Laura Huppert, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address550 16th Street, #6570
San Francisco CA 94158
Phone415-476-2378
PronounsShe/Her/Hers
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    Collapse Biography 
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    Harvard Medical SchoolMD2015
    UCSFResidency2018Internal Medicine
    UCSFFellowship2022Hematology/Oncology

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    Dr. Laura Huppert is an oncologist who cares for patients with all stages of breast cancer.

    Huppert's research focuses on designing and conducting clinical trials to evaluate new cancer treatments, including ways to combine therapies so as to improve outcomes. She also studies metastatic breast cancer (that has spread to other body parts), including cancer that has reached the brain and leptomeninges (membranes surrounding the brain and spinal cord), and works to translate findings from the lab into care provided to patients.

    Huppert earned her medical degree at Harvard Medical School. She completed a residency in internal medicine and a fellowship in hematology and oncology at UCSF. She is a member of the American Society of Clinical Oncology (ASCO) and has received an ASCO Merit Award as well as grants from the California Breast Cancer Research Program.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T-cell Subpopulation That Is Correlated with Response to Checkpoint Therapy in Melanoma. Cancer Res. 2025 Apr 15; 85(8):1424-1440. Mahuron KM, Shahid O, Sao P, Wu C, Haugh AM, Huppert LA, Levine LS, Lowe MM, Alvarado M, Micu M, Tsai KK, Chow M, Singer M, Schenkel JM, Sharpe AH, Rosenblum MD, Pauken KE, Daud AI. PMID: 40042995.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC). NPJ Breast Cancer. 2025 Apr 15; 11(1):34. Huppert LA, Mahtani R, Fisch S, Dempsey N, Premji S, Raimonde A, Jacob S, Quintal L, Melisko M, Chien J, Sandoval A, Carcas L, Ahluwalia M, Harpalani N, Hoppenworth J, Blaes A, Blum K, Kim MO, Idossa D, Rao R, Giridhar KV, Rugo HS. PMID: 40234477; PMCID: PMC12000457.
      View in: PubMed   Mentions: 1  
    3. Association of lower tumor mutation burden with rapid local progression in patients with brain metastases. J Neurosurg. 2025 Jun 01; 142(6):1701-1709. Shukla PD, Nguyen MP, Lui A, Catalan T, Young JS, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Huppert LA, Aghi MK, Vasudevan HN, Morshed RA. PMID: 39951711.
      View in: PubMed   Mentions:    Fields:    
    4. Implantation of engineered adipocytes suppresses tumor progression in cancer models. Nat Biotechnol. 2025 Feb 04. Nguyen HP, An K, Ito Y, Kharbikar BN, Sheng R, Paredes B, Murray E, Pham K, Bruck M, Zhou X, Biellak C, Ushiki A, Nobuhara M, Fong SL, Bernards DA, Lynce F, Dillon DA, Magbanua MJM, Huppert LA, Hammerlindl H, Klein JA, Valdiviez L, Fiehn O, Esserman L, Desai TA, Yee SW, Rosenbluth JM, Ahituv N. PMID: 39905264.
      View in: PubMed   Mentions: 2     Fields:    
    5. Hormone Receptor-Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers. Clin Cancer Res. 2025 Jan 17; 31(2):403-413. Rios-Hoyo A, Xiong K, Dai J, Yau C, Marczyk M, Garcia-Milian R, Wolf DM, Huppert LA, Nanda R, Hirst GL, Cobain EF, van 't Veer LJ, Esserman LJ, Pusztai L. PMID: 39561272; PMCID: PMC11747811.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Pathologic complete response (pCR) rates for patients with HR+/HER2- high-risk, early-stage breast cancer (EBC) by clinical and molecular features in the phase II I-SPY2 clinical trial. Ann Oncol. 2025 Feb; 36(2):172-184. Huppert LA, Wolf D, Yau C, Brown-Swigart L, Hirst GL, Isaacs C, Pusztai L, Pohlmann PR, DeMichele A, Shatsky R, Yee D, Thomas A, Nanda R, Perlmutter J, Heditsian D, Hylton N, Symmans F, Van't Veer LJ, Esserman L, Rugo HS. PMID: 39477071.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    7. Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial. Nat Med. 2024 Dec; 30(12):3737-3747. Shatsky RA, Trivedi MS, Yau C, Nanda R, Rugo HS, Davidian M, Tsiatis B, Wallace AM, Chien AJ, Stringer-Reasor E, Boughey JC, Omene C, Rozenblit M, Kalinsky K, Elias AD, Vaklavas C, Beckwith H, Williams N, Arora M, Nangia C, Roussos Torres ET, Thomas B, Albain KS, Clark AS, Falkson C, Hershman DL, Isaacs C, Thomas A, Tseng J, Sanford A, Yeung K, Boles S, Chen YY, Huppert L, Jahan N, Parker C, Giridhar K, Howard FM, Blackwood MM, Sanft T, Li W, Onishi N, Asare AL, Beineke P, Norwood P, Brown-Swigart L, Hirst GL, Matthews JB, Moore B, Symmans WF, Price E, Heditsian D, LeStage B, Perlmutter J, Pohlmann P, DeMichele A, Yee D, van 't Veer LJ, Hylton NM, Esserman LJ. PMID: 39277672; PMCID: PMC12089997.
