Rosalyn Sayaman, PhD

Title(s)Assistant Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #N415
San Francisco CA 94143
PronounsHe/She
ORCID ORCID Icon0000-0003-1343-0619 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, Berkeley, CAPhD12/2016Comparative Biochemistry
    California Institute of Technology, Pasadena, CAMS06/2010Bioengineering
    University of California, Berkeley, Berkeley, CABA12/2001Integrative Biology
    Collapse Awards and Honors
    National Cancer Institute (NCI)2023  - 2028NCI K01 Mentored Research Scientist Development Award to Promote Diversity
    National Institute on Aging (NIA)2021Butler-Williams Scholar Program
    San Antonio Breast Cancer Symposium (SABCS)2019American Association for Cancer Research (AACR) Associate Award Merit Recipient
    Society for Immunotherapy of Cancer (SITC)2019Young Investigator Award
    Beckman Research Institute, City of Hope Comprehensive Cancer Center2018  - 2020NIH T32 Cancer Metabolism Training Grant Postdoctoral Fellowship
    Berkeley Stem Cell Center, University of California, Berkeley2012  - 2014NIH T32 Stem Cell Engineering Training Grant Graduate Fellowship
    University of California, Berkeley2011  - 2015Chancellor’s Fellowship for Graduate Research

    Collapse Research 
    Collapse Research Activities and Funding
    A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer
    NIH/NCI K01CA279498Aug 4, 2023 - Jul 31, 2028
    Role: Principal Investigator
    Description: The I-SPY 2 neoadjuvant breast cancer clinical trial is a personalized, adaptive trial designed to improve outcomes in high-risk breast cancer patients. This study seeks to develop computational and machine learning (ML) models to unravel the complex interactions between intrinsic host germline and tumor somatic mutations, and extrinsic tumor microenvironment features that drive the biology of response or resistance to therapy. Our study will leverage parallel transcriptomic, genomic, and fluorescence imaging data in the I-SPY2 trial to generate genomic and tumor microenvironment response-predictive biomarkers. Our study aims to improve on current qualifying biomarkers – providing better stratification of patients and directing them to best predicted interventions – and that identify possible alternative treatment strategies for non-responders – reducing unnecessary therapeutic burden.
    The I SPY 2.2 TRIAL: Evolving to Imaging and Molecular Biomarker Response Directed Adaptive Sequential Treatment to Optimize Breast Cancer Outcomes
    NIH/NCI P01CA210961Jul 1, 2023 - Jun 30, 2028
    Role: Co-Investigator
    Description: We have designed a clinical trial for women treated with drugs for early breast cancer before surgery, in which patients whose cancers do not respond to the initial experimental treatment can be switched to receive a different proven therapy that is considered the best for their particular type of cancer. Our goal is to develop a system that continuously improves our ability to provide each woman with the best chance at being cured, while also trying to avoid any unnecessary treatments that cause toxic side effects.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility. Elife. 2024 Nov 15; 13. Sayaman RW, Miyano M, Carlson EG, Senapati P, Zirbes A, Shalabi SF, Todhunter ME, Seewaldt VE, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA. PMID: 39545637; PMCID: PMC11723586.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Transcriptomic analysis of the 12 major human breast cell types reveals mechanisms of cell and tissue function. PLoS Biol. 2024 Nov; 22(11):e3002820. Del Toro K, Sayaman R, Thi K, Licon-Munoz Y, Hines WC. PMID: 39499736; PMCID: PMC11537416.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 + cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype. bioRxiv. 2024 Sep 25. Arcuschin CD, Kahrizi K, Sayaman RW, DiBenedetto C, Shen Y, Salaberry PJ, Zakroui O, Schwarzer C, Scapozza A, Betancur P, Saba JD, Coppé JP, Barcellos-Hoff MH, Kappes D, van 't Veer L, Schor IE, Muñoz DP. PMID: 39386673; PMCID: PMC11463473.
