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Jean-Philippe Coppe, PhD

Title(s)Research Scientist, Laboratory Medicine
SchoolSchool of Medicine
Address2340 Sutter Street
San Francisco CA 94115
Phone415-514-1035
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. Aging Cell. 2019 12; 18(6):e13027. Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y. PMID: 31493351.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. JCI Insight. 2019 06 11; 5. Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van 't Veer LJ, Campisi J, Coppé JP. PMID: 31184599.
      View in: PubMed   Mentions: 6     Fields:    
    3. Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities. Nat Cell Biol. 2019 06; 21(6):778-790. Coppé JP, Mori M, Pan B, Yau C, Wolf DM, Ruiz-Saenz A, Brunen D, Prahallad A, Cornelissen-Steijger P, Kemper K, Posch C, Wang C, Dreyer CA, Krijgsman O, Lee PRE, Chen Z, Peeper DS, Moasser MM, Bernards R, van 't Veer LJ. PMID: 31160710.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance. Nat Commun. 2018 10 17; 9(1):4315. Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y. PMID: 30333494.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Cellular Senescence: The Sought or the Unwanted? Trends Mol Med. 2018 10; 24(10):871-885. Sun Y, Coppé JP, Lam EW. PMID: 30153969.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    6. Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors. Breast Cancer Res. 2017 Sep 11; 19(1):107. Bartelink IH, Prideaux B, Krings G, Wilmes L, Lee PRE, Bo P, Hann B, Coppé JP, Heditsian D, Swigart-Brown L, Jones EF, Magnitsky S, Keizer RJ, de Vries N, Rosing H, Pawlowska N, Thomas S, Dhawan M, Aggarwal R, Munster PN, Esserman LJ, Ruan W, Wu AHB, Yee D, Dartois V, Savic RM, Wolf DM, van 't Veer L. PMID: 28893315.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer. Cancer Res. 2016 04 01; 76(7):1733-45. Olow A, Chen Z, Niedner RH, Wolf DM, Yau C, Pankov A, Lee EP, Brown-Swigart L, van 't Veer LJ, Coppé JP. PMID: 26921330.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E2977-86. Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SJ, Boffelli D, Di Noia JM, Martin DI. PMID: 23882083.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    9. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol. 2013 May 13; 201(4):613-29. Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J. PMID: 23649808.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    10. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem. 2011 Oct 21; 286(42):36396-403. Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J. PMID: 21880712.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    11. Metallic nanocone array photonic substrate for high-uniformity surface deposition and optical detection of small molecules. Nanotechnology. 2011 Jun 17; 22(24):245710. Coppé JP, Xu Z, Chen Y, Liu GL. PMID: 21543836.
      View in: PubMed   Mentions: 1     Fields:    
    12. GROa regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation. 2011 Apr; 81(4):222-32. Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ. PMID: 21396766.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    13. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci. 2011 Jan 01; 124(Pt 1):68-81. Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J. PMID: 21118958.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    14. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010 Jun; 29(2):273-83. Davalos AR, Coppe JP, Campisi J, Desprez PY. PMID: 20390322.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimals
    15. The helix-loop-helix Id-1 inhibits PSA expression in prostate cancer cells. Int J Cancer. 2010 May 15; 126(10):2490-6. Zielinski AJ, Fong S, Allison J, Kawahara M, Coppe JP, Feiler H, Lee NM, Desprez PY. PMID: 19662653.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 2010 Jun; 9(3):398-409. Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. PMID: 20331441.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    17. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One. 2010 Feb 12; 5(2):e9188. Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour CM, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J. PMID: 20169192.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    18. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. Coppé JP, Desprez PY, Krtolica A, Campisi J. PMID: 20078217.
      View in: PubMed   Mentions: 763     Fields:    Translation:HumansCells
    19. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009 Aug; 11(8):973-9. Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. PMID: 19597488.
      View in: PubMed   Mentions: 582     Fields:    Translation:HumansCells
    20. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008 Dec 02; 6(12):2853-68. Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. PMID: 19053174.
      View in: PubMed   Mentions: 919     Fields:    Translation:HumansCellsCTClinical Trials
    21. A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res. 2008 Jul; 6(7):1085-98. Coppe JP, Boysen M, Sun CH, Wong BJ, Kang MK, Park NH, Desprez PY, Campisi J, Krtolica A. PMID: 18644973.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006 Dec; 10(6):515-27. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. PMID: 17157791.
      View in: PubMed   Mentions: 1305     Fields:    Translation:HumansCells
    23. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem. 2006 Oct 06; 281(40):29568-74. Coppé JP, Kauser K, Campisi J, Beauséjour CM. PMID: 16880208.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    24. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci. 2005 Feb 01; 118(Pt 3):485-96. Parrinello S, Coppe JP, Krtolica A, Campisi J. PMID: 15657080.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    25. Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression. Clin Cancer Res. 2004 Mar 15; 10(6):2044-51. Coppe JP, Itahana Y, Moore DH, Bennington JL, Desprez PY. PMID: 15041724.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    26. Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells. Cancer Res. 2003 Nov 01; 63(21):7098-105. Itahana Y, Singh J, Sumida T, Coppe JP, Parrinello S, Bennington JL, Desprez PY. PMID: 14612502.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    27. Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13543-8. Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM, Debs RJ, Desprez PY. PMID: 14578451.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    28. Id proteins in epithelial cells. Exp Cell Res. 2003 Apr 15; 285(1):131-45. Coppé JP, Smith AP, Desprez PY. PMID: 12681293.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    29. Helix-loop-helix proteins in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):225-39. Desprez PY, Sumida T, Coppé JP. PMID: 14635797.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
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