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Richard Locksley, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-1559
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    Other Positions
    TitleHoward Hughes Investigator


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency

    Collapse Research 
    Collapse Research Activities and Funding
    Epithelial chitinase and lung homeostasis
    NIH/NHLBI R01HL128903Jul 1, 2015 - Apr 30, 2019
    Role: Principal Investigator
    INNATE AND ADAPTIVE IMMUNE RESPONSES IN TH2-HIGH ASTHMA
    NIH/NHLBI P01HL107202Aug 15, 2012 - May 31, 2017
    Role: Co-Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH/NIAID P01AI078869Jul 15, 2008 - Jun 30, 2013
    Role: Co-Investigator
    Understanding Asthma Endotypes
    NIH/NIAID U19AI077439Apr 1, 2008 - Mar 31, 2023
    Role: Co-Investigator
    Biology of Infectious Diseases Training Program
    NIH/NIAID T32AI007641Aug 1, 2000 - Aug 31, 2022
    Role: Co-Principal Investigator
    Interactions of Lymphocytes, Cytokines and Airway Cells
    NIH/NHLBI P50HL056385Sep 30, 1996 - Aug 31, 2006
    Role: Co-Principal Investigator
    Initiation of allergic immunity by parasites
    NIH/NIAID R01AI030663Jan 1, 1991 - May 31, 2017
    Role: Principal Investigator
    PSYCHOLOGICAL WELL-BEING OF LABORATORY-PAIRED PRIMATES
    NIH R01RR005355Sep 15, 1989 - Jun 30, 1993
    Role: Co-Investigator
    HELPER T CELL SUBSETS IN LEISHMANIASIS
    NIH/NIAID R01AI026918Jul 1, 1988 - Apr 30, 2023
    Role: Principal Investigator
    Parasite Immunity Orchestrated by Th2 Cells
    NIH/NIAID R37AI026918Jul 1, 1988 - Mar 31, 2016
    Role: Principal Investigator
    HUMAN PHAGOCYTE FUNCTION IN HEALTH AND DISEASE
    NIH/NIAID R01AI019768Sep 30, 1983 - Aug 31, 1986
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley R, Deutsch G, Sun X. Pulmonary neuroendocrine cells amplify allergic asthma responses. Science. 2018 Mar 29. PMID: 29599193.
      View in: PubMed
    2. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley R, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 Dec 14; 171(7):1707. PMID: 29245014.
      View in: PubMed
    3. Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley R, Baumjohann D, Ansel KM. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017 Dec 04; 214(12):3627-3643. PMID: 29122948.
      View in: PubMed
    4. Locksley R. Turning the light on. Nat Rev Immunol. 2017 Oct; 17(10):593. PMID: 28757606.
      View in: PubMed
    5. Savage AK, Liang HE, Locksley R. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017 09 01; 199(5):1912-1922. PMID: 28747343.
      View in: PubMed
    6. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley R, Rock JR. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 Jul 06; 21(1):120-134.e7. PMID: 28506464.
      View in: PubMed
    7. Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley R. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 Apr 20; 169(3):497-509.e13. PMID: 28431248.
      View in: PubMed
    8. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley R. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 Jan; 214(1):27-37. PMID: 28011865.
      View in: PubMed
    9. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley R, DeFranco AL. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. PMID: 27977701.
      View in: PubMed
    10. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley R. A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Dec; 17(12):1381-1387. PMID: 27749840.
      View in: PubMed
    11. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley R, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. PMID: 27453471; PMCID: PMC4985267 [Available on 08/11/17].
    12. Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley R, Klein OD. Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 Jul 07; 1(10). PMID: 27525310.
      View in: PubMed
    13. Gordon ED, Locksley R, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 05 01; 193(9):935-6. PMID: 27128698; PMCID: PMC4872659 [Available on 05/01/17].
    14. von Moltke J, Ji M, Liang HE, Locksley R. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016 Jan 14; 529(7585):221-5. PMID: 26675736; PMCID: PMC4830391.
    15. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley R. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74. PMID: 26092469; PMCID: PMC4512852.
    16. Molofsky AB, Savage AK, Locksley R. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 2015 Jun 16; 42(6):1005-19. PMID: 26084021; PMCID: PMC4471869.
    17. Seaman WE, Locksley R, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5. PMID: 25995219.
      View in: PubMed
    18. Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D. Eosinophil-specific deletion of I?Ba in mice reveals a critical role of NF-?B-induced Bcl-xL for inhibition of apoptosis. Blood. 2015 Jun 18; 125(25):3896-904. PMID: 25862560; PMCID: PMC4473117.
    19. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley R. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24. PMID: 25779634; PMCID: PMC4387286.