      View in: PubMed   Mentions:
    4. Comprehensive identification, isolation, and culture of human breast cell types. J Biol Chem. 2024 Oct; 300(10):107637. Thi K, Del Toro K, Licon-Munoz Y, Sayaman RW, Hines WC. PMID: 39122004; PMCID: PMC11459906.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy. Clin Cancer Res. 2024 Jun 03; 30(11):2444-2451. Magbanua MJM, Ahmed Z, Sayaman RW, Brown Swigart L, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Perlmutter J, Pohlmann P, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ. PMID: 38470545; PMCID: PMC11147708.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells. Genome Res. 2023 08; 33(8):1229-1241. Senapati P, Miyano M, Sayaman RW, Basam M, Leung A, LaBarge MA, Schones DE. PMID: 37463750; PMCID: PMC10547379.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. An integrated tumor, immune and microbiome atlas of colon cancer. Nat Med. 2023 05; 29(5):1273-1286. Roelands J, Kuppen PJK, Ahmed EI, Mall R, Masoodi T, Singh P, Monaco G, Raynaud C, de Miranda NFCC, Ferraro L, Carneiro-Lobo TC, Syed N, Rawat A, Awad A, Decock J, Mifsud W, Miller LD, Sherif S, Mohamed MG, Rinchai D, Van den Eynde M, Sayaman RW, Ziv E, Bertucci F, Petkar MA, Lorenz S, Mathew LS, Wang K, Murugesan S, Chaussabel D, Vahrmeijer AL, Wang E, Ceccarelli A, Fakhro KA, Zoppoli G, Ballestrero A, Tollenaar RAEM, Marincola FM, Galon J, Khodor SA, Ceccarelli M, Hendrickx W, Bedognetti D. PMID: 37202560; PMCID: PMC10202816.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    8. Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy. Cancer Cell. 2023 06 12; 41(6):1091-1102.e4. Magbanua MJM, Brown Swigart L, Ahmed Z, Sayaman RW, Renner D, Kalashnikova E, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Asare S, Liu MC, Albain K, Chien AJ, Forero-Torres A, Isaacs C, Nanda R, Tripathy D, Rodriguez A, Sethi H, Aleshin A, Rabinowitz M, Perlmutter J, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ. PMID: 37146605; PMCID: PMC10330514.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    9. Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors. STAR Protoc. 2022 12 16; 3(4):101809. Sayaman RW, Saad M, Heimann C, Hu D, Kunji K, Roelands J, Wolf DM, Huntsman S, Ceccarelli M, Thorsson V, Ziv E, Bedognetti D. PMID: 36595917; PMCID: PMC9772839.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Analysis of germline-driven ancestry-associated gene expression in cancers. STAR Protoc. 2022 09 16; 3(3):101586. Chambwe N, Sayaman RW, Hu D, Huntsman S, Cancer Genome Analysis Network, Kemal A, Caesar-Johnson S, Zenklusen JC, Ziv E, Beroukhim R, Cherniack AD. PMID: 35942349; PMCID: PMC9356164.
      View in: PubMed   Mentions: 1     Fields:    
    11. Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies. Cancer Cell. 2022 06 13; 40(6):609-623.e6. Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J, I-SPY2 Investigators, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ. PMID: 35623341; PMCID: PMC9426306.
      View in: PubMed   Mentions: 89     Fields:    
    12. Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations. Nat Aging. 2021 09; 1(9):838-849. Shalabi SF, Miyano M, Sayaman RW, Lopez JC, Jokela TA, Todhunter ME, Hinz S, Garbe JC, Stampfer MR, Kessenbrock K, Seewaldt VE, LaBarge MA. PMID: 35187501; PMCID: PMC8849557.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    13. Deep proteome profiling of human mammary epithelia at lineage and age resolution. iScience. 2021 Sep 24; 24(9):103026. Hinz S, Manousopoulou A, Miyano M, Sayaman RW, Aguilera KY, Todhunter ME, Lopez JC, Sohn LL, Wang LD, LaBarge MA. PMID: 34522866; PMCID: PMC8426267.