      View in: PubMed   Mentions: 7     Fields:    Translation:CTClinical Trials
    8. Phase II trial of pembrolizumab, ipilimumab, and aspirin in melanoma: clinical outcomes and translational predictors of response. BJC Rep. 2024 Jun 24; 2(1):46. Quandt Z, Jacob S, Fadlullah MZH, Wu C, Wu C, Huppert L, Levine LS, Sison P, Tsai KK, Chow M, Kang JH, Hwang J, Lee JC, Oglesby A, Venegas J, Brintz BJ, Tan AC, Anderson MS, Rosenblum MD, Young A, Daud AI. PMID: 39516257; PMCID: PMC11524064.
      View in: PubMed   Mentions: 2  
    9. Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study. Breast Cancer Res Treat. 2024 Aug; 206(3):625-636. Huppert LA, Fisch S, Tsopurashvili E, Somepalle SS, Salans M, Vasudevan HN, Jo Chien A, Majure M, Rugo HS, Balassanian R, Boreta L, Melisko ME. PMID: 38888796; PMCID: PMC11208257.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Neoadjuvant Chemotherapy and Immunotherapy for Estrogen Receptor-Positive Human Epidermal Growth Factor 2-Negative Breast Cancer. J Clin Oncol. 2024 Aug 01; 42(22):2632-2636. Ríos-Hoyo A, Cobain E, Huppert LA, Beitsch PD, Buchholz TA, Esserman L, van 't Veer LJ, Rugo HS, Pusztai L. PMID: 38593393.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs). Curr Ophthalmol Rep. 2024 Jun; 12(2):13-22. Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND. PMID: 38756824; PMCID: PMC11095972.
      View in: PubMed   Mentions: 1  
    12. Changes in Gender and Racial/Ethnic Diversity in US Residency Program Applications From 2018 to 2022. J Grad Med Educ. 2024 Feb; 16(1):37-40. Huppert LA, Santhosh L, Alba-Nguyen S, Lai CJ, Babik JM. PMID: 38304603; PMCID: PMC10829929.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    13. Characterizing attitudes related to future child-bearing in young women diagnosed with early-stage breast cancer. Breast Cancer Res Treat. 2024 Apr; 204(3):509-520. Umashankar S, Li M, Blevins K, Kim MO, Majure M, Park J, Huppert LA, Melisko M, Rugo HS, Esserman L, Chien AJ. PMID: 38194132; PMCID: PMC10959837.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Can We De-escalate Therapy for HER2-Positive Metastatic Breast Cancer? Clin Cancer Res. 2023 12 15; 29(24):4993-4995. Huppert LA, Rugo HS. PMID: 37782311.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Tamoxifen or aromatase inhibitors with ovarian function suppression in pre-menopausal stage I-III lobular breast cancer. NPJ Breast Cancer. 2023 Oct 26; 9(1):88. Record H, Clelland E, Rothschild HT, Kaur M, Chien AJ, Melisko M, Rugo HS, Mujir F, Huppert L, Mukhtar RA. PMID: 37884561; PMCID: PMC10603127.