    20. Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley R. A novel model for IFN-?-mediated autoinflammatory syndromes. J Immunol. 2015 Mar 01; 194(5):2358-68. PMID: 25637019; PMCID: PMC4337485.
    21. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley R, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87. PMID: 25543153; PMCID: PMC4297518.
    22. Bando JK, Liang HE, Locksley R. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol. 2015 Feb; 16(2):153-60. PMID: 25501629; PMCID: PMC4297560.
    23. Cheng LE, Locksley R. Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(3):a016352. PMID: 25414367.
      View in: PubMed
    24. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley R, Bluestone JA. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 04; 124(24):3572-6. PMID: 25323825; PMCID: PMC4256909.
    25. von Moltke J, Locksley R. I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Curr Opin Immunol. 2014 Dec; 31:58-65. PMID: 25458996; PMCID: PMC4254640.
    26. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley R, Palmiter RD, Chawla A. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 2014 Jun 05; 157(6):1292-308. PMID: 24906148; PMCID: PMC4129510.
    27. Patnode ML, Bando JK, Krummel MF, Locksley R, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. PMID: 24889202; PMCID: PMC4076593.
    28. O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley R, Templeton SP. Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection. Infect Immun. 2014 Aug; 82(8):3199-205. PMID: 24842927; PMCID: PMC4136210.
    29. Locksley R, Fahy JV. Asthma and the flu: a tricky two-step. Immunol Cell Biol. 2014 May-Jun; 92(5):389-91. PMID: 24687019; PMCID: PMC4396068.
    30. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley R. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Immunity. 2014 Mar 20; 40(3):414-24. PMID: 24631157; PMCID: PMC4019510.
    31. Hams E, Locksley R, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013 Dec 01; 191(11):5349-53. PMID: 24166975.
      View in: PubMed
    32. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley R. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376; PMCID: PMC3795960.
    33. Bando JK, Nussbaum JC, Liang HE, Locksley R. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013 Nov; 94(5):877-84. PMID: 23924659; PMCID: PMC3800063.
    34. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley R, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. PMID: 23630120; PMCID: PMC4210355.
    35. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley R, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9. PMID: 23716700; PMCID: PMC3683773.
    36. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley R, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88. PMID: 23582327; PMCID: PMC3663598.
    37. Locksley R. Raggin' on T-bet. Cell Metab. 2013 Apr 02; 17(4):473-4. PMID: 23562073.
      View in: PubMed
    38. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley R. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. PMID: 23420878; PMCID: PMC3600903.
    39. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley R, McKenzie AN, Mebius RE, Powrie F, Vivier E. Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol. 2013 Feb; 13(2):145-9. PMID: 23348417.
      View in: PubMed
    40. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. J Immunol. 2013 Mar 01; 190(5):2229-40. PMID: 23338236; PMCID: PMC3683850.
    41. Van Dyken SJ, Locksley R. Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol. 2013; 31:317-43. PMID: 23298208; PMCID: PMC3606684.
    42. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. PMID: 23290520; PMCID: PMC3576928.
    43. Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley R, Le Gros G, Hermans IF. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol. 2012 Nov; 92(5):999-1009. PMID: 22941735; PMCID: PMC4050521.
    44. Price AE, Reinhardt RL, Liang HE, Locksley R. Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012; 7(6):e39750. PMID: 22768117; PMCID: PMC3387253.
    45. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. PMID: 22585735; PMCID: PMC3371730.
    46. Nussbaum JC, Locksley R. Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). PMID: 22456498; PMCID: PMC3331693.
    47. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley R. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2011 Dec 04; 13(1):58-66. PMID: 22138715; PMCID: PMC3242938.
    48. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley R, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011 Nov 20; 480(7375):104-8. PMID: 22101429; PMCID: PMC3371761.
    49. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley R, Lowell CA. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. PMID: 21918195; PMCID: PMC3186826.
    50. Fahy JV, Locksley R. The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):390-2. PMID: 21844510.
      View in: PubMed
    51. Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley R. Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol. 2011 Sep 01; 187(5):2261-7. PMID: 21824866; PMCID: PMC3159725.
    52. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley R. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. PMID: 21552267; PMCID: PMC3271435.
    53. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley R. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011 Apr 08; 332(6026):243-7. PMID: 21436399; PMCID: PMC3144160.
    54. Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley R, Chawla A. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22617-22. PMID: 21149710; PMCID: PMC3012500.
    55. Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley R, Liu L. Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol. 2010 Dec 01; 185(11):6664-9. PMID: 20980633; PMCID: PMC3070165.
    56. Cheng LE, Wang ZE, Locksley R. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 01; 185(9):5040-7. PMID: 20870945; PMCID: PMC3085987.
    57. Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley R. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11489-94. PMID: 20534524; PMCID: PMC2895098.
