Paola Betancur, PhD

Title(s)Assistant Professor, Radiation Oncology
SchoolSchool of Medicine
Address2340 Sutter Street, #001
San Francisco CA 94115
ORCID ORCID Icon0000-0001-9011-4746 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, CA2020Diversity, Equity and Inclusion Champion Training
    Stanford University, CAPost-doctoral fellowship2017Cancer Immunology
    California Institute of Technology, CAPhD2010Cell Biology
    Stony Brook University, NYBS2003Biology

    Collapse Overview 
    Collapse Overview
    We are interested in understanding the mechanisms encoded in the DNA by which cancerous cells avoid being detected and destroyed by the host’s immune system. Toward this goal, we examine the interactions between epigenetic modifiers, transcription factors and the genomic enhancers of target genes that in response to inflammation abnormally activate the immune escape program within tumor or damaged cells during aging, after radiation and in response to infectious diseases. To accomplish our goal, we have long lasting collaborations across campus, at Stanford University and other recognized national and international institutions.
    With patients in mind, we are a research group dedicated to finding methods for improving the treatment of cancer by analyzing the DNA of individual patients. In the era of personalized medicine, this information is critical for understanding which therapy will be more effective for each patient, and for targeting specific cancer types, including cancer of the breast.
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    Collapse Research 
    Collapse Research Activities and Funding
    Identification of Novel Gene Regulatory Interactions Driving the Immune Evasion Program Through Transcriptional Activation of CD47 in Cancer
    NIH K22CA226365Sep 1, 2019 - Aug 31, 2022
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abstract 4402: A genomic insertion/deletion variant activates immune escape and tumor promoting programs in breast cancer. Cancer Research. 2024 Mar 22; 84(6_Supplement):4402-4402. Betancur BP, DiBenedetto DC, Acenas AD, Rodriguez RA, Thach TA. .
      View in: Publisher Site   Mentions:
    2. High-resolution Inference of Multiplexed Anti-HIV Gene Editing using Single-Cell Targeted DNA Sequencing. bioRxiv. 2024 Jan 24. Bouzidi MS, Dossani ZY, Di Benedetto C, Raymond KA, Desai S, Chavez LR, Betancur P, Pillai SK. PMID: 38328062; PMCID: PMC10849705.
      View in: PubMed   Mentions:
    3. Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis. Cancers (Basel). 2023 Feb 03; 15(3). Di Benedetto C, Khan T, Serrano-Saenz S, Rodriguez-Lemus A, Klomsiri C, Beutel TM, Thach A, Walczak H, Betancur P. PMID: 36765925; PMCID: PMC9913803.
      View in: PubMed   Mentions:
    4. NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer. BMC Cancer. 2022 Oct 12; 22(1):1056. Di Benedetto C, Oh J, Choudhery Z, Shi W, Valdes G, Betancur P. PMID: 36224576; PMCID: PMC9555101.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nat Commun. 2020 06 03; 11(1):2795. Cui L, Chen SY, Lerbs T, Lee JW, Domizi P, Gordon S, Kim YH, Nolan G, Betancur P, Wernig G. PMID: 32493933; PMCID: PMC7270081.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    6. A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Nat Commun. 2017 04 05; 8:14802. Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, Ho P, Gip P, Swigut T, Sherwood RI, Clarke MF, Somlo G, Young RA, Weissman IL. PMID: 28378740; PMCID: PMC5382276.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    7. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016 08 04; 536(7614):86-90. Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. PMID: 27437576; PMCID: PMC4980260.
      View in: PubMed   Mentions: 262     Fields:    Translation:HumansAnimalsCells
    8. Expression and function of transcription factor cMyb during cranial neural crest development. Mech Dev. 2014 May; 132:38-43. Betancur P, Simões-Costa M, Sauka-Spengler T, Bronner ME. PMID: 24509349; PMCID: PMC3987950.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    9. A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogs. Development. 2011 Sep; 138(17):3689-98. Betancur P, Sauka-Spengler T, Bronner M. PMID: 21775416; PMCID: PMC3152925.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    10. Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crest. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3570-5. Betancur P, Bronner-Fraser M, Sauka-Spengler T. PMID: 20139305; PMCID: PMC2840498.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    11. Assembling neural crest regulatory circuits into a gene regulatory network. Annu Rev Cell Dev Biol. 2010; 26:581-603. Betancur P, Bronner-Fraser M, Sauka-Spengler T. PMID: 19575671; PMCID: PMC4040144.
      View in: PubMed   Mentions: 139     Fields:    Translation:Animals
    12. c-Myb, Ets-1 and Sox9 directly activate a Sox10 core enhancer in delaminating cranial neural crest. Developmental Biology. 2009 Jul 1; 331(2):438. Betancur BP, Sauka-Spengler ST, Bronner-Fraser BM. .
      View in: Publisher Site   Mentions:
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