PMID: 21931743.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    144. Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development. 2011 Sep; 138(18):4063-73. Charles C, Hovorakova M, Ahn Y, Lyons DB, Marangoni P, Churava S, Biehs B, Jheon A, Lesot H, Balooch G, Krumlauf R, Viriot L, Peterkova R, Klein OD. PMID: 21862563.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    145. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011 Jun; 7(6):e1002098. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. PMID: 21655085.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    146. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. PMID: 21458441.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    147. Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor. J Exp Zool B Mol Dev Evol. 2011 Jul 15; 316(5):347-58. Hovorakova M, Prochazka J, Lesot H, Smrckova L, Churava S, Boran T, Kozmik Z, Klein O, Peterkova R, Peterka M. PMID: 21455944.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    148. PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 01; 124(Pt 5):745-54. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. PMID: 21285247.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    149. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A. 2011 Jan; 155A(1):22-32. Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. PMID: 21204207.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    150. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. PMID: 20978072.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    151. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov; 137(22):3753-61. Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD. PMID: 20978073.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    152. Clefting in trisomy 9p patients: genotype-phenotype correlation using microarray comparative genomic hybridization. J Craniofac Surg. 2010 Sep; 21(5):1376-9. Jelin A, Perry H, Hogue J, Oberoi S, Cotter PD, Klein OD. PMID: 20856024.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    153. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development. 2010 Oct; 137(19):3221-31. Ahn Y, Sanderson BW, Klein OD, Krumlauf R. PMID: 20724449.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    154. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15497-502. Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R. PMID: 20709958.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    155. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. PMID: 20170752.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    156. Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22364-8. Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L. PMID: 20018768.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    157. Temporal analysis of ectopic enamel production in incisors from sprouty mutant mice. J Exp Zool B Mol Dev Evol. 2009 Jul 15; 312B(5):473-85. Boran T, Peterkova R, Lesot H, Lyons DB, Peterka M, Klein OD. PMID: 19101957.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    158. Revitalization of a diastemal tooth primordium in Spry2 null mice results from increased proliferation and decreased apoptosis. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):292-308. Peterkova R, Churava S, Lesot H, Rothova M, Prochazka J, Peterka M, Klein OD. PMID: 19127536.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    159. Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr 15; 328(2):493-505. Catón J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA. PMID: 19233155.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    160. Continuous intravenous lidocaine in the treatment of paralytic ileus due to severe spinal cord injury. Acta Anaesthesiol Scand. 2009 Jan; 53(1):128-30. Baumann A, Audibert G, Klein O, Mertes PM. PMID: 18945248.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    161. Genomic variants of ATF3 in patients with hypospadias. J Urol. 2008 Nov; 180(5):2183-8; discussion 2188. Kalfa N, Liu B, Klein O, Wang MH, Cao M, Baskin LS. PMID: 18804813.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    162. Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Eur J Clin Invest. 2008 Aug; 38(8):548-54. Talmor Y, Bernheim J, Klein O, Green J, Rashid G. PMID: 18717824.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    163. Mutations of CXorf6 are associated with a range of severities of hypospadias. Eur J Endocrinol. 2008 Oct; 159(4):453-8. Kalfa N, Liu B, Klein O, Ophir K, Audran F, Wang MH, Mei C, Sultan C, Baskin LS. PMID: 18635673.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    164. The branching programme of mouse lung development. Nature. 2008 Jun 05; 453(7196):745-50. Metzger RJ, Klein OD, Martin GR, Krasnow MA. PMID: 18463632.
      View in: PubMed   Mentions: 251     Fields:    Translation:Animals
    165. Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male. Hepatol Int. 2008 09; 2(3):390-4. Klein OD, Kostiner DR, Weisiger K, Moffatt E, Lindeman N, Goodman S, Tuchman M, Packman S. PMID: 19669271.