    58. Locksley R. Asthma and allergic inflammation. Cell. 2010 Mar 19; 140(6):777-83. PMID: 20303868; PMCID: PMC3134388.
    59. Barbalat R, Lau L, Locksley R, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol. 2009 Nov; 10(11):1200-7. PMID: 19801985; PMCID: PMC2821672.
    60. Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley R, Aguado E, Malissen M, Malissen B. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity. 2009 Aug 21; 31(2):197-208. PMID: 19682930.
      View in: PubMed
    61. Voehringer D, Wu D, Liang HE, Locksley R. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009 Jul 28; 9:69. PMID: 19638212; PMCID: PMC2724507.
    62. Locksley R. Nine lives: plasticity among T helper cell subsets. J Exp Med. 2009 Aug 03; 206(8):1643-6. PMID: 19635860; PMCID: PMC2722180.
    63. Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley R, Sher A. In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. J Immunol. 2009 Jun 01; 182(11):6915-25. PMID: 19454688.
      View in: PubMed
    64. Kroeger KM, Sullivan BM, Locksley R. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol. 2009 Oct; 86(4):769-78. PMID: 19451398; PMCID: PMC2752018.
    65. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley R, Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8. PMID: 19435888; PMCID: PMC2740590.
    66. Reinhardt RL, Liang HE, Locksley R. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol. 2009 Apr; 10(4):385-93. PMID: 19252490; PMCID: PMC2714053.
    67. Kang SJ, Locksley R. The inflammasome and alum-mediated adjuvanticity. F1000 Biol Rep. 2009 Feb 24; 1:15. PMID: 20948671; PMCID: PMC2920669.
    68. Sullivan BM, Locksley R. Basophils: a nonredundant contributor to host immunity. Immunity. 2009 Jan 16; 30(1):12-20. PMID: 19144314.
      View in: PubMed
    69. Scheu S, Dresing P, Locksley R. Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20416-21. PMID: 19088190; PMCID: PMC2629269.
    70. Kang SJ, Liang HE, Reizis B, Locksley R. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 2008 Nov 14; 29(5):819-33. PMID: 19006696; PMCID: PMC2858430.
    71. Robinson RT, Khader SA, Locksley R, Lien E, Smiley ST, Cooper AM. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol. 2008 Oct 15; 181(8):5560-7. PMID: 18832714; PMCID: PMC2640496.
    72. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley R, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85. PMID: 18832694; PMCID: PMC2657555.
    73. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 03; 135(1):37-48. PMID: 18854153; PMCID: PMC2631034.
    74. Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley R, Davis MM, Baumgarth N, Chien YH. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity. 2008 Jul 18; 29(1):90-100. PMID: 18585064; PMCID: PMC2601709.
    75. Locksley R. The Roaring Twenties. Immunity. 2008 Apr; 28(4):437-9. PMID: 18400185.
      View in: PubMed
    76. Voehringer D, Liang HE, Locksley R. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol. 2008 Apr 01; 180(7):4742-53. PMID: 18354198; PMCID: PMC2670614.
    77. Van Dyken SJ, Locksley R. Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity. Immunol Cell Biol. 2007 Nov-Dec; 85(8):572-4. PMID: 17909561.
      View in: PubMed
    78. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley R, Ahmed R, Matloubian M. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007 Aug 03; 317(5838):670-4. PMID: 17673664.
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    79. Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C. A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol. 2007 Jul 15; 179(2):1096-103. PMID: 17617602.
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    80. Launois P, Pingel S, Himmelrich H, Locksley R, Louis J. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes Infect. 2007 Sep; 9(11):1260-6. PMID: 17890126.
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    81. Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley R. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007 May 03; 447(7140):92-6. PMID: 17450126.
      View in: PubMed
    82. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley R, Haynes L, Randall TD, Cooper AM. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007 Apr; 8(4):369-77. PMID: 17351619.
      View in: PubMed
    83. Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley R. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol. 2007 Aug; 116(4):458-66. PMID: 17420014; PMCID: PMC2699772.
    84. Voehringer D, van Rooijen N, Locksley R. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol. 2007 Jun; 81(6):1434-44. PMID: 17339609.
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    85. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley R, Lowell CA, Caughey GH. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. PMID: 17158962; PMCID: PMC2118183.
    86. Locksley R. A failure to launch: fuelling cytokine secretion in iNKT cells. Immunity. 2006 Sep; 25(3):393-5. PMID: 16979571.
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    87. Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley R. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol. 2006 Aug 01; 177(3):1618-27. PMID: 16849470.
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    88. Fife BT, Griffin MD, Abbas AK, Locksley R, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006 Aug; 116(8):2252-61. PMID: 16886063; PMCID: PMC1523399.
    89. Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley R, MacDonald HR, Launois P, Louis J. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur J Immunol. 2006 Jun; 36(6):1465-73. PMID: 16637008.