      View in: PubMed   Mentions: 1  
    16. Letter to the Editor of Annals of Surgical Oncology concerning "Is Choosing Wisely Wise for Lobular Carcinoma in Patients over 70 Years of Age? A National Cancer Database Analysis of Sentinel Node Practice Patterns". Ann Surg Oncol. 2024 01; 31(1):401-402. Mukhtar RA, Huppert L, Ramalingam K. PMID: 37851197.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. A phase Ib/II study of eribulin in combination with cyclophosphamide in patients with advanced breast cancer. Breast Cancer Res Treat. 2024 Jan; 203(2):197-204. Gumusay O, Huppert LA, Magbanua MJM, Wabl CA, Assefa M, Chien AJ, Melisko ME, Majure MC, Moasser M, Park J, Rugo HS. PMID: 37815684; PMCID: PMC10787873.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    18. Metabolic Positron Emission Tomography in Breast Cancer. PET Clin. 2023 Oct; 18(4):473-485. Cecil K, Huppert L, Mukhtar R, Dibble EH, O'Brien SR, Ulaner GA, Lawhn-Heath C. PMID: 37369614.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Invited Commentary: Can We De-Escalate More Than 1 Breast Cancer Treatment Modality at the Same Time? J Am Coll Surg. 2023 08 01; 237(2):256-258. Tasoulis MK, Huppert LA. PMID: 37199440.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease. NPJ Breast Cancer. 2023 Apr 07; 9(1):22. Im KW, Huppert LA, Malevanchik L, Rugo HS, Combes AJ, Campbell MJ, Krummel MF, Melisko ME. PMID: 37029150; PMCID: PMC10082042.
      View in: PubMed   Mentions: 3  
    21. Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression. bioRxiv. 2023 Mar 29. Nguyen HP, Sheng R, Murray E, Ito Y, Bruck M, Biellak C, An K, Lynce F, Dillon DA, Magbanua MJM, Huppert LA, Hammerlindl H, Esserman L, Rosenbluth JM, Ahituv N. PMID: 37034710; PMCID: PMC10081280.
      View in: PubMed   Mentions:
    22. Systemic therapy for hormone receptor-positive/human epidermal growth factor receptor 2-negative early stage and metastatic breast cancer. CA Cancer J Clin. 2023 Sep-Oct; 73(5):480-515. Huppert LA, Gumusay O, Idossa D, Rugo HS. PMID: 36939293.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    23. Osimertinib in NSCLC With Atypical EGFR-Activating Mutations: A Retrospective Multicenter Study. JTO Clin Res Rep. 2023 Mar; 4(3):100459. Ji J, Aredo JV, Piper-Vallillo A, Huppert L, Rotow JK, Husain H, Stewart S, Cobb R, Wakelee HA, Blakely CM, Wong ML, Gubens MA, Madani MH, Digumarthy SR, McCoach C, Piotrowska Z, Neal JW, Riess JW. PMID: 36879929; PMCID: PMC9984841.
      View in: PubMed   Mentions: 17  
    24. Role of Immunotherapy in Breast Cancer. JCO Oncol Pract. 2023 04; 19(4):167-179. Jacob SL, Huppert LA, Rugo HS. PMID: 36608303.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    25. Clinical characteristics and outcomes in patients with metastatic breast cancer and pseudocirrhosis: a single center retrospective cohort study. Breast Cancer Res Treat. 2023 Jan; 197(1):137-148. Huppert LA, Walker Z, Li M, Kim MO, Callan J, Brandman D, Majure M, Melisko ME, Rugo HS, Behr S, Chien AJ. PMID: 36319907.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    26. Intratumoral therapies and in-situ vaccination for melanoma. Hum Vaccin Immunother. 2022 05 31; 18(3):1890512. Huppert LA, Daud AI. PMID: 35559766; PMCID: PMC9116417.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    27. Emerging treatment strategies for metastatic triple-negative breast cancer. Ther Adv Med Oncol. 2022; 14:17588359221086916. Huppert LA, Gumusay O, Rugo HS. PMID: 35422881; PMCID: PMC9003656.