      View in: PubMed   Mentions: 9     Fields:    
    166. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan; 135(2):377-85. Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR. PMID: 18077585.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    167. Interstitial deletions of chromosome 6q: genotype-phenotype correlation utilizing array CGH. Clin Genet. 2007 Mar; 71(3):260-6. Klein OD, Cotter PD, Moore MW, Zanko A, Gilats M, Epstein CJ, Conte F, Rauen KA. PMID: 17309649.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    168. Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. Cells Tissues Organs. 2007; 186(1):60-9. D'Souza RN, Klein OD. PMID: 17627119.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    169. Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug; 11(2):181-90. Klein OD, Minowada G, Peterkova R, Kangas A, Yu BD, Lesot H, Peterka M, Jernvall J, Martin GR. PMID: 16890158.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    170. Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization. Am J Med Genet A. 2005 Nov 01; 138(4):349-54. Klein OD, Cotter PD, Schmidt AM, Bick DP, Tidyman WE, Albertson DG, Pinkel D, Rauen KA. PMID: 16200635.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    171. Brachydactylic multiple delta phalanges plus syndrome. Am J Med Genet A. 2005 Sep 15; 138(1):41-4. Ahn CP, Lachman RS, Cox VA, Blumberg B, Klein OD. PMID: 16092122.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    172. Case report: Y;6 translocation with deletion of 6p. Clin Dysmorphol. 2005 Apr; 14(2):93-6. Klein OD, Backstrand K, Cotter PD, Marco E, Sherr E, Slavotinek A. PMID: 15770132.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    173. Irinotecan plus folinic acid/continuous 5-fluorouracil as simplified bimonthly FOLFIRI regimen for first-line therapy of metastatic colorectal cancer. BMC Cancer. 2004 Jul 20; 4:38. Teufel A, Steinmann S, Siebler J, Zanke C, Hohl H, Adami B, Schroeder M, Klein O, Höhler T, Galle PR, Heike M, Moehler M. PMID: 15265233.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    174. Prader-Willi syndrome resulting from an unbalanced translocation: characterization by array comparative genomic hybridization. Clin Genet. 2004 Jun; 65(6):477-82. Klein OD, Cotter PD, Albertson DG, Pinkel D, Tidyman WE, Moore MW, Rauen KA. PMID: 15151506.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    175. The Ultrasound Review of Obstetrics and Gynecology. Congenital Müllerian anomalies: A review of currently available imaging modalities. 2002; 2(1):56-67. Raga F, Bonilla-Musoles F, Osborne NG, Casañ EM, Klein O, Bonilla F .
    176. Rothia dentocariosa endocarditis complicated by multiple intracranial hemorrhages. South Med J. 2001 Apr; 94(4):438-40. Ricaurte JC, Klein O, LaBombardi V, Martinez V, Serpe A, Joy M. PMID: 11332915.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    177. Intraperitoneal infusion of glucose-based dialysate in the rat--an animal model for the study of peritoneal advanced glycation end-products formation and effect on peritoneal transport. Perit Dial Int. 2000 Nov-Dec; 20(6):656-61. Zeltzer E, Klein O, Rashid G, Katz D, Korzets Z, Bernheim J. PMID: 11216555.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    178. Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod. 1999 Nov; 14(11):2851-4. Raga F, Bonilla-Musoles F, Casañ EM, Klein O, Bonilla F. PMID: 10548635.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    179. An approach for high sensitivity detection of prostate cancer by analysis of changes in structuredness of the cytoplasmic matrix of lymphocytes specifically induced by PSA-ACT. J Urol. 1999 Jun; 161(6):1994-6. Klein O, Lin S, Embon O, Sazbon A, Zidan J, Kook AI. PMID: 10332488.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    180. The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells. J Virol. 1999 Apr; 73(4):3264-72. Klein O, Kegler-Ebo D, Su J, Smith S, DiMaio D. PMID: 10074180.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    181. Structural models of the bovine papillomavirus E5 protein. Proteins. 1998 Dec 01; 33(4):601-12. Surti T, Klein O, Aschheim K, DiMaio D, Smith SO. PMID: 9849943.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
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