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    90. Voehringer D, Reese TA, Huang X, Shinkai K, Locksley R. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006 Jun 12; 203(6):1435-46. PMID: 16702603; PMCID: PMC2118302.
    91. Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley R. Activation of the integrated stress response during T helper cell differentiation. Nat Immunol. 2006 Jun; 7(6):644-51. PMID: 16680145.
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    92. Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley R, Giacca M, Masai H, Miyatake S. Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence. J Immunol. 2006 May 01; 176(9):5446-54. PMID: 16622012.
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    93. Reinhardt RL, Kang SJ, Liang HE, Locksley R. T helper cell effector fates--who, how and where? Curr Opin Immunol. 2006 Jun; 18(3):271-7. PMID: 16617008.
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    94. Veldhoen M, Hocking RJ, Atkins CJ, Locksley R, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006 Feb; 24(2):179-89. PMID: 16473830.
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    95. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley R, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92. PMID: 16311599; PMCID: PMC3057888.
    96. Im W, Kim H, Yun D, Seo SY, Park SH, Locksley R, Hong S. Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Mol Cells. 2005 Oct 31; 20(2):288-96. PMID: 16267405.
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    97. Mohrs K, Wakil AE, Killeen N, Locksley R, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity. 2005 Oct; 23(4):419-29. PMID: 16226507; PMCID: PMC2826320.
    98. Loke P, Zang X, Hsuan L, Waitz R, Locksley R, Allen JE, Allison JP. Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9872-7. PMID: 15994233; PMCID: PMC1175004.
    99. Ohmura K, Nguyen LT, Locksley R, Mathis D, Benoist C. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum. 2005 Jun; 52(6):1866-75. PMID: 15934072.
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    100. Kelly BL, Locksley R. The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice. Infect Immun. 2004 Dec; 72(12):6924-31. PMID: 15557613; PMCID: PMC529165.
    101. Voehringer D, Rosen DB, Lanier LL, Locksley R. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem. 2004 Dec 24; 279(52):54117-23. PMID: 15471863.
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    102. Xu M, Wang Z, Locksley R. Innate immune responses in peptidoglycan recognition protein L-deficient mice. Mol Cell Biol. 2004 Sep; 24(18):7949-57. PMID: 15340057; PMCID: PMC515053.
    103. Voehringer D, Shinkai K, Locksley R. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 2004 Mar; 20(3):267-77. PMID: 15030771.
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    104. Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley R. Th2 cells: orchestrating barrier immunity. Adv Immunol. 2004; 83:163-89. PMID: 15135631.
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    105. Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley R. Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol. 2003 Dec 15; 171(12):6672-9. PMID: 14662870.
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    106. Kelly BL, Stetson DB, Locksley R. Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med. 2003 Dec 01; 198(11):1689-98. PMID: 14657221; PMCID: PMC2194132.
    107. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley R. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med. 2003 Oct 06; 198(7):1069-76. PMID: 14530376; PMCID: PMC2194220.
    108. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley R, Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8395-400. PMID: 12829795; PMCID: PMC166240.
    109. Hadeiba H, Locksley R. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol. 2003 Jun 01; 170(11):5502-10. PMID: 12759427.
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    110. Mohrs M, Lacy DA, Locksley R. Stat signals release activated naive Th cells from an anergic checkpoint. J Immunol. 2003 Feb 15; 170(4):1870-6. PMID: 12574353.
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    111. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley R, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol. 2003 Feb; 4(2):182-8. PMID: 12524538.
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    112. Shinkai K, Mohrs M, Locksley R. Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002 Dec 19-26; 420(6917):825-9. PMID: 12490951.
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    113. Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley R. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity. 2002 Aug; 17(2):191-200. PMID: 12196290.
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    114. Locksley R. Blood lines. Nat Immunol. 2002 Aug; 3(8):705-6. PMID: 12145653.
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    115. Grogan JL, Locksley R. T helper cell differentiation: on again, off again. Curr Opin Immunol. 2002 Jun; 14(3):366-72. PMID: 11973136.
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    116. Launois P, Gumy A, Himmelrich H, Locksley R, Röcken M, Louis JA. Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions. J Immunol. 2002 May 01; 168(9):4628-35. PMID: 11971011.
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    117. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94. PMID: 11970881.
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    118. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 2001 Dec; 15(6):909-19. PMID: 11754813.
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    119. Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun. 2001 May; 69(5):3232-9. PMID: 11292745; PMCID: PMC98281.
    120. Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM. Functional screening of an asthma QTL in YAC transgenic mice. Nat Genet. 1999 Oct; 23(2):241-4. PMID: 10508526.
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    121. Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M. Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J Immunol. 1998 Apr 15; 160(8):3681-8. PMID: 9558068.
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