      View in: PubMed   Mentions: 18  
    28. The role of percutaneous vertebral augmentation in patients with metastatic breast cancer: Literature review including report of two cases. Breast. 2022 Jun; 63:149-156. Gumusay O, Huppert LA, Behr SC, Rugo HS. PMID: 35397256; PMCID: PMC8991318.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Tumor Fever Due to Metastatic Esophageal Squamous Cell Carcinoma. Am J Med. 2022 08; 135(8):e294-e295. Isaza E, Huppert LA, Lai AR, Brondfield S. PMID: 35367183.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Development and Evaluation of a Five-Component Toolkit for Internal Medicine Residents Applying for Subspecialty Fellowships. MedEdPORTAL. 2022; 18:11228. Huppert LA, Babik JM. PMID: 35342791; PMCID: PMC8918571.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs. Med Educ Online. 2021 Dec; 26(1):1946237. Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM. PMID: 34187346; PMCID: PMC8253192.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    32. Emerging immunotherapeutic strategies for the treatment of breast cancer. Breast Cancer Res Treat. 2022 Jan; 191(2):243-255. Huppert LA, Mariotti V, Chien AJ, Soliman HH. PMID: 34716870.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Letter to the Editor: The Effect of COVID-19 on the Orthopaedic Surgery Residency Application Process. J Am Acad Orthop Surg. 2023 02 01; 31(3):e130-e132. Roberts HJ, Huppert LA. PMID: 34534189.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy. Cell Mol Immunol. 2022 01; 19(1):33-45. Huppert LA, Green MD, Kim L, Chow C, Leyfman Y, Daud AI, Lee JC. PMID: 34417572; PMCID: PMC8752797.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    35. The Liver-Immunity Nexus and Cancer Immunotherapy. Clin Cancer Res. 2022 01 01; 28(1):5-12. Lee JC, Green MD, Huppert LA, Chow C, Pierce RH, Daud AI. PMID: 34285059; PMCID: PMC8897983.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    36. Pembrolizumab and Ipilimumab as Second-Line Therapy for Advanced Melanoma. J Clin Oncol. 2021 08 20; 39(24):2637-2639. Huppert LA, Daud AI. PMID: 34138634.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Answers Are in the Blood: cfDNA to Enhance Precision Medicine for Breast Cancer. Clin Cancer Res. 2021 06 15; 27(12):3275-3277. Rugo HS, Huppert L. PMID: 33837007.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Trends in US Internal Medicine Residency and Fellowship Applications During the COVID-19 Pandemic vs Previous Years. JAMA Netw Open. 2021 04 01; 4(4):e218199. Huppert LA, Santhosh L, Babik JM. PMID: 33909057; PMCID: PMC8082322.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsPHPublic Health
    39. Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices. Acad Med. 2021 08 01; 96(8):1137-1145. Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM. PMID: 33298691.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansPHPublic Health
    40. Best Practices to Successfully Navigate a Virtual Interview: a Five-Step Guide for Hematology/Oncology Fellowship Applicants. J Cancer Educ. 2020 10; 35(5):860-861. Huppert LA, Babik JM. PMID: 32808251; PMCID: PMC7431280.
      View in: PubMed   Mentions:    Fields:    
    41. Treatment of Metastatic Melanoma With Leptomeningeal Disease Using Intrathecal Immunotherapy. JCO Oncol Pract. 2020 11; 16(11):757-759. Huppert LA, Melisko ME, Glastonbury CM, Khanafshar E, Daud AI. PMID: 32603255.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    42. Checkpoint Inhibitors for the Treatment of Advanced Hepatocellular Carcinoma. Clin Liver Dis (Hoboken). 2020 Feb; 15(2):53-58. Huppert LA, Gordan JD, Kelley RK. PMID: 32226615; PMCID: PMC7098670.
      View in: PubMed   Mentions: 16  
    43. Prognostic Biomarkers for Melanoma Immunotherapy. Curr Oncol Rep. 2020 02 11; 22(3):25. Twitty CG, Huppert LA, Daud AI. PMID: 32048065.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. Pathogenesis of Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med. 2019 02; 40(1):31-39. Huppert LA, Matthay MA, Ware LB. PMID: 31060086; PMCID: PMC7060969.
      View in: PubMed   Mentions: 220     Fields:    Translation:HumansCells
    45. Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS. Transfusion. 2019 02; 59(S1):869-875. Huppert LA, Liu KD, Matthay MA. PMID: 30383290.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    46. Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Front Immunol. 2017; 8:371. Huppert LA, Matthay MA. PMID: 28439268; PMCID: PMC5383664.
      View in: PubMed   Mentions: 40     Fields:    
    47. Linked domain architectures allow for specialization of function in the FtsK/SpoIIIE ATPases of ESX secretion systems. J Mol Biol. 2015 Mar 13; 427(5):1119-32. Ramsdell TL, Huppert LA, Sysoeva TA, Fortune SM, Burton BM. PMID: 24979678; PMCID: PMC4277743.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    48. Dimer recognition and secretion by the ESX secretion system in Bacillus subtilis. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7653-8. Sysoeva TA, Zepeda-Rivera MA, Huppert LA, Burton BM. PMID: 24828531; PMCID: PMC4040557.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    49. The ESX system in Bacillus subtilis mediates protein secretion. PLoS One. 2014; 9(5):e96267. Huppert LA, Ramsdell TL, Chase MR, Sarracino DA, Fortune SM, Burton BM. PMID: 24798022; PMCID: PMC4010439.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
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