      View in: PubMed   Mentions: 4  
    14. Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression. J Mammary Gland Biol Neoplasia. 2021 09; 26(3):247-261. Zirbes A, Joseph J, Lopez JC, Sayaman RW, Basam M, Seewaldt VL, LaBarge MA. PMID: 34341887; PMCID: PMC8566425.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation. Cancer Prev Res (Phila). 2021 08; 14(8):779-794. Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA. PMID: 34140348; PMCID: PMC8338914.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Volume-constrained microcontainers enable myoepithelial functional differentiation in highly parallel mammary organoid culture. iScience. 2021 Apr 23; 24(4):102253. Todhunter ME, Miyano M, Moolamalla DS, Filippov A, Sayaman RW, LaBarge MA. PMID: 33796842; PMCID: PMC7995530.
      View in: PubMed   Mentions: 3  
    17. Epigenetic changes with age primes mammary luminal epithelia for cancer initiation. bioRxiv. 2021. Sayaman RW, Miyano M, Senapati P, Shalabi S, Zirbes A, Todhunter ME, Seewaldt V, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA. View Publication.
    18. Germline genetic contribution to the immune landscape of cancer. Immunity. 2021 02 09; 54(2):367-386.e8. Sayaman RW, Saad M, Thorsson V, Hu D, Hendrickx W, Roelands J, Porta-Pardo E, Mokrab Y, Farshidfar F, Kirchhoff T, Sweis RF, Bathe OF, Heimann C, Campbell MJ, Campbell MJ, Stretch C, Huntsman S, Graff RE, Syed N, Radvanyi L, Shelley S, Wolf D, Marincola FM, Ceccarelli M, Galon J, Ziv E, Bedognetti D. PMID: 33567262; PMCID: PMC8414660.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    19. Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry. NPJ Breast Cancer. 2021 Feb 08; 7(1):10. Roelands J, Mall R, Almeer H, Thomas R, Mohamed MG, Bedri S, Al-Bader SB, Junejo K, Ziv E, Sayaman RW, Kuppen PJK, Bedognetti D, Hendrickx W, Decock J. PMID: 33558495; PMCID: PMC7870839.
      View in: PubMed   Mentions: 14  
    20. The landscape of interactions between cancer polygenic risk scores and somatic alterations in cancer cells. bioRxiv. 2020. Porta-Pardo E, Sayaman RW, Ziv E, Valencia A. View Publication.
    21. Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer. Cancer Cell. 2020 05 11; 37(5):639-654.e6. Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E, Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R. PMID: 32396860; PMCID: PMC7328015.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    22. Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications. Front Oncol. 2019; 9:1328. Shan J, Chouchane A, Mokrab Y, Saad M, Boujassoum S, Sayaman RW, Ziv E, Bouaouina N, Remadi Y, Gabbouj S, Roelands J, Ma X, Bedognetti D, Chouchane L. PMID: 31921621; PMCID: PMC6915105.
      View in: PubMed   Mentions: 8  
    23. Tissue aging: the integration of collective and variant responses of cells to entropic forces over time. Curr Opin Cell Biol. 2018 10; 54:121-129. Todhunter ME, Sayaman RW, Miyano M, LaBarge MA. PMID: 29908481; PMCID: PMC6258070.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    24. Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells. Aging (Albany NY). 2017 10 09; 9(10):2026-2051. Miyano M, Sayaman RW, Stoiber MH, Lin CH, Stampfer MR, Brown JB, LaBarge MA. PMID: 29016359; PMCID: PMC5680554.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. Discriminating external and internal causes for heading changes in freely flying Drosophila. PLoS Comput Biol. 2013; 9(2):e1002891. Censi A, Straw AD, Sayaman RW, Murray RM, Dickinson MH. PMID: 23468601; PMCID: PMC3585425.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    26. The aerodynamics of hovering flight in Drosophila. J Exp Biol. 2005 Jun; 208(Pt 12):2303-18. Fry SN, Sayaman R, Dickinson MH. PMID: 15939772.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    27. The aerodynamics of free-flight maneuvers in Drosophila. Science. 2003 Apr 18; 300(5618):495-8. Fry SN, Sayaman R, Dickinson MH. PMID: 12702878.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
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